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                    <text>March 19, 1977
Mr. Robert Lyons
York Academy
2 Est 63 Street

New

New

of Sciences

York City

Dear Mr. Lyons,

I have received a large number of reprint requests
inquiries regarding the purchase of the volume 282 on
Chronic ﬂannabis Use. I am writing to ask whether the Academy has
printed descriptions and purchase order blanks for this volume. If
yes, I would appreciate about no copies. These will be sent to the
requesters with the reprints that are available.
and

Parenthetically, I recall that our agreement

the editors would receive
3 copies.

5

was

that

copies of the volume. I have received

I hope the volume is well received. From the reprint requests
already in hand, I would say that the interest is quite high.
Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

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                    <text>x
law

a»

40"me

:nnsvznr

w—r

~,

Inna-w-

wy...

‘I'“(“'.

w“.- ._,..,.,,W.,~r.

vlvu/anH.

-.,

‘nﬂV‘Lvr‘r'vvv ”H... a.

,

,

.

.

.,,

.,_.,,.,....~a.

n.—

.mmw—l-w n»,

_.

3;.

:‘x-i

'1'.“er

{mtgyr‘rw'v r.7v..lr'-"t:\1vw. w.

April

ll,

v'uﬁrh‘avv‘n""!v~n'v~m:

nay-aw

,-

.

-

«

,

.

1977

Dr. Francis C. Colpaert

Jannsen Pharmaceutica

Beerse, Belgium

B-23H0

Dear Dr. Colpaert,

It has been a number of years since I was directly
involved in studies of narcotics and narcotic antagonists, so that
your questions came as somewhat of a surprise. Nevertheless, I
shall try to answer as best as I can.
subjects repeated doses of heroin
that we did not observe
tolerance. When we gave oral doses of methadone, tolerance developed
rapidly, and when we gave such subjects injections of heroin, we
were able to observe cross—tolerance. Depending on time after
oral dose of methadone and dine, subjects either could or could
not distinguish placebo from heroin. They generally used as
cues their subjective feelings of relaxation ("high") plus the
change in skin tingling, respiratory slowing and occasionally
the relief of irritability. When we gave patients levomethadyl,
they developed tolerance as they ddd to methadone, and the same
pattern of cross tolerance to heroin, with a different time course.
When patients who are tolerant are given a single dose of naloxone
or cyclazocine, a severe withdrawal syndrome is precipitated. These
are the types of experiments we carried out, and based on these
observations I would think the answers to your questions are as
When we

gave

intravenously, the timing

was so spaced

follows.

1. The discimination of a narcotic from a placebo

is dependent on dose of the narcotic, state of the subject (tolerant
or 'clean’), and time in the withdrawal period that the narcotic
is given. If repeated administration is rapid (doses within a few
hours of each other, as in three or four times a day) then tolerance
is seen easily.
2. Users discriminate

active

from

inactibe material

their central effects mainly: relaxation, euphoria, drowsiness,
decreased irritability; and to a lesser extent from peripheral cues.
from

also use the relief of withdrawal symptoms
allowed to devlop.

They

if

these have been

m

-

t.»

H" -w-

w;

.—

mn. v.

~

_..--

�q;

(an.

-

-Wm—_~&lt;

-

Dr.

colpaert 0000000000000mch11’1977 000.000.000.000 page2

to tolerance.

3. The euphoric

I

trust these

effects of opiates are subject

comments

are helpful.

Some

years

ago, 1970 or 1988, I visited Beerse seeking some undeveloped narcotic
antagonists as werwere then hoping to find an improvement on

cyclazocine. I remember with pleasure the cooperation of the
laboratory personnel, and I am pleased that your work has continued.

My work at the New York Medical College continues
under the leadership of the chairman of the Department, Professor
Alfred M. Freedman. Should you wish some additional information

regarding their recent experience with heroin, naltrexone, etc.
you may wish to write to him.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>April 13, 1977
William
The
#89

J. Darby,

24.13.,

Nutrition Foundation
Fifth Avenue

New York

Ph.D.

City

Dear Dr. Darby,

I want to thank you for sending me the many reprints
describing the studies of the influence of food additives on nehavior.
These have been helpful, and at present I am working through a number
of suggestions for a protocol for the study of chomolyn sodium in
hyperkinesis. I have the agreement of the clinic at Hillside Hospital
to undertake such a study this summer, and we have obtained some
encouragement from Fisons Ltd.

Should something come of the project, I shall
Again,

my

let

you know.

thanks for your help.
Sincerely yours,
Max

Pink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>rump-Fwy.

:wWWTm"

nnl'wv‘rz'rw‘umr

.

_

.

wwwrmv-mmmrw—survWat's; 31"!- --v Wmmuwm—mv‘

V

.i

April 13, 1977
Dr. Thalia Harmony
Habana, Cuba
Dear Dr. Harmony,
Than you

for your interesting reprints

regarding the citation in the

CHAN

volume.

and the question
I note from your papers

that E. Roy John has been one of your preceptors. In the CHAN
discussion, I was citing the many advances in this country in the
development of special computers for diagnosis (the work of Harner,
for example); the use of averaged evpked potentials for the identification
of brain damage (here the work of John is a fine example); and the
use of cross correlators (the work of John is still the best example).
In the latter reference I was also interested in the studies by Leonide
Goldstein. There are surely others but they do not come to mind
readily, although I recall similar interests by the school at the
UCLA Brain Research Institute (Adeyyand his co—workers).
.

i
'

is far

studies
reflected in your studies. We emphasize the application of the EEG
to the definition of drug effects-- a good example is the paper in
My

work

from the basic neurological

the CHAN and that of my former co-worker, T. Itil.
question regarding that study, please write again.

If

you have some

.Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>STATE UNIVERSITY OF Nii'W YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

3I
Q

Department of Psychiatry and Behavioral Science
Psychopharmacology

——

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

April 27,

Michael Natale, Ph.D.
College of Physicians

Columbia University
722 West 168th Street
New York, N.Y. 10032

&amp;

1977‘

Surgeons

Dear Dr. Natale:

scientist who may become interested in
Dr. DiBianco at Misericordia Hospital.
is
linguistics
The only

has applied for an NIMH grant to study behavior changes
in patients undergoing hemodialysis. I sent him to Dr.
Jaffe for advice.

He

You may wish to contact Dr. Joseph Mendels at the
in Philadelphia. He is a biological psychiatrist with
wide ranging interests in novel methodologies.
Good

VA

luck.

‘Sincerely,
Fink, M.D.
Professor of Psychiatry

Max

MF:fg

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                    <text>or may YORK AT STONY BROOK
Health Sciences Center - School of Medicine
STATE UNIVERSITY

3’

3

’

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

April 27, 19773,

Bernardo Heller,

M.D.

2323 Van Buren Street
Apt. 201
Hollywood, Florida 33020
Dear Dr. Heller:
and

Institute

The

it

now

opened the ward L6 in the

has 10 patients in three studies.

fall of

1976
Dr. Asnis is

the ward chief, and Dr. Ts'o will be the other staff person
in July. As you may have read, N. Y. State did not allow
any new positions for LIRI for 1977-78; and so, regretfully,
I cannot process your re—application at this time.

It

training

would be best for you to complete your residency
and meet the requirements for licensure in Florida,

try to-re—establish your research studies.
Best wishes in your studies. I trust I will have

and then

chance to see you at one of the national meetings.

a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszg

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

4/,

5

I)cpurnncntofPsychhnryinuchhavknalSdencc
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phonc25164®hL2447

.

.

April 27,

1977

Committee on Awards, Grants in Aid of Research
Sigma Xi National Headquarters
345 Whitney Avenue

New

Haven, Connecticut, 065ll

Gentlemen:

like to endorse the application of Mr. Jay Schneider
of the effects of ACTH 4—10 on the EEG and DC
recording characteristics in monkeys. I have known Mr. Schneider for
half a year, as he has been associated with Dr. John Stamm and Mr.
Oliver Gillespie in their studies of ACTH H-lO.
Mr. Schneider will graduate from the State University of New
York at Stony Brook in June, and is matriculated as a graduate student
in psychology at this University for September, 1977. During the past
year he has been an active collaborator in the studies of ACTH #10 and
he proposes to continue these studies next year.
His interest in the problem has been stimulated by Mr. Gillespie,
his
by
rand
readings. I have been a consultant to the project and in the
late fall, I invited Dr. Henk van Riezen of Oss, Holland to visit the
project at the University. The meeting was fruitful fOr it clarified the
direction of the research and the present work is an outgrowth of that
I should

for support of

.

session.

a study

'

studies of the effects of peptides on memory and brain
functions are derived from the work of David de Wied of the University
of Utrecht. I have been doing some of the human assays in my laboratory
and stimulated the present efforts by Stamm and his colleagues. The
significance of the work is well defined: the effects of ACTH 4—10 seem
to prevent the extinction of a learned response. It provides an interesting
opportunity for clinical studies in patients with memory deficits due to
aging and as a result of electroconvulsive therapy. We are pursuing both
leads clinically. The work proposed here should provide a neurophysiologic
underpinning for the clinical studies.
Mr. Schneider is working in a well equipped laboratory under
experienced and competent direction. The funds requested will permit the
present efforts to continue; to expand the measurements of changes
induced in the EEG and in DC recordings from brain areas not studied
well before, the prefrontal and infratemporal cortex. In the rapidly
expanding field of peptide studies, I think that these exercises at this
University will be most.helpful in understanding the effects of these
substances on brain functions.
The

Sincerely yours,

7L.»

Max

J’W

Fink,

M.D.

Professor of Psychiatry

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                    <text>AMHV

moor 2M7

May 129

John Donnelly,

1977

M.D.

Institute for Living

200

Retreat Avenue

Hartford, Connecticut 06102'
Dear John,

I am writing to request a copy of your presentation on
the status of psychosurgery, as presented to the APA in Toronto. In
addition, would it be possible to obtain a copy of the recommendations
of your task force on paychoeurgery ?
I am preparing a paper on the advances in the organic
treatments in schizophrenic for Lee Bellak and I would like to
cite your experiences.
Many

thanks and

my

best regards.

nm-uwmwwr-

.
.
am"

Sincerely yours,

Fink. M.D.
Professor of Psychiatry
Mex

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            <elementTextContainer>
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            <elementTextContainer>
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                  <elementText elementTextId="107011">
                    <text>May

Gabriel Laury,

Box A

13, 1977

M.D.

Kings Park, New York
Dear

&lt;&lt;

.
.,

l
w

A.

-..v

‘VE'H'D'HVJJIwn-ffvgg

Gabriel,

I am embarrassed to put you to this difficulty. I
did apply for the transfer in 1975. and then promptly forgot.
Once, a member of the Suffolk Branch called to ask the reason for
my transfer, and I explained that I no longer participated in the

New

York

District Branch affairs, and that I wished to attend some
now that my principal site

of the sessions organized in Suffolk,
of work was the University.
I never heard

inn-7.“.

from the Suffolk branch

after that.

,

:-

.

the

&lt;A

w

New

Recently, I

was reminded

that I was still a member of
I resigned two years ago.

York branchu- a membership which

,
.mr»

.w

-::

'r-rux"

If there is some problem in accepting this transfer
application, please let me know.

lair—1‘1"

mnw.~m&gt;nx¢w—u

Sincerely yours,
Max Fink. M.D.
Professor of Psychiatry

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              <elementText elementTextId="61793">
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          </element>
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                <elementTextContainer>
                  <elementText elementTextId="103991">
                    <text>WVNV"

MW

:_’.m‘.’r,7‘,’:vrrﬁ‘rw‘t

«Lag-pom.«w.~W~wmm3v~vuuraw~m~zmmrmamw r

-

,nn .-vw§trx'-HEWFm¥1-MV1PM
‘

4' mi.- n

«~m

4...

av

May

”—7.7,

~v

m

.. m.

sw—‘ﬁ-nr' ~..

xnrvv‘».

—1-.-1-

um- ....,

w—m—

x

~

,

,

"x:

v'

v

.,

—--.

-..

23, 1977

JaneOtto Ottosson, M.D.
Sahlgrenska Sjukhuset
Goteborg, Sweden

,3
‘Fﬁ‘ﬂ‘

.
‘.-&gt;~

_,.

‘yu'l'an-

w.

-.-w

.JKT-r-wamwnm-s

Dear Jan Otto,
have an opportunity to
him
and
meet your son
on June 4. We will have
to care for
him
someone looking for
at Kennedy after his arrival. If
they do not meet, ask him to call my home - 516 466 sunnthe charge will be 10 cents and someone will answer and give
My

him

girls are pleased to

instructions.

r‘
&lt;--

&gt;1;

amuwwrmwmaw

w"

itt

of the APA has completed its work and
recommendations
has written a series of
regarding the use of ECT.
The recommendations will be supported by extensive documentation.
Some of the reports are completed and some are still in progress;
as a group, I believe they will be quite useful as both a reference
source and as a guide to further research.
The Task Force

.

Suva-“73:1:

m":

I read the program description for the World
it is very good. I am indeed sorry to miss

Congress and think

n:

still

The NIMH committee has dawdled and

at this

moment

is

indecisive as to whether it should devote the session to
the facts of ECt or to spend much time on the ethical and political
issues. Since the latter were the basis for my disagreement with
the committee, I do not feel so bad in having left them.
work has been extensive in reviewing the EST
process for the Task Force and for some other reviews: I now
have a cost/benefit analysis statement; a review of the myths of
EST; specific surveys of the use in schizophrenia and in mania;
a small study of the use in the Metropolitan New York area (which
I am sending to Gianomo today); and another theoretic essay. I think
I am now ready to get back to some clinical research.

regards.

My

own

We

look forward to greeting Hans in

New

York.

My

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

best

m

.— ..—

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-.

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,

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�</text>
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                    <text>-.
”n.5,

"mtw—WWWWW'HV“;W

May

Richard Shader,

23, 1977

M.D.

132 Homer Street
Newton Center, Massachusetts

02159

Dear Dick,

I have been using the sedation threshold as a diagnostic
1955, and have not had any complications associated with
this procedure. Recently, I have re—instituted a study program for
another assessment of this test, using the RDC as diagnostic

test since

criteria; in the belief that much of the difficulty with the original
test data was inherent in the lability of diagnosis, and not in the
specificity of the test. To do the present study, my associates

Drs. Martin Heymand Had Timothy Ts'o have prepared and filed a
protocol which has been approved by the appropriate review committees
of the VA Hospital, Northport, and the Long Island Research Institute.
In both protocols, permission has been given to carry out tests in
patients prior to definitive treatment with drugs or EST, and to
repeat the test periodically during the treatment course to assess
the changes in the test with cahnged behavior. Dosages of amobarbital
up to 1.0 gram are given at the rate of 0.5 mg/kg/HO seconds following
the descriptions of Shagass, up to nystagmus, slurred speech and
defined EEG cahnges (higher voltage 20-25 Hz spindling).
In filing for these studies we referred to the extensive
data reported by Shagass (for reference see my summary in Katz, Cole
and Barton: The Role of’Msthodblogy in Classification in Psychiatry
and Psychopathology, PHS publication 1584, 1968; to the volume by
Gordon ClaridgezPersonality and Arousal, Oxford and London, Pergamon
Press, 1967, 274 pp.; and the reports by Mario Perez-Reyes in
Williams, Katz and Shield: Recent Adbanaes in the Psychobiology of
the Depressive Illnesses, DHEW publication 70-9053, 1972. It was
our impression that these reports supported our estimates regarding
the safety of the procedure.

I trust these date are helpful.

Good luck

in your studies.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>,Mwywvw.

v.-&lt;wiw

v

May

Giacomo

d'Elia,

23, 1977

M.D.

Sahlgrenska sjukhuset
Goteborg, Sweden
Dear Giacomo,

to the question of the frequency of BCT
in the
is difficult to answer. We have no central reporting
registry and studies seem to be done on an ad hoc basis. The
best study is that of George Grosser which appeared in the
U. S.

The answer

Massachusetts Journal of Mental Health, 5:12~25, 1975. In that
he surveyed the changes in treatment in 1973-197“. I believe he
is doing anohher survey and you may wish to write to him: Dr.
George H. Grosser, Massachusetts Dept. of Mental Health, 190
Portland Street, Boston, Massachusetts 0211u.

recently completed a survey of the use of
in metropolitan New York and I enclose a copy of that report
We

ECT

have

for your interest.

other source would be the report of the
survey undertaken by the APA Task Force on Convulsive Therapy. The
survey was just completed a few weeks ago and the report is not yet
written. It should be available when you come to the U.S. You may
wish to write to Dr. Fred Frankel, Chairman, APA Task Force, 1700
Eighteenth Street, N.W., Washington, 9.C. 20009 to ask for an
The only

official

copy.

