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                    <text>....

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Prof. Canton Stofonlo
Doportnont of Payohtatry
Univotolty of Athooo School of Modicino
Eginitiou Hospital
76, Voailliooio Soohio Ariana

Athono,

GREECE

Door Cotton:
Enoloood is o copy of tho critique provided by Dr. 8332:.
of tho ounnorioo submitted for that: roviow ct tho and of January.
Thoir concerns noon cannot. and I treat no V111 be able to respond.

to be in Burupo 1n curly April or. still curront.
Assuming your availdbtlity, I am planning to lonvo Gorunuy on
April 11, arriving that ottoruoon. I on avoilobln until April 15
or 16, as I hsvo o locturo in Washington on April 17.
ﬂy plono

roe-n: stating, I dioouoood our publishing mood: with
Vrlt: Froyhoa, tho oditor of Cogngohenoivo Payohlotty. Ho
1: ollowod to 13:3. "toplcnl looozﬂgvolunoo, Ind was intorostod
in publishing all roportl in out or two inouoo of tho journal,
as wall so ro~1oou1ng tho artloloo plus oppoadlooo on o hord~
cover volunn. Ht. roooption'uoo to fovorablc that ﬁt any oon~
older this no a tonllotic oppottunlty.
At o

Dr.

are progressing with tho data anolyoio of tho withdrawal
otudy, and I on optimistic thot I can bring thou. with no.
Ho

I trust

boloro the
My

you how: rlooivod oonfirootion of tho
on May 9.

APA

ottooatotton

boot rognrdo,

Slateroly yours,

m Fink. H096
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                    <text>-;

Marin-m-

18 March 1974

Johns Hopkins Praia

Baltimor-

Harylnnd 21218
Gantlanon:

I ta internutad 1n recounandins ch. valunn, Drugs and ch.
vBrain, aditcd by P. Dinah, 1969 (LC 68~31662). for an: in a
Icaintr. "Brain nnd Behavior," n: tbs Baalth Satancoa Cantor.
Ha: Dr. Bluek intend a incur :ditian? If so, um wenld upprcciato a

trial

aopy.

I! not. picaln

faculty

use and

bill

sand us a copy of the 1969 edition for
an

dirnctly.

sincerely yours,
MIX

Fifth,

HOD!

Profcssor of Psychintry
Contributor

Hrlcis

�</text>
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                    <text>19 Mirth 1974

mm-

H

'1

mm-

pray:

sqmgeup

Charltn sangaau. 3.9.
-Prnnidnnt
Annriann Paychapathologtcal Anaactatian

Rantarn Panamylvanin Psychiattie Inatttuco

Pbiladulphtn, Paunlylvunia
.3.

Dog: Charlie:

ragarwwvz'yww.

Tb
w!

19129

Enclosed

ch: heat at

is

a eopy a! the nouinationl for APPA cumndttccs.
roanllncttoa. cvnryona nominated sccaptad.

my

1;»;

4
$2:

'tw-mx

m

I an 136.06 dnlijhtnd that Ed Saahcv will be eh. Chairman
of the next Frost-a Conﬂict... Enclosed is a lcttur for you and
Ed for your connldnration for thu progrun.
My

‘mﬂ‘ﬂ'm.

best rsgnrds.
Sinunraly yours,

huh-W5-

an,

m ﬂnk' HOD.

‘

mien

1"

"‘3‘"

£9215

rs,

u
2

MW».

-

_

�</text>
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                    <text>19 March 1974

J. Sachnr, M.D.
Dopartucnt of rsyohiotry
Monastiore Hoopitol
111 Ellt 210th Sttoot
Bronx. New York 10k67
Edward

Dear Ed:

Chorlio has told no of your accoptias thatrnunohip of tho
Congratulations!

1975 APPA program.

During the past ﬁve years, I have become tnuorootod to tho
on brain function. In our otodtoo I have
become aoquoiotod with two scientists tron (brood who I would
11k. to rooounnnd to you for consideration in tho program.

affects of bottom-o

David do Hind. H.D., Proton-or ind Chairman of the Dopartn
non: of Phoruooology at tho Univoroity of Utrecht, has been a
voty signifionnt potion in attaining tho role of paptidoa in

unwary function.

is one of his otudonts, who hon been
tho
for
phormooologio
rouponoiblc
assays of a series of peptides
dcrivod from ACTE. He works at K.V. Organon, can, Holland.
zﬁothaof than: non opook oncolloutly, and should you fool than
a prouontozlon from oithor of then would he usaful. I on op~
tiaiatic than they will participoto.
Honk van Bianca, H.D.,

Itil,

I

on

not. you ore acquainted with tho vacant

who has dononntrotod CH3

hormonoo and choir

Again.

my

antagonists.

work of Torso

affects for a variety of so:

congratulations,

and

my

boot rugardo,

sincsroly yours,
”‘3 Fink,
Elicia

MbDO

�</text>
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                    <text>19 March 1974

Albert A. Kurland,
Director
Maryland

Box 3235

M.B.

Psychiatric Raseardh Center

Baltimore, Maryland 21228
Daar Al:

biochemist of uufficlant
I were looking
distinction to tecommand for this poattlon. If Friodhoff
Arnie
at
would
prdbably call
for auch a person, I
College
Einstein
Alhart
Ed
the
Sacha:
at
New York Univarsity or

I regret that I

do

not

With regard to the

ECT

know any

of Mudielae.

rcaﬁ the ropart before
You may be

it

interuatad

project. I would be dellghtdd to
is submitted.
1n

gutting a

envy

o: the newly-insued

volume, Puzchobiologz of Conuulalvn Theragz, which has
published by V. H. Winston in Waﬂhington.
My

just been

best resardn.
Sincerely yours,
Fink, M.D.
yrofunsor of Psychiatry

Ma:

MF/ciu

�</text>
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                    <text>19 March 1974

Edward (2. Sunny. M.D., Ctr-Charm
Drug Abate Coutctunoa
Hhacun of Scinnca and Industry
57th Strcet and Laka Shore Drivu
Chicago, Illinois 60637

national

Dan: Ed:

I vary much rcgrat that I will be unable to att.nd thav
Racianal Drug Abuna Confsrenca. as I am schcdulod to ha in
Europe

at that tins.

I havn no roservntioas 1n ruccmnanding my rcpllcsmnnt at
tho ﬂaw tart Mndical Collage, Richard Rennick, M.D., to subotitutn an my behalf. should you approve, yea may reach him
at (212) 369~7900 or (212) MDZ~1899.
my

best wishes for a succauaful conferencn,
Sincarely yours.
Mn: Fink, M.D.
Professor of Pnychiatry

M?/ois

�</text>
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                    <text>19 March 1974

Isaac Marks,

M.D.

Institute of Psychiotty
do Groupigoy Park
Dcnmork,ﬂill
London 8E5 8A3
EEGLARD

Door Dr. Marks:

First, lot no thank you for your participation in the APPA
settings. You: contribution was vary helpful, and I trout that

you cnjoyod tho ocooiana as ouch on

I did.

I havo rcod the proposed rosoaroh program untitled

youtio Studio: of Booiotant Noutoooo."

"Thora~

yroposcl is an ambitious one and should make significant
contributions to the trootmont of thooc complex problems. From
the point of vicw of poychoohormccology, I can one no inherent
rationale for tho study of clooiprooioo. From the evident: avail~
oblo to no, this is on octivo thymolcptio, prdbably indistinguishable
from imipranino. Tho study will doiino tho efficacy of this
compound and will soroly juotify the invoatuont.
The

the point of viow of nouroohyaioioay, I bcliovo that
in a much stronger position to dofioc tho rolo of
the pharmacologic ngoot in tho trootooot process if you could
specify that brain changooudid or did not occur, the dcgrco to
which tho changoo wore contained, and tho relation to tho troutuont couroo. A: I iodicatod in my lecture, I bcliovo that thorn
in a good tolationohip botwooo bohaviorol changos and nouro~
physiologic offooto in ECT, and with psychoactiVo drugo. Should
you be able to racetd EEG signals in a oyotoootic way, undo:
roooonobly woll—controllod conditions, your cloctrooocophologrophor could quantity tho EEG ohangoo and provide you with an
indopoodout nocouro of drug affect.
From

you would ha

-1-

�rm-

«-..-v

Ava“):

wwmrr

I. Markl‘

19 Match 1974

~2~

M.D.

Should you not have facilitias available at Denmark Hill,
wuuld be glad to coopnrata and provida you with quantifina~
tion of tapes; if these are «ollncaad in a ayatcnatic way. under
canditiana which permit us ca nuke tho measuranant. To c01ldborata with this laboratory would regatta thnt you havu a tape
system cangntible with aura, amplifinrs which era of ransonnbly
high.qua11ty, and a teghniciun who undnrutanda eh. presentation‘
of 339 data for quantitativu mcaaurcunnt. Thar: axe rwo technicians in tha Landon urea and, dhauld.you be intotcntad, I can
string: to: your technician to be superviaod by cithcr of those
um

units which

new

at: caapnratins with us.

During uh: pat: year, I have bacon: particularly interested
Eh.
in
psychoactiva.prapert1us of a tttraeyclic campaund. nianu
auxin (GB-94), praaucad by H. V. Orguuon in Holland.' We bilieva

that niunnariﬁ is

rapidly aetivn than anitriptyliue, with
fiﬂit scdntivu tad taxicholincrgic effects. Should you be intaraatod in alias this compound.rlthcr’thtn annthar in your emu
periunnt, I would be.gind»£o propose to the pharmneoloxistn at
mere

Orgauen that they canaider providing you with such equipnnnc as
gay bu unctul far a cbllabaraciaa.

I

hopu ynur weak;

.My

best rugsrds,

in Israel are fruitful.
,

Sincerely yours,
Max

rink,

M.D.

_

Ptofcsnnr of Psychiatry
Mr/cia
Baal.

�</text>
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                    <text>19 March 1974

Houston,

E. A.

24.1).

Professor of “ontology
Sinai Hospital Bchool of Modicins

Mount

Fifth

How

Awooos and 98th

York,

How

Street

York 10029

Door Ed:

I

wont to thank you

Morris Sandor.

It

for inviting

no

to tho presentation for

in unfortunotc 3hct you second diusppoiutsd

1n the proscntation that Martin and I mode. You mcy toccll that
martin tscoivsd co invitation and I hsd not; and in response to
his toquost. I supported the ptoscntttion of tho 088 material.

I as taking the liberty of enclosing a draft copy of c pros~
notation I had undo two weak: one at c coating of the Amctican
Psychopathologicol Association. Encouraged by the subject of the
contoronos, "Evaluation of Psychothctoptos," I wanted to bring
to tho sttontion of this audience tho work which we had dons
sons goats outlier on tho relation of brain function and psychothcrspy. The theoretical model presented to a b1t.sttnincd,/but
I have no doubt that the continued oxplorntion of tho linguistic,
attitudinal, and pctccptusl changes with psychoactivc drugs pto~
video a spacial opportunity for undsrstaudtng tbs changes in the
dyadic tslctionship, oftcn ussd for thstopsntic purposoo.
My best regards.
Sincorcly yours,
Max

Fink,

M.D.

Ptofcssot of Psychiatry
MF/cto

Ecol.

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                    <text>19 Mnrch 1974

Pollack, Ph.D.
anartnnnt of Psychology
Qunens Callas: of tha
City University of Saw York
Flushing, New York 11367

Max

Dear Max:

I am tuking the liberty of sanding you a copy of the paper
I just presented at aha AP?A. When I was flood with the problum
of developing a prastntation on the gun-r31 aubjcc: of "Evaluation
of roychoeherapial," x alactcd to resnrtacc the work which we did
more

than a daaadc ago.

You nay alto be pleased to know that the valuma, Pnzchobiologz
Canvuluivu
cf
Thornpy, which prosantc the proceedings of an RIME—
supported conlcrnnec in 1972, has just been published. You may bu
planned to sue your work axtanuivnly quoted.
Hy

best regards.
Sincerely yours,
Max Pink, M.D.
Ytofelﬂot of ¥aych1acry

M?/cis
Baal.

�</text>
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    <fileContainer>
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                    <text>19

“3::

L.

March 1974

m, Ptho

Departunnt of Psychiatry
University of Chicago Medical School
950 East 59th strect
Chicnso, Illinois 60637
boar Bob:

I am citing the libarty of sending you a copy of the papar
I just praaaucod a: the AEPA. When I was faced with the prdblnm
of dsvnloptng a prcsentation on the ginoral subject of "Evalustion
of voychochcttpios," I alocted to resurrect the work which no did
not: than a decade ago.
You may also be plugged to know that tha volunn. Pszchobiologz
of Canvulatvn Thargay. which pruacnts the proceedings of an RINK»
:ygportad confgrcnca in 1972, has just been publishcd, You may be
pleased to see your work extensively quotad.
My

bunt regards,
Sinccrcly yours.
24“ Fink; MID.
Proﬂessor of ?¢ych1atry

Mflcia

Encl.

x:-

:rvyympwmn-

.

w,-

.

�</text>
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                    <text>w: “w ...

»

"1»

an.”

«‘

mun,"

a

.__, -r»4(«

-—.-»

”Warwr FW—v‘u‘w’r‘u’ ”v“. w m

19 March 1974

Joseph Jaffe, M.D.
ﬂaw York Stat. Paychiattic
722 West 168th Btrcot
New

York,

Haw

Institute

York 10032

Dent Joe:

I nisand

convocatian.

you

in Boston at tho

APPA

and again cc the Bendor

Enclosed is a copy of my presentation to thc APPA. in which'
I havc taknn the liberty of quoting you dttnnsivqu. I hops that

the

later datt
‘My

havn not

vitiatod the conclusions of

1960.

bﬁlt regards.
Sinccrely yours.
Pink, M.D.
Professor of Psychiatry
Max

MF/cis
Baal.

�</text>
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                    <text>19 March 1974

Robert Spitaar, M.D.

State Psychiatric Instituto

ﬂow

York

New

York.

722

“but 168th Street
New

York 10032

Dcar Bob:

Enclosad is a copy of the raport, "Brain Function, Verbal
Bchnvior. and Psychothcrapy." for consideration for the APPA
volumn.

I shall try to provido a prettcu within the next
cats 30: Zubin's suggastion.

and V11;

few days

I want to take the opportunity to thank you for satting
such a fine matting. If ch. rest of the Association anjoyad
as much II I did. then it was not: successful.
My

beat regards.
Sinccraly yours,
Fink, MODQ
Profcacor cf Psychiatry

M33

MF/ci:

Encl.

up

it

�</text>
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                    <text>19 March 1974

Robert Spitaar, M.D.

State Psychiatric Instituto

ﬂow

York

New

York.

722

“but 168th Street
New

York 10032

Dcar Bob:

Enclosad is a copy of the raport, "Brain Function, Verbal
Bchnvior. and Psychothcrapy." for consideration for the APPA
volumn.

I shall try to provido a prettcu within the next
cats 30: Zubin's suggastion.

and V11;

few days

I want to take the opportunity to thank you for satting
such a fine matting. If ch. rest of the Association anjoyad
as much II I did. then it was not: successful.
My

beat regards.
Sinccraly yours,
Fink, MODQ
Profcacor cf Psychiatry

M33

MF/ci:

Encl.

up

it

�</text>
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                    <text>,19 March 1975

Albert A. Kurland,
Director
Mnryland
Box 3235

M.D.

Psychiatric Bosaarch Cancer

Baltimore, Maryland 21228

has:

A1:

I regret that I do not know any biochemist of sufficient
dilcinccian to recaauand for this position. If I warn looking
for such a person, I would prdbdbly call Arnie Friadhaff at
Maw York Uhivaruity or Ed Sacha: at Cha Albort Einstein 0011333
of Mndiaine.

With ragard to the ECT projact, I would be delighted to
read ch: ruport bcforu it is submittod.

interuutnd 1n gutting a capy of tha new1y~1ssucd
volumn, quehobiqgggy of Connuisivagrhcrqu, which has just bcan
published by V. H. Winston in washington.
You may be

my

bus: ragarda,
Sincerely yours,
Max

Fink,

M.D.

