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                    <text>ﬂmnv‘:u‘iww,‘

sv-

or
w

aP'D.’_'

[in

wanmhcr 20, 1975

Irving Taylor,

M.D.

Ellicott City,

Maryland

Taylor
Duar

Manor

Hospital

210h3

Irv,

I finally fbund the tin» to read the two volumes edited
by Frgnk Ayd you 30 kindxy sent ma, the one on Rational Plycho—
pharmacotherapy and the second, on the Medical, Moral Issues. I
admit I expected tha usual conference fare —~ overdcne chicken,
peas and mashed potatoes —u but was pleasantly surprised by the
variety and freshness of the subjects as developed by the partici—
pants. The insane of research subjects, right to treatment, and
legal~psychia$ric problems axe well covered, with some refreshing

insights.

I thank you again fbr the thoughtfulnoaa in your gift.
Sincerely yours.
Fink, M.D.
Protbnsor of Psychiatry

Max

MF/mr

�</text>
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                    <text>,

r,

v ”0,...

.v—w.‘

,_...,,1

.-

73..» ”1;”

.

Haw-p. ...
‘

,

-

«

-«-.z.,..-.v-m

z.‘-.-v-rma~qnu——ym'mmy”.

v .

w

-

--

nr-m

-.-,~-zw—:z—n-u

vw-w-v

a

.u-v 'WV»'-~'wxrﬂv'r2‘)~u ..

ms

war-arm ww-w.

WV...

November

Ms,

21, 1975

Jesse Halt!

1521 Sylvia Inna

East Mhadow,

New

York llSSh

,4.

«v

A

Dear Ms.

Vblff,

—

Thank you

uv—«w—

for your

Untbrtunately,

um

letter of Hovombor

hamn

18th.

discontinued our studies of

marijuana and relinquished our pormit lama tins ago.

I

mammww—vmmwvv—wr‘w&lt;mmv'w.-—,m~

do not know anyone

conducting such research

in thc matrcpolitan area

at this tin».
Regretfully.

,..na——-—r—.—.

Fink, M.D.
Professor of Psychiatry

Max

“u“.er‘

._

"n.

1,-w‘"

v

x
»

MF/mr

-

�</text>
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                    <text>\- r—rw-wwv—WWm—wr

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,

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,

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v

Novnnber

y

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1975

“mum—.7.wﬂ...__.,....mw——.—v._w,

.

Lin

Down-

Mix

Fink,

‘

M.D.

mug;

~m

Rainhnricmnnt

.

visit

M.

Kits

V

V

,

mnwwwx

rw-Irﬂrwww

Dr. E. Kht: visited us sk tbs and of the summer. When
I not him last VIOK he was edbarrassed. but asked if the reimburseaunt tbr expense: of his visit would be paid. It had not been last

ﬂack.

Wb aaruod to rciﬁbnrso his expanses.
thn
check
on
ntatus of the request!
to

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arrange

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.

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am

nmvrmum:7r

ancrtunnt of Pharmscology
_Tho‘Uh1vuraity of $.23:
Bhalth Science cantor at San Antonio
7703 Floyd Curl Drivu
San Antonio, Than: 7828h
‘

Dear Dr. Baum,
Thank youffbr

the invitation to participate in the

volunc, “Social Meaning of Drugs."
mitmnnin are too

great to «lieu

me

I rogret that my prosent cam~
to give this qnhation preper

attention.
As

an

alternate, you,m:y wish to invite Alfred

,Frecdman. M.D., of tho

New

York Mbdical 0011033.

He 13

K.

unusually

sophisticated in the issuah of tha social and clinical usas of
drugs.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

.1 :

._r..

v.“

.7

.

�</text>
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                    <text>December

2,

1975

Dir. Ken 8.101111

Dupartnont of Public Safhty
lhh - Administration Bldg.
SUE! at Show Brook, 3. Y.

Room

In:

ARA

momma,

Md).

Dear Mr. 85011.11,
The above-named

is a

member

of the

Mutant

of

Psychiatry and Behavioral Science and as such should be afforded
a parking

sticker for tha

”Y"

parking

lot.
Sinmmly your: .
Fink, M.D.
Professor of Psychiatry

Max

KF/mr

�</text>
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                    <text>December 2, 1975

Lcthar Kalinowsky,

115 E. 82nd Street
New York City

M.D.

Dear Lothar,

I read, with much interest, your note about the Congress of
Psychiatric Surgery, as published in Psychiatric was, and wondered about
the lack of interest that you cite. I wonder if the political factor you
cite is indeed as strong as suggested. I would look to ourselves, for I
find that our peers, particularly those in the Society of Biological
Psychiatry, are as smug and as disinterested in clinical issues as the
rest or the APA.V Another factor may be the lack of publicity for the
Congress, for I cannot recall seeing an invitation.
One response that may be helpful is for the secretary for the

next Congress to send announcements to the mailing lists of the former
Electroshock Research Association, EPRA, the Society of Biological
Psychiatry, and the American Psychopathological Association.

Another response, if you believe that the Society of Biological
Psychiatry, in swallowing the Electroshock, cog, and Insulin groups, should
be interested, is to act to lead that organisition along clinical lines.
I have been dissatisfied with the programs of SBP, and I discussed this
with Charles Shagass a few years ago when he was on his way up in the
Society. He seemed to listen, (with one ear) in appointing various comp
mittees last year. we did have a clinical group for the Program Committee
this last year. He also appointed a Nominating Committee of Leo Alexander,
A. Friedhoff, and T. Itil. These men, however, under the leadership of
Leo Alexander, elected chemists to the leadership
and with the aged
hands of Wortis, Himwich, Bennett, and Thompson still very much active,
there iaslittle hope for a change in the next row years. Perhaps, in your
position as a statesman of the Iociety, with Heath, Alexander, Nurnberger
as friends, you could still see that young men, with clinical interest,
are appointed to leadershipfroles, especially the Journal and the Program
Committee. Then the society could play a clinical role, as it promised to
——

play when it absorbed the clinical societies, and psychosurgery could get
a reasonable hearing.

�Lather Kalinmky,

M.D.

12/2/75

~2~

could consider the development of another notional organ~
isotion on the somatic therapies elons the lines suggested by Len Commer.
(One

This is a formidable task, and one that would be conflicted at the outset
because of the different constituencies ~~ the academicians. clinicians,
and

the hospital therapist with

little academic interest.)

Another suggestion: would you orier a panel on peyohoourgery
program? It may not be too late.

for the next meeting's

Perhaps some of these actions would serve to alert members or
our organization: to the next meeting of the Congress of Peychiotric
Surgery. At the least, perhaps this note will remind you to add my name
to the mailing list.
My

regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mex

MF/mr

P.8.

~

Your

it,
and Turkey.

on

letter

but perhaps

on

we

-

I've never been
the Orient Exprees was stimulating
could try e section in one of our trips to Greece

�</text>
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                    <text>N

wr&lt;.q-~&lt;

v,

.rv.”

«WW—m

W

December 9, 1975

:

c.

Jlf

;}

"

~

5

.

A. CObb, 14.1).

Assistant Protesnor
university of California, Davis
Department of neurological Surgery
School of Medicine
hBOl X Stroct
Saorsnonto, California 95817
Dani Dr. Cobb.

..,F

The

material.

is

on exporinontal compound
two clinics in the
(Dr.
S.
Ferris) 1nd at New York
Univorsity
Mbdical College (Dr. R. ﬂornbush). Both are foouasod on single
trials in umbulntaeyy»outpat1onts and are at loust two your:
away from multiple aone triuls.
ACTHszjg

trials in elderly patients in

now in photo 11
U. 8. ~ at How York

I regret thut the ortiole ruined premature hopes.
Thank you

for your inquiry
Binoorcly yours,
Max rink,

M.D.

Jrofbsaor of Psychiatry

�</text>
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                    <text>. -~,~..~.vr.v1\-—..,m“MW

57,...

wv'tnAs-

,;

w

:....---n

m..-

’7.

up t:.w..w;.~.wm—.'Anurw"n

r

wmnmwy,qw.m. hm.

. _,., “w..." »'v--v6‘vr-".'"."

1—5. :‘

,‘V

--

,-

v

'v

-.4~,~

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4

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vamwwu

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Decsmber 11, 1975

~qu

Dr. William Eudspeth
Division of Behswiorsl Sciences
Medical School
University of Hsvsds
Rana, Nsvsds 8950?
Bus: Dr. Budspoth,
Enclosed are two of our latest reprints. Most of the
work can bu found in the summary report.

citations fur our

If s special aspect of this work interests yau, I
will be glad to sun's: s specific inqniry.
For s mare general rcviev of the problsn you may wish
to gut tbs vnlnmn edited by Dr. Itil. tram which this chapter is
abstracted.
Thank you

for year

intsrlst.
Sincsrsly yours,

‘

ur/nr
Enos.

Fink; M.D.
Professor of Psychiatry

Mix

~r—

�</text>
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                    <text>,

w“

‘

V.

,» -.~vr :‘mv.v‘-'WF.~',

w—w—

, .,

mm

,1

,

-. v

\"u 3-

““7

u‘

any. «n—

NV-r-v.‘

.~

uw—v wan—r ww-r—r‘wrwxmw

‘v‘rww—V

“iv—T.

7..

n. kuqu. -vm~“-n

mrmmwuww 5—».qu

"V'rwvruurt-E

MM

December 11. 1975

Dr. Boston Martin

Chief, Spinal Cord Injury Service
East Orange V. A. Hospital
East Orange, N. J. 07019

martin,

Dear Dr.

The work

with

ACTH

h~10

htl

been aeueribed in exccllent
318%, 1975 by Jtan

detail in "scieneo," August 23th and August
I

Mnrx.

in

man.

eonmend

to

these artialca to you.

David da Wied but not publinhed any work on Vasopreasen
my knovladge.
I do not have a file on his animal studies.

feel thn$ there 1: an applicntion for
at the V. A.. it may be useful for you to
know thax I hold the IND for human studies and would be glad to discuss tha project with you.

ACQB

h~10

Should you

in your

work

Sincerely yourn,

Mb:

Fink,

M.D.

Protester of Psyuhistry

MF/nr

�</text>
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                    <text>4.:

6%”

“--

n
-&lt;&lt;

.-

December 11, 1975

cw!'\“"mqw

5—:

Secretary,

New

2

Committee on Admissions
York Academy of Medicine

East 103rd Street
City 10029

New York

Gentllunn,
Yolles,

I ea pleeeed to second the nunihntion 0! Stanley P.
a Fellov of the New You! Academy of Medieine.

M.D. en

I have known Dr. Yollee for more than a decade, first
in his role as Director of the Setilnel Inetitute of Rental
Heelth, end since 1972 as Cheirmea of this Department of

Psychiatry.

He is an outstanding physician. edm1nietre$0r, end e
hnneniet. I believe we would‘ve hencred to count binmuons
cur Fellows end I em pleased ta reoamnend his edniueipn. gj.

Sinceruly ydufq, ;?N?~vﬁ=

.ppi
ychietry

Fink, M.
Professor of

Mex

w;
i
I

!

MF/mr

‘

‘
&lt;A..r—w-~.

«-

.

�</text>
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uv—

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-'

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Decembeerl2, 1975

Richard I.H. weng, M.D., Ph.D.

Professor of Clinical Pharmacology
Chief, Drug Treatment Center
Veterans Administration Center
5000 West Notional Avenue
Wood

(Milwaukee), Wisconsin 53193

Dear Dr. Wing,

In the ebsence of Dr. Swanson.

South Africa,

who has

returned to

I shall try to respond to your letter to

To the best of my
LAAM-Methedone project were

Dr. Ling.

recollection, the participants in the

considered co~inveetigetore. Surely,
Dr. Swanson and I would not have volunteered our participation
bed this not been assumed in the negotiations.

your letter.
I am surprised by the posture reflected in
error, and that your
I trust that your View of the matter in inwish.
letter will achieve the clarification you
I trust the matter will be resolved amicably. With best

wishes for a happy holiday season.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MF/mr

cc/Welter Ling

.

,

�</text>
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                    <text>—-m-----—r~

warm-u-

,

’Iﬂ‘l‘er'ﬁlnyi:u

a

.

‘7

-__.... ..., “my ,,
,

”nu” , in

»,—.W,W.—mw. 7.--.

December 12, 1975

Jchn R. Bergen. Ph.D.
wcrceoter Foundation for
Exporimsntal Biolcgy
shravcbury. Hasuachunctts Olshs

Thc

Dcar John,

I am pleased to nominate Dr. George Heninger fur
aaibcrnhip in the Society for Biological Psychiatry. I have
known of his work for more than ten years and have followed
his cloctrophyniologic atudicn with intcrcst. He is a capable
investigator and has contributed much to our understanding of
tho electrophysiclcgy of psychoactive drugs.
His curriculum vitae

I

command him

is attached.

for maubcrship.
Sincerely yours,
Fink, M.D.
Frofeasor of Psychiatry
Max

MF/mr

Enc.

»

.v .

7“.er—

�</text>
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»

\
...

m

"TV—w.

'_,._..,_,,...

.A

—
-

_~.—4»

-n—l

VF'J'vng‘

Doccmber

12, 1975

George R. Honinsor. M.D.

Associste Professor of Psychiatry
School or Medicine
Department of Psychiatry

Isle University
3h Park

Row

Street

Haven, Connecticut 06519

Dear George,

I receivsd your letter or December 9 and sympathise with
the expressions. I on plcssod to rocommond you for membership in
the Society of Biological Psychiatry and will vrito a letter of reference on your behalf. You msy wish to ask C. Shagsss or T. Itil

to second the nomination.

Membership in the ACE? is more complicated. Esothellow
one nomination s your, and I have planned to nominate one
of my studonts for 1976. The nominations for 1975 are slrosdy

is sllovod

closed.

or the societies that are active, the APPA seems most
responsive and perhaps your attendance at the next meeting would
permit you to Join in the discussion of the issuos which you raise.
The Society of Biological Psychiatry is not very active in such issues.
although thore was some interact in the California regulations of
EST and leuootomy at the lsst wasting. Perhaps there will be some
activity this your in San Francisco. Abstracts are requested by
January 15 for that wasting, and should be sent to Dr. Iver Small

in Indianapolis.

The last question is difficult for no. I have no inkling of the program for the 20~yosr rovisw of the ACKP.; You may
offer your suggestion to Jerome Lavina, Burt Schiclc, Philip May,
or Al Diﬂsscio, who usually scum knovlsdgesbls about ACNP matters.

Sincerely yours,

as: Fink,

M.D.

Professor of Psychiatry

MF/mr

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                    <text>“m

mvr—w-.- Vﬂru— W.ﬂ‘mmm—w~wai'»i'wcvn—'wwu—:.—...w_..a-,. ...,.

w

,

__.

,

.

vi

_

.

.7

_.

_

. n

V

_

_

‘_

w,

‘_,,___V_, ,__,

i
December 29, 1975
Mr. Gavin Borden,

President

Garland Publishing, Inc.

ShS
New

Madison Avenue
York 10022

Dear Mr. Borden,

your

letter

I recall the flight from Houston with pleasure, and
stimulated me to retrace the conversation.

It is

simple for me to send the enclosed report, which
was put together by one of my students in June, 1969. We have since
used it as a text for resident physicians at our training center, and
.

1'7W"-&lt;1‘.

Wm'm'wmﬂ'mm-wwﬁw

on various occasions, I have distributed copies to students at other
schools, usually when I have been asked to lecture on the convulsive
is clear that some sections
therapies. In reading the volume today,
should be updated, the references augmented, but on the whole the
descriptions remain quite accurate and useful.

it

difficult, however, is to estimate the market.
experiences with the publication of a conference proceedings,
I am of the opinion that advertising is more important to the sale of
a volume than the content. An estimate of the utility of the volume
and its sales would depend more on the advertising than on the details
or their accuracy (although I could assure the reader that the text
is as accurate as possible).