I trust these ideas are helpful. I understand that you
to the NIMH conference this fall, and I look forward to
seeing you at that time. Has there been any progress in your stuﬂy
of the effects of ACTH u—lo on the memory deficits in ECT ?

will

come

My

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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                    <text>_t5§r_

May

23, 1977

Alick Blithorn, M.D.
Royal Free Hospital
London, England
Dear Alick,

Irwin.

he

He

left;

Thank you

enjoyed his

for taking such care of

visits in

what more can I ask ?

my

associate, Peter

England and returned somewhat wiser than

I would be pleased to have you visit us here. I am
not in a position to set up a meeting, since these are ordinarily done
by the training staff. However, as soon as you know your schedule, I
would be pleased to recommend your invitation to them. As soon as
you have an appropriate time schedule, please let me know.

testing program
For many years I dedicated
the energies of the laboratory to program development and only recently
have I dedicated the work to the application of these methors, as they
are, to hlinical problems. I have an automatic negative reaction to any
suggestions that the present methods be changed, knowing that once I
travel down the technical road again, I will be lost for a number of
years, and faced with expenditures far beyong my capacity to bear. Say
Your

suggestion that

we

is interesting, but probably unfeasible.

automate our

reaction, but that is the present state. Most of my efforts
to applying the quantitative EEG methods to drug assay,
are
pharmacodynamic assessments, and clinical studies.
a phobic
it isdedicated

My

best regards.

I look forward to your

visit,

and

will

do what I can.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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"w. Wlww'—Wuu

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.

~

May

mum.- ..

-

“mm

v

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.

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”Wrmuw“-

17, 1976

William T. McKinney, M.D.
University of Wisconsin Medical School
Madison, Wisconsin
Dear Dr. McKinney,

I am pleased to write this
behalf of Oliver Nikolovski, H.D.

letter of

recommendation on

I have known him since 1967 (or 1968) when he joined my
staff at the New York Medical College as a staff research
psychiatrist. He was assigned to the out-patient department where
he has served since. He participated in a-aunboI-of clinical studies,
particularly evaluations of new psychoactive substances in the
treatment of the mentally ill. His work has ail-yr been exemplary) 44
e is a methodical, reliable, and careful worker. He is liked by
his patients and ie-ebte-to create a cheerful atmosphere with

his co-workers.

I relinquished the role as chief of the clinic, he
remained as therapist, and from time to time, participated in ”‘27‘~“§
Jay experimental studies. He has always been willing to assist in
studies and my co-workers have called upon him after I left the
College in 1972.
analmﬂWhe

-

has been unhappy at the College since
has not
he§2::;;ra
received the professional advancement that he
I would
recommend him for any clinical position similar to those which he
has held, and believe him qualified in clinical psychopharmaeoloé;¢?7?‘é‘ﬁ
and psychopathology. Unfortunately, I have not had the opportuni
to assess his teaching
as these are under the supervision of
others at the College,
“1&amp;5WWW/I.)
He

,//”

I trust these remarks are helpful.

.w'l/W

jﬂsdhobﬂg ,u,9'

3

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

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                    <text>-n

hw-

..,..

a."

I v

v'Ir.r.'

he...”

ww-uw-v-uwuwv—w—v-N"

' "' ""

“ '

‘

"'

‘

‘

June 2, 1976

Merrill

T. Eaton, M.D.
Nebraska Psychiatric Institute
The University of Nebraska Medical Center
602 South 155th St.
Omaha, Nebraska 68106
Dear Dr. Eaton.

I am pleased to write this letter or recommendation on
behalf of Oliver Hikolovski, M.D.
I have

known him since 1967 (or 1968) when he
Joined my
York Medical College as a staff research
psychiatrist.
He was assigned to the
outopatient
department
where
he
has
served since.
He participated in clinical

staff at the

New

studies, particularly evaluations of new
psychoactive substances in the treatment
of the
work has been exemplary, as he is a methodical, mentally ill. His
and careful
worker. He is liked by his patients and creates reliable,
a
cheerful
atmosphere
with his ecoworkers.

I relinquished the role as chief of the clinic, he
therapist, and from time to time, participated in ongoing
experimental studies. He has always been willing to assist in studies
and my censorhers have called upon him after I left the College in 1972.
He has been unhappy at the College
since he has not received
fthe professionaly advancement that
he wished. I would recommend him
egfor.any clinical position similar to those vhich he has held, and believe
him qualified in clinical psychiatry and
Unfortunately,
.I have not had the opportunity to assess psychopathology.
his teaching ability as these
are under the supervision'of
-

p

When

remained as a

others at the College, such as Benjamin

Badock, M.D. and Alfred Freedman. M.D.

I trust these remarks are helpful.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.vw-"a‘v

1w:

(pp

_

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                    <text>June 2, 1976
James F. Buses, M.D.

Department of Psychiatry and
The

Human

Behavior

University of Mississippi Medical Center

2500 North

State Street

Jackson, Miss.

39216

Dear Dr. Buses,

I am pleased to write this letter of recommendation on
behalf of Oliver Nikolcvshi, M.D.
I have

staff at the

New

He was assigned
He participated

known him since 1967 (or 1968) when he Joined my
York medical College as a staff research psychiatrist.

to the out—patient department-where he has served since.
in clinical studies, particularly evaluations of new

psychhactive substances in thettreatment of the mentally ill. His work
is‘a methodical, reliable, and careful worker.
He is liked by his patients and crestte a cheerful atmosphere with
his

has been exemplary, as he
co~vorkers.

I relinquished the role as chilf of the clinic, he
realised as a therapist. and from time to time, participated in ongoing
experimental studies. He has always been willing to assist in studies
'and my co~vorkers have called upon him after I left the College in 1972.
When

has been unhappy at the College since he has not received
advancement that he wished. I would recommend him
[or any clinical position similar to those which he has held, and
believe him qualified in clinical psychiatry and psychopathology.
Unfbrtunately, I have not had the opportunity to assess his teaching
ability as this is under the supervision of others at the College,
such as Benjamin Sadock, M.D. and Alfred Freedman, M.D.
He

the professional

I trust these remarks are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>V

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.V

V»: «v

‘vmvz'vwwr r-»—~qn..-z.u- u wwvrr—cwnxw

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June H, 1976
Magda Campbell, M.D.

Department of Psychiatry
York Universiyy College of Medicine

New

550

New

First Avenue
York City 10016

Dear Magda,
Thank you very much for the prompy and helpful response
question regarding EST in children. I have also received
the latest survey by Laurette Bender which will be presented
to the Society of Biological Psychiatry it seems-— it is a
good review covering the most extensive experience in psychiatry
since it spans treatments to 1938.

to

my

In reviewing these data, I find myself in a dilemma.

.

«may

..
2'
.,
a
‘m

.

be done ?NThe APA Task Force on Convulsive THerapy will be faced with
a special problem in assessing these data.

n'”W-M.—y.,ur

in the

we can refer the issue to the appropriate group
of pediatric psychiatrists for their assessment.

Perhaps

APA

n.»....r,..—~,.—,,...

Again,

my

thanks for your assistance; and

my

regards.

"zv‘l—vv

Sincerely yours,
Wv,y-VYW"W“‘

Ia-‘u

axrzE-m-LY'

wwaszw

nan-v

n
w."

It

is clear that the data are mostly uncontrolled, and the evaluations
are principally global. No studies have made the detailed assessments
of neurological deficits or psychological changes follwoing EST
in children. Yet, as the Massachusetts survey in 1973 showed, EST
is given to children, usually over extended periods. What is to

Fink, M.D.
Professor of PSychiatry
Max

.

v

,

.,,

.

Apr,-

.

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                    <text>"'W—"“ V"

13',

"

‘

'“

'

" '—

"u

-

'v-

,

x

--:-:n.v;-.r——~m;.sw

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June U, 1976

rs
~4-

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mw—r-v

jwu

Laurette Bender,
M23

M.D.

Ben Oaks Drive West

Severna Park, Maryland 2llM6

u
.

‘1r-Zt‘mur

Dear Dr. Bender,
Thank you very much

.v—q

~n-m-w-y.

~wvmﬂ'mww‘1'm-

recent report,"Childhood

for the opportunity to read your

and Adolescent Remissions in Adult

Adjustment in Shock Treated Schizophrenic Patients". It is
clear from this survey that the administration of either metrazole

or electrical seizure therapy did little harm to the subjects, and
perhaps assisted the short term adjustment.

Excepting your studies, we have been unable to find
other adequate examples of treatment in children; yet, the
practice seems widespread, as was demonstrated in the Massachusetts
review of EST in that state in 1973. What is to be done 7 Should
additional studies, of the effect of EST in childhood schizophrenia,
be encouraged ? Should the studies be comparisons with drug therapy
alone, or should there be drug and other therapies as comparison groups

many

a

I fear that the APA Task Force will have a knotty problem
in attempting to place EST in childhood schizophrenia in proper
perspective. On behalf of the Task Force, I thank you for the
chance to read your reports. I trust I may share the draft sent
me with the others on the project.

P.

mm

'wv-Wmm

My

best regards.
Sincerely yours,

unsung-weep

.u-Aww—v-

«wr-

W"'l&lt;:m‘&lt;a"'—wiwr

Fwnnm‘v'

A,

Fink, M.D.
Professor of Psychiatry
Max

?

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                    <text>June 9. 1976

Juliq‘v¢:;dlewicx,

M‘D.

Institut De Psychiatric

Hopitul Uhiversitaira Brugmann
h, Place Van~Gohuchten
Bruxelles 1020 (Belgium)
Dear

of

Juliell
Enclosed,

after

much

delay, is our draft reyort, "Effects

EEG and Memory Function in
0 (Org OIuGS) on Quantitative
Normal
e Vblunteers" fur Inna consideration for publication in
Heurozgxchobiologz. ‘I ragrot the dnlaya, but as yuu V111 see, the
analynes have-been most difficult and interesting.
ACTH

You should also-receive parallel reports from Dr. Rhea
Dornbush and Dr. Judith Rapaport. Both have studied ACTHh-lo and
have acmething to any at this time.
My

regards.

—

I
‘-.-v

Sincerely yours,

gigmrvc'rx

'\.‘.

Fink. M.D.
Professor of Psychiatyr

Max

upma~ﬂwwswrwug

50—th

'w-

3'.

‘mygq‘ﬁgpﬂﬂw

w:

gig—m;

{—55—

.41“

we

cc:

W.

Bannita,

M.D.

�</text>
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                    <text>m17'r

«.vwwgm-m

.v.

1......” 73--..

.

..

,w

”m mm

aﬂv

...,,—_.

&lt;.Wuw-'Ax-».-.v

r: '.v.~4www.m‘--“nmV14:"-9:'—-;=

(Irrhnr'a‘nii' n’u'yv.»

..

-r\ .~....-w

ma

w...

Tu'u'”

.1“. .

qm—

A“

,

a... “wen—um .411..."

.-

..

June 15, 1976

Judith Rapaport, M.D.
Department of Pediatrics

Georgetown University Hospital

Washington, D.C. 20007
Dear Judy,

have read your report with interest, and some
on to
sorrow that the results were not more positive. I have sent
We
should
hear from
Dr. Menditwicz and the Journal Neuropsychobiology.
him shortly.

I

it

‘

Henk will be coming to see you Thursday. Please excuse
I hope that I
as I shall be busy with my daughter's graduation.
'
will be able to cash in a rain—check shortly.
me

v

I'mwr.

My

regards.

W‘s-W1

rr

-mz-..-v-v—-

Sincerely yours,

'0.‘l:-'rmm

,1”

AV

«um-M.

.
«wry

t‘riﬁ'ﬂ’nwm“

ku—ry-

run.“

.

wwa.m~,-uwwuu.;-

ww-wmux-wo

.mm’n'rrt

131.27?

my:

an:

Professor of Psychiatry

�</text>
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                    <text>gamma.

.

K‘w- ,,

a... 'o‘xw'.
»

Vﬂ'ﬁ-WW'M
~-.-.~lc‘vn-m‘mnwrm“'-vrw-'Q‘éem‘vﬁmvvew“m

.n«.,.,m,~.—v—w-n_~

V

,

vain“.

may...

.,.,...i

,V“

:.

Julien Mendiewicz, M.D.
Institut De Psychiatric
Hopital Universitaire Brugmenn

up—m m7.y,.......,.,....,.,..r..‘.0-

“mg. .,

,

Viv-wr'm'rlcaﬁ—

wry--5. ”yew.

-Myy..y.v.-73“, 1-»,

June 15, 1976

h, Place Van Gehuchten
Bruxelles 1020, Belgium

Dear

Julien,
is a draft report,

5-10 (Org 01-63):
Cognitive and Behavioral Effects in Hyperactive, Learning Disabled
Children", submitted by Dr. Judith Rapaport for your consideration
for publication in Neuropsychobiology. This report complements the
study submitted last week from my laboratory on the effects of this
compound in normal male volunteers.
Enclosed

"ACTH

Dr. Rapaport has used the same materials and has
worked from the same hypotheses that we did. As I indicated in my
letter, I hepe that you may be able to condider these reports together.
My

regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

,

e ..

..,

w...“

,.

_..,.~..

7.7—

.

V

.

.

..

,.

�</text>
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                    <text>rv"n'rrmw—uv&lt;

..—

—.v—w‘;w&gt;-&lt;

.m‘w‘w «tm'wb-

1

,

M

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Harm.

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w"

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- mm...“:r»—q——-"/~-m~vv—\T~~wv|Wuwm'w- r»,

.-

.....__ 71-12

June 30, 1976
Dear Don,
We

have done one pharmacodynamic study of bromazepam. The

report is enclosed.

these data, bromazepam is hardly distinguishable from
to the amount found in the blood when the EEG effects
are the same as those of diazepam, i.e., we thought bromazepam a more
active agent in the brain (high EEG levels) with lower bbood levels.
Schwartz and Conney of Hoffmann—La Roche suggested that the sensitivity
of the methods was such that there may be an error in the bromazepam
blood levels, and that this finding was possibly an artefact.
From

diazepam except as

The manufacturer is Hoffmann—La Roche;
Bookman (212 695 1400, x3772).

Dr.

Philip

any

clinical experience with the

the contact is

I cannot answer the clinical question as

My

compound.

regards.
Sincerely yours,
Max

Fink,

M.D.

we

have not had

(“Wm-w.

4

‘»

puwwmm—

�</text>
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                    <text>.
.

..

A.

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Jane 30, 1976
Raoul Desjardins, M.D.

RD

Associates

Mendham, New

.

.

.

Jersey

Dear Raoul,

..,

7.3.7.

”w

.L

.vv,

w

up...

Thank you for recommending Dr. Young-ll R0. At the
present time, I have no opening for a psychiatrist and I regret it,
since his credentials are impressive. I shall keep the record at

hand, should the

situation change.

e...

._—Vwm‘".l,.ﬂ.wwm—,.va

Dr. Feet of Organon is en route to the CINP in Quebec
and I have arranged fun him to visit my laboratory and Mercy
Hospital on Friday.
Your comment about Neil Burch is interesting. If he
undertakes a clinical evaluation study, I believe it will be his

first as he has always found such projects uninteresting. He does
have a long record of interest in EEG quantification (it was
from him that I obtained my first period analysis program in 1963)
but his principal interest has been in the electronics and engineering
of the problem, not its application. Only lately, in a single syudy
of cocaine, does he seem to assess the relation between EEG and behavior
after psychoactive drugs.

to DH-52u ? I have been asked whether
we have undertaken clinical studies and I answered in the negative.
you tell me that someone was doing clinical studies ?
Whatever happened

celebration.

My

regards,

and best wished

for a

Did

happy 200th birthday

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

WWW-WW?”

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w--:

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�</text>
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                    <text>¢.-—u-.-,—_sau~.

mew—

Vx~"

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ww‘nwnzz‘mnwmrrnz-mmwv.-

_

.

'

_

mm

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July 3, 1976
Dr. Simon Sanchez, M.D.
129 Asharoken Avenue
Northport, N.Y. 11768
Dear Dr. Sanchez,

I have read your letter of June

29 and your C.V.

with

interest. I regret that I cannot personally attest to your ability

as an electroencephalographer, as the recommendation
American BEG Society requires.

to the

I note that you have had experience with Dre. Abrams, Su and
that they should be able to attest to your
abilities, for surely Drs. Abrams and Su, well trained and modest
men that they are, have complied with the requirements of the American
EEG Society at some time in their lengthy training periods.
Rosen. I am confident

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

'n-wwv”.vrmnw—n,

wn—u'lr-m

�</text>
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July 3, 1975
Mrs, Margaret Henry, Secretary
American EEG Society
4137 Erie Street
Willoughby, Ohio #4094
Dear Margaret,

I have been asked by one of the resident trainees at
our University, Dr. Simon Sanchez, to write a letter of recommendation
on his behalf to the Society.
I am embarrassed by the request, as I am unable to attest
to either his training ror his ability in EEG. He did not attend my
seminars, nor has he workéd in my laboratory. He has worked with one
of my students, Dr. Abrams, who has never participated in a well
defined training program in EEG. I do not know the ability of Dr. Su.

that

For

he obtain

My

this reason, I

letters

from

written.to Dr. Sanchez suggesting
his immediate supervisors.
have

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

,

a" _

�</text>
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V. .