Profnoaor of Psychiatry
MF/cil

�</text>
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                    <text>20 Hatch 197&amp;

Edward

J. Sachar,

K.D.

Departnnnt of ?syeh1a:ry

Hontaftora ﬂoapttal
111 East 210th Street
Etonx,

New

York 10667

Dear Ed:

Charlia has told

me

of your accepting chairnanship of the
Congratulations!

1975 APPA Program Connittae.

During the past twa years, I havn became intareatad 1n the
affects of burnout: on brain function. In our studio: I haw:
became acquainted with tag scientists from abroad who I would
like to command to you for consideration in the program.
David dn Wind, M.D., Protaaaor and Chairman of the Depart*
nant of Pharmacology at the Univnrsity of Utrecht, has bean a
vary signiticaut peruon 1n assansing the role of peptides in
unwary function.
Hank van Biasen,'m.n., is 00G of his atudenta, who has bacn
taspanniblc for the pharmacologie aaaaya of paptidas derived
from ACTH. He works at §.V. Orgaaan, Gas. Holland. Both of
those nan speck excelluntly. and should you teal that a preacn~
nation from nicks: of them would be useful, I an optimistic that

they

will participdta.
I am also sure that

you are acquainted with tha recent work

affocts for a variety of

of Turan 1:11,
sex hormone: and their antagonists.

who has demonstrated cus

Again,

my

congratulationn, and

my

bus: regards,

Sinderaiy yours.
Max

MF/cin

Fink,

M.D.

�</text>
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                    <text>20 March 1974

Thomas A. Bayou, M.n.

Office of the Deputy Diraccor

Divinion of Mauropharmacelogical
Drug Frodu¢ts

Officn of Saicntific Evuluatioa

at Drugs
Food and Drug Administration
5600 Fishers Lane
Rockvillc, Hltyland 20852

Bataan

Dan: Dr. Sages:

'

Ra:

me 8569.

01w63

I havn recaivud additional information with regard to the
placebo natarial to b. used in our studies of OI~63 undar IRD 8569.
Since tho rnvtuw is «£111 in procaca. I nu submitting this add1~
tianal information for your considnration.
slnearely yours.
Fink, M.D.
,th
Pratt-sot of Psychiatry

“Plait
Att.

�</text>
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                    <text>20 March 1974

313 Bun: Duvalopncnt Company
P. O. Box 597
Stuamboac springs, Colorado 80‘7?

Genclauan:

I van undblc to atunnd tho Winter Confarqnun on Brain Emu
my rnsatvauion after paying a d¢p¢ait of
$50.00. I anticipated rtfund of this #09031: but havu not yet
racoivnd one. I balievn my cancallatiou was and: in dun tin».
search ana caudalled
Thank you

for your nttantion in this matter.
Biuearaly yearn,
Fink, 3.9.
Profassor of Psychiatry

Max

Mrlcia

�</text>
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                    <text>20 March 1974

Dr. mad. Garner

M.

Klinilche Porodhung

Enrrmaan

Hoaropsyahopharmnkologie

Scharinz

AG

55
65 03 11

D—l BERLIK

Postinch
GERHARY

Dear Wernar:

Dr.

covur,
work.

I

Itil
am

asked mn~tc send you puma narcan. Under sepnrate
sanding you 10 ampules, as you requastod.

You may

prefer to as: pure naloxona

I will be glad to supply that if

you used.

With

powder

you'will

for

any syatamatic

tell

as

how much

best regards,
Sincaraly youts,
Max Fink. M.D.
Professor of Psychiatry

MF/cis

�</text>
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                  <elementText elementTextId="106916">
                    <text>20 March 1974

Mr. Soonel

Pilate

Dopartmont of Psychology

Boston Univoroity
6o Cunnington Street
Boston. Massachusotto 02215

Pilate:
Encloood is a

Door Ht.

copy of tho

presentation that

you requootod.

otudioo which I haw. quoted worn done more than ten years
I undortook studios of unilateral and bilateral convulsivo thorapy, I did not include lanauogo uoaoutoo. I do not
know of anybody also who has. but I do holiovo that a study using
syntactic and TTR measures in patients toooiving unilateral ECT
should present differences whothor tho cloctrodos veto on the
dominant or nonndoainant homioﬁhoro. It would bu o vary good
The

ago. when

Ittﬁy

0

Good luck in your studios and my best regards to Canon
notoky and Allen Miroky, ohoold you know them.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

HF/ois

ﬁnal.

Kor—

�</text>
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                    <text>20 March 1974

Robert DuPont, M.D.

Dirootor
SADDAP

and HIDA

726 Jackson

Placo, u.w.

washington, D.C. 20500
Dear Dr. DuPont:

days ago, I received an inquiry from Jon Volavko, H.D.,
hood of tho nourOphyoiolosy division of the Department of Paychiatry, Now York Medical College, regarding ohargos for pro~
cousin; of EEG data. He indicated that he had proposed to SAODAP
that his laboratory process rocordo in tho SADDAP Collaborativo
Hothodone-Lovomothodyl Study. As a juutifiootioo for his budgetary
request, be indicated that using our facilities Would cont $100/hour
for machine time for processing.
Two

I um'writing to indioato that thin to a gross error. This
laboratory was established by tho ﬁattonal Instituto of Mbntal
Health. and no have prooooood data of intorost to that Institute
as wall as to NIDA at oithor no direct cost; or, where funds were
available, at rates from Sllrocord to $5.50/hour. HSMThe latter
é2~70—98,
chargo in tho one that has been used in Contront
and is well bolow the ontinato approvod by the contracting of~
ﬂies: in 1970.

In July, 1973, following mootingo of tho V.A. Study Group
and Morhodono, I submitted a letter, dated July 27. 1973,
to Dr. Sam Kain indicating tho costs which I projectod would be
incurred in oollocting and procoaoing tho V.A. lovomothadylvmotha~
done data. A copy of my budgor of that dato is attached. You
will note that the principal coat in equipping the laboratories
for proper recording. Hora, too. on indicatod that our cost was
$5.50/oooh1no hour, but booauoo of the proposed duration of
rooordinso and tho mothod of collection. we oorioatod a cost of
$1,000-1.200 for 90 Iubjocto rooordod at 4 separate occasions,
ouch occasion of 30 minutoo' duration.

for

LAAM

~1-

�" --- yr

"V" n-

pr-w"an n:

:m‘w’v-HI- vk-‘v‘r'v-

quuat-‘wwr-K

1w. mu...“

. .

,. ”Fm.

7’

.«ﬁ...~....w,....(_m',_....,,d_w..

WA.

.31....

W

‘-.,

”M. Mr r.rr.w--.‘~,

.,._.

,vn “my",

21.... be advised that this not: is vrtttan not as an offer
:9 pgrtieipace in your study program, but to elnrtfy a groan dis—
tortion in quatacion 3560 by my format unionists. I would be
{ztnt;fu1 1! yam vauld dirncc this information to tha appropriate
offiuor in your organisatiun so thgt tha records can be enrrecccd.
Sinccraly yourt,
Hm:

rink.

H.D.

Protannor of Psychiatry

HI/ais
Baal.

�</text>
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                    <text>n—

A

w

20 March 197&amp;

..

....

..,

vawmwp...

‘M:-'r_lw'il‘."";'wnv'~.

Mt. Snmnal

Pilato

Department of ?Iyeholegy
Boston University
6k Cunningtan Straat
Boston, Mustachunutto 02215
Dear Mr.

Pilato;

Encloaad

is a

copy of the

prosantatian that

you requcoted.

studies which I ha»! quoted were done morn than ten years
I undertook studias of unilnteral and bilateral conago.
vulsivu thurupy, I did not includd language measures. I do not
know of anybody also who has. but I do beltevu that a study using
syntactic and TTR austere: 1n patienta receiving unilateral ECT
should praacnt differences whether the aloctrodea word on the
The

When

dominant or nonudomiunnt hanisphcta.

.tudyo

It

would be a very good

'

luck in your atudiaa and my best regards to
notsky and Allan Mirnky. should you know them.
Good

Conan Kor—

Sinceruly yours,
Max

Pink,

M.D.

Protassor of Psychiatry

MP/cis
Baal.

�</text>
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                    <text>21 March 1974

Gerald L. Klerman, M.D.
Erich Lindemann Mental Health Center
Government Center
Boston, Massachusetts 02114
Dear Gerry:
Thank you for your kind comments regarding the APPA. I
think that the Association should consider the suggestion of

developing

its

own

journal.

I have taken your suggestion of a review of the ECT literature to heart. I had completed a review of the proceedings
of the conference on ECT and will now add to it a specific re—
ECT

clinical results.

view of the

Thank you for your suggestion.

In talking to you about yOur relationship to the FDA, I
because, as I mentioned my letters
to Gardner and Scoville regarding the use of ele—trographic
measures for bioevailability, you seemed never to have heard
of this question. In checking my files, I find that my letter
to Gardner of July 16, 1973, and my letter to Scoville of December 20, 1973, have not been answered. My files indicate that
I sent a copy of both to you on December 20. Perhaps one of
the actions of your committee might be to provide closure to
suggestions such as this, for at least it will mean that some
consideration has been given, even if rejected.
was momentarily embarrassed

Again,

my

thanks for your comments.

My

best regards,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF/cis

�</text>
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                    <text>21 March 1974

“.30
Wt.
mm
km:
Bayville, in for}:
3&amp;3
11

11709

Boar John:

I uhumd the EEG “:91: shown to an by my staff.- 911119
the frcqmuies an irragnlar and the voltages variab 1e, I an
not an anything thick, by itself. would ha considered patho—
logical. If ch: “:23“: 1| umtmtic, I would so no forth”.
than ha nhauld be can: to an ”‘If an sum-at 1: amt-matte,
propriate adieu).
ﬂy

but

”non.

raga-ch.
Sincerely yours ,
Eh:

Mg Mon.

Profauor cf Psychiatry
I!!! at:

�</text>
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                    <text>21 March 1974

José A. Yaryura~robias, H.D.
Secretary for Scientific Program
Asociacian Argentina d. Paiqnintria Biologic;
Parana 866/868
nuance Lites

REPUBLICA ARGENTINA

Dust Dr. Yaryura~Tbbiaa:
was pleased with your response to my inquiry and called
your nocrntsry to tall but that an would not up andh a program.

I

I have invitad eight participants; to far, five invitees havn
acccpted and on. has ducltnnd. I an awaiting the additional
tuspansca and hav. caupleted tho prapatation for the program.

I U111 write to you as soon as the panel has baen structured.
would
I
appraciate you: schtdnling the session on quantitative
EEG and psychopharnacoloxy.
Sincerely yours,
Ha: 316k,

3.9.

Professor of Psychiatry

Elicia

�</text>
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                    <text>21 March 1974

H E H

0

R A H D U H

To:

Arik Briaaandan, H.D.

From:

Max

Fink, H.D.

sabjact: Additional Funds (FY-74, 6th Qtr.),
LAAH vs. Hethadane Cooparativu Study
Additional funds in the amount of $6, 3&amp;0 have been

made

availabla for the tasting of brain changes of patients raceiving
levnlathadyl and mathadaac.

We have requested an EEG machine from General
Hospital
Equiplnnt, and these additional feuds should be used for the
following items:

1

Hewlettérackard tapa recordar, FE,
A-channnl, Model 39603, plus rack
mmt...‘.t..l.....DO...U..OOOOOOOO'OOI$‘585.00

l

Oscillator, Eewlett~Packard,

1

Oscilloscopa, Kawlett—Packard,
dual beam, Model léOB plus time

frequency range, Mbdal

m We].

low

20262..........

375.00

I‘GSA.0.0.0....IOOQIIOCCOOQ 1250.00

$6010.00

In addition, we will raquire the balance of the funds to be
used to purchase some small piecea, such as a tape degausaer,
couch, table, etc., which may be required in ordar to establish
a fully functional laboratory. A raquaat for these items will
follow, pending the purchase and receipt of the principal itaas.
HF/cis

�</text>
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                    <text>yaw/4

e

“mu-mvnwu—WWW—wvw

4-7.

w'wr’y'Wv"

.w .m'u—m-e-wr-n

—-..

m

m Int-new"!
r.

7,7

w

~r

mwm “aw—”wr—Wr.

"DJ-Hm

w.

Im‘er—vr

.m

.~

.v

March 22, l97h
Abba

Kastin,

M.D.

Endocrinology Laboratory

VA

hospital

New

Orleans, La.

Dear Abba,

I have read the latest protocol for the "ACTH h-lO study
of perceptual threshold and attention in humans" by Sandman, George.
and Ksstin, and will be pleased to submit this to the FDA. There are
some additional data that ought to be included, and I have indicated
some suggestions in my marginal notes.
The FDA has

studies (see

requested a progress report on the 01-63

letter enclosed). I

or your reports to

would

like to submit either a

copy

Riesen; or, a short summary of the data.
including numbers of exposures, dosages, tests employed, and a
description or the results. Either type of report will be acceptable,
I believe, and I will leave the choice to you. I am sending the same
request to Lyle Miller and Joyce Small.
Bank van

I have received a

copy

of the Miller et al.summary of the

earlier study. I find the results interesting but the absence of

the data

weakens the presentation.
him with some marginal notes.
Good luck

I have returned the original to

in your studies.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry
Max

1w -. P-v'nrr—w'yv'w it"s-WWW.” “to

�</text>
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                    <text>W

m-u—y

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(r'r‘w-‘swnww—an'q-‘vurm -~.—-\ new“

March 22, l97h
Henk van Riezen, M.D.
N.V. Organon

Oss, Holland
Dear Henk,
am

I look fbrward to visiting with you April 2-h,
writing to bring you up-to~date on a few matters.

and

I

1. Before submitting the supplementary information on
the 01-63 placebo to the FDA, I called the FDA as it has been more
than 2 months since we submitted the original data. They have not
made any determination, so I sent the additional data. I will
have to call them again if we wish a response.

I called Joyce Small about a report. She has sent you
week. She is now finding effects that may be
drug—related and she is testing additional subjects at the 15 mg
dose. I received and sent to her, the additional supplies of OI~63

one

2.

earlier in the

she requested.

'V‘V‘I'E'

In talking to her, I raised the question of EEG effects
of chronic administration of GB-QL, suggesting that we would analyze
her reqords for comparison with our studies of the acute effects. She
was not enthusiastic, pointing out that her tape system was incompatible with mine. Rather than proceed against her initial Objections,
I deferred the discussion until we have had an opportunity to explore
the need and the alternatives.

“.1

a...”

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studies of

3. The

01—63.

Abba and Lyle.

has asked for a progress report of our
I asked Joyce for her data; and I have written to

FDA

h. Your review of the Miller report was so thorough that I
could not add much. I was also disappointed in the report and I have
sent it back with some marginal notes supporting your comments.
5. Hastin has sent a new protocol for a study with Sandman
and George. I find it incomplete for filing and I have returned
with a request for the additional information. I will bring a copy

it

with

me.

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vanRiemnOIOOOIOOIOIOOQOMarch22’197k IOODIIOOOOOIOOOOIIpageZ

visited Dorothy Krieger on March 15. She had
received the materials from Organon that day and was most pleased.
She described her program to me, and I found her more interested in
the periodicity of the phenomena and the clinical applications than
in any theoretic or psychologic phenomena. We could not find a
common groun for interaction but left with an agreement that should
we find something of interest we would contact one another.
6. I

and

7. Dr. Strand called me before she left for Europe,
I sent her the high dose (90 mg) OI-63 data from my laboratory.

The rest will wait until my visit. My best
please schedule sunshine for the first week of April

regards——
!

Sincerely yours,

Max

Fink,

N.D.

'

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7458-094

mrch 26,

1974

RED

P. 0. m: 28083
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ImﬂdlikaU.S.officia10rderfmforSdnduleIISub~

mmmimeim No. PF 0101701.

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Amofﬂmtmgistmtimiamlosedﬁormgndame.
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mProfessor
of Paydﬂatzy
M.

Wmd
Em.

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March 26, 1974

Craig

D.

Darrell,

M.D.

Chairman, Sectim of Biological
and radical Sciences
'1?» New York Madam! of
2 East 63rd Street
New York. N. Y. 10021

Sam

1388101319:

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Scimmtingmhprﬂ
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Fink,

M. D.

Professor of Psydxiatry

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                    <text>74%09583

W
of
Wat
adversity of
St.

