http://exhibits.library.stonybrook.edu/mfp/files/original/dbeae5c28c2028b91dfcecb22649dbbc.pdf f872a69e5d5b738ceff9b34f83f6a7f7 PDF Text Text September 21, 1964 Irene E. Waskow, Ph.D. Research Psychologist Psychopharmacology Service Center National Institute of mental Health Bethesda, Maryland 20014 Dear Dr. Waskow: Thank you for your recent letter and I am sorry that I have not had an opportunity to answer you sooner, but I returned from my helidays within the last two weeks. As you know, the subject of language measures as an index of behavioral change with psychotropic drugs has interested me for a number of years. This summer, prompted in part by some of the discussions held by the Clinical Committee with Jonathan Cole, I asked a medical stu~ dent and a member of my staff to repeat the T.T.R. measures with LSD. They were able to complete the examination of seven schizo~ phrenic patients, each of whom have received an oral administration of 60«7O gamma LSD in our EEG laboratory. Speech samples were taken prior to drug administration and hourly up to four hours. The tapes were transcribed in two sections, an unstructured and a structured portion. In the structured portion, the student had been encouraged to administer the proverbs test, selected from the WAIS. A sufficient sample of record was transcribed to provide a minimum of 16 twenty—five word samples for T.T.R. and time measure— ments. The technique of T.T.R. followed the description by Jaffe. far, we have analysed four measures—the T.T.R. and the time for a twenty~five word sample and standard deviation average for each of these measures. So Using non-parametric statistics and visual review of the data, it appears that the effect of LSD in these subjects was to increase the mean T.T.R. (increase variability) and increase the duration of twenty-five word speech samples. The other two meas— ures were not significantly different from the resting level. These observations were consistent in the unstructured portion of the interview only. for the amount of variability and change in the structured portion was very small. �-2- ' September 21, 1954 I have encouraged my associates to examine a few more records and carry out a few more such interviews so that we might determine if these observations are consistent in another group of ten subjects. Also, we are now examining our data for the correlation between the language measures and the EEG changes. I an optimistic that if the measures of vocal dimension are reliable, that-they should change with drug intake. At the time that we began our interest in speech measures, Joe Jaffe explored the possibility of using pitch and volume as measures of affect change. Because of the technical problems or perhaps the drugs did not effect this dimension, we were unable to observe consistent changes in our study groups. It was partly because of the failure in the measurement of these dimensions that we sought for more objective scores and Dr. Jaffe extended his interest in the T.T.R. and such other formal measures of speech. With regard to your own study, I plan to be in Washington at the forthcoming meeting of the Committee Clinical on October 15—16, 1964 and again for the A.C.N.P. 1964. on October 23~24, I would be pleased to have an opportunity to meet with you and Martin Katz to discuss your work and our observation as well. Thank you very much to meeting with you. for your letter _ and I am _ Sincerely yours, Fink, Director Max mf/ls M.D. looking forward � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Waskow, Irene E. 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