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July 12, 1976
Robert S. Wallerstein,

M.D.

University of California, San Francisco
San Francisco, California 9u1u3
Dear Dr.

Ref: Reese T. Jones,

Wallerstein,

It is

with Reese Jones,

M.D.

this evaluation of my association
of
occasion
his consideration for promotion.
the

a pleasure to submit
on

first

met Reese during the early days of research into
reseaarhers had to struggle to get permits to have
marijuana,
and
cannabis
supplies were available only from the illicit markets.
Reese carried out some innovatihe studies and freely shared his findings
and experiences with us at the New York Medical College. Later, as he
developed the long term studies, we were able to share our experiences
in Greece with him, and to learn from his observations regarding
tolerance. Concurrently, his interest in electrophysiology brought us
to some common meetings and I have heard his presentations with interest.

I

when

In these experiences, I have found him to be an earnest,
thorough, and sophisticated worker, and an unbiased observer. On one
occasion, in his presentation to the American Psychopathological Association, I was on the committee that unanimously awarded him our

first

Morton Prince Award

for excellence in presentation.

initial opinions that he was a
work
and
continues to be innovative,
his
bright young researcher,
His
presentations at the recent conference
well controlled, and systematic.
and his discussions were excellent.
done
on chronic cannabis use were well
He

has sustained the

I cannot evaluate his teaching ability directly, as I have
On these occasions, his presentations

only seen him at national meetings.
have been lucid and logical.

It is

a pleasure to recommend him for promotion. Recently,
I submitted his name with my recommendation for his consideration as
a paincipal scientist at the newly formed Long Island Research Institute.

“AP.

-wrr~vrn—»vr

M"

I

trust these

comments

are helpful.
Sincerely yours,

w-nxmyw-muw-nww:

xv-

wwwrv-(wJ—py—

-

Max

Fink,

M.D.

Professor of_Psychiatry

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                    <text>‘11“? 1—«27..:-.~m-w-.-w,-

“a

m. win-w.

'w;

sv‘~x.v:vv‘§12‘-,Wg(Furs x'nm.-..‘_-.'vvﬁﬁ—u-Uvmwwyv-r’utugiv‘wy

m...

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pun

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”N.“

n.

,

mrJr—lvvh‘lw‘dvfwmw‘mw-h

July 13, 1976

w.

merma-n-sm

Julian

Mendlewicz, M.D.
3-1020 Brussels, Belgium
Dear

Julien,

1-.»

It

am.—

v-a'vw-vq-m

v
"Iva-1

("r

m.

7....

v.1...

the meetings as

was nice meeting you
much as I did.

in Quebec. I hope you enjoyed

On my return, I found the letter of acceptance of the
Rapaport paper. I called her, and she has agreed to send you a shorter
title and a corrected, clear version of the tables.

mum.

Fw-wvr-‘ar

up”...

Dr. Dornbush has agreed to send you a

of the effects of

ACTH”010

in elderly subjects.

draft of her report

I have reviewed the manuscript and made a few corrections
which I believe improve the draft. Please substitute this draft for
the one in your hands. This one is marked (VI:7-8—76).
Memory"

title

of
is acceptable; as is the
The

shorter

Thank you
My

" ACTH

list

,

Quantitative

oi'hgy words.

EEG

for your consideration.

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry
Max

and

»

..

.._,7

..

.-

5

WWW”

�</text>
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                    <text>rvvt—U‘m-z-"w~.-; \

wx—y. ,-

ma «may, we uwtv mm: D, ."wvlu , ‘--.4.&lt;w,w.q..-wu«.¢\~. .wo-uapm m.)- Avid-'nxuw.’"—9,. I'w'.‘
-

my V11 ~»y

yum\ 3'”m y—m .w “my“... man a...“"jumpy.
».

nu,-,..w...ry~.u.wm.yv(u~——~—my

mar—“munww

.

.e

(v

y

-,

7:7,.»

,.

September 16, 1976
Mr.

Philip

G.

Sunderland

1908 Sunderland

Washington, D.C.

fiace

20036

Dear Mr. Sunderland,

material that you requested in your letter of September
13, 1976 will require some work-- to summarize the reports and select the
references. We would be glad to undertake such a review at the rate of
$lOO/hour, with an estimate of $0 hours for one that may meet your needs.
I trust that this will be acceptable.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

~~( «rc‘ a.

..

'1'

�</text>
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                    <text>August 2a, 1976

Daniel X. Freedman, M.D.
Chief Editor
Archives of General Psychiatry
Chicago, Illinois
Dear Dan,
On my

return

Re:

M8

##024

from my holidays, I found your

letter of

26 with the critiques of the paper”Effioacy and Shfsty of‘lhduoed
seizures (EST) in Man? I cannot say that I am surprised, for I have
become accustomed to unusually sharp criticism of any report that I
write on EST. But I did find many of the comments useful, and taken in
the spirit of improving the product, I shall try to correct some of

July

the omissions and the errors, as well as add a section of clear critique
of the status of our present knowledge. I do think that the last request
is for an additional paper, but perhaps the addition will not be too

large

WW“?

v

.1.-r.y"-',-¢v

-_—

pwqwm'w

«serum-man“.

-~‘I:

"a,

wuwr‘

“In."-

7.,

and may be

useful.

In your letter you indicate that "I have decided my initial
reaction is off target - I enclose a letter I wrote; I also enclose Noch

Callaway's response." Neither your letter nor Noch's response were in
the package, and if you still think these would be useful in re-writing
this report, I would be grateful to see them. (I received critiques I to V).
I have some specific questions for reviewer # 2 (begins 'I
appreciate the timeliness of this review, esp. . . . '). He argues that
the issue of the comparative efficacy and safety of EST vs. antipsychotic
and antidepressant drugs is not dealt with till at all. I thought that
I have cited the principal articles in this regard; would it be possible
to ask whether there are other citations missing? If the criticism is
that the presentation is poor, then I accept that criticism and will
re-qrite it; but I do believe I have cited the most relevant articles.
I also find his statement 'there are hints of the possibly overly
sanguine clinician—enthusiast in some parts' helpful, and have attempted
to take a more judicious posture.

this

In any case, it will take a few weeks of extra-effort, but
means a delay to get the text back to you-- probably early October.
My

thanks go your

My

regards.

to write such fine critiques.
I

.m

many busy

researchers

Sincerely yours,

r-m—vm-v

’..1w:'

who

Max

Fink,

M.D.

took the

effort

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                    <text>'w-WAa-MW‘WWJ

11".

"'v“"'-‘,‘-:&lt;--r'uwrvr .uwu—quuwwy-owwmmwJ'Unwv

mu

m

7‘" mu,«a. ..

r. rum-n- ..

-

nu.

sup... «my.. a....

Wm.

r:mnur'm-mm‘n.w.&gt;

,.

.._... w. 4--

wwmmwn-m'

WWW“ ’- l...

August 11, 1976
Dr.

J.

Fishman

Montegiore Hospital
Bronx, New York
Dear Dr. Fishman,

I have just read your article in Pharmacology describing
progress with the long acting formulation of naloxone, and I congratulate
you on the progress which you have made. It is heartening to read that
the possibility is ever so much greater that an implant will be
possible for treatment in man. The hopes and vision of the late 1960's
regarding the treatment of opiate dependence wane obscured by the
political events of the period and the drive for methodonization of
the nation.
While I

no longer involved in the testing of narcotic
hear a relationship to the study unit at the
New York Medical College. I am confident that Dr. Richard Resnick and
Dr. Alfred Freedman would both be interested in cooperating in human
trials as soonn as the preparations are tested for toxicity.

antagonists, I

still

Again,

am

my

congratulations.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

v‘w-V‘M‘rl‘w‘rp‘

. Irv.

-

"w'w‘l’

�</text>
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                    <text>4-4 - v-r-.—-

... we»

yrs

~

',w":»“ xv»-

2‘

an" «nary-w

umwﬁﬂmwxmmn:

'
V
av. we-mxn-p.»...

m

,

.

'

_

,,

.

,

.

turr-

mun- we— ,7

,

”new: AM)». wranwm

a“,
a«ww—nvv~;.~~w-W»-wmqgm.

"
'-

-

W'v.ﬁr—"~Vwﬂn‘l&lt;mﬂw“

August 11, 1976

Alfred

New
New

M.

Freedman, M.D.

York Medical College

York City

Dear Al,

I have just read the report by J. Fishman, "Preparation
and Evaluation of a Sustained Naloxone Delivery System in Rats" which
appeared in the journal Pharmacology 13:513~519, 1975. It is excellent
and suggests that a long acting formulation of naloxone is feasible.

I

commend

the

article to

you.

have sold the house in Setauket and returned from a
trip through Great Britain (for a nation with such beautiful
countryside and and exciting heritage, why can they not learn to
cook food tastefully ? ?).
We're busy with college preparations for
the last of my children and anticipate with some optimism the next year
We

long

at

SUNY.

My

regards to Marcia and Irv.
Sincerely yours,
Max

Fink,

M.D.

-,,1-

1w“.—

�</text>
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                    <text>w-m‘w".7"7,.r‘,‘w,,-m‘vw~..m&lt;warn mum

v

.

vv‘V/Wﬁﬂ'

uv-w WV .- n

IXWIruwlnuwm-w-wg

rump-“WM w—u- "tA-Wrmﬁ‘wlﬂuA'mmimw.~-v..n-—u‘..._..,-u

_,,.

.mttmmvwvw .m-wv..-“

August 11, 1976

Paul Blachly,

M.D.

University of Oregon

Portlan,

V

ﬁnnr‘.

,—~;~.~wmwvz

1......

www.—

ear—w

Oregon

Dear Paul,

I want to congratulate you on a fine issue in the latest
I note on my return from my holidays that a number of
readers have taken your advice and written for preprints of my articles.
(Incidentally, the one on cost/benefit was sent to Dan Freedman. He sent
it to 5 editors, and each chewed the report over like it was a
favorite bone-- criticizing the length (too short and too long); critic—
izing the inclusion of schizophrenia (EST is not a treatment, only a
sedative); criticizing the language (too loose, needs tightening); etc.)
(#3) of

GTE.

s
n

arm

——r-ww,vn

vr'wawlr-er'

W

writing with regard to the announcement of a course
I would so like to cooperate and participate but the dates you
suggest are those that conflict with the APA Divisional meetings in
New York where I am scheduled to give a report on EST. If it is still
possible to change the dates, perhaps the next week-end ? Indeed any
week-end thereafter in November will find me in California.
on EST.

I

am

WWW

"Wv

"am-w:

sure you have written to the APA NEWS-sad the announcement to
I believe. I would also send it
Med
Sabshin asking his intervention for its publication in
directly to
the newspaper. Otherwise it will get lost on page 35 or so.
In addition, I

am

Mr. Robinson,

My
erme—rqqu—u

regards and agaén

my

congratulations.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

P.S. This

letter is not for quotation, please.

m- :rwwuv-uw

_,_, ,

�</text>
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                    <text>John

M.

Davis,

SepteMber 2h, 1976

M.D.

’

Illinois State Psychiatric Institute
1601 W. Taylor Street
Chicago, Illiniois 60612
Dear John,

involved in a cost/benefit analysis of EST. The
draft that I submitted to the Archives was returned with many good
suggestions for improvement. Among the comments was a suggestion that
I include a table of the comparison studies of EST and drug therapy,
in a fashion similar to the reviews that you and Jon Cole have in~
cluded in your many evaluation: of drug therapies. In checking
the latest edition of F a K, I find that you and Jon have included
EST in your 'Summary of Controlled Double Blind Evaluations of the
Antidepressant Drugs', vol II, page l9h3.

I

am

if

I could obtain the citations
which you considered acceptable for this revieWb- those reports that
you included in the 7 studies greater than placebo, 1 equal toMy
placebo: h greater than imipramine and 3 equal to imipramine.
own records include many more studies , suggesting that my criteria
of acceptability are less stringent than yours.
for each

It

would be

Is

it
7

column

Many

helpful

possible to indicate
thanks.

which papers were assessed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>rag—ur—

‘m

7-”

‘Ww‘”WW"""".NW1w4-v'7wawair-1

—-v.-vxww:r

J,

mmmv

.._._..

~

VT‘FI'“

wuamv"mm“meW'erw "N-Wﬂmwmﬂmm—mm".wv

--

wwwrurnwvw,

vuw

“a,”

q.._,..”

Septquber 2h. 1976

Julian Hondelewicz, M.D.
Institux do Psychiatric
Hospital Untversitaire Brugmann
h, Place

81020
Dear

Van Gehuohten

Brussells.

Belgium

Julian.

associates have been over our paper on ”EEG and
Tank Performance after ACTH h-lo in Man” with great persistence and
have found some sentences that did not reflect their point of View.
_

My

this draft, an&amp; if the paper
is not yet in gallqy, I.vou1d ask that this copy replace the one that

These corrections-hawe been maﬁa in

you have in your hands. I think
improving the galley.

it

would be

less expensive than

,

I tfust this is in time.
many

thanks.

Sincerely'yours,
Max

Erik,

M.D.

Prorbssor of PSychiutry

5...", ‘ wﬂw.

�</text>
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                    <text>October 7, 1976
Dear Peter and Vi,
The enclosed pictures reminded me of the many pleasant
hours we spent in London. I think that Rachel has captured some of
the enthusiasm of the children, and I hope that the pictures give you

as

much

pleasure as they gave
After

we

of roads, places to

left

me.

London, we were very lucky in our choice
and of course the weather. We

visit, hotels

enjoyed England and Scotland so much that

we cancelled our trip to
additional week in south-west England, travelling
to Tintagel to follow the history of Arthur. While we in the 0.8.
celebrated our 200 years, in our English travels we were brought
face to face with the thousand years of history. It was a good
time for all of us.

Italy

and spent an

tried to get back to work and
visited last week and we discussed
some trials of Intel in psychiatric states. I have broached the
subject to some of my colleagues, and am faced with one of two
reactions-- "Nonsense; it can't work" or " Well, nothing else seems
Since returning, I have

have succeeded only

lately.

Derek

to work well, so why not". From the later respondents I hope to be
able to put together a few studies in hyperkinetic children first; and
bipolar depressives second. Derek seems well and spoke of how he is
enjoying the work. But organization work has some difficulties, which
only became apparent when we had to decide on the actual procedures
to follow. About Gerdaxyl, we could come to no conclusion. I suggested
that clinical trials could be done in this country, but I was sure that
you could do as well in your clinic as anyone I know here.

is quite empty now; all three children are
at college and Martha and I have the evenings to ourselves. Some
of our energy is going into fixing up the house and garden, and we
Our house

away

go out for meals more often than we have for many years; but
most part we seem to be adjusting to the 'empty nest' syndrome.
Of course, the children are coming home for the holidays next month,
so it is not as 'empty' as it may seem.

to
for the

seem

still

Give our regards to the children. I
want to come
visit your clinic. If Derek keeps his promise (and I believe he
will) I should be back in England in late winter or early spring, and
and

should like to drive out to Oxfordshire.
My

very best-- I hope the house
As

is all

ever,

you expected.

�</text>
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                  <elementText elementTextId="103973">
                    <text>October 11. 1976
Docent

H—1021

Peter Hales:

Hungary

Budapest

Dear Dr. Halaaz.

for your 1nqtiry. I regret that I do not
this laboratory at this time, but will keep your
file for reference, should an opening appear.

Thank you

’

have a pos1t1on in

npplication

on

You may wish to write to Dr. Jan Vblawka who is
gF'
3Q the Missouri Institute of
(5hoo Arsenal
~

now

Psychiatry
Street, St. Louis,
H1asonr1 63139) or Dr. M1chael Taylor (Professor and Chairman, Dyyartment
bf Psychiatry, Chicago medical School, VA Hospital,Ch1cago, Illinois),
[’both of whom are Innded for additional positions at this time.

i‘L

j

,

=

Sincerely yours.

,

Fink, 14.1).
Psychiatry
Progessorfof
:7
/” ,_._

Max

l
,

,

‘j’
'

.

1:”

�</text>
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              <elementText elementTextId="61523">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>u
”w"...

Nmrv&lt;m-

—

,

«Ml-.7.

,nt'n'r-n-I'

Wm»...

,

K". e...“mmmm‘n'w“"lvn"‘l’?ﬁ‘.'mm'w

.7

October 18, 1976
Herman van

Praag,

M.D.