27 , 1974

Dr. D. P. Bobon

Psychiatry

Sumo).
Meal
34000
58,

11396

Rue
Laurent.
Liege, Mame

mar Dr. 30mm

I read your article

on the

"Classificatims and Tarmimlogy of

lenﬂthrie,

of
in the
of haterest. I think your paper highlights the paverty
with a. great
for so many
of the miptive msologms. That it has hem
mnfor
so many
authors to develop so many descriptive term,
an
appmadm.
I
fleets the lack of merit of a molly plumnlogical
with
that you, who have had
writing bawuse I was
Us
seems
0f
than. It
m
electmpsycmlogical memes, nude so little
by changing brain fmction.
that psydnactive 611198 :30 affect
Brain fmmtimmasxmeaarepoor, withtlwbestbaingms. Aspooras
EEG
they still provide the best classificatim of
are,
Psydmotropic

{Danagazu

(Real

W33m,

January 1973 5.38%

W

61me
mm
Mr,
W
Wﬁwmmamewmmmﬁimtmamt
the
failures. Immzindedofthesaymg, ”Intkmlandoftheblind,

one—Wmismng, - forthisisthemyi mmcmamications.

Wt-

Ilamﬂmtyouarexmdoingmssmﬂiasmﬂlmﬂﬂmthat
for classification, after

you would come

to use mesa magma

mgsomllthattmdemiptivatmmomoftheﬂmtmtyyeamis

socmfusing.
My best regards.

Sincerely yours,
Fink, M. D.
Profaasor of Psychiatry

Mm:

�</text>
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                    <text>March 28 , 1971;

Jonathan 0. Cole, M.D.
Boston State Hospital
Boston, Massachusetts
Dear Jon,

Enclosed are some of the forms that we are now using
to maintain alertness in our subjects and to assess changes in
behavior during our phasewI EEG classification trials. Our
principal method of assessing behavioral change is to ask the
subjects to open their eyes every h minute and 20 seconds (and‘
to keep eyes open for ho seconds), asking: "Do you feel any
change ?" Alternate inquiries add,
"On

a scale of

—6

to +6, would you rate any change in

your state of alertness (awareness)?" The subjects are told at
the onset of the experiment that their present state is to be
rated as '0’.

The symptom questionnaire is used befbre, at the mid~point
of the experiment, and after the experiment is over. Examiner asks
and notes responses.

a self rating completed by the subject before the
experiment, at the mid—point, and at the end. Rating is either by
hand or by computer program.
CMS:

Irwin inquiry: an open—ended sheet to maintain a running log
of the subject‘s behavior, answers to questions, movements, etc. In
the left columns, time is noted; 'as' is the alertness score given
by the subject;'bz' is the number of times a hand—held buzzer was
released during the previous time period; and '123’ reflects another
scoring estimate used by us in examining the effects of benzodiaz—
epines, and not relevant for your work. Page 2 of the inquiry is
completed at the end of the experiment.
From

this range of behavioral inquiries,

we

believe

we

have teased out some aspects of the subtle behavioral changes in
our subjects when we have used threshold doses of novel and established
compounds.

I

trust these

comments

are helpftl.

Good

luck

!

Sincerely yours,
Max

Fink, Mb.

�</text>
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                    <text>ThSB~IOOBB

March 29, 19Th

Bettie MbLeod
Clinical Psychiatry

M8.

Hews

h907 Cordell Avenue
Whahington, D. C. 2001b
Dear Ms. MbLeod:

Enclosed is the galley proof with some corrections. I
have added a paragrayh which may put this presentation in a broader
context. One paragraph is marked as ”out of context" and probably
should be deleted.
A

Be

photograph

is included far your use.

sure to send

me

a copy of the newsletter.

Sincerely yours.
Fink, M. D.
Protesaor of Psychiatry

Max

Merd

Enc.

�</text>
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                    <text>April 11, 197h
TAMARATH K. YOLLES, M. D.
MAX

FINE,

M. D.

Alpha~0mega~Alpha

As e member of the New York University Chapter of
Alpha-Omega-Alpha, and a member of the faculty of S. U. N. Y.

at Stony Brook, I am pleased to support the application for
a charter of ADA for the School of Medicine of the Health
Science Center of

this University.

Fink, M. D.
Professor of Psychiatry
MEX

MF:ed

�</text>
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                    <text>ThSB—IOBSB

April 11, 197h
Mrs. Gail

M.

V. H. Winston

Parker
&amp;

Sons, Inc.

Street, N. W.
washington, D. C. 20005
1511

K

Dear Mrs. Parker:

I would appreciate your getting the following informa~
tion to the responsible officer at V. H. Winston:
I have been asked, by Science, to review a volume of
Convulsive Therapy published by Walter Eeemen. Indoing so, I indi—
cated that

more

of the issuee raised by Dr. Eesmen were discussed
extensively in "Psychobiology or Convuleive Therapy".
some

Miss Sylvie Eberhert is the responsible person in the
book review department of Science. If a review copy of our
tolume has not been sent to Science, 1 would appreciate that
one be sent to her at AAAS, 1515 Massachusetts Avenue, N.W.,
Washington, D. C. 20005.

Sincerely yours,

Merd

Fink, M. D.
Professor of Psychiatry

Max

�</text>
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                    <text>WM

April 11, 197k
Dr. Milton Kletzkin
h? Gage Road

East Brunswick,

N.

J.

Thee—10183

08816

Dear Milt:

I have Just returned from e moat stimulating trip to
Europe. While in Holland, I met with friends at N. V. Orgenon,
a pharmaceutical concern now actively involved in psychophermeeology. They are interested in exyending their programs. Should
you be interested in working in Europe, I would suggest that you
send a copy of your Curriculum Vitae to Honk van Rieeen, M. D.
his co~workere are among the finest
I have been associated. They have unusual
compounds and investigate them for human trial by the most edveneed methods. It would be fair to say that I know of no other
concern which would provide as fine an opportunity to work
Dr. van Riezen end

scientists with

whom

imaginatively.

Following my visit to Holland, I attended a meeting on
computerised EEG and met Leo Goldetein there. At breakfast, «he
shared with me your wish to leave your present laboratory.
My

best regards.
Sincerely yours,
'Mex Fink,

MF:ed

cc:

Hank van Rieuen
N. V. Orsenon
OSS

Holland

M.

D.

�</text>
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                    <text>12

April

197%

ARIK BRISSEHDEN, M. D.

V. A.

MAX

Hospital

'

PINK, M. D.

Treatment of Chronic Schizophrenia with Oral Hypoglycemic Agents

his

I have read the protocol submitted by

co—workers, and would approve the mission.

Dr. Messinger and

There

is a theo«

reticel objection to this study, since ineulin come therapy has
been found to be thoroughly ineffective in the treatment of
schizophrenia. Hypoglycemia may not alter cerebral activity until
levels lower than

achieved fOr extended periods.
For both these reasons, I would assume that the treatment yroposed
is essentially a placebo thereepy with smell additional risk.
30 mg% have been

However, the risks are small, even acknowledging the
caraiovasculer risk assessed by Dr. Fritts. If we acknowledge
that the therapeutic effect of enthusiasm of the observer and
systematic observations may be mobilized for the treatment of some
patients; I do recommend approval of this project because I believe that Dr. Messinger will be stimulated by his enthusiasm and
we can anticipate some discharges from the hoepitel using this
regimen. I would be less sanguine about their finding meaningful

scientific data.

MF:ed

-

�</text>
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7h8B~105SB

April 12, 197h
Albert

A. Kurland, M. D.

Maryland Psychiatric Research Center
Box 3235

Baltimore, Maryland 21228
Dear Al:

I share your concern regarding the reduction in psychi-

atric research support, particularly the negative impact which results from concerns regarding the "rights" of patients. I am sure

you know of

the severe reductions in programs at the Missouri

Institute of Psychiatry. The two senior scientists, Turin Itil
and George Ulett have left and their work has been severely curtailed.

At this Institution, we have been unusually fortunate,
for our programs are new and the excitement, enthusiasm and expertise of a new faculty serves to expand our research programs
with minimum impediment. we have been called upon to participate
more actively in faculty committees, particularly those related to
research and teaching, than any of us had been called upon in prior
years. we consider participation in the committee systems critical
to our salvation.
So as to complete the national picture, the reduction in
support for psychiatric research apparently includes reduction in
industrial support. I have received any inquiry from Milton
Kletzkin of Wallace Laboratories seeking advice as to a new position,
as the research programs have been severely curtailed.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

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ThSB-lthB
April 19,

lQTh

Larry R. Squire, Ph.D.

Assistant Professor of Psychiatry
veterans Administration Hospital
3350 La

Jolla Village Drive

San Diego,

California

92161

Dear Dr. Squire:

are probably correct, that {cllov-up studies of
relatively insensitive memory tests. In our
work at Hillside Hospital, l95h—1962, and at New York Medical
College, 1967-1972, we have not looked at long term effects
systematically. In one study, our fellow—up was lO—lh days
after the last treatment; another, the last week of hospitali—
zation which varied from 2 weeks to a few months.
You

ECT

and

have employed

Teuber

is

I did study the

to your usestions.
The

EEG

condensing some recollections.
EDT

Pollock
would
data
not relate
but
our
process,

date was published by

M.

A. Green

in the

Journal of Hillside Hospital, 6: 229, 1957, and Journal of
Nervous and Mental Disease, M3: 117, 1960.

You may be interested in checking the summaries of our
work published by my co—workcrs and myself in "Seminars in
Psychiatry", volume h, No. 1, February 1972; and in a new
volume entitled "Psychobiology or Convulsive Therapy", pub—
lished this month by Winston and Sons. I am enclosing an ad—
vertising sheet for your interest. Should you find references
in either volume that are of particular importance to you,
please do not hesitate to write.

I
know that you are cognizant of the special problems related to)
differences in memory function measurements based on whether
they are visual or auditory, and their sensitivity to practice
I think your study is s very important one,

and education.

and

.

�I would be pleased to have the opportunity to read
the reports as they are submitted for publication.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

Enclosure

'

’

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                    <text>.;'I~v*‘

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April 29,

W

&lt;—wylw"ww‘7'wm"w‘.—wm&lt;w-v

we,

”we

S. Karger

lQTh

AG

Herstellung 2
CH h011 Basel
Switzerland
Gentlemen:

I have reviewed the page proofs of the article,
Profiles and Bioesailability Measures of Psychonctive Drugs,
to appear in Itil's volume, Psychotropic Drugs and the Human EEG.
Except fer the correction for the degree of Peter Irwin, I

EEG

{bond no typographic

errors..

4"(‘ew1'vnn‘l'w

"-1

"r.

\Pages

81—8h

have been

should be part If
not appear as part of the
reset of these pages, and
the lines suggested, with
1 and 2

page 83.

laid out poorly. Figures

the section, Fentluramine, and should
doxepin section. I haxe attempted a
suggest that you reset the pages along
figure 1 on page 82 and figure 2 on

Thank you.

Sincerely yours,
Mex

cc; T.

Itil

Fink,

M.D.

Wm,

,,

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lucrr

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                    <text>April 29, 197k
Mr. Herman Weissman
Hoffman— La Roche Inc.

Nutley,

New

Jersey

07110

Dear Hank,

Enclosed is an original, unbound copy of the report
summarizing our experiences in assessing the EEG profile of
bromazepam and its comparison with diazepam and placebo; and
the blood level correlations. I am also enclosing three bound

copies for Phil

Bookman and

other associates.

Please be advised that the original data of the EEG
assessments, behavioral observations, and subjective data are
in our files and may be made available at your request.
I want to take this opportunity to thank you and your
associates for your cooperation and patience during this study.
I believe we have made some progress in characterizing the pharmv
ecology of these compounds, and in the process, we have learned
a great deal about our methodology.
My

personal regards.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>”m my.WWW

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7hSB—1188B
May

Prof. Dr. Antoine
LEHA

L8

1,

lQTh

Remand

Salpetriere

hT, boulevard de 1 Hospital

F—7563h,

Paris

Cedex lS/France

Deer Tony:

I very much enjoyed the discussions at the GEAR. You seem
surprised that we, in America, were already making direct applications
of computer methods for clinical purposes.
In my report, I lescribed two applications to clinical psycho~
pharmacology which are ongoing in my laboratories. At the same time
as I was working on this program, Prof. E. Roy John and my co-worker,
Dr. J. Valeria, were developing a computer—based Neurophysiology Clinic.
A description of their application
is enclosed as you requested. When
I inquired last week, I was told that they have a waiting list of more
than two hundred who seek this service.
EW'best regards.

Sincerely yours,

MF:ed

Enclosure

Max Fink, M. D.
Professor of Psychiatry

�</text>
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                    <text>.W
rm—ymw-w my“7,mum. ,...
.

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V-..“
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r

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i»

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“75F...

,

‘

May

2:;

1971*

Dear Milt ,

E

.

I

relationship with the
acquainted with their programs. The
director for research, Donald Klein, is a well—known clinical
psychopharmacologist with an interest in psychopathology and
clinical trials. He is not particularly focussed in basic
science approaches, leaving the medical aspects to an
internist, Arnold Blﬁmberg, and the neurophysiology to a
classical, descriptive electroencephalographer, Struve. I
would not be sanguine that he has an opening, but you may
wish to call him and inquire. You may cite me as a reference.
While

,
a

ww1-y,‘m.w—wr—ymnu-wv—n-w

.m—wmw—“I—I—r“
r‘mm—‘w-m

‘n'i-‘w—

“A.“

no longer have a formal

staff at Hillside, I

Europe.

I

am

am much more

Good

impressed with the opportunities in

luck.
Sincerely yours,
Max

Fink ,

M. D.

1r.

-

v......-v y-—ra:¢m'ﬁw-'_

�</text>
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Hank van Riezen, M.D.
H.V. Organon
Oss , Holland

Dear Henk,

I have received the extensive documentation for the

report and I thank you. I will get
you a copy before the meetings.

to

it

01—63

next week, and will send

I regret that I felt I had to disturb you at home last
it seemed prudent to report Joyce's concern. I am scheduled
to visit her on Tuesday, bay 7, and I will report fully thereafter.

week, but

The report to the ECDEU will be sufficient for the FDA. I
realize Kastin’s concerns and I have no need or desire to increase
his anxiety. I have sufficient data now.

in your letter of April 17 sent me to a
associates. The best laboratory to assist us in the
analysis of the behavioral data of the 63-91; study is probably
the Biometric Laboratory of George Washington University. This
center was established with government funds and is supported by
a large contract to develop methods for rating behavior and to assist
investigators. The directors are friends, Ronald Bonato, Ph.D. and
William Gw, Ph.D. Before recommending them, I screened two other
units: the VA laboratory at Ferry Point under Dr. James Klett and
the laboratory of John Overall in Texas. I believe the best unit
for our purposes is that of George Washington University. I met with
Bonato and Guy at a meeting in Wshington yesterday and they agreed
to review the data and to offer their advice and support. I also
met with James Klett, who will be able to meet with us, but is
unable to help with the data. Should you wish to send Dr. Stuhlemeyer
to the U.S. , I would be glad to arrange to visit Washington with him.
number

One comment

of

11V

to

it

to come
to Florida, to attend the
the discussions. He could spend some time in Washington thereafter.
He should bring copies of as much of the data as is representative,
with as many of the analyses that have already been done.
Should he wish

come,

ECDEU

would be

helpful for

him

sessions and to hear the level of

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.....................pg. 2

As for the costs, there is some problem. Officially,
the Biometric Laboratory is not organized to process data fer
industry, but for investigators. They will analyze the data if

it is listed as coming
if you obtain releases

from an investigator (such as nyself); or
from each of the participants. They cannot
charge a fee. Should they assist you (us) in a meaningful way,
id possible for me to reimburse them for their time. I would suggest
that you allow an initial budget of $1,500, with the guidelinethat

it

pay a consulting fee at the rate of $lSO/day. Should their
contribution warrant, I can clear the payments through you in advance.
(Should their contribution be considerably greater, I can suggest
the amount be increased.)

we

As

for the other notes: I will write the GB 9h protocol
will include the collections suggested by Dr. veen.

next week and

series of studies in the neighborhood
schools, in which the teachers refer children with behavior problems
and reading disability. He and his wife have a team examine the
children, evaluate the clinical condition, and then assign the
children to systematic studies according to the diagnosis and
according to their protocols. These involve administration of
placebo, drug, or comparison drug for extended periods; with
psychological test, clinical behavior evaluations, teacher and
parent ratings, etc. at frequent interviews. The program has
developed data on dyslexia, eneuresis, phobia, hyperkinetic
states. Their clinical and psychological data are excellent; their
Donald Klein has a

physiological measures need improvement.

is still in
Israel; has received my letter; but indicates that he will not be
back in London befbre July. He is planning studies to begin next
March/April, and.vill surely write to you this summer.
I

send

met Dr. Marks in Washington yesterday. He

Please excuse the typographic errors, but I decided to
be back in my office until

this off myself because I will not

next Thursday.
My

best regards.

