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                    <text>,m»

29 September 1973

Jiri

Roubicek
Experimental Therapeutics Department
Sanloz Ltd.
Dr.

Basie, Switzerland
Dear

Jiri,

It was a great pleasure to be able to attend so many of the
meetings in Marseille with you, particularly the many discussions which
fOllowid the presentations in our common session. As a chairman, I
very much appreciated not only the content and the spirit of your
remarks, but your willingness to lead the discussion. I found the
meetings most helpful and interesting, and I look forward to continue
the discussions in your laboratories.
I received the enclosed letter from Professor Kielholz. I
at the GIMP committee meetings in Beerse before Marseille, and
in exchanging pleasantries indicated that I would be visiting Basle
in October. I am also enclosing my reply-- trusting that you.can make

met him

arrangements which are diplomatic and acceptable to you.

family has discussed the forthcoming trip often. Neither
free to come with me, but Linda, my youngest
me. Because I wanted to allow her some freecome
with
will
daughter
dom, I am also bringing along my nephew, and so I will have two youngsters with me. I would be grateful if you would arrange fOr two rooms
for the two nights. In checking my travel arrangements, I am scheduled
to leave for Amsterdam Friday morning at 10:30.
My

Martha nor Rachel are

regards.

I look forward to visiting with

you and Marcia.

My

best

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

amen v

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                    <text>7—w-

-

“mu-WW.“

September 29, 1973

x—

w
,

v-w-qnw-w';

«v,

Prof. Dr. P. Kielhola
Psychiatrische Uhiversitatsklinik
Basel, Switzerland
Dear Prof. Kielhols,

~‘w~r.'mm-wr

""‘v-rn

,“.1

grateful for your kind invitation to come to your clinic
during my {Orthcoming trip to Basle. I would be pleased to visit and
to discuss the ongoing research into the CNS effects of psychoactive
drugs.
I

am

I an visiting Beale as a guest of Dr. Jiri Roubicek, and old
friend and co-vorker. I do not have a schedule for my visit, other than
I plan to arrive in Beale from Zurich on Wednesday morning, October 2h;
and to leave for Amsterdam on Friday morning on the same flight which

you have scheduled

at 10:30.

would be grateful if you could call Dr. Roubicek. I am
confident that any arrangements that are suitable to both of you will

I

be acceptable to me.

I look furvard to seeing

personal regards.

you

later this

month.

My

best

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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Stash Press
638 Pleasant Street

Beloit, Wisconsin

53511

Gentlemen:

Kindly send us one copy of the volume:
"Msnsgement of Adolescent Drug Unee". Enclosed

is our check for $5.00.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Mex

�</text>
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                    <text>September 20,1973

wnlter Essynn Ph.D., M.D.
Deportment of Psychology
Queens College of CUﬂY
Flushing, ﬂew York 11367
Dear Walt,

I am pleased to accept tho appointment as consulting
editor for the series, Recent Developments in PsychapharmaooZagy.
You ask for suggestions for the initial volume, and
while I do not yet know the range of topics already committed. I
would suggest you consider a chapter on tne application of

quantitative EEG to the classification, identification and
dose—response measurement of new and presumed psychoactive drugs.
This method has had some interesting applications recently, and
deserves

more

exposure.

It the idea is

I coulo send

or some inteoost,

you a

copy of recent publications and an outline of a possible contribution.

Again,

my

thanks for the

invitation.
Sincerely yours,
I

Max

V

Fink,M.D.

Professor of Psychiatry

�</text>
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                    <text>Septeabar 20, 1973
Dear Turan,

I received capiea of your letters of invitation to
and to Dr. Horrnana. inviting than ta participate
Polvan
Profossor
ACNP
session on trannnultural a:pactn- studios of new drugs
in the
tho
outside
v.3.
'

care to inwiea Hank van Eiazan of Organon
to present thair study program 1 I hive invited him to attend the
A53? as my guest and perhaps he could dascribe the 63*94 or the
61‘63 8 tax-ea
Would you
o

my

best regards.
Sincerely yours,

Mix

Fink,

M.D.

�</text>
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                    <text>Septembar 20, 1973

Ralph

W.

Ridhtor.

M.D.

Harlem Hospital Cantor
135 Stront &amp; Lonox Avonua
Haw York City 10037
Dear Ralph.

to have an opportunity to ravine the
chaptor on narcotio antagonist: for your volume, as there havo been
some additional data. particularly with regard to nnltroxono, which

I

was plunged

should have~been included.

'

'

Enclosod 18.1 rovidad draft of the roport for your
will be accopcdble.
consideration. I trust

it

my

boat regards.
Sincerely yours.
4L£f

.vW
Max Pink, 24.13.
Professor of Psychiatry
u. v

�</text>
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              <elementText elementTextId="57322">
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                  <elementText elementTextId="106760">
                    <text>September 14, 1973
Warner K. Herrmann, M.D.

Scharing

AG

Poatfach 65 03
1 Berlin 65

,

ll

Dear Dr. Herrmann.

for sending the interesting article on
tha origin of nattcr. I have sent it on to my son's: Stanford Univerulty
and he thould write to you dircctly.
Thank you very much

t:

I would be pleased to mac: with you
your convenience. I
60 not know when you at. returning to tha States. but should.yeu travel

via

York. please stop for a day. I shall be in my laboratory
October 24 whoa I am planning tnother trip to Europa. and

Naw

until
will bu

away

for three utaks.

Ho have had an attlvn sauna: at the beach. with mnny visitors
sud many new experiencns for my family. It has been a good experience.
Dr. Itll and his family span: a week.w1th us and that was a moat anjaydble

time.

.

.

Please cone and

visit

noon.

Sinceraly yours.

Fink, M.B.
Professor of Psychiatry

Max

ut/

�</text>
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                    <text>September 13, 1973
George O’Brien, M.D., Ph.D.
Departmant of Clinical Research
Abbott Labcratortee
North Chicago, Illinois 60064
Dear George,

It was a pleasure to speak with you yesterday, ana I am
interested in the dartvativea of cannabis. I look forward to maeting
with you an your return from Paris.
Enclosed is a copy of the guidelines for the evaluation
of anti—epileptic drugs. This was distributed in the registration

packet to

all

the registrants at tha Intarnational

in Haraeille early this
my

month.

EEG

wanting:

best regards.
Sincerely yours,

2'“ Pink.

HOD.

Professor of Psychiatry

�</text>
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                    <text>Ausﬁﬂt 23. 1973

am: a; madman.

RIIIIth

II.

eon-u1tanc.=saon12
Inn-mum»; me; 20:00

DIIr Dr; Mindiluon,

I

w1th IIIh inacrcat and Uith
IIII that “353; stratus:VIII
doeunantad
AI

to

you
III your IIIII1IIII II I
rIpoII.
requIIIId. I thI rIId thI SectiIn 111 c IIfoIlly. and III IIIII11II
If thI IIIIIIII 1I EhI tIporc.
command

you

IIII

III IIdI If IIIiII of III vIIiIuI
tbs Iffccta 1n thI

drucI usually IbuIId 11II 1n
UI1I5 the nIchIII of

IontrIl IIIVIII IyIIII.
IlIctzIphyI1I1Isy, IIIIIIIII IIVIIIIIIII hII been Ionitarld for IIIy
It thI drugs at IbuII pItIntinl. quld IIphII1II the 3tIIeIr
IIIII1II11II by thI Ilaccrovhya1ologinta Ind thI1r nIthoII I1ﬁh the
IIIIIIIII1I1I III IhI1: IIehIdI II ebb IBIIy It the £I110I1ng IIIII1III:

I

'

w;

“IhI

rItI
I1nor trIIqu1111xItI;

If dIIIleIIIc

of Iolnranee :9 1h. IIdIt1VII Ind

".. thI intIrIctinn If thIII IIIIIIIII with agent: known to
contral nIuthIIIrI II1III1VI1y, II attempt I I11r1£1catton
d1f£IrIIt
IltIr
If thI IIIIIhIIIrIl IhIagII that IIIIanny IIlIrIIIe dIvIlopnInt; and.
'

'

"
IIVIlopIInt It 'IntagoniitI’ ,
“the
Ind
thI
bnrb1IIIItII.
Ilaobcl
‘

,

III: IpIIifically for

A IIIIId
III; of 1IIIII13II1II 1d thI IIId to IIVI1II drugu
IIh1¢h IltIr hrI1n tunetiun for IxtInIId pcr1odn. This dIvIIIIIIIt hII
,f Ilzandy bIII IIIIIpl1IhId for EhI Int1pIthot1I drugs; III boan jo1IId

"Ju

If I laaszIcina II1I16 Intngon1lt; and should be
thI dIvulopIInI of I Ions III1I; IIIIId1IIIp1II (tI
IlIIhol Inbatituta).

1n ehI dcvhlopIInt

Canburlﬁcd for

bI IIId

II II

IIIItt IInI1III,

but III. III IIII to I1Ibctaca, ehI IIId
for I morn int-III effort It III ddvnlIyIIIc of II Ilcdhol IItIson1It1n pIrc to aid II: undIrItInd1n3 If alcoholinu III IIIIIII deInIInII
thIIulh III tIIt1n¢ It ctIItIIn: IIdIlI I1I11Ir to ehIII undo: Ituéy
1n Ip1I1d IIIIIIIIII II1I¢ aha IIII1I1I IIrIIt1c IIIIsIn1ItI.,
'

ThI

�,~--;.;‘W-

‘W

—-v—.

