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                  <text>June

2s,

1965

Jr.
Statistics Section

Dr. Spencer-M. Pros,

Section Head,

anith Kline

8

French Laboratories

1500 Spring Garden

St.

mindelphia, Pennsylvania 19101
Dear Dr. Pme:

Shapiro, Tumn Itil and I wish to thank you for your
thoughtful and painstaking review of our program report. We
have reviewed each of your commts and I should like to report
our cmclusions.
Don

,

The lack of discrinﬂnation of the 300 mg sustained release
four
hours resulted from Our poor control of behavioral omat
mitants, including variability in sleep. I think this is
clear in our critique. It is an important questim to us and
that we should replicate this study with the
it is our feeling
described
mdifioatims
in our second program report. While
we thought it would be important to take recordings during the

hour, your comments make it clear that this would not be
necessary but rather that we extend the recording heymd four
hams, perhaps to six or seven; and, indeed, perhaps to record
the subjects at eighteen and tmnty~four hours for additional

first

samples.

‘

Regarding the

-

statistical

mots,

we

have accepted two

of your suggestions, and are now plotting the "F?’ values for
each discriminant solution that used all the variables. We
are also planning to run some of the additMal single variable

(t-tests) that were omitted.
Thank you for telling us about the errors in identification

analyses

of tables

four and five.

v

With mgaxd to the data that you wanted, I have asked
Miss Hickman to copy all the data sheets and these will be
sent to you as soon as they are available. I will be glad

send you the cards

to
that are already punched, but tress reflect

�Dr. Spencer M. Free,

only a

Jr.

mall part of the data.

on cards and

to you.

if

Jtme

~2-

you wish them,

She
we

will indicate

what

2M, 1965

is

already

will duplicate and sutmit them

'
_

that your review engendered,
with
some of our statistical techniques and
was a dissatisfactim
our desire to replicate this study. As you will note fun the
letter which I an sending to Mr. thlen, I am requesting additional
supplies and I trust that this second study will clear up sons of
the questions presented both by ourselves and by you and your
Perhaps the most importmt feeling

associates.

Tram you owe again for your interest.
Sincerely yours ,
Fink, 11.1);
Professor of Psychiatry

Max

Hfzkp

co:

Mr. Robert

thlen

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