Following

More

my

Should it seem feasible, the text could be updated and
revised within a few months. Perhaps you would read this text, and
if there is some interest, we could meet on one of my next trips to the

city.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_

_,

,

,_

�</text>
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                    <text>”:4

,t'vrwﬁu,""

v-

January 9. 1975
Dr. Khlkerni

Associate Director, Peychophermecolosy
Abbott Leboretories
Earth Chicago. Illinois
Dear Dr. Knlkerni,

Professor

suggested that I send you the enclosed
Itil
some of the date from our
which

represent
papers on Thoudelteu9,
studies or the cannabis derivatives.
studies in
initial
EEG

Kev York, we were interested
end
defining the significance
effects
in characterizing the
merihunne
and heshish.
THC—deltep9
of
in the response of

In our

we confirmed

these observations in occasional users

by similar studies in long term chronic hashish nears who had
clear evidence of tolerance.

we been been street by the
THC~delta~9, when looked at

In defining these patterns,

profile for
significance or the
from the vantage point of the hypotheses relating
behavioral response or drugs in men.
EEG

EEG

effects to

I truet these papers are useful.
Sincerely yours.

% ,1 4;, Amu“
a

Fiﬁ,
m
Professor of PSyehietry
,

MUD.

cc: T.

Itil

�</text>
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                    <text>0%
January 13. 1975
William E. Crisp, M.D., Chairman
Department of Obstetrics &amp; Gynecology
Maricope County General Hospital
2601 East Roosevelt,
85008

Phoenix, Arizona
Dear Dr. Crisp:

Your letter of January 3 raised a number of
questions, the answers to which are unclear. I couldinteresting
not
these from my own experience, and referred to the volume byanswer
Kalinowshy and Hippius (see page 198), and discussed these with
Lothar Kalinowsky, Richard Abrams, and Dr. Edward Sachar of the
Albert

Einstein College or Medicine.
The observation you

cite, that

hypothalamic stimulation

ovulation is true if the locus in the brain and the
electrical parameters are well defined. In EDT, seizures are
generalized, currents are large and many areas of the brain may he
affected—~1ndeed the effects may vary with the location of the
electrodes and the configuration of the skull so that effects
may
be more variable than in depth electrode studies.
may induce

we are not aware of an increased
rate of pregnancies after
Since patients who are severely depressed often complain of
interrupted menses, their appearance after successfuly treatment
is usually interpreted as a facet of their improvement.
Whether
the return of menses and the likelihood of pregnancy may follow
has not been studied.
ECT.

In menopausal women who become depressed, there may be
interruption of the menses, as with younger women. Following
treatment, these women occasionally menstruete again and it is
difficult to say whether their menses have returned after meno‘
pause or whether the depression inhibited their menses and the
lifting of the depression resulted in a continuation of the menses
an

until a later
inquiry.

menopause.

I trust these answers are of

some

use.

Thank you

for the

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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January 22, 1975
Mr. Robert L. Robinson,

Psychiatric

1700 18th

News

Street,

Editor

N. V.

weshington. D. C. 20009
Dear Robbie:

is often fun, and some newsworthy
mixed in among the edvertisenents. In the latest issue,
found some book revieve of interest. particularly the one on clonoReading the Psychiatric news

articles get
I

It is a poor volume, and I use surprised that your editorel
committee chose that eolume end have ignored the volume, ”Psychobiology of Convulsive Therapy", edited by myself, Kety, HoGeugh and
Williams, 197h, V. E. Winston and Sons. The volume was sent to the
APA for review, and has been ignored. Until I sew
your note on clonetherapy, I thought it wee a reflection of the APA's preeminent interest
in soft-heeded psychiatry. Perhaps it's a matter of squashing wheels
end grease
anyway. thought I'd squeak a bit.
therapy.

—

Regards.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Hex

erd

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7.,

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w

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\

,c

January 22. 1975_
Steven Schloasberg,

Janssen

R

&amp;

501 George

New

D,

Inc.

Street

Brunswick,

New

M. D.

Jersey

08903

Dear Stgve:

.vn

(«hi—v.7"

.Congratulations on your new position. From my know—
ledge of Paul Janssen and his teams, you will be kept busy with
interesting and novel ideas. My Bast contact with Janssen R a
was with regurd to tho central effects of an anti—helminthic
with presumed antidepressant qualities - tetramasole(?). What
did happen to it?
My

1..

best regards.

an"

Sincerely yours,

7*

.7.

lmuu"!-«1::~.'V".‘~xr

Fink, M. D.
Professor of Psychiutry

Max
-

maﬁa-"1:

..

v.»

”an-mum.

vwmrwvww‘

A

Merd

D

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6w:

:nuprnq-a'v.».a

—vs

January 2h. 1975
Frank

J.

Ayd,

International

Jr.,

M.D.

Drug Therapy Hewsletter
912 west Lake Avenue
Baltimore, Maryland 21210
Dear Frank,
»

Thank you

for your

letter

concerning your candidacy for

the APA. On two grounds, the letter distresses me - that the APA
presidency is politicized, and that someone without "training" in
the Job by prior experience st the APA would consider assuming

scientific society and it is
scientific societies to run political campaigns,
advertising, solicitation for votes, 335, I regret the change
and do not wish to participate in such activities. Nor do I
believe serious scientists ought to participate in the demeaning
displays required of politicians.
leadership.

unusual for

The

APA

used to be a

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

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                    <text>February 3. 19$5
Dr. Norman Weiner
Department of Pharmacology

University of Colorado medical Center
Denver, Colorado 80220
Dear Dr. Weiner,
'

is

I

,

2'

writingnon behalf of Miss Carolyn Poinier,
applying for a graduate award in pharmacology.
am

She was

/

first recommended to

me

who

by a fellow graduate

student, with interests in the
2’b1ologioal sciences. who/oould be useful in my study program. I
,6 met and liked her, appointed her as research aeeiatant. She Joined
3*hy staff in the summer # 1973. Our work involves the analysis of
’
the effects of psychoao ive drugs on EEG and behavior in normal
volunteers. She soon begane proficient in EEG recording, interviewing,
data analysis, and in operating our IBM 1800 analytic system. Within
a few months she nanomed responsibility for one of the studies end
2b; Colby College, as an ohtetanding

.

jcarried out with the ninimnn of supervision.
She was bright, resourceful, and dependable.

When

I

moved my leboratory ﬂron New York City to Stony Brook, she elected
to move with no, and}nade the tranhition with relative ease. I

encouraged her to select

field of graduate study and was pleased
that she would like to go on in pharmacology.
I believe eh will doiwell, foriehe is a sincere student, interested
in her work, 2end wh we were able to arouse her interest, we were
rewarded byldedicated\and enthusiastic work. I believe she is
innovativeéand will be hhle to handle a graduate program with caseshould ehe’find a topic t at interests her, I believe her work can
to exceptional. I acumen her highly and would be pleased to consider
when she announced

,her again for

my

-e

staff.

Sincerely yours,

5%

‘

2

,K

j

“.11..

.4\

;

Fink, M.D.
.Profesaor of Psychiatry
Max

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                    <text>February 6, 1975

Gordon Merjerrison,

M.

D.

Department of Psychiatry
University of Sesketchevan
Saskatoon, Saskatchewan,
Canada SYN,

(1/

0WD

‘

Deer Gordon:
1.,

drug literature,
trying to catch up on the
an interested in some of your recent articles. In the study of diezepem
and trenxene (Stat. Pbychiat. Z; 31, 1973) your note (page 35): "...there
was e definite drug effect on the left-sided EEG amplitude measure for
each drug over time, the side which characteristically yields changes
in the signal measures which relate to psychoactive drug effects.
"Again (page 36) "...the coefficient of variation (left hemisphere

I

measurement)

and

EEG

am

increased..."

Can

I

assume

Including beta spindling?

the changes were not apparent

on

the right side?

Is there any other evidence_or the aide specificity for
Any other citations I can read?

drug effects?

another mattere I am interested in your EEG studies
with drugs: may I request reprints of your studies of pimozide
(canad. Psych. Ass. J. lg; h37. 1971), Chlorprothixene (Canad.Pbych.
Aae.J. 1g: 533. 1971) and whether that may be in press.
On

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

.'

,
A”,

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                    <text>/

STATE UNIVERSITY OF NEW YORK AT STONY BROOK

€-

Health Sciences Center - School of Medicine
'
De p :1 r‘ment
of Psychiatry
t
and
Behavioral Science

Mr. Gerald

Stony Brook, N. Y. 11794
Phone: 516-444-2413

February 6, 1975

\

Piel, Editor

Scientific American, Inc.
hlS Madison Avenue
New

York, New York

Dear Mr.

U

I

’lfz/I’,,..———e'v“

w

10017

Piel,

two topics for your consideration
-—
American
the effects of seizures (con—
for reports in Scientific
vulsive therapy) on mood and behavior in man, and developments of

I should like to suggest

quantitative electroencephalography in the study of psychoactive drugs.
These topics are quite singular but there are peripheral relationships'
educa—

which makes their review complementary.
tional and social reasons.

Both are timely for

is based on the observa—
tion that repeated seizures at daily intervals elicits long—term’effects
on mood, thought processess and affects in man. It is effective in
as a treat—
allevi ting severe depression and mania, and was developedcoma
(insulin
Convulsive therapy:

This treatment

de in the 1930's, concurrent with studies of daily
coma) and leucotomy (psychosurgery). Their concurrent development has
led to some confusion that these treatments are equivalent, and the
View
same name, "shock therapy" is erroneously applied to all. Many
few
decades,
their mechanisms of action as the same. During the past and leucotomy
however, insulin coma has been replaced by drug therapy,
(psychosurgery) has found a limited niche in the treatment of a small,

ment

m

well defined group of mentally ill. Repeated seizures, in contrast,
are used more widely, and in comparison with other therapies for de-

pression, exhibit better therapeutic results.
While it is customary to say that we know little of the
.
mode of action of these therapies, the opposite is true. The neuro—
seizures
physiology of the seizure and cerebral sequellae of repeated the
induction,
seizure
the
of
The
parameters
have been defined.
on perform—
effects of different electrode placements, and the effects
known
of the
While
is
less
studied.
been
have
and
memory
ance tests
modern
the
to
much
relevant
is
that
biochemical effects, there is
‘

I

�-2biogenic amine hypotheses, and some unique studies of cholinergic
mechanisms are particularly contributory to our understanding of the
role of neurohumors in brain function. Indeed, it is fair to say that
we know as much about the biochemical aspects of seizures as we do
about antidepressants and sedatives.

basic science point of view, the ECT process contributes
to our understanding of seizures (epilepsy), the role of cerebral hemis—
pheres in behavior and particularly, memory; and such psychologic mechan—
isms as the role of personality in depression and changes in task
performance with changes in brain function.
From a

educational point of view, a presentation of the ECT
data may alleviate misconceptions about 'shock therapy' and provide
independent information to allow the reconsideration of laws restricting
seizure therapies now in force in California and under consideration
elsewhere.
From an

Some of the recent physiologic, biochemical, and psychologic
data were brought together by the NIMH in a conference, published
in mid—1971; entitled, "Psychobiology of Convulsive Therapy", edited by
myself, Seymour Kety, James McGaugh and Thomas Williams (V. H. Winston,

(memory)

Washington, 197h).

‘

z

Quantitative ElectroencephalOgraphy: The measurement
of the electrical activity of the brain has been a subject of interest for
more than four decades. During the past 15 years, the development of
2.

-

sophisticated quantification methods based on digital computer programs
and an understanding of the requirements for contrdued experimentation
has defined applications in psychopharmacology which are of general
academic interest. Psychoactive drugs, hallucinogens, and drugs of
abuse have defined effects on brain function in the alert subject. These
effects are drug specific, that is, each compound has a defined signature
which is used to classify the compound. When new compounds are assayed,
EEG classification provides a prediction of their clinical application
before

human

trials
The

are undertaken.

techniques are sufficently well developed to assess

dose response curves and to measure bioavailability and neurophysiologic
equivalence of compounds. Lately, the EEG methods have been compared

with blood level measurements to study the pharmacokinetics of drugs

affecting the brain.

Quantitative EEG has been used to develop automatic sleep
classification scoring systems. Parallel with these systems, is the de—
velopment of automatic drug classification systems.

�applied to problems outside psychoIn
pharmacology.
our understanding of the ECT process, the methods have
shown that electrode placement and hemispheric localization are contributory
to clinical effects. The methods have been used in studies of drugs of
abuse, particularly in the role of THC-delta-Q in cannabis, and in
examining the realtions between heroin and methadone and their interactions
The methods have been

with narcotic antagonists. Some students have assessed the effects of
hyponsis, zen, and transcendental meditation using these methods with
some success.
.

From an educational point of view, a discussion of quantitative
analysis would be of interest to psychopharmacologists, neurophysio—
logists, psychologists, and drug abuse specialists.
EEG

I commend both topics to your consideration. In part, this
occasioned by discussions with Dr. Alfred M. Freedman of the
New York Medical College, who has been a firm supporter of these programs
for many years. Should it be useful, I can supply the usual literature

letter is

and suggest the names of
Thank you

scientists

who

are active in both research areas.

for your consideration.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max
-

Merd

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                    <text>“
v~w~:,-,

."‘&lt;-'wru‘e'

February 6, 1985

Mr.

MoQuade,

W.

Fortune Magazine

Senior Editor

1271 Avenue of Americas
York, New York

New

Dear Mr. Mchade:

this

The

death by suicide of

Mr. Black

of United Brands earlier

it ill,

week set me to wondering whether he had been depressed;
he had
he had sought treatment; and then, to musing that even
he
would
have received the
was unlikely that
seen a psychiatrist,
treatment most effective for depression ~ convulsive therapy - because
as? the many professional and lay misconceptions of this treatment.
.

if

it

it

Among

reasons for

its.lack of use are misconceptions about mental
name, 'shock therapy' , and the bade press,
devastating article published by the New Ibrksr this

illness, the{fond-we

exemplilied y a
summer.

Perhaps this is the time for Eortune, as a follow—up of
the article on psychiatry. to assess some of the recent data on depression -— its genetic components. relations to alcoholism, modification
by drugs. maintenance therapies, and the role’of’nechanism of action
of convulsive therapies.
'

Should there be a story here, I would be glad to get you
or one of your writers started. It has been a subject of research
interest for me since 1952, and I can provide the relevant literature
and

contacts.

However, there is another story of more direct interest
to the readers of Fortune. particularly those involved with drug
development that could be examined. For two decades, I and others
have quantitatively measured the electrical activity of the brain
the EEG), and used these methods to predict the clinical application
of new drugs in the treatment of the mentally ill. These methods are
based on digital computer analytic methods (we use IBM, others use
DEC equipment).
They have been developed so that specific applications

are

now

being made.

�Most

of the established psychotropic drugs have been

classified into nine major classes, based not on their chemical
structure, but on their EEG effects in man. Using this classification,
putative psychoactive compounds have been examined and for a number,
where their EEG classification clearly fit one of the pigeonholes, a
prediction has been made for their clinical application. These methods
have been successful in defining clinical uses for doxepin, cyclazocine,

mianserin, cyproheptadine, and a number of other numbered compounds.
The technic has also been applied to definﬁki bioavail—
and
neurophysiologic equivalence of different drug formulations ability
issues that are of special importance to the drug regulatory authorities,
and to industrial pharmacologists.