,

‘f'v'1ﬁ'v.

irm’r’aw‘.

J‘&amp;

H.

MCJJO‘.

31D.

«nut-oou-nib‘umt 22,

1973 oncdovtbaonosétqpﬂ 2.

.
11-:

wwwwxmmrv'"

w
-._

nm

,
my

worry-my

Stratggzlutntienn, but doc: an: anyhaatsa suffieieuuly.
the psycholosic eouponane; of toltrnnnn and dcptndancn dcvtlopncnt. I
ht?! bacon. tart-sand that tho davulnpmant at talgranac no tha'upiatea
ptaeiods at varying raton for dittortnt anpnatn at bdhtvior- being unit
lonaqr
rapid for tho na1f~rupnrt ayntamn at wand and attitude; slightly and
for alaccraphystalogte maasuxcl 5! the ass :94 task purfornaace;
tuck informatiau 1‘
Ian‘s: still far the nutcnoaic CH8 offsets; Whilcstadium
of than.
ariildblc ta: ta. barbituxttnt and the apintas,
and
s'phecauiaal
pattnrnn with the bonsodiauapinaa. cananbil. ulenhol,
warrantn'furzhar study. partiaularly Itnca Eh: methods a! nonsurensnt
The

of bdhaviar.zcns yhyaiolagy. and tank yarfarnanac hava improved aonr
aidorably. The goal at that. atuéicg could bu to deiina tn. pattern
a! telenanad development, rolutionn to dapandanao. and tha variations
among Iﬂbjlﬁtl. :9 salad: uh: tayortsnt quastionn of the charaacartttién
of chi ‘daptnﬁence~liabil£ patron.

aaall point with regard to caution III 6. Tha pauitian
with regard to ¢anndb1u is strainnd and unaonvincing. I unndcr shy eh.
cannsbia u3¢, vhcn
repert pays no little attention tn the uvidcues that
Tha
cvidanne tron ths
Inﬂ
urn.
_ptolana§d. inducas tolatanat in animals
inhaled
by Janaiinns
Nina contract ﬁtudicu of high dons: at eannabts
One

and Grunts

Arkans, subject: ranpond to 150 we ran»
new York valuntnexs snaking 10*15 mg.)

is impressive (in

acltuua equivalent lika

for tha opporéunity tn rand Ind raspond no this
doeunhnta'Ijrograt that I rncaivad 1: tea late to nae: the date an:
in thd 10tt¢r- but ptrhaps thee. thought: any ya: prov: helpful.

I thank

my

you

"

best rcsardn.
sincerely years.

I!“ “ah,

MIDI-

Ytafesucr of riydhi‘tty

.y—t-s-w‘rvr;

7
‘

~

:vx-n-wu

4-4 WWAA‘I—r-t'lrw-‘v'rrv—

�</text>
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                    <text>at.
V.

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at 11:: of participants, and the eonﬁorooot connotaood ockmlodmott. for inclusion in tho amino on tho Pr"
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to tho pinata: of this vol“.
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                    <text>1-.

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mum-n. »_v-.v.mzuv--

is
W
'1“ MI. 3"
n13.1314-

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":5

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August 22. 1973

K1113. Hons

hospital

YO“

Durban.
I hm sosd tho outliuo of tho smootod pron-so for tho
sad not for so oxcollont formation.
sposkoto. you hm thou-mod tho
s
stroy

.

sud wish to mootulsto you
ms hosting, such
£o'tuidsblo
of

ly dmlopiua
lootwot sad as to

Roch

costs up with

«nothing of oquolly tins qus‘lity.

to spooitios. 8.1m mom is prosontin: on tho
dismount to: Labor-sky sud Prod: should ho Lovitt. I would
to mass his “potion“ so ho dooos
and»: ho
soproprists, olthough ho could to on woolloot oltsmts choimu for tho
As

second dsy. tho
concur thot Boy

mom

first action.

You osy out to couoidst moths Shogsos so o discussont of tho
hoh-stiot thotsuy nation 1! Joins Frank is not sscoudsd. masons hos so
sctivs iotot‘sot in this thstspy sud hos misusd tho dsto wtonsiuoly.
'

'

sddooss should
tho Koch sword

tho troditiou of tho

Foch «std sud tho Possidsotisl
sud hsvius one ooch dsy is sstisfsctory. with
also no tho
sword, sud this osy «quits o too oars oinutso.

to stintsiuod,

will

V

rum

For moons of history, it would ho us'oful if so could inoludo
Exits Payton. ”shops so s couchsirosu o! coo of tho sossions.

I

would oucoursxo you

to {cmlsto this prom-so so

occsptsd, soot-sins tho othot woos oi tho Council moo. sud you writs to
tho invitod portioipsnts tor so abstract. Should thoso ho svsilshlo by was
sod of
or only Octobor. to soy yo: ho shlo to host tho usual
rush for tho dosdlino of tho Journal.

not“:

My

thanks for on

woollsnt job.

diatom, you-rs.
Koo

to.

30 Colo
R

Spits“

Fink.

24.1).

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                    <text>wv-W “Wu—n—

a

'uuvanwi
“7",”

_

Angus: 22. 1973

“mt:

SW11}... M.”Acttns Dirnctor
Div. Haurophnrlncological'Dru; Produces
lurcuu of Ernst. 13A
Ractvtllu. naryland 20852
'

'

D..r ”to

3W1...

'

Ra: IRE

9691

In rcupons- to your 1act¢r of July 2. 1's: nacloaiug a
ruply prtparod by aha liberatoty scientiucn at H.V. Orssnoa aha
havn boon rcsponnibld for ch. basic studio. at the eoapound,
GB~94 (Hiunnqria). I'baliuva that: taply 13 responsivu, and
ask that this b. and: a.nattix gt record for this projcec.
Thain you for your eoopcrac1cn.

Sincgttly yearn,

m: Fink. my.
Professor cf Psychiatry
.

Encc

3

Lt!

EVE

8*14“73_

�</text>
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                    <text>~‘m'ﬂ'mwp-yu «pr-mung,

‘

August 22. 1973

J. Bruinvuls. 2h.D.

'

Asainttnt Editcr

Eurcvaan Jouruhl of'Ehnrnnaology
Utracht. Netherlands
Dear Dr. Bruinvola.

rung:

.

I.h¢w¢ ro-tnad tbs manuscript by Faingeld and Entry with
plansura, and bellow: that it should be published.-Th¢y have nnlwnrcd
almost all at :hg erieicigna thut I‘rﬁ prcscntﬁd by ﬂycalf and the
other raviawur. except the an. of thu spectral ratio. This as. is
eontrovoruial. but that: prgocntation of chn data is uuah that the
ratio probably rcfldcts the ngeurnl axptriunce as wall as any echo:
Innings.
.

_

I nn-rcturning tht manuscript. I rcgrct the daisy in

nnnwnrins, but.thil was occasiouod in part by the article having
bean scat to my torn-r 14420:: in ﬂaw York City, For your records.
91.... not. chn.addtpsa Ibavn for tater. aaununieationl.
‘33 best rogsrda to Dr. dc Visa.

Slncaroly ycurs.

Max.ttnk,

M.D.

trofnssor of Psychiatry

�</text>
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                    <text>my

29. 1973

EEGJenr-nel

Eleevier‘

halterden
Gentienenej
‘

1 have moved my

laboratory to

reqeeetthee the subscription represented
be cexit1n‘ued, but addressed to:
'

a new locat1on,

by the attached

I
lebel
and

.

_

_

‘Dr. Max Fink
HSGuDepertment of Psychiatry
sun! at Stony Brook
.Stony Brook. New Yetk 11790 U. 8.A.

'lhenk you.
’

'

‘-

'
..

-

b
.
&gt;

,

.

.gtmereiyfhun,

nu mg;

VPeoteEsqr

m
of Psychiatry
,

.

�</text>
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              <elementText elementTextId="57402">
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                    <text>W. H, rmw»"‘:I—W“

My 19.

1973

Bhertbeth Mendel
Copy Editor

Me

‘

AMA

Illinois

Chinese,

Deer Me. Handel.

‘holoeod is our edited tmeoripo of the lumethedyl
We ere pleased to accept most or the.
chenaee.
end hove mode e row edditiona (mined in red).
‘

.

report,

Baa-67141: .

'

'

'

issue is of significance. We heme need lama
elohe-aoetylmthedol hydroohlorido in this otudy. I note that in
ember or places, you have
to 'leemethedyl
metete'. It the ‘ecetete' is meant an a. generic port of the
then the empriate tom Would be ”'lovomothod‘yl mote“ ‘hydroehloride' .
If, so I Inspect. the 'aceteto' refers to tho eelt, then the appropriate
ie 'levouethedyl Ivdroohloride' . I have enema the lotto:- in
editing the typeoorip’t.
'

One

edited-1W1

m,

in

.

