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                    <text>v..w“"‘

VIV'Wn-u-vwwm

May

Lyle Miller,

M.

Yximmiwumﬂwntmvﬁ‘w"all-'wv

:W

mm:

"'mw

D.

Eastern Pennsylvania Psychiatric Institute
Henry Avenue and Abbotteford Road
Philadelphia, Pennsylvania
Deer Lyle:

I put your letter of April 18 aside as I was trying
summarize the peptide literature for a meeting of the ECDEU.
am Inllosing a copy of that summary for your information.

up,

wﬁuﬂ?'—"‘

30, 197k

to
I

outline of a study of 'ACTH h~10 and Attention'
and as soon as you have the protocol in better shape,

The proposed

is interesting

I would have little difficulty in processing it.
to the dosage. Is not 10 mg low? Why not 30 mg?

One

question is

Regarding your comment on our 01—63 date, we have
studied the changes in alertness with placebo in our subjects,
and do find that it decreases in time. For some substances,
alertness is maintained, and this is defined as a drug effect.
In the 01-63 study, we did note the change in alertness, but were
not sure that the change was sufficient to be a drug effect. We
attempted to re~exemine at higher doses, and may have ignored a
finding. since a re~examinstion shows the same changes at higher
-doses. Thanks.

I look forward to reading the protocol of the suggested
Estudy, particularly the selection of the OPT task.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

Encl.

'

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                    <text>May

Riezen,

Honk van

Scientific

30, lQTh

D.

M.

Development Group

H.V Organon
Oso , Holland

Dear Bank:

First, let

me

apologize for not having reported earlier;

two weeka ago, I was concerned that my
impressions may have been in error, and knowing that she would be

but, after visiting Joyce
at the

her.

meetings. I waited to confirm.my observations with
Following are some notes concerning our projects.
ECDEU

chewed me

is directly involved with these studies.‘ Their optia
in studies of OI~63 was in marked contrast to their pessimism

Milstein

mism

with

1. Jozpe Small. I visited Indianapolis on may 7. Joyce
through the laboratories and we were accompanied by Victor

who

GB~9h.

They have completed nine subjects in
the series, and in no instance have they been able to avoid ECT.
While none of the patients exhibited a clinical.woraening, none im»
proved sufficiently to provide any feeling of optimism. When I enquired about side effects, she called her nurse—monitor who seemed
comforteble with the drug and unable to identify symptoms that were
problems to the patients. There were no "anticholincrgie" symptoms.
But Joyce's questions were sharp and her statements stronger than
the date seemed to warrant. I become concerned that we may be
seeing the development of e halo effect, i.e., the failure of the
first few patienta to improve markedly has set the etege for a
negative evaluation. She asked me whether she could discontinue
the study after ten subjects without 'breaking her worn’ to you.
(In discuseing this in Florida, she was more negative than the date
considering the very severe test to'which the drug was
warranted,
put .

a.

‘-

I'

wwwmm.w«nnnz

'v’.

s
‘2.

m

rang:

I]

r

03—

h:

�Hank van Riezen

May

—2—

30, 197h

I suggested she complete ten subjects, summarize
her observations, send the reports to you (me), and not induct
any new patients into this study until these data have been
digested.

b. OI~6§: This study is progressing well. Enclosed
sheet
data
summarizing her observations in nine subjects to the
is a
end of April. She finds 01-63 to have little effect in the immediate post-seizure recall period, but may improve recall at twenty—
four hours. She is anxious to go to the next groupof subjects, in
the same design, but at the higher dosage of 30 mg. I found this
suggestion reasonable, and encouraged her to proceed.
She and Dr. Milstein indicated that they were also
re-assessing the memory tests and they seemed pleased that some of
the methods they have developed had shown differences in OI~63
effects. Some additional tasks are being tested at the same time

as these studies are in progress.

Both she and Dr. Milstein were somewhat depressed,
however, about their local funding and space problems, reporting
that some of their grantgs had not been approved, and that she was

anxious to-obtain additional industry support for studies.

Joyce has collected tapes of EEG data with 01-63 and
is a unique 8—channel, l/h inch, General
Precision instrument which is no longer made. _Failing to find one
in New York, I decided to send a member of my staff (Peter Irwin)
GB-Qh.

Her tape recorder

with one of my h—channel recorders to Indianapolis to transcribe the
data from her tapes to mine; and we will then analyse the data here
(unless you prefer to use these tapes to test your system in 035?).
;I have set a date for June lB-lh for the transcription.

,,
w.

..

1-,_.-.,

am

.v:.

“View”:

‘qzvrr-rzn

)

-—-:

rm-zwsaﬁr'nn

Lyman-or

.1

14"‘A—W1n-mvimnjwy‘”

I

have had

(Joyce gave

a

little visitor's

and send them

to

packet of her programs;
for your.information.)

you

the presenwell received.
'(Please edit it
of the report is
and I would be grateful for any corrections of fact or-nuance that
you may suggest.) The diacussion was started by Joyce, who reported that she completed nine subjects in the ECT paradigm; that
there was improved recall of learned material twentybfour hours
2.

ECDEU:
The meeting was well attended,
ACTH Peptides on Memory and Brain
A copy
enclosed.

l,tation "Effects of
5

me

these copied

and

Function" was

�Hank van Riezen

«3~

May

30, l97h

after the seizure;

and that the effects were not evident in the
immediate post—seizure recall. She was encouraged by the find~
ings, and said she was extending the sample at a higher dose of
30 mg. Others enquired about the similarity of 01—63 to UCB

(prracetam) and to Unger's

compound

availability of the materials.

(scotophobin), and to the

timely because the next afternoon was
in depression and schizophrenia. The
N
data was sparse, with the usual of four to ten in each study.
Hoeehst was well represented (six visitors) and Dr. Alan Gordon
summarized the findings of European studies as equivocal or nega—
tive in depression. He reported sleep EEG studies, which failed
to show an effect of TRF. Drs. Prange, Lipton, Hollister and
Huey individually reported small studies without consistent findings in depressed and schizophrenic patients. Yet, each reporter
apologized for the paucity of the results; described some anecdotal,
single cases that were remarkable; and suggested that some findings
were there, although they did not know how to extract them. Itil
presented EEG and the clinical data from Turkey, and his report
was optimistic and constructive. He reported well defined EEG
changes, similar to dextroamphetamine, with clinical effects in
depressed patients of short duration, with self reports more
positive than observer ratings. There was some criticism of his
report, notably the question by Gordon that since he could not
find EEG effects of TRF in the sleep record, how did Itil explain
his findings in the alert subject. This gave Itil an opportunity
to describe the differences in methodology, the problems with
sleep assays, and the necessity for quantitative methods.
The

presentation

devoted to reports of

was

TRF (TRH)

I was left with the impression, both by the interest of
the reporters and the audience, that the peptides were now among
us, and that much study will have to be done in the next few years
defining their activity and developing new methods of analysis. A
few investigators (N. Kline. D.F. Klein, J. Simeon, L. Hollister,
R. Shader) asked about the report and 01—63, and I will send
copies of the report to them, hoping that their interest has been
aroused.
I am sending a copy of the report to the editor of
Psychopharmacology Bulletin for her consideration for inclusion
in a ferthcoming issue.

�~h—~

Henk van Riesen

May

30. 197k

3. FDA Report and Dr. Ksstin: I have decided to send
the report I have given to the ECDEU, as well as a covering letter describing the date of the Miller and the Fink studies.
I will omit reference to the recent Kastin end Sandman reports.
Abba sent me the latest report with a covering letter that seemed
unnecessarily harsh. However, I am willing to serve in the re—
lationship with him being acutely aware of his idiosyncratic and
irritating behavior, but accepting these as necessary accompani—
ments of the program.

the

FDA

In reading Ksstin's letter to you of April 29, I found
references to a study of ? OI—63 in schizophrenic patients. I
have not heard from Kastin regarding this study. Should he wish
to file an amendment again, and to avoid the criticism that we
‘are holding him up, I am writing to him directly (enclosed).

I

Because

h.

Essman:

I read the

Essman

letter

and the two

scales.

these confusing, I called hhn,snd he explained
found
He
derived from some studies by

that the tasks were

Squire.

'esserted that the tests have had some reliability testing (two
forms) and at least two applications. It should be interesting
and if they are sensitive to memory loss
(recent and remote), then thetpplication of the tests may be

to read these reports

useful
in the

5. Klein2 D. F.: we met in Florida (although we live
some community, I tend to see him in fer-away places) and

He wished to read the reports which
basis of my peptide summary, and I gave him a duplicate
set that I had with me. I shall send him a copy of the ECDEU
report and try to meet with him in Great Neck in the next two

began a discussion of OI~63.

were the

weeks.

I

have received a

letter

from Jack regarding

the visit

U. S. for a review of the date analyses of GB~9h, and I
have made arrangements for Drs. Boneto and Guy of the Biometric

to the

Laboratory in Washington

to assist us.

I have become even more interested in the peptides since
the
summary, and I look forward to listening at Utrecht in
writing
my

best regards.
Sincerely yours,
Man

MF:ed

'Enclosures

Fink,_M. D.

Professor of Psychiatry
,

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                    <text>p.

my

May

28, l97h

Gordon Barclay, Ph.D.
Director of Research

.

Department of Mental Hygiene
Albany, New York

,

Dear Dr. Barclay:
At a recent meeting of the
Jonathan 0. Cole brought the problems

investigators, Dr.
that are increasingly
facing researchers in various States of the nation to our attention.
He indicated that each Itate was frequently changing the laws and
suggested we contact the agencies in our itate to Obtain the latest
information regarding the laws now extant.
ECDEU

I have been carrying our research in human subjects in
various institutions of the State for many years, lately, at the
V. A. Hospital in Horthport, on the campus at Stony Brook, and soon
at the Central Islip State Hospital. I would appreciate references
to the laws applicable to studies in human subjects, including
patients who are mentally ill and normal volunteers. we study such
special problems as the eValuation of new treatments (including
drugs and convulsive therapy), and use controlled substances (can»
nabis and opiates)..

.—

-,.
.y

ma...“

»(

33w,“

Is there a codification of the laws applicable to these
research problems? Is it possible to obtain copies through your
office, or can you refer me to another that may make the documents
available?

.
,,._,

Many

thanks.

,.,m.......,.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

°

�</text>
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                    <text>May

28, 197h

Richard Shader, M. D.
Director of Peychopharmacology
Massachusetts Mental Health Center
9h Fenwood Road

Boston, Mass.
Dear Dick:

It was kind of you to spend time with us at Key
Biscayne. Both Peter and I enjoyed your discussion very much
and we left encouraged that blood level and EEG co—relations
were worth the effort.
it be
make

to collect some EEG, we
our facilities available to provide you with
will be glad to
analysis. Perhaps the meeting of the Society of Biological
Psychiatry in Boston next month may provide an opportunity for
us to discuss this further.
Should

Again,

my

possible for

you

thanks.
Sincerely yours,

r-v

aw»

”1.,

-num-»-~..-“awn”,

Fir-yr

K'w-wprv

~

-

mv-r

r-r

Fink, M. D.
Professor of Psychiatry

Mb:

mun—w.”

HF:ed

�</text>
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                    <text>W”—.I&lt;'

.-p~—

on

v

winwr/n‘rl

w"..-

May

28, 197k

Rhea Dorﬁbueh, Ph.D.
225

New

East 63rd Street
York, 3. Y. 10021

Dear Rhea:

I am enclosing a copy of the memoranda which I shared
with you and Castes. I think we ought to assume responsibility
for making up these various reports. Should you wish to work on
it with me, plan to come out here next week.
Peter has written the programs for the analysis of

Variance and

article

is testing

When

on

them today.

here,I forgot to give you the enclosed
are coming, and if you are
like to arrange a meeting with Dr. Krikorian.

you were

CHAT.

When

you know you

interested, I would
I have written a

summary of the data on the effects of
on memory. It has to be edited once again, but I will send you
a copy by the end of the veek.

ACTH

my

best regards.
Sincerely yours,
Fink, M. 9.,
Professor of Psychiatry

Max

MF:ed

Enclosures

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                    <text>May

Prof. Dr. T. Vbssenaer

Scientific Development
1‘;

. V.

Organon

Oss , Holland

28,

1971;

Group
.

Dear Jack,

I received your letter of May 17 as I was leaving for the
in Florida and was able to carry through on some of
while I was there.
suggestions
your
In going ower the GB-Qh data in Des, I became concerned with
two questions: the range of the differences in the date from each ine
differences in washout period, use of other drugs,
vestigator (i.
rate of dose increase); and the manner of handling the data reduction
(1 missing data, symptom scores vs. global scores, equivalence of
populations in the two samples). While the data may be in better 'shape'
than presented to me, and the processing may be quite satisfactory, but
I expressed my anxiety to Honk since so much (for Organon and for EEG
research) hangs on the analyses.

ECDEU’meetings

e.,

e.,

In answering your questions, I propose you allow two steps
in getting the answer: a preliminary review of a sample of the data
by the Biometric Laboratory in Washington, and a.more detailed review
soon thereafter by yourself and Mr. Stulemeijer with either a larger
sample or the total available data. The preliminary review will permit
Drs. Bonato and Guy to become acquainted.with the details of the study,.
and to relate the design and the problems to other studies that they
may

have analyzed.

If these steps are acceptable, I suggest that one set of
data sheets from one investigator be sent to no, as a sample of the
data. In addition, it would be helpful if we could have an estimate
of the total data available in a form similar to the outline attached.
I will send these to Drs. Bonato and Guy, and will plan to meet with
then to go over the prdblens and possibilities for analysis.
Based on these reviews, I will call or cable you defining their
suggestions and outlining the times available to them. I beliehe you

should review the data processing in their laboratory, not only fer its
statistical sophistication but for their experience in handling diverse

�2'

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page 2

date from diverse pepuletion annual“.

If these

suggestions are egreeeble, I am able to cooperate
any time up to July 20 when I plan to leave for Europe to attend the
meetings in Utrecht.

I thank you for your cements about. Dr. Dolce, end I agree
with your decision. I look forward to meeting Dr. Grosveld; hopefully
we can meet in late July in 033 or Utrecht.
I am enclosing a. com! 01’ e note to Heal: regarding the
ECDEU meetings, and w visit to Joyce Smell
swung her exper»
'

ienee with car-63 end caugh.

My but regards. I look forward
United Stetes in Jme or eerily July.

to

welcoming you in the

$1110.“er your: ,

Fink, M.D.
m
Professor of Psychietry

.1

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                    <text>May

\

21, lQTh

-v.mvr-r-

:rmzrv

Wrr.(_5‘r

v.4.

Robert Marc Hodges,
3720 Eampton Road

A

M.

Pasadena, California

D.

91107

1N&gt;Q&lt;V

I!"
J,‘

Dear Dr. Hodges:

wv-

"mu-

jaw—u.-.“

.—

---.

«m

.yw'wuum

mm

1.1

Vl—‘w

Enclosed is a reprint of one of our recent studies.
For a more detailed review of the problem, I would suggest you
get a copy of the volume, Psychobiology of Convulaive Therapy,
published by V. H. Winston and Sons earlier this year. That volume
was edited by myself, Katy, McGaugh and Williams. You may also wish
to find the 1972 issue of Saminars in Psychiatry, Vblume h, Ho. 1,
entitled, ConvulsiVe Therapy. Both will give you a better View of
the problem.

..-—,&lt;

Sincerely yours,

:.
‘

‘NW-nrvpxly.

Fink, M.D.
Professor of Psychiatry
Max

wv'lw‘

‘w'v'w

HF:ed

Enclosure

:m

van:

wwwzgnvlw'L

;,

&lt;;v.-w;z,,'

Wﬁ’

�</text>
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                    <text>William Cloves

Station

&amp;

Road

Sons Ltd.

Great Yarmouth

Hortblk, England
Gentlemen:

In this morning's mail, I returned the galley proofs of
the article, EEG Applications in Psychopharmacology, without checking
the figures. Later today, I received the proof of the figures and in
checking these, faund two additional corrections on pages 166 and 168.
On

page 166, the formula should have a

label,

GPA~111h.

first figure

does not have a label and
In addition, a line should connect the
"6303 with the Junction of the three points under the letter
first
"0" in th§ center of the figure (see xerox attached).
On page 168, the
should be marked, MK 2&amp;0.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

M3:

Merd
Enclosure

�</text>
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                    <text>May

16,

1971;

Leo Lange, M.D., M.R.C.P.