Sincerely yours,
Max

Fink ,

M.

n.

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May

Robert L.

Spitser,

3.

197*:

M. D.

Director, Evaluation Section
Biometrics Research
State of Rev York

Department of Mental Hygiene
722 West 168th Street
New

York, New York 10032

Dear Bob and Jean:

Criteria
I have read the sﬂhmission of ”Research Diagnostic
A

'

formidable produc—
for e Selected Group of Functional Conditions".
tion! Congratulations!
While the details are necessary, I find the descriptions
complex and "phenotypic". By that I mean that the clues which have
come from genetics, and the lesser clues from neurophysiology, and
the response to treatment. are not included in the classification.
Considering the state of the art, this may be necessary, but I
would be more enthusiastic in applying this classification if there
were ways to include the suggestions in the evaluation.

principal omission is the response to prior treatment
and the response to a therapeutic trial in the present classifica—
or hypo—
tion. The response to lithium by those with manic illness
from
the
nsnic episodes may he used to separate these two groups
schizophrenics. Some scientists claim that the response to ami~
triptyline is of diagnostic value in bipolar depression. In the
The

that Don Klein and I did more than fifteen years ago,whoververe
reconvinced that there were sub-groups of the mentally
sponded differently to phenothiasines and impramine. These comments
should be enough to suggest that the response to therapy may have

work

some

ill

place in the classification scheme.

o,‘

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757.7”

With regard to your specific question, I never use
"ihnic Illness" and "Hypomsnic Episodes", for I was taught that
"mania" is "mania". I also find the syndrome "Schizo-affective

type", difficult to differentiate from manic ill~
ness. I
if the difference between "minor dysphoric illness"
_end "dysphoric personality" is not 3 case of nitpicking.
disorder.

manic
wonder

With regard

to Items

1h and 15, I think alcoholism
e sub—type of drug dependence.

is not

I find
s separate disorder, but is
"drug
"drug
dependence. opiate type",
useful the classification
dependence, alcoholic type", and "drug dependence, mixed type".
has suggested that "homosexuality" not a diagnosis of mental disorder, I would accept this View.
As

the

APA

These comments are not to be interpreted as criticisms,
fbr I think you and your teammates have done a splendid Job. I
would be pleased to see the versbon after the next review.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

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7hSB~1238b
May

10, 197h

Mrs. Mildred K. Lehman

Chief, Mental Health
Rational Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
_

Dear Mrs. Lehman:

I very mtch enjoyed the conference

on April 17, 197h, and

I am indeed grateful fbr the tape. I have already received a number
of calls and letters tram "patients" who read an overuenthusiastic
summary which appeared in a Chicago newspaper.

I hope the meeting served a useful purpose fbr
glad to have had the opportunity to participate.

NIMH

and was

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
M3:
MF:ed

,

n-

-

FW "

7"

"'

�</text>
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                    <text>/

3W
SBYH'12SSB
May

Bruce Richman,

10, l97h

M. D.

Department of Psychiatry

Duke

University of Psychiatry

Durham, North Carolina

27710

Dear Bruce:

pleased that Dr.

I cannot

you
tell
Faun

how

Our move

to Stony

Brook has been

delighted I

am

that

you have been so

has invited you to go to Houston. I do not
know the kind of work that will come from Houston, but for many years,
I have known of studies undertaken by Dr. Heil Burch and the Houston
State Psychiatric Institute. His work is outstanding in quantita~
tive EEG and you may wish to visit him once you are in that City.

audiessful.

The

laboratory

is running well and Peter, Ira and Maureen are the mainstays of the
lab. We are very interested in the relation of EEG to blood level
of drugs and hope to make acme contribution through this effort. The
studies run well and our principal difficulty now lies in the statistics rather than the data collection.
Should you find yourself in the east, come and visit; and
should you find the heat and the reactionary thinking of Telas too
much for you, come back to work in the heady free climate of the
eastern seaboard. Whenever someone tells me he is going to the miduest or the south, images of my feur years in St. Louis thrust them—
selves into my consciousness, and I am reminded again and again of
the stubborn, reactionary and preJudiced attitudes of the community,
in which I worked. This attitude was not limited to the locals, but

included the professionals at the University as well.
Again,

let

me

congratulate you on your progress and wish you

success in getting your doctorate soon.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

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                    <text>v
7588-12683
May

10. 197k

Mr. Vincent Keely

23 Samoset

Street

Dorchester, Maine 0212h
E

i

;

;

Dear Mr. Keely

I regret that no-mechanism exists fur weekly payment for the
volume of Convulsive Therapy. may I suggest that you set aside the
sum you would have sent in a Jar in your bedroom, and when the
requisite amount is available, purchasing a money order at the Post
Office. This will provide a less expensive and more direct way of
solving your problem.
Good

luck.
Very

i

Fink, M. D.
Professor of Psychiatry
Max

MF:ed

truly yours,

�</text>
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                    <text>May

Richard Phillipson,

M.

10, 197h

D.

National Institute of Drug Abuse
Rockwell Building
llho Rockville Pike
Rockville, Maryland 20852
Dear Dick:

I could not help overbearing your recommendation of a
candidate for residency to Jon Cole during the Anxiolytic meeting.
K

As I am writing to some friends describing a fellowship in
this Department which has Just been created, it occurred to me that
you might have other friends from England vho write to you looking
for opportunities in the States. I am taking the liberty of send~
ins you a copy of a memorandum which deacribes the opportunity.
Should you have a candidate whom you may care to recommend, I will

be grateful for your recommendation.
My

best regards.
Sincerely yours,
Me: Pink,

MF:ed

Enclosure

M.

D.

Professor of Psychiatry

�</text>
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May

10, 197k

Burtcn J. Goldstein, M. D.
Dapartment of Psychiatry
School of medicine
P. 0. Box 875
Biscayne Annex

Miami,

Florida

33152

Dear Burt:

I was pleased to have an opportunity to chat with you in
thhington at the Anxiolytic meetings. I am taking the liberty of
enclosing a memorandum describing a fellowship which has Just been
established in this Department. You indicated that you had appli~
canta seeking Jobs.

criteria stated in this description,
grateful if you could bring them to my attention. I look
fbrward to visiting with you in Miami later this month.
I

Should any meet the

would be

Sincerely yours,

an: Fink,
MF:ed

Enclosure

"an:

.mnﬂn'r

M

”yawn-mt”

a;

aasemr....

Maw

M. D.

Profbssor of Psychiatry

�</text>
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                    <text>May

10,

197%

J. Poppl, M. D.
Institut fﬁr Datanverarbeitung

S.

der Gesellschaft fur Strahlen—

and Umweltfbrschung

Arabellastrasse h/l
8‘MUHCHEH 81
WEST GERMAHY

Dear Dr. Poppl:
As I indicated at the Kronberg meetings, I very much enjoyed
and your presentation. I have had an opportunity to
discussions
our
review your suggestions with my co-vorker, Professor Donald Shapiro.
I would like to havbean opportunity to go over our data processing
methods and discuss classification possibilities with you during your
next visit to the U. S. we are prepared to make available sets of
our data for trials in Europe; or to use the computer facilities
here for such tests as you may feel useful.

for transatlantic travel, we can
surely defray all your-expenses during the visit to our facility.
I would be grateful if you would let me know when next you plan to
While wo do not have funds

visit.

My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

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                    <text>7hSB-l22SB
May

J. Silvio, M. D.
National Institute of
Rockwell Building

10, 197h

Drug Abuse

llho Rockville Pike
Rockville, Maryland 20852
Silvio:

Dear Dr.

Enclosed is a formal report of the studies completed at
Hospital, Northport, under contract HEM h2-73-260 during the
first quarter of the year.

VA

While we have obtained the support of the local staff at the
Hospital and have a fine facility, VACO has decided to end the
DDTC funding on December 31, 197h. They have indicated they will
provide a decrease in the budget fer the second half of l97h and none
fer 1975. This support is the mainstay of our program and we cannot
sustain our effbrts without it.

VA

With the funds remaining in the contract, we can sustain the
project through the third quarter of the year, provide followuup for
some patients during the fourth quarter with an orderly termination
of personnel and transfer of patients to other treatments with the
present termination date of the contract.

Unless the present circumstances change, we will be unable
to participate in this interesting and imyortant study program beyond
the present contract period.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

max
MF:ed

Enclosure
cc:

3. Yolles, M.D., H30
8. Kieffer, M.D., KSC

D.A. Swanson, M.D., VAR
Brissendin, M.D., VAH

A.
M.

Knahner, M.D.,Dean,

HSC

�</text>
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                    <text>May

16, 197h

Miss Mary Carol Revmann
SAODAP

Place, N.W.
washington, 9.0. 20506
726 Jackson

Dear Miss Newmann:
we

would be pleased

to cooPerate in the analysis of the

records to he collected in the SAODAP LdAM~methadone compari—
son study. As I understand the problem, the principal question is
to define the efficacy and the safety of s new pleparetion, levemethsdyl, in comparison with the standard treatment, methadone.
The EEG data is suggested as an index of safety, to define the
degree of changes in EEG as a measure of brain function during
EEG

treatment.

In our studies of methadone and levomethsdyl, we observed
systematic changes in the EEG with both compounds. The changes

related to the dose of each compound, the time after adminis~
tration, and to the time intthe induction (build-us; to the opioid.
Our studies with methadone defined persistent changes during the

'vere

h—6 weeks with episodes of EEG slowing and
which
burst activity
disappeared once a maintenance-dose was
stabilized and the patient received his dosage regularly. Dosage
regularity was important, for in a few instances we Observed theta
,‘burst activity in patients on maintenance therapy (100 mg methadone)
than drug intake was irregular or some additional substances were

build~up period of

used, usually opiates.

‘

it

For this reason,
could be important that the observatwo
tions be comparable in the
groups, particularly as to the
_regularity with which the dosages are given and the number of hours
siter a dose the EEG is recorded. As is usual with Quantitative
EEG analysis, the state of alertness of the sdee
must be con»
trolled; we do so by recording each sthect at the some time of

t

�Mhry Carol Hewmann

~2-

May

16, 197h

day, with the recording made with eyes closed for h minute 20
seconds out of every five minute sample - that is, the subjects
open their eyes and answer a simple inquiry every five minutes.
we believe a 20 minute sample to be an adequate estimate
of an EEG for our purposes. The sample should be in five minute
blocs with a to second eye opening in between. The details of the
recording for our analyses are described in the enclosed memorandum.

The

initial

data reduction

may be

either by period anal~

ysis or by power spectral density analysis. We have found both
useful for drug classification work. Unless your consultants request otherwise, I would recommend period analysis primary wave and
first derivative, using 20 second epochs, and 320 sps sampling rate.
We would analyse one load pair, preferably occipital~vertex first;
and only do a second if there are questions that are left unanswered
by the first analysis. We suggest that the recording on magnetic
tape be of the occipital-vertex, anterior temporal-occipital, and
frontalwoccipital electrode leads on one side. Should there be a
question of differences in symmetry, then a pair of symmetric leads
may be

recorded and analysed.

If the

records are presented cleanly on the tape, we can
l/h real time for period analysis or real time
for power spectral density analysis.

process the data at

fer each record by period analderive standard scores by contrasting the drug
periods with the pro-drug record. If a pro—drug record is not
available, then we can contrast the drug changes with the initial
record in each'subject, should you define the first records as
equivalent for subJects beiteen groups.
Having reduced the data

ysis (or

PWRS), we

these contrasts are
or louminute averages; and the changes
in the two groups assessed by an appropriate multivariate statist—
reduced

ical

The standard scores derived from

to either

5—minute

to contrast the changes induced by methadone and leveSince no placebo group is available, the final statements
are limited to descriptions of the changes associated with each
condition; the changes in time; the identification or individuals
who are outside 2 or 3 SD from the mean of the group; and a contrast
of the levomethadyl changes with those occuring after methadone.
Should the changes be consistent with previous experience, it may
be possible for either Professor Roubicek, Dr. Vblavka, or myself to
method

methadyl.

contrast the observations with the data recorded earlier at the
studies.

NYMC

�szmw n:

hhry'Csrol

Newmenn

The

w-vuwu- um..-

-‘

.. .n- 7.. w..,..,.... ..

‘n-nmwr

~3~

w

.7...“

__,.

-w. c,

V. . ..

"I'V-‘mum‘;§~w

'

facilities at the Health Sciences

May

p. —,,.‘.-

n.

we

in.

.....,

,

on. c .,

.....

..

16, 197k

Center

at Stony

these analyses for records provided on compet—
ible tapes. This laboratory is supported in large part by grants
from the National Institute of mental Health and the National
Institute of Drug Abuse. we can, therefore, to the extent these
other funds are available, provide the analyses at reduced cost

Brook can provide

SAODAP.
The 2&amp;0 hours of EEG estimated to be recorded by
Sharon/Burch and the 150 hours by Resnick/Volavke could be re—
duced in 100 hours of machine/operator time at $1¢ui§/951-

to

we

‘f

would estimate an additional 2 weeks of operator time
IBM 370—65 machine time for the statistical ena1~

“”“"EEETIh’hours of

yses provided in this study. Should the analyses requested by the
committee be more sophisticated then re can provide, we can provide
the committee with the data in card format on Hollerith cards or
IBM compatible tape for statistical analyses elsewhere.
.

Our budget should include travel funds for two trips to
Texas by a member of the staff; and two trips to New York. The
option of whether the trip is made from New York to Texas or the
reverse must be left in our hands.

also request an allowance of $4Zﬁ5. for telephone
pend other special charges that may facilitate this proJect.
The budget estimate does not include any fees for the
investigators in my laboratory. We are under contract HEM h2—73-260
and we would use the support of that program for the remainder of
19Th to cover any time charges for the investigators in this labor—
atory. particularly myself~and Mr. Peter Irwin. Should theweproject
re~
‘proceed beyond the December 31. l97h end of that contract,
for
201/month
the
of
operation
of
1975
funds
the
at
rate
in
quest
Mr.
the
study.
Irvin
manage
to
of
the services
Budget estimates are attached, reflecting these suggestions.
Should you wish to approve such a contract. the additional funds may
be added to contract DA hPGOOS, Arthur Zeke, M.D., principal investigator, through the International Association for Psychiatric Research.
That agency is also the grantee for PHS funds fer the program "EEG
and Human Psychopharmscology", ME 2&amp;020, which provides support for
the computational equipment which is needed for the analyses de—
scribed in this memorandum.
we

V

�Mery Carol Newmann

Hey 16, l97h

-h—

I trust these

comments are helpful. We would be pre~
Irwin or another member of my staff to Texas to
staff there in the proper recording of the data for
analysis. It may be helpful for Dr. Stillman or you to visit our
laboratories to discuss the work further. we are prepared to meet
with Dr. Stillman and the investigators to design the actual recording times and sessions to maximize the data for the questions
which are to be answered by these analyses.

pared to send
work with the

tapes;

I

Mr.

am

enclosing a set of notes for recording and identifying

and a budget estimate.
Thank you

for your inquiry.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

Merd

Enclosure

�qua-m.—

wg,‘:va.y""

may 16, l97h

msry Carol Newmsnn,
Max

Fink,

M.

SAODAP

D.

Budget Estimates

for

LAAM—Msthsdono EEG

Analyses

is provided for the analysis of she
single lead pair to be collected by Shsrms/Burch;
and 150 hours EEG, single lead to be collected by Bosnick/
Vblaxka. Analysis by period analysis, l/h real time.“
hours

EEG,

This estimate

Primary Reduction
390 hours

I l/h

x $1h.50/hr

$

1,h00.00

Artefact control

(100 hr x $5/hr)

500.00

Data compression

200.00

Statistical Processing

1—]:

.d'n'r—

"r

Operator time
(2 wk 0 $250/sk)
Computer time

(370/65 s $2oo/hr x

Summary Reports

500.00

hr)

h

800.00

(1 wk)

Travsl

250.00
.

1,000.00

Incidental Costs (tsl.,postags)

250.00

2

arr-r1?!”

After 1/1/75. Personnel costs
20%

x $1,h00/msn

. $280/msh a

8,220.00
IAPR

Overboad Zhﬂ

7.:

a

v'ﬁmnhr

Var-159149:

20.00

“Should power spectral density analysis be
requested, change estimate to a real time
analysis by multiplying primary reduction
cost by h.

.00
$10,193.00
1

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                    <text>May

16,

1971;

Leo Lange, M.D., M.R.C.P.

Central Middlesex Hospital
Park Royal
London

NW

England,

10

YRS

Dear Leo,

are prepared to work with Mrs. Rosselson early
regret. however, that you will not be visiting the
had
I
hoped to have the opportunity to go over our
for
States.
and
for
my
staff to meet you.
program,
in June. I

we

do

Please instruct Mrs. Rosselson to call me from
arrival. The various numbers are below.
I will suggest that she take a Long Island Limousine to the
community where I am at the time she calls-- either my home
in Great Neck, or the University at Stony Brook. We will make
the arrangements from there.
Kennedy Airport on her

My

best regards.
Sincerely yours,
Max

Tel:

Day: 516 hhh 2hh7 (University)
Eve: 516 751 h66h (if no answerQ)
516 166 Shhh

Fink,

M.D.

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                    <text>William Cloves

Station

&amp;

Road

Sons Ltd.

Great Yarmouth

Hortblk, England
Gentlemen:

In this morning's mail, I returned the galley proofs of
the article, EEG Applications in Psychopharmacology, without checking
the figures. Later today, I received the proof of the figures and in
checking these, faund two additional corrections on pages 166 and 168.
On

page 166, the formula should have a

label,

GPA~111h.

first figure

does not have a label and
In addition, a line should connect the
"6303 with the Junction of the three points under the letter
first
"0" in th§ center of the figure (see xerox attached).
On page 168, the
should be marked, MK 2&amp;0.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

M3:

Merd
Enclosure

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                    <text>May

\

21, lQTh

-v.mvr-r-

:rmzrv

Wrr.(_5‘r

v.4.

Robert Marc Hodges,
3720 Eampton Road

A

M.

Pasadena, California

D.

91107

1N&gt;Q&lt;V

I!"
J,‘

Dear Dr. Hodges:

wv-

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jaw—u.-.“

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---.

«m

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mm

1.1

Vl—‘w

Enclosed is a reprint of one of our recent studies.
For a more detailed review of the problem, I would suggest you
get a copy of the volume, Psychobiology of Convulaive Therapy,
published by V. H. Winston and Sons earlier this year. That volume
was edited by myself, Katy, McGaugh and Williams. You may also wish
to find the 1972 issue of Saminars in Psychiatry, Vblume h, Ho. 1,
entitled, ConvulsiVe Therapy. Both will give you a better View of
the problem.

..-—,&lt;

Sincerely yours,

:.
‘

‘NW-nrvpxly.

Fink, M.D.
Professor of Psychiatry
Max

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Enclosure

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                  <elementText elementTextId="106889">
                    <text>May

Prof. Dr. T. Vbssenaer

Scientific Development
1‘;

. V.

Organon

Oss , Holland

28,

1971;

Group
.

Dear Jack,

I received your letter of May 17 as I was leaving for the
in Florida and was able to carry through on some of
while I was there.
suggestions
your
In going ower the GB-Qh data in Des, I became concerned with
two questions: the range of the differences in the date from each ine
differences in washout period, use of other drugs,
vestigator (i.
rate of dose increase); and the manner of handling the data reduction
(1 missing data, symptom scores vs. global scores, equivalence of
populations in the two samples). While the data may be in better 'shape'
than presented to me, and the processing may be quite satisfactory, but
I expressed my anxiety to Honk since so much (for Organon and for EEG
research) hangs on the analyses.

ECDEU’meetings

e.,

e.,

In answering your questions, I propose you allow two steps
in getting the answer: a preliminary review of a sample of the data
by the Biometric Laboratory in Washington, and a.more detailed review
soon thereafter by yourself and Mr. Stulemeijer with either a larger
sample or the total available data. The preliminary review will permit
Drs. Bonato and Guy to become acquainted.with the details of the study,.
and to relate the design and the problems to other studies that they
may

have analyzed.

If these steps are acceptable, I suggest that one set of
data sheets from one investigator be sent to no, as a sample of the
data. In addition, it would be helpful if we could have an estimate
of the total data available in a form similar to the outline attached.
I will send these to Drs. Bonato and Guy, and will plan to meet with
then to go over the prdblens and possibilities for analysis.
Based on these reviews, I will call or cable you defining their
suggestions and outlining the times available to them. I beliehe you

should review the data processing in their laboratory, not only fer its
statistical sophistication but for their experience in handling diverse

�2'

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page 2

date from diverse pepuletion annual“.

If these

suggestions are egreeeble, I am able to cooperate
any time up to July 20 when I plan to leave for Europe to attend the
meetings in Utrecht.

I thank you for your cements about. Dr. Dolce, end I agree
with your decision. I look forward to meeting Dr. Grosveld; hopefully
we can meet in late July in 033 or Utrecht.
I am enclosing a. com! 01’ e note to Heal: regarding the
ECDEU meetings, and w visit to Joyce Smell
swung her exper»
'

ienee with car-63 end caugh.

My but regards. I look forward
United Stetes in Jme or eerily July.

to

welcoming you in the

$1110.“er your: ,

Fink, M.D.
m
Professor of Psychietry

.1

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                  <elementText elementTextId="106888">
                    <text>W”—.I&lt;'

.-p~—

on

v

winwr/n‘rl

w"..-

May

28, 197k

Rhea Dorﬁbueh, Ph.D.
225

New

East 63rd Street
York, 3. Y. 10021

Dear Rhea:

I am enclosing a copy of the memoranda which I shared
with you and Castes. I think we ought to assume responsibility
for making up these various reports. Should you wish to work on
it with me, plan to come out here next week.
Peter has written the programs for the analysis of

Variance and

article

is testing

When

on

them today.

here,I forgot to give you the enclosed
are coming, and if you are
like to arrange a meeting with Dr. Krikorian.

you were

CHAT.

When

you know you

interested, I would
I have written a

summary of the data on the effects of
on memory. It has to be edited once again, but I will send you
a copy by the end of the veek.

ACTH

my

best regards.
Sincerely yours,
Fink, M. 9.,
Professor of Psychiatry

Max

MF:ed

Enclosures

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                    <text>May

28, 197h

Richard Shader, M. D.
Director of Peychopharmacology
Massachusetts Mental Health Center
9h Fenwood Road

Boston, Mass.
Dear Dick:

It was kind of you to spend time with us at Key
Biscayne. Both Peter and I enjoyed your discussion very much
and we left encouraged that blood level and EEG co—relations
were worth the effort.
it be
make

to collect some EEG, we
our facilities available to provide you with
will be glad to
analysis. Perhaps the meeting of the Society of Biological
Psychiatry in Boston next month may provide an opportunity for
us to discuss this further.
Should

Again,

my

possible for

you

thanks.
Sincerely yours,

r-v

aw»

”1.,

-num-»-~..-“awn”,

Fir-yr

K'w-wprv

~

-

mv-r

r-r

Fink, M. D.
Professor of Psychiatry

Mb:

mun—w.”

HF:ed

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                    <text>p.

my

May

28, l97h

Gordon Barclay, Ph.D.
Director of Research

.

Department of Mental Hygiene
Albany, New York

,

Dear Dr. Barclay:
At a recent meeting of the
Jonathan 0. Cole brought the problems

investigators, Dr.
that are increasingly
facing researchers in various States of the nation to our attention.
He indicated that each Itate was frequently changing the laws and
suggested we contact the agencies in our itate to Obtain the latest
information regarding the laws now extant.
ECDEU

I have been carrying our research in human subjects in
various institutions of the State for many years, lately, at the
V. A. Hospital in Horthport, on the campus at Stony Brook, and soon
at the Central Islip State Hospital. I would appreciate references
to the laws applicable to studies in human subjects, including
patients who are mentally ill and normal volunteers. we study such
special problems as the eValuation of new treatments (including
drugs and convulsive therapy), and use controlled substances (can»
nabis and opiates)..

.—

-,.
.y

ma...“

»(

33w,“

Is there a codification of the laws applicable to these
research problems? Is it possible to obtain copies through your
office, or can you refer me to another that may make the documents
available?

.
,,._,

Many

thanks.

,.,m.......,.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

°

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                    <text>May

Riezen,

Honk van

Scientific

30, lQTh

D.

M.

Development Group

H.V Organon
Oso , Holland

Dear Bank:

First, let

me

apologize for not having reported earlier;

two weeka ago, I was concerned that my
impressions may have been in error, and knowing that she would be

but, after visiting Joyce
at the

her.

meetings. I waited to confirm.my observations with
Following are some notes concerning our projects.
ECDEU

chewed me

is directly involved with these studies.‘ Their optia
in studies of OI~63 was in marked contrast to their pessimism

Milstein

mism

with

1. Jozpe Small. I visited Indianapolis on may 7. Joyce
through the laboratories and we were accompanied by Victor

who

GB~9h.

They have completed nine subjects in
the series, and in no instance have they been able to avoid ECT.
While none of the patients exhibited a clinical.woraening, none im»
proved sufficiently to provide any feeling of optimism. When I enquired about side effects, she called her nurse—monitor who seemed
comforteble with the drug and unable to identify symptoms that were
problems to the patients. There were no "anticholincrgie" symptoms.
But Joyce's questions were sharp and her statements stronger than
the date seemed to warrant. I become concerned that we may be
seeing the development of e halo effect, i.e., the failure of the
first few patienta to improve markedly has set the etege for a
negative evaluation. She asked me whether she could discontinue
the study after ten subjects without 'breaking her worn’ to you.
(In discuseing this in Florida, she was more negative than the date
considering the very severe test to'which the drug was
warranted,
put .

a.

‘-

I'

wwwmm.w«nnnz

'v’.

s
‘2.

m

rang:

I]

r

03—

h:

�Hank van Riezen

May

—2—

30, 197h

I suggested she complete ten subjects, summarize
her observations, send the reports to you (me), and not induct
any new patients into this study until these data have been
digested.

b. OI~6§: This study is progressing well. Enclosed
sheet
data
summarizing her observations in nine subjects to the
is a
end of April. She finds 01-63 to have little effect in the immediate post-seizure recall period, but may improve recall at twenty—
four hours. She is anxious to go to the next groupof subjects, in
the same design, but at the higher dosage of 30 mg. I found this
suggestion reasonable, and encouraged her to proceed.
She and Dr. Milstein indicated that they were also
re-assessing the memory tests and they seemed pleased that some of
the methods they have developed had shown differences in OI~63
effects. Some additional tasks are being tested at the same time

as these studies are in progress.

Both she and Dr. Milstein were somewhat depressed,
however, about their local funding and space problems, reporting
that some of their grantgs had not been approved, and that she was

anxious to-obtain additional industry support for studies.

Joyce has collected tapes of EEG data with 01-63 and
is a unique 8—channel, l/h inch, General
Precision instrument which is no longer made. _Failing to find one
in New York, I decided to send a member of my staff (Peter Irwin)
GB-Qh.

Her tape recorder

with one of my h—channel recorders to Indianapolis to transcribe the
data from her tapes to mine; and we will then analyse the data here
(unless you prefer to use these tapes to test your system in 035?).
;I have set a date for June lB-lh for the transcription.

,,
w.

..

1-,_.-.,

am

.v:.

“View”:

‘qzvrr-rzn

)

-—-:

rm-zwsaﬁr'nn

Lyman-or

.1

14"‘A—W1n-mvimnjwy‘”

I

have had

(Joyce gave

a

little visitor's

and send them

to

packet of her programs;
for your.information.)

you

the presenwell received.
'(Please edit it
of the report is
and I would be grateful for any corrections of fact or-nuance that
you may suggest.) The diacussion was started by Joyce, who reported that she completed nine subjects in the ECT paradigm; that
there was improved recall of learned material twentybfour hours
2.

ECDEU:
The meeting was well attended,
ACTH Peptides on Memory and Brain
A copy
enclosed.

l,tation "Effects of
5

me

these copied

and

Function" was

�Hank van Riezen

«3~

May

30, l97h

after the seizure;

and that the effects were not evident in the
immediate post—seizure recall. She was encouraged by the find~
ings, and said she was extending the sample at a higher dose of
30 mg. Others enquired about the similarity of 01—63 to UCB

(prracetam) and to Unger's

compound

availability of the materials.

(scotophobin), and to the

timely because the next afternoon was
in depression and schizophrenia. The
N
data was sparse, with the usual of four to ten in each study.
Hoeehst was well represented (six visitors) and Dr. Alan Gordon
summarized the findings of European studies as equivocal or nega—
tive in depression. He reported sleep EEG studies, which failed
to show an effect of TRF. Drs. Prange, Lipton, Hollister and
Huey individually reported small studies without consistent findings in depressed and schizophrenic patients. Yet, each reporter
apologized for the paucity of the results; described some anecdotal,
single cases that were remarkable; and suggested that some findings
were there, although they did not know how to extract them. Itil
presented EEG and the clinical data from Turkey, and his report
was optimistic and constructive. He reported well defined EEG
changes, similar to dextroamphetamine, with clinical effects in
depressed patients of short duration, with self reports more
positive than observer ratings. There was some criticism of his
report, notably the question by Gordon that since he could not
find EEG effects of TRF in the sleep record, how did Itil explain
his findings in the alert subject. This gave Itil an opportunity
to describe the differences in methodology, the problems with
sleep assays, and the necessity for quantitative methods.
The

presentation

devoted to reports of

was

TRF (TRH)

I was left with the impression, both by the interest of
the reporters and the audience, that the peptides were now among
us, and that much study will have to be done in the next few years
defining their activity and developing new methods of analysis. A
few investigators (N. Kline. D.F. Klein, J. Simeon, L. Hollister,
R. Shader) asked about the report and 01—63, and I will send
copies of the report to them, hoping that their interest has been
aroused.
I am sending a copy of the report to the editor of
Psychopharmacology Bulletin for her consideration for inclusion
in a ferthcoming issue.

�~h—~

Henk van Riesen

May

30. 197k

3. FDA Report and Dr. Ksstin: I have decided to send
the report I have given to the ECDEU, as well as a covering letter describing the date of the Miller and the Fink studies.
I will omit reference to the recent Kastin end Sandman reports.
Abba sent me the latest report with a covering letter that seemed
unnecessarily harsh. However, I am willing to serve in the re—
lationship with him being acutely aware of his idiosyncratic and
irritating behavior, but accepting these as necessary accompani—
ments of the program.

the

FDA

In reading Ksstin's letter to you of April 29, I found
references to a study of ? OI—63 in schizophrenic patients. I
have not heard from Kastin regarding this study. Should he wish
to file an amendment again, and to avoid the criticism that we
‘are holding him up, I am writing to him directly (enclosed).

I

Because

h.

Essman:

I read the

Essman

letter

and the two

scales.

these confusing, I called hhn,snd he explained
found
He
derived from some studies by

that the tasks were

Squire.

'esserted that the tests have had some reliability testing (two
forms) and at least two applications. It should be interesting
and if they are sensitive to memory loss
(recent and remote), then thetpplication of the tests may be

to read these reports

useful
in the

5. Klein2 D. F.: we met in Florida (although we live
some community, I tend to see him in fer-away places) and

He wished to read the reports which
basis of my peptide summary, and I gave him a duplicate
set that I had with me. I shall send him a copy of the ECDEU
report and try to meet with him in Great Neck in the next two

began a discussion of OI~63.

were the

weeks.

I

have received a

letter

from Jack regarding

the visit

U. S. for a review of the date analyses of GB~9h, and I
have made arrangements for Drs. Boneto and Guy of the Biometric

to the

Laboratory in Washington

to assist us.

I have become even more interested in the peptides since
the
summary, and I look forward to listening at Utrecht in
writing
my

best regards.
Sincerely yours,
Man

MF:ed

'Enclosures

Fink,_M. D.

Professor of Psychiatry
,

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                    <text>v..w“"‘

VIV'Wn-u-vwwm

May

Lyle Miller,

M.

Yximmiwumﬂwntmvﬁ‘w"all-'wv

:W

mm:

"'mw

D.

Eastern Pennsylvania Psychiatric Institute
Henry Avenue and Abbotteford Road
Philadelphia, Pennsylvania
Deer Lyle:

I put your letter of April 18 aside as I was trying
summarize the peptide literature for a meeting of the ECDEU.
am Inllosing a copy of that summary for your information.

up,

wﬁuﬂ?'—"‘

30, 197k

to
I

outline of a study of 'ACTH h~10 and Attention'
and as soon as you have the protocol in better shape,

The proposed

is interesting

I would have little difficulty in processing it.
to the dosage. Is not 10 mg low? Why not 30 mg?

One

question is

Regarding your comment on our 01—63 date, we have
studied the changes in alertness with placebo in our subjects,
and do find that it decreases in time. For some substances,
alertness is maintained, and this is defined as a drug effect.
In the 01-63 study, we did note the change in alertness, but were
not sure that the change was sufficient to be a drug effect. We
attempted to re~exemine at higher doses, and may have ignored a
finding. since a re~examinstion shows the same changes at higher
-doses. Thanks.

I look forward to reading the protocol of the suggested
Estudy, particularly the selection of the OPT task.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

Encl.

'

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                    <text>May

.
”My

30, 197“

_—V~

cmm4v...

Abba
VA
,‘WII.’I-&lt;n-rr

rrmw

J. Kastin,

Hospital

1601 Perdido
New

M.

D.

Street

Orleans, Louisiana 701h6

It"

:4

Fr‘

Dear Abba;

uv‘VrR

Thank you

4»:

r

:n-wrrpp...

~

vr.

me-Wrywrrn

w.

rprrm-nwmmynwxnuo

w
.,

y'vjavya‘wler

r,
,.—

fer a

report, "Enhanceh-lo". It is an interestin conjunction with my

copy of the Sandman

ment of Attention in
ing study and I am.p1eaeed
Men

with

ACTH/MSH

to reed

recent review of the peptide

it

literature.

to report on my studies with 01—63 to a
recent meeting of investigators in psychopharmecology. A copy
of that report is enclosed for your information. Since I had to
write this report, I have decided to send it to the FDA as the
report they requested, and have not made any mention of the
Sandman or other data not in the press.
In your letter to Henk van Riezen of April 29, you
refer to a protocol for the study of peptides in schizophrenia.
To avoid the delays which occasioned distress with an earlier
amendment to the IRD, perhaps you would send the protocgls as
early as you can, to permit the administrative steps to be ac—
I

was asked

complished without arousing your

.

ire.

e.

Sincerely yours,

"5.5,.”

gfu

w.

Fink, M. D.
Professor of Psychiatry

Max
-«wnnctr;ruww.—tvrmw~a.magrrxryyvm

MF:ed

11.7229”.

7n~.'J:..«=-w

‘
-’

b

aw".-

.-

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                    <text>May

Morris E. Chafetz.

Director
NIAAA

5600

31. 19W

M. D.

\
“

Fisher's

Lane

Rockvillc, Maryland

20852

Dear Dr. Chcfetz:

I have read the announcement of the forthcoming
Alcoholism Conference to be held June 12, and am particularly
interested in the reports and discussions by Dru. Noble and
Cicero.

Should the report by Dr. Noble on "Strategy for Re~
search on Anti—Alcohol Agents" be available for distribution, I
would be grateful to have the opportunity to read his remarka,
since we have developed some projects testing some potential
alcohol antagonists.
Thank you

for your cooperation.
Sinccrcly yours,
Fink, M. D.
Professor of Psychiatry

Max

Mcmd

�</text>
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31, 197k

J. Mendelewicz, M.D., Ph.D.
Department of Psychiatry

College of P

722 West 168

New

&amp;

S

Street

York City 10032

Dear Dr. Mendlewicz,

to assist in the launching of a new‘
Journal, Neuropoychobiology, end.wish you well in this venture.‘
I

would be pleased

During the past year, I have become interested in the
central effects of ACTH derived peptides, and have evidence that
ACTH h—lo, a peptide chein of 7 amino acids without adrenotrophic

writing
alerting effects in volunteers. I am h—lo
a report, tentatively titled, "Alerting Effects of ACTH
Peptide in Men" and could submit it to this new Journal by the

activity,

end

does have

of July.

The authors are Max Fink, M.D. and

Thank you

Peter Irwin, I.A.

for your kind invitation.
Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>May

31.

1971;

Alice A. Leeds, M. D.
Chief, International Rafaranea Center
rbr Information an Psychotropic Drugs
Paychopharmaeology Research Branch

National Inatltuto of Mental Koalth
5600 Fiahara Lana
Rockvilla, Maryland 20852
Dear Alice:

‘
.

When I completed the presentation of ”Etfacta of ACTH
Peptidas on Memory and Brain Function", at the ECDEU Meetings,
the discussion was quite enthuaastic. Thu next day, the presen—
tations on TRY, another polypaptida. were also supported.

Rather than send you an abstract as you requasted tbr
PaychoPharmaeology Bulletin, I am sending tha complete paper.
would be of interest
Should yon.w1ah to publish thin, I believa

the

to the readars. If you feel

it is too

abstract of the length you roquaat.
my

it

long, I will prepare an

beat regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

max
MF:ed

Enclosure

�</text>
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                    <text>may 31, 197h

Turan

Itil,

M.

38 Godwin Lane

D.

Ladue, Missouri

6312h

Dear Turan:

Enclosed is a coPy of a report which I gave at the
Meeting. as well as the new paper from Lancet which may
interest you.

ECDEU

Should you have another copy of your

appreciate reading

it.

TRH,

I

would

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

Enclosures

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Deer Nate:

pleased to enclose a copy of the presentation at
I think the effects of the peptides
on brain function is an interesting problem.

the

ECDEU,

I

am

as you requested.

I will be pleased to receive a
available.

handbook should one be
My

copy

of your

little

best regards.
Sincerely yours,

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                    <text>May 31 . 197’;

Jovan Simeon, M. D.
Missouri Institute of Psychiatry
shoo Arsenal Street
St. Louis, Missouri 63139
Dear Javan:

I am pleased to enclose a copy of the report on the
peptides which I gave at the EﬂDEU Meeting. Should you be interested in developing such a program, I will do whatever I can

to assist.

my

best regards.
Sincerely yours,
Fink, M. D.,
Professor of Psychiatry

Max

MF:ed

Enclosure

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2

January 1974

Bi) Bear Development Company
P. 0. Box 597
Steamboat Springs, Colorado 80477
Gentlemen:

I regret that I cannot attond the Winter Conforenoo on
I wish to cancel the renorvation mod: on

Brain Rosourch.
my

behalf by the Committee.
Thank you

for your cooperation in this matter,
Sinconcly yours.

Fink, M.D.
Profoosor of Psychiatry

Max

Hr/cio

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2

John E. Overall, Ph.D.

January 1974

,

Departmont of Neurology and Psychiatry
The University of Texas Mbdical Branch
Galveston, Texas 77550
Door John:

if

Thank you for the reprints. I would be grateful, however,
you chango the address to which you send them to:

Department of Psychiatry
School of Medicine
Health Sciences Canter

State University of
Stony Brook,

New

York
York 11790.
New

at

Stony Brook

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

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Stanley F. Yollos.
m3 Fink.

January 1974

7583-00583

M.D.

MOD 9

Courses. 1973-197h

1.

Bialogicnl Psychiatry-«to lat-2nd year medical studentl.

2.

Brain and Behavior,

3.
4.

Cantar.

2

orcditu.

1

quart-r. Health Sciences

Biological Psychiatry. Residunny Training. Collaborativn

Program.

Bruin tad Bchnvior, lecturo 8.2108, "Balance in naalth

Profasoiono."

Mf/cio

�</text>
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Jannlry 1974

7483*00783

YILE
Max

Fink, M.D.

Stave Kahn

patterned in a moat satisfactory fashion during
the past 91: months. Ha ha: asaumad additional responsibilitiaa
with the departure of H13. Poiniar.
Mr. Hahn haa

Effactive January 1,

$8500/yaar.

HF/cia

1974,

his atlary

13

incraaacd to

�</text>
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                    <text>‘MH

1

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- -7. “men-.mwmnmm m!“"""‘-&gt;)&lt;w"1""'V‘l~f’""-.-‘u

,

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January 5. l97h
,
m,

.r.

M

.

Earl Ubell

WNBC—TV

New

York City

“hwy-y...“

1,...

"my."

”we.

Dear

Earl,

While in the city yesteday, I received a disturbing telephone
from a member of the WNBC news staff, Mr. Gannon (x2373). I wish
to share the contents of the call with you, as be indicated that he
was working on a special program describing the abuses of the private
practice methadone delivery system in the city. He called me because
he had heard that I had objected to Dr. Arthur Zaks going into practice,
and he wanted some information about Dr. Zaks.

call

'—

"

r

The tenor of his questions wasequite hostile; nevertheless,
I indicated that Dr. Zaks was a student of mine; that he had made
significant research contributions in the field of opiate abuse; and

that I had tried to dissuade him from providing methadone delivery,
in part because I believed the community was precipitating this
delivery before it was proven, and in part because I hated to lose
a good

researcher.

tell

Mr. Gannon was most anxious to
me that Dr. Zaks'
that he was reputed to be making a 'fortune';

were run badly;

clinics

that
seen to

ancillary services were not provided; that patients were
leave the offices in Flushing, 'drunk and weaving', etc. These
allegations were based on hearsay and on films taken from across the

street.

I suggested thag some of the problems may be inherent in
methadone, and not in the private practice delivery system. Had
he examined the

enquired of

delivery system.of the public agencies

SAODAP
?

investigations

?

Had he

of the results of their repeated surveys and

What is that ?" responded Mr. Gannon. Since I
could not believe such ignorance cuuld represent a reported in the
field for any length of time, I asked when he had begun this expose,
and he said last year. "Early or late 7" "Since the Burden hearings."
"SAODAP ?

It became clear to me that this young man was approaching
an explosive problem from an inexperienced and probably unprofessional
point of view. I suggested he talk to you, in the recollection that
your Judgement in these matters was most leavened, and in the hope
that if he were indeed an amateur on the trail of a 'story' based
on a politician's desire for instant fame, it would demean WNBC to
be used unwittingly, and would probably harm programs that neither

—.

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you nor

I

awn...“

this time.

;

VWwﬁ“wxn»hv-—-‘

may wish

war. uv-‘Ww-

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to support, but

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.

,

,

which have the public support

at

I trust that I am not overstepping the bounds of our
friendship by raising this question with you. As I indicated to
Mr. Gannon, if he has evidence of malfeasance it is his duty to
see that it is tried in the proper fore, the courts, not TV. If
he does not, perhaps he should leaven his attacks by reviews of the
history of the problem and the needs for the present programsTheand
the reasons for private systems, their need, services, etc.
record shows that alternate approaches were suggested but society
did select this approach.
In addition to suggesting he talk to you, I invited Mr.
Gannon to call Dr. Zaks directly. I must also tell you that I
that
called Br. Zaks and suggested that when/if Mr. Gannon calls,
WNBC
the
of
he meet with him only if a senior representative
News staff were present—- someone like yourself or someone sent by

U‘y'v‘rr,~="f'

you.

p"."'v&lt;...~a

TV. I do hope you are enjoying your
much
as you seemed to enjoy reporting the news.
as

I miss your reports on

,

present position

Pw'best wishes for a healthy and a happy l97h.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

i.
f:

E

,3:

v
van.“

ﬁ”‘.'7ﬁ7ﬁw¢ﬂﬂ‘?‘f'mﬂﬁw'

'::-x

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                    <text>V‘w‘ v,— s ,

.m

~zr

w

I

.

WWW.__.W—v

7-“...

lmr’v‘mﬁm‘m

k
wr

mm‘rrwwu'

warm-rum"

2-

«NW

m

A

~'

w

wan

Z‘vamm.mmvw

‘42-”,m‘wwv4u‘w'swwA-W

January 6, l9$h
Dr. Moyra Williams
United Cambridge Hospitals
Cambridge, England
Dear Moyra,
7.7

I”

mum-u

w

mam-mnwn

,
-

It

has taken longer than I liked to complete the manuascripts

to have them copied for your use. The ones you requested are
enclosed. The volume is in the hnads of the printer and should be
out in a few months, by April I am told.
and

awr-

r-

‘mpw

arm-cum

hhd hoped to have the summaries printed in the
it seemed too long for them and too much work for one
of us to summarize the discussions in a more concise form. I remember
the meeting fondly and hope that someone will do
again in the next few
We

Archives but

it

years.

Good

luck in the work you are doing.

My

best regards.

Sincerely yours,

Max

Fink,

M.D.

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                    <text>7483~00883

7

Mrs. clan
Grune and
111 Fifth
ﬂaw York,

January

1976

Gould

Scratton

Avcnnc
New York 10003

Dear Mrs. Gould:

I receivad an

attic.

copy of Currant Puzthe correct cover but
contained material from a book on gastroentarology. I roturuad
the volume, as rnquantod.
Bonn time ago

chiatric Thoragz,
I

would

Volumo 13. whiah had

appreciatc a taplnccmnnt offica

copy

for Volun: 13.

Sinatraly yours.
“8‘ Pink, Md)
ProfcI-or at Payehiatry
0

MP/cis

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                    <text>7688-01083
7

Scott Briar,

January 1974

Deon

Choirperoon, Search Committoo
Alcoholism and Drug Abnoo Inoriruto

Univoroity of Whohington
School of Sociol work

1.3. 62nd Streot
Scuttle. Hashinston 98105

1&amp;1?

Dear Dean Brior:
Of my atrocious: who have worked in tho field of drug
ebuoo, I con roooumond two who may be qualified for the position of Director of rho Alcoholism end Drug Abuse Institute.

Richard Roonick, M.D.. now director of the drug obuoe research and treatment program of the Deporruooc of Psychiatry.
Now York Modicol College (5 Roe: 102a: Stroot. New York. N.Y.
10029) ooouoed roeponoibility for tho progrou on my loavins
oorly lest year. He ie a tolonted peyohiotrioe with extension
oxporioooe in trearnont of opiate dependonoo. Ho in rolotiveiy
young and adventurous, and may find on invigorion to tho Scorn
of Washington e chollooxe.
Another oedworkor. Arthur Zoke. H»D., established a pri»
vote troetneot program for mochadooo maintenance oorly in 1972.
end it has ovolvod into can of the final: program. in new York
City. He is o talented researcher with a moot pleasing por~
oonolity. He he. arch-wad the university model for thooo pout
tow yours in ordor to aurora a high income. einoo he has very
young ohildron. I do boliove, houover. that he may be interested in on ooadomic poeirion ouch at you have outliood. Bio
hou- oddreoo in as thflowor Drivo, tennfly, new Jorooy 07640.

Sincerely yours,
Max

Fink.

M.D.

Profoooor of Peychiotry

HF/oio

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                    <text>7488-00688

7

January 1974

Alan Ran-0y, M.D.
Madicnl Consultant
Cantor for Studies of

,Narcotic

and Drug Abuse

ﬂntionnl Institutn of Hinttl Hoaleh

5600 Fiuhct's Lane
nockvillc. Haryland

20852

2.:

HSM

52-73-260

Dtlt Alan:
0n Gotcha: 15 w. roquoutod parmiauion to transtar $475.00
from 0.8. Travnl to Foreign T2£VI1 to permit my attendance at
tho HBC~HAS Qualiﬁes. on Problonn of Drug Dapandonca matting.
which 1- beta; hold in Marion City, March 11-14. 1974.