Dept. Biological Psychiatry

Psychiatric University Clinic
Groningen, Holland
Dear Herman,

I have received your latest annual report, and I thank
for the opportunity to gain some insight into the new developments
in biological psychiatry. The extent of the program is impressive, and
when I add the time you must spend visiting and lecturing around the
world, it is even more interesting to see the extent of the accomplishyou

ments.

it that

Rumor has
? Can ue

Is that correct

ﬁerusalem in the future
Again,

my

?

you

will

expect the

be or are already in

same

Israel.

enthusiastic programs

thanks for your report, and

my

from

best regards.

Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

.MWW

�</text>
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"Grovvrzwywurrw-“v

“A

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mum

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In}

October 28, 1976

Hrair
New

M.

Babikian,

M.D.

York Medical College

Westchester County Medical Center
Valhalla, Now York 10595
Dear Dr. Babikian,
Thank you for your kind invitation to participate in the
series of lectures on Drug Abuse. I regret that it wéuld be a difficult
responsibility for me to attempt to present the data on drug abuse
at this time. Since leaving the New York Medical College, I have
turned my attention to other interests and I have no personal
acquaintance with the latest developments in narcotic antagonists
or cannabis-- two subjects that were my interest when I was at the

College.

I am confident that Dr. Resnick, who has sustained the program,
will be able to present the latest information on the antagonists.
Should you wish to include a review of cannabis, I suggest you call
on Dr. Rhea Dnrnbush (now at the Reproductive Biology Research Fdn,
#910 Forest Park, St Louis, Mo.) who is editing two volumes on
cannabis summarizing our studies as well as a conference which she
chaired in January. A third candidate would be Dr. Arthur Zaks.
Arthur has developed one of the most active of the methadone treatment
programs in the city. He has continued his research interest in
carrying ourtstudies of levomethadyl in his practice. He can be
reached at Flushing Queens Medical Associates, 136—80 Roosevelt Avenue,
Flushing 11354.

for

I trust these suggestions provide an adequate replacement
in the future, be interested in presenting a
on convulsive therapy, I would be glad to do what I can to

me. Should you,

program

assist.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>vmv,1-r&lt;.«
r.

.,

.

.

,,v._ ..

,. -..

,

,.

'“vr'm. .... 7:“.

-W a:

f‘FV'vﬂYﬂ

"“h‘w‘ll‘l‘.’—u(tﬁ‘ wwwwu-s-;nanuw ..

“w"w’WWWrrwﬂv-awnvwvmwlwx-

'

s-u

NF.

9......“

..,-.

-Ww.mmwm-

..

I-‘-"r'*'&gt;—L‘-:\-'Wr~

A

i

-

mew

October 11, 1976

Morris Lipton, M.D., Ph.D.
University of North Carolina
Chapel Hill, North Carolina
Dear Norrie,

I am working on a project involving dietary factors in
hyperkinesis; In talking to Judith Rapoport, she told me that you had
chaired a committee review of the Feingold and other hyptheses for the

Nutrition Foundation.

we

...

my

a copy

w-n-»L;-.-wvm7.w~mw‘nw,.,

ACNP

?

Is the report published
Thank you

If not, is it possible to obtain

?

for your advice.

Now

that the chores for the

are over, perhaps you can get back to more
My

self satisfying

regards.

W'HV

yaw-aw,

Sincerely yours,

1ym"m.

urn-m

«mummy:

Ww'l

(mum—r

.

v:

immannxrxnwmcvwn

:«r

Wm.

r-

.

‘Nn-nnam"qu-':v'l

.1

,

..

.‘qm‘ar-ww-n

Jaw"

Fink, M.D.
Professor of Psychiatry

Max

work.

�</text>
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54

i

.

m.mar-m

w—ouV-ww-v-w-WVu-v'vw

2~

:v.

~

mmwmwwxmmmwumw"mrwwﬂnmnh

.

,

V.

,— ,

“7

—..

.V, mi N...

I

...

...

,
.

"W.

...

N.

....._,,..~.m.,...,..u...w...,_n...

i
E

-

October 29, 1976
William J. Darby,

M.D.

President, Nutrition Foundation
#89 Fifth Avenue
New York

City

10017

r".

nnwyv-wvrm.-

Dear Dr. Darby,
We

have become

interested in testing

some new compounds

in the alleviation of the syndrome of hyperkinesis in children.
Our interest is in the possibility of blocking a central allergic
response to food additives as allergens. We wrote to Dr. M. Lipton
for some help in the report which he chaired on behalf of the
Foundation.

has referred us to you for a copy of the reports of
the Nutrition Foundation regarding the possible role of dietary
He

factors in hyperkinesis. I would
reports that may be available.
Many

be

grateful for copies of

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor-of Psychiatry

any

recent

,

,,

,

�</text>
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7m.

,7
v

x
.

.z-mwmnm

m

November 5, 1976

Daniel X. Freedman, M.D.
Chief Editor
Archives General Psychiatry
950

East

Chicago,

59

Street

Illinois

60637

Re: Ms.

#QORM

(Revised)

Dear Dan,

Enclosed are two draft copies of the revised version of
"Efficacy and Safety of Induced Seizures (EST) in Man". The draft
reflects an extensive revision and my attempt to answer the inquiries
and suggestions of the reviewers of the

earlier draft.

I trust this approach is useful to the profession.
My

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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November

William Zung,

.—

.

2a, 1976

M.D.

Duke University Medical Center
Durham, North Carolina

Dear

Bill,
programs is quite extensive, being the
13
than
more
years effort. It is not possible to duplicate
and the documentation without an extensive effort which
Our

product of
the

files

library of

justified by your letter.
If there is a specific problem or program which may be of
know what the question is and the capacity of your
me
help, let
machine, its configuration and characteristics, I will be glad to
send you what is needed.if we have it.
does not seem

Good

luck.
Sincerely yours,
Fink, H.D.
Professor of PSychiatry

Max

&lt;;‘:"r —r\.‘v

r.-w»~‘~»..~-—-~—

-

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w

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1‘

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7.

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November 25, 1976

Dr. David Avery, M.D.
VAH—

Palo Alto

California

94305

Dear Dr. Avery,
Than you for sending me the preprint of your report,
"Electroshock: A Lifesaving Treatment Shrouded in Myth". It is
well written, and makes good points in the issues that have
confused the public. I am not sanguine that Psychology Today will
publish it, but perhaps their editors are less biased than I

think.

I am impressed by the figures that are included. I
presume these come from the manuscript on the efficacy of ECT and
antidepressants. The figures should have the actual articles cited
from which the data are derived. If these are not from that article,
rather than
then they should be prepared for the psychiatric press
‘
the public press.

I could not find citation 36: it seems to be in error.
of the others are incomplete, but completeness is not necessary
for the lay journal.

Some

Let me also congratulate you on the fine review that
has recently appeared in the Archives. The analysis of deaths with

EST and antidepressants
of my reports in press.

is

most

useful

and

is already cited in

two

I do hope that you will continue yuur interest in EST. The
Task Force on Convulsive Therapy has been reviewing the evidence for
safety and efficacy of EST, and we have found a number of problems for
which the evidence is lacking. It would be good to have another unit
carrying out the kind of careful studies of EST suggested by these
reports. If you come East on a visit, come and visit us at Stony Brook.
We are developing a study team for EST research and we would enjoy
APA

meeting you.

My

your other

please send

thanks for the opportunity to read the report and for
efforts. When the antidepressant review is available,

good
me

a copy.

My

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

Xt

School of Medicine

W

[DcpnrnncntofPsychhuryznuiBchuvknulScmncc
PSYChOPhilrnmaﬂogﬁ’

[laboratory

-

EEG

‘

1

Re:

To Whom

It

May

Stony Brook, N. Y. I794
Phonc:5]6444—2447

John Kramer, M.D.

Associate Professor
University of California - Irvine

Concern:

I have known Dr. John Kramer for many years—~as a friend,
student, co—worker, fellow scientist and fellow teacher. From 1958
to 1962, he was a member of my staff in the Department of Experimental
Psychiatry at Hillside Hospital. When I moved to St. Louis, I invited him to join me and was keenly disappointed that he decided to
move to the Far West.
Since then, I have followed his career as
administrator
in SAODAP, and most recently, at his
as
researcher,
week
I
a
spent
as
invitation,
visiting teacher at Irvine.

teacher.

John

He

is

a dedicated,

resourceful, serious researcher

and

has approached the problems of drug dependence from the

innovative point of view of social history.

His writings on the

roots

of our present dilemma in opiate and cocaine use are outstanding. He
has carefully distilled centuries of history and has written excellent
reports on heroin use and treatment which are important to the present
dialogues gh.heroin maintenance.
In his experimental work, his studies on antidepressants
remain as important contributions to a rapidly developing field.
In his teaching sgssions, I have found him to be liked by the

students, responsive,

courages discussion.

I have

no

and through.
A

hesitation in

He

presents ideas fairly,

recommending

Fink, M.D.
Professor of Psychiatry

Mszg

en—

John Kramer for promotion.

Sincerely yours,
Max

and

�</text>
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                    <text>STATE UNIVERSITY

or

N‘r’iW

Health Sciences Center

YORK AT
-

srorw

BROOK

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phone: 516444-2447

December 2, 1976

Samuel B. Guze, M.D.
Spencer T. Olin Professor and

of the Department of Psychiatry
Barnes and Renard Hospitals
Washington University
School of Medicine
Head

h9h0 Audubon Avenue

St. Louis, Missouri 63110
Dear Sam:

Enclosed are some reprints you requested. The thesis
and behavior has been tested best with antipsychotic
of
drugs. It is Still an idea with thymoleptics. The best
report is the diethazine study (1958). The clearest pre—
EEG

diction of antidepressant activity is cyclazoeine
and recently, the studies of mianserin by Itil.
My

(1969)

regards.
Sincerely yours,
Max

MF:fg

encls.

Fink,

M.D.

�</text>
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                    <text>W
X:

STATE UNIVERSITY OF NEW YORKVAT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

-—

‘

EEG

Laboratory

Stony Brook, N. Y. 11794
Phone: 516-444-2447

'
.

December 2, 1976‘

Jon F. Heiser, M.D.
Asst. Adjunct Professor and
Asst. Chief, Adult Inpatient
University of California

&amp;

Emergency

Psychiatric Service

Medical Center
101 City Drive South
Orange, California 92668
Dear Jon:

While I am sanguine about my ability to identify projects
and issues which are currently of national significance, I am sorry if I

suggested that I could predict the behavior of national funding committees.

Such committees are now made up of representatives of the laity and
minority groups and no longer need be the best in our society, nor the
most rational. Hence, my hesitation in even suggesting that I (or any—
one) could predict their behavior, which often is formed by such issues
as geography, color, "old—boy syndrome", etc.

If you ask whether there are target issues of high
which should be fundable, try the following.
1)

patient to

How

can one

(a)
(b)
(c )

predict the responsive

priority

from non—responsive

antidepressants

lithium
EST

(How

to predict the end point of

EST)

to drug therapy? To
treated differently than men by psychiatrists? Are the distinctions justified by biology? If yes, by what biological differences?
EST?

Are women

2)

Do women

3)

What
What

respond differently than

is the efficacy

men

and safety of

MAOI?

In what conditions

is their relative merit against other treatments?
are these useful?
there any truth in the legendary statements of toxicity of MAOI?
.

(5

Is

any clues to a genotypic diagnosis (clafhfication)
system? For example, under what conditions does the sedative'threshold pre0
dict course and therapeutic result?
h)

Are

there

�Dr. Jon F. Heiser

December 2, 1976

Page 2

critical, general issues that could sustain
without
project
getting involved with technical issues of
chemistry or electrophysiology.

a research

These are some

'

Good

luck.
~Sincerely yours,‘

Max

MF:fg

Fink,

M.D.

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

—-

EEG

Laboratory

Stony Brook, N. Y. 11794
Phone: 516-444-2447

_

December 22, 1976

Ms. Marion M.

Brault, Staff Assistant

Cooperative Studies Program
Veterans Administration
Department of Medicine and Surgery
Washington, D. C. 20h20
Ref:

lSl—I

Dear Ms.

Brault:

I plan to attend the Veterans Administration
7 and enclose a copy of my
abstracted C.V. I look forward to reading the material
submitted by Dr.Karacen.

meeting of February

Sinc rely yours,

Fink, M.D.
Professor of Psychiatry

Max

Mszg

encls.

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center
I948

School of Medicine

Department of Psychiatry and Behavioral Science

'

Psychopharmacology
Iaatxaratory

-

—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

,

December 23, 1976

Dorothy Dobbs, M.D.
Abbott Laboratories
Abbott Park
North Chicago, Illinois

6006M

Dear Dottie:

In checking

my

files I

protocol, dated October 12,

found the enclosed draft
1973 for an EEG assay of

SP—l (A—hOlTh) and some notes regarding conversations
with Drs. George O'Brien and B. D. Holland. The file
contains summaries of two studies by A. S. Keats.

best as I recall, we negotiated an agreement,
supplies, when I received a call
terminating the discussions.
As

and were awaiting

for

It

was good

to talk to you again.

a healthy and happy 1977.

My

best wishes

Sincerely,

M

Fink, M.D.
Professor of Psychiatry

Max

MF:fg

encls.

�</text>
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                    <text>STATE UNIVERSITY

05 NEW YORK AT

Health Sciences Center

-

srom

BROOK

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

-—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

,

Laboratory

'

_

,

December 23, 1976

Keith F. Killam, _Ph.D.
Department of Pharmacology
School of Medicine
University of CalifOrnia - Davis
Davis, California 95616

Dear Keith:

Mindful of your comments at the ACNP meeting
in New Orleans, I am writing to ask for a list of citations
(and copies of the reprints if available) describing your
studies of psychoactive drug effects in simians.
The meeting was a good one, and you

are to be con-

gratulated in successfully weathering the stormy
an

officer of
My

ACNP.

voyage as

thanks and best.wishes for a healthy 1977.

Sincerely,

M

MF:fg

Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

is

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

/

W

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

Dec ember

23, 1976

Mr. Don Cheetham

Smith, Kline and French Laboratories
1500 Spring Garden Street
Philadelphia, Pa. 19101

‘

Dear Don:
At the ACNP meetings, I shared a problem with
John Buckley and he referred-me to you. I am establishing
a clinical psychopharmacology research unit at the VAH -

Northport. Before giving our patients

new,

active

com-

pounds we wish to have them drug free for one to four
weeks, and can only do so if we give them a medication,
albeit inactive. Can you supply us with 1000 each of
50 mg and 100 mg PLACEBO — Thorazine?’
Thorazine remains the most frequently used antipsychotic and we

transfer patients to placebo with minitheir part, or that of the nurses.
have two studies approved, which will begin

should be able to

mal anxiety on
We

in January: clozapine in tardive dyskinesia; and a phase-I
evaluation of a new psychoactive drug, GC—h6.
,

-

let

If there is

me know.
My

a charge for such supplies, please

best regards.

Mszg
cc: John Buckley

-,

Sincerely,
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

——

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

December 23, 1976

Stanley van den Noort,

M. D.

Dean

California College of Medicine
University of California Irvine
Irvine, California 92717
—

Dear Dr. van den Noort:

I am pleased to submit this reference on behalf
of Dr. Jon Heiser. I have known of his research interests
from his publications, and came to know him much better
during my recent stay at Irvine as a member of the visiting
faculty.

In his writings and our discussions, he has im—
pressed me as innovative, logical, and careful. His studies
of physostigmine and propranolol are significant additions
to medical therapy. These developments were based on care—

ful clinical observations, logical inference,

and extensive

pharmacologic knowledge. In his discussions of his present

interests in computer diagnosis and information processing
for psychiatry, he shows an active interest in an important

and developing research problem.

'

is a reserved,.pleasant, and responsible person,
interested and enthusiastic participant in my

He

who was an

seminars.

I

am

pleased to

recommend him;

to consider
if
ber of this University faculty.
even more pleased

he were

a

although I would be

position as a

his.

mem—

Sincerely,

Mszg

Fink, M.D.
Professor of Psychiatry

Max

,

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a»,

y...m‘

r...

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www.cqymI-nvum

gamma... Igmw'mm.wwnw_nutm'm-&lt;~

”mm

wan—,— r.n-v-n——..v._.—.ww_r.—.—,_

saw-cm

.vw—er—"V

.

December 27, 1976

Robert Wallerstein, M.D.
Chairman, Department of Psychiatry
Langley Porter Neuropsychiatric Institute
u01 Parnassus Avenue
San

Francisco, California 9u1u3

Dear Bob,
mm pleased to submit this letter of reference on
Dr. Lorrin Koran whom I have known since the summer of
1972 when he joined the faculty of Stony Brook. During these
four and a half years, I have known him as a fellow teacher,
committee member, and co-worker on a number of proéects.

behalf of

I

For the past two years, I have urged Larry to undertake

research studies in

my Diviiion. His decision to return to
California is a keen disappointment to me, for I have found him
to be one of the brightest and thoughtful young men in the

some

Department.

