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                  <text>'0.” "a:

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ﬁr. Bobart Goldman
V100 President, Research
Ryaaa nabaraﬁoriaa, Inc.

54024 Vbrnon‘ﬂauluvnrd
Island city, Kaw‘Ibrk 11106

Long

Dear Er. calaman:
W; are imaged

interestad in tha applieation at
datarminution of drug erraata.
a first stag: study fer Smith
just
Kline &amp; Frauen Laheratories, which dnmonstratad
differences botwoen different deans» farms of amobarbital.
W» nra net in tbs proacsn at repliaatingthia study
tor

EEG technique:
tbs
Nb havu
gouglotod

.

I helluva 1t annula ho possible to introdnae papararino
fbr a numbar or trial; early in our program.
I ﬁbula reaanuond that you supply as with pspnverino
er'othnverino in a auitablo 603339. We would adminﬁhor
uh: aemPGund and abaerva whether-we antaxn any EEG otrbats
tram a tingle Geno. Filling that, tn uwuld parhnpu repeat
baa deaago at anamhalt hcur er nae hear interValq until
us absarva what wo reel 13 an elsatrographic effect. If
this scan, was .mla then suggest a trial in
uriva“ﬁshnet:
an eight subjeatn in whiah a plaaabo and papavarino
are administered in aoma alternate aoquonee.
To do no. I woula raquira a supply or pupavarino
in capsules watched with a anyply nf'plaeebo. I would

and

.

estimate that an initial anpply at thirty units each
us he dateminﬁ 11' papavarine has an EEG
my} pamit
A
«primitive
supply £69 uh: first study mania
street.
wn finé suitable;
whiah
dnpond on the dasaga
the first
I helluva that theta tie steps would waanswer
data:—
could
your prOpOBOd thug part prawn. If
of
mine papaverina‘a action in a darinita 4939 by EEG msﬁhoda,
than it should be passiblo t0 earry out soeand and third
utap nimnltanaoua studios in a group of valuntears the
randomly reaaive either a nonntimed 6099, or triple thﬁ
nonutimad doaa or the timed daae, It dons properly,
aiseriminant function analyaip will datermine uh»
airfarancou or similarity botuoan the three runs.

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we.

Ev. Goldman

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_

June 25, 1966

a supply or
an: step can vauld reqplrehave
carry
aortain»
we
ulruady
Sine:
from
undieatioa
yen.
1!
would
be
3K?
your
helpful
vary
anpsule: tram
it
1dantienl
capsule.
tha
campauud Gould be put up in
roanen, I am sending yum a samplo or an: 3%?
Eb:
$0

m3.ibis

.

I would be
to the cast of such initialtrial,
Our
volunteer:
pleased to do it on tbs aoat basis.
arm paid.at ch» rate of $3500 an hanr. Our laboratory
toahnieiuna and incidental asst: avarage $5.00 an hour*
At tho praaant time for uni; step of tha inventigntion
we vuula make no charges far our aompuhar ar.other
ganarnl laboratary casts. Ir tho initial trials raqpiru
fbur
five subjects. tun trials par subﬁaatg avuraging
thay
hawavnr.
$400.00:
haurt. tho cost may approximate
Eh»
mars
it raunlti
any h. lens 1! '3 tall ané slightly
banana ales» qn1¢k1y*ana yo decida-ta dn'many samples.
tbs initial ﬁriala araﬁnatiufnctary, we will
It
vaguent &amp; aonsultation tag of gvso.ao.
these pralinanary data urn mutually satisfactory,
If
budgat¢d to pravida support
the datmnitivo teudy will beand
ear nﬁuraphyaiology
opanationa
tar our computer
raga»
direct costs and aonaultation
laboratory dbovo thoknow
1a
a
zabcratory
ﬁhat this
I think yam thauld
the 931%.
unit and'that in with
university Iuppartad raaaarah
out
been
aurried
have
A3

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-

such aonsulhutiena which
with sum: of
pharmaceutioal aanacrnc hnva providad.un
man
we
new
nae in tho
aha apacialisod aqpipmant ﬂhioh
otudiao suggested in this letter.
assumption as em 833m}:
I am. mama mm your
pram" vary interesting and I am leaking 20mm to
'

this study.l
I trust chit intbrmatioﬁ is sufficient. and lack
forward to napkins uith you.
Sinenraly yaurs,

“,—

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Pink, 11.1).
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Protbaaar of Paynhiahry

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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