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                  <text>February 15. 1965

Mr. Robert G. awshlen
Smith. Kline 5 French Laboratories
1500 Spring Garden Street
Philodelphis, Pennsylvanie 19101

Dost Bob:

It was s plessure having you visit us on Thursday. The
second series of analyses are new in ptngress. end I trust that
will have the study completed within the next foot weeks.

I

I vould be gtsteful if your laboratories can help us with e
specific problem. Eerly last year. the study group under or.
Itil's direction ensuined the EEG and clinical effects of the comp
bioetion of ohlorproneaine and bitten. They were impressed with

the clinical effect and e number of triels were undertaken with
other enti~cholinergio drugs. ineofsr as bitten is an experimental
egont. Similar results were eohieved with stropine. However, the
dosage of etropine necessary to induce clinical effects was in the
tense of 10 to 20 age/day. To accomplish this doesge by the psrentersl
route toquired large amounts of fluid to be injected. Insofar so
we would like to administer this doolge dsily for e nnnber of weeks,
we ere desirous of obtaining concentrated atropine in
injectshle

{one

‘

For this application, we would like to have atropine sulphate
in e ooncentretion of three to five na/cc. This should
be made
available in either ampules or vials end we would need a quantity
equsl to 5.000 units (1,000 unite st 5 malco) for the initial study.

grateful if the phernsoologiets st SKI could sdvise
to whether such e coneentrstion can be produced either at your
laboratories. or by e commercial concern whom we any content dixeotly.
If this concentration is not practical. can you advise
us so to e

I

no es

would be

concentration which could be developed?
Thenk you very much

for your help.
sincerely yours,

m Pink, 3.1).

Hfzjn

Professor of Psychiatry

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              <text>Correspondence to: Zwahlen, Robert C.</text>
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              <text>mfp-05-00-019-1-086</text>
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              <text>1965 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>The Max Fink Collection</text>
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            <elementText elementTextId="15282">
              <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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