Lately, in applied studies relating blood levels and EEG
have applied pharmacokinetic principles to the EEG measures
measures,
and defined the halfuulife, peak effect and volume distribution of sub—
stances as they afftct the brain ~— another important issue for regu»
latory authorities and industry.
we

to other research
principii of cannabis in naive and chronic
cannabis users; the interaction of opiates and their antagonists; the
study of alcohol antagonists; and to examine brain function in convulsive
therapy and in psychiatric patients who have failed to respond to the
expected treatment where EEG measures provide the basis to specify an
alternate treatment.
topics

~~

These methods have also been-applied

study of the active

Perhaps this issue is of more interest to your readers -—
surely of greater personal interest to me. I would be pleased
to meet to discuss either or both these ideas. Hopefully, the talents
of the writers of Fhrtune could be put to a broader understanding of these
scientific and socially relevant problems.

it is

My

best to your family.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>71.-.,»

m.--

w,

ﬁ—’ﬁrV—W—w-?—V

v~

February 10. 1975

Ms. Carol Tuckerman

Kbbs Associates, Inc.
1133 15th Street. H. w.
washington, D. C. 20005
Dear Ms. Tuckcrman:

-

-

~

-

-—-&lt;

,.

,
;

.-

.
,

.

projects

I

lettsrs

am afraid that your
of December 31, l97h
my work under NIMH 13003, 13358, 19h76 in
to
of NIDA was sent to my former University, and not for«

concerning

relation

until this week. Enclosed are some of the many citations
published during the past six years of these grants. They should
fall into the categories (3). (h), and (T).

warded

..
.~,

”awry“

hmanq

since 1967

may be

In addition,
—

cited

additional

I enclose a

titles

copy of my full citation list
which may be relevant to your mission

and sought, as your

contract

may

suggest.

I trust these are helpful.

,.,_.,

Sincerely yours,

Merd
Enclosures

m

r.

v-

u

u.

run

VB"!

a,

Fink, M. D.
th
Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106974">
                    <text>~‘nuvx

ﬁmpvwvsrpnsw.”w..r.-&lt;w-uw~

«

,...,.. r- ”A.

.. an wan-”M1 1-"...me V'Nw‘m-u

:.

-

arr, 2w; JWN;_ “urn—a

”51%".

mm:

w

was

.«v--."'-Il'“

aura—mam

Februsry 13. 1975
Steven Rossen. Ph.D.
Department of Psychology
.

.

Whip

e

M,“

‘

v.

,._

.

”WM!“

Dear Dr. Roses.

Enclosed are the better reprints describing both human and
animal studies of the peptides ACTH h~1o. The summery paper by Yen Riesen

and Rigter was presented in July, 197h and is the best summary of the
work to date. The supporting studies by Khstin ere enclosed also as

these describe the studies at ESE derivatives uhich have the
amino acid sequence as the ACTH h-lo.

same

“V“

&lt;

,

the date.

I look forward to hearing

‘unm-vwv-"a‘wamsh‘

n—

‘meJ

My

from you

after your

review of

regards.
Sincerexy yours,

Mex

Fink,

M.D.

”WNW

rrwuv

‘

‘

,..t

,

A

7

I

.

,

-

“gm—

�</text>
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v...

,wr

.

w.

.

_.‘ ..H._.

,___,

‘m—y awn-WV

“w“ Wuv'r "Harv-"Wt"‘X!"X“val1'-‘II)U‘&lt;I ‘wW'P—x"‘w-......,.—.._..A .4- mm.

,.

“7....

”-7

February 21, 1975

Thomas Ban, M. D.

Division of Psychopharmacology
McGill

University,

Room

131

Research &amp; Training Building
1033— Pine What

Montreal, Québec
Chnada

Dear Tom:

.

Wm

1m,

.

Thank you for the copy of "Depression and the Tricyclic
Antidepressants" which you so kindly sent me. It is a good summary
of the uniqno views of the Canadian~8wiss schools of psychiatry,
and I commend you on a clear presentation.

Sincerely yours,

ﬁ.—w&lt;~»mr

awry—”NVV‘VMVN.

Fink, M. D.
Professor of Psychiatry

Max
,
,,.
_
A

r”

A...“

v

;
~y.....u.

'v-

”AWWMw.-..x..

mm.

'nvrvl-w‘n

q~,-w-.m~mu«=,

.v

,
v...

..
am

urn-mm;

urn—m:

wax-w

t'rv‘v'v‘

MF:ed

�</text>
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                    <text>Bebruary 21, 1975

Dr. B. K. Shah

Research Facility
Rockland State Hospital
Orangeburg, N. Y. 10962
Dear Dr. Shah:

I thank

there is
of data. I am

know,

you for the many reprints you have sent us. As you
no end of models, and yet, there seams to be a dearth
most interested in the application of these models to

the evaluation of the time course of a drug’s activity in the brain.
In exchange for your kindness, I enclose a reprint of one of our early

studies.

mnny

thanks.
Sincerely yours,

._

w

WWW-

v

“Y

WWW-w..-WVW‘rwr”-FWIWW'FHWW

Fink. M. D.
Professor of Psychiatry

Max

,v-w~..,.,.

MF:ed

Enclosure

�</text>
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                    <text>February 21. 1975

Secretary

Committoe on Admission
The New York Aoadomy of modicine
2 East 103rd Street
Row York, New York
10029
-

‘

Dear

sir:

have known'Prof. Torah Itil since 1958 ~ first as a fellov
scientist; than from 1963~1966 an an nauooiutem at the Missouri Instituto
of Psychiatry; anﬁ since 1966 as a friond and colldborator. I am.vr1t1ng
to ruconmnnd him for modbcrshtp in the Acadamy.

I

1: an outsttnding neurophyuiologint, who has made significant
contribuxions to the quantification of EEG and its application to classia
fioaﬁion of paychonctivn'drugs. ﬁe has keen clinical Judgment and is
internationally known for his evaluation: of new psychoactive substunceu.
Eu

patients.

Ho 13

I

a fins teacher and 1: wall liked by his coavorkorn and

eammond him

reservation.

to your consideration for tollovnhip. without
,

‘

Sincerely yours,
D.
Fink,
m
Profhssor of Payehiusry
M-

MF:od

,

�</text>
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                    <text>February 21, 1975

Dr. F. G. Hermann.
Columbia University College
Physicians and Surgeons
'DO West 168th Street
New York, New York
10032

of

Dear Dr. Hotlinn:
.

for sending me e
It is well written

Thank you

Alcohol Abuse".

copy of "A Handbook on Drug and
and reeds easily.

Since the time when we chatted about the narcotic antagonists,
been some progress - notably, much testing of neltrexone has
has
there
shown this drug to be superior in efficicy and toxicity to cyclezoeine.
Chen next you issue reprintings, it would be helpful to bring this
section up to date, as the work is active.
Again,

my

thanks.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Hex
MF:ed

�</text>
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                    <text>cruv7-(w“wgwuv—‘IWVVWV‘VL""‘V~WWW;'q-mv—wvv&gt;r.)wﬂ~snwv|wlw
m

A».-

,
i
v . v m.“4. WWW”.
1.4:. w m -7...
.. ”“7
w~,.~.qv._mnwr.:.m
rw
-

-

v

.

.‘

‘ww..-

1n:

*ﬂ‘)‘

my.

‘

_r7"

February 2h, 1975
Buoy Jane King, M. D.
Virginia Commonwealth

university

Medical College of Virginia

MCV

Station
Virginia

Richmond

23298

Dear Luyy:
Thank you

for your kind remarks.

unilateral electrodes,

Pa. , 191mb)

with one of

When we

needed

obtained them from Medctnft (Skippack,
and in 1969, they were catdog No. 1031 and cost $18.00.
we

interested in a working document that I edited
co~workers at that time for our residents. Although
dated (June 1969) I think it is satisfactory for your

You may be
my

it is slightly
library.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Mrzed

Enol.

�</text>
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                    <text>February

2!,

1975

Mr. Bruce Richmen

Baylor College of Medicine

Texas Medical Center
Koueton, Texas 77025
Dear Bruce:

Thank you for the copy of "Drug Issues in Geropsychietry." The
volume, like the earlier one, shows how little we know of the special
problems of drug use in the elderly. It's a good volume (although I
found the typeface a bit smell), which I will-support as reading to my

residents.

Encloaed are some preprints of our recent work.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

Enclosures

�</text>
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                    <text>Wm WT...- ﬁr “WV—mm-

nv-vw'

.»wwm"ww.ﬂw

March 10, 1975
Ms. Maya

Pines

Washington, D.C. 20008
Dear Ms. Bines,

is a report written last
status of the research efforts in the peptides.
Enclosed

May

on the

Since then, some Of the reports have been published;
the studies in convulsive therapy have had some preliminary results;
and studies in the elderly and mentally retarded have been designed,
funded, and are in progress.
WW.“

N__

n"...

The

latest findings are those reported

by David DeWied

effects of vasopressin; the studies of Kastin supporting
central effects for ACTH h—lO; the reports by Itil that THE, another
polypeptide has CNS effects; and the animal studies by McGaugh,Gold
on the

CNS

and van Buskirk.

I trust these data are of

some

interest.

Sincerely yours,

~.....

_,.__,......-m

'v‘m‘w"wnrJl-remI-5Wun._.wv

nw-wr

r~
ran

.

-A

..

.
‘9‘“.

WW.

rem“

Professor of Psychiatry

�</text>
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                    <text>March 13, 1975

Joyce Small, M.D.

Street
Indianapolis, Indiana

1315 West 10
Deer Joyce,

pleased to enclose a copy of the final report of
our study of DH-52h (fenmetasole). we had spent a few months
defining the EEG effects of the substance and were convinced that
we had a good profile. To verify this classification. we suggested
a definitise cross-over study. we suggested this, a step that was
consistent with our original protocol, only to have the monsters

I

am

refuse to supply drug for additional studies. This
prepared, reluctantly, as a final stateeent.

summary was

I have had a chance to read a report by Mendelson on
the lack of alcohol blockade for this compound. I believe that his
study. which was poorly done and was not definitive, may have

tipped the scales against further studies of the drug.
On anapher matter, I have been called by Sol Goldberg
to ask whether I would be willing to act as an ad hoc site visitor
to an application from your laboratory. While I felt that I could
act reasonably impartially, I did indicate to him that we shared some
common

interests,

and

that he should ask your approval before

making

arrangements. I would, as you know, be pleased for an opportunity to
visit with you again.
conplete~~

My

it

best regards. Tell Iver the 33? program is almost
should get off my desk during the next few days.
Sincerely yours,

v4

«-

.g

2“
..-.

v.
1.

T

«www-

:
,..

&lt;-

V“.&gt;~

.

'.

-.W~"‘(Ws2-"WW-‘W‘

13;.-

.\

r
:
’.v";¢

,-.,..

,
'9

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>vawwr
'3

r .-——-—w.-m.....nwwvwryuﬁx-‘vmj-IV'

-

“nuns "Wu '7. 'mﬂ,*\ww~v-I\Winlnwm

W‘- y-o-‘a‘w-p-“szvnW‘s"! -rL—mm—W‘..w.~,‘ "n”- .m»....,... “v.3.

......—._..

7..-..1WM

w

w." .......

w

—v,

.,7,.Y._».r..er-ﬂ

. ".7 _

'. ‘1

'rm-

s‘r"'w:~n

~

March 18, 1975

Robert Marc Hodges,

D.

M.

3720 Hampton Road

Pasadena, California

91107

Dear 'Dr. Hodges:
To

the best of

my

knowledge. no formal documents exist

any of its affiliated hospitals regarding
of
use
any treatment. Such decisions are left to

this University or at

at

cri~
for
the
the
teria
attending physician, subject to the reviews by appropriate Coﬁmittees
of the institutions concerned.
For our teaching of biological psychiatry. particularly
indications for and the methods of ECT, we usually cite our own
publication of 1970 (Convulsive Therapy - Methods and Applications),
the 1972 special issue of Seminars in Psychiatry dedicated to
Convulsive Therapy, and the l97h volume, Psychobiology of Convulsive
Therapy, edited by M. Pink. 8. Kety, J. McGaugh and T. Williams,
(Winston. washington. D.

I trust these

6.).

comments are

helpful.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

.

.m

..

.- ._‘

.

,V

w. w

_.

..__...,_ . ..l._ v -7.

�</text>
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                    <text>m‘w‘w -W'r-v-s-n-»—'~»v~-~r—-w»war‘muvw-m‘y‘r‘wvwww

”4......"

Ex

March 21, 1975

John Stern. Ph.D.
Department of Psychology
weshington University
St. Louis. Missouri
Dear John.
—

mum-v"

Thank you for sending the reprinn on the analysis of eye
movements. It came at e particularly opportune time, for I hsve Just
revieved e report from the Chicago group of Holtmen, Levy. et 31.,

measured eye tracking of schizophrenics as the subjects followed
They used hand measurements for their scoring, and I was
wondering whether there was not sons way of measuring this talk more
who

a pendulum.

rr-nvrw—mwm-wnv-«rq-

precisely.

delighted to see that you had developed a method, and I
ask whether I might see s copy of the Harley report on
to
writing
and
the progress report on the effect of alcohol. (Did
method.
the
alcohol affect the saccadic measures. and if so, at whet dose and
time after ingestion?)
-

w—wzuv

«W-Wwawc-.=:Ww

,

am

I

wee

Many

-

thanks.

uvr-lev-‘ww-

Sincerely yours.

,e

Fink, M. D.
Professor of Psychiatry

Max

.

A.,u.-v

Y

r.

.

.m-

�</text>
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150 White Plains Road
Terrytown, new York 1059,
Deer Turen,
Our work in bioeveilebility is described in the enclosed
reports, from 1971, lQTh end our latest. "Relation of EEG to Blood
Levels of Peychoective Drugs". The lest will be yubliehed by Merlin

and Gottechnlk.
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A

report to the

two weeke.

APA

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end

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but it essentially

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replicates the report in your book.
My

wqmwmmrmi

best.
Sincerely yours,

wwwummmanc

wee-“m

5w

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Wm

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Fink, M. D.
Professor of Psychiatry

Mex

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                    <text>w A: ”w“. ;.,._

.

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m-“ m..-.- v.‘mm~._ﬂv

V

- .m.“ . .7 .w. w...........,.,

VFW H- WWW... .7. l”...V.W—.—.

March 29, 1975

Julian

L. Barman, M.D.

Department of Pediatrics

The Chicago Medical School
2020 West Ogden Avenue

Chicago,

Illinois

60612

Dear Dr. Berman,
Thank you for the kind invitation to be considered for
the position of Chairman of the Department of Psychiatry. I regret
that I cannot face relocation again, and cannot apply for this
positéon.

If he is not already on your list, you may wish to
consider Charles Shagass, M.D. of Temple University. He is an outstanding teacher and researcher, a political leader (President of
the American Psychopathological Association and the Society for
Biological Psychiatry). and well liked by his colleagues.
Sincerely yours,
.

n

imw'm

Fink, M.D.
Professor of Psychiatry

Max

w

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                    <text>‘1-

.w-pr‘n.

.

.&lt;-nun-wrm.Wmﬁw—Hrun'1‘33rmvu;a.“

,

wwwrwr‘mywwn-..-..-..,.revenw...vgaw'w’

V‘thwrrm'l-

-.«.

March 31. 1975

J. Goethels, M. D.
Philips-Dupher, BV
Centrele Bibliotheek

A.

P. O. Box 2

weesp
The

Netherlands

Deer Dr. Goethele.

Enclosed is a reprint copy of our report. "Quantitative Analyses
of the Electroencephalogrem by Digital Computer Methods, Publication
No. 66-1, 1966", en requested. The 65-10 requested is no longer

available.

volume,
If possible, we would ask reimbursement for the enclosed
Inc.
IAPR,
h02.5h.035.2§67,
account
to
12
deposited
at
guilders,
Algemene Bunk Hederlend, 78 Vijzelatreet, Amsterdam.
Thank you

for your request.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed

Enclosure

m..-“ -_. qr we...“ m7

-

-

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.

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�</text>
                  </elementText>
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“mm—"v.“ —'1

rm»... WW.NWawn-“mm

.

WW mvw—w w

‘w—,-—¢mu-r.muvﬂ.w
,7

m'

.

..

4x.—

.
.
V.ww— .— ——-———.........._
WIJVV"1_v—s—wv—wv—ww

.

