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                  <text>actobur 12, 1966
Ex. Rebert C. anhleh
Medical Liaison staff

Clinical Investigation Department
Smith. Kline and Prendh Laboratory
1500 spring Garden Street

.

Philadelphia, Pennsylvania 19101
Dear Bob.

I would like to bring you up-to~dnte in our
barbiturate ~ 830 study. The data collection ended
in June and during the past few nonths, sanples at
every 12 minutes were selected in relation to the
reaction tine experience. These samples were dhsdked‘
for nrtefact end the data of‘the various subjects was
put on a disk.
_

The

,

first

analyses were to determine Whether

there were any significant differences in any of
the EEG variables in the four groups prior to drug
administration at any of the treatment periods. 'The
datn'denonstrnted that the groups were equivalent
for each of the EEG variables for eedh of the tour
drug conditions. with the exception that three of
thirty~seven indices dhowed considerable variability
during the first study in these subjects. That is.
some of the subjects ethibited lesser amounts of
alpha activity and more beta activity in their tirlt
recording than in the subsequent three recordings.
Thin observation is not unique since many
observers have reported that patients any be very
anxious during the first session and perhaps this
single record should have been thrown out. However.
since ditterent treatments were used in the first
drug period on a random basis. we do not think thet‘

will significantly bias the overall
5:1.
"hi.

dhenge

�'Kr-(‘F‘

Hr. Zudhlcn

~2-

Octdbcr 12. 1966

Tart: £6: dirtnroncun ascrthiblo to drug ottacts

ondh tint period are naw in progresl and I hnva
bacn natured by my 8:. Louis Isaociatas that tho

at

data thould h. avatlahlo within eh: next tun wicks.
as I have this I w111.cwll.you.and will
arrangc for up to go over them together.
Thank you once again for your interelt.
Sincerely yours.

As soon

Max

Pink. H.D.

Professor of Paychiatry

�</text>
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              <text>Correspondence to: Zwahlen, Robert C.</text>
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              <text>1966 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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