In support. of this View, I would like to Intuit lone
deoe ream-ding our compound; es veil a". e copy or our 1973 eu'boieeion.
M: thet. time the editors also mended the
to 'levomohedyl
metote' . We were not alert enough to catchtmecript
After goblioetion.
this.
we noted that the editors bod added two names to the end or the
indicating the levonethedyl eoetete 1e Methefrommet-hedode. In ertiolo.
oheokipg
11th the mocha-er. Merck I found that neither
end‘
is
.
theirs;
one
i a checking with the
indie» . I found mo neither

Mention
hove my releteon to levouethedyl hydrochloride.
mm“. nor Mhetroue
-

8w

I eleo note thet in en eerlier ertiole by Jetre 5
21648, pplBOBff) than: the confusion of tens ie eleo unresolved.
Perhepe . the g; form
be celled 'uthedyl eeetete' while the l. for:
celled levonethedyl. 'l‘hie m eteted
in elletter to no by mother,
(JANA:

JANA

copy

egeio. end

m

editor. Mn. Veiee on hornet-y 29. 1972.

for the opportunity to reed the tneeoript
I look torwerd to its publioetion.
Then): you

'

-

sincerely
Me:

me,

rink. 1m.

Profeeeor or Peyohietry

.

�</text>
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                <text>Correspondence to: Gardner, Elmer</text>
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                <text>1973 </text>
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              <elementText elementTextId="57408">
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            <elementTextContainer>
              <elementText elementTextId="57412">
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              <elementText elementTextId="57413">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <name>Format</name>
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              <elementText elementTextId="86504">
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          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="93065">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="99626">
                <text/>
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                  <elementText elementTextId="106765">
                    <text>Jul: 13.

1973

33!:

8569

Elmer Gardner; M.D.

Diviaion or Raurophurnnoology

FDA

_Bo¢kr£11c. Mhrylund 20852
*

13D

Dear Dr. Gardner,

I wish to amend the IHD for the study or 01-63 hr an.
unclestd protocol submitted by'Dr. ﬁbbn Kiltin of thn VIK~ New Orltlnﬂ.
The Gusset: and procedures of this protocol are consistent vith our
ydor submissions; the study extending the examinaticn of OI~63 in
new population.

:

Apprbpriate safeguaras for the protection of
subjects are included in the protocol.
,

humnn

Sincerely yourl.

‘

h F”. of
Profousor

“the.

PlguhiuSry

�</text>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
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        </elementSet>
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    <itemType itemTypeId="1">
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                <text>Correspondence to: Stefanis, Costas</text>
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                    <text>July 17.

1973

Costa Stefunil, 14.1).
of Pays-hum
"‘
mitten Kospital

Went

Athena, Graeme
Dear

Cantu,

halo-ad are three chock: following your request:
l1366 0.3. for salaries
$ 11,200.00
(1390)
#36? 0.8. Ianoct feet
~

,

11368

0.8.

mph”
oops-mutton
I

(600)
to 6/30

1,990.00
2,500.00

Lino: directly the sun at
81.690. representing the salary dune him; and sent Costco Kira:
“minimum his animating um! laboratory expenses to
$1.636.
ISO 73.
.

have ulna paid Dr.

mm

mm
unspent to Donahu- 31, 1973. You will note ms I
ruin
have What some of your requests to arbitrary catngorios, to
as can of theandcontrast allocations. Plan new that m categoricall the
ﬂuiblo.
any cam” (mm
m
m availabl- in to
which an
the mount:
tan]. and Marianna»m
I m melanin; an

“1,380

whiz):

indium: that

”maid

wanted) .

m.mm1ammwd.nommtmmunw
m1 three am km in stony Brook; ha ha
12:1!“ka
“mist“ to
rudmduu tho autumn mm, m is nova-aiming

mm
Warnsm.mwnmmmnthnandofthismk.

mum. I have mum 300
mm.
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Linton umwmzmuscau;
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”not.
Ivtutry
to bring
the and at August.

an.
mm. but cannot obtain a 1.9.1 use” Home
“port ecu-tiring“ ﬂat I
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to th- publication prob)...

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“emu.

�</text>
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                    <text>My 16.
Janna
VA

Klett,

1973

Ph.D.

Eerry Point, Maryland
Dan: Jun,

It

van a pleasure to vnwk with you and Sun in Dcnvnr.
study sauna well~1n~hand. and the investlgntorl lean enthusiastin and cooperative.
The

is a reprint of the study of laboratnry tests
associates and I carried out in Missouri as part Of tho
ECDEU program. It suggests that concurrent inborntory
tests in
taxable controls provide the prlncipnl comparison for evaluating
whcthnr a new drug alters laboratory tests: the rcnaons include
variations in laboratory standards, tnahnicinns, tin: of ynur
Encleaed

which my

Ima

season, etc.

Holden went on to dcacrfbe significant changtl in
tutti. when comptrod to concurrnnt controls. with
receiving thioridnsinn and/or chlordianapoxido (Chadd. Pbyoh.

lnbarumory

pittants
J. 14:299~301. 1959); and in unothor study. in patient:
rnceiving hulapnridol (Biol. Pnyeh.3: 173~182). (I helluva there
.3 also a more rocont rcport. bun I do not has.
it in.uy lib.)
I would luggnst, thnrctorc. that tbs boat control will
be concurrenﬁ Iluplal in thn patient: ronclving mathndonn, ﬁnd nhnt
Anson.

~nll canpnrisonn be botvuon the sroupn, rcthdr than nautnnt taxﬁbook
or proncntdblinhod lnborntory standards.
One

indiaatod than

other point: the printout of the urinounnnlynctn. nrino. If the tent

no subject hnd conning in
was not coup. in would b. butter to mark

rnnhcr than

this :- "E.D." or ”—-".

0.0-- rooqrvina thls notation for
I look fnrvnrd to grouting

n ronl 'nngntivu’.

you ’nmunsat'

in August.

Sinoarnly yours.
Fink. M.n.
Professor at Paynhintry

Mix

�</text>
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                    <text>My 9.1973
ﬂeece Pierce, NJ).
Ortho Reeeereh

12mm.
Deer

New

mam“

Jereey 08689

We.
writ» that

or Beptenber.

of Dr.
um
women”

Enclosed is 0. copy of the emicmlm
he bee received the edditionel

mm.
ebm 8063 end the: the and: in meaning well.
Xe

He

I had intended to View him during the eecond week
writes. hover», thet he V111 be in Bpein et ﬂat

tine-airwavetocmgewumm, ”melee-poem trip.
We

heve begun work on the protocol for en

eleohoneaetndy.endumu1heveeuethingtam,1v1n
eeadttontoyon.

what ram.
sincerely y
Hex

we ,

Pink. NJ).

�</text>
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                    <text>July 9.
Dr. Joan.

1973

Villiona

Dopnrtaant of Political Satanic
BUN! ot Stony Brook
Door Dr.

Williams.

wo undorstond that the Department
ho: a sorter. which
in ovnildblo for the use or other Deportnonta
from tins to tins. Vb
occasionally need the latter for 1~2 hour: to rogrouy data from
ongoing otudioo.

Mr. Ira Snaipor is responsible for the work
under
my’dirootion, and I would be grateful {Or any nouiutonoo
or
potato-ion
you may he able to give him. Should it to possible to make
a key available
for his use, V. will oooopt tho rooponnibtlity.
Mhny

thonka.
Sincerely yours.
“jZé;Lk{;2;&amp;dL

Fink. M.D.
Professor of Psychiatry
Mo:

�</text>
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                    <text>73SBn848SB
28 Decombcr 1973

Craig Burroll, M.D.
Vice President-~Roooarch

Sandoo Pharmaceuticals
Hanover, New Jersey 07936

Dear Craig:

Sitting in Loo'e choir loot week. he told no of the many
interesting things thet you seem to be doing. It must be a far
cry from clinical drug evaluations. Yesterday, in reading a
list of new publications. I found e citation for The NonrModicel
Use of Drogg; Contoqggrory Intervention Isoucg. The citation

dooe not have an address for the publisher, and I would be grote~
ful if you could have your secretary send on tho publisher's eddrooo end the price so that we can obtain e copy for our librery.

In October I had tho opportunity to vieit Sendoz in Basel
and presented a colloquium on my favorite eubjoct, the CNS of~
facts of psychoactive drugs. I was delighted to find their labo~

tatorios fully equipped to carry out computer processing of

proelion.
My

mwa-VWW'WTW25

regards and boot wishes for a healthy 1974,
Sincerely yours,
Max

Fink,

M.D.

Profoueor of Psychiatry

-

2x".'1w.11

EEGe.

Both Dr. Roubicok and his co~wotkor, Ht. Metejek, have done a
uplandid job in programming. I hope that those mothodo for predicting psychoactive drug effocte will find coco practical ox~

MF/cie

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                    <text>73AP-850AP

28 December 1973

Donald F. Klein, M.D.

Director (Evaluation)

Department of Paychintry

Hillside Hospital
P. O. Box 38

Glen Coke, New York 11004

Dear Donald:
Your judgment about Lehman Corporation stock is correct.
price discount: the net asset value by at least
202, and 1t is impractical to sell the shares at this time.

The market
When

the discussion started in the spring 1:

been on appropriate time to make some changes.
present, I believe we ought to do nothing.
my

best regards

And

may have
For the

best wishes for a healthy
Sincerely yours,
Max

MF/cis

Fink.

M.D.