.—

.

.

v.

.

r...

. v—-

_

war l.

w-v—vmmw‘

....—.r-

m

~m-

n-m—n-

,,

.v...

.
—...-

-Merch 31, 1975

A.

J. Goethals.

M. D.

Philips-Dupher, BV
Centrele Bihliotheek
P. O. Box 2

weeep
E

The

Netherlands

Deer Dr. Goethele,

Separately we have sent e reprint copy of our report,
"Quantitative Analyses of the Electroencephalogrem by Digital Computer
Methods, Publication No. 66-1, 1966!, as requested. The 65—10 requested
is no longer available.
-

at

12

Bank

On receipt,we would ask reimbursement for the enclosed volume,
guildere, deposited to account h02.5h.035.2667, IAPE, Inc., Algemene
Nederlend, 78 Vitzelatreet, Amsterdam, if possible..

Thank you

for your request.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

Merd

�</text>
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                    <text>W

STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

Stony Brook. N. Y. 11794
Phone: 516-444-2447

Laboratory

April 2,
P. H. Van Oot,

1975

M. D.

University of British Columbia
Department of Psychology
2075 Wesbrook Place
The

Vancouver, B.C.
Canada, V6T

1W5

Dear Dr. Van OOt,

still

It is good to hear that seizures and seizure therapy are
of research interest.

Your finding of increased tonus in successive seizures is
‘consistent with the experience that repeated seizures are followed by a
lowering of the seizure threshold. When current factors are held constant,
successive seizures exhibit prolonged duration. Spinal fluid acetylcholine
levels rise and the characteristics of the seizure change so that the
post—seizure EEG shows longer and longer silent periods. The interseizure
EEG becomes slower in frequency and higher in amplitude, and the duration
of persistent slowing is directly related to number, frequency and intensity of seizures. Thus your observation is a facet of the oft—described
neurophysiological consequences of repeated induced seizures. I trust that
in your report, you present data for varying intensities of currents, and
varying numbers of seizures.
comment on the interaction of alcohol and
note suggests the finding was a surprise. Surely,
effects of seizures and of alcohol should make

It is not possible to

induced seizures.

reference to the

Your

CNS

synergism a possibility. Fortunately, such synergism (if indeed it exists)
is not common in clinical practice. One would hope, should you pursue

this line‘of inquiry, that
quency of

ECS; dose

you would carefully specify number and
of alcohol; and the time factors.

fre—

principal reason for answering is to comment on the tone of
It is a potentially
anthropomorphism in your letter. Rats are not
unfortunate extrapolation to speak of "dangerou interaction" and to
join ECT, alcohol addiction and dependence in as complex, unclear
My

sentence.

HEM.

�P.H. Van Oot,

I

M. D.

April

—2—

O
C-

a

1975

recall citations relevant to the question of
although there are anecdotal reports of ECT used
successfully in opiate and alcohol addicts. I have not examined

alcohol and

cannot

ECT,

this combination directly.

For references you may seek the studies of George Winokur
in alcoholism and depression; and Ferris Pitts in ECT.
I can recommend the volume, ”Psychobiology of Convulsive
.Winston, Washington, 197M) and the January, 1972
”Therapy",
issue of Seminars in Psychiatry as sources of review of the neuroof ECT.
fghysio ogy
(V.

,

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Ilax

Merd

�</text>
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                    <text>WWW-..

-'..........U.._..vs

~WVW.

mI-'

,

m

rr—wvw—v-w-w—

‘\

\

April 5: 1975
Mr. David

Gelernter

13h3 Yale Station
New Haven, Uonnecticut

06520

Dear Mr.

Gelernter,

had some

difficulty in deciding what our summer schedule will be.
At this time it is unlikely that we will have a

I have hesitated to answer your

letter as

we

have

project in progress for which your participation would be suitable.
I would recommend that you seek another laboratory in which to
continue your interests during the summer. It will probably be

more rewarding.

Should you be on the campus this spring, come
Thank you

for your interest.
Sincerely yours,

Max

Fink,

M.D.

visit.

�</text>
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                    <text>w w~w~rmm1rf ”WNW
un-sr-

———rv~ ‘-

,

.Z‘r'rwv‘u

April 9. 1975

,v
1—;

~
~

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V

J.

Thomas

UCLA

Ungerleider,

M.

D.

Depertment of Psychiatry
760'Weetvood Plaza
Loe Angelou,

Calif.

-

9002h

Deaerr. Ungerleider.
Contemporary Peychology'
congratulate you on an excellent

I have Just reed your review in

to
evaluation. When I first read his volume, I van shocked by his,
biea and relegated the volume to the polemic: on my shelves.» But,
and appears frequently
unfortunately. he in verbal and voluble.TV.
and
I think he does much‘
radio
in new York on school panels,
harm.‘ Your advice to the render. to-evnluete the vork. is excellent.
of Behae' volume and uieh

-

studies in Greece are finally coming to a conclusion.
report as submitted to NIDA at
I am pleased to enclose a copy of thework
is now being prepared for a
the conclusion of the contract...The
the texts_vill
presentation-—hopefully.
more conventional, aeientific
end of the
the
before
co-euthore
vetioua
meet the approval of the
knowledgeable
number
of
a
summer. I have distributed this report‘to
by HIDA
released
until
direct-attribution
experts on the beeia of no
Our own

or published.

Again,

It

may

my

interest

you no

it is.

thanks for an excellent review.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed
ENC.

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                    <text>My

w,,_—...,__~.

..,

_...,,,,,.,.

aura".-

m

~&lt;forvn1x

—uu-

April 1h, 1975
Dr. Austin H. Kntscher
630 west 168th Street
New York, New York 10032
Dear Dr. Kntscher.

for your invitation to submit e manuscript on the
use of andipsic drugs in the dying patient. I regret that I am so
committed that I cannot take on this assignment.

I thank

you

years ago, at s eeting on narcotic analgesics in
eckitt and Colman, Hull, England,
described studies with a highl potent analgesic; etorphine, which
seemed useful in patients with terminal cancer. You may find reference
to his work in: Kbsterlitz,ﬁ., Collier, H. 0. J. and Villsreel, J. (Eds. ):
Agonist and Antagonist Actions of Narcotic Analgesic Drugs, Loneonx,
Some

Aberdeen, Dr. Gareth Blane of

Macmillan, 1972.
uyr!

mm.

If

contribute

he hesnmninteined
to the symposium.

his interest in the topic,

he may wish

mm

Sincerely yours,

w

mmrcm

‘fx

"‘5.”

Fink, M. D.
Professor of Psychiatry

Max

‘

MF:ed

bcc:

«rm

vzscW-uwmsv-

V

\

Dr. Gareth Blane

to

�</text>
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                    <text>3‘

n1..~svm~.—m

w: w-mvwvm-wu—p.. -« vs. -.-rm.—.\—~‘
7,,

w—NW-W

mm—v—a—

“T's“ mu

n—‘w—wle-‘m‘w-q. .—..

w—

m (Maw ‘-

\a

mvmmmm—q——-‘vW'I-C-nt-wI'I-Lw—r-mvl-

’5\

April 11, 1975
Michael Dykes, M.D.
AMA

535 North Dearborn

Chicago,

Illinois

Street

60610

Dear Dr. Dykes,

I have had an opportunity to review the chapter #30,
"Antidepressants" and am pleased to share the following notes and
comments. These follow the pagination of the text.
The classification of espression is that which has
pg. 1:
been used for many years. however, in the past decade, other
classifiattions have been developed, and these are more directly
useful in the determination of treatment. The terms: Bipolar, unipolar,
and neurotic depression, with the subtypes of involutional,
depression of the elderly, and post—partum seem to have more use
in regard to drug selection. I urge you to review the classifications

of Woodruff and Guze, Spitzer, and Robins to name some U.S. authors
have shown the merit of a revised classification.

who

This classification is particularly useful in allowing
a place for the use of lithium.in the management of depression as
it may appear in bipolar disease. The omission of lithium may
be a significant omission, despite the fact that the use of lithium
in depression is still in research. This is particularly true since
the report includes the use of stimulants and monoamine oxidase
inhibitors—— two treatments

that are clearly

no longer considered

efficacious except under exceptional circumstances.

statement that 'different patients given the
. ." seems strong to me. The finding
of genetic components is a suggestion at best and 'are' could be changed

pg h:

The

same dose are caused by genetic.

to 'may

be'.

The recommendation

that therapy with the antidepressants

should be started with low doses, combined with the later dosage
recommendations in the individual sections on each compound is unfortunate for a number of reasons. For the most part, these compounds
are effective only when given in 'adequate' dosages] When one asks
clinical psychiatrists who use antidepressants actively, dosages are

)r awn

.

�-2for
rarely started slowly, except in the elderly, and mean dosages PDR
The
in
recommended
the
dosages
mg/day.
250-350
imipramine are
are a bureaucratic hhlance arrived at in discourse by lawyers and
administrators, which somehow is repeated in official reports. In
checking the summaries for the use of imipramine by Klein Davis,
&amp;

Hollister,

Cole

&amp;

Davis, and Fink

&amp;

for the higher dosages.

Abrams, the recommendations are

I believe that a major cause of failure in treatment
with antidepressants is inadequate therapy, and unrealistic schedules.
In a similar vein, the suggestion that treatment should
be given for 3 to 6 months and then reduced gradullly is a plea
for a regimen that is not common in my practice. Patients who do
well, will not continue medication beyond the second month. If their
symptoms persist, they will also not continue beyond the third month,
in prescription
particularly since they will request and obtain a change and
effective
raised
rapidly
are
dosages
in
If
change
physician.
or a
2—5 weeks;
be
in
expected
can
treatment
a
levels obtained,
response
then therapy should be
if sustainedandfor h—G weeks thereafter,
the patient seen more regularly in follow—up. As an
terminated
example of a more vigorous approach to therapy, the recommendations
A

from some European centers for the use of intravenous thymoleptics
given by infusion over two to five days show some promise and their

findings are consistent with the experiences cited above.

The concurrent use of MAOI and thymoleptics may be
pg 5:
recommended under certain conditions, notably in treatment failures
to thymoleptics alone and ECT.
The

last sentence regarding deanol is gratuitous.

sentence should read '
demonstrated."

pg 6:

The

.

.

.

as an

antidepressant has not been

The

suggestion that other agents, as the antipsychotic

agents, may be useful as adjuncts to therapy

is partially correct.

There is considerable evidence that antipsychotic agents (thioridazine,
chlorpromazine) have been iused successfully in treating some depressive,
not as adjuncts but as primary therapy. See refernces to work by
Hollister and by myself and Klein in the early 1960's.

It

seems worthwhile to consoder the inclusion of
to
the use of lithium; since this section is a
some reference
grab—bag of assorted recommendations. With regard to the report of
the unsuccessful use of TRH, this seems a bit harsh since the results
some
are not yet in and the studies are still in progress. There seems(TRH)
and
(deaner)
those
included
rejected
unusual selection of drugs
when the evidence for deaner is non-existent, and that for TRH still
under study. I would be more Judicious in suggesting that TRH is
the first of a series of peptides under study and that such investigations
should be followed with interest.

pg 7/8:

�-3pg 12:

Fatalities are rare,

pg 1h:

Regarding the question of the concurrent use of
I have no experience.

too strong

and the tone of the paragraph

is

guanethidine and thymoleptics,

The combined use of thymoleptics and MAOI has been
based
largely on anecdotal and uncontrolled studies. As
interdicyed
you suggest, lately some authors have suggested both regimens may
he used concurrently. If true, then the caveat on this page is too
strong and the paragraph may be rewritten indicating that some
reports ahve been made but these are unsupported and that combined
use may be given Judiciously. (Considering the low rate of response
of depressives to MAOI, I wonder why anyone would want to use the
MAOI alone or in combination, except specialists who have adequate
hospital facilities at their disposal. From a cost/benefit ratio
analysis, the use of MAOI should be limited to occasional use by

pg 10:

qualified specialists.

Dosages of imipramine are from the PDR and are low..
doses
at night are useful; the reports beginning in 1961
Single
show that the experience has been a lengthy one. See comments page 1.

pg 19:

A few
years ago, I had an occasion to review the data
recommendation
of combined drug therapy. The dosages are low
for the
and the data unconvincing. Unless there is some recent data (since 1972)
to Justify the recommendation of a combination, I can recall no data,
including those presented by the manufacturer, that would justify
the recommendation even on a 'may be more useful' basis. The data
for the successful use of the single drugs doxepin in cases wheree
anxiety and depression co-exist is more convincing, and that conviction
is a weak one.

page 29:

answer your specific questions: for MAOI, see
for single daily dosage, see below; and for
guanethidine, see page 1h.
To

comment on page 10;

It is reasonable

stress

daily dosage for the
at night, since
given
thymoleptics, particularly if this dosage is
MAOI,
For
there
is no such
the evidence of the efficacy is clear.
above).
10
(see
evidence to my knowledge
pg
I trust these

to

comments

once

are helpful. I

am

less than

enthusiastic about the chapter since the fermat follows our under—
standing of some years ago; and I do believe that some progress has
occurred, notably in dosages of thymoleptics; diagnoses; use of lithium;
single administration; relation to ECT;'and the downgrading of MAOI,
stimulants which are reflected unclearly in the present document.
Thank you

for the opportunity to raise

some

questions.

Sincerely yours,
Fink, M.D.
Professof of Psychiatry

Max

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                    <text>May

15. 1975

Ms/ Darlene Warfel
C.V. Mbsby Company

11830 Westline Drive

St. Louis, Missouri
Dear Ms. Warfel,

it

While
is not clear whether further endorsements of
Dr. Hamilton's request are at all necessary, I am writing at his
suggestion. His comments regarding the social problems created
in Califbrnia by some advocates for restriction of medical practice
are factual, and we are grateful for any assistance that can be
given in altering the laws recently approved in that State.
Dr. Hamilton has been an

of choice in medical practice.
appreciated.

active advocate of freedom
help you can give him will be

Any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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May

15. 1975

Siva Sankar, Ph.D.

Children's Psychiatric Center
Bellerose, New York llh26
Queens

Dear Dr. Sankar,

thank you for your kind invitation to join in
the next program of the Eastern Psychiatric Research Association. I
regret that my committments are already too many and I cannot accept
any further engagements for this year.
W

the theme is one of neurophysiology, may I suggest
you invite an abstract from my former associate, Jan Volavka, M.D.
of the New York Medical College, and Turan Itil, M.D., also of the
New York Medical College.
As

My

best wishes for the success of your program.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>May

19. 1975

Richard Markin, Ph.D.

1102 N. Harlem Avenue

River Forest,

Illinois

60305

Dear Dr. Markin,
we have not used the
evoked
changes in the averaged
response as a cerebral index since
1966, and I lack the programs that you request. My work is focussed
changes
on the frequency analysis of the resting, alert EEG as

Thank you

for your inquiry.

it

under the influence of psychoactive substances.

principal laboratory working in the area you
seen interested is that of Dr. E. Roy John at the New York Medical
College and Dr. Sam Sutton at the New York State Psychiatric Institute.
These men are involved in studies of the AEP in cases of MED.
The

.._

.1r

You may silo be interested in following the work of
Charles Shagass of the Eastern Pennsylvania Psychiatric Institute. He
has been a pioneer in the IEP in psychiatric diagnosis and has many
computer programs for such measurnent.

4—

Pedersen on

vish to check the volume by Kellavay and
the computerized EEG analysis as applied to children.

right road.

Good

nu

..

.

‘
.
.'1'

"rm“?

.

«7..

r,"

You may

I trust these suggestions will get
luck.

you

started

down

Sincerely yours,

“an“...r.‘

Fink, M.D.
Professor of Psychiatry

Max

the

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June 3, 1975
Dear

Fritz,

I have read the report, "Diagnostic Problems in
Huntinton's Chorea and Tardive Dyskinesia" by Martin Buxton with
interest. It presents an interesting diagnostic problem with
sufficient detail and breadth to be considered for publication.