Central Middlesex Hospital
Park Royal
London

NW

England,

10

YRS

Dear Leo,

are prepared to work with Mrs. Rosselson early
regret. however, that you will not be visiting the
had
I
hoped to have the opportunity to go over our
for
States.
and
for
my
staff to meet you.
program,
in June. I

we

do

Please instruct Mrs. Rosselson to call me from
arrival. The various numbers are below.
I will suggest that she take a Long Island Limousine to the
community where I am at the time she calls-- either my home
in Great Neck, or the University at Stony Brook. We will make
the arrangements from there.
Kennedy Airport on her

My

best regards.
Sincerely yours,
Max

Tel:

Day: 516 hhh 2hh7 (University)
Eve: 516 751 h66h (if no answerQ)
516 166 Shhh

Fink,

M.D.

�</text>
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                    <text>May

16, 197h

Miss Mary Carol Revmann
SAODAP

Place, N.W.
washington, 9.0. 20506
726 Jackson

Dear Miss Newmann:
we

would be pleased

to cooPerate in the analysis of the

records to he collected in the SAODAP LdAM~methadone compari—
son study. As I understand the problem, the principal question is
to define the efficacy and the safety of s new pleparetion, levemethsdyl, in comparison with the standard treatment, methadone.
The EEG data is suggested as an index of safety, to define the
degree of changes in EEG as a measure of brain function during
EEG

treatment.

In our studies of methadone and levomethsdyl, we observed
systematic changes in the EEG with both compounds. The changes

related to the dose of each compound, the time after adminis~
tration, and to the time intthe induction (build-us; to the opioid.
Our studies with methadone defined persistent changes during the

'vere

h—6 weeks with episodes of EEG slowing and
which
burst activity
disappeared once a maintenance-dose was
stabilized and the patient received his dosage regularly. Dosage
regularity was important, for in a few instances we Observed theta
,‘burst activity in patients on maintenance therapy (100 mg methadone)
than drug intake was irregular or some additional substances were

build~up period of

used, usually opiates.

‘

it

For this reason,
could be important that the observatwo
tions be comparable in the
groups, particularly as to the
_regularity with which the dosages are given and the number of hours
siter a dose the EEG is recorded. As is usual with Quantitative
EEG analysis, the state of alertness of the sdee
must be con»
trolled; we do so by recording each sthect at the some time of

t

�Mhry Carol Hewmann

~2-

May

16, 197h

day, with the recording made with eyes closed for h minute 20
seconds out of every five minute sample - that is, the subjects
open their eyes and answer a simple inquiry every five minutes.
we believe a 20 minute sample to be an adequate estimate
of an EEG for our purposes. The sample should be in five minute
blocs with a to second eye opening in between. The details of the
recording for our analyses are described in the enclosed memorandum.

The

initial

data reduction

may be

either by period anal~

ysis or by power spectral density analysis. We have found both
useful for drug classification work. Unless your consultants request otherwise, I would recommend period analysis primary wave and
first derivative, using 20 second epochs, and 320 sps sampling rate.
We would analyse one load pair, preferably occipital~vertex first;
and only do a second if there are questions that are left unanswered
by the first analysis. We suggest that the recording on magnetic
tape be of the occipital-vertex, anterior temporal-occipital, and
frontalwoccipital electrode leads on one side. Should there be a
question of differences in symmetry, then a pair of symmetric leads
may be

recorded and analysed.

If the

records are presented cleanly on the tape, we can
l/h real time for period analysis or real time
for power spectral density analysis.

process the data at

fer each record by period analderive standard scores by contrasting the drug
periods with the pro-drug record. If a pro—drug record is not
available, then we can contrast the drug changes with the initial
record in each'subject, should you define the first records as
equivalent for subJects beiteen groups.
Having reduced the data

ysis (or

PWRS), we

these contrasts are
or louminute averages; and the changes
in the two groups assessed by an appropriate multivariate statist—
reduced

ical

The standard scores derived from

to either

5—minute

to contrast the changes induced by methadone and leveSince no placebo group is available, the final statements
are limited to descriptions of the changes associated with each
condition; the changes in time; the identification or individuals
who are outside 2 or 3 SD from the mean of the group; and a contrast
of the levomethadyl changes with those occuring after methadone.
Should the changes be consistent with previous experience, it may
be possible for either Professor Roubicek, Dr. Vblavka, or myself to
method

methadyl.

contrast the observations with the data recorded earlier at the
studies.

NYMC

�szmw n:

hhry'Csrol

Newmenn

The

w-vuwu- um..-

-‘

.. .n- 7.. w..,..,.... ..

‘n-nmwr

~3~

w

.7...“

__,.

-w. c,

V. . ..

"I'V-‘mum‘;§~w

'

facilities at the Health Sciences

May

p. —,,.‘.-

n.

we

in.

.....,

,

on. c .,

.....

..

16, 197k

Center

at Stony

these analyses for records provided on compet—
ible tapes. This laboratory is supported in large part by grants
from the National Institute of mental Health and the National
Institute of Drug Abuse. we can, therefore, to the extent these
other funds are available, provide the analyses at reduced cost

Brook can provide

SAODAP.
The 2&amp;0 hours of EEG estimated to be recorded by
Sharon/Burch and the 150 hours by Resnick/Volavke could be re—
duced in 100 hours of machine/operator time at $1¢ui§/951-

to

we

‘f

would estimate an additional 2 weeks of operator time
IBM 370—65 machine time for the statistical ena1~

“”“"EEETIh’hours of

yses provided in this study. Should the analyses requested by the
committee be more sophisticated then re can provide, we can provide
the committee with the data in card format on Hollerith cards or
IBM compatible tape for statistical analyses elsewhere.
.

Our budget should include travel funds for two trips to
Texas by a member of the staff; and two trips to New York. The
option of whether the trip is made from New York to Texas or the
reverse must be left in our hands.

also request an allowance of $4Zﬁ5. for telephone
pend other special charges that may facilitate this proJect.
The budget estimate does not include any fees for the
investigators in my laboratory. We are under contract HEM h2—73-260
and we would use the support of that program for the remainder of
19Th to cover any time charges for the investigators in this labor—
atory. particularly myself~and Mr. Peter Irwin. Should theweproject
re~
‘proceed beyond the December 31. l97h end of that contract,
for
201/month
the
of
operation
of
1975
funds
the
at
rate
in
quest
Mr.
the
study.
Irvin
manage
to
of
the services
Budget estimates are attached, reflecting these suggestions.
Should you wish to approve such a contract. the additional funds may
be added to contract DA hPGOOS, Arthur Zeke, M.D., principal investigator, through the International Association for Psychiatric Research.
That agency is also the grantee for PHS funds fer the program "EEG
and Human Psychopharmscology", ME 2&amp;020, which provides support for
the computational equipment which is needed for the analyses de—
scribed in this memorandum.
we

V

�Mery Carol Newmann

Hey 16, l97h

-h—

I trust these

comments are helpful. We would be pre~
Irwin or another member of my staff to Texas to
staff there in the proper recording of the data for
analysis. It may be helpful for Dr. Stillman or you to visit our
laboratories to discuss the work further. we are prepared to meet
with Dr. Stillman and the investigators to design the actual recording times and sessions to maximize the data for the questions
which are to be answered by these analyses.

pared to send
work with the

tapes;

I

Mr.

am

enclosing a set of notes for recording and identifying

and a budget estimate.
Thank you

for your inquiry.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

Merd

Enclosure

�qua-m.—

wg,‘:va.y""

may 16, l97h

msry Carol Newmsnn,
Max

Fink,

M.

SAODAP

D.

Budget Estimates

for

LAAM—Msthsdono EEG

Analyses

is provided for the analysis of she
single lead pair to be collected by Shsrms/Burch;
and 150 hours EEG, single lead to be collected by Bosnick/
Vblaxka. Analysis by period analysis, l/h real time.“
hours

EEG,

This estimate

Primary Reduction
390 hours

I l/h

x $1h.50/hr

$

1,h00.00

Artefact control

(100 hr x $5/hr)

500.00

Data compression

200.00

Statistical Processing

1—]:

.d'n'r—

"r

Operator time
(2 wk 0 $250/sk)
Computer time

(370/65 s $2oo/hr x

Summary Reports

500.00

hr)

h

800.00

(1 wk)

Travsl

250.00
.

1,000.00

Incidental Costs (tsl.,postags)

250.00

2

arr-r1?!”

After 1/1/75. Personnel costs
20%

x $1,h00/msn

. $280/msh a

8,220.00
IAPR

Overboad Zhﬂ

7.:

a

v'ﬁmnhr

Var-159149:

20.00

“Should power spectral density analysis be
requested, change estimate to a real time
analysis by multiplying primary reduction
cost by h.

.00
$10,193.00
1

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                    <text>7hSB-l22SB
May

J. Silvio, M. D.
National Institute of
Rockwell Building

10, 197h

Drug Abuse

llho Rockville Pike
Rockville, Maryland 20852
Silvio:

Dear Dr.

Enclosed is a formal report of the studies completed at
Hospital, Northport, under contract HEM h2-73-260 during the
first quarter of the year.

VA

While we have obtained the support of the local staff at the
Hospital and have a fine facility, VACO has decided to end the
DDTC funding on December 31, 197h. They have indicated they will
provide a decrease in the budget fer the second half of l97h and none
fer 1975. This support is the mainstay of our program and we cannot
sustain our effbrts without it.

VA

With the funds remaining in the contract, we can sustain the
project through the third quarter of the year, provide followuup for
some patients during the fourth quarter with an orderly termination
of personnel and transfer of patients to other treatments with the
present termination date of the contract.

Unless the present circumstances change, we will be unable
to participate in this interesting and imyortant study program beyond
the present contract period.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

max
MF:ed

Enclosure
cc:

3. Yolles, M.D., H30
8. Kieffer, M.D., KSC

D.A. Swanson, M.D., VAR
Brissendin, M.D., VAH

A.
M.

Knahner, M.D.,Dean,

HSC

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                    <text>May

10,

197%

J. Poppl, M. D.
Institut fﬁr Datanverarbeitung

S.

der Gesellschaft fur Strahlen—

and Umweltfbrschung

Arabellastrasse h/l
8‘MUHCHEH 81
WEST GERMAHY

Dear Dr. Poppl:
As I indicated at the Kronberg meetings, I very much enjoyed
and your presentation. I have had an opportunity to
discussions
our
review your suggestions with my co-vorker, Professor Donald Shapiro.
I would like to havbean opportunity to go over our data processing
methods and discuss classification possibilities with you during your
next visit to the U. S. we are prepared to make available sets of
our data for trials in Europe; or to use the computer facilities
here for such tests as you may feel useful.

for transatlantic travel, we can
surely defray all your-expenses during the visit to our facility.
I would be grateful if you would let me know when next you plan to
While wo do not have funds

visit.

My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

�</text>
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                    <text>ThSB—127SB
May

10, 197k

Burtcn J. Goldstein, M. D.
Dapartment of Psychiatry
School of medicine
P. 0. Box 875
Biscayne Annex

Miami,

Florida

33152

Dear Burt:

I was pleased to have an opportunity to chat with you in
thhington at the Anxiolytic meetings. I am taking the liberty of
enclosing a memorandum describing a fellowship which has Just been
established in this Department. You indicated that you had appli~
canta seeking Jobs.

criteria stated in this description,
grateful if you could bring them to my attention. I look
fbrward to visiting with you in Miami later this month.
I

Should any meet the

would be

Sincerely yours,

an: Fink,
MF:ed

Enclosure

"an:

.mnﬂn'r

M

”yawn-mt”

a;

aasemr....

Maw

M. D.

Profbssor of Psychiatry

�</text>
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                    <text>May

Richard Phillipson,

M.

10, 197h

D.

National Institute of Drug Abuse
Rockwell Building
llho Rockville Pike
Rockville, Maryland 20852
Dear Dick:

I could not help overbearing your recommendation of a
candidate for residency to Jon Cole during the Anxiolytic meeting.
K

As I am writing to some friends describing a fellowship in
this Department which has Just been created, it occurred to me that
you might have other friends from England vho write to you looking
for opportunities in the States. I am taking the liberty of send~
ins you a copy of a memorandum which deacribes the opportunity.
Should you have a candidate whom you may care to recommend, I will

be grateful for your recommendation.
My

best regards.
Sincerely yours,
Me: Pink,

MF:ed

Enclosure

M.

D.

Professor of Psychiatry

�</text>
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7588-12683
May

10. 197k

Mr. Vincent Keely

23 Samoset

Street

Dorchester, Maine 0212h
E

i

;

;

Dear Mr. Keely

I regret that no-mechanism exists fur weekly payment for the
volume of Convulsive Therapy. may I suggest that you set aside the
sum you would have sent in a Jar in your bedroom, and when the
requisite amount is available, purchasing a money order at the Post
Office. This will provide a less expensive and more direct way of
solving your problem.
Good

luck.
Very

i

Fink, M. D.
Professor of Psychiatry
Max

MF:ed

truly yours,

�</text>
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3W
SBYH'12SSB
May

Bruce Richman,

10, l97h

M. D.

Department of Psychiatry

Duke

University of Psychiatry

Durham, North Carolina

27710

Dear Bruce:

pleased that Dr.

I cannot

you
tell
Faun

how

Our move

to Stony

Brook has been

delighted I

am

that

you have been so

has invited you to go to Houston. I do not
know the kind of work that will come from Houston, but for many years,
I have known of studies undertaken by Dr. Heil Burch and the Houston
State Psychiatric Institute. His work is outstanding in quantita~
tive EEG and you may wish to visit him once you are in that City.

audiessful.

The

laboratory

is running well and Peter, Ira and Maureen are the mainstays of the
lab. We are very interested in the relation of EEG to blood level
of drugs and hope to make acme contribution through this effort. The
studies run well and our principal difficulty now lies in the statistics rather than the data collection.
Should you find yourself in the east, come and visit; and
should you find the heat and the reactionary thinking of Telas too
much for you, come back to work in the heady free climate of the
eastern seaboard. Whenever someone tells me he is going to the miduest or the south, images of my feur years in St. Louis thrust them—
selves into my consciousness, and I am reminded again and again of
the stubborn, reactionary and preJudiced attitudes of the community,
in which I worked. This attitude was not limited to the locals, but

included the professionals at the University as well.
Again,

let

me

congratulate you on your progress and wish you

success in getting your doctorate soon.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

�</text>
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                    <text>pvnwwvawwrwv.

7....p

H......,...,.Vw.,,.wm....u-M. .7”... u.

w—«\'~‘

w.

nip—vw—rr-

~

7

q.

.

7w

. m,- -—--vm-,.y '~-

nun-ru-

-v'-

'«-~

~.

'—

.Y

7hSB~1238b
May

10, 197h

Mrs. Mildred K. Lehman

Chief, Mental Health
Rational Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
_

Dear Mrs. Lehman:

I very mtch enjoyed the conference

on April 17, 197h, and

I am indeed grateful fbr the tape. I have already received a number
of calls and letters tram "patients" who read an overuenthusiastic
summary which appeared in a Chicago newspaper.

I hope the meeting served a useful purpose fbr
glad to have had the opportunity to participate.

NIMH

and was

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
M3:
MF:ed

,

n-

-

FW "

7"

"'

�</text>
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                  <elementText elementTextId="103870">
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May

Robert L.

Spitser,

3.

197*:

M. D.

Director, Evaluation Section
Biometrics Research
State of Rev York

Department of Mental Hygiene
722 West 168th Street
New

York, New York 10032

Dear Bob and Jean:

Criteria
I have read the sﬂhmission of ”Research Diagnostic
A

'

formidable produc—
for e Selected Group of Functional Conditions".
tion! Congratulations!
While the details are necessary, I find the descriptions
complex and "phenotypic". By that I mean that the clues which have
come from genetics, and the lesser clues from neurophysiology, and
the response to treatment. are not included in the classification.
Considering the state of the art, this may be necessary, but I
would be more enthusiastic in applying this classification if there
were ways to include the suggestions in the evaluation.

principal omission is the response to prior treatment
and the response to a therapeutic trial in the present classifica—
or hypo—
tion. The response to lithium by those with manic illness
from
the
nsnic episodes may he used to separate these two groups
schizophrenics. Some scientists claim that the response to ami~
triptyline is of diagnostic value in bipolar depression. In the
The

that Don Klein and I did more than fifteen years ago,whoververe
reconvinced that there were sub-groups of the mentally
sponded differently to phenothiasines and impramine. These comments
should be enough to suggest that the response to therapy may have

work

some

ill

place in the classification scheme.

o,‘

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,

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.