I

would

apprcciatc tho contract apptovsl for thin transfer.
stuccrcly yours,

m
M. Md).
Protcnnor of Psychiatry
Mileis

�</text>
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                    <text>74AP~009AP

7

Junnnry 1974

Gerald L. Klnrnan, M.D.

Suportntandant
Erich Lindtaann anneal ﬁnalth Cancun
Govurnnnnt Cantu:
Sultan. Hasutchusatcn 02114
Dun: Garry:

I hang

gong ovur tho 11st o£“1ndiv1dunln under conﬂidarn-

tian for gloatinn to tho APPA. Thar. arc.unny nuns: about than
I know littlu; for thosa with when I an aeguaintod. I hav: a

The following aro ruceunnndnd for unabordhip:
Cnncro, Gurshon. Inglis, Mbore. Hoshnr, Quintin, Rnsniek,
Rifkin, 3nd Shophard.

fun onunnnto.

I ball-v0 that c. c. Duhlbcrg has 6106.
I an troubled by only an: nan: that I know, that of

A.

Diunacio. While
is a fin: axporinantnliut. my recon: can:nctn with his as a follow aaionciat hnvo bccn unplaanant, and
I vauld ho rcsnrvnd about ro¢ounnndtng him for nunbership in
an crannisation like tbs APPA. My rgstrvations are not very
strong. but his rigidity would anus. I. to try no clue: 0th.:1f thay at. I! Will qualified.
A1

Sincoroly yearn.

m min. 14.1).
HP/cis

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7

'

Jennery 1974

Alan Henley, M.D.
Mbdicel Consultant
Center for Studies of

Narcotic and Drug Abuse
National Institute of Mental Health
5600

Ftaher'e

Lane

Rockville, Maryland 20852
Re:

HSM

62-73—260

Deer Alan:

During the past two months we have become ewere that a nua~
methadone heve begun to request detoxifinow

her of patients

cation.

u suitable candidates {at neltrexone.

Thane men are

we

have three such candidate. for
I have delayed induction
to cycleeocine~1n the hope that neltrexone would soon he eveileble.

now

date

I

whom

grateful if you eould indicate the approximate
supplies of neltrexone will be eViilehle to this unit.

would be

when

Sincerely yours,
Fink, M.D.
Profeeeor of Psychiatry

Mex

MF/cis

�</text>
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              <elementText elementTextId="59087">
                <text>1974 </text>
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                    <text>7483-01183
7

David

W.

Harris,

January 1974

M.D.

Chief of Staff
Votcrcno Administration
Franklin Dolano Roosevelt Hospital
Mbntroco. How York 10548
Rn:

620/11

Door Dr. Barrio:

Itii.

I

on writing in support of tho apnlicction of Tutnn M.
M.D.. as a resourch psychiatrist at tho V.A. in Mantra-o.

I

havo known Dr.

Itii

ninoo 1958, when our

common

interest

offocto of psychotropic drugs brought no togcthor
incarnationcl
on
coating in Roma. I was instruacntcl in
at
him
Unitcd Statoo in 1963 at his rcccnt posithe
to
bringing
tion at the Minnouri Inititutc of Psychiatry.
in tho

BEG

Be is an outstanding roooarch ocicntint who has workod with
onthuoincn and order in dcvcloping tho whoio fiold of quantita»

tivo ole-trouncophclography and it: applications to clinical psychiotty. In tho many yccrl that on workcd coauthor, I found him
enthusiastic and innovative. no is a dolightfnl person to know
and has

friend. all over the wotlé.

I an pica-0d to :oconnond him no I research psychiatrict
to tho V.A., and I on confidant that his contributions to tho

V.A. progrcao

will be significant.

Sincorcly yours,
Fink, M.D.
Profocoor of Psychiatry

Max

MF/cio

�</text>
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                    <text>7483—01383
7

Health Raeearch Council of
Department of Health

Boon 1020
125 Worth
New

New

January 1974

York

Street

York, New York 10013
Re:

Richard Raenick, M.D.

Gentleman:

I am writing at the requaet of Dr. Richard Reanick in eupof
hie application for a career ecientiet award. I have
port
known Dr. Reenink eince hie reeidency training at Hillside Eoe«
pital in 1959-1961; and aince 1967. an a member of the Divieion
of Biological Paychiatry at the New York Medical College. In
January, 1973. on my recommendation, Dr. Reanick aeenned reeponeibility for the drug abuse reeearch program: as I left for
a new position at the State Univereity of New York at Stony Brook.
Dr. Reeniok has developed into an enthusiastic, imaginative,
investigator. Hie interest nae inetrunental in
maintaining adequate cane loads for our evaluation: of cyolaro~
cine. and in auetainins the etudiea of naltrexone under initially
and reeourcaful

difiicult conditions.

accepted the reaponeibilitiee of lead—
erehip with elacrity and an the demands of the reaearch program
increaeed. gave up hie private practice of clinical paychiatry
to devote full time to these reeeerch efforts.
He

Hie etudy programe in rapid detoxification from methadone
and the clinical pharmacology of cocaine are timely and logical

exteneiona of our present etudiee of opiate ahaee. I
to recommend him for the award he aeeko.

am

pleated

Sincerely youre,
Fink, H.D.
Profeeeor of Psychiatry

Max

MF/cie

�</text>
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  </item>
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    <fileContainer>
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                  <elementText elementTextId="103858">
                    <text>7483~014SB

10 January 1974

U. S.

Burnau

nap-trunnt of Junkie.

at Narcottan

Bangorous Drug.

and

Wishinstou, D.C. 20507
Gontlonnn:

I

hnvn ruc01v¢d your

with n label angle-ad.

luctnr rusardinz an

A3308

entry

Etfcctiwu Jnnnnry 1. 1973. I discontinund operations
transfurrod eh: rcsponnibiltty {or work
It that location radRichard
Raanick. M.D.. at tho stun rd—
in that program to
argon.

Sincorcly yours,

“.3 Fiﬂk.

Md).

Professor of Puyehintry

MF/cil

Incl.

�</text>
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                    <text>7483-01783

Stanley F. Yollss,
Max

M.D.

Fink. M.D.

Capital Equipnsnt

Tbs docunantation of rsports is an essential product of
tho taaching and rasaarch functions of tho Dapartnant. Such
docunsntation raquirss rspsatsd rsprodnction and an srror-frss
tart, particularly for statistical computational information.
The MT/ST providss tha facility for storags of tsxt, tablas.
and statistical data for rapaatad raptoduction in a variety of
formats. Instruasnts of this kind can, with an adsquats supply
of inaapsnsivs atorass tapas, provids for periodic updating of

dapartnantsl reports. A aingls instrunant can ssrvics from
6 to 15 scisntista (astinats hassd on prior sapsrisncas at two
similar psychiatric facilitiss).

Display Monitor Modal olzwgoktrogia (yard

Copy Unit 5610

Tsktronix)

Bquipnsnt now availabls to tho Dspartnant of_Psychiatry
ptovidss for data procsssinz of usurophysiological analog data
for studiss and trsatnsnt of psychiatric patisnts. Data input
laboratoriss ars sstablishad at sach clinical unit of tha Dopartnant. Tho csntral procassor has only a lino printsr as
a hard~copy output. This doss not psrnit graphic display. although programs are available. Thass two units. Display Monitor
and Hard Copy Unit. ars additions to tho available squipnsnt to
provids graphic summaries of physiological data analytsd by tbs
cantral processor for can at distant installations~~our clinical
cantata. Such units must ha nodifiad for tho central processor.
and rantal is not an scononical courss.
PDP

11-60 Contggllar

ranching functions in nsurophysiological assays in clinical
psychiatry raqnita that studsnts batons acquaintsd with controllsd
*1—

�8. P. YollssI M.D.

~2~

11

anusty

1975

sxpsrinnntation sud controlled data procsssins. Tbs PD? 11-40
allows ths systsnstic prsssntstion of stimuli sad thc rscording
of rssponsss of up to 8 concurtcnt cxpsrissnts. cithsr in patisnts or voluntssrs. This procsssor will be ussd in teaching
nsdicsl candidstss and post-doctoral csadidstcs. Tbs instrussntstion also mskss possibls thc systematic recording of acutephysiological dsta with idsntificstion of stimuli on ths rscordin: tsps, such that ststisticsl processing will be possible.

MF/cis

�</text>
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                    <text>74AP~025AP

18 January 1974

Mr.

J. 8. Jackson

Suite

31

2231 Bancroft Place, N.W.
Washing ton, D. C . 20008
Dear Mr. Jackson:
The next meeting of the Aoericen Psychoosthologicel Asso~

elation will be held to March 7 end 8 at the Sheraton Boston.
Tho subject is the evaluation of psychological therapies.
Guests are welcome

at s nominal registration fee of $5.00.
Sincerely yours.
Max

HF/cis

Fink,

M.D.

�</text>
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18 January 197A

Miss Carol Havana
8AODAP

726 Jackson

Place,

H.W.

Wanhinston, 3.0. 20506
Boar Miss Havana:

lcttnt: from Dal" indicating
on banal! of DA 428 005 (SAODAP
Coop-rativc Gltﬂienl Study of LAAM and Hichndonn~~Axthur 23kg)
at.

Enclaacd

coping of two

that tha assuranna submitted

bu: bnan aecopcud.

I trust that thus. latter. complete

this anpcet of

Dr. Zaka' study.

yob§ £110 rcgnrdina

Sincarcly yours.
HI: Fink. H.D.
MF/cis

m1.
ac:

A.

Zakl,

M.D.

�</text>
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18 January 1974

Shirlia

NINE Rm.

5600

Werner

9-101

Planet's

Lana

Rockvillo, Maryland 20852
Dear Ms. warmer:

I would like to indicate that Mr. Peter Irwin, my laboratory
supervisor. will attend tbs ECDEU mooring 1n Kny Bineaynn in May.
I unuld be grateful if you would 11:: him (at my Untvcrnity ad~
dress) a: a participant, and Iand him the reservation forms.
Thank you.

Sincurely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>7483-02783
18 January 197&amp;

George 8. O'Brian, H.D., Ph.D.
Associata Director
Scientific Division
Dopartnont of Clinical Raaaatch
Abbott Laboratorioa
16th and Sheridan Road

Rorth Chicago,

Illinois

60066

Dear Goorsc:

I ragrot that further clinical touting of Abbott

boon suspendod. As toquaatad,
naturiala on this compound.

I

on

4017&amp; has
tho
background
returning

Whoa we first began our studies of oannabia in 1968, we
had no idaa that on would find thin study an fascinating as
has Qnrnad out to be. Tho vary low toxicity of tho tattahydro~
oannabinol molecule, combined with
high dasroo of CBS pona~
an idaal nucleus for the dovolopmont of a shorttranoa. make
aoting. high—potency payohoaotivo compound. Our observations that
tolaranco development is vary slow duo of vary low dasrca anhancoa
out approoiation that tho biological activity of compounds with
this nnolaua any ha of antrcna importance in clinical psycho~
pharmacology. I hop: that the ptoxrnma at Abbott will continua,
and I look forward to an opportunity to atudy than. compounds,

it

it

it:

should they bacon: available for Phaaa I
My

testing.

boat parsonal regards,
Sincerely yours,
Pink. M.D.
Professor of Foychiatry

Max

MPIcia

BMl‘o
oc: Dr. A. S. Knlkarni
’

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                    <text>7488*02883

18

F.

January

1974

Gilbort McMahon, E.D.

Professor of Medicine
Tulane Univorsicy School of Medicine
Department of Hodicino
1430

New

Tulsa.

Avenue

Orleans, Louisiana 70112

Door Dz. McMahon:
and

I wish to thank you for your letter of information of January
look forward to seeing the volumes no they are published.
Good

oyupooium.

luck in your efforts and in the dovolopmone of your next
Sinceroly yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/oio

7

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                    <text>7483-02933
18 January 1974

Daniel

APA

X. Freedman, M.D., Chairman
Commission on Drug Abuse

University of Chicago
Department of Psychiatry
950 East 59th Street
The

Chicago,

Illinois

60637

Dear Dan:

I have read the report of the

on Drugs, as

written

by Roger.

Ad Hoc

Coordinating Committee

It is

quite clear that there are a limited number of na~
tionslly~known consultants who are called upon to respond to‘
national issues in the form of drug abuse. Because their num~
bars are few, they also are also called upon by various national
organizations. It was my understanding that the AMA Committee
on Drugs had for many years assumed the leadership in the field
but because their membership reflected nominations primarily
from them , that committee did not reflect the opinion of the
younger, progressive members of the other
developed an expertise in this area.

societies who have

proposal by Roger suggests the establishment of an APA
Council on Controlled Substances and Alcohol, with a budget in—
cluding a consultant. I concur with this reconnendetiou but
would suggest one additional step. Perhaps the APA would con.
sider the development of a National Council on Controlled Suh—
stsnces and Alcohol to represent the point of view of the APA,
ACNP, Society of Biological Psychiatry, NRC—HAS Committee, Ameri—
can Psychopathological Association, and such other similar agen~
ties of which you are a leading member. Should many of these
organizations be brought together and should their treasuries be
tapped (expecially the ACE? and APA), then one can envisage sup~
port of an active office in Washington to represent the various
views of these organizations on drug problems.
The

At the least, I am writing to concur with the recommendation
of a council and a consultant for the APA.

Sincerely yours.
Pink, M.D.
Professor of P sy-chiatry

Max

MF/cis

cc: Roger E. Meyer,

M.D.

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                    <text>7483-02683
18 January 1974

Dr. J. Silvio
Clinical Drug Studies Section

National Institute on Drug Abuao
National Institute of Montal Health
5600

Fichct'o

Lana

Rockvillo. Maryland 20852
Door Dr.

no.i

silvio:

HSM

42—73*260

wish to report that during tho quarto: October 1 to
In averaged 19 patients each month to tho
about
drug
trontnant facility at tho Notthport VAR. The majority
adminniono
tho
of
unto multip1o~drug abuoorn, including abuse of
wu

Docombor 31, 1973.

alcohol.

In the third wook of Novunbor. tho fit-t patients word in—
ductod into tho lovomothadylwnnthadonc cooperative study, and
on Dacoubcr 31, nine pationto wort inducted into the study. No
difﬁtlultico or aid. offsets have been oboctvod, and acceptance
of this ttoatnont rcginon has boon good.
During Doccubot on dotoxifiod thtco patients in anticipa~

tion thnt ooltrczono would to availohlc. Supplies not being
availablc, those pationto have boon roinductod into methadone

maintcnnnoo.
two

Staffing tannins unchanged, and on are activoly recruiting
additional counselor: for tho expanding outpaticnt part of

tho program.

Attached

is a table dcactihing the caucus for this quarter.
Sincotcly yours,
Fink, H.D.
Profcuaor of Psychiatry

Max

MF/cis

Att.
cc:

D. R.

Charlton

�</text>
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                    <text>7483-02483
18 January 1976

Frank

M.

Berger,

M.D.

680 Madison Avenue
New York, New York 10021
Dear Frank:

I am pleased to send you a copy of the report on cyclazo~
cine as an antidepreaaaat and a few other reprints related to
the EEG profile mothod--a method which permits us to anticipate
the clinical application of putativo psychoactive drugs.
I understand that you have left the formal, quiet halls of
industry to enter the more bustling fields of consulting.
My

best regards,
Sincerely yours.
Fink, M.D.
Profaeaor of Psychiatry

Max

MF/cia

Encls.