1974,

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                    <text>7383*84ﬁ83
27 Docaibor 1973

60““

“muky

g,

H! .D 0

Boston Univoroity
80

East Concord Seton:

Boston, Mhooachuoott- 02215

Boar Conan:

I

writing to tooonnond H111 Coxolyo Poinior, who in
intorostod in continuing ho: oduoatiou in Boston and may call
you for advioo no to a position an o roloorch nooiocaot. 8h:
sroduotod Colby Callus. with «aeolian: groans in Juno, 1972,
on

and has booo‘with no
pat-d in tho work of

that. post

13 months.

Sho has oarcioi—

this luboratory folly. inoluding recordw

precaution of REG using the IEM 1800. statistical
onalyooo and bohtviorol «valuation: during human oxporinontow—
all of that. in halo voluotooto.

ins of

EEG,

She is on ottroctivo and char-ins girl with onthuoioln
unmatchod by any of tho only young pooplo who have
workod for no. 8h. in rolioblo and dopoodnhlo, and I racon—
oaod ho: highly.

that is

Should oh: call, I would ho stototul for any advico you
xiv. hot for opunioso {but any utiliso hor tnlonto or
hroodon ho: oxporionco. I would also ho grotoful if you would

may

bring thin
My

1974,

lotto: to Allan

Miroky'o actuation no "I11.

boot poroonal contra: and boot withoo for a hoalthy
Sioooroly yours.
Mn:

Pink,

M.D.

Profoooor of Poyohiotry

uF/oio

�</text>
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-=—r-.yi..-.r

W—w-

-4

7333~86788
27 Daaambc: 1973

Rabat Mbyur. H.D.
Dcparcnnnt of Psyahinery
Harvard Modical Schoal
Hebtan Hoapital
115

Hill Surge:

Bolnount. Misaaahulcttu 02178

bunt Hagar:

I an writing to raaalncud H11: Cnxolyn Poinicr. aha 1;
internstod 1n aontiunins ht: odueation in Boston ﬁnd any 5:11
you for :dvicc an to a position as h r'seareh an:1¢:ant.. 8h.
graduatad Colby €011.30 with cancllunt stadua in Jana. 1972.
and has bonn with an than. punt-18 nontha. She ha: particin
patad 1n eh: wnrk of this laborgtory fully, including rocord«
in; at Inc. proeatainx of 880 using aha 13H 1300. lentiutical

analyses and bchavtornl «vgluatioas during hunnn caparincntn-~
all of chnuu 1n uni. voluntcctt.

is an acera¢etvu and charming 31:1 with enthuatasn
unmatchud by say of aha win: young poopln who havn
worknd to: an. Ska in rnltabla and dcpondnbln, and I racon8h:

tht: is

nlad but highly.
Should aha

racy

enll, I

would

b: grntatul for any ndviuu you
may utiliua hat talent: or

31v. ha: fat opcninsl that

brandcn hut unpariaaco.
1976,

my

bus: par-anal rugnrds and bolt vinhca for a hoalthy

Sinatraly yours,
Ha: Fink, H.D.

Prefualor of Payahintry

Erlets

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                    <text>7383~846SB

27 December 1973

Joseph Thane, H.D.
Research Division

Boocgp

State Hoepitol
Street

S91 Horton

Bolton, Massachuoette 02126
Dear Joe:

I on writing to recommend Mien Carolyn Poinier, who is
interested in continuing her education in Boston
end any oall
you for advice as to a position en a research eeeiotent. 8h.
gredueted Colby College with excellent grades
June. 1972,
and he. boon with me these pee: 18 months. Sheinhas
pated in the work of this laboretoty folly, includingparticirecord~
in; of BIG. proceooins of EEG vain; the Inn 1800, otatiotioel
analyse: and beheviotel oveluetione luring human experimentsall of those in male volunteers.
-

She

is en attractive

girl with enthusiasm
that io'unmntched by any of the leuy young
people who have
worked for on. She is reliable end deyendable. and
I recon—
oend her highly.
Should ohe

cell, I

end ohaxuing

would be

give her for openings the:
broaden her experience.
may

1974.

M3

beet pereonel regard:

grateful for any advice you
utilize he: colonte or

may

end

best wieheo for a healthy
Sinoorely yours,
Fink. H.D.
Professor of Psychiatry
Hex

MF/oie

P.S.-I

hove

sent the

some

letter to Ernie

Bertmenn.

�</text>
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27 Dncaﬁbor 1973

Exact: Barenann. v.9.
810.9 Laboratory
Boston stat. Hospital
591 Korean Scrccc

Beacon. Haslschusutts 02125
DUI: Krutcz

I am writing to rnacmnund His: Ctrolyn Poinlct. who 1.
intcruntnd in continuing ha: ndueation 1n ﬂatten and may call
you for :dvleu s. an a paoltlan II a :uccarth assistant. 8h.
x:cdunc.d colby 0011.3: with ouncllan: srldun 1n Jana, 1972,
and has boon with an than: 9:0: 18 months. 8h. has pgrele1~
patod 1n thn work a! thin lnhargtary fully, including recording of EEG. procuaaing of 316 using tha IBM 1800, utntistiaal
nanlyucs and bohtviorcl cvsluntionn during human Olpﬂrtllntl**
all of thlit in Ill. voluntanta.
3h. 1: an attractive cal churning girl with auchuaiasn
1n u.nnt¢hnd by any of ch. many yuan; pooplc who hnvn
varkcd 29: up. 8h. 1: raltnblo and dnpandablo, and I rtcanw
Isud but highly.

thlt

Should aha

any sivn

call, I

would

h.r for opcnlaas that

brand‘n ha: ouporlnncn.
1976,

Hy

has: personal rcsaréu

b. grutcful for
any

ﬁnd

any udvtec you

utiliaa hat taltnt. or

but: wiuhcs for a hnnlchy
Sinnarnly yours.

F1nk,u.b.
Prof-Ito: of Psychiatry

Max

uF/cia

P.3.-~I havc tout ch.

'

III! lotto: to Jo. react.

�</text>
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                    <text>TBSBGBhosB

21 December 1973

Fritz

A. Freyhan, M.D.

Editoruin-Chier
Comprehensive Psychiatry

Street,

2015

B

Dear

Fritz:
I have read the article

H.W.

weanington, D.C. 20009

by Btrauss, g§_gl;, "Inpatient
Alcoholics: Characteristics and Needs," with interest. While
the findings seem supportive of prevalent teachings and add
little that is new, I believe the presentation is sufficiently
well documented to indicate the special risks to which members
of some subcultures are prone. The need for additional attention by psychiatrists to the ubiquitous problems of alcoholism
is well represented. The article is well written, clear, and
deserves publication.

I have two comments. The paper lacks a dhscussion of the
work done by others and the citations seem outdated. carer-

tunately, I am not sufficiently acquainted with the literature
to define specific emissions but a question to the authors may
set their

minds working.

Secondly, on Page 8 the authors cite the APA for not at~
tending to alcoholism. I do not believe this criticism is
warranted. The program reflects what interests psychiatrists
in any year and a less 39.nominem argument is to be wished for.
Perhaps they could survey the nudber or papers sent to a group
or representative psychiatric societies (Society for Biological
Psychiatry, Ortho. American Psychological Association, etc.)
and reflect on the percentage of time devoted to alcoholism
at all such meetings.
Thank you

for the opportunity to review this article.
Sincerely yours,
Max Fink, 24.1).
Professor of Psychiatry

MF/cia

�</text>
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                    <text>m‘w’

mam

..

December 21, 1973
Henk van Riezen, M.D.

Scientific

Develbpment Group

N.V. Organon

Oss, Holland
Dear Henk,

When I received the lettee describing the placebo vehicle,
I read the available regulations. I found none that applied to
IND formulations. Nevertheless, I celled the men at the Division of
Neuropharmacology of the F.D.A., reached Dr. Edward Tocus and
discussed the problem with him. He sent me on to two young associates,
Drs. Kum Kumian and Thomas Hayes. None of the three believed the
question presented a prdblem.

I believe that the formulation is acceptable.
I will

Should you send the supplies to us in the present form,

file

an amendment

to the

IND,

stating that the formulations

used fpr the ongoing studies consist of the type you make available
to me, There will be no objection.

It is probable, however, that should 01—63 come to an RDA,
and you then submit the formulation with a coloring substance, that

the marketing reviewers

may

object.

it

have had severe winter storms here, but
warm sunshine of Palm Springs seems so
wishes for a happy New Year 2
WE

cold today. The
Our

best

is clear
far

Sincerely yours,

Max

Fink,

M.D.

away.

and

�</text>
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                    <text>Aux-=-

7383—83883
20 December 1973

Jovan Simeon, M.D.
Missouri Institute of Peyohietry
shoe Arsenal Street

Saint Louis, Miesluri 63139

Dear Joven:

I am pleased to cooperate with your date analyser and
look forwerd to receiving the cards.
As I mentioned, this Department is growing
very repldly.
here been notified of Federal.ewerda totaling more than
$1,000,000 for the coming year, in training and research, in
drug abuse, and in the peyohopothology of sex. It is highly
likely that this Department will be awarded e special grant
from the State to establish e research center similar to the one
in Missouri at the local State hospital. we eleo have the pos—
sibility of expending the program in mantel deficiency and
retardation at e local State hoapitel.
we

Recognizing your background, I took the liberty of dis—
cussing your credentials with the Chairmen or the Department,
Dr. Stanley Yolles. He would be delighted to here you visit.
Should you be interested in relocating to Rev York,

I

suggest you write him a letter telling him of your interests
end submitting a curriculum vitee. Your letter should indi~
cote that you are well known to myself and Mickey Taylor, who
in now the Director of Residency Training for the Department.
If you happen to know Joe wortis on well, I would indicate
far he is in charge of the mantel retardation program here. that,
My

m

best regards fOr a

happy and healthy lQTh.