757.7”

With regard to your specific question, I never use
"ihnic Illness" and "Hypomsnic Episodes", for I was taught that
"mania" is "mania". I also find the syndrome "Schizo-affective

type", difficult to differentiate from manic ill~
ness. I
if the difference between "minor dysphoric illness"
_end "dysphoric personality" is not 3 case of nitpicking.
disorder.

manic
wonder

With regard

to Items

1h and 15, I think alcoholism
e sub—type of drug dependence.

is not

I find
s separate disorder, but is
"drug
"drug
dependence. opiate type",
useful the classification
dependence, alcoholic type", and "drug dependence, mixed type".
has suggested that "homosexuality" not a diagnosis of mental disorder, I would accept this View.
As

the

APA

These comments are not to be interpreted as criticisms,
fbr I think you and your teammates have done a splendid Job. I
would be pleased to see the versbon after the next review.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

w”-

‘

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.,.

.

_

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Hank van Riezen, M.D.
H.V. Organon
Oss , Holland

Dear Henk,

I have received the extensive documentation for the

report and I thank you. I will get
you a copy before the meetings.

to

it

01—63

next week, and will send

I regret that I felt I had to disturb you at home last
it seemed prudent to report Joyce's concern. I am scheduled
to visit her on Tuesday, bay 7, and I will report fully thereafter.

week, but

The report to the ECDEU will be sufficient for the FDA. I
realize Kastin’s concerns and I have no need or desire to increase
his anxiety. I have sufficient data now.

in your letter of April 17 sent me to a
associates. The best laboratory to assist us in the
analysis of the behavioral data of the 63-91; study is probably
the Biometric Laboratory of George Washington University. This
center was established with government funds and is supported by
a large contract to develop methods for rating behavior and to assist
investigators. The directors are friends, Ronald Bonato, Ph.D. and
William Gw, Ph.D. Before recommending them, I screened two other
units: the VA laboratory at Ferry Point under Dr. James Klett and
the laboratory of John Overall in Texas. I believe the best unit
for our purposes is that of George Washington University. I met with
Bonato and Guy at a meeting in Wshington yesterday and they agreed
to review the data and to offer their advice and support. I also
met with James Klett, who will be able to meet with us, but is
unable to help with the data. Should you wish to send Dr. Stuhlemeyer
to the U.S. , I would be glad to arrange to visit Washington with him.
number

One comment

of

11V

to

it

to come
to Florida, to attend the
the discussions. He could spend some time in Washington thereafter.
He should bring copies of as much of the data as is representative,
with as many of the analyses that have already been done.
Should he wish

come,

ECDEU

would be

helpful for

him

sessions and to hear the level of

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.....................pg. 2

As for the costs, there is some problem. Officially,
the Biometric Laboratory is not organized to process data fer
industry, but for investigators. They will analyze the data if

it is listed as coming
if you obtain releases

from an investigator (such as nyself); or
from each of the participants. They cannot
charge a fee. Should they assist you (us) in a meaningful way,
id possible for me to reimburse them for their time. I would suggest
that you allow an initial budget of $1,500, with the guidelinethat

it

pay a consulting fee at the rate of $lSO/day. Should their
contribution warrant, I can clear the payments through you in advance.
(Should their contribution be considerably greater, I can suggest
the amount be increased.)

we

As

for the other notes: I will write the GB 9h protocol
will include the collections suggested by Dr. veen.

next week and

series of studies in the neighborhood
schools, in which the teachers refer children with behavior problems
and reading disability. He and his wife have a team examine the
children, evaluate the clinical condition, and then assign the
children to systematic studies according to the diagnosis and
according to their protocols. These involve administration of
placebo, drug, or comparison drug for extended periods; with
psychological test, clinical behavior evaluations, teacher and
parent ratings, etc. at frequent interviews. The program has
developed data on dyslexia, eneuresis, phobia, hyperkinetic
states. Their clinical and psychological data are excellent; their
Donald Klein has a

physiological measures need improvement.

is still in
Israel; has received my letter; but indicates that he will not be
back in London befbre July. He is planning studies to begin next
March/April, and.vill surely write to you this summer.
I

send

met Dr. Marks in Washington yesterday. He

Please excuse the typographic errors, but I decided to
be back in my office until

this off myself because I will not

next Thursday.
My

best regards.

Sincerely yours,
Max

Fink ,

M.

n.

WﬁFuru'xw-I—WW'IEI‘IR—

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                <elementTextContainer>
                  <elementText elementTextId="106898">
                    <text>.W
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.

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r

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May

2:;

1971*

Dear Milt ,

E

.

I

relationship with the
acquainted with their programs. The
director for research, Donald Klein, is a well—known clinical
psychopharmacologist with an interest in psychopathology and
clinical trials. He is not particularly focussed in basic
science approaches, leaving the medical aspects to an
internist, Arnold Blﬁmberg, and the neurophysiology to a
classical, descriptive electroencephalographer, Struve. I
would not be sanguine that he has an opening, but you may
wish to call him and inquire. You may cite me as a reference.
While

,
a

ww1-y,‘m.w—wr—ymnu-wv—n-w

.m—wmw—“I—I—r“
r‘mm—‘w-m

‘n'i-‘w—

“A.“

no longer have a formal

staff at Hillside, I

Europe.

I

am

am much more

Good

impressed with the opportunities in

luck.
Sincerely yours,
Max

Fink ,

M. D.

1r.

-

v......-v y-—ra:¢m'ﬁw-'_

�</text>
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Prof. Dr. Antoine
LEHA

L8

1,

lQTh

Remand

Salpetriere

hT, boulevard de 1 Hospital

F—7563h,

Paris

Cedex lS/France

Deer Tony:

I very much enjoyed the discussions at the GEAR. You seem
surprised that we, in America, were already making direct applications
of computer methods for clinical purposes.
In my report, I lescribed two applications to clinical psycho~
pharmacology which are ongoing in my laboratories. At the same time
as I was working on this program, Prof. E. Roy John and my co-worker,
Dr. J. Valeria, were developing a computer—based Neurophysiology Clinic.
A description of their application
is enclosed as you requested. When
I inquired last week, I was told that they have a waiting list of more
than two hundred who seek this service.
EW'best regards.

Sincerely yours,

MF:ed

Enclosure

Max Fink, M. D.
Professor of Psychiatry

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                    <text>April 29, 197k
Mr. Herman Weissman
Hoffman— La Roche Inc.

Nutley,

New

Jersey

07110

Dear Hank,

Enclosed is an original, unbound copy of the report
summarizing our experiences in assessing the EEG profile of
bromazepam and its comparison with diazepam and placebo; and
the blood level correlations. I am also enclosing three bound

copies for Phil

Bookman and

other associates.

Please be advised that the original data of the EEG
assessments, behavioral observations, and subjective data are
in our files and may be made available at your request.
I want to take this opportunity to thank you and your
associates for your cooperation and patience during this study.
I believe we have made some progress in characterizing the pharmv
ecology of these compounds, and in the process, we have learned
a great deal about our methodology.
My

personal regards.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

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lQTh

AG

Herstellung 2
CH h011 Basel
Switzerland
Gentlemen:

I have reviewed the page proofs of the article,
Profiles and Bioesailability Measures of Psychonctive Drugs,
to appear in Itil's volume, Psychotropic Drugs and the Human EEG.
Except fer the correction for the degree of Peter Irwin, I

EEG

{bond no typographic

errors..

4"(‘ew1'vnn‘l'w

"-1

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\Pages

81—8h

have been

should be part If
not appear as part of the
reset of these pages, and
the lines suggested, with
1 and 2

page 83.

laid out poorly. Figures

the section, Fentluramine, and should
doxepin section. I haxe attempted a
suggest that you reset the pages along
figure 1 on page 82 and figure 2 on

Thank you.

Sincerely yours,
Mex

cc; T.

Itil

Fink,

M.D.

Wm,

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ThSB-lthB
April 19,

lQTh

Larry R. Squire, Ph.D.

Assistant Professor of Psychiatry
veterans Administration Hospital
3350 La

Jolla Village Drive

San Diego,

California

92161

Dear Dr. Squire:

are probably correct, that {cllov-up studies of
relatively insensitive memory tests. In our
work at Hillside Hospital, l95h—1962, and at New York Medical
College, 1967-1972, we have not looked at long term effects
systematically. In one study, our fellow—up was lO—lh days
after the last treatment; another, the last week of hospitali—
zation which varied from 2 weeks to a few months.
You

ECT

and

have employed

Teuber

is

I did study the

to your usestions.
The

EEG

condensing some recollections.
EDT

Pollock
would
data
not relate
but
our
process,

date was published by

M.

A. Green

in the

Journal of Hillside Hospital, 6: 229, 1957, and Journal of
Nervous and Mental Disease, M3: 117, 1960.

You may be interested in checking the summaries of our
work published by my co—workcrs and myself in "Seminars in
Psychiatry", volume h, No. 1, February 1972; and in a new
volume entitled "Psychobiology or Convulsive Therapy", pub—
lished this month by Winston and Sons. I am enclosing an ad—
vertising sheet for your interest. Should you find references
in either volume that are of particular importance to you,
please do not hesitate to write.

I
know that you are cognizant of the special problems related to)
differences in memory function measurements based on whether
they are visual or auditory, and their sensitivity to practice
I think your study is s very important one,

and education.

and

.

�I would be pleased to have the opportunity to read
the reports as they are submitted for publication.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

Enclosure

'

’

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                    <text>W
7h8B~105SB

April 12, 197h
Albert

A. Kurland, M. D.

Maryland Psychiatric Research Center
Box 3235

Baltimore, Maryland 21228
Dear Al:

I share your concern regarding the reduction in psychi-

atric research support, particularly the negative impact which results from concerns regarding the "rights" of patients. I am sure

you know of

the severe reductions in programs at the Missouri

Institute of Psychiatry. The two senior scientists, Turin Itil
and George Ulett have left and their work has been severely curtailed.

At this Institution, we have been unusually fortunate,
for our programs are new and the excitement, enthusiasm and expertise of a new faculty serves to expand our research programs
with minimum impediment. we have been called upon to participate
more actively in faculty committees, particularly those related to
research and teaching, than any of us had been called upon in prior
years. we consider participation in the committee systems critical
to our salvation.
So as to complete the national picture, the reduction in
support for psychiatric research apparently includes reduction in
industrial support. I have received any inquiry from Milton
Kletzkin of Wallace Laboratories seeking advice as to a new position,
as the research programs have been severely curtailed.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

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                    <text>12

April

197%

ARIK BRISSEHDEN, M. D.

V. A.

MAX

Hospital

'

PINK, M. D.

Treatment of Chronic Schizophrenia with Oral Hypoglycemic Agents

his

I have read the protocol submitted by

co—workers, and would approve the mission.

Dr. Messinger and

There

is a theo«

reticel objection to this study, since ineulin come therapy has
been found to be thoroughly ineffective in the treatment of
schizophrenia. Hypoglycemia may not alter cerebral activity until
levels lower than

achieved fOr extended periods.
For both these reasons, I would assume that the treatment yroposed
is essentially a placebo thereepy with smell additional risk.
30 mg% have been

However, the risks are small, even acknowledging the
caraiovasculer risk assessed by Dr. Fritts. If we acknowledge
that the therapeutic effect of enthusiasm of the observer and
systematic observations may be mobilized for the treatment of some
patients; I do recommend approval of this project because I believe that Dr. Messinger will be stimulated by his enthusiasm and
we can anticipate some discharges from the hoepitel using this
regimen. I would be less sanguine about their finding meaningful

scientific data.

MF:ed

-

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                    <text>WM

April 11, 197k
Dr. Milton Kletzkin
h? Gage Road

East Brunswick,

N.

J.

Thee—10183

08816

Dear Milt:

I have Just returned from e moat stimulating trip to
Europe. While in Holland, I met with friends at N. V. Orgenon,
a pharmaceutical concern now actively involved in psychophermeeology. They are interested in exyending their programs. Should
you be interested in working in Europe, I would suggest that you
send a copy of your Curriculum Vitae to Honk van Rieeen, M. D.
his co~workere are among the finest
I have been associated. They have unusual
compounds and investigate them for human trial by the most edveneed methods. It would be fair to say that I know of no other
concern which would provide as fine an opportunity to work
Dr. van Riezen end

scientists with

whom

imaginatively.

Following my visit to Holland, I attended a meeting on
computerised EEG and met Leo Goldetein there. At breakfast, «he
shared with me your wish to leave your present laboratory.
My

best regards.
Sincerely yours,
'Mex Fink,

MF:ed

cc:

Hank van Rieuen
N. V. Orsenon
OSS

Holland

M.

D.

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                    <text>ThSB—IOBSB

April 11, 197h
Mrs. Gail

M.

V. H. Winston

Parker
&amp;

Sons, Inc.

Street, N. W.
washington, D. C. 20005
1511

K

Dear Mrs. Parker:

I would appreciate your getting the following informa~
tion to the responsible officer at V. H. Winston:
I have been asked, by Science, to review a volume of
Convulsive Therapy published by Walter Eeemen. Indoing so, I indi—
cated that

more

of the issuee raised by Dr. Eesmen were discussed
extensively in "Psychobiology or Convuleive Therapy".
some

Miss Sylvie Eberhert is the responsible person in the
book review department of Science. If a review copy of our
tolume has not been sent to Science, 1 would appreciate that
one be sent to her at AAAS, 1515 Massachusetts Avenue, N.W.,
Washington, D. C. 20005.

Sincerely yours,

Merd

Fink, M. D.
Professor of Psychiatry

Max

�</text>
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TAMARATH K. YOLLES, M. D.
MAX

FINE,

M. D.

Alpha~0mega~Alpha

As e member of the New York University Chapter of
Alpha-Omega-Alpha, and a member of the faculty of S. U. N. Y.

at Stony Brook, I am pleased to support the application for
a charter of ADA for the School of Medicine of the Health
Science Center of

this University.

Fink, M. D.
Professor of Psychiatry
MEX

MF:ed

�</text>
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March 29, 19Th

Bettie MbLeod
Clinical Psychiatry

M8.

Hews

h907 Cordell Avenue
Whahington, D. C. 2001b
Dear Ms. MbLeod:

Enclosed is the galley proof with some corrections. I
have added a paragrayh which may put this presentation in a broader
context. One paragraph is marked as ”out of context" and probably
should be deleted.
A

Be

photograph

is included far your use.

sure to send

me

a copy of the newsletter.

Sincerely yours.
Fink, M. D.
Protesaor of Psychiatry

Max

Merd

Enc.

�</text>
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                    <text>March 28 , 1971;

Jonathan 0. Cole, M.D.
Boston State Hospital
Boston, Massachusetts
Dear Jon,

Enclosed are some of the forms that we are now using
to maintain alertness in our subjects and to assess changes in
behavior during our phasewI EEG classification trials. Our
principal method of assessing behavioral change is to ask the
subjects to open their eyes every h minute and 20 seconds (and‘
to keep eyes open for ho seconds), asking: "Do you feel any
change ?" Alternate inquiries add,
"On

a scale of

—6

to +6, would you rate any change in

your state of alertness (awareness)?" The subjects are told at
the onset of the experiment that their present state is to be
rated as '0’.

The symptom questionnaire is used befbre, at the mid~point
of the experiment, and after the experiment is over. Examiner asks
and notes responses.

a self rating completed by the subject before the
experiment, at the mid—point, and at the end. Rating is either by
hand or by computer program.
CMS:

Irwin inquiry: an open—ended sheet to maintain a running log
of the subject‘s behavior, answers to questions, movements, etc. In
the left columns, time is noted; 'as' is the alertness score given
by the subject;'bz' is the number of times a hand—held buzzer was
released during the previous time period; and '123’ reflects another
scoring estimate used by us in examining the effects of benzodiaz—
epines, and not relevant for your work. Page 2 of the inquiry is
completed at the end of the experiment.
From

this range of behavioral inquiries,

we

believe

we

have teased out some aspects of the subtle behavioral changes in
our subjects when we have used threshold doses of novel and established
compounds.

