http://exhibits.library.stonybrook.edu/mfp/files/original/c2fff7f75fe1669637cb8260f710ede1.pdf 35df71ff44429c020fe64621ea928399 PDF Text Text ,\_j January 21, 1966 Alba-t A. Kurlend, Wt M. D. Director of Research of Mental Hygiene State ibepital Spring Grove Baltimore. Miami DearAl: Myouvewmhfcrmkingmmmem‘ipt of motel}; Ill Patiwts" "Oombimd Drug Treatment aveilsbletous. Wehvemeditwithagveatdeal of intereet, and despite your cannents at it length and statistical interjections, we found these interesting and valuable. As with our mm study, the princioel mestion mich is in the forefront is the influence of dosage on these commutims. In this study, the Wine-MW scores, differemes also combination showed” in from the chlorymeine— many Wim- placebo oombinetim and ctdordiasepoxide. The problem with seeking levels of significance from this data is that the best dosage combinetion my not have been achieved, and mg the variability the patients is sufficiently meet so that even in powletions of forty subjects, the differ-ewes do not achieve the statistical differences remixed However, the fact that ine-imipmmine arms changes in some 'pswmpBWlogioel symptoms while the mimtion of cflommzine and cflomiaaepcmide is often mtably poorer, provides belnvicml clues which are mistant with the eleommphio effects noted for moh contimtime. I m (2121sz the observation that sewed wipe-amino better in those with high depression scores. high retardation scores, and low agitation of west interest sime this parallels the moontmlled obsmatime mien were carried mt at Hillside I'bfipime �Answer obsmetion which seem is the differences Went to me sales and ferrules. Them have been many suggestions that female patients are more semitive to mmiszims and wibit pukimonism bah-ween earlierendetlmerdoeeges. Iknmefewstudies mmmmflwdosegewes muslledeooozdingto body weight. Also, in e numerof mlyses of the Hillside Hospitaldate,fim££6dw\gesinduoedbyohloxpmzim, when the clinical effects have been shown different for by imi‘prmim were different for males and females. Quack Hell, with Dean Clyde. mdertodc the analysis md mm sth that higher of the Hillside Hospital 1959—1952 data and the W1: of bets activity pmdmed in resales ' was finanthetinneleson‘memdmgdosage. Withthisin mind. the diffenemee might physiologioel factors, even ' stillbe related to neuro— if Megs were omtmlled. I also found of interest you" observation tint chlorpmemim and placebo was sueoessful in the alleviatim of retardation . This also is consistent ‘dflammmobservartions mdlbeliewthis is mother Wasteinthismpon. ‘ Inyourmvisimoffisisdmft.peflmpsflxefocus owld be plead on the clinical obsemtiorm , simly describing the unmade used and omitting the extremive dismssion of mfiwdolo‘gy and uflmdolegioel problem . mass are Wmm,buttheusmlmderemintemtedinthe clinioalduteam. Ithiflcflmolinicel detais W1: very clinical data presentation should the in wbliehed I’m ives or the Austrian Journal of 3: We and surely a have begm the analysis of a group of schizophrenic patients who have been pleoed serially for eight week periods on placebo. mlordiazepoxide slam (1 tug/kg), fixioridszim alone (5 tag/kg) and the ombimtion using half strength of each. Dosages were fixed. and the evaluations were done during the second four week period. The patients were long-term emiaophrenio subjects and all male. A copy of the present. revised date malysis sheet is enolosed, madthie willgivemepieturemtwermheve. meoxide Itis of interest to us that alone was not sigmifioenfly different than phoebe. But the smell mm edded to a mu dose'of thioridazim was sufficient to pmdmesignifiemtdmges inallthemtingsystem. This, we believe, argues for an mutation of the thioridezire effects by chlozwdiezepoxide . As you can guess, we are now involved in the further analysis of the individual items, and in fine EEG relationships �mummy mflwksforflwoppomdtytomdm IdoMpeitwillbepublislwdsom. m. but mm. fly Simmly yours, Max ijmh Pink. M.D. Professor of Psychiatry � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Kurland, Albert A. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-020-1-065 Date A point or period of time associated with an event in the lifecycle of the resource 1966 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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