.

Sincerely yours,

‘1'“:

«

«wpag—w—wr—vr

Fink, M.D.
Professor of Psychiatry
Mex

MF/ois

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                    <text>e...

/

w”?

73SB~SZSSB

20 Docsmbsr 1973

Dr. Miles Mucousok
Klin. usurofys. Lab.

Sshlgrsnska Sjukhusst
Sjukvnrdofdrvaltuingou l GHtshotg
SWEDEN

Dost Milos:

It

for Hjorth's
I have given your output to Dr. Shapiro and
he has promised to give no s Christmas present of the program.
Should it to running, I will obtain thsso measures in addition
to my usual froqusncy mossurss in my uoxt drug study sud, hopsfully, should have sous information for the ousting in April.
was very kind of you to osnd us the program

analysis of

when

Should

I

come

EEG.

be possihls. I would
it
to Europe in tho

like to visit your laboratory
lsts spring. I shall probably ho

aooompanisd by ono of my daughtsrs, sad
to too sons of tho sights of Swsdsn.

I will use tho occasion

Last month I visited Jiri's laboratory in Basel and was
very impressed with the organisation, squipmsnt, programs, and
enthusiasm of the unit. For the first time since 1966, I beliovs Jiri is hsppy and productive-«although he did complain
that ho was tirsd of studying srgot sud hoped that Ssndoz would

find a

more

stimulating interest.

Voits has assumsd the responsibility of my former labors.
tory with snthusissm and is doing a msguifioont job. He has
‘spporontly convinood the funding authorities to give him additional squipusnt on wall so to out up a lsborstory in Copen—
hsgsn. I set him so busy as I must have boon when I had that
position. Thurs is sousthing about life in New York City that
makes msn run when othsts walk. Hora, in the country. msn walk
and I soon to hsvs plenty of tins to spend with my family. for

'whioh

I

am

most

grateful.

�1

.,

,‘vam v-vyﬁ n-.. -

v

V,

(Nu-um. u.

:

7,. 7'

.57

my

.. v

a

‘.

.,

..,

~.w.~...m_w y._l.,mr,. *vna” I

.7,

W,“ VY

V..-"

.W‘W...1v” . ..

‘

u— ..W V..\.,..

my-“ .. “wt, , _W.,.‘f.,_\-.m.

u

m

W"

bi. Milos

Matousek

mmwnwnqmw-v

Again,

my

20

—2-

December 1973

thanks for sending me the programs, and I hope
some outputs to show you in the spring.

that I will have
My

best regards for

a healthy and happy 1974.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>a

V-‘“

~V’

'-

arr-1r.

--r_v-x~wxmw.-v

mm

w

7383.83988
20 December 1973

Dr. Alexander Levine
Chairman of the anberehip Division
and Fellowship

Anericen Psychiatric Association
1700 Eighteenth

washington, D.C.

Street,

H.w.

Dear Dr. Levine:

I

Dermen

am

pleased to

recommend

to Fbllowahip in the

the promotion or Dr. Robert M.
Psychiatric Association.

American

I have known Dr. Derman fbr more than two years, first
in his role as Chief of the Addiction Service It the Manhattan
Veterans Administration and lately as Associate Professor in
this Department. During the past year I have worked closely
with him on e number or academic essignmente. In these relationships, I have elwnye found him to be friendly, modest, reliable,
and innovative. an accepts responsibility and he: carried out
the missions of the Department admirebly. He in e well-qualified payehietriet with extensive clinical and administrative
experience. In his present position, he is actively involved

with community education.

vw—x-

‘vzu-

v:
-

I am.pleeeed to recommena him for Fellowship, for I believe that he has already demonstrated the attributes of this

honor.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

:W—"mmwmw

EARA,

1951

President, Nassau (N.Y.)

District Branch,
MF/cis

1959

�</text>
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                    <text>mam—:7

7333-83183
20 December 1973

Barrett Scoville,

M.D.

Division of Neuropharmacology
Food and Drug Administration
5600

Fisher's

Lane

Rockville, Maryland 20852

“um-”w.

vw-rvw»wv'w‘&lt;v€"“"

v
~/-‘

v

Dear Barry:

I am enclosing a copy of a letter which I sent Al Gardner
in July. In that letter, I was proposing to discuss the use
of quantitative electrophysiology to assay the bioavailability
of CNS—active drugs.
I think the methods are now sufficiently developed, both
in the quantification of EEG and the statistical processing of
EEG and behavioral data, to allow more extensive correlations
of data collected to assess such questions as the rate at which
a drug affects the brain, and comparisons of different dosages
and probably different fbrmulations for rate and degree of ef~
feet.
I

enclosing a preprint of a report which summarizes
our experience to December, 1972; and a reprint published in
1971 on statistical methods used to analyze rate effects with
intrawenous pehtothal.
am

Should the Division of Neuropharmacology wish to assess
these methods, I would be pleased for an opportunity to dis—
cuss the experiences and the potentialities in detail.

It

was fun

flying with you.

and healthy i97h.

My

best wishes for a

happy

r‘,-n-.n:

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.mvwmwﬁm‘mtﬂ?

MF/cis

Encls.

�</text>
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                    <text>7383—83283
20 December 1973

Gerald L. Klerman,

M.D.

Superintendent
Erich Lindemann Mental Health Center

.

._

.....

Government Center
Boston, Massachusetts 0211h

.

"w...“

Dear Gerry:

V...”

MW...

but

I

was

of your Committee at the FDA
especially pleased to read the write~up in Psychiatric

have heard of the work

I found the missions of the Committee of considerable
interest because the present methods of affecting change in
regulatory policy do not allow fer a regularized input from
news.

the academic community.

In this regard, I am taking the liberty of sending you
cepies of letters I sent to the FDA. These is much concern
with prdblems of drug equivalence and bioavailsbility. EEG
measures to record the central effects of psychoactive drugs

and studies done in this laboratory and similar laboratories
in St. Louis, Basel, and Goteborg provide optimism that these
techniques may be useful in answering questions to which blood
level measurements are now applied.

Should it be within the purview of the Committee, perhaps
you could consider a review of the ayaiaable data with an eye

to undertaking collaborative studies.
My

best regards for a successful

new

year.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

Encl.

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                    <text>.r.

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.

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q...

~v-m»~.,....—

&lt;_,_~—w--v&lt;

fw

~—w~

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7383-83633
20 December 1973
Leo

Hollieter,

President

M.D.

American College of Neuropaychopharmecology

Veterans Annihietration Hcepital
Palo Alto, California 9&amp;305

Dear Lee:

vriting this letter in regard to the latest meeting
Firat, I vieh to commend.thc Arrangements Comp
mittee with their success in providing ideal weather and a
moat aalubrioue environment for the meeting. I hope the Council
will consider an annual return to Palm Springs with a high pri~
ority.
I

of the

am
ACHP.

I trust the painful ieauc or the invitees has been cue»
ceaetully resolved. I was embarrassed by the Council and the
Secretary, as were some other members of the Coylege, and I
trust this will not recur.
»

I am writing specifically to raise a qucetion with regard
to the arrangements. The registration the of $25.00 was tied
to a dinner and the free distribution of alcohol. Since not
all members of the ACE? drink alcohol, it seems that we are

subventing alcohol users and in some rather indirect way cn~
couraaing alcoholism. As a college dedicated to drugs and
their abuse potential. I believe we should be more sensitive
to the problems of abuse and not be put in the posture (even
it noble and fund~raiaing motives are involved) of encouraging
alcoholism. Alcoholics ought to pay their own way. I would
hope that the Council would make it possible next year for
there to be a separation between an attendance Ice and dinner
and alcohol fees.

more important reason for writing this letter
do with my desire to suggest that the Program Committee
consider a round table or symposium on the effects of poly—

has

Finally, a

to

peptides on brain function. During the past few years, a hunter
of scientists, both in the united Etntea and Europe, hare demonstrated that ACTH and M33 and their derivative peptide chains
may have central effects which are highly specific with regard

-1-

�goo

Hollister,

M.D.

«2*

20 December 197;

to functions of memory and extinction. Scientists working in
this field include Moaongh, Gold, Rustin, dsWied, Small, and

Esooan. my guest ax the ACNP, Dr. Bonk van Biases, in a phar»
mooologdst actively involved in this research program.1n Holland
and wort: closely with Br. David deﬁlod. At my suggestion,
Dr. van Riezun is willing to provide some of the funds neces—
sany to invite the purtioipdtion of scientists for such a sympoa~
inn, should tho ACE? wish to hold such a session and, secondly,
should its own funds be inadequate.

