http://exhibits.library.stonybrook.edu/mfp/files/original/b566e18c2c276dfd0f3a17f46a6be344.pdf 5acc5c357c5bab0130e7461aafd44cea PDF Text Text D ii F S E g chember 14, 1966 Dr. F. R. Peterson Bristol Laboratories Syracuse, New York 13201 Dear Dr. Peterson: There has been a great deal of work on the effects of psycho— active drugs on the electroencephalogram, and this has included studies of the antidepressants. EEG patterns differ for each compound and for each class of compound. These observations, especially those which have been done quantitatively, have been useful in defining the clinical range and probable efficacy-9f new compounds in psychopharmacclogy. EEG studies should be .considered safe for human done in man as soon as the drug is experimentation. If a compound in the recommended dosage evokes no measurable index for psychotropic drug efficacy EEG effects, the therapeutic is probably very low. If the EEG changes are still unmeasurable at maximum dosage ranges, the compound will probably have little clinical merit. If a specific pattern is evoked in electroencephalograms, the therapeutic index can be defined with great accuracy. Optimal methods vary. 'The techniques evolved during the past decade started with visual descriptions, followed by analog frequency analysis and analog amplitude analysis, and most recently have been replaced by digital computer methods. The present sophisticated techniques make possible accurate delineations of the probable therapeutic range, if drug studies are dene accurately and early. . While these observations have not yet been considered by the present FDA as an essential part of a new drug application, the reports have been of great interest and considerable support to numerous pharnememfiical clinical directors, especially those who have had the opportunity to study quantitative data. �Dr. Peterson -2- November 11;, 1966 A.laboratory for the quantitative evaluation of EEG criteria being established at this Institution, following my experiences as Director of the Missouri Institute of Psychiatry from 1962 to 1966. It will be Operational in the late spring. Such quantitative EEG evaluations can be undertaken in St. Louis by my associate, Dr. Turan Itil, who now has the laboratory for clinical e1ectro~ encephalography at the Institute; and alSO by Dr. Carl PfeiffEr and Dr. Arthur Sugeman at the New Jersey Nam-Psychiatric Institute. is now If additional data regarding these interest, I Street would suggest you (212 369—7900) at visit the experiences would be of at 5 East 102nd College your convenience. _ Sincerely yours, Fink, M.D. Professor of Psychiatry Max mf: kp � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Peterson, F. R. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-020-8-495 Date A point or period of time associated with an event in the lifecycle of the resource 1966 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence