http://exhibits.library.stonybrook.edu/mfp/files/original/fed8158856c8c713e8b7faa3e27990e4.pdf 4d2fbd6bd7d3b32a45a8e274d0ca429c PDF Text Text May 9, 1966 Dr. John rarquhar saith Kline a trench Laboratories 1500 Spring Garden Stract Philadelphia, Pennsylvania Dear John: I have just returned from California, and ahould like to answer your inquiry ea to the possibility of using changes in the electrc~ encephalcgraa as an index of the effects of barbiturates. The history of the measurement of changes in brain function with barbiturates is a long one and it is quite clear that cost barbitu~ rates enhance the amount cf feat wave activity aypearing in the electroencephalcgran. The time of the appearance of this activity depends very much on the type of pretreatment record. and the ability to accent: these changes depends largely on the techniques of quantification. Itil have The studies by Charles ahaaasa, Douglas Goldman and Turan shown that the amount at fast activity can be enhanced if the pre— existing record is one with ccnsiderabla low voltage fast to begin with. It is also clear that if one wishes to bring out the fest the activity following an oral dose of a drug, this can he done byand of of pentothal. accent a specified subsequent administration under this pentcthai activaticn the appearance of barbiturate spindles can be seen earlier than by the naked eye. After discussion with Dr. Itil, I believe that we can carry out the measurements to determine the time at which a barbiturate response appear: and perhspa, its duration by repeating the measurements at subsequent occasions in other subjects. With regard to quantification, analyzer methods available st ! believe that both the frequency this haspital and the newly developed caeputer techniques provide us with measurements which are as deli— cate and aa well defined as anywhere in the ccuntty. In addition, utilized, we are able to carry out if the computer techniques are which have been described by Mtrphree, certain statistical approaches who was also interested in determining the time of cn-set of peutothal effect. �Dr. reroute! 5~9~65 Page Two for the details of the study, I believe it would be necessary to obtain the services of volunteers, requesting that they come to the laboratory late in the afternoon. It would be advisable that they come for a number of sittings in which EEG recording would be taken on each occasion. During the first two recordings, they should be given a placebo; on the second or third, a oooobsrbiturate in an snouut to be specified and this to be repeated in a subsequent sit~ tins. I would hope that the examinations would be taken as a minimum one week apart. and that the subjects not be under any other doom effects. The recordings should go on for a minimum of three to four hours to obtain the oo~set of the drug effect and in some subjects, for tony hours to determine when the record has returned to the base~ line level. I believe it would be necessary to undettake at least ten subjects and preferably closer to twenty to complete the project. As original question, whether there would be differences in effect for anoharbital in 50 as. doses either in a standard preparation or in delayeo action fore - after discussing the problem with Dr. ltil, I so not confident that we could pick up 50 as. and would suggest that if the design is proper, e dose closet to 200 ea. would be more easily measurable. However, we will be pleased to try a 50 mg. dose. The should like to undertake this study during the summer and can do so, since I will then have the assistance of a number of nodicsl students who can participste in the program. we I trust that this answers your inquiry, and takiug such_a study. I look forward to under» Sincerely yours, Pink, ”0 ”a Director Miljb D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Farquhar, John Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-4-371 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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