It is difficult for me to be critical, since I have
not followed the arguments in either condition in detail. I like
the report, but I am concerned that my lack of expeeeence may
allow me to make an error in this recommendation. Perhaps you would
consider having this report reviewed by John Whittier, M.D. (Director
of Research, Creedmoor Psychiatric Center, Queens, N.Y.). He is the
resident specialist in Huntington's Chores, having followed families
for more than 20 years, and the one man who could provide the
opinion that you seek.
If

the report (after

he agrees
some

that the argument is valid, I believe

style editing) should

Thank you

be published.

for the opportunity to read this report.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>.7.

June h, 1975
Lewis Harness, M.D.
Chairman, Search Committee

University of South Florida
Tampa, Florida.

33620

Dear Lew,

After much discussion among my associates and with
family, I regret that I am undble to proceed with our
negotiations for the position of Chairman of Paychintry. I
truly admire the special unturo or the facilities, the staff,
and the many possibilities at the University, but find that
the effort may be too great {Or no at this time.
my

I want to thank
for your consideration.

you

for your

many

kindnesses and

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mix

ywm

�May

2h. 1975

Lewis Barness, M.D.

University of South Florida
Tampa,

Florida

33620

Dear Dr. Barness,

that I very

appreciated and enjoyed
opportunities are
your hospitality during my visit to
outstanding and the facilities available are among the best I have
seen at any new center. It seems prudent to discuss the many
facets of the invitation with my family and my associates, and I
shall be in touch with you within the next fortnight.
You must know

USF.

much
The

In the meanwhile, I enclose some of the receipts
basis for reimbursement of expenses.

which may be the

Air fate

Taxi (Home to Airport)
Hotel

Total
Again,

my

$176.

8.50

1h.56

199.06

thanks for your kind attention.

Sincerely yours,

Max

Fink,

M.D.

�w.“

—~..W,rmlwr~~m._w..

.

.-.m—-..

-wvvwmmw.” ..,. “Wm rarwwﬁw--."

Lewis A. Bernese, M.D.
&amp; Chairman

Professor

Department of Pediatrics

Tampa General Hospital
Tampa, Florida 33606

Dear Dr. Barness,

for the invitation to visit Tampa and
I have scheduled the flight, Delta 17? leaving
LaGuardia at 0900 and arriving Tampa at 1132 on Tuesday, May 20.
As I shall be going on to Miami Wednesday afternoon, there should
be enough time to visit the installations of the University and to
meet the faculty.
Thank you

the medical school.

I shall be prepared to present a discussion of
"Studies of Chronic Hashish Use", reflecting on the studies in
which I have been a participant since 1969, both in New York and in
Athens, Greece. I should like to review the clinical, behavioral,
and physiologic effects of cannabis use, both in a community of
chronic users and in experimental subjects.It should give the audience
an opportunity to enquire into the relations between laboratory and

field studies.

It

to read any material describing
its facilities, and its present
and projected programs that may be publicly available. I should be
grateful if your office could share such material with me.
would be

helpful for

the dIIelopment of the medical school,
Again,

my

me

thanks for your invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_..

�</text>
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                    <text>June

5a

1975

Gerald L. Klerman, M.D.
Harvard medical School
Boston, Massachusetts 0211b
Dear

I

was

Gem.

I. too,

enjoyed the session on Depression and although
enxious
about the materiel before the session, I was
quite

pleased with the result. l have received many favorable comments
from ley as well as professional friends ebout the ECT presentation.

is the present draft of the report

you requested.
some
the
excuse
so
for
publication,
are still re~writing
paper
of the typographical errors and ambiguities.

we

Enclosed

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of PBychistry

Max

�</text>
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                    <text>6,

w

June 25. 1975
Mrs. Jan Boppe
2957 Kalakana Avenue
Honolulu, Hawaii 96815
Dear Mrs. Boppe,

It was kind of you to write after seeing the film on
depression, to tell me of the tribulations in your family. Unfortunately,
the story that you tell is all too common, and all the sadder since,
as you note, more could be done for many of the mentally ill of
America, were the press, the professions, and particularly the
law willing to exercise restraint and good Judgement. The press is
guilty for expanding on the mysteries of our treatments, and for
equating all biological treatments as shock treatments. The very
language is forbidding. The professions (medical and psychological)
are at fault for not insisting that all treatments that are
useful are equally to be available and to be used, insisting that
some are not 'cleaner' than others. And the law, for daring (as
they usually do) to interfere in the relationships of patient and
physiscian.
The

results are often the tragediy that

all too eloquently.

you recorded

My associates and I continue to study the convulsive
therapy process. I believe we have learned much and are now planning
yet another series of studies to improve the treatment process; and
another conference which may be useful to educate our peers.

Again,

my

thanks for writing and sharing your experience.

As a separate thought, should you be interested, there
devastating article about ECT published in the New Yorker
in the summer of lQTh. The article was written by B. Rouche. He
tells the stody of one patient who received ECT inappropriately
and complains persistingly about memory loss. His biased article has
been qudted by many patients who wished not to have ECT. Should you
get the article, you may wish to write to him and express your story.

was a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Executive Director

Max

�</text>
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                    <text>October 3, 197h

Sylvie Levin,
Th Round

Hill

R. N.

Road

Roslyn Heights,

N. Y.

11577

'

Dear Ms. Levin:

I have not worked with nicotine, nor do I have suitable
references in my library. There has been a volume on nicotine
published in a series by V. H‘ Winston and Sons during the past
year.
The only scientist that I know that has been working
Dr. Murray Jarvik, who is at the V. A. Hospital in
Brentwood, California. You may wish to write to him regarding
the evidence for dependence on nicotine.

actively is

Most useful may be a letter to the NIMH Information
Service at 5600 Fishers Lane, Rockville, Maryland. They have
materials which would probably be the starting point in depend—

ence on nicotine.

It is interesting that you have raised a question which has
not been studied in my Lab, and I regret that I have no personal
experience with the problem.
'

"rm—m,

w

Sincerely yours,

w"

‘1Iﬁm.\rﬂ'7‘

,..._.,

any,"

“ml

t

.w'

Fink, M. D.
Professor of Psychiatry

max

“rm-WW7,

Mmzed

'

�</text>
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                    <text>October 8, 1973

Peter Siegler,

K.D.

Htrrell—Nn$1onal Ldboratories
PO

Box 8203

Philadelphia, Pa.
Dear Dr.

19131

Siegler,

Octdber 3, I subaitted a revised page 8 of
our protocol. dated 6.26—7h. That revision was incorrect and I am
enclosing a praper revised capy at page 8. Please destroy tbs one of
last week and substitute the enclosed page.

In

my

Many

letter of

thanks. Our work is proceeding wall.
Sincerely yours,

Fink, K‘D.
Professor of PSychiatry

Max

�</text>
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                    <text>September 13,

E. A.

Reinstein,

M;

197%

D.

Profeaaor of Neurology
Mt. Sinai Hospital

100th Street and Fifth Avenue
ﬂew York, N. Y.

10029

Dear Ed:

Enclosed are 25 copies each of two reports which may be
distributed to the students in the seminar, "Disorders of
Language and Cansciousneas”. I plan to discuss these as back—
ground fbr problems of the effects of drugs and ECT on brain
function as used for therapeutic purposes.
Again, my thanks fbr your invitation. I understand
to be at the Rumpus Room on 98th Street and Fifth
Avenue, at 2:00 P.M., October 31.

that I

am

My

best regards.
Sincerely yours,
x Fink, M. D.
Professor of Psychiatry

B

Merd
Enc.

�May

28,

1971;

“1'4

—

u
vr‘
u

{rmmgqr

Edwin A.

Whinstein,

M.

1212 Fifth Avenue
New York, N. Y. 10029

D.

.

Dear Ed:

I

would be pleased to discuss my experiences with Em,
psychoactive drugs, and language on either October 31 or Novem1971:, at Mt. Sinai. I an, at present, free both days and
ber

l,

leave the scheduling to your Judmnt.

Sincerely yours ,
Fink, M. D.
Professor of Psychiatry

Max

liked

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                    <text>Miwq

October 25, 197“

william Martin, M.D., Director
KIMH Addiction Research Center
P. 0. Box 12390
Lexington, Kentucky

’

Deer

Bill

h0511

Richard Reenick, M, D.
New York Medical College
Department of Psychiatry
5 East 102nd Street
New York, N. Y. 10029

and Dick:

The enclosed

letter

from Raphael Nechoulam speaks

for

itself.

do indeed have a smell supply of A'—THC-DMH.
I will be glad to
make
available to either of you should you wish to undertake a

I

drug

it

test.

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Mex

Merd

Enclosure

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                    <text>October 25. 197k
John Stern, Ph.d.
Department of Psychology
Washington University

St. Louis.

Mo.

3w-

Dear John:

for lunch. On Thursday I was able to
visit
Ierjenorry to see how quiet and how
empty the laboratories were. The few girls who are left are quite
depressed and it is a tragedy that the leadership was unable to keep
this fine Institution going.
Thank you very much
the institute and was

I learned one fact,which should have been brought to the
attention of the public in 1962. When the Institute opened, there
were more than 2500 patients at the St. Louis State Hospital. The
Chief Nurse tells me now that their census is down to less than 500
patients, and that to fill the empty halls, they have moved aged
and mentally defective patients into the Institution. Sheltif the
public should have been told that much of that reduction, which far
exceeds the reductions in New York State with which I am now acquainted,
was the response to greater care more physicians, etc.
I was puzzled as to where I got my erroneous dates for SPR.
Please note the enclosed which led me to mark my calendar. I also
am sending you the only other communication I received which makes
no mention of a change of date.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

Enclosure

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                    <text>'

E. H. Uhlenhuth,

M.

1,

November

1975

D.

University of Chicego
Department of Psychiatry
950 East 59th Street

The

Chicago,

Illinois

i

a

I

60637

Deer Uhlie:

E

§

’

‘

E

.
_

enclosing e few of‘our more recent reprints of
the effects of enti-enxiety agents on the EEG.

I

E

,

em

‘

to these reprints. you may wish to obtain
some of the papers'vritten by Itil. who hes eeserted‘thet the
anti-anxiety agents have e specific EEO profile.
In addition

I trust these ere helpful.
Sincerely yours.
Fink, M._B.
Professor of Psychiatry

Mex

MF:ed

Enclosures

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                    <text>Havcubar 1, 197h

Tektronix
P. 0. Box 500

-

Beavnrton. Oregon 97005

Gontlamon:
.

I would appreciate a aopy of your 197k catalog for
liberatory equipment for tha use of my Laboratory.
Thank you.

Sincerely Yours;
Fink, M. D.
Professor of Psychiatry

Mb:
MF:od

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                    <text>November 8, l97h

Elliott Richelson,

M.D.

Johns Hopkins University School of Medicine

Baltimore, Maryland

Dear Dr. Richelson,

For a number of years I have been studying the
effects of standard and novel psychoactive compounds. In answer to your inquiry, I have examined the compounds under study
CNS

find that

classification of 'antipsychotic'have not assessed a new antipsychotic since our studies
indeed,
of butaperazine, thiothixene, and trifluperidol-— and none of these
would fit the sense of a 'new neuroleptic'. I regret this fact, and
thank you for your inquiry.
and

we

none would earn the

My

best regards to Professor Elkes.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>November 20, 197h

E. N. Terry,

M.

D.

Medical Director
Pharme Research (Canada) Ltd.
250 Hymns Boulevard

Points Claire, P.Q., Canada
Dear

Stitch,
I was pleased to review the data for the

compound

Si 93.

The volume consisted of three parts: pharmacology and toxicology,
dated 19 August 1970; clinical pilot studies dated November 2, 1972;
and psychometric studies dated June 17. l97h.
:m—

wmw-ww

The pharmacologic evidence indicates that Si 93 is atropine—
like with tachycardia, mydrinsis, and dry mouth as predominant symytons.
It is readily absorbed and at high doses inhibits gastric secretion.
The anticholinergic actibity was also manifest in EEG studies-in
rabbits and cats where 81 93 exhibited atropine-like patterns. The

anticholinergic activity suggested

its

use as a spasmolytic.

In the clinical studies, the dose range is defined. At
there were no effects. At ho mg. anticholinergic and sedation
occurred. At 60 mg, the subjects complained of fatigue and drowsi5 mg,

.

&lt;

ness in addition to the anticholinergic effects. In a crossover
controlled study of 25 ng and 50 mg Si 93, the differences between
the two doses were small with greater changes in pulse rate for the
25 mg dose.

«luv-v

nun-m

nu-~4-uexlrw-mu—wxrﬂ

g
m...

.m—v

v“

mwn.mrv'ﬂil‘ﬂrr”"

,‘I'VIVFIE

—'vr‘4

—v

test data reportﬂ’interesting findings.
Eight volunteers were seen in a double-blind crossoveg;gtndy of
SI 93 Ild25 mg and 50 mg, oxasepen 20 mgI'IE’E'EOnparison substance,
and placebo. The 50 mg dose of Si 93 elicited greater sedation than
20 mg oxasepan. but also an inner "stimulation". irritability, unpleasantness. feelings of warmth, and some clouding of sensorium.
The 25 mg dose of Si 93 vss found to be pleasant and equivalent to
The psychometric

oxssepan.

�,valnlrm...“ VW'K‘:"F .,

)

;

___.-

er.

,

.
y'vsc. .Y.. _new-m.,.. a._ “wees—w'cv a .&gt;.. W2...”,

.Inﬁu-VHW .“m-v.

V

V

mm “4’".'—'
v

—

-

~ V--

~

'3

1-

.
sn-Mr-w

rv-mww

»

4-,“ w -m n.

—

»

e.

LF—IGY‘
,, wan-VB;w-:’atv4‘lr:'t¢:gr:aw{v-a

.

‘

/

4

E. N. Terry, 14.1).

-2-

November 20, 197k

These observations strongly suggest that 81 93 has central
at
activity the doses studied; that the activity is pleasant and
'tranuillisina' at low doses, but unpleasant at high; that there
a relatively narrow therapeutic range, for the 50 mg dose elicits is
'some of the central deliriant effects of the
anticholinergics. There

are

interesting questions about the compound:
Are the central effects similar to oxasepam (and other
benzodiacepines). or like imipramine (ditran, and other thymoleptics)?
some

‘Does 86 93 have a

at lower doses,

diphasic effect—~sedative and pleasant
deliriant at higher doses?

and stimulant and

These questions can be answered by our present methods or
electrophysiologic assay, for a classification study will define the
Atype of central activity in man and yield evidence of its
therapeutic
range; and a dose-ranging study will give data for the stability or the
nature of the central effects.
'

However, the questions that must be answered by management
before these studies are undertaken seem to me to be: Is there a need
for a novel thymoleptic; and it there is, can 81 93 quality for further
study since it may have a narrow therapeutic range?

If

the answer is affirmative and further studies are desired,
to examine this compound. For a dose—finding study,
single doses of 5.10.20, he and 60 mg should be examined. FOr a classi~
fication study, two doses and placebo could be examined in 10-12 sub-~
Jects over a post-drug four hour period with measurement of EEG, alert.
ness, heart rate, blood pressure, mood ratings, symptom ratings, and
critical flicker fusion (CFF). and the observations compared with our
historical standard? diasepam and imipramine.
we

would be pleased

my

thanks {hr the opportunity to review these data in

It

seems

to be an interesting centrally active

originals.{

My

compound.

their

German

.

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

Merd

Again.

“ah-

.7

�</text>
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                    <text>November 22, l97h

Dear John,

It

was good

cooperate in any
coming

way

Should you

trip
I

to hear

from you, and

that I can.

like to visit

me

in

I shall be delighted to

New

East, I should like to share

my

York during your forth—

schedule;

'

leaving for San Juan on Tuesday, December 10 (AA653
12:30).
Monday, December 9 is quite free except for a
at
mid—afternoon.
the
in
lecture
from JFK

am

I plan to return from San Juan on Saturday, and am free on
December
16, not on the 17, and then from the 18th on
Monday,
time
can set any
you wish.
Before the

December 7.

