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                  <text>April 17.

196:.

Dr. Donald F. Kloio

Billside Bospitel

P. 0. Box 38
Glen Oaks. Rev York
Dear Don:

Thank you very much for sanding but} the depression papor so promptly. I
liked your comments, and ooclossd is the next draft. I did, as you roggestsd. tsks out ell tho EEG materiel which was not pertinent to the issue.
The two tables thet you insctted era quite good. The only quostioo that I

have about thsm, it whether it is necessary to include the statistical
values in the table. while the original study we: a random sssignMsnt. the
petisnts that we era not'extrsctiog for the study er: s subotaople which is
not watched. The ststistios. than. are possibly a poor guide to the data.
I think the tables speek for themselvos.
At the

coatsnt

now

stands,

we

prosent a desoription of the bahsviorai

changes with esoh compound. the global ratings, and the rate and reactivity
resonate. I wonder if we could bolster this with some additional data from
tho mood scales or some of the other depression scores. I liked whet you
did in the anxiety syndrome report and it soy be worthwhilo to add some
similar information. Enclosed is a copy of those covariance ennlysos which
were "depression lentititt". Porhaps wo could include some of these or s
teble like this. Also, in the new scales which hsvs been labeled Problem
13. nunbsrs l. 2. and 5 ere depression sensitive just as the rats and toactivity score. It might be hulpful to do s similar analysis for number 1

(perplsxity), or

5

(tension).

I deleted tho EEG ontoriel, I believs the facts proaontod were correct.
Before John left he did a review of the EEG dots with ohlorproostios lions.
and ohlorpromssine tad Keosdrin. Chlorpromalino. in gonersl, produced more
doits and that: activity, 1nd tho amount of hate was markedly dooroesed in
contrast to the combined drug use. As for imiprsoine, to have done many
analyses on tho Hillsida material and on additional experiments bars. This
because much of the expressed EEG changos are ralsted
it a fascinetiog study.
In general, gtvsn a record with considerable
record.
the
to
pre~treatmant
amounts of slots ectivity, this will decrease. there will be some thets
activity and beta activity will appear significantly. In tho presence of s

While

record with slow wave activity already, ospocially in epileptic pstientr.
the amount of seizure activity increases markedly sod one does not see the

�Dr. D. ?. Klein
4‘17—6é
Page Tvn

fan: nativity

Gar computur analynin program. havu been working
couplcttng In analysis of pontotbal. I hope to
art
take lutpramtna ncxt. bacauan I think
is a fascinating compound. Indeed,
I have rand your thaorotical paper only once, and my first impreautau in
that that. may be ton. incarnating unurophyaiologlcal material with tulpraalna
which may fit with you: moduli.
component.

vbry Hall, and U!

now

it

I rand the paper on anxtaty syndromes and found it very clear and interesting.
It is prcclaely this sort of autottal which items necasaary today as the basis
for I buttor undcrotanding of drug action. I don't havq such patients tn out
ward. It the proton: ting, but they probably 3:15: in clinicg and givon tha
opportunity, I vauld 11k: to bring your paper to tha attantion of loan of tht
out~pat10at psychiatrists, haying that thny will try your rccommeudattont.
Thank: one: again for your halp on the deprasatan paper.

Sinceraly yours.
Fink,
Director

Max

amt:
Enc 0

H. D.

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