http://exhibits.library.stonybrook.edu/mfp/files/original/c23814dfd6b6cc6693b7971277f39383.pdf 6eaca1eec819dcf260ca7a7c57ebb5fa PDF Text Text October 6, 196% Brazier Brain Research Institute University of California Medical Center Los Angeles, 214, California Dr. Mary A. B. Dear Mollie: I was disappointed in Santa Fe that you had not come. There were a number of questions that I had to discuss with you. The matings were excellent and Don Walter read your paper very Your pictures, and Grey Walter's description stimulated in the recollection that the changes that you see in the scalp frequency pattern are very close to those seen with the administration of imipramine. I am taking the liberty of en— well. me closing some photographs _' of frequency spectra. In studies with Imipranfine there are two additional observations. Borenstein has déscribeé dysrhytmic patterns in scalp electrodes and there have been occasional reports of spikes in patients receiving imipramine. Also adolescent sub= jects who are psychiatrically disturbed have become excited and administered indpmne. While you have presented the analysis of the frequency spectra when the depth electrodes showed spikes, was an evaluation of the frequency spectra carried out to determine if Spikes were indeed present when the scalp electrodes showed the oranges in frequency spectra? sham acute episodic behavior disorder when , In additim to the figures which are sufficiently ex— planatory, I am enclosing a copy of the report in which I give the statistical data on chronic imipramine admnistretion and this shows that there was a decrease in the amplitude of alpha activity, and an increase in delta and beta (22—33 cps). While this table does not show that the delta and alpha changes are significant, they become so in the final report which is now in press. �-2Dr. Mary A. B. Brazier October 6,'196u I am also taking the liberty of enclosing a copy of the report that I presented in Bimfingham on August 3lst. It was while writing this paper that it became clear to me that an important addition to the data available to me would be obtained from studies in patients with depth electrodes. When I visited the B.R.I. in May, I was escorted by Dr. R. Walter who showed me a patient in whom EEG's were recorded fmn both the scalp and the depth during varieties of psychological task performances. You have indicated that infatuation obtained concurrently from the depth and the scalp would be more favorable than fmn the scalp alone and this latest report supports this. Would it be possible to visit with you and spend some time ohserving your study prog'emsz I am free to set my own time sch-— edules and should like an opportunity to explore the possibility of carrying out some systematic observation of drug administration in a subject with both depth and scalp electrodes. I do not 1mm much of the politics of such. an mangement but believe I can utilize the resources of try Institute to support all necessary and proper expenses . It is possible for me to justify a trip to California to attmd the Fall Joint Computer Conference October 27-29 and should like to visit with you, if only shortly, either just before or just after those dates. I shall send this off today and will call you in the early of next week in the hope that some arrangements can be made.part Sincerely yours, PM, m Director mf/ is e nclosures MOD. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Brazier, Mary A.B. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-6-667 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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