http://exhibits.library.stonybrook.edu/mfp/files/original/19bffedeb4ed5bc2098a7b205548684f.pdf 2fd7ee5d82ca21ff7b0ca9e430024ef3 PDF Text Text October 1, 1964 I. John Nurnberger Chairman, Committee on Program Society of Biological Psychiatry 2010 Wilshire Boulevard Los Angeles, California 90057 Dear John: My assistants recent letter. and I have discussed the problems presented in your Two problems come to mind as central topical areas. psychiatric research is being done with animals and while there is occasionally reference made to the species involved many 'young dogs" or reports are presented in which the comment "rabbits", etc. These nonwspecific terms hide the great variabil— ity within the s ecies and among species. We have been preoccupied for years°§n the species differences among humans and espec~ ially the sub~classification of "sick humans". In psychopharmacology we pay a great deal of lip service to the needs of toxicity studies and trials cf new compounds in animals before administration much is' in man and we know very little about how to translate the observations in animals to men. For these reasons I would suggest one central area as the interrelationships in observations in animals and in man in psychiatric research. During the past decade there has been a great deal of emphasis en the neurohumors adrenalin, noradrenalin and serotonin. Biochempharmacologists and psychiatrists seem preoccupied in tracking this model. When we look at the pharmacology of the most ac— tive psychotropic drugs, examine the most potent hallucinogens, try to understand the convulsive therapy process, we always come back to acetyleholine and cholinergic mechanisms. I can not understand why these have been so grossly ignored ~ unless it is that the methods of assay are difficult or that the psychiatric leaders in Washington who seem to set our styles, have followed the lead of the cardiac psychologists for whom adrenergic mechanisms are most important. With this background, I would like to recommend a second ists, down topical area, that of cholinergic mechanisms in mental illness. general ideas of the first topical area which you if the subject interests you, I should like to make a special recommendation in regard to the While I have some I will gladly share with �' —2- John I. October 1, 1964 Nurnberger, M.D. second field. For many years I have been interested in the problem of antagonists to hallucinogens and during the present year have been most fortunate in having two associates join my staff whose interest in this area is also great. I should like to suggest, therefore, that you consider a symposium in the general problem of "Antagonists to Hallucinogens as a theoretical model for the mode of action of drugs". I would like to recommend that participants include Dr. Gershon and Itil of this staff, Abood (Chicago), Dille (Washington), Schueller (New Orleans), Zola Horo— witz (New Jersey), H. Wills (Baltimore), Hock (New York) and Stevenson (Richmond). ' Knowing our president, I believe that either subject would 'be of great interest to him. I agree that we should be pre~ pared to have a program focussed on psychopharmacology and I look forward to discussing this further with you. I trust those comments are helpful and I look forward to having you visit St. Louis soon. my assistant, Dr. Sletten who has been in touch with you, should work out a date which is mutu- ally helpful. Sincerely yours, Fink. Director Max mf/ls M.D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Nurnberger, John I. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-6-660 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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