I

trust these

comments

are helpftl.

Good

luck

!

Sincerely yours,
Max

Fink, Mb.

�</text>
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                    <text>74%09583

W
of
Wat
adversity of
St.

27 , 1974

Dr. D. P. Bobon

Psychiatry

Sumo).
Meal
34000
58,

11396

Rue
Laurent.
Liege, Mame

mar Dr. 30mm

I read your article

on the

"Classificatims and Tarmimlogy of

lenﬂthrie,

of
in the
of haterest. I think your paper highlights the paverty
with a. great
for so many
of the miptive msologms. That it has hem
mnfor
so many
authors to develop so many descriptive term,
an
appmadm.
I
fleets the lack of merit of a molly plumnlogical
with
that you, who have had
writing bawuse I was
Us
seems
0f
than. It
m
electmpsycmlogical memes, nude so little
by changing brain fmction.
that psydnactive 611198 :30 affect
Brain fmmtimmasxmeaarepoor, withtlwbestbaingms. Aspooras
EEG
they still provide the best classificatim of
are,
Psydmotropic

{Danagazu

(Real

W33m,

January 1973 5.38%

W

61me
mm
Mr,
W
Wﬁwmmamewmmmﬁimtmamt
the
failures. Immzindedofthesaymg, ”Intkmlandoftheblind,

one—Wmismng, - forthisisthemyi mmcmamications.

Wt-

Ilamﬂmtyouarexmdoingmssmﬂiasmﬂlmﬂﬂmthat
for classification, after

you would come

to use mesa magma

mgsomllthattmdemiptivatmmomoftheﬂmtmtyyeamis

socmfusing.
My best regards.

Sincerely yours,
Fink, M. D.
Profaasor of Psychiatry

Mm:

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March 26, 1974

Craig

D.

Darrell,

M.D.

Chairman, Sectim of Biological
and radical Sciences
'1?» New York Madam! of
2 East 63rd Street
New York. N. Y. 10021

Sam

1388101319:

Itmnkyouforyourinvitatimmﬂwmwmrkmademyof

Scimmtingmhprﬂ
atripwmnope.

3.

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IWGeorqucm'sviewsarﬂItlﬂnktkmtyouamdoima

mummmvmgummw.

Impetheminggoesmll.
Simmlyyours:
Max

Fink,

M. D.

Professor of Psydxiatry

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7458-094

mrch 26,

1974

RED

P. 0. m: 28083
Caxtral Station

mm,

D. C. 20005

Gentlamn:
stances

ImﬂdlikaU.S.officia10rderfmforSdnduleIISub~

mmmimeim No. PF 0101701.

-

Amofﬂmtmgistmtimiamlosedﬁormgndame.
Bimelyyom,
D.
Fink,
mProfessor
of Paydﬂatzy
M.

Wmd
Em.

�</text>
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                    <text>W

m-u—y

ﬂ... r-my—vv» -.

.

W—w,wm—Iy“v-’-ywlrwhnww-n”am-,rwhpwm_.wsp,

"P, ~)'\yf;u—&gt;n-l-

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urn»

77

.~ "-“-.v~vwr‘-""I

".7:

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~-

_

(r'r‘w-‘swnww—an'q-‘vurm -~.—-\ new“

March 22, l97h
Henk van Riezen, M.D.
N.V. Organon

Oss, Holland
Dear Henk,
am

I look fbrward to visiting with you April 2-h,
writing to bring you up-to~date on a few matters.

and

I

1. Before submitting the supplementary information on
the 01-63 placebo to the FDA, I called the FDA as it has been more
than 2 months since we submitted the original data. They have not
made any determination, so I sent the additional data. I will
have to call them again if we wish a response.

I called Joyce Small about a report. She has sent you
week. She is now finding effects that may be
drug—related and she is testing additional subjects at the 15 mg
dose. I received and sent to her, the additional supplies of OI~63

one

2.

earlier in the

she requested.

'V‘V‘I'E'

In talking to her, I raised the question of EEG effects
of chronic administration of GB-QL, suggesting that we would analyze
her reqords for comparison with our studies of the acute effects. She
was not enthusiastic, pointing out that her tape system was incompatible with mine. Rather than proceed against her initial Objections,
I deferred the discussion until we have had an opportunity to explore
the need and the alternatives.

“.1

a...”

w—n—rv-

«mwrvf'm'ié'wwﬂmiﬁmw'

mar!"

w

w-mwmw-ummw-w

m

A

A

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”-4,

studies of

3. The

01—63.

Abba and Lyle.

has asked for a progress report of our
I asked Joyce for her data; and I have written to

FDA

h. Your review of the Miller report was so thorough that I
could not add much. I was also disappointed in the report and I have
sent it back with some marginal notes supporting your comments.
5. Hastin has sent a new protocol for a study with Sandman
and George. I find it incomplete for filing and I have returned
with a request for the additional information. I will bring a copy

it

with

me.

sum—v—

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vanRiemnOIOOOIOOIOIOOQOMarch22’197k IOODIIOOOOOIOOOOIIpageZ

visited Dorothy Krieger on March 15. She had
received the materials from Organon that day and was most pleased.
She described her program to me, and I found her more interested in
the periodicity of the phenomena and the clinical applications than
in any theoretic or psychologic phenomena. We could not find a
common groun for interaction but left with an agreement that should
we find something of interest we would contact one another.
6. I

and

7. Dr. Strand called me before she left for Europe,
I sent her the high dose (90 mg) OI-63 data from my laboratory.

The rest will wait until my visit. My best
please schedule sunshine for the first week of April

regards——
!

Sincerely yours,

Max

Fink,

N.D.

'

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                    <text>yaw/4

e

“mu-mvnwu—WWW—wvw

4-7.

w'wr’y'Wv"

.w .m'u—m-e-wr-n

—-..

m

m Int-new"!
r.

7,7

w

~r

mwm “aw—”wr—Wr.

"DJ-Hm

w.

Im‘er—vr

.m

.~

.v

March 22, l97h
Abba

Kastin,

M.D.

Endocrinology Laboratory

VA

hospital

New

Orleans, La.

Dear Abba,

I have read the latest protocol for the "ACTH h-lO study
of perceptual threshold and attention in humans" by Sandman, George.
and Ksstin, and will be pleased to submit this to the FDA. There are
some additional data that ought to be included, and I have indicated
some suggestions in my marginal notes.
The FDA has

studies (see

requested a progress report on the 01-63

letter enclosed). I

or your reports to

would

like to submit either a

copy

Riesen; or, a short summary of the data.
including numbers of exposures, dosages, tests employed, and a
description or the results. Either type of report will be acceptable,
I believe, and I will leave the choice to you. I am sending the same
request to Lyle Miller and Joyce Small.
Bank van

I have received a

copy

of the Miller et al.summary of the

earlier study. I find the results interesting but the absence of

the data

weakens the presentation.
him with some marginal notes.
Good luck

I have returned the original to

in your studies.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry
Max

1w -. P-v'nrr—w'yv'w it"s-WWW.” “to

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                    <text>21 March 1974

H E H

0

R A H D U H

To:

Arik Briaaandan, H.D.

From:

Max

Fink, H.D.

sabjact: Additional Funds (FY-74, 6th Qtr.),
LAAH vs. Hethadane Cooparativu Study
Additional funds in the amount of $6, 3&amp;0 have been

made

availabla for the tasting of brain changes of patients raceiving
levnlathadyl and mathadaac.

We have requested an EEG machine from General
Hospital
Equiplnnt, and these additional feuds should be used for the
following items:

1

Hewlettérackard tapa recordar, FE,
A-channnl, Model 39603, plus rack
mmt...‘.t..l.....DO...U..OOOOOOOO'OOI$‘585.00

l

Oscillator, Eewlett~Packard,

1

Oscilloscopa, Kawlett—Packard,
dual beam, Model léOB plus time

frequency range, Mbdal

m We].

low

20262..........

375.00

I‘GSA.0.0.0....IOOQIIOCCOOQ 1250.00

$6010.00

In addition, we will raquire the balance of the funds to be
used to purchase some small piecea, such as a tape degausaer,
couch, table, etc., which may be required in ordar to establish
a fully functional laboratory. A raquaat for these items will
follow, pending the purchase and receipt of the principal itaas.
HF/cis

�</text>
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                    <text>21 March 1974

José A. Yaryura~robias, H.D.
Secretary for Scientific Program
Asociacian Argentina d. Paiqnintria Biologic;
Parana 866/868
nuance Lites

REPUBLICA ARGENTINA

Dust Dr. Yaryura~Tbbiaa:
was pleased with your response to my inquiry and called
your nocrntsry to tall but that an would not up andh a program.

I

I have invitad eight participants; to far, five invitees havn
acccpted and on. has ducltnnd. I an awaiting the additional
tuspansca and hav. caupleted tho prapatation for the program.

I U111 write to you as soon as the panel has baen structured.
would
I
appraciate you: schtdnling the session on quantitative
EEG and psychopharnacoloxy.
Sincerely yours,
Ha: 316k,

3.9.

Professor of Psychiatry

Elicia

�</text>
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                    <text>21 March 1974

“.30
Wt.
mm
km:
Bayville, in for}:
3&amp;3
11

11709

Boar John:

I uhumd the EEG “:91: shown to an by my staff.- 911119
the frcqmuies an irragnlar and the voltages variab 1e, I an
not an anything thick, by itself. would ha considered patho—
logical. If ch: “:23“: 1| umtmtic, I would so no forth”.
than ha nhauld be can: to an ”‘If an sum-at 1: amt-matte,
propriate adieu).
ﬂy

but

”non.

raga-ch.
Sincerely yours ,
Eh:

Mg Mon.

Profauor cf Psychiatry
I!!! at:

�</text>
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                    <text>21 March 1974

Gerald L. Klerman, M.D.
Erich Lindemann Mental Health Center
Government Center
Boston, Massachusetts 02114
Dear Gerry:
Thank you for your kind comments regarding the APPA. I
think that the Association should consider the suggestion of

developing

its

own

journal.

I have taken your suggestion of a review of the ECT literature to heart. I had completed a review of the proceedings
of the conference on ECT and will now add to it a specific re—
ECT

clinical results.

view of the

Thank you for your suggestion.

In talking to you about yOur relationship to the FDA, I
because, as I mentioned my letters
to Gardner and Scoville regarding the use of ele—trographic
measures for bioevailability, you seemed never to have heard
of this question. In checking my files, I find that my letter
to Gardner of July 16, 1973, and my letter to Scoville of December 20, 1973, have not been answered. My files indicate that
I sent a copy of both to you on December 20. Perhaps one of
the actions of your committee might be to provide closure to
suggestions such as this, for at least it will mean that some
consideration has been given, even if rejected.
was momentarily embarrassed

Again,

my

thanks for your comments.

My

best regards,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF/cis

�</text>
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                    <text>n—

A

w

20 March 197&amp;

..

....

..,

vawmwp...

‘M:-'r_lw'il‘."";'wnv'~.

Mt. Snmnal

Pilato

Department of ?Iyeholegy
Boston University
6k Cunningtan Straat
Boston, Mustachunutto 02215
Dear Mr.

Pilato;

Encloaad

is a

copy of the

prosantatian that

you requcoted.

studies which I ha»! quoted were done morn than ten years
I undertook studias of unilnteral and bilateral conago.
vulsivu thurupy, I did not includd language measures. I do not
know of anybody also who has. but I do beltevu that a study using
syntactic and TTR austere: 1n patienta receiving unilateral ECT
should praacnt differences whether the aloctrodea word on the
The

When

dominant or nonudomiunnt hanisphcta.

.tudyo

It

would be a very good

'

luck in your atudiaa and my best regards to
notsky and Allan Mirnky. should you know them.
Good

Conan Kor—

Sinceruly yours,
Max

Pink,

M.D.

Protassor of Psychiatry

MP/cis
Baal.

�</text>
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                    <text>20 March 1974

Robert DuPont, M.D.

Dirootor
SADDAP

and HIDA

726 Jackson

Placo, u.w.

washington, D.C. 20500
Dear Dr. DuPont:

days ago, I received an inquiry from Jon Volavko, H.D.,
hood of tho nourOphyoiolosy division of the Department of Paychiatry, Now York Medical College, regarding ohargos for pro~
cousin; of EEG data. He indicated that he had proposed to SAODAP
that his laboratory process rocordo in tho SADDAP Collaborativo
Hothodone-Lovomothodyl Study. As a juutifiootioo for his budgetary
request, be indicated that using our facilities Would cont $100/hour
for machine time for processing.
Two

I um'writing to indioato that thin to a gross error. This
laboratory was established by tho ﬁattonal Instituto of Mbntal
Health. and no have prooooood data of intorost to that Institute
as wall as to NIDA at oithor no direct cost; or, where funds were
available, at rates from Sllrocord to $5.50/hour. HSMThe latter
é2~70—98,
chargo in tho one that has been used in Contront
and is well bolow the ontinato approvod by the contracting of~
ﬂies: in 1970.

In July, 1973, following mootingo of tho V.A. Study Group
and Morhodono, I submitted a letter, dated July 27. 1973,
to Dr. Sam Kain indicating tho costs which I projectod would be
incurred in oollocting and procoaoing tho V.A. lovomothadylvmotha~
done data. A copy of my budgor of that dato is attached. You
will note that the principal coat in equipping the laboratories
for proper recording. Hora, too. on indicatod that our cost was
$5.50/oooh1no hour, but booauoo of the proposed duration of
rooordinso and tho mothod of collection. we oorioatod a cost of
$1,000-1.200 for 90 Iubjocto rooordod at 4 separate occasions,
ouch occasion of 30 minutoo' duration.

for

LAAM

~1-

�" --- yr

"V" n-

pr-w"an n:

:m‘w’v-HI- vk-‘v‘r'v-

quuat-‘wwr-K

1w. mu...“

. .

,. ”Fm.

7’

.«ﬁ...~....w,....(_m',_....,,d_w..

WA.

.31....

W

‘-.,

”M. Mr r.rr.w--.‘~,

.,._.

,vn “my",

21.... be advised that this not: is vrtttan not as an offer
:9 pgrtieipace in your study program, but to elnrtfy a groan dis—
tortion in quatacion 3560 by my format unionists. I would be
{ztnt;fu1 1! yam vauld dirncc this information to tha appropriate
offiuor in your organisatiun so thgt tha records can be enrrecccd.
Sinccraly yourt,
Hm:

rink.

H.D.

Protannor of Psychiatry

HI/ais
Baal.

�</text>
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                    <text>20 March 1974

Mr. Soonel

Pilate

Dopartmont of Psychology

Boston Univoroity
6o Cunnington Street
Boston. Massachusotto 02215

Pilate:
Encloood is a

Door Ht.

copy of tho

presentation that

you requootod.

otudioo which I haw. quoted worn done more than ten years
I undortook studios of unilateral and bilateral convulsivo thorapy, I did not include lanauogo uoaoutoo. I do not
know of anybody also who has. but I do holiovo that a study using
syntactic and TTR measures in patients toooiving unilateral ECT
should present differences whothor tho cloctrodos veto on the
dominant or nonndoainant homioﬁhoro. It would bu o vary good
The

ago. when

Ittﬁy

0

Good luck in your studios and my best regards to Canon
notoky and Allen Miroky, ohoold you know them.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

HF/ois

ﬁnal.

Kor—

�</text>
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                    <text>20 March 1974

Dr. mad. Garner

M.

Klinilche Porodhung

Enrrmaan

Hoaropsyahopharmnkologie

Scharinz

AG

55
65 03 11

D—l BERLIK

Postinch
GERHARY

Dear Wernar:

Dr.

covur,
work.

I

Itil
am

asked mn~tc send you puma narcan. Under sepnrate
sanding you 10 ampules, as you requastod.

You may

prefer to as: pure naloxona

I will be glad to supply that if

you used.

With

powder

you'will

for

any syatamatic

tell

as

how much

best regards,
Sincaraly youts,
Max Fink. M.D.
Professor of Psychiatry

MF/cis

�</text>
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                    <text>20 March 1974

313 Bun: Duvalopncnt Company
P. O. Box 597
Stuamboac springs, Colorado 80‘7?

Genclauan:

I van undblc to atunnd tho Winter Confarqnun on Brain Emu
my rnsatvauion after paying a d¢p¢ait of
$50.00. I anticipated rtfund of this #09031: but havu not yet
racoivnd one. I balievn my cancallatiou was and: in dun tin».
search ana caudalled
Thank you

for your nttantion in this matter.
Biuearaly yearn,
Fink, 3.9.
Profassor of Psychiatry

Max

Mrlcia

�</text>
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                    <text>20 March 1974

Thomas A. Bayou, M.n.