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                    <text>7483-03083

18 January 1974

Beckman—New

Dimensions

2500 Harbor Boulevard

Fullerton, California

92634

Gentlemen:
have received the announcement of the New Dimensions
audio—vioual technical programs. We are interested
of
series
EEG—l,
"Electronics for EEG Technicians."
in
we

appreciate the opportunity to review this series
prior to entering our purchase order. Should it be possible,
please have your representative call me at the University.
we

would

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>7433-03683
21 January 1974

Graduate School Admissions
Box 1504A, Yale Station
New

Haven, Connecticut 06520

Gentlemen:

Re:

Steve Kahn

I am pleased to submit the following information regarding
association with Mr. Steve Kahn, who is applying for adnis—
aion to your graduate school to continue his studies in psychology.
I have known Mr. Kahn for over a year, first in his role as a
volunteer in our study programs and, since July 1, 1973, as a
research assistant. While a student at this university, he volun-

my

teered to participate in neurophysiological and behavioral experi—
in this laboratory. we found him a cooperative, bright, and
reliable participant, and when we sought an additional research
assistant, we accepted his application.

ments

Since July he has learned to record EEG and to obtain behavioral date from our ongoing experiments, in which volunteers
receive psychoactive drugs and are observed for periods up to
four hours following such administration. In addition, he has
operated the IBM 1800 computer system, including the EEG data
reduction and statistical analysis. He has carried out multi~

variate statistics

and

interpreted the results

up to

writing

a completely documented report. At the and of six months of
tutelage, I was pleased to recommend him for a promotion and

raise.

Mr. Kshn

is

an

intelligent, dependable,

and cooperative young

accepts responsibility well. I believe he is qualified
for graduate study in psychology, and he has demonstrated his in~
terast by his work in this laboratory. I recommend him for the
program which he has applied for without reservation.

man who

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>7483—03783
22

January 1974

Joli Yarvura-Tobias
North Nassau Mental Health Cancer
1691 Northern Boulavard
Manhassot, New York 11030
Dr.

Dear Dr. Yarvura~Tobiasz

I would like to propose a symposium at tho forthcoming
World Congress of Biological Psychiatry on the subject of
Quantitativa Elaccroanccphalography
Psychophsrmacology.

I

would proposa to

intita participants

who

and

sra contriﬁuting to

our nndarstanding of the offsets of biological therapies (drugs
and induced convulsions) on brain function in man, using conputar analytic methods for tho naasnrnmant of CNS changes. ﬁnch
progress has been made in tho analysis of testing 836. focusaing
on froquancy and anplituda changas; on potentials avokad by san~

sory stimuli

of

CARP);

and by

anticipatory sat (CHV). Tho number
and I would suggest sons of

potential contributors is largo

the following ha invited:
M.

Saito

Osaka, Japan

J. Roubicak

Basel, Switzerland

D. Rosadini

Genoa,

T. 1:11

Istanbul, Turkey,

H. Mstousck

G8tsbor3, Swsdcn
Darmstadt, Germany

G. Dolca

L. Goldstain
C. Shagasa

J. Volsvka

Italy
and New York City

Jersey
Philadalphia, Pennsylvania
Rutgers,

Raw

-1-

York

Haw

City.

�Dr.

J. iggvurnvrobion

‘

22 January 1974

~2-

symposiua o! throo hours would allow the actcndaon to obtain an overview of tho progress in this field. which has been
grant during tho past few years, particularly in defining drug
A

affaots. nonnatioa bioavailability of psyohoactivc drugs.
defining the lototalixcd affect: of induced convulsions.

and

I trust this symposium could be iniéndad in tho program.
Should it b. tangible. I would proposo to call on Professors

Roubicek and 1:11 to

the ncaaion.

that. tho responsibility for organising
Sincerely yours.
Fink. M.D.
Professor of Ptychiotry

Max

HF/ois

cc: T. 1:11. H.D.

J. Roubiook,

M.D.
C. Shannon, H.D.

�</text>
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                    <text>7433~06083
24

January

1974

Hard Pigmen. Ph.D.
Chairman, Tenure Committee
New York Hedicel College

Graeolsnds Hospital

Valhalla,

New

York 10595

Dear Dr. Pigeon:

I an writing in support of the appointment of Torso

M.D.. es Professor

Medical College.

in the Department of Psychiatry of

M.

New

Itil,

York

I have known Dr. ltil since 1958, when our common interest
in the EEG effects of psychotropic drugs brought us together
at an international meeting in Rome. I wen instrumental in
bringing him to the United States in 1963 at his recent position at the Missouri Institute of Psychiatry.
He is an outstanding research scientist who has worked with
enthusiasm and order in developing the whole field of quantita»
tive electroencephalography and its applications to clinical peychietry. In the many years that we worked together, I found bin
enthusiastic and innovative. He is a delightful person to know
and has friends all over the world.
New

I an pleased to recon-end his appointment as Profeeeor at
I so confident that his contributions

York Medical College, and

to the Department of Psychiatry will be significant.
Sincerely yours.

Pink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>751-0381
24

January 1974

Br. Staphan Saara
Rational Inatitota on Drug Ahuao
Rational Inatituta of Mantal Baalth
5600 Fiahar’a Lana

Rotkvillo,

Maryland 20852

Ra:

Daar Dr. Saara:

33H 42~70-98

I an plaaaad to tranaait tha auunary reports of tho study,
ggrogic gaghiag Uaarg in Greaoa (HEM 42—70-98). Na have aut—
aaritad all tha obaarvatioaa of tha thraa yaara of this affort
and submit thaaa as wall as oopiaa of tho data upon which the
summary is baaad. The 1d volunaa of tha appoadioaa inoluda:

distribution;
(2) control population distribution;
(1) population

(3) summary of acuto aduioiatratiOn Tﬂc,

hashiah, and marijuana

statistical analyaoa.

(6)

Tho auunary and

Haw

York and

trials;

tha data voluaaa rapraaant both work dona in

in Athana.

In tha aunuar of 1973 wa undartook tho withdrawal studios.
Sixtaan aubjacta want through the prooaduraa and tho data are
now in avaluation-tha EEG tapaa are in analyaia in How York,
tho bahavioral and psychological data in Athaaa.
Tha aobuiaaion of thaaa

raporta couplataa the

work under

h2-70~98, aa raqoaatad up to Jana, 1973, arcapting
Contract
tha withdrawal data. It was humanly impoaaibla to complete the
data oollactioa of a withdrawal study, aa wall aa tho analyais
of thin complex aatarial, to aunaariaa tha findinsa as wall as
complatins tho raporta of tho othar parts of tha study program
prior to the propoaad taraination data of Datambar 31, 1973.
In aubmittins the material today, wa boliava ua hava complied
with tho contract to the boat of our afforta.
HEM

Excopt

Copanhagan in
praaantation or publication of tha data

for a nathodological praaantation in

1972. an hava withheld

of thia study.

In diacuaaiona with Professor Stefania in October.
would ba 'taaantad and publiahad

to agraad that three raporta
during 1974:

�Dr. Stephen Sgsrs

~2*

24

January 1974

(l) Psychological Effects of Chronic

Beshish Use-Anoricen Psychiatric

Association,
(2)

Effects of Cannabis
Preparations in Chronic Esshish UsersJournal of the American Medical AssoEEG

and Heart Rots

ciation;

(3)

May, 1974;

EEG
EEG

and

Effects of Chronic Hoshish UsenJournal.

Because the materiel is extensive end findings on clesr,
they warrant extensive explication with supporting evidence.
Professors Stefanie, Freedman, end I hove agreed to formulate
this in e volume which we believe can be prepared by nidosunnor

end published

I had

in

1975.

that either Professor Stefanie or one of his
join us in the analytical phases in December end
Jennery, but this hes been impossible because of their teething

staff

would

hoped

loads. The reports have been completed using mail service.
After the encumbrances of funds ere cleared on Jennery 31,
there will remain an unexpended amount of approximately $4,000.
Professor Freedman, as President of the Amoricsn Psychiatric
Association, was able to arrange for the presentation of the
psychiatric date at that meeting in Hey. We would like to invite Professor Stefanie to do so.

request on extension without additional funding to May 31,
1974. to complete the data analyses of the withdrawal study, to
we

allow Professor Stefania to present some findings at the
and to work with us in the formulation of s volume.

APA.

letter is an offer by the contractor to extend the
contract without additional funds, for these purposes.
This

On

behalf of the International Associstion for Psychiatric

Research, Inc., Professor Freedman and his coworkers at the New
York medical College, and Professor Stefanie and his coworkers
at the University of Athens. I wish to express our gratitude for

�Dr. Staphan

Star;

26

~2~

January 1974

the faith and support which you and your asaociatou have had
its inception in Juno, 1970. The data
of this program have boon moot intctasting and in believo will
make an important contribution to tho complex litaraturo of can~
nabis nan. But abate the facts, no believe w. have demonstrated
that ctoos~cultura1 roaoaroh is foasiblc and doopitc physical
distances, cultural difforancea, and longuago barriors, acionr
tints of good faith can accomplish conplcx missions. Hi trust
that your flith in this program is rewarded by the data horoby

in this ptogram since

831381€9.06 0

Sinceroly yours,
Max

MF/cio

Encl.

Fink,

M.D.

�</text>
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    <fileContainer>
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                    <text>761-0391

2‘ January 1974
Coatee Stefanie, M.D.

Protector of Peychiatry

University of Athena School of Hadicine
Eginition Hospital
74,

Vaaoillisaia Sophia

Athena.

Avenue

GREECE

Dear Contae:

I have tried to reach you on a number of occasions and have
failed, eo I on writing to give you a progress report.
The withdrawal data are now in the stepwise linear regression
analysis phaoa. As Aria Linton will tell you, the more relationfind. the more additional analyses
These are progressing, and I ehould be able
of the obaervationo in about two weeks. So
to attract effects that could be related to
ships

we

of haehioh use.
Beoauee

seen to be noceaoery.
to send you a summary
far, on are not able
the discontinuation

I have been required to submit a final report to the

contracting agency by January 31, I have submitted a summary of
the data that we have had on hand up to tho fall of 1973. I am
enclooins a copy of my covering letter and, separately, I have
nailed the summaries that we submitted to fulfill tho contract
requiremente. The aunaariea do not bind you or no in any way
with regard to future amendnont, publication, or presentation.
These reports are not public and are not considered publications.
although the NIDA staff may summarize our findings in their raw
ports to Congroea. When your summaries are completed and integrated with tho findings of the withdrawal atudy, we may submit
an amanded final report to mini. The publication of a volume
describing our oxperioncao would be a more fitting culmination
of those effortl.

I have requested another extonaion in time to provido you
with fuodo to visit the United States. I do not know what action
Dr. Snare may take. but I will write an soon as I know.
Ho

have revised your auggeotiona regarding publication

and presentation of this material. I not with Professor Freedman
and he called the Program Chairman of the American Psychiatric

Association.

A

preocntation, provisionally entitled "Chronic

Haehiah Doe and mental Disorder."
.

-1.

will be

on the program.

�Because an abstract was required immediately, I wrote one. A
copy is enclosed. You will note that the conclusions are vague,
and this will allow you to write what you believe to be true
as the data unfold within the next few weeks. Should you dieagree with the list of authors or the sense of the summary. I
would be grateful if you would amend this immediately and send
back to me by express.

it

we agree with the two other suggestions for presentation
in your letter of January 3. I have asked Drs. Dornbush and
Volavka to summarise the quantitative EEG and heart rate changes
for a report directed to the Journal of the American Mhdical As~
satiation. As soon as this is prepared, I will send it on for
your approval. I assume that the EEG findings will be written
by Tom and that we will have a chance to see a draft. A paper
on tolerance to cannabis should indeed be prepared, but the data
of the withdrawal study is important for this report, and until
these data are digested, this report be delayed. The study of
psychophysiological correlates of cannabis should be written,
probably by Aria Liskos, and we would be pleased to assist in

any way

that

we

can.

To close the books as of January 31, please submit state~
cents for the balance of the funds which have been allocated
for the subcontract. I would hope that you have expanded all
the money by January 31 because we cannot carry this funding
forward. Should NIDA allow an extension in time, we are prepared to support your visit from the remaining funds allocated
to the 8.8. portion of the contract. I do not know how much will
be left, but should there be funds in addition to the amount necessary for your visit, we will nuke these available to you for
continuation of the work to the termination of the contract.

It is

a pleasure to work with you and your associates, and
on the summaries which we have dis-

I look forward to working

cussed.

.

Sincerely yours,

m Fink,
MF/cis

Encls.

MOD.

.

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                    <text>7&amp;88-04283
25 January 1974

Yoshifuni Koehino,

M.D.

3-10-11 Nomechi, Kaneeewe
Iehikewe

JAPAN

Deer Dr. Koahino:

I would be pleased to have you.work with me and constern1ete you on the extensive experience which is reflected in your
professional record and liet of publications.
My laboratory was moved to a new university in January, 1973.
While we have facilities for reeearch fellowe. we lack the financiel moans to support such e fellowship at this time. Should
funds be made available from sources in Japan, which would provide
you with the funds for travel as well as a stipend. we would be
pleased to complete your application. We would require two recommendations from preceptoro known to you; hopefully, one of then
would be from the cheirman of your department. With such lettera
and assurance of support, I will be able to recommend an eppoint~
men: on e research fellow at the Reelth Sciences Center for a

period of

12 months.

Thank you very much for your inquiry,
for the success of your effort.

and

my

best wishes

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cie

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                    <text>r—._——..__er-.

..,__.

i

we.

...__......,l

,

_.__

I.

7......"_......_e,‘w

.

..

.‘ 7....n,..,..._..w ...-

...

w

7.

January 28, 197h

Prof Dr. H. Kﬁnkel
Dr. Giulisno Dolce
CHAN

3000 Hannover-Kleefeld
Germany

Dear Dre. Kﬂnkel and Dolce,

busy at work preparing the document you requested
to tell you
for the forthcoming meeting of the CEAN. I am writing
tables are
the
of
some
and
soon
as
as
text
the
have
completed
that I
I believe
be
sent
to
you.
both
will
and
the text reotyped,
prepared
5.
mid—week
February
next,
by
office
these will leave my

I

am

I trust that this slight delay will not impair the

working of the congress.

I ask that your records be changed so that future
communications be sent to my address at stony Brook, or better
yet, my private box:
May

Mex

The

address at

and messages

my

Fink,

M.D.

P.O. Box 269
Great Neck, New York 11022
U.S.A.
New
York Medical College is
the

there are delayed.

rarely used

by me

best regards.
Sincerely yours,
Fink, M.D .
Professor of Psychiatry

Max

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                    <text>“i, .‘

1.

w.—

“Wu”.-. vs.

\

,v,

un—‘WNHW, "mum-v.17...—

v.“ wavy“

r."-\‘-~»

._....‘--—..—...1w_V»..~im____ivv—w

Charlton
Contracting Officer, NIDA
5600 Fishers Lane
Rockville, Maryland 20872

Mr. D.

Re:

HSM

h2o70—98

Dear Mr. Kharlton,
we have completed the reports and delivered these with
extensive supporting documents to Dr. Steven Szara of NIDA,
completing the project portions of the contract HSM h2-70-98,
Study of Chronic Hashish Users in Greece. I am enclosing a
copy of a detailed letter reporting the status of the project
to Dr. Szara, indicating that we have been unable to complete
the data analyses of the withdrawal phase of the study within
this time limit. we are progressing with these analyses and
shall supplement our public reports with data from these analyses.

It has

been technically unfeasible for Professor Stefanie

staff during the last months of the study to
in New York. We have arranged for a major report on
the results of this study to be presented to the American Psychiatric
Association in May, and we wish Professor Stefania to make this
presentation. As we have indicated, there are allocated funds from
the contract portion of the study that remain unallocated at this
to send

one of his

work with us

time. We have requested Dr. Szara, and now ask your office, to
consider an extension of the time of the contract until May 31,
197h, without additional funds, to allow the presentation-of these
data at the APA, and such additional analyses as may be desirable to

be completed.
‘2'

SKEW'J

we;

January 28, 197h

'2’"

19:99.

,‘.

letter

an

Should

offer

this request be approvable, you
part of the Contractor.

on the

may

consider this

a
N)»

{mans-7.

.
,'

"*1€W_I_IK\€T‘P""'

”um,

may”

I wish to take this opportunity to thank you,

and your

office, and particularly Mr. R. J. Gradwell for their cooperation
in this unusual and interesting study program.
Sincerely yours,
Max

Fink,

M.D.

Executive Director

�</text>
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