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                  <text>December 19, 1966

It” of
WInstitute
Hiami
Wm
W.

No

suoo Ammo].

‘

Street

St. ‘Muia, Missouri 63189

Dear Enron,

Iravemadthepmtoooloftmpmpoudthiwiminem

diphanylhydmtoin study with great interest. This is an
importmt stuiy am I think the asthmatic: of controls. ms

of patients wide: the basis
witwia and mm assigzwt
which may be
"

for a definitive smdy. I have fmr questions
useful in clarifying the protocol. These are chiefly in the
direction of cmifioatim but do not mdify the study at all.

‘maoritwiafow-agommazmmlitiesmmtcm.

SinestMEBGismxdergoinﬁolmge-withagemtm

www.mmmmmmmdafmwm
Emma
W
mwitwion,doesitmantmtpatientsmodonotravean
Ifoo,perhapo

populations equated for age as the single most importmt variable,
With regard to the
capacially fort):

mmwillboemlxmdfmntmnxﬂy?
atlmttwolengthymomdimsstmldbedonesotkatthis
criterion in the ample can be adequately definod.

Isthdmutimofthastudyadofinitemortobeclinically
define

it possible to
aixornimmonths?
either
four,
aniniumtmatmntpcriodof
Justuthoritwimﬂntapationtmmtbogivcnotherdmgs
for now than fivo day: an automatically mludod is a definite
radiation for
om,
maths thwalyokwldalnobemlmdfrmtmnudy.
omission is a definition of the
Tho single most
Sinoeymhwcaspocifiomimsoalo
witorin'foriwmrt.
for Wﬂnlogionl aspects, would it not be helpful to damn

detaminod by the youth cantor director? In

1033me

meatimtmmived

Wt

intrnpmtoooltMMtwintobauudfwthedcmeofomnge?
in

W,

These possibly should include

poyclmotor activity,

diammotiomlity.
We

altmtiom. in
opiaodic

and

�Dr. 11:11

-2-

December 19, 1965

Finally, the dose of diprmmylhydantoin is smoified as
this may be too low. Surely these adolescent subjects
are able to tolerate 300 mg and this may be a more effective dose.
Also, the thioridazine dosage is given as a range of 75 to 200 mg
madthisstxmldbemadecleamr. .Isthedosageaminimmaccozdhg
tohodyweight? Isthereamaxixmntobegiven?‘
200 mg and

'

'I'headditionaltrmght,vmich1amsmeymconsider~ed,is
that of sleep EEG's taken prior to treatnent and perhaps at the

end of three or six mnths. This may provide special information
regarding fourteen and six positive spikes.

I wenelosingan additional

carbon for-Dr. Turner,
may be helpful.

event that you believe these caments
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MFﬂcp

-

inthe

�</text>
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              <text>Correspondence to: Itil, Turan M.</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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