Office of the Deputy Diraccor

Divinion of Mauropharmacelogical
Drug Frodu¢ts

Officn of Saicntific Evuluatioa

at Drugs
Food and Drug Administration
5600 Fishers Lane
Rockvillc, Hltyland 20852

Bataan

Dan: Dr. Sages:

'

Ra:

me 8569.

01w63

I havn recaivud additional information with regard to the
placebo natarial to b. used in our studies of OI~63 undar IRD 8569.
Since tho rnvtuw is «£111 in procaca. I nu submitting this add1~
tianal information for your considnration.
slnearely yours.
Fink, M.D.
,th
Pratt-sot of Psychiatry

“Plait
Att.

�</text>
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                    <text>20 Hatch 197&amp;

Edward

J. Sachar,

K.D.

Departnnnt of ?syeh1a:ry

Hontaftora ﬂoapttal
111 East 210th Street
Etonx,

New

York 10667

Dear Ed:

Charlia has told

me

of your accepting chairnanship of the
Congratulations!

1975 APPA Program Connittae.

During the past twa years, I havn became intareatad 1n the
affects of burnout: on brain function. In our studio: I haw:
became acquainted with tag scientists from abroad who I would
like to command to you for consideration in the program.
David dn Wind, M.D., Protaaaor and Chairman of the Depart*
nant of Pharmacology at the Univnrsity of Utrecht, has bean a
vary signiticaut peruon 1n assansing the role of peptides in
unwary function.
Hank van Biasen,'m.n., is 00G of his atudenta, who has bacn
taspanniblc for the pharmacologie aaaaya of paptidas derived
from ACTH. He works at §.V. Orgaaan, Gas. Holland. Both of
those nan speck excelluntly. and should you teal that a preacn~
nation from nicks: of them would be useful, I an optimistic that

they

will participdta.
I am also sure that

you are acquainted with tha recent work

affocts for a variety of

of Turan 1:11,
sex hormone: and their antagonists.

who has demonstrated cus

Again,

my

congratulationn, and

my

bus: regards,

Sinderaiy yours.
Max

MF/cin

Fink,

M.D.

�</text>
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                    <text>,19 March 1975

Albert A. Kurland,
Director
Mnryland
Box 3235

M.D.

Psychiatric Bosaarch Cancer

Baltimore, Maryland 21228

has:

A1:

I regret that I do not know any biochemist of sufficient
dilcinccian to recaauand for this position. If I warn looking
for such a person, I would prdbdbly call Arnie Friadhaff at
Maw York Uhivaruity or Ed Sacha: at Cha Albort Einstein 0011333
of Mndiaine.

With ragard to the ECT projact, I would be delighted to
read ch: ruport bcforu it is submittod.

interuutnd 1n gutting a capy of tha new1y~1ssucd
volumn, quehobiqgggy of Connuisivagrhcrqu, which has just bcan
published by V. H. Winston in washington.
You may be

my

bus: ragarda,
Sincerely yours,
Max

Fink,

M.D.

Profnoaor of Psychiatry
MF/cil

�</text>
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                    <text>19 March 1974

Robert Spitaar, M.D.

State Psychiatric Instituto

ﬂow

York

New

York.

722

“but 168th Street
New

York 10032

Dcar Bob:

Enclosad is a copy of the raport, "Brain Function, Verbal
Bchnvior. and Psychothcrapy." for consideration for the APPA
volumn.

I shall try to provido a prettcu within the next
cats 30: Zubin's suggastion.

and V11;

few days

I want to take the opportunity to thank you for satting
such a fine matting. If ch. rest of the Association anjoyad
as much II I did. then it was not: successful.
My

beat regards.
Sinccraly yours,
Fink, MODQ
Profcacor cf Psychiatry

M33

MF/ci:

Encl.

up

it

�</text>
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                    <text>19 March 1974

Robert Spitaar, M.D.

State Psychiatric Instituto

ﬂow

York

New

York.

722

“but 168th Street
New

York 10032

Dcar Bob:

Enclosad is a copy of the raport, "Brain Function, Verbal
Bchnvior. and Psychothcrapy." for consideration for the APPA
volumn.

I shall try to provido a prettcu within the next
cats 30: Zubin's suggastion.

and V11;

few days

I want to take the opportunity to thank you for satting
such a fine matting. If ch. rest of the Association anjoyad
as much II I did. then it was not: successful.
My

beat regards.
Sinccraly yours,
Fink, MODQ
Profcacor cf Psychiatry

M33

MF/ci:

Encl.

up

it

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                    <text>w: “w ...

»

"1»

an.”

«‘

mun,"

a

.__, -r»4(«

-—.-»

”Warwr FW—v‘u‘w’r‘u’ ”v“. w m

19 March 1974

Joseph Jaffe, M.D.
ﬂaw York Stat. Paychiattic
722 West 168th Btrcot
New

York,

Haw

Institute

York 10032

Dent Joe:

I nisand

convocatian.

you

in Boston at tho

APPA

and again cc the Bendor

Enclosed is a copy of my presentation to thc APPA. in which'
I havc taknn the liberty of quoting you dttnnsivqu. I hops that

the

later datt
‘My

havn not

vitiatod the conclusions of

1960.

bﬁlt regards.
Sinccrely yours.
Pink, M.D.
Professor of Psychiatry
Max

MF/cis
Baal.

�</text>
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                    <text>19

“3::

L.

March 1974

m, Ptho

Departunnt of Psychiatry
University of Chicago Medical School
950 East 59th strect
Chicnso, Illinois 60637
boar Bob:

I am citing the libarty of sending you a copy of the papar
I just praaaucod a: the AEPA. When I was faced with the prdblnm
of dsvnloptng a prcsentation on the ginoral subject of "Evalustion
of voychochcttpios," I alocted to resurrect the work which no did
not: than a decade ago.
You may also be plugged to know that tha volunn. Pszchobiologz
of Canvulatvn Thargay. which pruacnts the proceedings of an RINK»
:ygportad confgrcnca in 1972, has just been publishcd, You may be
pleased to see your work extensively quotad.
My

bunt regards,
Sinccrcly yours.
24“ Fink; MID.
Proﬂessor of ?¢ych1atry

Mflcia

Encl.

x:-

:rvyympwmn-

.

w,-

.

�</text>
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                    <text>19 Mnrch 1974

Pollack, Ph.D.
anartnnnt of Psychology
Qunens Callas: of tha
City University of Saw York
Flushing, New York 11367

Max

Dear Max:

I am tuking the liberty of sanding you a copy of the paper
I just presented at aha AP?A. When I was flood with the problum
of developing a prastntation on the gun-r31 aubjcc: of "Evaluation
of roychoeherapial," x alactcd to resnrtacc the work which we did
more

than a daaadc ago.

You nay alto be pleased to know that the valuma, Pnzchobiologz
Canvuluivu
cf
Thornpy, which prosantc the proceedings of an RIME—
supported conlcrnnec in 1972, has just been published. You may bu
planned to sue your work axtanuivnly quoted.
Hy

best regards.
Sincerely yours,
Max Pink, M.D.
Ytofelﬂot of ¥aych1acry

M?/cis
Baal.

�</text>
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                    <text>19 March 1974

Houston,

E. A.

24.1).

Professor of “ontology
Sinai Hospital Bchool of Modicins

Mount

Fifth

How

Awooos and 98th

York,

How

Street

York 10029

Door Ed:

I

wont to thank you

Morris Sandor.

It

for inviting

no

to tho presentation for

in unfortunotc 3hct you second diusppoiutsd

1n the proscntation that Martin and I mode. You mcy toccll that
martin tscoivsd co invitation and I hsd not; and in response to
his toquost. I supported the ptoscntttion of tho 088 material.

I as taking the liberty of enclosing a draft copy of c pros~
notation I had undo two weak: one at c coating of the Amctican
Psychopathologicol Association. Encouraged by the subject of the
contoronos, "Evaluation of Psychothctoptos," I wanted to bring
to tho sttontion of this audience tho work which we had dons
sons goats outlier on tho relation of brain function and psychothcrspy. The theoretical model presented to a b1t.sttnincd,/but
I have no doubt that the continued oxplorntion of tho linguistic,
attitudinal, and pctccptusl changes with psychoactivc drugs pto~
video a spacial opportunity for undsrstaudtng tbs changes in the
dyadic tslctionship, oftcn ussd for thstopsntic purposoo.
My best regards.
Sincorcly yours,
Max

Fink,

M.D.

Ptofcssot of Psychiatry
MF/cto

Ecol.

�</text>
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                    <text>19 March 1974

Isaac Marks,

M.D.

Institute of Psychiotty
do Groupigoy Park
Dcnmork,ﬂill
London 8E5 8A3
EEGLARD

Door Dr. Marks:

First, lot no thank you for your participation in the APPA
settings. You: contribution was vary helpful, and I trout that

you cnjoyod tho ocooiana as ouch on

I did.

I havo rcod the proposed rosoaroh program untitled

youtio Studio: of Booiotant Noutoooo."

"Thora~

yroposcl is an ambitious one and should make significant
contributions to the trootmont of thooc complex problems. From
the point of vicw of poychoohormccology, I can one no inherent
rationale for tho study of clooiprooioo. From the evident: avail~
oblo to no, this is on octivo thymolcptio, prdbably indistinguishable
from imipranino. Tho study will doiino tho efficacy of this
compound and will soroly juotify the invoatuont.
The

the point of viow of nouroohyaioioay, I bcliovo that
in a much stronger position to dofioc tho rolo of
the pharmacologic ngoot in tho trootooot process if you could
specify that brain changooudid or did not occur, the dcgrco to
which tho changoo wore contained, and tho relation to tho troutuont couroo. A: I iodicatod in my lecture, I bcliovo that thorn
in a good tolationohip botwooo bohaviorol changos and nouro~
physiologic offooto in ECT, and with psychoactiVo drugo. Should
you be able to racetd EEG signals in a oyotoootic way, undo:
roooonobly woll—controllod conditions, your cloctrooocophologrophor could quantity tho EEG ohangoo and provide you with an
indopoodout nocouro of drug affect.
From

you would ha

-1-

�rm-

«-..-v

Ava“):

wwmrr

I. Markl‘

19 Match 1974

~2~

M.D.

Should you not have facilitias available at Denmark Hill,
wuuld be glad to coopnrata and provida you with quantifina~
tion of tapes; if these are «ollncaad in a ayatcnatic way. under
canditiana which permit us ca nuke tho measuranant. To c01ldborata with this laboratory would regatta thnt you havu a tape
system cangntible with aura, amplifinrs which era of ransonnbly
high.qua11ty, and a teghniciun who undnrutanda eh. presentation‘
of 339 data for quantitativu mcaaurcunnt. Thar: axe rwo technicians in tha Landon urea and, dhauld.you be intotcntad, I can
string: to: your technician to be superviaod by cithcr of those
um

units which

new

at: caapnratins with us.

During uh: pat: year, I have bacon: particularly interested
Eh.
in
psychoactiva.prapert1us of a tttraeyclic campaund. nianu
auxin (GB-94), praaucad by H. V. Orguuon in Holland.' We bilieva

that niunnariﬁ is

rapidly aetivn than anitriptyliue, with
fiﬂit scdntivu tad taxicholincrgic effects. Should you be intaraatod in alias this compound.rlthcr’thtn annthar in your emu
periunnt, I would be.gind»£o propose to the pharmneoloxistn at
mere

Orgauen that they canaider providing you with such equipnnnc as
gay bu unctul far a cbllabaraciaa.

I

hopu ynur weak;

.My

best rugsrds,

in Israel are fruitful.
,

Sincerely yours,
Max

rink,

M.D.

_

Ptofcsnnr of Psychiatry
Mr/cia
Baal.

�</text>
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              <elementText elementTextId="93305">
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                    <text>19 March 1974

Edward (2. Sunny. M.D., Ctr-Charm
Drug Abate Coutctunoa
Hhacun of Scinnca and Industry
57th Strcet and Laka Shore Drivu
Chicago, Illinois 60637

national

Dan: Ed:

I vary much rcgrat that I will be unable to att.nd thav
Racianal Drug Abuna Confsrenca. as I am schcdulod to ha in
Europe

at that tins.

I havn no roservntioas 1n ruccmnanding my rcpllcsmnnt at
tho ﬂaw tart Mndical Collage, Richard Rennick, M.D., to subotitutn an my behalf. should you approve, yea may reach him
at (212) 369~7900 or (212) MDZ~1899.
my

best wishes for a succauaful conferencn,
Sincarely yours.
Mn: Fink, M.D.
Professor of Pnychiatry

M?/ois

�</text>
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                    <text>19 March 1974

Albert A. Kurland,
Director
Maryland

Box 3235

M.B.

Psychiatric Raseardh Center

Baltimore, Maryland 21228
Daar Al:

biochemist of uufficlant
I were looking
distinction to tecommand for this poattlon. If Friodhoff
Arnie
at
would
prdbably call
for auch a person, I
College
Einstein
Alhart
Ed
the
Sacha:
at
New York Univarsity or

I regret that I

do

not

With regard to the

ECT

know any

of Mudielae.

rcaﬁ the ropart before
You may be

it

interuatad

project. I would be dellghtdd to
is submitted.
1n

gutting a

envy

o: the newly-insued

volume, Puzchobiologz of Conuulalvn Theragz, which has
published by V. H. Winston in Waﬂhington.
My

just been

best resardn.
Sincerely yours,
Fink, M.D.
yrofunsor of Psychiatry

Ma:

MF/ciu

�</text>
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                    <text>19 March 1974

J. Sachnr, M.D.
Dopartucnt of rsyohiotry
Monastiore Hoopitol
111 Ellt 210th Sttoot
Bronx. New York 10k67
Edward

Dear Ed:

Chorlio has told no of your accoptias thatrnunohip of tho
Congratulations!

1975 APPA program.

During the past ﬁve years, I have become tnuorootod to tho
on brain function. In our otodtoo I have
become aoquoiotod with two scientists tron (brood who I would
11k. to rooounnnd to you for consideration in tho program.

affects of bottom-o

David do Hind. H.D., Proton-or ind Chairman of the Dopartn
non: of Phoruooology at tho Univoroity of Utrecht, has been a
voty signifionnt potion in attaining tho role of paptidoa in

unwary function.

is one of his otudonts, who hon been
tho
for
phormooologio
rouponoiblc
assays of a series of peptides
dcrivod from ACTE. He works at K.V. Organon, can, Holland.
zﬁothaof than: non opook oncolloutly, and should you fool than
a prouontozlon from oithor of then would he usaful. I on op~
tiaiatic than they will participoto.
Honk van Bianca, H.D.,

Itil,

I

on

not. you ore acquainted with tho vacant

who has dononntrotod CH3

hormonoo and choir

Again.

my

antagonists.

work of Torso

affects for a variety of so:

congratulations,

and

my

boot rugardo,

sincsroly yours,
”‘3 Fink,
Elicia

MbDO

�</text>
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              <elementText elementTextId="59843">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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              <elementText elementTextId="93308">
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                    <text>19 Mirth 1974

mm-

H

'1

mm-

pray:

sqmgeup

Charltn sangaau. 3.9.
-Prnnidnnt
Annriann Paychapathologtcal Anaactatian

Rantarn Panamylvanin Psychiattie Inatttuco

Pbiladulphtn, Paunlylvunia
.3.

Dog: Charlie:

ragarwwvz'yww.

Tb
w!

19129

Enclosed

ch: heat at

is

a eopy a! the nouinationl for APPA cumndttccs.
roanllncttoa. cvnryona nominated sccaptad.

my

1;»;

4
$2:

'tw-mx

m

I an 136.06 dnlijhtnd that Ed Saahcv will be eh. Chairman
of the next Frost-a Conﬂict... Enclosed is a lcttur for you and
Ed for your connldnration for thu progrun.
My

‘mﬂ‘ﬂ'm.

best rsgnrds.
Sinunraly yours,

huh-W5-

an,

m ﬂnk' HOD.