He is a fine teacher. He accepted responsibility to
the
develop
Psychobiology systemsteaching program. He prganized
the staff well, and attended all the sessions during the first
year. The students were treated to a mentor-student relationship
that is rarely seen, and the students were keenly responsive
to his interest. The same can be said for the daculty-- I do
not think that I have been called upon to work as hard, nor to
satisfy as high standards, as in participating in this course.
During the past year, he repeated the effort, and his leaving the
Department will leave a void that will be difficult to fill.
He

is

He

is personable, reliable,

an innovative thinker. He has developed some
ideas
as to the biochemical basis of schizophrenia-—
interesting
ideas that are quite consonant with the type of work that is
ongoing at the Institute.

faculty, staff,

highly.

and

and well liked by the
miss
I
him, and commend
will
students.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

him

“mm—"v...“

nwm- .. w “was“ m
7

- nwm-w—wm

�</text>
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                    <text>r...

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December 29, 1976

Ing.

M.

Matejcek

Sandoz Ltd.
#002 Basel, Switzerland
»

Dear Matejcek,

I was pleased to receive the enclosed inquiry and as
I answered the many questions, I became more enthusiastic; hence
this letter. Many years ago, in 1968 and again in 1969, I organized
meetings in my laboratory in New York. I remember a session at
which Creuzfeldt came and argued very logically for more basic
studies. At the time, I ignored his comments, but lately that
need had become all the more apparent.
I know that some workers are occupied with the technical
issues of electrodes, EEG reduction methods, etc. But these issues
have been solved, to some extent, and what seems to be needed, are
studies relating the EEG changes to behavior. The diagnostic use
of EEG profiles to define new drugs has been successful; some
applications to pharmacodynamics have been interesting; but we
lack the understanding of the significance of fast waves for
behavior for example. Past waves increase after barbiturates
(sedatives) and thymoleptics. Are the chemical changes in the
brain the same or do these same rhythms reflect different chemistries?
Or, as is also likely, we have not yet resolved the differences
in the fast waves after barbiturates and thymoleptics ? Further,
of what predictive value for neurohumors are the EEG changes.
We know that anticholinergic drugs elicit the same BEG effects
as the thymoleptics. Does that mean that thymoleptics act via
a reduction of acetylcholine in the brain ? And so on.
have struggled for years to have pharmaco—BEG recognized
At the ACNP, for example, each of the early years
was marked by an BEG symposium, but these became redundant and
the memebers disinterested when we failed to show the scientific merit
of the work. At times, the data has been presented at psychiatric
and at BEG meetings, but these disciplines are interested mainly
in the practical uses, and ever since psychiatrists decided to ignore
the sedation threshold work of Shagass, Goldman and
they have
We

at major meetings.

Itil,

.

-..

v.

_ yum-“1......—pg,» .-

�..........December 29,

Mr. Maeejcik

1976

..... ......

page

2

ignored the new developments in EEG and drugs. I think that
meetings should be held independent of the main societies, and
related th them mainly for the convenience of timing and the
reduction in expense. Surely, meetings should be organized
alternately in the U.S. and Europe, perhaps in Asia when the
opportunity presents. If a meeting can be held in a working
laboratory, then it should be held there-- giving the participants
a chance to see the facilities and ask questions regarding tech—

nical issues.

Society should be organized formally, with rules and

The

by—laws

to privide

he graduated.

some

continuity

and some dues which could

The restoof the answers are on the form. Perhaps the
meeting could be held in Amsterdam at the International
EEG In September 1977 ? With a visit to Paris at the time of
the course in EEG to Btevenon, or to Basle ? ? ?

first

My

best wishes

Ma

healthy and a successful 1977

.,._.,-r

Sincerely yours,

Pink, M.D.
Professor of Psychiatry
Max

I

�</text>
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January 5, 1976
William E. Fann, M.D.
Baylor College of Medicine
Texas Medical Center
Houston

TEXAS;

Dear

77025

Bill,

Enclosed is a draft copy of the report that I presented
at the depression sessions in Houston early last month. I recall the
sessbons with great pleasure and trust that this report meets the

high standards of your volume.
My

best to Bruce,

successful 1976.

and my

best wishes for a

happy and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

*—‘vwn'ﬂv-"v‘(r‘1r«

,ow—uwmv‘V-‘—_—V'Oi=A-I‘VV‘W

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—.

n

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January 22, 1976
Iver Small, M.D.
Secretary, Society for Biological Psychiatry
Indianapolis, Indiana
Dear

Iver,

First, let me thank you for the invitation to participate
in the workshop on ECT at the WCBR. I thought the session well
attended, the questions excellent, and the presentations served to
alert this audience to the interesting possibilities in ECT research.
Paul met me for dinner that evening and we were able to discuss the
many problems in California and the possible resolutions, which he
may bring up at the task force meeting.
I am writing on another matter as well. For a number of
years, Don Klein has been active in trying to arrange a meeting of
interested learned societies to bring the benefits of biomedical
research to the attention of society. He has alerted me to his
efforts which I strongly endorse. He has asked me to solicit the
support of the Society of Biological Psychiatry.

I enclose his letter to Jolly West, and ask that you
bring up the participation of the Society in this worthy effort
the next Council meeting. I am confident that you will have the
full support of Charlie Shagass and Arnie Friedhoff.
Many

at

thanks.

.nrw.~nm-Wwvm

Sincerely yours,
-

v

nv‘wu

emu

Fink, M.D.
Professor of Psychiatry
Max

M—wm

N...

�</text>
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w wwwn—‘v \‘ny-"vuv'wvnvrw'Iw-w

wu'p.“~“nag-:7... “um...

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v

_

January 22, 1976
Donald F. Klein, M.D.

Hillside Hospital

Geln Oaks, New York
Dear Don,
am pleased that your idea for a consortium meeting on
research
biomedical
is progressing. I have written to Iver Small,
in his capacity at secretary of the Society of Bioihgical Psychiatry,
and have asked his support at the next meeting of Council. Since that
will be in June, if you have need of the Society support before
that time, please write to him directly, and I am confident that
he will act positively, even before the Council meets formally.

I

the

next you talk to Charlie, remind him that you need
support, as he is an active member of the Council.
When

SBP

Good

luck.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>.7

7...?” “my..."vnuw-‘m.w—WWAmmw—mxu—&lt;—-.e-r:.-..m—«~

~u—eww

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,

-

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February 6, 1976

,,.

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mm

”.4,

Fisher
Hospital Practice

Mr. David
hBS
New

Madison Avenue
York City

any

Dear Mr. Fisher,
On

two occasions, endocrinologists of prominence have

referred to articles in Hospital Practice as excellent reviews of
recent work. In answering a question for Dr. Dputhy Krieger,
she also told me of the report in your Journal.
I have checked with our library
available.

and the Journal

is not

May I ask how one can get a subscription or copies beginning
with April 1975 ?
.

Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>H.

r-..

.

mu, .M was» m'so-

tw-‘rrVrv-n www.c—

-.x pm,

-0"va w-ur—a «n mwrw-

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February 13, 1976
Mr. Gary Seidler
Editor, The Journal

Addiction Research Foundation
33 Russell Street
Toronto, Canada
Dear Mr.

Seidler,

For a number of years, I have subscribed to the
During
this time, I have watched the scientific quality of
Journal.

the reports deteriorate, with the report by Ms. MacLennan, describing
an interview with Dr. Eugene LeBlanc, the latest low point for opinion
without evidence.
At no point in the report is there any data presented. One
tell if Dr. LeBlanc is a researcher, admonisher, or administrator;
and if he is a researcher, I cannot find a clue as to the type of
work that he does which Justifies his opinions.

cannot

It is sad that the newspaper of a research organization
serves to print opinions without basis in fact. The issues regarding
cannabis are controversial, and we seem to need more light and less
heat. I wonder if your office will try to report the transactions
of the recent chronic cannabis use conference in New York; or the
results of the Greek study of Stefania and Dornbush (a copy was
sent to the Foundation last summer ); or the 197% meeting sponsored

by NIDA on cannabis

?

I fear I shall not find out, for I
to
subscription
lapse. I am disappointed.

have allowed

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

rwww

�</text>
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                    <text>February 17, 1976

Doris H. Milena. M.D.

Professor

Department of Pediatrics
Dovnetate Medical Center

BURY

Deer Dr. 1411mm:

All subjects with e chronic history of cannabis use were included
in the sample. Both subjects and controls received the some inquiry and
none of the users rare excluded for neurological dysfunction. Exclusions
were: over age 58 (h); concurrent heroin uee (3). alcohol use (3); and
amphetamine use (1).
.

a

:
-

w

"Saw—sz'rl‘warvmnwum‘m‘

v

In our neurological reviews, we bed h subjects in the user group
in the control group with abnormal EEG. or both groups, heed injury
within 3 years was present in 2 users and 1 control, and in the users, these
two were the only subdecte with an asymmetric EEG record.
and 6

The study was undertaken on the invitation of Professor Mirna
who referred 28 cases to us. He cooperated in the study supplying the heehish

used in the acute studies.
and

EEG

We

failed to confirm his preliminary observations,

he is satisfied that the original reports were based on poor
recordings and clinical global aeoesemente of organioity without controls.

I believe

The principal differences between users and controls are found in
tolerance to heehieh, some medical findings of a non—specific nature, and
in social factors (After all, users persisted in criminal behavior - buying,
selling, and smoking e prohibited substance ~ despite frequent Jeiling).

point of view, the most important findings were the
brain disease. aggressivity, or social with—
drawal and the positive evidence of tolerance. It turns out that cannabis
substances obey the basic love of pharmacology (re found no "reverse toler~
nude" for example); that it is a remarkably safe relaxant and euphorient.
and in contrast to alcohol. does not elicit aggressivity. Indeed if one had
to select e CNS active drug to use, cannabis is remarkably safer than alco—
hol, opiates and probably equivalent (can one ever any it?) to tobacco.
From my own

negative ones
—

-

no evidence of

The full study will he published this Fall by Raven Press as
Long Term Heehish Use, edited by Stefania, Dornbush and Pink. You may also
wish to read the Reunion study (Qggﬁe in Jgggice, ed. by Rubin and Comitee)
end the forthcoming report "Chronic Cannabis Use", H.Y. Academy of Sciences,

edited

by Deonhueh.

Thank you

fer your thoughtful inquiry.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

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                    <text>f

[fl/jaw

December 23, 1976
Mr. Harry Henderson

Editor

World Wide Medical
880 Third Avenue
New York 10022

Press, Inc.

Dear Mr. Henderson,

is accurate, and I congratulate
you provide. I have a few comments that

For once, the reporting

you on the summary
may be helpful.

that

1. The effect of the Massachusetts reporting system has
been salutary, and the follow up report by Grosser in the
Massachusetts Journal of Mental Health, Spring 1975 could be

referred to.

The report finds that the institutions reporting their
seem to be following the guidelines set by the medical
communitym and such self monitoring is much to be preferred to the
EST

experience

California

model of

legal restraint

and

interference.

2. Leonard Cammer is a curmudgeon, representing the
opinion of himself and a few die-herds. He and-his associates
fail to see that with the development of third party payers, and
government funding, there will be regulation of medical practice.
Whether the regulation is made by the State and external to the
medical community, or by them-edical community is the issue. The
members of this APA Task Force seem inclined to develop models of
education and self regulation and it is probable that their thoughtful
recommendations will be accepted by the 20,000 members of the APA.
I believe you give undue weight to a very minority opinion by quoting
his (Leonard's) very conservative and 19th Century approach at length.
«m

".41:

-

WI7‘F'IYv

A
.

3. Dr Tien is a poorly trained, misguided therapist who
has produced many articles of uncontrolled,'studies'. His approach
is far from the mainstream of world psychiatry and again, you do the
serious students of psychiatry a disservice by quoting his remarks.
Better you should have quoted Dr. Friedberg, a young resident from
Oregon who did present the negative views of EST rather forcefully
in the same session at which Greenblatt and I spoke. The American
Psychiatric Association has decided, that despite the ad hominem
and erroneous nature of Freidberg's remarks, the American Journal
of Psychiatry will publish his remarks as well as those of the other
panellists at the session you quote. I would urge you to relegate

�H.

Henderson..........

December 23, 1976

.......... page

2

to his private world. Incidentally, your references to the
society in the same article as the established society suggests
that somehou, the new group represents the professionals who have
an active interest in EST. That is not so, since few of the
authorities that you may wish to quote and who have carried the
Dr. Tien

new

burden of research these many decades have joined

Cammer

and Tien.

4. Since that presentation, Avery and Winokur, in a
very forceful article in the AMA Archives of General Psychiatry
(33:1029-1037,1976) indicate the importance of EST in reducing the

incidence of death in depressive illnesses. Their findings are
striking for deaths by suicide, but equally for deaths from all
causes. I commend their article to you. Another important study is
that of McCabe (Amer J. Psychiat. 133:688-691, 1976) who finds EST
as effective, and often more so, than other treatments of mania.
The importance of his review is the data that the time for
response
is notably shorter for EST than for drug therapies—— a finding
that
should serve to reduce the mortality among manic patients who frequently succumb during the first week of treatment.
I trust these comments are helpful. While I have good
press photos, I regret that I am of sound mind and do not wish to
have my face presented in the lay press. My opinions matter
little;
the results of my research do, and when someone wishes to describe
my laboratory's work, I would be pleased to supplement the reports
with pictures.
My

regards and best wishes for a successful 1977.
Sincerely yours,

:-:

v...

-u,«.w.'

«n;

«t,»

q'w'

“wry-v

-..

war

:91

1m

ﬂi'jrﬁr

-

..
gun-w.

..

www.myv...

W

Fink, M.D.
Professor of Psychiatry
Max

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                    <text>March 1, 1976

Earl Usdin, ?h.D.
Chief, Pharmacology Section

Psychoyhnrmocology Reseeroh Branch
Department of Health, Education, and Welfare

Fublic Health Service
National Institute of Mental Health
5600

Fishers

Deer

Earl:

Rockville,

Leno
20852

Md.

Enclosed is a corrected copy of my discussion for the Aailomer
Conference. I would be grateful if you would make the corrections
on page: 1 and h, as indicated in this copy.

I

hope

the proceedings are

coming along

well.

Sincerely yours.
Pink, M.D.
Profeeoor or Psychietzy
Me:

�</text>
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                    <text>March 8, 1976

Giuliano Dolce,

M.D.

E. Merck

Darmstadt, Germany
Dear Giuliano,

writing to thank you for your fine care during my
recent visit. I enjoyed the dinner very much, and I am only sorry
that my worries about my luggage may have depressed the party. Inge
took excellent care of me, and I thank you both.
I

am

the airport, my luggage arrived 1 hour before my plane for
Paris, so all was well. ( When I flew from Paris to New York, my
bag was missing at Kennedy and it arrived on a later plane that night 7
It was a wayward bag.)
At

reflection, I agree with the decisions made
at our meeting. Should the new clinical data suggest that a study
with detailed electrophysiology and psychology would be helpful, it
can be organized at a later date.
After

some

I met with Karl Rickels, and discussed the protocol he
submitted. I think he will go ahead with his study and we came to
an easy understanding regarding the IND and the details of the study.
Should Merck decide to invite me to act as their consultant, he ddd
not feel, as I do not, that there is any conflict.
Walter has passed his U.S. ECFMG tests. He is busy writing
two reports, and has received his NIMH awards- so I hope that he will
be able to come back this fall to complete his studies. He returns

to

Europe

at the

Again,

end of April.
my

thanks to Inge and

my

best regards.

Sinceeely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>March 10, 1976

Dr. Lannnrt Klaus

KunsshﬁsIVngn 9
I~260 lh GlumslSv
Sweden

Dear Dr. Klaus,
and

Your

letter of

Just forwarded

to

me

23 Dooembur VI! sent

to

my

former University,

- I regret tho delay in replying.

Following our work on oyelazocine and naloxone, as referred
the U.8. Government actively supported the developmznt of
1971,
in
to
new
antagonist, noltrexnno. This ﬁrm; ho: had uxtonsivo clinical
a
antagonists. Clinical trials
triols, and now seen: superior to earlier
and
the
drug is not yet marketed.
under
auxpioos,
research
are still

laboratories which tested the antagonists found their
difficult. When patients have the choice between methadone or
naltrcxonc. thqy surely prefer mathadone. I bolieve that in N.Y., only
my {armor co~worker. Dr. Riohard Rounick in actively using naltrexone.
He reports good clinical results.
I do not believe thot nnltrexone will be very successful,
especially when it oontinuon to compote with nothadono.
use too

Most

Thank you

for your inquiry.
Binoerely yours,
Max

Fink,

M.D.

