http://exhibits.library.stonybrook.edu/mfp/files/original/7fabb684b5cf47d2c10aeb59f5ba0941.pdf 0420620efc0522c16122103d4ee55f2a PDF Text Text ‘September 17. 1965 a Tureu clo ltil. K. 613 H.D. Topkepi Satay Istanbul. Turkey Deer futon: for your letter from Stuttgert end for the slides. I returned to St. Louie, I found the program running very well. Everyone seemed quite content and I wee moot pleased with the progress that occurred during the month of Ansuet in the laboratories and nice in the petient studies. As for specific questions and problems, I will ehere some of these Thank you very much When with you and none of the decieioue which I have made. butepereeine study is good. and I reviewed with Ali his proeentetiou to the E.GiD.E.U. group. Instead of making up slides, he will make up a number of tables and will have these winner graphed for presentation to the group. The etudiee of pentothel activation are running well. 10 day interwele, six patients receiving and triflluperidol, I eeked Ali to give Mrs. Dierker three names of petiente receiving butepereriue and three patients who V111 receive thiorideeine. These twelve petiente should receive peutothel EEG: and computer analysis about every 10 days until each one hes had six to eight measurements. These will be taken during the drug—free period and then while on a drug. The computer , we will be following at . study is in progress. I reviewed the one record using the computer in which you have pentothel eetiwetion. To my eye, this did not help the discriminetiou. Two of the volunteers have been done, but one in Mrs. McDonald. who he: been pregnant end I think this series will not be «petal for us. Charlie is able to do two recordings e week. The SKI I reviewed your protocol of EEG computer study of different pheno— thielinee. Richardson could not start. end Ali suggested Tucker instead. The protocol is eetieieetory except that I would like to add on examination with trifluperidol end one with librium to bring the group to six. I am rewriting the protocol and will eend you e copy es soon as it is ready. Will librium et.l mglkg end trifluperidol at 0:2 ms/kg be e eetiefaotory dosage schedule? �Turan sept. M.D. Itil, 17. 1964 Page Tun In reviewing the LSD work with Andy, it became obvious that he has had an extensive experience. The clinical changes are re* corded well and I thought it was important to have him start some EEG analyses to determine the EEG criteria for threshold and for tolerance. we began this yesterday and hopefully, dur» ina the next two weeks, we will have some preliminary work in this area. Would you like to suggest how he is to determine the threshold affect on £36? I met with Mike Holden and reviewed the lobotomy and combined drug therapy projects. The combined drug therapy project is quite good, and-he has most of the patients for this group. The initial studies are in progress. The lobotomy study was unclear and we discussed this at some length. I suggested that the same problem would be faced by him as Andy faces. mainly the determina- tion of the differences in LSD. Ditran sensitivity for the will discuss this further. lohotomy and the non~lobotomy groups. we Magrinat began this week with Ali, and in principal, I accepted your recommendation that he participate in the study of epileptic disorders. The Oapolat protocol has some questions in it which can wait until your return. In the meantime, he is to get to know Ali's patients and will help him so that he can spend some more time in the laboratory. 1 reviewed some of the tapes made by Mrs. Wright and find that the .Offner is set with time consonants which lose the fast frequencies. Gene and Mrs. Dierker say that this has been done with your approval. Is there some reason why you wish the Officer set so that fast frequencies are lost? I would like to change the time con~ stants so that some of the fast frequencies will appear in the 0!£ner_rscords as well, but will not do so until I hear from you. with Harry and Sam. The Ditran study has progressed very well and they have an excellent clinical paper. Don has done a good job on the statistics. We agreed that they would prepare two reports, one of the clinical material in which the EEG would appear simply as a summary; and a second report in which the Ditran and lhorasine combination would he discussed at .1 had some wonderful meetings length. A third reports. on the EEG and behavioral relationships will await your return. In large measure. this is because we will have to undertake a detailed quantitative analysis of the Ditran records and I know no good way of doing this except by a visual analysis using your quantitative schema. While Harry will already have gone to England, I believe we should be able to write that report this Fall. I would like to send in an abstract to the American Psychiatric Association similar to the one you read at C.I.fi.P. Since it has to be in befora_0ctoher l, I shall assume that I have your concurrence in sending in an abstract of this nature. �Torah Sept. M.D. Itil, 1966 17. PageIThrea Jim has oarriad out some of the biochemical studies in spinal fluid and I have a summary of your observations on my desk. I hope to so over these with him as soon as I havo a chance. In the meantime. he has come to on with an inquiry as to whether he can assuoo responsibility_for the biochemistry laboratory; and whether we can-support or are interested in s biochemical program about the catachol amines.' I told him that this was difficult since we had neither the funds nor the stature in the research world to study this type of neurohumor. but recommended strongly that ho participate in our studies of cholinargic moth» aaians. He has demorrod. stating that his participation in such a program would be of secondary interest to him. After all, such s program would be largely ours and not his, and he has to make his mark in the world. I accepted his comments but indicated that it was not proper for us to assign the responsibility for the biochemistry laboratory to him since we were anxious to have s bio— chemist.primarily of s collaborating scientist. He has agreed, however. that the spinal fluid studies which you and be are under~ taking should be continued, and more important, that he would be pleased to carry out additional spinal fluid studies in patients receiving psychotropic drugs. with this in mind. and to broaden the coobined drug study program. I wonder if you would agree to the following associated study for Mike Holden? If we wore to collect the spinal fluid of patients on the combined drug study during their free period and again at various times when they receive one or two drugs, and measured the spinal iloid for cells. protein. the qualitative distribution of proteins. transsminese, cholinesterase, and any additional enzymes that we may be able to mossure in our laboratory - this would he a good supporting study for determining if spinal fluid changes markedly during drug administration. What do you think? - I vacation. Please give regards to our many friends in Istanbul. Ali sends his regards. and the whole staff misses you. hope you, Ellen and Kurt have a wonderful my Sincerely yours, Mex Fink, Director HP/Jb M. D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. 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Title A name given to the resource Correspondence to: Itil, Turan Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-6-623 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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