‘

mien

1"

"‘3‘"

£9215

rs,

u
2

MW».

-

_

�</text>
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                    <text>-;

Marin-m-

18 March 1974

Johns Hopkins Praia

Baltimor-

Harylnnd 21218
Gantlanon:

I ta internutad 1n recounandins ch. valunn, Drugs and ch.
vBrain, aditcd by P. Dinah, 1969 (LC 68~31662). for an: in a
Icaintr. "Brain nnd Behavior," n: tbs Baalth Satancoa Cantor.
Ha: Dr. Bluek intend a incur :ditian? If so, um wenld upprcciato a

trial

aopy.

I! not. picaln

faculty

use and

bill

sand us a copy of the 1969 edition for
an

dirnctly.

sincerely yours,
MIX

Fifth,

HOD!

Profcssor of Psychintry
Contributor

Hrlcis

�</text>
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Prof. Canton Stofonlo
Doportnont of Payohtatry
Univotolty of Athooo School of Modicino
Eginitiou Hospital
76, Voailliooio Soohio Ariana

Athono,

GREECE

Door Cotton:
Enoloood is o copy of tho critique provided by Dr. 8332:.
of tho ounnorioo submitted for that: roviow ct tho and of January.
Thoir concerns noon cannot. and I treat no V111 be able to respond.

to be in Burupo 1n curly April or. still curront.
Assuming your availdbtlity, I am planning to lonvo Gorunuy on
April 11, arriving that ottoruoon. I on avoilobln until April 15
or 16, as I hsvo o locturo in Washington on April 17.
ﬂy plono

roe-n: stating, I dioouoood our publishing mood: with
Vrlt: Froyhoa, tho oditor of Cogngohenoivo Payohlotty. Ho
1: ollowod to 13:3. "toplcnl looozﬂgvolunoo, Ind was intorostod
in publishing all roportl in out or two inouoo of tho journal,
as wall so ro~1oou1ng tho artloloo plus oppoadlooo on o hord~
cover volunn. Ht. roooption'uoo to fovorablc that ﬁt any oon~
older this no a tonllotic oppottunlty.
At o

Dr.

are progressing with tho data anolyoio of tho withdrawal
otudy, and I on optimistic thot I can bring thou. with no.
Ho

I trust

boloro the
My

you how: rlooivod oonfirootion of tho
on May 9.

APA

ottooatotton

boot rognrdo,

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m Fink. H096
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                    <text>“7‘ &lt;—-,-.-

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lﬁ Hatch 1974

SW: Katy.

MOD.

Protaucor of Psychiatry
Harvard Mndienl schaol
Massachuaoten Ganortl Hospital
Yruit street
-Boocon. Natanchunctts 02114
Dan: soynour:

Bolton oa.uians of tho Anarican ?tyehopatholoslea1 Association.
Yam

chnuld ouch rucnivu five c0911: an algtor~cantributorn.

I an analouin; nous cards for distribution, should
m.fnlo

yum

find

chwaa

I

I an plugged with tho volunn, and‘I hop. yea arc altos I an
grataful for your collocttvu and individual advice, attainina,
and contributionl-und*¢an enly say "Thank you."'
My

bCIE

regards.
Sinnartly youri,
MIX

MF/ais
Enﬁlo

'6: 3m- Mﬁmm,
Thomas A.

211.5.

Williamt. H.D.

ﬂﬂk .‘ ”uni

�</text>
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                    <text>STATE UNIVERSITY

or

NEW YORK AT STONY BROOK

HEALTH SCIENCES CENTER
School of Medicine

'1

Stony Brook, N. Y. 11790
Phone: 516-444-2413

Department of Psychiatry
13 March 1974
Mr. Stewart Alsop
Newsweek
444 Madison Avenue
New

York,

New

York 10022

Dear Mr. Alsop:

conclusions regarding the use of opiates in dying pa—
tients, quoted in the New York Times of March 5, strikes a res—
ponsive chord. I am a national consultant in opiate research
with experience in studies of heroin, and I am frequently called
upon to answer disturbing questions.
The

Physicians ask whether heroin may be used, its safety, and
their risks are with regard to the Federal Internal Revenue
Service and the Bureau of Narcotics and Dangerous Drugs. I have
to answer that they may not use heroin; that even for research
obtain permission and supplies; and that their
it is difficult toBNDD
IRS
and
fears of
are probably groundless. But I am not sure
about the latter statements, recognizing that in their asking,
the physicians are reflecting a fear that may be founded on

what

history.

Because experience with opiates is limited, they tend to
use dosages that are too small for fear of developing 'dependenee,‘
thereby under—treating their patients. This attitude reflects on
our education and on the proscriptions quoted in our journals.

I have used heroin to treat relentless pain and have found
it is quicker in action, more effective in response, and
has fewer side—effects than morphine. As you have suggested,
the mood—altering qualities are particularly gratifying.

that

Your reference to morphine and heroin brings to mind the

reports that other opioids, particularly etorphine (M-99) have
been tested and are even more effective than heroin; that they
are probably 1000 times more active on a dose basis~—but studies
-1-

�Mr. S. Alsop

13

—2—

March 1974

w‘

.

aha-vat.

are proscribed by authorities in the U.S. and Europe for fear

that the

Afor man.

it

'instantly addicting' and too dangerous
Its use is limited to animals, where (as Immobilon)

compound may be

is used to capture non—feline mammals. (For a description
of its use in patients, see the reports by Blane in Agonist and
Antagonist Actions of Narcotic Analgesic Drugs, Ed. by H. Koster—

litz.

London:

Macmillan, 1972.)

Not only should heroin and etorphine be made available for
found useful, allowed to be
prescribed by physicians for patients with intractable pain;
but we should be willing to make these substances available to
patients with instructions as to the consequences of‘overdose,
so that they haVe an opportunity to self-regulate their dosages
as needed.

clinical analgesic studies and, if

Your

efforts at liberating these analgesics for medical

uses are to be encouraged.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>_...

March 12, lQTh

'v-vvv-vv

V's-Irv

"v—IW'

nwwwu

m

‘I-w-I

-‘..m~.—wv.m

Robert hunt, M.D.
Massachusetts Mental Health Center
7h Fenwood Road

Boston, Massachusetts 02115
Dear Dr. hunt,

Enclosed are two recent summaries of the work which is
currently under study in my laboratory. The xerox copy of the galley
proof is a report in press that I completed in January, 1973; the
preprint a capy of an address that I made in Holland in October,
at a convocation reviewing the recent progress in developing new
drugs, particularly the development of mianserin (GB‘9h). .There
is some redundance in the two reports, occasioned by the different
audiences, but these will give you some idea of the problem.

It is

my

intention to develop a collaborative program,

bringing together the chemistry and pharmacology of industry; and
the interest and enthusiasm of the university. The focus will be
in the ebaluation of new compounds for psychiatric purposes, as well
as refining the methods of this evaluation.
While much of our work

pharmacology,

we

is dedicated to clinical psychointerests to studies of

have applied these same

convulsive therapy, cannabis, opiates, and Opiate antagonists.

March 23.

I look forward to discussing the program with

you on

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

a copy of your curriculum vitae.
reimburse you for the expenses of the visit.)

P.S. Please send

me

(We

will

�</text>
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                  <elementText elementTextId="106932">
                    <text>'Jr—lz-"rm ww—

WV”: ’-.'

,_.__
.,v- - r,

W ,m '1, wm‘“

-V

'nrv-‘J‘4'Y: no;

,
.... “r..."w" _,,_,~_,._,
.

.

H.

.. ,. "ﬁt-rm

,

V

mn— ..

,

“("4

n. u.

,y. 3.7-.-....;.7—w

.,

«v

‘—

q

.1

-

c

7.

,.

7483—09183

5

March 1975

Richard Rnsnick. M.D.
Department of Psychiatry
New York Medical College

East 102nd Street
Now'York. Now York 10029
5

Dear Richard:

I am pleased to confirm the arrangomont whereby tapes con~
taining EEG information collected at tho New York Modical College
laboratories can be processed at the computer facilities of

Stony Brook. The programs which we dovelopod at the New York
Modicsl College are available, and VB will be pleased to assist
in the program,
you in the analysis of the data to be collgctod
"
"Studies of Cocaine in Man."
my

best regards,
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis
cc: I. B. Schwartz

‘I‘

�</text>
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                    <text>:ercuﬂf‘mﬁllz;

av

«‘Mﬂl'lgﬂﬂn‘ﬁ‘w

wwwﬁw—wvzmmmrwr

15¢?“er

“vi/3r

Irvww

7458-09083
4 March 197é
Edward

J. Callahan,

Ph.D.

Research Specialist and

Assistant Clinical Professor
of Psychiatry

U.C.L.A. School of Msdicins

Csmstillo~ﬁouropsychiatrio Instituts
Rosssrch ?rogrsm

Box 'A'

Camorillo, California 93010
Dear Dr. Callahan:
Thank you for your invitation to participate in your
research program. I have read your project proposal and it is
indosd interesting. I would be delighted to serve as s con~

sultant.

I so enclosing a recent

summary by Wiklsr which may augment

your formulation, as wall as a copy of

my

vita. as

you requested.

Sincerely yours,
kink, M.D.
Professor of Psychiatry

Max

Wlois
Encls.

�</text>
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                    <text>m

ermam'-.—.w_—m.w
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March 2, 19Th

”'m'ﬂ’www‘rprwuvqam.

E
E
'5

Philip

Bookmsn, M.D.
Hermann LsRoche, Inc.

Rutley,

New

Jersey

E

§
E
y

Dear

Phil,

3?

¥

I very much enjoyed our discussions on Thursday, and I
thank you for the invitation. The final report on thebe diszepnmcompleted
bromszepam-plscebo EEG and bloodllevel study should
the end of the mbnth and sent to you.

by

In checking my files, I found the enclosed report by Dr.
This report answers some of the questions raised about the
Itil.
evaluation of thymoleptics and antidepressants by neurophysiologic
methods. I spoke to him and he was pleased to have me send you this
copy for your information.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

�</text>
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1

M

E

0

M

March 1974

R A N D U H

To:

Marvin Kuschner, M.D., Dean, School of Medicine

From:

Max

Subject:

ADA

Fink, M.D., Professor of Psychiatry

appropriate, if it has not already been done,
for the School of Medicine to establish an AOA section. ADA
has been used as an incentive for excellence in study in other
institutions and may be useful here as well.

It

may

be

If not yet established, perhaps your office could inquire
of the faculty how many are already members to determine if a
sufficient nucleus exists for the development of such a unit.

MF/cis

IIIIHIIAL‘

�</text>
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                    <text>74$B~08888
1 Mhrch

M

E

M

0

1974

R A H D U M

To:

Horvin Knachnor. M.D., Boon, school of Modioioo

From:

Max

Fink, M.D., Professor of Psychiatry

Subject:

VAR

Northport

In your discussions with the faculty of the Department of
Psychiatry some weak: ago, you highlighted the importance of
the facilities at VAR Northport and our rolationohip to that
hospital for the dovolopmoot of this school.
The following capsular history may be holpful in your
tiouing negotiations with that institution.

con»

In tho spring of 1972, Dr. Yolles and I obtained support
from the VA Control Offioo for the catnblishmont of a drug do~
pondonoo treatment center. Like Venus rising from the sea, the
unit was established on July 1, 1972. By October, 1972, the
ward was staffed; mothadono maintenanoo. narcotic antagonists,
and detoxification for opiate dependence wore all provided by
a staff that had been wall trained; and additional funds had
been awarded by NINE for those programs.
By

tho tumour of 1973. Hard 663 had boon renovated and a

fine facility established.

'

During that same cannot. we notod that the number of opiatedcpondont subjects in the community had boon reduced (part of a
national phonomonon), and we discussed with Dr. LoCerva the cd~
mission of patients with alcoholism in that unit. Approval was
granted, and since September 1973, we have run a census of 75%
alcohol abuso pationto and 25% opiate-dopcndont.
”1"

�W

”2-

W1
March 1974

Last July, we became participants in the national
loborativo Study of Lovonothadyl and Mothadone.

VAH

Col~

This program has continued to develop until Wednesday,
February 27, when Dr. Briasondon and I wore peromptorily noti—
fied by the new modicnl director that the funding for this unit
would terminate on June 30, 1974, and that wo should not ac-

cordingly.

Aftor considerable discussion with the

new medical

director,

I boliovn that on were able to convince him that, althOugh tho
discontinuation of this unit is feasible and can be accomplished
readily, a two-year investment giving life to it was worthy of
some discussion. Ho agreed and ousgostod that ho would roviow
the programs in Washington.

like to indicate that we wont through a similar
tho
curtailment of funds in l973. and on wore able
in
crisis
Whohington to our satisfaction.
intorvono
in
to
I

would

In our discussions some weeks ago, you aokod for any information which might onhanoo out rolationnhipa with the VA.
Thooo ovonts nova been distressing, to any the least, and
while maintononco of this unit for some additional months is
highly likely, I wonder if this capsular history does not reflect
the lack of a significant portnorohip between the VAR and the
Mbdicnl School. If Northport is indeed a Dean's Hospital, should
not the creation or destruction of programs be a matter of con~
corn to the Bonn? In it proper, in your conception, for pro~
grams to be amputated without discussion of their significance
to the touching and research programs, as well as tho treatmont
of patients?

Fortunately, Dr. Yolloo anticipated the sequence of ovonto
and has provided the Department with alternate teaching and
research facilities at another institution. Perhaps you will

understand now why this faculty encouraged this relationship
will continua to do so until hotter faith is shown by the
VAR Northport.
and

NF/cio

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                    <text>WW.»W'4W~'IV/P«V'V‘KWV':Krn-

.-.H~.,v

w ,m. u...“ ,.

..,......, i.-.

w."

.,,

.

,7

W

,

_,

SePtem'ber 25, 197k

Jack F. Wilder, M.D.
Chairman, Department of Psychiatry
Albert Einstein College of Medicien
Bronx, New York
Dear Dr. Wilder,

I am writing in support of the recommendation for promotbon
William
Karliner, M.D. to Associate Clinical Professor of Psychiatry.
of

Bill Karliner since 19h9, when I was a resident
at Montefiore hospital and he was a young attending physician. Over the
intervening years, I have had occasion to refer patients to his care,
and to follow his studies of somatic therapies with interest.
I

have known

In 1967 1971, I was responsible for a systematic study of
in patients at
unilateral and multiple monitored convulsive therapy recommendation
of
We
the
on
dependent
were
Gracie
Hospital.
Square
the
the practitioners of their patients for our studies, as well as their
willingness to cooperate and to achieve the cooperation of their
and
patients for extensive studies of EEG, psychological tests, be
among
follow—up studies. Throughout the period, we feund Bill to
data
the
by
we
and
were
regarded
the
of
most
staff,
cooperative
the
which we eventually published in the scientific press.
—

In these associations I have feund Dr. Karliner to be an
enthusiastic clinician with dedication and patience, a keen research
enthusiasm, and capable of relating well to patients, staff, and re—

searchers. His fine reputation

known

to you.
I

am

among

the clinical community

is well

pleased to endorse a recommendation for promotion.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>September 2h, 197h

Mr. Berton Roueehe
The New Yorker
2h west h3rd Street
New York, N. Y.

Dear Mr. gouache:

are sure to write about your article, "As Empty as Eve”,
to sympathise with Mrs. Parker and to praise your presentation. Some
will write to criticize the errors of fact and of experience. I am
writing to express my sadness that you have chosen the public press
to air a single medical case report, without the leavening of
clinical experience, which would permit this case to he ’eeen in the
context of the goals, successess and failures of this therapy. I do
not understand what service you uere attempting to offer, but surely you
.ghaVe added.your powerful voice to the many who fear that vh1ch they do
I_not Understand, thus making_it more difficult for patient 5 Who may be
helped to receive treatment.- YQn are encouraging many patients to
I.veehs and months of the unnecessary hell of a severe depression; and
even some to a suicide that may have been prevented.
Many

_

‘

'

I am sad that the New Yorker and particularly you. with your
a.record of fine writing, have choSen this topic to attack.. It is easy
easy to damn
"to find the single case which hes not done veil; it
'vith innuendo, error, misquotation, and selective quotation,balance
it is hard
to stay one' a voice when we are ignorant, and to speak with
~

is

V

when we have an urge

to speak.

