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                  <text>August 17, 1966

Sam

P. Wise, M.D.

Springfield State Hospital

Sykesville,‘Mery1end
Dear Dr. Wise:
Your

I

letter of July

27 hes been forwarded to me, and while

of no study that directly competes perpheneeine and
ohlorpronesine in their EEG effects, there are some studies
thet ere releted.end will give you a basis for study. These
include the studies by Bente 2; g;., Itil, Borenstein, and
Delay. The references are ineluded in the new bibliography,
Supplement g§_of the EEG Journal which will appear this
month; end in the volume by Dr. Itil. in press, which is
being published by Ahmet Sait Metbsssi, Istanbul, Turkey.
In generel, the Dtohoski method gives one aspect of electro—
physiologie change. minimizing frequency and power. If you
plan to compare these two compounds, I would encourage you
to review methods the: will give differences in these measures
as well an amplitude.
know

.

.

I an on vacation now and plan to return about September 10.
I will be able to answer your question in more detail then,
end will be pleased to send you a more detailed set of references when I am at my desk.
My

best regards to

Russ Monroe.'

Sincerely yours,
Fink,
Director

Hex

MF/jb

M.

D.

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