I thank you for the letter regarding the HEW regulations
and tho Eudoral Beggater. I have tent a letter similar to yours
on behalf of tho APPA-a oopy of which in anclosed for your
interest. I will be grateful
you would keep me apprised
of one evaluations of these guidelines 80 that I may be able

if

to present then.to a wasting of the Council and the APPA during
the first week in March. That will be in sufficient time if
the 90~day extension is allowed.
My

of the

best wishes to: the success of your tenure as President
and my best wishes for a hoopy and healthy 197h.

ACE?

Sincerely yours,
Fink, M.D.
Protozoa: of Psychiatry
Mn:

MF/ois

Encl.

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                    <text>7383-83783

20 DeceMber 1973

;

Jeroma Levine, M.D.

V
.

Chief

1,

”"7"

Psychopharnaoology Reacnrch Branch
ﬁctional Institute of Mental Ebalth

‘fW-I‘

nygw‘w,

5600

Fisher's

lockvillc,

5‘va

Lane
Maryland 20852

-:

Re:

m
w

Dear

mmwv

MK

2hoao

Jerry:

I fbund our discunaions in Palm Springs concerning my EEG
program most helpful. I haw. reviewed the work now in progress
and I believe it would be better tbr an to submit a continuation
proposal fbr the May 1 dandlinu. This would permit me to providc

'I-z-

r-u
v
'n‘

“wwwsrmwmn'wr-rr

much

batter doeunontaxion.

Again, many thanks and
91'3"!"

my

best wishes for a healthy 197h.
Sincoraxy yours,

A

Fink, H.D.
Professor of Psychiatry

"

Max

”5‘21?”

ﬂylcin
WTW

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                    <text>T3SB~83583
20 December 1973

Richard Wittsnborn, Ph.D.

Univorsity Professor

Interdisciplinary Research Center
Rutgers University
New Brunswick, New Jersey 08903
Dear Dick:

I am.utiting with regard to the ACNP~FDA Guideline Task
Force Report dated October 1, 1973. I have not responded to
that mailing earlier because I anticipated a meeting with the
group in Palm Springs. As that meeting did not take place,
I on taking this opportunity to respond with some comments.

I

three major sections carefully and, in
of the Introduction, believe that this document may be
used as part of the regulatory actions or the FDA. My com~
manta are based on this cvcntusl use. With this‘in mind, it
seems to no that brevity is a virtue to be highly commanded;
and negative ststemcnts, however,wcll intended. should be
View

have read the

carefully cxpunipd.
My

principal criticism of the documsnt, therefbrc, is
1 and 2, the Introduction and General Principles,

that Sections

are much too lengthy, much too specific, and contain a number
of pcjorativc ststcmcnts which may reflect the opinions of
the writers but should be rcviewod carefully. I believe that
those sections should be reduced to no more than a tow para»
graphs of introduction.

I note that many comments are made in the document which
ordinarily would carry with them citations. I am struck that
this lack of citations losses the reader with no recourse but
to assume that the statcmcnts are opinion and not based on
experimental tact. Nevertheless, there are many statements
which are based on czpcrimcnts and I believe that citations
should be provided.

�Richard Wittcnborn,,Ph.D.

—2~

20 December 1973

Guideline Statements, Section 3, seem well written and
clear.
quite
It is in these sections in particular that cite»
tions ought to be requested.
The

Specific examples upon which these opinions are based
follow.
Introduction (Pp. 3-5) contains such pejorative state~
as, "The ‘gold rush' into the manufacture...," and "This
possibility is already viewed with alarn'hy some drug houses'
research d1rectora...." Page 7, Line 1, contains an error, I
believe, that "June, 1950," should be "June, 1970." As an
example of the specific nature of the Introduction which is
undocumented, is the recommendation that certain rating scales
be used, such as the IMPS, BPRS, and WPRS. Nowhere does it
state the use to which these scales here already been put, and
the reader is left with a catalogue without any clarification.
Perhaps citations indicating those kinds of studies in which
these scales hare been used successfully would be helpful.
Indeed, a simple count of the number of studies each of these
scales has been used in might be useful information.
manta

The

Another example is the reference to psychomotor tests
(Pp. 21-22), in which it is alleged that a "Hacker Cube drawing or a reversible staircase drawing has been seen to increase

in response to effective anti-depressant medication." I do
not think that this statement would be substantiated by the
reference, for when we tried this test we failed to discrimi—
nate imipramine from chlorpronasine. Perhaps someone else
was more successful, and the citation should be given.

In Section 3, "Antianxiety Agents," I found a number of
gratuitous statements. For example, on Page 9 the paragraphs
on indirect verbal measures, indirect clinical measures, phys~
iological measures, and behavioral measures each start with
an assertion followed by an opinion. For example, "These
measures provide estimates of affective states and other areas
of function through content analysis of spoken or written verbal
samples from the patient, by carefully trained technicians according to procedures specified in detail," is followed by
"Although these procedures are less subject to some of the
distortions encountered in direct measures, they are difficult
and time consuming," The first sentence is useful; the second
an opinion which, if true, should be documented. I believe
the first sentence can stand in the record without the second.
This is true for the other three paragraphs as well.

I hesitate to suggest an addition, but it seems to me that
the section on Phase III studies (Pp. lh-l?) might raise the
question of the degrees of effettivencss of certain compounds

�’73--

,.

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—w—'\:-m

.3-

Richard Wittenborn, Ph.D.

20 December l973

with continued use, i.e., "tolerance." I think this is an
aspect of Phase III studies that in important for the pro—
tection of the user.
On

Page 12, the

"Criteria of drug effect"

make no recom—

statistical prOblems involved in such
an evaluation. It is here, in particular, that the Committee
can be very helpful in providing materials to the academic community and the FDA regarding statistical procedures and their
pitfalls. Citations would be most helpful, particularly with
regard to the problems of aﬁpll samples, parametric and nonmandation regarding the

parametric statictics, and.multivariate computer analyses.
A note as to the meaning of levels of significance may or may
not be added.
Some

of the

comments

with regard to the anti—anxiety sec-

tion are equally applicable for the antiudepressant section,
particularly the need for references and guidelines to statistics.

In addition, the Opinions of the Committee are expressed on Pages
12-lh with admirable reatraint~~except Items 7 and 8. I hesitate to suggest that EEG measures provide evidence of efficacy
and indices of change at least equivalent to verbal aample techniques. Indeed, in the studies which I carried out with Bob
Khhn and Joseph Jarre more than 10 years ago, we found a greater
sensitivity to EEG measures than linguistic measures. I have
followed Lou Gottachalk'a data with interest but do not believe
that the distinction implicit in Items 7 and 8 can be substan—

tiated.

‘

Page 17 in Phase III studies, the Committee recommends
a comparison of new anti~dapresaants with tricyclica, MAO inhibitors, and psychomotor stimulants. It might be useful to
suggest that comparison of new treatments should be made with
On

the most effective anti~dspreeaant therapy available, that of
repeated induced convulsions (BC? or ICT).

I wish to

command

the

members

orally excellent set of guidelines.

of the Committee for a gene_
Sincerely yours,
Fink, an.
Professor of Psychiatry
Max

MF/cis

cc:

Klerman, M.D.
E. Uhlenhuth, M.D.
G.

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Murray Winngr, I‘LD.

Merrill

Mamas

Amity Road

Cincinnati, (bio
Dear

45215

Way:

InfollmdngupmsmdjamImmmme-

gazdjngtlmaffectaofantihistminicagmtsmmsmﬂnmtby

mmdmummommafm

FadngonamBerry.
ofandhiatmhﬁcagentsmﬂpxwﬁemwimﬂmttheeﬁm
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antﬂziamhﬁc men can be discriminated.
My

(Av-WI:

best regards for a

may

1974.

Sincerely yams,

vrwmtw

n»

IP‘T‘.‘

-y—nu

.-

Max

Fink, Md).

Professor of Psychiatry

W/cis

V

�</text>
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                    <text>7BSB~82983
20 December 1973

Peter J. Fell,

Fisooo, Ltd.
Loioeotorshire

M.D.
L311

OQY

ENGLAND

Peter:

Dear

I look forward to your visiting my laboratories at Stony
at January 17. I underetend from your secretary that you
will be arriving from Toronto. There are connections to two
Brook

new York

airports, LaGoardia and

John P. Kennoéy.

The beat way to reach the Buivereity

in

by lioooeine from

either airport—~travel time is 1-1/2 hours. When you arrive at
either airport (LaGuardie is 10 minutes closer). oak for the
neareat euborban limoueine telephonee and use the one marked
"Long Island Limoueine." They will give you the eohedule for
the next limousine to Stony Brook and you will be picked up at
the terminal, near that phone. -Tolephonee are at each major
terminal. The coat ie $15.0U.
You may

either take a taxi

from the limousine depot at
(The
from

call my number and I will pick you up.
railroad station and limousine atop are eight minutes
Stony Brook or

campus.)

Should

it

be poeeiblo for you to change your schedule and

arrive the night before,

you are welcome to etay

drive to Stony Brook with

airport at (516)
my

466v54ﬁ4.

me.

at

In that event. call

my home and
me from the

I look forward to your visit. My beet regards to Vi and
boat wiehee for a happy and healthy 1974.
Sincerely yours.
Fink.
m
Proteeaor of Psychiatry
MOD.

MF/oio

�</text>
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                    <text>7383m83h83

20 December 1973
M

E

M

0

R A N D U

M

To:

Stanley F. Yolles,

From:

Mex

Fink,

M.D.

