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                  <text>September 10, 1964

Donald F. Klein, M.D.

Hillside Hospital

P. 0.

Box 38

Glen Oaks, New York
Dear Don:
copy of a letter from Jonathan Cole. regarding the
depression paper. Thank you very much for e copy of your anxiety
syndrome report.

Enclosed

is a

I have proceeded following the recommendations of the editors end
especially Jonathan’s comments at the and. and an correcting the
manuscript. The number of changes are nininal. end the only question is the method of handling the comment regarding page 14. first
paragraph. Since this is primarily a clinical paper. it seems more
appropriate to delete the allusion to the heuristic model than it
is to expand the description. I think it were best to permit you
to expand on this in another report.
While in England, I visited Dr. Martin Roth and hsd an interesting
opportunity to allude to our experiences with inipranine end veri~

ous depressive cases. He has a young psychologist working with him
by the name of Clair Nelson Guerney, who has done a number of factor
analytic studies of the date collected in a large number of depressive cases. She noted two factors that seemed to separate her suh~
groups. The groups included a neurotic-depressive group. a phobic~
depressive group, a psychotic—depressive group and a manic-depres—
sive, depressed. She observed that one factor separated the psychotic—depressed end manic-depressed, depressed from the other two
groups. But she was concerned about a very strong factor that
separated the phobic~depressed and psychotic—depressed from the
neurotic-depression and manic-depressed, depressed. I suggested
that perhaps this factor was separating a group highly responsive
to iniprsnine from those who were less so, and suggested that she
refer to your work and your report on the anxiety syndromes. I

think their findings are of considerable interest.

Sincerely yours.
Fink, H.D.
Director

Max

Mlljb
Enc.

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