Some specifics. Free the record given, it is probable that
_.
curs. Parker was a poor choice for this therapy. I anticipate that she
is a person who is critical in her perception of her environment —- in
:.psychological terns, she has a low California F-Scale, makes few errors
c;on figure-ground tests, and is unusually accurate in the perception of
*the visual upright. Such individuals, when they become depressed, do
so gradually, and characterize their depression not in mood or affective
terms, but in body symptoms (often termed hypochondriacal) and are
,

:

'

,

�Page 2

Berton Rousche

September 2h, 197h

generally poor therapeutic risks. The outcome you describe with convulsive therapy is rate, since patients who have her background are
infrequently treated with this therapy. One of the limitations in
getting therapists to have adequate experience with convulsive therapy
is the prevailing social attitude that the therapy has less success
than the psychotherapies, that it is less elegant, and that it repre—
sents (in some minds) a failure of a 'better' therapy. Indeed, one
would guess that the consulting psychiatrist was reluctant to recommend
Regr tfully, had he chosen a form of
this candidate for this therapy.convulsign
there " in which the appli—
the therapy called "unilateral
cation of the electrodes is not to both temple, but to the scalp overlying the non—dominant cerebral hemisphere, the complaints would
surely have been less, for this therapy yields allmet equivalent therapeutic change with decreased effects on memory and recall.
There are also many errors of fact. The historical origins
of convulsive therapy are not usually related to the experiences of
Reil, but rather to the interest aroused in the biological causes of
insanity by the successful treatment of general paresis by fever
therapy by Wagner von Jsuregg. This observation was universally
hailed as a step forward in the treatment of the insane (yon Jsuregg
receiyed the Nobel Prize for medicine for this obserVatioh) and led
many scientists in Europe to-seek other biological rays to relieve the
symptOms of the mentally ill.- Convulsive therapy is usually described
as originating in the lehdrstories of the Hungarian, Ladislas von Meduna,
who Observed that schizophrenia was rare among epileptics and that
;-epilepsy was rune among those with schizophrenia. Seeking_a way to
'rnlieve the plight of severe psynhotics, he tried to simulate epilepsy
hy'intrayenous administrations tirst of camphor, then of pentelenetetrasol
"(Metrszole). The first-patients improved markedly and it was following
his early reports that the Italians, Cerletti and Bini, tried electrical
itinductions of seizures.

»1

,

;

,

Electro—eonvulsive therapy has gone through many'modifications
‘hin the past 38 years. The techniques of administration have improved
(succinylcholine is the latest of the muscle relaxants; the use of a
gﬂ-sedstive, usually Brevital, is not to improve breathing, but to pro-

vide relaxation for the patient before treatment and to-reduce the
excitement which occasionally is seen after a seizure, unilateral
seisures and flurothyl seizures are used in selected cases, etc.).
‘iOur understanding has gone from ideas that the treatment is a punish—
nent for sins, or to frighten the patient to health, through the stage
where the therapy was related to amnesia, to present views uhich ascribe

“K\\\
\

�Berton Roueche

September 2“. l97h

Page 3

to the biochemical hhenges which result from the seizures.
Indeed, the therapy is seen to produce long—lasting biochemical changes
in the central nervous system which are remedial to depressive mood
and psychotic idention, in appropriately selected patients.
improvement

carp about a few specific errors. Insulin come therapy is
not in widespread use. For example, there is no insulin coma therapy
unit in a community hospital in New York. It is far from the inspiretionsl prototype of electroconvulsive therapy since Sahel clearly separ~'
sted insulin come from the convulsive therapies, as did many of his
followers.
To

ECT

cemphor were used

I

first

was not the

earlier.

convulsive therapy - metrezole and

surprised by the quotations from Noyes end Kalb, Hope and
Adams, and Aubrey Lewis for none of these authors have written on the
subject within the past two decades. The quotations from Squires end
Ottosson are appropriate. Ottosson is one of the most experienced
observers of convulsive therapy and it may have served him better to
quote from his more recent studies, and those of his co—VDrkers,
Lsurell and d'Elis, then to use an older study. Squires is a young
am

who hes done only one experiment.
The gho—
"New
Home
from
Medical
Encyclopedia" is probably accurate.’
the
tstion
but one would wonder why you have selected this lsy volume as an

experimental psychologist

authority to quote in the

New

Yorker.

In sun, I em disappointed that the New Yorker, known and read
for its accuracy and fine reporting, sew fit to publish a single case
report, with many errors of feet in discussion therebydoing e dis~
service to the many patients uho‘will undoubtedly read or be given
this article, Ind who will be scored out of their wits if a physician
recommends this therapy. The harm that has been done will never be
known by you, but the many therapists who will find it more difficult
to use this therapy when it is useful will have reason to remember
you, as will the families that will have lost a member by suicide..
—

A

Should you wish to reach other scientists who may find your
report a disservice, I suggest you call Dr. martin Kata, head or the
Clinical Research Branch of the National Institute of Nentel Health,
or such concultants to the NIMH as Dr. Seymour Katy, Harvard Medical

School, Dr. Lather Knlinovsky of the New York Medical College, or
Dr. Charles Shegsss, of Temple University (also this year' s President
of the Society of Biological Psychiatry and the American Psychopatho-

logicsl Association).

‘

�Berton Roueche

Page h

You may

Septuﬂber 2h, 197h

also vish to read some of the more recent volumes
to assist you, I am appending citationa that are

on the subject. and
well known.

Lastly. I would suggest that you spend a week studying a ward
of chronic mentally 111 (in any State mental hospital) and a week visiting laboratorics renoarching the nawnr tharnpiea of tho_mantally ill.
Perhaps than you may be able to write a more balancoaroaponse to your~

self.

‘

Sincercly yours,
Fink, M. D.
Professor of Psychiatry

Max

Mrzed

cc:

Peter F. Fleischmann, President

The New Yorker Magazine,

Inc.

Kalinowsky, L. and Hippius, H. Pharmacological, Cbnvulsive and ether
Sbmatia freatmunts

in Phyahiatry,

N.

Y., Grune and Stratten,
'

1969.

Fink, M., Katy,

8.,

EcGaugh,

Cbnvulaivc Therapy,

Fink.

M.

J.

and Williams

T., Pbyahobiology qf

Whahington; V. H. Winston and Son, 19TH.

Convulsive Therapy, Saminara

in Phyahiatry, 1g; 1972.

/

�</text>
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e

E

i
I

September 16, 197h

F

George Serban,

M.

D.

Kittay Scientific Foundation

hSO
New

Park AVenue
York, N. Y.

10022

Dear Dr. Serban:
Thank you very much for you kind invitation to attend the
presentation meetings of the Kittey Foundation honoring Professors
Cede and Schou. It should indeed be a memorable occasion, and I
regret very much thatFI will be unable to attend as I will be
attending a meeting of the Psychiatric Research Society in St. Louis.

It was kind of you to think of me

the meeting.

and I wish you success in

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

�</text>
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                    <text>.
:v-r 'v-q—vr

"W“vw"

”"mem

m

September 13, 197h

Siva Sankor, Ph.D.

Queens Children’s Hospital

7&amp;903 Commonwealth Boulevard
Bellerose, New York llh26

Dear Dr. Sankar:

I regret the delay in answering your letter of

but it was sent to
yesterday.

my

former University and

August 20,

I only received

it

I thank you for the invitation to contribute to the volume
on "Psychopharmacology in Childhood”. I regret, however, that I have
little original data that I would consider for submission in such a
volume. However, my former associate, Jovan Simeon, of the Missouri

Institute of Psychiatry, has had extensive experience in this field.
I would suggest that you write to him should you wish another
participant in your volume.
My

best regards.
Sincerely yours,
V

Fink, M. D.
Protessor of Psychiatry

Max

MF:ed

4

.

�</text>
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                    <text>SepteMber 13, 197h

William G. Clark, Ph.D., Chief
Veterans Administration Hospital
Psychopharmacology Research Ldboratory
Sepulveda, California 913h3
Dear

Bill:

Enclosed are the references which you requested for the
updating of your volume.
former

I regret the delay, but your letter was sent to
Institution and took some time in getting here.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

Enclosure

'

my

�</text>
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                    <text>-..-..~, nut—4A .1

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SepteMber 18, 197h
a".

,
mm

w-vum—w-rr

Joseph Meites, M. D.
President, Endocrine Society
Department of Physiology and Pharmacology

State University
East Lansing, Michigan h8900
Michigan

Dear Dr. Neites:

I am writing at the suggestion of Dr. Dorothy Krieger.
During the past year, I have become interested in the cerebral
effects of hormones, particularly derived from ACTH. My experience
with hormones is limited to my education in medical school some years
ago, and I inquired of her as to the availability of post~graduate
courses in endocrinology (particularly neuroendocrinology). She
knev of none, but suggested that I write to you first, as a matter
of inquiry, and second, to suggest that there may be others like my—
self interested in such an opportunity.
I

would be

grateful fer your advice.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

cc:

Dorothy Krieger,

M.

D.

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                    <text>September 3.

tor~1n~Chier

;

72015.12.

Street, a.

‘wﬂhimon,

D. C.

197!»

w.

20009

Dcnr?Pr1tz:

It was my undgrstanding that a rcvicw copy was sent
}' Ceuprehcnsive Paychiatry. Eovevur. rather than trsck it down,t9I
enclosing a copy fbr this purpose.
'

‘

,,

Thank you
My

fbr your interest._

best regnrds.
Sincerely yours,
Fink, H. D.
Proteasor of Psychiatry

Mb:

am

�</text>
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                    <text>Septeﬁber 13. 197k

Alfred Freedman,

D.Cheirmen. Department of Psychiatry
New York Medical College
106th Street and Fifth Avenue

New

M.

York, N. Y. 10029

Dear Al:

I

am

Enclosed

is

pleased to acne

a complimentery copy of the EST volume.
to you with gratitude IOr your support

it

interest in this project. I regret the delay in getting it
to you, but I was confident that it had been sent as part of the
original mailing.
and

I have received a request for a

copy from the APA
museum, which I an honoring at this time. If you have any clout
with the APA Hewsletter, perhaps they would recognize the publication of this volume under their new books published, especially
if an appropriate description could he added.
My

thanks.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

HF:ed

Enclosed

�</text>
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                    <text>August 20, 197h

Fritz Freyhan,
2015 B Street,

M.D.
H.W.

Washington, D.C. 20009
Dear

Fritz,

honored and delighted to accept your invitation to
review the volume edited by Itil, Psychotropic Drugs and the Human
EEG". My only caveat is that I may not be able to limit myself to
the contents of the volume, since I know most of the Participants
and their work, and was consulted by Itil in the invitation list.
I do believe I can give the volume a professional review and am
willing to try, with the caveat that if you find the review unsatisfactory you may send it out to another reviewer.

I

am

If

you

feel that I

may

not be able to

do

the volume

reviewers, as Ernst
Justice, you may wish to consider other capable Joe
Tecce—~ these
Cole
Jon
or
Small,
Rodin, Janice Stevens, Joyce
about
issues and
the
knowledgeable
mind
on short notice as
come to

as dedicatld scientists.

Incidentally, have you considered a review of the volume
"Psychobiology of Convulsive Therapy" which I edited with Kety,
McGaugh and Williams ? I do hope you have asked that it be done,
for CP is probably the main Journal that can do the volume Justice.
En another matter, you will receive a call later this week
or the week after from a Dr. Markus Gastpar, a student and faculty
member of the hospital in Basle with Paul Kielhols. He has been in
my

laboratory for a

September.

Thank you

month and wished

for thinking of

to visit washington early in

me. My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>nw-vW'wanvr:«Wm-.wu—vmmrnuvuwmrw

Stanley Yolles,
Max

Fink,

Renovation of

ww—

"a... .u-w-v

M.D.
Yné

New

Space

In preparation for the

in

Tower

for Neurophysiology

of the laboratories to the new
we must anticipate some improvements
in the spale assigned to the EEG laboratories and computer facility.
move

tower in the summer of 1975,
wv‘nn—vlo-

623: Computer

facility:

This will require an additional

electrical cable with special outlets to

'
"—7-“

requirements.

,..

Way-mm...

M.D.

nv"w:

_have

the

S—ton

meet the

1800

IBM

air handling must be arranged tor-- we already
air conditioning unit, but the plumbing and

The

electrical connections will be required. Flooring and cable
assemblies will have to be transferred from thedr present

location to the

new

building.

751: This area is to be divided into laboratory
which
reoms,
will require attention to air handling including
the installation of an air conditioner that We now have in Room
2323; separate electrical lines with special grounding; and
some soundproofing for the laboratory.
I600: Same as 751, except the number of spaces is

‘

greater.
_

V

.

these changes, is should anticipate both the
architectural and financial probllns. If possible, we should
set the steps in motion by asking Planning personnel to estimate 9'
the Jobs and outline the steps necessary; and on this basis, apply
to the Dean’ 8 office (or other appropriate agency) for the
funding and authorization for these modifications.,
To scoomplish

‘X

p

'

A

3

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                    <text>July 31.

19Th

J. Grant, Ph.D.
University of Bridgeport
Connecticut, 06602

Michael

Dear Dr. Grant,

reply.

Your

letter to

Professor Stanley Yolles

was

sent to no for

1. The continued use of psychoactivo substances for‘
Itherapeutic purposes is to be expected, with an increase in use
as physicians find better agents and define therapeutic uses more

clearly.

'

2. Beteuse of the increased education of our community,
for greater controls in rcsearch and limitations on
reSearohers should continue, until an anticipated roaction sets
in, as research in the U.S. is sevorcly curtailed.
;

domandn

memory

.l'

thrusts for paychoactivc drugs seems to be in
enhancers, and compounds with high specificity, as in the

3. The new

studies of peptidos in relieving depression. Another mode: thrust
is in the development of delivery systcms for extended duration
of effects, to provide long-acting therapeutic agents with durations
of woeks to months. This is articularly true for narcotic antagonists.
antipsychotic agents, and tA leptics.
Quotation in whole or in part is not approved.
Sincerely yourc,

Max

Fink,

M.D.

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                    <text>me—n ""erm
r

‘1’;

July 31, l97h
Samuel T. Robertson, III
3267 Queenstown Drive
Mt. Ranier, Maryland 20822
Dear Mr. Robertson,

Division of Biological Psychiatry of this Department is as
that it is relatively easy to describe the work in progress.
The senior faculty consists of myself, Joseph wortis, M.D., and
Harvey Karten, M.D. Other scientists contributing or collaborating with
our work are Bernard Tursky (Political Science), David Krikorian (Botany),
The

yet so new

and Michael Gazsaniga (Psychology),

to

‘
..

name a few.

work is in two directions—~ the measurement of
electrical signals from the scalp of man using digital computer methods
and correlating these changes with dose, type, and duration of action of
psychoactive substances, both therapeutic and those of abuse; and a
clinical study program evaluating the efficacy and safety of new
treatments for menttl illness under grants and contracts with NIMH
and NIDA. Dr. Whrtis is a specialist in developmental psychology
and the editor of Biological Psychiatry. Dr. Karten is a neuroanattmist
Most

of

my

tracing pathways in the brains of pigeons. Mr. Tursky is a psychophysiologist who is measuring bodily functions as predictors a!
attitudes and voting behavior. Prof. Krikorian is interested in the
botany of khat, another of the substances of presumed abuse, used in
East Africa, and which may be the subject of studies of its neurophysiology
and psychological effects. Prof. Gasssniga is known for his studies of
the split brain, and these issues continue to excite him and the students.
My laboratory consists of the usual neurophysiology
Hiinstruments and an IBM 1800 computer for the analyses. We recording
spend much
time with studies in volunteers, and usually have 2~3 fellows in residence.
Should you visit the campus, you may wish to visit the laboratonies. If
so, I suggest you call in advance ($16 hhh 2hh7).

Thank you
‘

for your inquiry.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.

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                    <text>W

July 30, 197h
William P. Blakemore, M.D.
Sterling-Winthrop Research

Rensseleer,

New

York

Institute

Deer Dr. Blekemore,

studies of levo-cyolaaocine were undertaken at the New
York Medical College in 1971*1972. When I left the College in September,
1972 to my present appointment, the records of that-study, with the
date and responsibility for the other ongoing studies in opiate de—
pendence, were transferred to my successor, Richard Reeniek, M.D.
The

I have e study program in progress at the Drug Dependence
Treatment Center at the VAH- Horthport, and we ere exploring the

clinical efficacy of ealtrexone at this time.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 19,
Dr.