M.D.

Subject: Guidelines for the Evaluation of Students

'i
-

we?“

.1“:

:
"1'17:

:H

I

have read the Guidelines, dated December 1h, with in~
terest. I find them acceptable subject to two comments:

1)

The_progrem depends on an active Committee
on Academic Standards holding regular meetings
with a senior person as chairman. I hope the

faculty understands that this is another inn
portant commitment of faculty time. Should the
Committee meet irregularly or should it serve
Eggbtorme only, I believe that both students
and faculty will be disappointed.
2)

It seems that grades will not be given. It
seems to as that grades are s shorthand way
or indicating to a student that he is either

perfbrming very well, well, acceptably, or

,....-»

poorly in relation to the faculty's expecta—
tations. I think that the grades should be
maintained, but nowhere is a grading system

v“-rrz-*'W"w-'z4—wr;.

explained.

5'
..

MF/oie

�</text>
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                    <text>.

"me'JF'I-wawwrv

w‘r—Awry-I-

7333-82433

20 Decambcr 1973

Costco Stefania, M.D.
Deparcutnt of P:ych1atry
Untvaraicy of Achcns School of Modicina

Bainition Hospital

76, Vasillilais Sophia Avenue
Athena . Gram
.

.
.

wrwgrgnmqgmw

Boar Cactus:

In chanting the informntion of ch: withdrawal data, an lack
tha drug node (a: Evnnaclidis and Ermidil. Can you pleas. tell
as tho code (A or B) for Station- 1~3 and 4-6 for each of abuse

MM

Many

,
a

thanks.

m
a",

Sincuraly yours,

Emma»

by

.
l"—

‘

HI: Fink,

'jt/‘rﬁf‘yy

lF/cia

ml

‘

‘

fijﬂ‘imr'ﬁ'v

»-4"'"',"W4¢:mi.fﬂ'

-'
{“91

f
TWWW“:

1-f-

f"
.1“?
‘

qsv

M.D.

Pro£0500t of Psychiatry

.3:

0

�</text>
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-»-—

mm,-

7'

rung-vwvwn

7383-82558
20 December 1973

Dr. Miles Matousek

Klin. neurofys. Lab.
Sahlgrsnska Sjukhuset
Bjukvardsfﬂrvaltningen

SWEDEN

l

Gﬂteborg

Dear Miles:

It

was very kind of you to send me the program for

Hjorth's
I have given your output to Dr. Shapiro and
he has promised to give me a Christmas present of the program.
Should it be running. I will obtain these measures in addition
to my usual frequency measures in my next drug study and, hops~
fully, should have some information for the meeting in April.
Should it be possible, I would like to visit your laboratory
when I come to Europe in the late spring. I shall probably be
accompanied by one of my daughters, and I will use the occasion
to see some of the sights of $wedsn.
analysis of

EEG.

Last month I visited Jiri's laboratory in Basel and was
very impressed with the organization, equipment, programs, and
enthusiasm of the unit. For the first time since 1966, I believe Jiri is happy and productive—~although he did complain
that he was tired of studying ergot and hoped that Sandor would
find a more stimulating interest.
Voita has assumed the responsibility of my former laboratory with enthusiasm and is doing a magnificent job. He has
apparently convinced the funding authorities to give him ad—
ditional equipment as well as to set up a laboratory in Copen—
hagen. I see him as busy as I must have been when I had that
position. There is something about life in New York City that
makes men run when others walk. Here, in the country, men walk
and I seem to have plenty of time to spend with my family, for

which

I

am

most

grateful.

�"a...”

Wyn-v,

.u-

Dr.

M1103

Matousak

Again.

that I will
My

-z-

20 Dtccmber 1973

thanks for sending me the programa, and I hope
have some outputs to show you in the spring.

my

best rusards for a healthy

and happy 1974,

Stncnrely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>73AP-827AP
20 December 1973

Diroctor
Hationnl Institutes of noelth
9000 Rockville Pike
Bethesda, Maryland 20014

Roz

Departoont of Health Education

end welfare
Rational Institute of Health
Protection of Human Subjects

Policies sod Procedures
Flgeral Register. Voluno 38,
Fridoy, Rovouber 16th. 1973

D“! Sit:
behalf of the Anorioon Peyohopathologiool Association. we
request an attention of ‘30 daye of; the time to reply to the pro~
posed polioioe noted above. This extonsion would permit us to
contider tho ieeuce roiood in the proposed soi‘olineu at our enuual oneting in March.
On

The proposed regulations are unusually important in that
they any iapair studies vital to the health of the citizens of
our nation. rathor than eneourege than. The issues extend be~
yond the imoodiate problems of monitoring the human rights of
children and the nontolly 111. Because an believe that the axonoies involved have sivon much thought to the production of these

it

bolievo it impossible for us, as well as others.
suidolinon,
to respond mooniasfully in the tow wueko einoo the policies were

publiehod on November 16.

If such an extension is granted, and I hope it will be. I
you will have e constructive rosponao from thin Association.

believe

Sincorely yours,
Fink,
President

Max

MF/oio

bcc:

Dr. Leo

Hollister

M.D.

#221

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                    <text>73AP-828AP
20 Doccmbor 1973

Jonathan 0. Cole, H.D.

Temple University

Phlladolphia, Ponnoylvania 19122
Door Jon:
At the ACE? matting

1t ocomod important to provide an apportunlty to respond to the proposed policy concerning resonrch
in man. I have sent the oncloood letter on behalf of the APPA.
that

you must ho involved with the formulation of
if would be possible for you to
present a proposed roopoooo on behalf of the APPA at the Council
wanting in March. I would be pleasud to work with you on this
and to out said. the tins beforo Council at your convonioooo.

tho

Knowing

ASH?

my

response, I wonder

it

best regards,
Sincerely yours,
Max

MF/cls

Incl.

Fink, M.D.

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                    <text>'i

WWWA

.2:

02

73AP-826AP
20 Docnnbcr 1973

Garald L. Klerman, M.D.

Suparintandent
Erich Lindcmann Mhntnl Health Cantu:
Government Cents:
Boston, Mhasachuactts 02114

Duar Gerry:

records are incomplete, but this lettar from A1 Freadmnn
suggests that no rcviov the £110: for an invitation to Dr. June
Christmas.
my

If aha was invited, pcrhaps thc Mbmberahip Committee would
reconsider extending anothcr invitation.
Ifisho has not bocn nominated, perhaps w: can write her,
taking for but C.V., and thnn proccsl it with letters of rccom~

mondation from.A1 Ergoduan.
My

bcst ragards,
Sinccrnly yours,

m Fink. Hobo
MF/cis

�</text>
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«r

J».,,_,‘__..,..V....

'

73SB~81883
m‘mwwmnavu-WF'

19 December 1973
‘3
‘

—

11mm

1.7mm

~v-v«'-vo~"!01"rr

.W'Vinrvu-grm—«w.

Julian J. Leaky,

Ph.D.

Executive Secretary
Clinical Projects Research Review Committee
Division of Extramural Research Programs
National Institute of Mental Health
lOCZS--Parklewn Building
5600 Fishers Lane
Rockville, Maryland 20852

Room

Re:

'5'"

MB

25608-01

A

.«—

»-

7"

gq.
w,

Dear Jack:

I have read the proposal,

"EEG

and

Changes during PsyDr. Reilly proposes

VER

Reilly.
psychiatric patients (N - 24).
In addition to a psychiatric evaluation using rating scales for
mental status, he proposes a systematic EEG recording for back—
ground EEG by visual interpretation, and for the visual evoked
response. Recordings will be done prior to drug treatment and
at weekly intervals for the duration of hospitalization, for at
least six weeks. He also proposes monthly recordings thereafter
between the second and sixth months. The date are to be snalysed by complex statistical procedures of a multivariate type
by consultants who are experienced in statistical analyses but

chiatric Treatment" by Dr. E. L.
to examine a small population of

not

EEG.

The mission set by Dr. Reilly is a most commendable one.
the problem and
My comments can be divided into four sections:
and
conclusions.
methods, facilities, significance,

1.

Problem and Methods

The problem selected by Dr. Reilly is a significant one.
In the description of the EEG recording and visual analyses,
he describes acceptable methods reflecting his experience as
an electroencephalographer. However, to describe a project in
1973 using visual description methods of a decade earlier may
reflect a lack of experience with newer methods of EEG quan—
tification. If the choice is based on data, then he should

~'»£Jﬂ'M"w":/“I

-1-

�.-

.....A.

J. J. Leaky,
explain

problem.

I

-2-

Ph.D.

why he uses

19 December 1973

non-quantitative methods for a quantitative

concerned with the diagnostic criteria for psychiatric
It is unclear whether Dr. Reilly has the experience
to select patients carefully, as the problem requires. (This
question should be answered in a site visit.)
am

evaluation.

I am also concerned with the one-to-two-day drug-free period
prior to the initial EEG. Considering the wide use of drugs,
varied dosages, etc.. this is inadequate. I do not have a good
solution, but I would recommend placing all patients in a defined
group on the same medication for a specific period of time before
the

EEG.

issue of diagnosis—related EEG measreported that the die differences were
a more parsiménious explanation of the differences found between
schizophrenics and depressives. Dr. Reilly does not indicate
an awareness of this major pitfall in such research.
ures

When we

some

examined the

years ago,

we

Thus the issue of quantification, psychiatric diagnosis,‘
medication and age controls, in addition th the small sample,
make me question the likelihood that the goal will be reached.
The application is also unclear as to whether VER, or resting
are the foci of the study. The application lacks a specific
hypothesis reflecting potential effects in either measure.
EEG,

2.

