http://exhibits.library.stonybrook.edu/mfp/files/original/7defb938ce2262c49752d69a21de6f6d.pdf 5a753824ca2576c05cbbf0c478051e0c PDF Text Text Spinal Fluid Findings Following Cerebral Angiography Joseph, M. Stein, M.D. and Max Fink, M.D. WITH increasing use of cerebral angiography, the problem arose as to Whether the procedure, of itself, produced changes in the cerebrospinal fluid. Forty— eight hours after angiography a spinal fluid examination in a patient suspected of a brain tumor revealed a cloudy fluid with 3,000 white blood cells per cu. mm. Prior to angiography the fluid had been clear, colorless and without any cells. As, no information concerning the relationship of pleocytosis to angiography was available, it was decided to study the changes in the spinal fluid by the usual clinical methods. Spinal fluids from 21 patients were examined prior to and following angiography. Lumbar punctures prior to angiography were done at various intervals, but all punctures following angiography were performed between 12 and 24 hours after the procedure. In each instance the spinal fluid was exam— ined for color, cell count and total protein content. All angiograms were percutaneous, using 35 per cent Diodrast as the contrast medium. Maximal Diodrast volume was 70 ml. at one procedure. While the majority of patients were subjected to unilateral carotid punctures, bi— lateral punctures were done in four, and combined bilateral carotid and ver— tebral punctures in one patient. Either intravenous Pentothal (14 cases) or local procaine (seven cases) anesthesia was used. RESULTS Of the 21 subjects, significant changes in the spinal fluid following angiography were seen in only two cases. In one, a patient with a cerebral an— giomatous malformation and multiple aneurysms, 5,000 red blood cells per cu. mm. were seen in a pink spinal fluid. In the second, a patient with a chromophobe adenoma of the pituitary gland, the protein content of the spinal fluid changed from 89 to 151 mg. per cent; also, seven lymphocytes per cu. mm. were recorded when previously there had been none. In all other subjects, changes in color, protein content and cell count were not significant. Three subjects showed transient hemiparesis following an— From the department of neurology and psychiatry, New York University College of Medicine and the neurologic service (third division) and psychiatric division, Bellevue Hospital, New York City. Reprinted from NEUROLOGY, Minneapolis, February, 1953, Vol. 3, No. 2 137 �NE UROLOGY 138 giography, and in none of these were there significant changes in the spinal fluid. Since Diodrast can cause changes in membrane permeability,1 and the spinal fluid reflects such changes, it could be postulated that a relationship between complications following angiography and changes in the spinal fluid might exist. Such changes were not demonstrated in the present cases. F urther investigations with more exacting techniques for protein determination and protein differentiation are indicated. CONCLUfiONS Neither a marked pleocytosis nor a marked increase in protein content of the spinal fluid are usual concomitants of Diodrast angiography. It may be concluded that when such spinal fluid changes are found they are unrelated to the procedure. REFERENCE 1. OLSSON, 0.: Cerebral angiography: Toler- ance for contrast media of diodrast type, J. Neurol., Neurosurg., 1949. 6c Psych, 12:312, � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Published Works Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Spinal fluid findings following cerebral angiography. Neurology. 1953 Feb; 3(2): 137-8. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-02-01-001-10-014 Date A point or period of time associated with an event in the lifecycle of the resource 1953 Creator An entity primarily responsible for making the resource Stein, Joseph M.; <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Published Works -- Articles and Reviews Relation A related resource The Max Fink Collection Description An account of the resource Reprinted from NEUROLOGY, Minneapolis, February, 1953, Vol.3, No.2 Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Published