ACNP,

I shall be away, returning late Saturday
V

I look forward to meeting with you.

My

best regards.

Sincerely yours,
Fink, MDD.
Professor of Psychiatry
Max

�</text>
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                    <text>V“, m,,.-_.._lV....V.....‘..w-,.-A

‘pmwwp_m_~._~

.

waqw

,.

,

mar

November 29, l97h

Mrs. Eva

J.

LIJ—HMC
New Hyde

Park,

Meyer

Research Grants Manager
New

York

Dear Mrs. Meyer,

I enjoyed the opportunity to review the two proposals
submitted by Dr. Struve. The one on agorophobia and mitten patterns
seems wotthy of support, although I believe the estimate of time
and cost is probably underestimated by at least 50%.
I could not Judge the review proposal since there is
data missing which would assist me in my determination of likelihood
of success and worthiness of support. Should the proposal be
submitted again (if unfunded), I would be willing to review again.

to the suggestion that one reviewer believes the Bumitten
clinical significance, that is the question which Dr.
Struve is attempting to answer. At present, it is probable that
few observers can elicit the B-mitten and that the pattern is
inadequately studied. Precisely for this reason, Dr. Struve should
be encouraged to continue his explorations and if he finds or
comes to understand the significance of the observation, bb teach
not to

As

have

us, so that

we

can apply the data in our

clinical

work.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry
Max

�</text>
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                    <text>June 6, 197k

Biesen,

Hank van

M.D.

Scientific Devetopnent

H.V. Orianon

Group

Oss, Holland
Dear Henk,

Hurray

I have received and read the protocol from
and believe that he has expanded his

Jarvik,

interest in memory mechanisms to encompass the
peptides. The protocol is apparently a part of a
large application for research support, and I an
sure that making 01—63 available should add to
the information on the central effects of the
peptides. His review of the literature brought out
additional references which I will get.
Enclosed is a set of reprints from my
earlier work on the effects of drugs (chlorpronasine
and inipranine) on various perceptual and attitudinal
tasks. For comparison, I an also including the results
of induced convulsions (ECT) on these tasks; and when
I was deciding on the ones to select, I found one
or two additional references that bear on our mutual

problems.

is sending Hrs. Rosselson, his
laboratory next week. Thinking
of her visit, I recalled some discussions regarding
T. van LierOp—- is there some merit in having his
2
Leo Lange

technician, to

my

visit

It is already

June;

my

staff are thinking

about the summer holidays.;ny daughter Rachel

is

graduating high school at the end of the month and
we face her leaving for the university soon. The
weather has been fine and we have had some good
week-ends in our country home-- not many fish, but
plenty of repair work.
See you next month in 083 and/or Utrecht. My
best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>June 7, 197h

Richard Resnick, M. D.
New York Medical College
Department of Psychiatry
5

East 102nd Street

Rev York, N. Y.

10029

Dear Dick:

Reading reports of the work of Tennsnt on

Darvon—N

brought to my attention that the principal toxic effect of the
compound may be in its seizure inducing propensity. Nowhere did
I find evidence of CNS studios.
Should you wish or be able to assess Darvon-N for its
withdrawal use, examination of the EEG records would provide an
objective (and obvious) answer to the question.
A

n

I

a

who».

«.1

would be glad

WW

My

nu-

a.

to cooperate in such a study.

best regarts.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

�</text>
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                    <text>"-v'

TIN-W
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June 7,

1973;

lv'umx-Ll‘l

,.-p_--

WW.7_»V.

r—rvrv.

:,
'I-z

w-x.

l'ﬁ’vmcivuryrw"

Mr. William Resell
V. H. Winston &amp; Sons, Inc.
1511 K Street, N. W.
Whehington, D. C. 20005

Dear Mr. Begcll:

I want to thank you for the ten voluaes. Before I could use
I
these, received two packages from Wileyb'twenty volumes each.
Rather then return them, I have accepted and paid for the two ship~
meats.

What do you wish me

to

do with

the ten

volumes you sent me?

Sincerely yours,

Max

M. D.

‘

MD:ed

P. S.

Fink,

Department of Psychiatry

exhibitors at the Society of Biological Psychiatry,
British Neuro—
no meation
logical Association were busy. Unfortunately,
books
were
(Holstead)
Volume!
Wiley
ECT
Other
of the
they
(Reitan)
suggesting
in
some
still press volume. I am enclosing
exhibited,
a
this
ignoring
are selectively
information.
for
Academia
your
listing
copy of the

The

American Neurological Association, and

�</text>
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                    <text>June 11, 197h
/

“K5,"!

{oven Simeon,

M.

D.

Missouri Institute of Psychiatry
shoe Arsenal Street
St. Louis, Missouri 63139
Dear

vaon:

At the ECDEU meetings. you delivered the EEG data cards
and a protocol for the Mellaril Dexedrine, placebo study in dis~

turbed children; with a request that we suggest additional analyses.
To get a better idea as to what has been done, you recommended I
discuss the data with Dr. Hugue.

I did so today. and was told he has completed t~tcst ,
discriminant function, regression, stepwise regression; and d
analyses. He does not have a copy of the report, but recalls
being able to discriminate drug effects. He also recalls corelational analyses using behavioral variable with the EEG.
Before recommending e data analysis, it would be useful
to hone the reports of the previous analyses,tor a sfmple replica- It
tion of analyses would serve little useful purpose. If you lack
the reports, perhaps Turen has copies in his files; or, even they may
still be at MIP.

I will hold further processing until I hear
My

from you.

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

Merd

�</text>
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                    <text>June 12,

Larry

O.

Rouse,

M.

197%

D.

California State university, Fresno

School of Natural Sciences
Fresno, California 93710
Dear Dr. Rouse:

I have read your interesting suggestions regarding antrainment of alpha activity with hiofeedfsck training and the use
of "reverse tolerance" to LSD for the modification of epileptic
behavior and electrophysiology. The reprints you requested are
enclosed, as are the citations.
While I have no intentioxnof engaging in a long-distance
argument, I would like to question the concept of "reverse toler—
ance". This issue has been raised anecdotelly by street users of
cannabis. we examined the problem and found that tolerance in the
classical sense occurred and that "reverse tolerance" was not a
direct phermscologic but a "set" effect. Are your observations
with LSD sufficiently well controlled to demonstrate physiological
hypersensitivity (i.e., reverse tolerance)? Since heart rate and
pupillary also both change with LSD, perhaps you could use (or
have used?) these objective indices? In our studies of daily ed—
ministrstion of LSD in schizophrenic patients, we found tolerance
development to be rapid, occurring to three daily doses.

I trust these reprints serve your purposes.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max
:

MF:ed

Enclosure

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                    <text>June 17 ,

Joyce G. Small,

M.

1971:

D.

Lorne D. Carter memorial Hospital
1315 Vest 10th Street
Indianapolis. Indiana h6207
Deer Joyce:
My associates, Peter Irwin and Steven Knhn, ret
with the information we requested. There may be enough for
analyses and we will lohk at them in the next few weeks.

Q14¢/

you for your information on DH—Szh. we
have begun our dose-finding and it is encouraging to know them the

I

want

to thank

clinical effects.
When I was seeking a PI 6208 in the New York area, 1"
celled California and was told that the machine was no longer made
nor eveilahle. I left my name, however, and received a cell on
June 1h from Jim Jordan, beon Electronics, (71h) 556-6500, saying
that he has located a PI 6208. If you are still looking for one,
or if you wish to reserve one in the event funds become available,
you may wish to give him a cell.
compound has

It

was fun

my

best regards.

from Oregon.

being with you, Iver, and our hypomenic

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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Joyce G. Small,

M.

1971:

D.

Lorne D. Carter memorial Hospital
1315 Vest 10th Street
Indianapolis. Indiana h6207
Deer Joyce:
My associates, Peter Irwin and Steven Knhn, ret
with the information we requested. There may be enough for
analyses and we will lohk at them in the next few weeks.

Q14¢/

you for your information on DH—Szh. we
have begun our dose-finding and it is encouraging to know them the

I

want

to thank

clinical effects.
When I was seeking a PI 6208 in the New York area, 1"
celled California and was told that the machine was no longer made
nor eveilahle. I left my name, however, and received a cell on
June 1h from Jim Jordan, beon Electronics, (71h) 556-6500, saying
that he has located a PI 6208. If you are still looking for one,
or if you wish to reserve one in the event funds become available,
you may wish to give him a cell.
compound has

It

was fun

my

best regards.

from Oregon.

being with you, Iver, and our hypomenic

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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                    <text>June 17, l97h
John Stern, M. D.
Behavior Research Laboratory
Department of Psychology

Whehington University
1h20 Gretten Street

St. Louis, Missouri

6310h

Dear John:

I thank you for sending me the reprints which have kept
informed of your progress. Lest year I moved from the New York
Medical College to the Health Sciences Center, State university of
New York at Stony Brook, New York. A good friend of yours, Bernard
Tursky, is in the next building. We have had many pleasant dis—
me

cussions.

I look forward to being in St. Louis at the time of the
Neuroscience meetings in October, and perhaps we will have a chance
to discuss the many changes that have occurred in our science and
in Missouri since I left.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed

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                    <text>June 20, 197h
Robert Robinson, M.D.

A.H. Robins Co.

lhOT Cummings Drive

Richmond,

Virginia

Dear Dr. Robinson,

studies of

Enclosed is a draft copy of the initial dose-finding
2277 and haloperidol. Reflected in the extensive
the slow onset of activity of both these compounds

AHR

analyses is
in the doses

initially selected.

have completed the data collection in the
crossover study and the analyses are progressing rapidly. I
have tentatively set the target date for completion of the
statistical analyses as midpJuly and I should have a better
biew of the data then.
We

Again,

my

thanks for your cooperation.

Sincerely yours,

Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>June 21, l9Th
Donald B. Cheethem, Jr.
Smith Kline &amp; French Laboratories
1500 Spring Garden Street
Philadelphia, Pennsylvania 19101
Dear Don:

I am very grateful for a copy of the symposium report
on histamine receptor antagonists. While there is little evidence
in the volume on effects on the brain, I believe this type of work

will have special interest for us. I cannot believe that Nature
try to use the some tools in ell parts of the body.

would not

In addition to our continued

my enthusiasm for narcotic
much of my time these past seven

replaced

interest in

EEG, I have
(which
antagonists
occupied

so
years) with an interest in
the natural occurring peptides with central effects. For your
interest, I am enclosing two reports, one on EEG and one on pep—
tides, which may be of interest.
Again my thanks

histamine volume.
My

for your kindness in sending

me

the

best personal regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

�</text>
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                    <text>June Eh, 197h

William Guy, Ph.D.

The Georgo Wishington

Biometric Laboratory
11501 Huff Court
Konsington, Mhryland

Dear

University
20795

Bill:

packets.
garding

we

I

checked our

My

and did not find any green pediatric

still

waiting to hear from my Dutch colleagues reinterest in getting your advice.

am

their

files

best to

Ron.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

�</text>
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                    <text>uv-wrwv-w'

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wrewwlw

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i.

m’w‘r'w‘-v-&lt;

A

u.

~mnwwwlwrwrmmm

Abraham

Sudiloveky,

Clinical Research

Squibb

—

M. D.
CNS Team

Institute for Medical Research

Princeton.

J.

H.

085h0

Deer Abe:

(a,

smzmwv‘r

._

r—wn

'u«v¢

—-

:4
a

wj-v—wwrww—mrmmrvwmwvw,mmmuw-m—c

In discussions in Princeton with Dr. B. EtLr, which in~
cidentally I enjoyed very much, reference was mud to studies of
the peptides by scientists at Squibb using material obtained from

I have checked my references. and find a few publice—
1965
with deWied and two others with Upton and Lerner.
tiona
These seem to add
to our information on the central effects
S. Lande.
—-

little

of peptides.

enclosing a report I yrepered for the 197h ECDEU
meetings. I
grateful for any citations to published or
which
may augment this summery and my impressions
unpublished data
of the merit of these atuﬂies.‘ I.em particularly interested in the
studies at Squibb which were cited. and which may be in the public
domain. Would you care-to check with him and with Dr. Clody?

I

em

would be

many

thanks aha

my

best regards.
Sincerely yours,
Mex

Merd

Enclosure

Fink.

M.

D.r‘

Professor of Paychiatry
:‘

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                    <text>vmvwwc-

JUlY 9, 19Th

J. Khatin,

Abba

M.

D.

Veterans Administration Hospital
1601 Perdido Street

VP"

New

Orleans, Louisiana 701h6

7v"?!

Dear Abba:
urﬁmv‘r'wff‘

w;
'1'
w-u,

"(VW‘I

mew-r"

filing of the

I have received and will have

no difficulty with the
two protocols evaluating ACTH/NEH h~10 in schizo~

phrenice and retardetee.

toeol:

.

-'-,-v-

WWI-PW

a)

Copy

b)

A

I will need the following for each pro-

of the consent form.

small description (2 to h paragraphs)
of facilities at each hospital.

c) The

official

Columbus

Institute

name of the committees at
State Hospital and Coluﬁbue State

which

our protocol.
d)

will (or have) approved

Since Dr. Sandman is not on 24.13., it would
be most helpful if an M.D. at the Institu~
tion is cooperating in each protect. If
such be aveileble, we should have a short C.V.

I have Just called your office and find that you are
already on holiday and so I will probably see you in Utrecht before you receive this letter. I shall be able to file the necessary
supplement as soon a: the above information is available.
My

beet regards.
Sincerely yours,
Me: Pink,

MF:ed

cc:

M. D.

Professor of Peychietry

C. Sandman
H.

van Rieeen

nt—

�</text>
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              <elementText elementTextId="60133">
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                  <elementText elementTextId="106944">
                    <text>July 10,

197k

urn-my

Dr. P. Borenstein
Ldboratoire dc Paychopharmaeologie NeuroPhyaiologique
Hospital Paychlatrtque do Villojuif

5h, Avenue de

9&amp;800

France

la

Villejuif

‘

Republique
,

Dear Dr. Boronnteih,
by

is the abstract requested. I am not impressed
method to classify or identify drug effects.
Freeman's optimism, I do not think that thesc mothods

Enclosed

the ability at this

Despite Dr.

hava added much
My

ta our understanding of sleep.

hast regards.
Sindorely yours,
Fink. M. D.
Professor of Psychiatry
Mix

Mrzed

Enclosure

�</text>
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.

vrw—r-

mvn‘Wr-1"\Rn"mmm

mku—m—

mm

197”

Carl Sandman. Ph.D.

Veterans Administration Hospital
1601 Perdido

New

Street

Orleans. Louisiana 701h6

Deer Carl:

enclosing a copy of my letter to Abbe in the be—
lief that you will be able to supply me with the additional information that I need for filing of-theee two studies.

I

am

I am also taking the liberty of enclosing a c.v. of a
assistant, Steven Knhn, who has worked with me for one year.
He has been accepted to graduate studies in psychology at Ohio Stone
rand was one of the candidates that you interyiewed some months ego.
Should you be looking for a young and capable research assistant.
young

I

would recommend him
My

to you.

best regards.
Sincerely yours.
Fink, M. D.
Professor of Psychiatry
Mn:

Merd
Enclosures

.

�</text>
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                    <text>July 19,
‘Donald F. Klein,

M.

1971;

D.

LBJ/HMO

Department of Psychiatry
P. 0. Box 38

Glen Oaks
Kev York, N. Y.1100h
Dear Don:

I am indeed grateful fbr your work in setting up the
197h ABBA program, and see no objection to your wish to edit the
volume with Bob. Should there be any other contribution that I
may make, please do not hesitate to call on me;
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

HF:ed
2}
'\

i

go:

ix-

~|

'

A\\-.

