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                  <text>'

Dr. McKeen

January in, 1966

Cattell, Editor

on Jour‘l of New Dmgs
1300 York Mamie
York, New York 10-021

New

Batten;

Dear- Dr.

Pleas accept

December

a. sooner.

my

apologies for not answering your letter of
the questions which you raised were

However,

verygemmdmyassociatesmdlhavestmggledwiththem

duringthepastfewweeks. Onetleuttwoomsimslhave sat
letters which attempted to mower the questions
which you raised and to justify the points of View represented in
incomplete and so we have redrafted
our diameion. These
the report are! two copies are enclosed for your cmsideratim.
dam and dictated

mo

have added the description of the changes in our patients
the patients were given
the initial observation period
eplacebo. Inlargepart,ﬂaechsngesmreﬁaoeethatareordinarily
seen on drug withdrawal in psychotic subjects with an increase in

m

We

chaﬁng

psychopathologioal

9mm.

It is true that relatively

results

cats-not

dosage

levels.

few

patients were studied

seem statistical simifiemce.

and

the

Nevertheless .
considering the passer: status of trifluperidol as a therapeutic
, we believed that our observations did contribute some
additional infmtim, specifically with regard to the higher

Hostafwinﬂmsthesbemfmsedmthequestimofﬁae

lessening of nemlogical effects as dosage is increased. The EEG
data provided supwrt for the animation that trifluperidol in
higher dosages has effects similar to mticholinergic oompmmds.
It is this suggestion which we are elaborating in the discussion.
While

was

this

:1th

relate to the lessening of neurological effects,
after treatment
little to the delayed

may

contribute
disoontimed.

we can

Thenk you once again for your questions and your interested
omsideretim of this study.

Sincerely yours ,
Max

Fink, Nd).

Professor of Psychiatry

Pﬁ‘mp

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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