J. Zuhin

New

York,

19TH

mY.&amp;uehmmnncmnume
722 What 168th
New

Street

York

Dear Joe:
As a follow—up to our discussion two weeks ago, I wrote
a short editorial for Joe Wbrtis and Biological Phyahiatry. I know
that such opinions are out of fashion now, but expressing them may-

nudge the pendulum slightly 3°° atamcmomy of psychiatric
A

copy

My

of

my

for move it
disorders.

must

if

ever

answer to Klein and Spitzer

we

are to

is enclosed.

regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd
Enclosure

�</text>
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                    <text>July 19,
‘Donald F. Klein,

M.

1971;

D.

LBJ/HMO

Department of Psychiatry
P. 0. Box 38

Glen Oaks
Kev York, N. Y.1100h
Dear Don:

I am indeed grateful fbr your work in setting up the
197h ABBA program, and see no objection to your wish to edit the
volume with Bob. Should there be any other contribution that I
may make, please do not hesitate to call on me;
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

HF:ed
2}
'\

i

go:

ix-

~|

'

A\\-.

\

R.

Spitzef,

3‘

‘

;‘ﬁcc:

J.

Zubin

M.D.

�</text>
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.

vrw—r-

mvn‘Wr-1"\Rn"mmm

mku—m—

mm

197”

Carl Sandman. Ph.D.

Veterans Administration Hospital
1601 Perdido

New

Street

Orleans. Louisiana 701h6

Deer Carl:

enclosing a copy of my letter to Abbe in the be—
lief that you will be able to supply me with the additional information that I need for filing of-theee two studies.

I

am

I am also taking the liberty of enclosing a c.v. of a
assistant, Steven Knhn, who has worked with me for one year.
He has been accepted to graduate studies in psychology at Ohio Stone
rand was one of the candidates that you interyiewed some months ego.
Should you be looking for a young and capable research assistant.
young

I

would recommend him
My

to you.

best regards.
Sincerely yours.
Fink, M. D.
Professor of Psychiatry
Mn:

Merd
Enclosures

.

�</text>
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                    <text>July 10,

197k

urn-my

Dr. P. Borenstein
Ldboratoire dc Paychopharmaeologie NeuroPhyaiologique
Hospital Paychlatrtque do Villojuif

5h, Avenue de

9&amp;800

France

la

Villejuif

‘

Republique
,

Dear Dr. Boronnteih,
by

is the abstract requested. I am not impressed
method to classify or identify drug effects.
Freeman's optimism, I do not think that thesc mothods

Enclosed

the ability at this

Despite Dr.

hava added much
My

ta our understanding of sleep.

hast regards.
Sindorely yours,
Fink. M. D.
Professor of Psychiatry
Mix

Mrzed

Enclosure

�</text>
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                    <text>vmvwwc-

JUlY 9, 19Th

J. Khatin,

Abba

M.

D.

Veterans Administration Hospital
1601 Perdido Street

VP"

New

Orleans, Louisiana 701h6

7v"?!

Dear Abba:
urﬁmv‘r'wff‘

w;
'1'
w-u,

"(VW‘I

mew-r"

filing of the

I have received and will have

no difficulty with the
two protocols evaluating ACTH/NEH h~10 in schizo~

phrenice and retardetee.

toeol:

.

-'-,-v-

WWI-PW

a)

Copy

b)

A

I will need the following for each pro-

of the consent form.

small description (2 to h paragraphs)
of facilities at each hospital.

c) The

official

Columbus

Institute

name of the committees at
State Hospital and Coluﬁbue State

which

our protocol.
d)

will (or have) approved

Since Dr. Sandman is not on 24.13., it would
be most helpful if an M.D. at the Institu~
tion is cooperating in each protect. If
such be aveileble, we should have a short C.V.

I have Just called your office and find that you are
already on holiday and so I will probably see you in Utrecht before you receive this letter. I shall be able to file the necessary
supplement as soon a: the above information is available.
My

beet regards.
Sincerely yours,
Me: Pink,

MF:ed

cc:

M. D.

Professor of Peychietry

C. Sandman
H.

van Rieeen

nt—

�</text>
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                    <text>uv-wrwv-w'

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wrewwlw

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i.

m’w‘r'w‘-v-&lt;

A

u.

~mnwwwlwrwrmmm

Abraham

Sudiloveky,

Clinical Research

Squibb

—

M. D.
CNS Team

Institute for Medical Research

Princeton.

J.

H.

085h0

Deer Abe:

(a,

smzmwv‘r

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r—wn

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—-

:4
a

wj-v—wwrww—mrmmrvwmwvw,mmmuw-m—c

In discussions in Princeton with Dr. B. EtLr, which in~
cidentally I enjoyed very much, reference was mud to studies of
the peptides by scientists at Squibb using material obtained from

I have checked my references. and find a few publice—
1965
with deWied and two others with Upton and Lerner.
tiona
These seem to add
to our information on the central effects
S. Lande.
—-

little

of peptides.

enclosing a report I yrepered for the 197h ECDEU
meetings. I
grateful for any citations to published or
which
may augment this summery and my impressions
unpublished data
of the merit of these atuﬂies.‘ I.em particularly interested in the
studies at Squibb which were cited. and which may be in the public
domain. Would you care-to check with him and with Dr. Clody?

I

em

would be

many

thanks aha

my

best regards.
Sincerely yours,
Mex

Merd

Enclosure

Fink.

M.

D.r‘

Professor of Paychiatry
:‘

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                    <text>June Eh, 197h

William Guy, Ph.D.

The Georgo Wishington

Biometric Laboratory
11501 Huff Court
Konsington, Mhryland

Dear

University
20795

Bill:

packets.
garding

we

I

checked our

My

and did not find any green pediatric

still

waiting to hear from my Dutch colleagues reinterest in getting your advice.

am

their

files

best to

Ron.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

�</text>
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                    <text>June 21, l9Th
Donald B. Cheethem, Jr.
Smith Kline &amp; French Laboratories
1500 Spring Garden Street
Philadelphia, Pennsylvania 19101
Dear Don:

I am very grateful for a copy of the symposium report
on histamine receptor antagonists. While there is little evidence
in the volume on effects on the brain, I believe this type of work

will have special interest for us. I cannot believe that Nature
try to use the some tools in ell parts of the body.

would not

In addition to our continued

my enthusiasm for narcotic
much of my time these past seven

replaced

interest in

EEG, I have
(which
antagonists
occupied

so
years) with an interest in
the natural occurring peptides with central effects. For your
interest, I am enclosing two reports, one on EEG and one on pep—
tides, which may be of interest.
Again my thanks

histamine volume.
My

for your kindness in sending

me

the

best personal regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

�</text>
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                    <text>June 20, 197h
Robert Robinson, M.D.

A.H. Robins Co.

lhOT Cummings Drive

Richmond,

Virginia

Dear Dr. Robinson,

studies of

Enclosed is a draft copy of the initial dose-finding
2277 and haloperidol. Reflected in the extensive
the slow onset of activity of both these compounds

AHR

analyses is
in the doses

initially selected.

have completed the data collection in the
crossover study and the analyses are progressing rapidly. I
have tentatively set the target date for completion of the
statistical analyses as midpJuly and I should have a better
biew of the data then.
We

Again,

my

thanks for your cooperation.

Sincerely yours,

Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>June 17, l97h
John Stern, M. D.
Behavior Research Laboratory
Department of Psychology

Whehington University
1h20 Gretten Street

St. Louis, Missouri

6310h

Dear John:

I thank you for sending me the reprints which have kept
informed of your progress. Lest year I moved from the New York
Medical College to the Health Sciences Center, State university of
New York at Stony Brook, New York. A good friend of yours, Bernard
Tursky, is in the next building. We have had many pleasant dis—
me

cussions.

I look forward to being in St. Louis at the time of the
Neuroscience meetings in October, and perhaps we will have a chance
to discuss the many changes that have occurred in our science and
in Missouri since I left.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed

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                    <text>June 17 ,

Joyce G. Small,

M.

1971:

D.

Lorne D. Carter memorial Hospital
1315 Vest 10th Street
Indianapolis. Indiana h6207
Deer Joyce:
My associates, Peter Irwin and Steven Knhn, ret
with the information we requested. There may be enough for
analyses and we will lohk at them in the next few weeks.

Q14¢/

you for your information on DH—Szh. we
have begun our dose-finding and it is encouraging to know them the

I

want

to thank

clinical effects.
When I was seeking a PI 6208 in the New York area, 1"
celled California and was told that the machine was no longer made
nor eveilahle. I left my name, however, and received a cell on
June 1h from Jim Jordan, beon Electronics, (71h) 556-6500, saying
that he has located a PI 6208. If you are still looking for one,
or if you wish to reserve one in the event funds become available,
you may wish to give him a cell.
compound has

It

was fun

my

best regards.

from Oregon.

being with you, Iver, and our hypomenic

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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                    <text>June 17 ,

Joyce G. Small,

M.

1971:

D.

Lorne D. Carter memorial Hospital
1315 Vest 10th Street
Indianapolis. Indiana h6207
Deer Joyce:
My associates, Peter Irwin and Steven Knhn, ret
with the information we requested. There may be enough for
analyses and we will lohk at them in the next few weeks.

Q14¢/

you for your information on DH—Szh. we
have begun our dose-finding and it is encouraging to know them the

I

want

to thank

clinical effects.
When I was seeking a PI 6208 in the New York area, 1"
celled California and was told that the machine was no longer made
nor eveilahle. I left my name, however, and received a cell on
June 1h from Jim Jordan, beon Electronics, (71h) 556-6500, saying
that he has located a PI 6208. If you are still looking for one,
or if you wish to reserve one in the event funds become available,
you may wish to give him a cell.
compound has

It

was fun

my

best regards.

from Oregon.

being with you, Iver, and our hypomenic

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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                    <text>June 12,

Larry

O.

Rouse,

M.

197%

D.

California State university, Fresno

School of Natural Sciences
Fresno, California 93710
Dear Dr. Rouse:

I have read your interesting suggestions regarding antrainment of alpha activity with hiofeedfsck training and the use
of "reverse tolerance" to LSD for the modification of epileptic
behavior and electrophysiology. The reprints you requested are
enclosed, as are the citations.
While I have no intentioxnof engaging in a long-distance
argument, I would like to question the concept of "reverse toler—
ance". This issue has been raised anecdotelly by street users of
cannabis. we examined the problem and found that tolerance in the
classical sense occurred and that "reverse tolerance" was not a
direct phermscologic but a "set" effect. Are your observations
with LSD sufficiently well controlled to demonstrate physiological
hypersensitivity (i.e., reverse tolerance)? Since heart rate and
pupillary also both change with LSD, perhaps you could use (or
have used?) these objective indices? In our studies of daily ed—
ministrstion of LSD in schizophrenic patients, we found tolerance
development to be rapid, occurring to three daily doses.

I trust these reprints serve your purposes.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max
:

MF:ed

Enclosure

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                    <text>June 11, 197h
/

“K5,"!

{oven Simeon,

M.

D.

Missouri Institute of Psychiatry
shoe Arsenal Street
St. Louis, Missouri 63139
Dear

vaon:

At the ECDEU meetings. you delivered the EEG data cards
and a protocol for the Mellaril Dexedrine, placebo study in dis~

turbed children; with a request that we suggest additional analyses.
To get a better idea as to what has been done, you recommended I
discuss the data with Dr. Hugue.

I did so today. and was told he has completed t~tcst ,
discriminant function, regression, stepwise regression; and d
analyses. He does not have a copy of the report, but recalls
being able to discriminate drug effects. He also recalls corelational analyses using behavioral variable with the EEG.
Before recommending e data analysis, it would be useful
to hone the reports of the previous analyses,tor a sfmple replica- It
tion of analyses would serve little useful purpose. If you lack
the reports, perhaps Turen has copies in his files; or, even they may
still be at MIP.

I will hold further processing until I hear
My

from you.

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

Merd

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                    <text>"-v'

TIN-W
w

v

"g;-

rim-mgr. .

.-

w-“w _: u m; Am-

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--W~/w.'vh-n_::

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June 7,

1973;

lv'umx-Ll‘l

,.-p_--

WW.7_»V.

r—rvrv.

:,
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w-x.

l'ﬁ’vmcivuryrw"

Mr. William Resell
V. H. Winston &amp; Sons, Inc.
1511 K Street, N. W.
Whehington, D. C. 20005

Dear Mr. Begcll:

I want to thank you for the ten voluaes. Before I could use
I
these, received two packages from Wileyb'twenty volumes each.
Rather then return them, I have accepted and paid for the two ship~
meats.

What do you wish me

to

do with

the ten

volumes you sent me?

Sincerely yours,

Max

M. D.

‘

MD:ed

P. S.

Fink,

Department of Psychiatry

exhibitors at the Society of Biological Psychiatry,
British Neuro—
no meation
logical Association were busy. Unfortunately,
books
were
(Holstead)
Volume!
Wiley
ECT
Other
of the
they
(Reitan)
suggesting
in
some
still press volume. I am enclosing
exhibited,
a
this
ignoring
are selectively
information.
for
Academia
your
listing
copy of the

The

American Neurological Association, and

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                    <text>June 7, 197h

Richard Resnick, M. D.
New York Medical College
Department of Psychiatry
5

East 102nd Street

Rev York, N. Y.

10029

Dear Dick:

Reading reports of the work of Tennsnt on

Darvon—N

brought to my attention that the principal toxic effect of the
compound may be in its seizure inducing propensity. Nowhere did
I find evidence of CNS studios.
Should you wish or be able to assess Darvon-N for its
withdrawal use, examination of the EEG records would provide an
objective (and obvious) answer to the question.
A

n

I

a

who».

«.1

would be glad

WW

My

nu-

a.

to cooperate in such a study.

best regarts.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

�</text>
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                  <elementText elementTextId="103893">
                    <text>June 6, 197k

Biesen,

Hank van

M.D.

Scientific Devetopnent

H.V. Orianon

Group

Oss, Holland
Dear Henk,

Hurray

I have received and read the protocol from
and believe that he has expanded his

Jarvik,

interest in memory mechanisms to encompass the
peptides. The protocol is apparently a part of a
large application for research support, and I an
sure that making 01—63 available should add to
the information on the central effects of the
peptides. His review of the literature brought out
additional references which I will get.
Enclosed is a set of reprints from my
earlier work on the effects of drugs (chlorpronasine
and inipranine) on various perceptual and attitudinal
tasks. For comparison, I an also including the results
of induced convulsions (ECT) on these tasks; and when
I was deciding on the ones to select, I found one
or two additional references that bear on our mutual

problems.

is sending Hrs. Rosselson, his
laboratory next week. Thinking
of her visit, I recalled some discussions regarding
T. van LierOp—- is there some merit in having his
2
Leo Lange

technician, to

my

visit

It is already

June;

my

staff are thinking

about the summer holidays.;ny daughter Rachel

is

graduating high school at the end of the month and
we face her leaving for the university soon. The
weather has been fine and we have had some good
week-ends in our country home-- not many fish, but
plenty of repair work.
See you next month in 083 and/or Utrecht. My
best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>V“, m,,.-_.._lV....V.....‘..w-,.-A

‘pmwwp_m_~._~

.

waqw

,.

,

mar

November 29, l97h

Mrs. Eva

J.

LIJ—HMC
New Hyde

Park,

Meyer

Research Grants Manager
New

York

Dear Mrs. Meyer,

I enjoyed the opportunity to review the two proposals
submitted by Dr. Struve. The one on agorophobia and mitten patterns
seems wotthy of support, although I believe the estimate of time
and cost is probably underestimated by at least 50%.
I could not Judge the review proposal since there is
data missing which would assist me in my determination of likelihood
of success and worthiness of support. Should the proposal be
submitted again (if unfunded), I would be willing to review again.

to the suggestion that one reviewer believes the Bumitten
clinical significance, that is the question which Dr.
Struve is attempting to answer. At present, it is probable that
few observers can elicit the B-mitten and that the pattern is
inadequately studied. Precisely for this reason, Dr. Struve should
be encouraged to continue his explorations and if he finds or
comes to understand the significance of the observation, bb teach
not to

As

have

us, so that

we

can apply the data in our

clinical

work.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry
Max

�</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="86789">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="93350">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="99911">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