\

R.

Spitzef,

3‘

‘

;‘ﬁcc:

J.

Zubin

M.D.

�</text>
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                    <text>July 19,
Dr.

J. Zuhin

New

York,

19TH

mY.&amp;uehmmnncmnume
722 What 168th
New

Street

York

Dear Joe:
As a follow—up to our discussion two weeks ago, I wrote
a short editorial for Joe Wbrtis and Biological Phyahiatry. I know
that such opinions are out of fashion now, but expressing them may-

nudge the pendulum slightly 3°° atamcmomy of psychiatric
A

copy

My

of

my

for move it
disorders.

must

if

ever

answer to Klein and Spitzer

we

are to

is enclosed.

regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd
Enclosure

�</text>
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                    <text>W

July 30, 197h
William P. Blakemore, M.D.
Sterling-Winthrop Research

Rensseleer,

New

York

Institute

Deer Dr. Blekemore,

studies of levo-cyolaaocine were undertaken at the New
York Medical College in 1971*1972. When I left the College in September,
1972 to my present appointment, the records of that-study, with the
date and responsibility for the other ongoing studies in opiate de—
pendence, were transferred to my successor, Richard Reeniek, M.D.
The

I have e study program in progress at the Drug Dependence
Treatment Center at the VAH- Horthport, and we ere exploring the

clinical efficacy of ealtrexone at this time.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>me—n ""erm
r

‘1’;

July 31, l97h
Samuel T. Robertson, III
3267 Queenstown Drive
Mt. Ranier, Maryland 20822
Dear Mr. Robertson,

Division of Biological Psychiatry of this Department is as
that it is relatively easy to describe the work in progress.
The senior faculty consists of myself, Joseph wortis, M.D., and
Harvey Karten, M.D. Other scientists contributing or collaborating with
our work are Bernard Tursky (Political Science), David Krikorian (Botany),
The

yet so new

and Michael Gazsaniga (Psychology),

to

‘
..

name a few.

work is in two directions—~ the measurement of
electrical signals from the scalp of man using digital computer methods
and correlating these changes with dose, type, and duration of action of
psychoactive substances, both therapeutic and those of abuse; and a
clinical study program evaluating the efficacy and safety of new
treatments for menttl illness under grants and contracts with NIMH
and NIDA. Dr. Whrtis is a specialist in developmental psychology
and the editor of Biological Psychiatry. Dr. Karten is a neuroanattmist
Most

of

my

tracing pathways in the brains of pigeons. Mr. Tursky is a psychophysiologist who is measuring bodily functions as predictors a!
attitudes and voting behavior. Prof. Krikorian is interested in the
botany of khat, another of the substances of presumed abuse, used in
East Africa, and which may be the subject of studies of its neurophysiology
and psychological effects. Prof. Gasssniga is known for his studies of
the split brain, and these issues continue to excite him and the students.
My laboratory consists of the usual neurophysiology
Hiinstruments and an IBM 1800 computer for the analyses. We recording
spend much
time with studies in volunteers, and usually have 2~3 fellows in residence.
Should you visit the campus, you may wish to visit the laboratonies. If
so, I suggest you call in advance ($16 hhh 2hh7).

Thank you
‘

for your inquiry.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.

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                    <text>July 31.

19Th

J. Grant, Ph.D.
University of Bridgeport
Connecticut, 06602

Michael

Dear Dr. Grant,

reply.

Your

letter to

Professor Stanley Yolles

was

sent to no for

1. The continued use of psychoactivo substances for‘
Itherapeutic purposes is to be expected, with an increase in use
as physicians find better agents and define therapeutic uses more

clearly.

'

2. Beteuse of the increased education of our community,
for greater controls in rcsearch and limitations on
reSearohers should continue, until an anticipated roaction sets
in, as research in the U.S. is sevorcly curtailed.
;

domandn

memory

.l'

thrusts for paychoactivc drugs seems to be in
enhancers, and compounds with high specificity, as in the

3. The new

studies of peptidos in relieving depression. Another mode: thrust
is in the development of delivery systcms for extended duration
of effects, to provide long-acting therapeutic agents with durations
of woeks to months. This is articularly true for narcotic antagonists.
antipsychotic agents, and tA leptics.
Quotation in whole or in part is not approved.
Sincerely yourc,

Max

Fink,

M.D.

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                    <text>nw-vW'wanvr:«Wm-.wu—vmmrnuvuwmrw

Stanley Yolles,
Max

Fink,

Renovation of

ww—

"a... .u-w-v

M.D.
Yné

New

Space

In preparation for the

in

Tower

for Neurophysiology

of the laboratories to the new
we must anticipate some improvements
in the spale assigned to the EEG laboratories and computer facility.
move

tower in the summer of 1975,
wv‘nn—vlo-

623: Computer

facility:

This will require an additional

electrical cable with special outlets to

'
"—7-“

requirements.

,..

Way-mm...

M.D.

nv"w:

_have

the

S—ton

meet the

1800

IBM

air handling must be arranged tor-- we already
air conditioning unit, but the plumbing and

The

electrical connections will be required. Flooring and cable
assemblies will have to be transferred from thedr present

location to the

new

building.

751: This area is to be divided into laboratory
which
reoms,
will require attention to air handling including
the installation of an air conditioner that We now have in Room
2323; separate electrical lines with special grounding; and
some soundproofing for the laboratory.
I600: Same as 751, except the number of spaces is

‘

greater.
_

V

.

these changes, is should anticipate both the
architectural and financial probllns. If possible, we should
set the steps in motion by asking Planning personnel to estimate 9'
the Jobs and outline the steps necessary; and on this basis, apply
to the Dean’ 8 office (or other appropriate agency) for the
funding and authorization for these modifications.,
To scoomplish

‘X

p

'

A

3

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                    <text>August 20, 197h

Fritz Freyhan,
2015 B Street,

M.D.
H.W.

Washington, D.C. 20009
Dear

Fritz,

honored and delighted to accept your invitation to
review the volume edited by Itil, Psychotropic Drugs and the Human
EEG". My only caveat is that I may not be able to limit myself to
the contents of the volume, since I know most of the Participants
and their work, and was consulted by Itil in the invitation list.
I do believe I can give the volume a professional review and am
willing to try, with the caveat that if you find the review unsatisfactory you may send it out to another reviewer.

I

am

If

you

feel that I

may

not be able to

do

the volume

reviewers, as Ernst
Justice, you may wish to consider other capable Joe
Tecce—~ these
Cole
Jon
or
Small,
Rodin, Janice Stevens, Joyce
about
issues and
the
knowledgeable
mind
on short notice as
come to

as dedicatld scientists.

Incidentally, have you considered a review of the volume
"Psychobiology of Convulsive Therapy" which I edited with Kety,
McGaugh and Williams ? I do hope you have asked that it be done,
for CP is probably the main Journal that can do the volume Justice.
En another matter, you will receive a call later this week
or the week after from a Dr. Markus Gastpar, a student and faculty
member of the hospital in Basle with Paul Kielhols. He has been in
my

laboratory for a

September.

Thank you

month and wished

for thinking of

to visit washington early in

me. My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Septeﬁber 13. 197k

Alfred Freedman,

D.Cheirmen. Department of Psychiatry
New York Medical College
106th Street and Fifth Avenue

New

M.

York, N. Y. 10029

Dear Al:

I

am

Enclosed

is

pleased to acne

a complimentery copy of the EST volume.
to you with gratitude IOr your support

it

interest in this project. I regret the delay in getting it
to you, but I was confident that it had been sent as part of the
original mailing.
and

I have received a request for a

copy from the APA
museum, which I an honoring at this time. If you have any clout
with the APA Hewsletter, perhaps they would recognize the publication of this volume under their new books published, especially
if an appropriate description could he added.
My

thanks.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

HF:ed

Enclosed

�</text>
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                    <text>September 3.

tor~1n~Chier

;

72015.12.

Street, a.

‘wﬂhimon,

D. C.

197!»

w.

20009

Dcnr?Pr1tz:

It was my undgrstanding that a rcvicw copy was sent
}' Ceuprehcnsive Paychiatry. Eovevur. rather than trsck it down,t9I
enclosing a copy fbr this purpose.
'

‘

,,

Thank you
My

fbr your interest._

best regnrds.
Sincerely yours,
Fink, H. D.
Proteasor of Psychiatry

Mb:

am

�</text>
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SepteMber 18, 197h
a".

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mm

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Joseph Meites, M. D.
President, Endocrine Society
Department of Physiology and Pharmacology

State University
East Lansing, Michigan h8900
Michigan

Dear Dr. Neites:

I am writing at the suggestion of Dr. Dorothy Krieger.
During the past year, I have become interested in the cerebral
effects of hormones, particularly derived from ACTH. My experience
with hormones is limited to my education in medical school some years
ago, and I inquired of her as to the availability of post~graduate
courses in endocrinology (particularly neuroendocrinology). She
knev of none, but suggested that I write to you first, as a matter
of inquiry, and second, to suggest that there may be others like my—
self interested in such an opportunity.
I

would be

grateful fer your advice.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

cc:

Dorothy Krieger,

M.

D.

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                    <text>SepteMber 13, 197h

William G. Clark, Ph.D., Chief
Veterans Administration Hospital
Psychopharmacology Research Ldboratory
Sepulveda, California 913h3
Dear

Bill:

Enclosed are the references which you requested for the
updating of your volume.
former

I regret the delay, but your letter was sent to
Institution and took some time in getting here.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

Enclosure

'

my

�</text>
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                    <text>.
:v-r 'v-q—vr

"W“vw"

”"mem

m

September 13, 197h

Siva Sankor, Ph.D.

Queens Children’s Hospital

7&amp;903 Commonwealth Boulevard
Bellerose, New York llh26

Dear Dr. Sankar:

I regret the delay in answering your letter of

but it was sent to
yesterday.

my

former University and

August 20,

I only received

it

I thank you for the invitation to contribute to the volume
on "Psychopharmacology in Childhood”. I regret, however, that I have
little original data that I would consider for submission in such a
volume. However, my former associate, Jovan Simeon, of the Missouri

Institute of Psychiatry, has had extensive experience in this field.
I would suggest that you write to him should you wish another
participant in your volume.
My

best regards.
Sincerely yours,
V

Fink, M. D.
Protessor of Psychiatry

Max

MF:ed

4

.

�</text>
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                    <text>:
e

E

i
I

September 16, 197h

F

George Serban,

M.

D.

Kittay Scientific Foundation

hSO
New

Park AVenue
York, N. Y.

10022

Dear Dr. Serban:
Thank you very much for you kind invitation to attend the
presentation meetings of the Kittey Foundation honoring Professors
Cede and Schou. It should indeed be a memorable occasion, and I
regret very much thatFI will be unable to attend as I will be
attending a meeting of the Psychiatric Research Society in St. Louis.

It was kind of you to think of me

the meeting.

and I wish you success in

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

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                    <text>September 2h, 197h

Mr. Berton Roueehe
The New Yorker
2h west h3rd Street
New York, N. Y.

Dear Mr. gouache:

are sure to write about your article, "As Empty as Eve”,
to sympathise with Mrs. Parker and to praise your presentation. Some
will write to criticize the errors of fact and of experience. I am
writing to express my sadness that you have chosen the public press
to air a single medical case report, without the leavening of
clinical experience, which would permit this case to he ’eeen in the
context of the goals, successess and failures of this therapy. I do
not understand what service you uere attempting to offer, but surely you
.ghaVe added.your powerful voice to the many who fear that vh1ch they do
I_not Understand, thus making_it more difficult for patient 5 Who may be
helped to receive treatment.- YQn are encouraging many patients to
I.veehs and months of the unnecessary hell of a severe depression; and
even some to a suicide that may have been prevented.
Many

_

‘

'

I am sad that the New Yorker and particularly you. with your
a.record of fine writing, have choSen this topic to attack.. It is easy
easy to damn
"to find the single case which hes not done veil; it
'vith innuendo, error, misquotation, and selective quotation,balance
it is hard
to stay one' a voice when we are ignorant, and to speak with
~

is

V

when we have an urge

to speak.

Some specifics. Free the record given, it is probable that
_.
curs. Parker was a poor choice for this therapy. I anticipate that she
is a person who is critical in her perception of her environment —- in
:.psychological terns, she has a low California F-Scale, makes few errors
c;on figure-ground tests, and is unusually accurate in the perception of
*the visual upright. Such individuals, when they become depressed, do
so gradually, and characterize their depression not in mood or affective
terms, but in body symptoms (often termed hypochondriacal) and are
,

:

'

,

�Page 2

Berton Rousche

September 2h, 197h

generally poor therapeutic risks. The outcome you describe with convulsive therapy is rate, since patients who have her background are
infrequently treated with this therapy. One of the limitations in
getting therapists to have adequate experience with convulsive therapy
is the prevailing social attitude that the therapy has less success
than the psychotherapies, that it is less elegant, and that it repre—
sents (in some minds) a failure of a 'better' therapy. Indeed, one
would guess that the consulting psychiatrist was reluctant to recommend
Regr tfully, had he chosen a form of
this candidate for this therapy.convulsign
there " in which the appli—
the therapy called "unilateral
cation of the electrodes is not to both temple, but to the scalp overlying the non—dominant cerebral hemisphere, the complaints would
surely have been less, for this therapy yields allmet equivalent therapeutic change with decreased effects on memory and recall.
There are also many errors of fact. The historical origins
of convulsive therapy are not usually related to the experiences of
Reil, but rather to the interest aroused in the biological causes of
insanity by the successful treatment of general paresis by fever
therapy by Wagner von Jsuregg. This observation was universally
hailed as a step forward in the treatment of the insane (yon Jsuregg
receiyed the Nobel Prize for medicine for this obserVatioh) and led
many scientists in Europe to-seek other biological rays to relieve the
symptOms of the mentally ill.- Convulsive therapy is usually described
as originating in the lehdrstories of the Hungarian, Ladislas von Meduna,
who Observed that schizophrenia was rare among epileptics and that
;-epilepsy was rune among those with schizophrenia. Seeking_a way to
'rnlieve the plight of severe psynhotics, he tried to simulate epilepsy
hy'intrayenous administrations tirst of camphor, then of pentelenetetrasol
"(Metrszole). The first-patients improved markedly and it was following
his early reports that the Italians, Cerletti and Bini, tried electrical
itinductions of seizures.

»1

,

;

,

Electro—eonvulsive therapy has gone through many'modifications
‘hin the past 38 years. The techniques of administration have improved
(succinylcholine is the latest of the muscle relaxants; the use of a
gﬂ-sedstive, usually Brevital, is not to improve breathing, but to pro-

vide relaxation for the patient before treatment and to-reduce the
excitement which occasionally is seen after a seizure, unilateral
seisures and flurothyl seizures are used in selected cases, etc.).
‘iOur understanding has gone from ideas that the treatment is a punish—
nent for sins, or to frighten the patient to health, through the stage
where the therapy was related to amnesia, to present views uhich ascribe

“K\\\
\

�Berton Roueche

September 2“. l97h

Page 3

to the biochemical hhenges which result from the seizures.
Indeed, the therapy is seen to produce long—lasting biochemical changes
in the central nervous system which are remedial to depressive mood
and psychotic idention, in appropriately selected patients.
improvement

carp about a few specific errors. Insulin come therapy is
not in widespread use. For example, there is no insulin coma therapy
unit in a community hospital in New York. It is far from the inspiretionsl prototype of electroconvulsive therapy since Sahel clearly separ~'
sted insulin come from the convulsive therapies, as did many of his
followers.
To

ECT

cemphor were used

I

first

was not the

earlier.

convulsive therapy - metrezole and

surprised by the quotations from Noyes end Kalb, Hope and
Adams, and Aubrey Lewis for none of these authors have written on the
subject within the past two decades. The quotations from Squires end
Ottosson are appropriate. Ottosson is one of the most experienced
observers of convulsive therapy and it may have served him better to
quote from his more recent studies, and those of his co—VDrkers,
Lsurell and d'Elis, then to use an older study. Squires is a young
am

who hes done only one experiment.
The gho—
"New
Home
from
Medical
Encyclopedia" is probably accurate.’
the
tstion
but one would wonder why you have selected this lsy volume as an

experimental psychologist

authority to quote in the

New

Yorker.