Profelsor of Psychiatry

�</text>
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                    <text>March 11, 1976

Susanna St. Pierre

v. 571:1: Street
"Sixty Minutes"
52h

How

York. N.Y.

Dear Mt.

10019

St. Pierro,

I spot. to 9r. Frankel and he luggostod the enclosed in—
foamotion may be of interest. This draft of a report given last
woek will be edited, but the sense of it may provide some
balance in a review.
I also enclosed abstracts from two publications about EST
may assist you in your review. One answers questions presented
clinicians; the other summarizes the clinical material at the 1972

vhich
by

conference.

you well know, the issues about EST are emotional and
politicized. The science tends to get stomped. Mike Wallace, like
Earl Ubell some years ago, has a reputation for scholarship. I
As

you will consider carefully how you prosent the data, and not
inflows on already unhappy state, as did Frank Field a few weeks ago.

trust

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

Max

�</text>
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                    <text>March 11, 1976

Prof. Dr. £1.14. You Frans
Payohlatrio University Clinic
Div. of Biological Payohiatry
Graningon
Tho.Nethorlands
Door Harman.

It

to tend no the imyroasive annual report
for tho dopartmont at Groningen. It is a fine document, reflecting
the excellence of the studies which have become so well knovn.
I

was kind of you

was

pleased to read that you are doing

EEG

research.

You

should know that our facility has been available for
years, for collaborative studios of the electrophysiology of drug
effects. Should you wiah to expand your studies to include power
spootra or period analysis, I would be glad to discuss it with you.
Please change the address in your
Co11ege to the SUNY address above.
my

more than two

files for

New

York Medical

regards.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 12, 1976

thn

ll

Exner, Ph.D.
Beavcr Drivav

Bayvillo, H.Y. 11709
Dear John.

I read the record of G. Trumantelli, age hT. It in an
mixed frequoncy record without distinguishing
amplitude,
average
features. Eypervontilntion and sleep activation were not done.
In the absence of saizure activity or alov wavea, it is
not possible to support a diagnosis of a poat~seizure sta£e; nor are

thnre distinguiahing criteria for a drug effect.

I trust this is helpful.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

m'.-Wbﬂ'r'vwF-‘€-I

nun

-w—v~=»;\wnp

a:
~

w—-—A

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“....r—‘— . u~.——'=.n—»v-——-..m—--w_

.va-WWHW- WWWW-m-.WT— .mu--.My g

May

m.

.....m

'mﬁ'rw- “Feummnww—rw

3, 1976

Russell

R. Monroe, M.D.
6H5 Redwood Street

laltimore,

Maryland

21201

Dear Russ,
Your personal letter describing the opportunities at
the Maryland Psychiatric Institute was most inviting and interesting.

First, as to myself, for that was implied in the letter.
I have no desire to head a laboratory center again, having had the
experience in Missouri and finding that the administrative load kept
me from the studies which I enjoyed more.
best of

The

my

students are recently placed in

new

positions.

Jan Volavka, M.D. has just taken a position in Missouri, in my old center.
Michael A. Taylor and Richard Abrams, both excellent researchers, have
just agreed to go to the Chicago Medical School.’
The ones who may be movable and who come to mind are
the following. Turan Itil has set up a large center in New York at
the New York Medical College. But funding is quite difficult and if
he could be assured of 'hard money', he may consider such a position.

Recently, I met with Jerry Tintlenberg in Palo Alto. He
researcher, but probably does not have enough experience
to take Al Kurland's place.

is a bright

young

Donald Klein has resigned from Hillside and has expected
an appointment in the Albert Einstein College. But Ed Sachar may be
moving, so he may be up in the air and may be interested in a lab

with 'hard money'.

These are the only three with whom I have had some personal
contact during these past few months. I shall keep the opportunity in
mind, and if another candidate comes to my attention, I will refer him
(her) to you.
My

best regards

and my thanks

for thinking of

me.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mal

.

,._..-..

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                    <text>4:345”

May 11 ,

Marguerite T. Hays, M.D.
Medical Research Service

1976

V.A.

Washington, D.C. 20h20

Re:

M.

.

David

Fairchild,

Ph.D.

Dear Dr. Hays,

his co-workers

I cannot eecall meeting

Don Genden

and Dr.

Dr.

Mickey——

Fairchild, but I

the

latter

have met
serving as an

ad hoc reviewer of one of my NIMH grant applications. I do know their
work well, and have followed
will interest. They first published about
1969, declaring that the effects of drugs on the EEG of cats could be

it

distinguished using multivariate statistics, particularly that they
could identify different drugs by this method. Tley proceeded to
extend their work with a predictive study and were successful. Since then,
they have published occasionally, and I am not acquainted with any systematic
body of data or systematic applications.
Their work was unusually well detailed; their statistics
was exemplary; and they held a promise for greater applications, particularly
in studies in man. The reports reflected peofessional knowledge of EEG
recording and

statistics.
It is difficult for

me to parcel out the contributions of
therefore to assert what Dr. Fairchild'd
unique, personal contributions may have been. If a number of his reprints
were made available or brought to my attention, I could possibly evaluate

each of the

them in the

participants,

and

light of the developments during the past decade.
I

trust these

comments

are responsive.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

‘

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                    <text>»-

—v

.uww

w'ﬂ-uw’wr-

V.

-7. A...

.a-.--..

w...—.—,m—.-nm,—.~-mm~a..—-—m-w.————-m‘—.—

May

-

-d

8, 1976

Prof. Dr. Tetsuo Fukuda
Neuropsychiatric Policlinic
Doshisha University
Kyoto, Japan

m‘w-

Dear Professor Fukuda,
-,,.........,.,.,.

.

.
..y~—-W-

mamw

..u...w.'w

mwmwcuw

mW'

-—1

mun—r

__,_._,

g

.7-..

It was kind of you to send me the reprints of your
work in lectroseizure therapy. I found the papers of interest
and am pleased to become acquinted with a body of experimental
work that is new to me.
Professor Jan Otto Ottosson has acdepted the responsibility
to develop the panel on EST for the next World Congress of
Psychiatry. I will write to him shortly and shall bring your
contributions to his attention.

It was indeed good fortune that arranged for me to
meet Professor Mitsuda on the sands of Waikiki. I have spoken to
Professor
this week and told hfm of your letter and my
meeting with Professor Eisuda. He recalled the meetings in Kyoto

Itil

with great pleasure.

,,
.
.7.

v

in

I do hope that we
Hawaii next year.
My

regards and

my

will be able to get acqauinted (again
'

thanks for the papers.

Sinciunly yours,
Fink, M.D.
Professor of Psychiatry
Max

7)

�,...

v-um-wvung

7

w-W—lr

“—VW

.

"haw...—......

.pmmwy was—Wu--.~avm muw'mw‘w-W _‘

May

7, 1975

Professor Hisotashi Mitsuda

Osaka Medical College

Osaka, Takatsuki, Japan
Dear Professor Mitsuda,

It was a good fortune that arranged our meeting on the
sands of Waikiki, and I thank you for the recommendation to
Dr. Tesuo Fukuda. He has been so kind as to send me some of
the reprints of his work, particularly the work in electroseizure therapy, and I am pleased that these have given me a
better idea of the excellent work that has been done in Japan.
Professor Jan Otto-Ottoeson of Sweden is organizing
the panel on EST at the forthcoming World Congress of Psychiatry
and I have sent him the suggestion that Dr. Fukuda be consdiered
among the participants. I am sure that he will let Dr. Fukuda
know directly of the development of the panel.

I look forward to meeting

you again in Hawaii in 1977.

Sincerely yours,
a.
.
..
.

‘mwrmmmnwwm

.-v-~

\
rwv-

WWW

"pm—Wu.

».~.w.w—w_.—w—

Max Fink, M.D.
Professor of Psychiatry

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1","

m..-—.-_-»-...w- W,—

m.‘

e. \e— -. unaware“ .uﬁw—‘u-“emnn’- Y...“ «an m. e: "—wnw—rwv‘“w‘—'ew u.

—.,.

.V

"-‘a. “u. ‘,__.___._..___....._.._...4

May 17 ,

“.7.

.

.4

1976

Dr. Laurette Banter

#23 Ben Oaks Drive

W.

Saverna Park, Maryland

21146

Dear Dr. Bender,
The American Psychiatric Association has established a
Task Force on Convulsive therapy and as a member, I have been

literature for a statement of the efficacy
in a variety of conditions, including the
treatment of childhood psychoses. I have been referred to your
work as evidence of the usefulness of seizures in children and
have found it difficult to find the citations. I would be
grateful for any reprints or reference to published material
that you may have available that may assist in this effort.
asked to review the

and

safety of

EST

Dr. Hegeman was kind enough

she, as do 1, sends her regards.
Many

to give

me

your address and

thanks.
Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

�</text>
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                    <text>mm—wmmWw—«Www

9w?”

May

Professor Dr.
9

22, 1976

Mitsuda
Kitazono-cno, Shimogamo
H.

Sakyo~Ku
606 Kyoto Japan

Dear Professor Mitsuda,

It

of you to send me the fine volume of the
biological bases of metal illness, held in Kyote.
I had heard much of the conference, not only the excellence of the
papers and the discussion, but the generosity and hospitality of
was kind

1973 conference on

the hosts on Kyoto.

psychiatry,

is an interesting milestone in biological
shall treasure it in my library.

The volume

and I

I thank you for your thoughtfulness.
Wm—n-m.

&lt;

Sincerely yours,

xwvwW

w
9‘!

aw,"

..
a.

.,....

n..........,.7v.s...

,..
Nu

.1.

~

pr...

‘.

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Fur...

,

....

W.

_.

,

_

'psz «wsvrv

«or try—WW. _

ﬂu”.

.

.,w--. nun-v -u

N

‘

7 . Fl, u~murwm~wu~um

‘1

‘

.mw “..meﬂy- 'wr‘l ”may._ .Yﬁvm’wmxmu»...n-r-—~»—.—--—W"'*‘W
.

-

th 25. 1976

E

William Dent, M.D.
A.H. Robina Co.
1&amp;0? Cummings Road

Virginia

Riohmond,
Dear

Bill.
I tried to find

Dr. Tisdalo at the Florida meetings of
are interested in continuing studies of
2277 and woula be grateful if you would send me the
latest
‘

ECDEU,
AER

23220

but failed.

invontigator's
my

W;

summary and proposed

protocols.

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                  <elementText elementTextId="103947">
                    <text>Flown. v'v—wur ...

~~. -

,

-

...\

-——

wwn-v-IyV-V‘wv‘ﬁ'mwrxt—I—r-m

i.

v.

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v

w "—wwpa- -W4.-——.-W-w.

mom—“Tn ~y-wmm~~.—&lt;

'vn

.
'w

wun~«m_n.v-.~

May

Joseph Jeffe, M.D.
Dept. of Psychiatry
College of Physicians and Surgeons

Columbia University
New York. N.Y. 10032

27. 1976

if

Dear Joe,

about

Thank you

my

for your recent letter

visit. I did

another opportunity to meet the

merit, that of

EST.

While

and

the nice

comments

enjoy the session and hope that I will have

at the

APA,

I

staff

on the other

had an opportunity

issue of

some

to chat with

Dave

is actively involved in studies of lithium maintenance
in a large clinic, He tells me that he has therapy responders and
non-responders, and the paper he geve on this subject was quite good.
I suggested that rather than having you relate to me at LIRI, with

Dunner.

He

all the distances involved, would he not prefer to work out language
measures as change scores and even as predictors of response to
lithium? He seemed delighted and I commend you to him. As I know
him, he is an earnest and herd worker, quite forthright and honest,

”vand

I

would be delighted

to

work with him.

If I can be of further help, let
collaboration works out.
My

me

I

know.

hope

the

‘

best regards.

Sincerely yours,

m:

Fink,

M.D.

Blp£. of Psychiatry

—»

-—-

mm.“

�</text>
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                  <elementText elementTextId="106991">
                    <text>7.“... _,_ _ WW.

”“2 ..., v. - w. .,.......,.—-. ,r.

.....\r..............

»-~m~-:—w‘-z--r-—.m

”av—"WWW”.

-.,,1. .— q...

.- _.. ...

.

e,m .

..

,g

w...M...a.“ w. .

v.

May 27 .

.

-

...

w.

.

..

.7

”.7.

..

..

.

n...

v”

Dyna—um,

.—,...—..—.\...~"WW", .7...

,vv

.

...—.--....r...._.:vr

1--..”—

1976

Dear Stan,

It

has been some time since

is well in Baltimore.

Our week has

communicated.

we

fallen into a routine. I

I trust all

had a research fellow

Italy with me this past year, and he has left. He stimulated
our interest in anticonvulsants and we are now studying these actively.
from

We

year.

The Greek volume

I am,xeeting another
We

studies and demonstrated
studied. We think EEG can

have completed some blood level/EEG

the very high correlations for the drugs
be used where blood measures are hard to

are developing

is about

60%

on EST.
some

we

come by.

done and should be out next

ties to Hillside Hospital.

Enclosed

is a paper sent me by one of their staff who is interested in Joining
BURY.
I cannot evaluate the merits of the thoughts or processes. Can
you give me an informal opinion of this work?
Joe invited

He's looking for
My

new

me

to

P 8

for a lecture

challenges, and so

em

I.

and we had e good time.

best regards.

J

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

\

�</text>
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    <fileContainer>
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                    <text>May

Dear Dr. Goldfarb,

Enclosed

is the reprint you requested. The problem that
APA is an important one, deserving of the

you addressed at the

detailed

and

28, 1976

controlled studies

which have become the hallmark

of recent research efforts in this country.
of

my remarks was in part occasioned by the
Task Force on Convulsive THerapy held earlier
heard from a number of EST practitioners that they

The burden

hearings that the

APA

that week. We
were uniquely successful in

treating thousands of patients without
succinylcholine, barbiturate or anesthesia, without memory loss or
other discomfort, without missed seizures or panic or failure of
patients to return to treatment. In tine with that experience, your
anecdotal report seemed to be of the same nature—- observations
without a comparison or control group, and without evidence in
the report of detailed attention to the problems of consent by
psychiatrically ill to procedures that are clearly experimental.
Further, since you were willing to push the limits of the number
of seizures beyond those in the literature, it seems essential that
peer review of the protocol be included in the report. If there was
peer review, then a comparison group would have been essential; its
lack suggested that peer review was cursory and perfunctory~~ surely
not acceptable in a procedure as potentially damaging as induced
seizures.

One other point-- your text suggested that the increased
frequency of seizures was an attempt on your part to reduce hospitalisation in a situation where you were overwhelmed by a large number

of patients and an inadequate number of personnel to care for them.
This is an inadequate justification for a research effort unless
duration of hospitalization and aftercare are part of the project.
In the report, the use of drugs after and during EST seemed uncontrolled
and therefore to nullify the significance of your observations.
There is need for a controlled study of multiple EST, and
I hope that you will undertake such an effort-— with regular EST as
a comparison group, peer review of the protocol, and consent procedures
that are well defined. Good luck !

Sincerely yours,
Pink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>MW~

~ w—"q—w—gw

-»-.

rw-vww

"vu

__.‘.

.
"gm-"w

.1» w.

k

August ’4. 1975
Ms. Maya

Pinea‘

h72h 32nd

Street,

washington,

N. w.

20008

Pines,

Dear Ms.

m.

D. C.

for alerting me to the latest issue of Saturday
to the fine article that you wrote. It does capture the
excitement of our work. ORG 2766, the long acting peptide. will be in
clinical trial in Europe and the U. 8. this winter. It is going through
human toxicology trials now. Among the early tests in the U. S. will be
assays of its effects on the EEG and on memory function, and in elderly
patients. The studies of ACTH h~hlfin the elderly are in progress now
at New York Medical College and Néw York University, and soon will also
boast the Hillside Hospital in New York.
and

Thank you

Your

article was well written

and described the state of the
you.may wish

art well. Perhaps, among your other writing assignments,
to tackle another interesting story.
The human EEG has been

studied since

its first

published

report by Hans Berger in 1929. During these hs years, there have been
many applications, including some of those described in the Saturdgy
Review. One interesting development which is not widely known is the use
of EEG methods to find new drugs for clinical psychiatry. Since the first
descriptions of modern psychoactive drugs in the early 1950's, most cons
pounds developed by industry are based on their similarity to an ettablished compound, or to their effects on animal assay systems. The first
methods produce "me, too" drugs; the latter are often inaccurate, for
someilIuInnds that are psychoactive do not satisfy the animal assay
‘

criteria,

useless.

and some compounds

that

meet assay requirements are

clinically

quantitative EEG analysis has been successful in providing
a classification of psychoactive drugs that is based on neurophysiologic,
The

not on chemical criteria; and new psychoactive compounds have been found
by these methods.

