http://exhibits.library.stonybrook.edu/mfp/files/original/f75871c913379081e668132f8e2d0b00.pdf f6bd4d35838a98cecb5d41034fb91993 PDF Text Text July 28 , 1965 John A. Stem, Ph.D. Departmnt of Psydliatry Malcolm Bliss Mental Health Center luzo Gmttan St. Louis, Missom'i 631014 . Dear John: SKI? study. on our ambarbital « for your my momentstake this opportunity to reply You am quite correct, and I will sons for the end of our to some of tho questions new; and reserve Thanks present study . effects is no literature review of mbarbital and chronic administratim is problem, for the EEG data on some my bibliography (196%) and detailed and quite good (e.g., see analysis literature is sparse, zero cmss 12—13 Bmisr's (1952)) . The availability of the tecmisnebyfor the however, and despite this I know of no good analysis of My drug effect (l) A years, mthod. placebo with drug effects "my were the analyses comparingand in our critique suggest also, so batten” .7" We are puzzledsapling problems and the small, our lack of control of sleep, are very 104 . Of course. our dosages naimogemous , sample focus of the present study. Daspitenolow the also, and this is we drug effects. This can dosage, I believe of 100 mg armbarbital IV in problem to demonstrate the effectdiscriminate the same dose minutes. It is a problem to 2:31 waste 1y. (2) N artsfact; or, it 8 20, d.f. = 18. Our error. regaining variables (3) The shifts in the patterns of the Apparently, analysis is a problem. with some condiin discriminant fmctim change show greater degrees ofand diffcmnt momma be a statistical sample tions. This may reflect our small Further differences. drug effect studies may must be done mpmsent to answer this criticism. �(u) Incidentally, the direction of drug chamgcs are indicated in Appendices 2 and 3 by the signs . For example, in Appendix II, baseline cross average at 60‘ was much higher (increased beta activity) for 300 mg than 50 or 100 mg. 02.67“, 1.3., 4 is greater than 2). Similarly, 50 mg (2) shoved a slower Wane cross them placebo (al.96) but not significantly so. (5) Your commnt about the Drohocki integrator and is technically correct, but in operation the curves are different. Drohocki uses a wide band"frequency analyzer" output W filter denying that any information resides in Our data suggests that frequency is a: important aspect of EEG signals, and while power spectral frequency analysers can be tuned to narrow bands, and thereby show shifts in frequencies - these data are oonfomded by amplitude chmgss. ms merit any - of period malysis is that mflacts frequency information independent of amplitude . wicfth shifts in fmquancy. ~— (6) A hope if it or a prediction ~ note the word "potentially." The reminder of your consents are equally cogent, and I will incorporate them in the naxt draft. I am grateful for your time and consideration in mviwing this progress report. We are replicating the study, correcting as many of the flaws in the first study as we cm. George has mantimsd your consideration of another laboratory in Cincinnati. I hope the Opportmity will met your expectations . that I have been puzzled, and somwhat chagrinsd that the Opportunities in this center did not stimulate your interest . Our political problem were gmat, and perhaps may still be overwhelming - but I am confident that George would You must know be most enthusiastic you wish. to have. you Have a pleasant sunmer, and our progress report. join Missouri. many thanks University, if for your review of Sincsm 1y yours , Fink, M.D. Professor of Psychiatry Max Hfzkp P.S. While this report is not mady for publication, I am submitting as an abstract to Neil for the next SPR meeting. Perhaps the it Program Colmnittea would like to include such a report of an applicatim as a follm~up of last year's methodology papers . � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Stern, John A. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-019-5-446 Date A point or period of time associated with an event in the lifecycle of the resource 1965 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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