In sun, I em disappointed that the New Yorker, known and read
for its accuracy and fine reporting, sew fit to publish a single case
report, with many errors of feet in discussion therebydoing e dis~
service to the many patients uho‘will undoubtedly read or be given
this article, Ind who will be scored out of their wits if a physician
recommends this therapy. The harm that has been done will never be
known by you, but the many therapists who will find it more difficult
to use this therapy when it is useful will have reason to remember
you, as will the families that will have lost a member by suicide..
—

A

Should you wish to reach other scientists who may find your
report a disservice, I suggest you call Dr. martin Kata, head or the
Clinical Research Branch of the National Institute of Nentel Health,
or such concultants to the NIMH as Dr. Seymour Katy, Harvard Medical

School, Dr. Lather Knlinovsky of the New York Medical College, or
Dr. Charles Shegsss, of Temple University (also this year' s President
of the Society of Biological Psychiatry and the American Psychopatho-

logicsl Association).

‘

�Berton Roueche

Page h

You may

Septuﬂber 2h, 197h

also vish to read some of the more recent volumes
to assist you, I am appending citationa that are

on the subject. and
well known.

Lastly. I would suggest that you spend a week studying a ward
of chronic mentally 111 (in any State mental hospital) and a week visiting laboratorics renoarching the nawnr tharnpiea of tho_mantally ill.
Perhaps than you may be able to write a more balancoaroaponse to your~

self.

‘

Sincercly yours,
Fink, M. D.
Professor of Psychiatry

Max

Mrzed

cc:

Peter F. Fleischmann, President

The New Yorker Magazine,

Inc.

Kalinowsky, L. and Hippius, H. Pharmacological, Cbnvulsive and ether
Sbmatia freatmunts

in Phyahiatry,

N.

Y., Grune and Stratten,
'

1969.

Fink, M., Katy,

8.,

EcGaugh,

Cbnvulaivc Therapy,

Fink.

M.

J.

and Williams

T., Pbyahobiology qf

Whahington; V. H. Winston and Son, 19TH.

Convulsive Therapy, Saminara

in Phyahiatry, 1g; 1972.

/

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.-.H~.,v

w ,m. u...“ ,.

..,......, i.-.

w."

.,,

.

,7

W

,

_,

SePtem'ber 25, 197k

Jack F. Wilder, M.D.
Chairman, Department of Psychiatry
Albert Einstein College of Medicien
Bronx, New York
Dear Dr. Wilder,

I am writing in support of the recommendation for promotbon
William
Karliner, M.D. to Associate Clinical Professor of Psychiatry.
of

Bill Karliner since 19h9, when I was a resident
at Montefiore hospital and he was a young attending physician. Over the
intervening years, I have had occasion to refer patients to his care,
and to follow his studies of somatic therapies with interest.
I

have known

In 1967 1971, I was responsible for a systematic study of
in patients at
unilateral and multiple monitored convulsive therapy recommendation
of
We
the
on
dependent
were
Gracie
Hospital.
Square
the
the practitioners of their patients for our studies, as well as their
willingness to cooperate and to achieve the cooperation of their
and
patients for extensive studies of EEG, psychological tests, be
among
follow—up studies. Throughout the period, we feund Bill to
data
the
by
we
and
were
regarded
the
of
most
staff,
cooperative
the
which we eventually published in the scientific press.
—

In these associations I have feund Dr. Karliner to be an
enthusiastic clinician with dedication and patience, a keen research
enthusiasm, and capable of relating well to patients, staff, and re—

searchers. His fine reputation

known

to you.
I

am

among

the clinical community

is well

pleased to endorse a recommendation for promotion.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>74$B~08888
1 Mhrch

M

E

M

0

1974

R A H D U M

To:

Horvin Knachnor. M.D., Boon, school of Modioioo

From:

Max

Fink, M.D., Professor of Psychiatry

Subject:

VAR

Northport

In your discussions with the faculty of the Department of
Psychiatry some weak: ago, you highlighted the importance of
the facilities at VAR Northport and our rolationohip to that
hospital for the dovolopmoot of this school.
The following capsular history may be holpful in your
tiouing negotiations with that institution.

con»

In tho spring of 1972, Dr. Yolles and I obtained support
from the VA Control Offioo for the catnblishmont of a drug do~
pondonoo treatment center. Like Venus rising from the sea, the
unit was established on July 1, 1972. By October, 1972, the
ward was staffed; mothadono maintenanoo. narcotic antagonists,
and detoxification for opiate dependence wore all provided by
a staff that had been wall trained; and additional funds had
been awarded by NINE for those programs.
By

tho tumour of 1973. Hard 663 had boon renovated and a

fine facility established.

'

During that same cannot. we notod that the number of opiatedcpondont subjects in the community had boon reduced (part of a
national phonomonon), and we discussed with Dr. LoCerva the cd~
mission of patients with alcoholism in that unit. Approval was
granted, and since September 1973, we have run a census of 75%
alcohol abuso pationto and 25% opiate-dopcndont.
”1"

�W

”2-

W1
March 1974

Last July, we became participants in the national
loborativo Study of Lovonothadyl and Mothadone.

VAH

Col~

This program has continued to develop until Wednesday,
February 27, when Dr. Briasondon and I wore peromptorily noti—
fied by the new modicnl director that the funding for this unit
would terminate on June 30, 1974, and that wo should not ac-

cordingly.

Aftor considerable discussion with the

new medical

director,

I boliovn that on were able to convince him that, althOugh tho
discontinuation of this unit is feasible and can be accomplished
readily, a two-year investment giving life to it was worthy of
some discussion. Ho agreed and ousgostod that ho would roviow
the programs in Washington.

like to indicate that we wont through a similar
tho
curtailment of funds in l973. and on wore able
in
crisis
Whohington to our satisfaction.
intorvono
in
to
I

would

In our discussions some weeks ago, you aokod for any information which might onhanoo out rolationnhipa with the VA.
Thooo ovonts nova been distressing, to any the least, and
while maintononco of this unit for some additional months is
highly likely, I wonder if this capsular history does not reflect
the lack of a significant portnorohip between the VAR and the
Mbdicnl School. If Northport is indeed a Dean's Hospital, should
not the creation or destruction of programs be a matter of con~
corn to the Bonn? In it proper, in your conception, for pro~
grams to be amputated without discussion of their significance
to the touching and research programs, as well as tho treatmont
of patients?

Fortunately, Dr. Yolloo anticipated the sequence of ovonto
and has provided the Department with alternate teaching and
research facilities at another institution. Perhaps you will

understand now why this faculty encouraged this relationship
will continua to do so until hotter faith is shown by the
VAR Northport.
and

NF/cio

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                    <text>7488-08788
1

M

E

0

M

March 1974

R A N D U H

To:

Marvin Kuschner, M.D., Dean, School of Medicine

From:

Max

Subject:

ADA

Fink, M.D., Professor of Psychiatry

appropriate, if it has not already been done,
for the School of Medicine to establish an AOA section. ADA
has been used as an incentive for excellence in study in other
institutions and may be useful here as well.

It

may

be

If not yet established, perhaps your office could inquire
of the faculty how many are already members to determine if a
sufficient nucleus exists for the development of such a unit.

MF/cis

IIIIHIIAL‘

�</text>
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                    <text>m

ermam'-.—.w_—m.w
v

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vvwrn—enw‘w...

WW

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,

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n“ 1-.

_

_

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w.

w

March 2, 19Th

”'m'ﬂ’www‘rprwuvqam.

E
E
'5

Philip

Bookmsn, M.D.
Hermann LsRoche, Inc.

Rutley,

New

Jersey

E

§
E
y

Dear

Phil,

3?

¥

I very much enjoyed our discussions on Thursday, and I
thank you for the invitation. The final report on thebe diszepnmcompleted
bromszepam-plscebo EEG and bloodllevel study should
the end of the mbnth and sent to you.

by

In checking my files, I found the enclosed report by Dr.
This report answers some of the questions raised about the
Itil.
evaluation of thymoleptics and antidepressants by neurophysiologic
methods. I spoke to him and he was pleased to have me send you this
copy for your information.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

�</text>
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                    <text>:ercuﬂf‘mﬁllz;

av

«‘Mﬂl'lgﬂﬂn‘ﬁ‘w

wwwﬁw—wvzmmmrwr

15¢?“er

“vi/3r

Irvww

7458-09083
4 March 197é
Edward

J. Callahan,

Ph.D.

Research Specialist and

Assistant Clinical Professor
of Psychiatry

U.C.L.A. School of Msdicins

Csmstillo~ﬁouropsychiatrio Instituts
Rosssrch ?rogrsm

Box 'A'

Camorillo, California 93010
Dear Dr. Callahan:
Thank you for your invitation to participate in your
research program. I have read your project proposal and it is
indosd interesting. I would be delighted to serve as s con~

sultant.

I so enclosing a recent

summary by Wiklsr which may augment

your formulation, as wall as a copy of

my

vita. as

you requested.

Sincerely yours,
kink, M.D.
Professor of Psychiatry

Max

Wlois
Encls.

�</text>
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                  <elementText elementTextId="106932">
                    <text>'Jr—lz-"rm ww—

WV”: ’-.'

,_.__
.,v- - r,

W ,m '1, wm‘“

-V

'nrv-‘J‘4'Y: no;

,
.... “r..."w" _,,_,~_,._,
.

.

H.

.. ,. "ﬁt-rm

,

V

mn— ..

,

“("4

n. u.

,y. 3.7-.-....;.7—w

.,

«v

‘—

q

.1

-

c

7.

,.

7483—09183

5

March 1975

Richard Rnsnick. M.D.
Department of Psychiatry
New York Medical College

East 102nd Street
Now'York. Now York 10029
5

Dear Richard:

I am pleased to confirm the arrangomont whereby tapes con~
taining EEG information collected at tho New York Modical College
laboratories can be processed at the computer facilities of

Stony Brook. The programs which we dovelopod at the New York
Modicsl College are available, and VB will be pleased to assist
in the program,
you in the analysis of the data to be collgctod
"
"Studies of Cocaine in Man."
my

best regards,
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis
cc: I. B. Schwartz

‘I‘

�</text>
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                    <text>_...

March 12, lQTh

'v-vvv-vv

V's-Irv

"v—IW'

nwwwu

m

‘I-w-I

-‘..m~.—wv.m

Robert hunt, M.D.
Massachusetts Mental Health Center
7h Fenwood Road

Boston, Massachusetts 02115
Dear Dr. hunt,

Enclosed are two recent summaries of the work which is
currently under study in my laboratory. The xerox copy of the galley
proof is a report in press that I completed in January, 1973; the
preprint a capy of an address that I made in Holland in October,
at a convocation reviewing the recent progress in developing new
drugs, particularly the development of mianserin (GB‘9h). .There
is some redundance in the two reports, occasioned by the different
audiences, but these will give you some idea of the problem.

It is

my

intention to develop a collaborative program,

bringing together the chemistry and pharmacology of industry; and
the interest and enthusiasm of the university. The focus will be
in the ebaluation of new compounds for psychiatric purposes, as well
as refining the methods of this evaluation.
While much of our work

pharmacology,

we

is dedicated to clinical psychointerests to studies of

have applied these same

convulsive therapy, cannabis, opiates, and Opiate antagonists.

March 23.

I look forward to discussing the program with

you on

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

a copy of your curriculum vitae.
reimburse you for the expenses of the visit.)

P.S. Please send

me

(We

will

�</text>
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                    <text>STATE UNIVERSITY

or

NEW YORK AT STONY BROOK

HEALTH SCIENCES CENTER
School of Medicine

'1

Stony Brook, N. Y. 11790
Phone: 516-444-2413

Department of Psychiatry
13 March 1974
Mr. Stewart Alsop
Newsweek
444 Madison Avenue
New

York,

New

York 10022

Dear Mr. Alsop:

conclusions regarding the use of opiates in dying pa—
tients, quoted in the New York Times of March 5, strikes a res—
ponsive chord. I am a national consultant in opiate research
with experience in studies of heroin, and I am frequently called
upon to answer disturbing questions.
The

Physicians ask whether heroin may be used, its safety, and
their risks are with regard to the Federal Internal Revenue
Service and the Bureau of Narcotics and Dangerous Drugs. I have
to answer that they may not use heroin; that even for research
obtain permission and supplies; and that their
it is difficult toBNDD
IRS
and
fears of
are probably groundless. But I am not sure
about the latter statements, recognizing that in their asking,
the physicians are reflecting a fear that may be founded on

what

history.

Because experience with opiates is limited, they tend to
use dosages that are too small for fear of developing 'dependenee,‘
thereby under—treating their patients. This attitude reflects on
our education and on the proscriptions quoted in our journals.

I have used heroin to treat relentless pain and have found
it is quicker in action, more effective in response, and
has fewer side—effects than morphine. As you have suggested,
the mood—altering qualities are particularly gratifying.

that

Your reference to morphine and heroin brings to mind the

reports that other opioids, particularly etorphine (M-99) have
been tested and are even more effective than heroin; that they
are probably 1000 times more active on a dose basis~—but studies
-1-

�Mr. S. Alsop

13

—2—

March 1974

w‘

.

aha-vat.

are proscribed by authorities in the U.S. and Europe for fear

that the

Afor man.

it

'instantly addicting' and too dangerous
Its use is limited to animals, where (as Immobilon)

compound may be

is used to capture non—feline mammals. (For a description
of its use in patients, see the reports by Blane in Agonist and
Antagonist Actions of Narcotic Analgesic Drugs, Ed. by H. Koster—

litz.

London:

Macmillan, 1972.)

Not only should heroin and etorphine be made available for
found useful, allowed to be
prescribed by physicians for patients with intractable pain;
but we should be willing to make these substances available to
patients with instructions as to the consequences of‘overdose,
so that they haVe an opportunity to self-regulate their dosages
as needed.

clinical analgesic studies and, if

Your

efforts at liberating these analgesics for medical

uses are to be encouraged.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF/cis

�</text>
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                  <elementText elementTextId="106929">
                    <text>“7‘ &lt;—-,-.-

.W,

.‘V,, ,,, I.”

My“. "an” yum-m u

Mmmmmwm

spur]... &gt;1,"

”at—www—L‘

-w :ﬁm'luw" mun w ’IWWWWm-qu—rrltx‘

a». ur.’“vw-v~:.a

um uvr

V.-. -'-'-3V.'"~'.-'wunu

m—m—vmmmmw

\

*FE'a'WurAi‘v-‘W
'

-ww.

_

All-“_4|

lﬁ Hatch 1974

SW: Katy.

MOD.

Protaucor of Psychiatry
Harvard Mndienl schaol
Massachuaoten Ganortl Hospital
Yruit street
-Boocon. Natanchunctts 02114
Dan: soynour:

Bolton oa.uians of tho Anarican ?tyehopatholoslea1 Association.
Yam

chnuld ouch rucnivu five c0911: an algtor~cantributorn.

I an analouin; nous cards for distribution, should
m.fnlo

yum

find

chwaa

I

I an plugged with tho volunn, and‘I hop. yea arc altos I an
grataful for your collocttvu and individual advice, attainina,
and contributionl-und*¢an enly say "Thank you."'
My

bCIE

regards.
Sinnartly youri,
MIX

MF/ais
Enﬁlo

'6: 3m- Mﬁmm,
Thomas A.

211.5.

Williamt. H.D.

ﬂﬂk .‘ ”uni

�</text>
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