�‘V’nwr

wuss-r:

r‘wr‘l-YW'

V

7.77 ._

.. nu war

WWW‘IC'W‘wummmw—VVnruwman-rm—w

"1. war "W"‘m‘ -wn.w.~A—a-.r-a—mm.w~rnrw—qw—~nwr-sm—r—mvw

M's.

Maya

,

g
i
-

rmr-~

4

—:.-,

W;

cm.

y!"7!f‘l‘7"*‘

.

qmiuvw-prw—u.—

-—.-1-.-

wmawW..—V.w-ywu-.m

Slit/75

-*

EEG methods hare also been extended to estimates of the half
bioavailability of drugs. This latter use has become important
as the FDA has demanded that drugs from different manufacturers meet
stringent standards of safety, purity, and availability to the patient.
These studies show an intimate relation between changes in
brain function and behavior in man. Some physiologists describe the
electrical activity of the brain as a 'matabolite' of brain function,
reflecting its underlying activityh.
The quantitative analysis of EEG is distinctly different from
the clinical analysis of EEG.as is ordinarily done by neurologists. It
depends on careful control of the setting of the experiment, and measure—
ments or the EEG, using digital computer analytic methods. A review of
these developments would be timely, for it will provide the lay reader

life

E

Pines

m—N

and

with another

View of brain function to complenont his information of
depth electrodes, chemtrodca, biofeedback, and sleep research.
-

.

I

am

enclosing two reprints describing this work, one for
that may give you a better idea of this topic.

1969, and one for l97h,
Again,

have an opportunity

congratulatiOns on a fine report. Perhaps
to meet'to discuss this interesting project.

my

we

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Max

MF/mr

Enos.

will

,

7

Wm, e..-

um

v.7. V...”—

__

�</text>
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                    <text>-

ewewwwm.

q...—

V...

,

Ausust 7 . 1975

.—

Wm.”

lvwrwmr

v—mrvqum

-

r

.wm

Ivan

W.

Sletten,

M.

D.

Professor and Institute Director

School of Medicine
Department of Psychiatry
University of Missouri-Columbia
ShOO'Arsensl

Street

St. Louis, Missouri

63139

Sletten.

Deer Dr.

I am replying in a formal manner to your letter of inquiry
regarding Jan Volarka, M. D. It is not clear for what position he is
being considered, but he is an excellent candidate for the position
of Director of the Institute.
Dr. Volsvks Joined

~College in the £311 of 1968.

staff at the

my
He came

medical
as a well-trained psychiatrist,
New York

neurolOgist, and electroencephalographer, with extensive research
and
experience. Within a short time, he established‘collaborative When
independent research projects in the areas of his competence.
I left the College, it use a pleasure to recommend him to assume
responsibility for the EEG programs of the Depehtment.

In addition to mastering the English and Spanish languages that are necessery for his work in New York City, he has become
fully‘sccredited in psychiatry by the American Boards and has become

licensed to practice in

New

York.

Dr. volevha is a keen researcher, well read and well
trained, capable of independent and collaborative research. He is
an excellent statistician, in addition to his training es s physi—
cian. He is well liked by his co~workers, is able to establish good
relations with patients, and an excellent teacher.
,

�“we...” , ".1. ,F....._,"rm..v——“m.1

.

.-

-

v. _ . ...- "vow-n.

,..._.

w; ”Av-.3“.

arr—v, --——~—~-—r-”nun-‘4
V

.

.-

a WWW'”v.w“ﬂung“. 4

Mn;

r

4.w wan—«T. ﬂew -»a um u..."a»

‘1‘.

-WW—«.—

,
4.,

.

r
A,

,
_,

«Trump—y;n..—‘mriv.,,,ne.l.,

w‘rivl'vm‘ﬁr

w

urn:

a

inr“

Ivan

Sletten,

W.

M.D.

-2-

.

8/7/75

we have published together. and in this relationship I
him critical, independent, and e perceptive student of
found
have
the literature. I know his family, and while it is difficult fer
me to conceive that his wife would be willing to share the rigors
of St.Louis, she is an outstanding student and athlete, being a
world champion in tennis and skiing. He is personable, Joviel,

herd-working, sensitive, and enthusisstic.

He is an outstanding‘candidete for the position.of
the Institute and I commend him to you for that posiof
Director
deem it an honor to hive him assume the title which
would
tion. I
I relinquished some years ago, with the'full knowledge thatofhis
training and experience would serve to carry out the type
clinicel—electrophysiologic investigations_for which the Institute
has become known under the aegis of Turen Itil, George Ulett, and
myself.
.

.mv-«W._—~.~l_m,_..i

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

*1!

�</text>
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                    <text>‘7": ,.._..v_

Auzust 8. 1975

Mrs. Marilyn Freedner
28 Strathmore Road?
Great Week, New York 11023

~

‘
\K‘J

i

Dear Mrs. Freedner,

I thank you for your
gagigg orticle.
So

comments on

the Saturday

far, the experimental peptiies are in trials in

seizures (convulsive theraPY) and
in elderly patients with 'normal‘ forgetting. Should these

patients

fOIIOVing induced

continue to be successful, I have every expectation that the
experiments kill be broadened to other population samples. For
the mnenwhile, the rules of drug research prohibit trials in
individual patients with disorders outside those for which

trials

have been approved.

Sincerely yours,
Fink, M. D.
'Professor of Psychiatry
Max

;

hFer

�</text>
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                    <text>August 11 . 1975
Mr. Edward H. Meyer
135 Godfrey Road
Fairfield, Conn. 06h30

Dear Mr. Meyer,.
comments have

receiving

ECT

for your inquiry and for letting
in the Bridgeport Post.
quoted
bee.
Thank you

The memory

me know

loss which has been described in

some

that

my

patients

'

can be reduced by a number of maneuvers: the proper selec—

tion of patients for treatment to include only those with depressive paychoses; the proper placement of treatment electrodes; and the treatment
of those patients who do experience memory difficulty with new, memory
enhancing peptides which are now in experimental study. It is not clear
from your letter whether you are asking about treatments to be given
(where prevention is available) or treatments that have been given
{where therapy is limited).
'

Treatment for any illness is not alggys effective, end so
with
convulsive
is
therapy. In comparative studies of ECT and drugs,
it
“the treatment results, even accounting for memory effects, are uniformly
_better for certain types of illness than when these patients are treated
by drugs or psychotherapy.

I do not know what declarations others may make; in my lab—
oratory patients and their family memters are advised as to the limitations and possible advantages of any treatment we may undertake, and consent is obtained from patients and their kin.
Medical custom.is a much stronger inducement to medical
practice and behavior than your reference 'under law' since the law is
what the courts and lawyers wish it to be; medical practice is respons—
ive to the ethical standards and morality of the community in which a
physician serves, and the hazards and pressures of the informed and

laity.
I trust these

uninformed vocal

comments

are responsive.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF/mr

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                    <text>kW

'

August 21, 1975

Fritz A. Froyhan,
Editor-1n—Chief

24.13.
J

Camprehonsivu Psychiatry

washington, D.C.
Dear

.

f

20009

5

Fritz,

E

Ed's

letter of

August 12

is in error. Chnrles

Shagass in program chairman fbr 1976.

with his carbon,

i can't

Since no

latter

cans

to the

i

i

nnavnr.

Whatever happened

i

.

book reviews!

—&lt;.v&lt;r‘.,,v_.",

My

v

Nov—.0.-.—

regards.
Sincerely yours.

vm

_‘

Fink, M.D.
Profbssor of Psychiatry

Mix

MF/mr

�</text>
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                    <text>Maw—WW,

w.*m,wm\w_

"em—,m—m»..u—.w—....,..

g, ﬂﬂﬁ"

u

r"‘("—."Yulrvaw

3—H-”

‘

Alvin 8. Bernetein, Ph.D.
Associate Professor
State University of New York
Downstate Medioal Center
Department or Payohiatry
hso Glarkson Awenue

Brooklyl,
Dear Dr.

New

York 11203

Bernstein,

quentifioation method is preferable to eyeballing,
outline in your letter of August 6 seems quite
the
sophisticated. I think the method will show changes in brain funcof your system, you
tion, should such changes occur. As a test and
closure and hyper—
could establish the effects or eye opening
show big changes in
should
two
thst
simple
procedures
ventilation,
EEG. If these are shown, then the method any is useful. If these
are not evident, then I dug-eat you try some other system.
a research
It is not possible to predict the actions ofmovement
behave
Brownian
or
like
seem
to
committee
they
grant
the random discharges from outer space, but the methods you outline
are not 'gross or simple—minded'.
and

Any

method you

-

Good

'

luck!
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/mr

Yum” .F—m—n—w‘wﬂpr...“

�</text>
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                    <text>wrﬁm

-.v-~v

&lt;u.”yv-v"~vr~v‘

”Rm-unm‘p‘,w-ww-.. “mm"."wv. ,....—.—_,__.,._m-.~.~.«n ,.
——-

September 8, 1975

Stovnn R. Hurnad, M.D.
College of Modicino and Dentistry

of

Nov

Jersey

Rutgers Medical School, Dcpt. of Psychiatry
Univorlity ﬂhighta
Piocatsmuy. New Jersey 0885h
Dear Dr. Harnud,
We

in the

would be planned

Amnrican

EEG

may do your

rccommnnd you

for

mamborship

Society.

«would you

I

to

please Iond.mo a capy of your

CV

to that

record Justice.
Sincerely yours,
Fink, M.D.
Profossor of Psychiatry

Max

MF/mr

�</text>
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                    <text>September 9, 1975
Mrs. Judith A. Cooper
19 White Cliff Lane

Neseonset,

New York

11767

Dear Mrs. Cooper,

misunderstanding. At the
time that Mr. Irwin interviewed you we had not yet clarified,
whether the position would be part— or full—time. That has since
been clarified, and the position that is available is full-time
at-the Long Island Research Institute.

I regret that there has been

some

we have advertised in Newsday this past Weekend and we are
in the process or awaiting replies, which will be reviewed by
a committee, and those candidates who seem to meet our criteria
will be interviewed.

now

Should you'wish to be considered for a full~time position,
I should be happy to have your credentials reviewed, among the
others, at the committee's meeting next week.
I hope that the facts are a sufficient explanation for any

misunderstanding which

may have

occurred.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF/mr

�</text>
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              <elementText elementTextId="61052">
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              <elementText elementTextId="61053">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="103941">
                    <text>,

-

-

.

v-v—ur—w-wv-‘.v—.~.--1W_..w....~. "mun-..”

ﬁr“..- .—nw.-...w,...,

.....m~~«_ :....r-—w-v...w.m.n.w..e.._....._.w....v.

“V"...

.—w.7

.,,

.....(“chit-mn,_1~..r..~..-.....

w

e...,... .._._..-w_ -. ...

—

.r,

..

m.

September 16, 1975
John

J.

schwab, M.D.

University of Louisville
P. O. Box 1055
Louisville, Kentucky

140201

Dear Dr. Schwsb,

Nikolovski,

I

am
M.D.

pleased to write e

letter of reference

on

behalf of Oliver

Oliver Joined my staff at the New York Medical College about 1968.
after his training at the Missouri Institute of Psychiatry with Professor

Turns

Itil.

'

,

Dr. Nikolovski was assigned to outpatient clinical evaluations of
psychoactive substances at the Metropolitan Hospital. The initial exper—
iences were difficult, since the population was largely lower—class and Spasish—spesking, providing all of no with serious handicaps in the evaluations.
Oliver did well. however, and became a principal assistant to Dr. Jovan Simeon,
the unit leader. Together. they completed evaluations of some antidepressant
and antianxiety compounds in these outpatients.

new

V

In 1970, the Department chairmen, Dr. Alfred Freedman, asked that I
transfer Dr. Nikolovski to a newly established community clinic, where he needed
a principal psychiatric therapist. He has continued to do yeomen service at
the College in this position.
Lately, he has been helpful in evaluations of a putative memoryenhancing compound, studies that have been undertaken by my co~vorker, Rhea

Dornbush, Ph.D.

Oliver has extensive clinical experience.

He

is intensely loyal,

dependable and reliable. He is meticulous in his relationships with the staff
and the patients. He is personable and likechle, although at times he appears
ohseqnious.

training qualify him for that posi—
tion described in your letter as functioning in an outpatient clinic with 255
of his time dedicated to research. It is a pleasure_to recommend him.

I believe his experience

and

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

.

.

�</text>
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                    <text>;-—~-Fw—v—.mvw

»

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.

.v.

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.7..\

‘_

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..-v»-~

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MW

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7

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ScpteMber 18, 1975

yr.

Homer A. Chamberlin

’Dundoe, Oregon

97115

Dear Mr. Chauberlin,
The procedures you request on behalf of your wife are in
experimnntal trial in rolativnly haalthy and uncomplicated aldnrly

pat‘inta at this tins. Should the results show the compound to be
safe and have thornyeutic value. it will then be tested in more
severely ill patients.
I truly ragret that we do not have thn facility to treat
wife
at
this tiio, nor do I envision such facility earlier
your
than late in 1976.
Thank you

for your inquiry.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF/mr

.

V..- “ma—~77 V...

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                    <text>WP”

L‘s.“—

(r v—A»!

um

\WWA
,

,

mm-

,

,

mm“ mm“ w-Y_-an.
. », —

‘

_.

v

,. ‘ . .wm.yawma.wvnwm

"Maw“. _ . ,V »/
,

,

....~.

.9- ‘7-“

\

F

t
F

i;

E

!
k
E

E

g.

Soytenbor'BO; 1975

McAllintor, M. D.
Corresponding Socrntary
Amarienn Board of ElectrOencaphnlography, Inc.

M.

A.

.

3101 Kyle Awenuc North
Golden Valley, Minnesota 55h22
Deni Dr. McAllister,

I am pleased to-support the application of
as a qualified olectroencaphalogruphor.

Dr. Gerald Perry

I have known of his work for more than 20 yours, for ha
was Ictivn in clinical practice of psychiatry and EEG shah I firat
can: to the Earth Shore of Long Islnnd. Kb is a fin. clinician,
and an excellent neurologist; A: part of his practice, he has maintained an active interest in cliniogl EEG, being one of the principal
consultants in our community.

Lately, I have collaborated with him in a research atuay
in which EEG mcaauxes are integral, and I havn found his Hork.most
helpful and his cooperation axeellant.

I

recommond him

vighout resorvution.

Sincerely'youri{*'
Fink, M. D.
Professor of Psychiatry

Max

MF/mr

�</text>
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                    <text>r--vv-r—.~.v—-w~v~“

mywmvnz

W”
Michael Taylor,
Max

Fink,

M.

I

D.

am

sorry that Abba turned us dean for he is the most
in the field. However, nyle Miller is a pleasant,

&amp;ynamic worker

friendly researcher who

,and has done
‘nature.

H3

October 3; 1975

M. D.

is

came

to psychology late in his career

interesting research from a psychophysical
a careful worker but does not have the sophistica-

some

tion or the experience of Kastin.‘ I don't bclieve that he would
interesting as Dr. FlorﬁHenry who.apoke

be as challenging or as

today.

‘
»

I think I
~.v-

In“

i
L
E

E

MF/mr

would pass on

this invitation.

‘

�</text>
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                    <text>Joseph Zubin, Ph.D.

Chief of Psychiatric Research
(Btamotrics)
annrtnont of Mental Hygiene
New York State Puychiatric Institute
722 What 168th

new York, H. Y.

Dear

Street

10032

Joe.

I think thn volume, "Contemporary Sexual Bohsviar"
should be issued in paper-back. It is a well~collectcd not of
onuayn, not supersednd by recent rasoarch. The topic is of
perennial intoreot. I asked the advice of our resident anxologiat,
Dr. Richard Green, and h. thought the valume of sufficient merit
to be reissued.
should

(Incidentally, he is not a

v. propose him?)

mambcr

of tho

APPA

-

Congrntulations!
Sincerely yours,
Max

Pink,

M.

D.

-Pro£ossor of Psychiatry

NF/mr

�</text>
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                    <text>October 3, 1975

Fred Quitkin, M.-D.

Hillside Hospital

P. O. Box 38.
Glen Oaks, saw York Ilooh
Dear Freo;
5/?
Enclosed is a copy or the 1976/77 Program Statement and
Budge£?Requcst for the Division of Therapeutics of the Long Island
Research Institute. I think you may find this useful. The program
is set up so that we will develop all five laboratories of this

division during the next four years.

entiinterest butIthese

theiprogram.'
.
.

,

W

whether

I

The
may be modified by
"

on a more personal

knew a Enr. Fred

matter,

my

Quitkin" and

missions reflect my presthe scientists who Join

wife asked

when

me

yesterday

I said I did, she told

that your son.£s in her class. He's quite a charmer and she
looks forward to ﬁeeting you when you visit the school.

me

u.

.

‘\

'My

A

,:

regards,

“5‘ij

Sincerely yours,

v...“

.

/

l

i

MF/mr

Enc.

{1

K.

Fink, Me Do
Professor of Psychiatry

max

r

*

�</text>
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                  <elementText elementTextId="103936">
                    <text>{I

WV"

.

rm"...

rm»

.mrwww-

..

Vt.-.“

,.

.‘

._

m

"

"V

‘w WW
‘

‘

‘

.

H.

"" “'

r'

-

‘

' '4‘ .JG"

. N

_

,

v'

-“Hm"ﬁ"z'-~~~~"v-v-j‘1-rr.‘ w?
_

.

w.

v.‘

. sun»,
Wu'hrwy'm-Vw
.

.

,- 4

.-..~..

.

.

“w. w

y.

W74.“
_

mm m may.

V-

Octobor 15, 1975

Carol Chrintinnlon. R.£EG.T.
Lib. lourolngical Institute
168th strut
won
no

EEG

Rev York, N. Y.
Doc: Minn

Christiansan,
Tho

fbr

EEG

10032

Mbtrapolitan

technicians has
I

EEG

boon

wallnttor 1ndie:tcs that a school

establishcd at Prosbyterlnn Hospital.

would be gruﬁotul

tbr ‘ny description of tha course,

requirnmnntn for adminsion. and vhother the course 19 part-time

at full—time.
Thank you.

Sinecrcly yours,
Fink, M. D.
Profbasar or Piychiatry

Max

HT/ur

�</text>
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                    <text>w... .y.

v-

-n-r 41"":var—-.-»-

‘-'."l-W-»~-wn1—

vawl-Vr."wanna—mm

a“‘|&lt;'&gt;V—-—'V'—-wlr-WW'V‘VWWW‘thru—IW‘

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,

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WM”

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rum.

4.

October 16, 1975
‘ﬁ-VPFEIWm-vrw‘

v.
&lt;

.

Richard

m

V.

.J

M.

Suinn, Ph.D.

Professor and Associate Rhea
Depertnent of Psychology

'WW‘

caloriﬁc 8$e$e University

ibrt Collins,

vs

Colorado 80521

r--r‘&gt;—'1.I$Vt

WNVr-‘v

Deer Dr. Suinn,

In checking
you requested pernieeien

my

records I find them e few years ago

to reprint

one of our papers on

narcotic

entasoniate in a volume ”Innovative Therepiee: Critical Contri-

butione."

I don’t recall seeing the book,
ask whether
whether

we

and

this publication did indeed appear;
may have e copy for our library?‘

I

em

and

writing to

if

so,

Sincerely yours,

ma, “0of D.Psychie$ry
m
Protester
MFYur

‘

~wﬁ

w...

.V,

“7......

w

�a
‘
‘

‘

r v.

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w—.

~v.

nun-7r,-

"urn-WWIV

v.
‘

&amp;

am..."

V

”wwwmmmﬁ

WW...

v

785-5055.

January

236th, 1973

8m.

31311“ M.
Phoni.
Profbcsor and Assaults: Head,
Dapurtnpnt of Piyuholoar.
Colorado

Silt: university.

For: Genius.

001m

30521.

Dear Doctor Evian,
Hy associatns :nd I are planted that you tr.
‘.
considering our report tar tn: boat of readings titlad
”Innovnxlvn Therayict: Critical Contributidns”.

I u: enclosing sh. signsd rolonn¢

of tun rcprint you requastcd.

and two coping

Since that report‘vna written v: have updtted our
axpcricnco. 3nd I nu enclosing Eva c0910. of thc latent
varsion of our report on these therapies. This varslon
has beau Iﬁbulttod tar pdblieatian, but has not ynt
tpwoarcd. I an canfidnnt that v» cgn dbt;1n s rolonso.

I nut. thaﬁ you ac not considnr ruyultioc 2b:
aur contribution. at the laalt I would oxpcct an editor»
ligand cony of the final publication for each of thy authors.
I trust that thin vauld‘bo’ponutble.
While

Singercly yours.

Mn:

rink.

M.D.

Profoaadr of Paychittry
10/13

Incl.

�</text>
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October 16, 1975

m-wecv-

r

.V-

Int"

«W‘Wzr‘

r—uy

.

Millicent K. Trnchtcnborz. Administrator
Ficldston Lodge Huruing Hour

Ks.

666 Kippock garnet
Bronx. ﬂew Yomt 10h63

Dear Ma. Trachtonborg,
Mrs. Bonus Durbin scrvad as a research nurse in the
York Modicnl Callas; Division
in Motropolitan Hospital from ayproximatcly 1969 until I left in
1972. Thereafter. she eontinnnd to sorv. my successor, Dr. Richard

ansrtannt of Psychiatry :3 thn‘lcv
Rnsnick.

I found hat pernonnbln. eoapcr.t1vu and bright. 3h.
a fine nuts. and V‘s chin to astunn responsibility fbr thn admin—
istraxion of drugs, the rating or patients. :nd the kneping at
rolenrch racordl fur a number at my studioa.
13

Whnn

I left

309 IOrk Mbdical College

Join no in Stony Brook and

I rogrcttod thut

I invited her to

she did not do no.

I trult this 1: hslptul.
ﬂinaoroly ycura,
Mu Fink,

M. D.

Professor of Psychiatry

MF/nr

2

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                    <text>tv—xw

,

vaq'"

.

,

,

r;_~.-

v

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..

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~

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WW
AOctober 16, 1975

M. Schneidor. Ph.D.
Senior Editor
Raven Press

Diane

Awenue of the America:
now York City 10036

llho

Dear Dr. Schneider,

I have never studied cocaine, and while I would be
follow
in the historic steps of Sigmund Freud, I cannot
to
delighted

do so.

My

present commitments are too

mneh

to beer as

it is.

I have not lbllqwed the latest cocaine literature, but
incidental.resding in the psychiatric Journals, I don't think
there's sufficient new infbrmntion to warrant even a systematic
review urticle on this very limited subject.
from my

nr

~i‘4'1/

Ira-7.,“th

to reed the volume put together by Dr. Eyck,
"cocaine Papers," published by Stonehill. Dr. Eyck is a well-trained
physician and he was unsble to put together a very useful volume.
A copy of my review of his book is enclosed.
You may wish

E'v'r-

Thank you

for thinking or

me.

Sincerely yours,

pr“;

.~

,

n«;.n

,
A

w

rrn

Fink, M. D.
Professor of Psychiatry

Mex

MA

32%

cm,

“m

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                    <text>0.77“

Catcher 22. 1975

David do ﬂied, M.D.
quortmsnt of Pharmacology

Uhivoroity of Utreoht

VandeLoen 6
Utrecht , Roll-ad
Door David,

weeks ogo wo had an interesting visit from
Dr. Urban, who presented some interoeting data from your laboratory
to a amall group of my coworkers; end we enjoyed his visit.
Some

I have reoeivod an inquiring following on the roport
of your work which appeared in the "Saturday Review." I enclose
tho inquiry and oak vhnther you or your associates can enlighten
me and Hr. Rnduna. I would be grateful for your advice.
When next you coma to the U. 8., I would be delighted
to visit the galleries again with you. Let me know when you are

coming and

again.

it

will give
My

me

an oxouso

to visit

now York City once

best regards,
Sincerely yours.
Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

Enc.

�</text>
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                  <elementText elementTextId="103933">
                    <text>"7.,” ,,

~--—

—

.v.-. ,,

...«_w-..e,~J-_ rum'vxuifﬁ

,

uvwamrwv“WNW

.mrﬂ...“ ”‘37..

v,

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1.7

any n»... in

...w

rrwwuvwmuw'«-~.——..

‘w.

»

‘. YT...

“

.‘..,‘_._r-,

Octobar 22, 1975

PM

L.

mm. “.8.

Central E1¢nnnt:ry'8chool

Fourth Awunun &amp; Bueand Struts an.
8%. Cloud, Hinnosot: 56301
Dear Mr. Badman.

unknown

I rugret to any tha£ the ansvnr to your quastion is
to no. I do not know if Ill. und (bugle children differ

in their lavnla or

I
in Holland.

ABTH.

ham. sent your

letter

on

to Prottssor

David doWiod

3. in the principgl invoctignmor of this

and perhaps ha

will

haw! an unswur

program

fbr you.
Sincerely yours,
Pink, M. D.
Profbasor of Psychiatry

Max

MF/ur

.10.“, ,.

,. .

.«rw

,

,4

..

.

.,

�</text>
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                  <elementText elementTextId="103932">
                    <text>.».Vt{m".\'

mm:

mnwrr-

:wwn run-r www- I'vw-K w-vr

v

-

v-vvv—rv-mv u-"v-

.r.

-

.

-~

"‘~a.»wm;.w 4%; r

.r-

W
October 23, 1975

_

William 0. Clark, Ph.D., Editor in Chief
Principles of Psychopharmacology
Chief, Psychopharnacology Research Laboratory
Veterans Adnﬁniatretion Hospital
Sepulveda, California 91333
Bear 3111;
The following information describes the training program
available in this department. The training opportunity is in the
Laboratory for EEG and Human Psychopharnacology, and in the Division of
Therapeutics of tho Long Island Research Inetitute. I an the director
of the program and member: of the staff are lieted below.
we have generally worked with Fellow: who Join the Division
for e onenyear period, or longer. The work is principally a research
opportunity in electrophysiology as applied to paychopharmacology and
candidates are encouraged to undertake individual research projects,

which are funded by
’r"

overseas.

my

or.

this Laboratory.

Stipends are available, particularly for candidates from
’

.,,

is

application of quantitative EEG
to pharmacokinetic studies. classification of the montally ill,
The emphasis

«mm

.7
.A

'ra'l-mpvvl

-r-

.

on the

methods
and identification or new,peychoective substances. The work is focueeed
on normal volunteer: at the University and in patient populations at the
Long Island Research Institute. Both laboratory and clinical work are

included.

wmwuwm-mwrv

_.
u":

For physicians, a requirement is an ECFMG, or a license to
practice in the State of New York, if they wieh to participate in the

clinical program.

.g-rwvw

Wm-

The only language requirement
members of the staff

the studies; however,
and Spanish.

is that English is used in
are facile in German, Italian,

�Willi“

Go

ﬁnk,

Ph.D.

10/23/75

“’2"

in...”

...,.

l-

.

H.

A.

U...”

..,.,-..

‘Jn‘n’-

do not give e degrse for this work, but candidetca who
hers completed two yeere of resiasney training cen obtain credit for one
year toward their Board requirements through this program.
we

3-,

The

present

numbers or

the teaching staff are:

”I“,
m
Professor of Psychiatry
MI Ds

Whiter

G.

Bennits.

M.

D.

Visiting Research Professor (University of
Alexander

Genoa)

M. Don

Asaociete Professor of Psychiatry
Bernardo Heller. M. D.
8r. Reaesreh Scientist
Long Island Research Institute
Michael A. armor; M. D.
Aeeociate Professor of Psychiatry
Richard Abrams,

M.

D.

Associate Professor of Psychiatry
Timothy

M,

24.1)...

Research Scientist
Long

no.
'

Island Retesrch Institute

I trust this intornstion is helpful.

volume!

Good

luck in your

Sincerely yours,
Fink, M. D.
Professor of Peychistry

Mex

MF/mr

think you might son a chapter on the electrophysiology of
in the revision? It was en omission in the first
drugs
paychosctive
edition which msde tho volune much loss useful {Or an in my teaching.
9.8.

—

Do

you

M.

�</text>
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October 31 , 1975

Itil,

Turem M.
HZI Research

150 White

Tarrytown,

M. D.

Plains
N. Y.

Road

10591

Dear Turan,
Would you kindln-eend a copy of your report on the
rating scale for TV records in psychophamcological research.
to the chairman of this department, Dr. Stanley F. Yolles. He
is particularly interested in using TV for monitoring sleep,
psychotherapy, and sex therapy. When I described your work to

him, he was unacquainted with

If you have
Many

an

it.

extra, send

me

a reprint also.

thanks.
Sincerely yours ,
Fink, M. D.
Professor of Psychiatry

Max
I:'

m-

.-

.r

v—p—wwn

«-

:c»

.q'

MF/mr

�</text>
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                    <text>~—:.--w~~ ‘TI,:~V:\-

mu.

7, Iv~-‘mtﬂ-V'KI"7

-

"~«W'r’em .u “w-I'VV-as-VF‘VZ—‘K'e .W‘wmwrum»

'nmm

Jun

‘—~&gt;v

u

mph-v“ we “w
w,

v

~..

_,_, rm...‘

Tun—r mun-he.

.,,

v

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.ﬂ.

‘4

November

Leon

Raisin,

1h, 1975

M.D.

Chairman, Organizing Committee

let International

Symposium on Neurotoxicology

N.Y.8. Psychiatric Institute
722 west 168th Street

new York, N.

I.

10032

Deer Dr. Roizin,

It is

indeed an honor to here your

ipate in the International

Symposium on

invitation to partic-

neurotoxicology.

effects of most paychoective substances
effects that these substances have on brain function, it
is difficult for me, on a scientist who has endeavored to identify the
CNS effects of these compounds because I believe the-effects to be ther—

depend on the

Since the beneficial

apeutic, to invert my findings and View them on "toxicology." Indeed,
to review these findings as neurotoxicologz would be very difficult.

I am reminded of the pharmacologic adage that one man's poison
another men's medicine.
effort

I thank

would be very

you

may be

for the invitation but regret thei such

difficult for

me.

an

Sincerely yours,
wan”

Fink, M.D.
Professor of Psychiatry

Mex
Agar-amen:

«w

MF/mr
wivm‘erWWWmﬂm‘mWﬂ’W'

wa'kn'w‘

WWW

&lt;

�</text>
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                  <elementText elementTextId="103929">
                    <text>”a

a

I

-

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- r- WWI"

&lt;

-

a

-~v

-

mus-aw,

.w

w

~-

-

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w an

r»

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.

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u

-

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.7».

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e,

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wry—m.

w.

If
November

«.e-u—W—WWWW...‘—mw-

1h, 1975

William G. Clark, Ph.D. Chief
Veterans Administration Hospital
Psychopharmacology Research Laboratory
Sepulveda, California 91318
Dear

Bill,

‘nwwwm-IVLAW

The
-

Lecture courses are given in psychopharmacology.to the medical students.
15 1-hour lectures which are given by muself and my

course consists of

co—workers.

Wu‘mmvmn

aaww-wmmmwv.»v—

w.-

W'Amwmmqnmﬁr'swm

WWW

w-

“VF-5

v

;

mﬁmvwr

'

.e—w-t-W

rt}-

"ix-ma

A similar lecture course is given to psychiatric'residents. In each of
three
their
years their exposure varies, so that first—year residents have weekly
seminars and lectures; second~year students have about ten hours; and third—year
students have lectures about special topics such as childhood payehopharmacology,

geriatrics psychopharmacology,

and drugs of abuse.

Psychiatric residents get an extensive experience in clinical psycho—
pharmscology since the leader of our residencyyttaining program is one of my
students who is convinced that hospitalized patients are benefitiddnnst+bvyblbe
logical ﬁlnﬁﬂment, and least by verbal.
Residents may elect to work for six months or longer ql‘an elective in
which
evaluate new drugs the efficacy and safety. ’Two~residents'are in
the units
such
now.
experience

It is

-

.

how to answer your question concerning lab work. The
monitor
their drug treatment by blood studies done at
residents are required to
least weekly,m at least monthly, anE EEG. neuropsychologiosl; and memory tests

not clear

at periodic intervals.

I

V

.

,

in

am glad that you hams a shapter on EEG and drugs
man.1t was a
Beside
omission
can
think of no
in your e-arlier session.
myself,
significant
be presumpand
write
such
woulﬂ
than
a chapter,
one better Qualifiea
Itil to
me
of
tuous
to attempt to modify his text.

V.

_

‘

wags-'1'!

I

it

Sincerelnyonrs,

nynjwwwvm-

Profesaprlof'Pnychiatry

m

mm:

V

r -~-

-~-

�</text>
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                    <text>,

-»

,-.

.m—wm-‘r

‘.

w;'

.u

—

.

"n ..- ‘&lt;py-1"'-"

Boveﬁber 1h, 1975

?

v.11.
«new,
Peychiexry
Pro eeeor of

En

'1:

in Residence
Xneﬁituxe
neuropeyoh1e$ric
Langley Porter

University of Celifbrnie
Sen

Deer

Frencilco, California

9h1h3

loch,

time we
from my

for your kind invitation. Ae the
met I had been under name pressure in not having heard
He
son in e number or weeks. I finally reached nine
so
Thank you very much

is planning to came home in: Thanksgiving
the pressure is off me at this time.
I hope to be able to cone Whit early next year end
ueuld be delighted to eccept your invitexion.
seems well end

My

coopereﬁivee

—

beet regard: and

my

notional thanks for being so
Sincerely years.
Me: Pink, M.D.

Professor of Psychiatry

MF/mr

�</text>
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