'Facilities

The physical facilities seem adequate to the task, although
I anticipate that Dr. Reilly will find that recordings made on
a Becknsn recorder will not be satisfactory for computer pro,

ceasing.

”n“...-

.r,

:y-rvlcn—‘vr

«mnp-

.r.

”,1

”WW,

wwwme

1“,.

rm—

Dr. Reilly's training seems adequate for EEG and his coworkers are physiologists and statisticians. The participation
of a psychiatrist (a behavioral typologist) seems lacking in

the study.

'

The funds requested seem unusually modest. Considering
the talents ascribed to the consultants, the sun requested
($3,000) and the computer tine ($600) are inadequate for the
analyses described in the text. While modesty may be a factor,
I believe lack of experience is a better explanation.

�J. J. Leaky. Ph.D.
3.

19 December 1973

~3~

-

Significance

of physiological indices for the classification
of the mentally ill and for the description of changes in psychiatric treatment are very important issues. The problem has
The problem

been approached by many investigators.

The

literature survey

presented by Dr. Reilly is adequate, although there are significant omissions, particularly the studies of Shagass, Callaway, and Monroe. Again, the references to clinical electroancephalographers, especially those associated with Knott, Wilson, and Doty, are well reported, but the contributions to this
problem by psychopathologists are lacking.
4.

Conclusions

cannot help feeling that Dr. Reilly is an enthusiastic
in climbing a small hill in the lower
Appalachian Mountains, who became excited with the possibility
of scaling Annapurna. The goal is commendable, but he seems
to have learned only the rudiments necessary for this task, and
1

young man, experienced

I

do not

believe that the prognosis for success is favorable.

But how can one encourage such an

sible to

recommend

that he spend

it poswith Callaway,

interest? Is

some time

Shagese, J. Small or Itil to obtain additional psychiatric
experience relevant to the problem which interests him?

I would also suggest, if one can, that he become acquainted
with Neil Burch and Peter Kellaway, both in Houston. These men
understand EEG measurement and can probably contribute to his
data processing. He should become acquainted with either Bernard
Salteberg of Tulane or Stanley Feldstein of the University of
Maryland. Both of these men have devoted many years' effort to
the statistical analysis of complex EEG data, Seltrberg with
Burch and Feldstein with me. (I would ask that he be advised
of the work of Dr. Burdh, for on Page 21 he says, "There is no
other source of the programs in running form available in Houston."
It is my understanding that Dr. Burch has had quantitative EEG
programs for background 339 and probably AER in running form
since 1966.)
'

I trust these

comments

are helpful.

I believe a

be encouraged to climb mountains when he has had

man should

sufficient

ex—

perience to handle these problems-~for climbing the mountain that
he has targetted is a worthwhile experience.

�“0 “a, -m.
w-

‘

._.v,,.‘

A

,.

&lt;

.

V.

J. J. Lalky, Hub.

-4-

19 Dgcambat 1973

u,v

..

.

Thank you

Sinceruly,

.v-:rw.&lt;wmn—vu_.-—.A..Y....

Fink, MOD.
Prafansor of Psychiatry

M‘x
-.wr7l=r

a,”

H

for the opportunity to rcviaw this application.

Hrfcis

M

�</text>
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                    <text>.w.m.y——W.,ﬁ,¢._

"rum—y.

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.w

u:

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-

..
~.

73SB~819SB

18 December 1973

Dr. P. Borunotclu
Laboratoiro do Psychopharmaeologlo

Hourophyoiologlquo

Hopital Psychiatrlquo do

Villajulf (Solon)
FRANCE

Door Dr. Boronstoin:

I have recoivod your reprints and thank you for thinking
of no. I think tho ayatomatio nature of your studio. with the
bunnodiaoopinos to very helpful, for we or. now automotins to
rolato 386 changes with blood levels.

I am taking the opportunity to wish you the boot for 1974
and to tell you that 03:11.: this your I moved my laboratory
from the ﬂow York Modlcal 001103. to Stony Erook. I would ap-

precitco rocoiving any othor roprinto at this

now uddrcno.

Stnooroly yours,
Fink, M.D.
Profoooor of Psychiatry

Max

MF/cia

�</text>
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                  <elementText elementTextId="103804">
                    <text>V‘W-u—Im.

‘21.:

.wmvmx.

~

y

rswrwvwr a“;

-

.

imm 1W

,

.uuo-m mar-u
7

,

-

*‘--'rv&gt;'v-vr.

"..mm.jnlm»any. my“. «yen-V

-V1u:wg-1m~7‘g' A...

.

. In”
.
.rrnrwmr’l-

.

guy-1‘5.

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.v.»

we.“5“.7,“.
.

December 17. 1973
Dr. Alex
Old Post
Rye, New
Dear Dr.

Carlen
Road

York

Carlen,

.—

lb."

M

Wm,

r—w—w-m

.

.1..."

-mmwvmmw—

A,

e,

.
-

'Lefkowits

I

pleased to recommend the elevation of Dr. Henry
in the American Psychiatric Association.
fellowship
to
am

Dr. Lefkowits was a resident in psychiatry at Hillside
Hospital in l957~l959, and then remained at the hospital for an
additional three years as an attending psychiatrist. During that
time he was active both in the treatment of patients and the train»

inig of residents.
of my division.

He

also participated in the research programs

Since leaving Hillside, he has been in active practice
in Uestchester. From time to time, I have heard of his work; most
recently, in his role as consulting psychiatrist to the elderly
at the Guild for the Blind he has worked actively with my mother
who

tas a social worker at that institution.

In these relationships, I have always found Dr. Lefkowits
sincere, dependable, and considerate. He is a fine physician. In his
recent interestiin community activities, I believe he will make the
contribution which we would expect of Fellows of the A.P.A. I
endorse his promotion and election without reservation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Fellow, APA, '51
Former, President, Nassau

NP

Society

~

.

—

�</text>
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g;

‘uvn‘l:pr‘w-r:lv~wv

4

www&lt;wwww

7358-81783
13 Decsmbsr 1973

Joyce G. Small, M.D.
Lsruo D. Carter Memorial Hospital
1315 Host 10th Strsst

Indianapolis, Indiana 46202

Dear Joyce:

the

I have submittsd the protocol for the study of 01-63 to
As I understand the regulations, you may procosd with

FDA.

this study since this is a supplement to an ongoing IND. As
soon as I receive the acknowledgment of receipt, I will send
it to you.

any I ask that you send ms 3 copy of the conssnt form that
you are using for this study? Also, pould you indicate for my
records the name of the committee and the dste when this protocol was approved for study at your hospital. I need these two

bits of information for
my

my

records only.

best regards,
sincerely yours,
Msx

Fink, M.D.

Professor of Psychiatry

MFZois

Enol.

�</text>
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13 December 1973

Sidney Marlin, M.D.
Rsaosrch Division

Station H
Csntral 1011p,

New

Ybrk 11722

Dear Sid:
Thank you for continuing to send your reprints. The
latest on psychopathology in methadone is of special interest
to Don Swanson.
to us and I hsve sent

it

I would spprscistc your changing your address of record
from New York Msdicsl Cellos: to Stony Brook.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/oia

�</text>
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                    <text>"1-“

-‘
'

7383-80783

11 December 1973

Federation of American Scientists
203

Street. N.E.
0.8. 20002

C

Whahington,

”xv-"mum“

Gentlamen:
m

"Wm-

I

would

Good

like to resign

from membership

in the

PAS.

luck in your efforts,
Sinceraly yours.

War

,_,,m-..wrm_

Fink, M.D.
Professor of Psychiatry

Max

:

MF/cis

�</text>
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                    <text>_’.~.Wr~a'va.
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7333-80853

11 December 1973

Thelma Jones, M.D.
8

Harvest Drive

Scarsdale,

New

York 10583

Dear Thelma:

Please accept my thanks for your long and helpful service
in the evaluation of narcotic antagonists at the Metropolitan
Hospital. I have found your enthusiasm and cooperation inval—
uable in supporting our explorations into new use: for untried
drugs. Without your help. our evaluations of naloxonc, naloxone
pamoate, levomethadyl, ciclazocine, and many others would not
have bean successful.

best wishes for the health of your family
cess of your practice,
My

and the auc-

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

W

�</text>
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                    <text>'
UV“

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7333-81253

11 December 1973

William H. McGlothlin, Ph.D.
Department of Psychology
University of California
405

Hilgard Avenue

Los Angeles,
Dear

California

90024

Bill:

I received your card requesting a reprint of our studies
of chronic hashish users in Greece. The abstract which appeared
in Egychogharmacology Bulletin was in error, for I assumed that
that discussion was informal and would not be published.
Castes Stefanie and I have agreed that the material now
being completed will be aummarized in a series of reports ema—
nating from his laboratory early next year. When those are
available, I will send yhem to you. In the meantime, we have
been delighted with the data, which demonstrate a variety of
long~term effects of hashish use which seem to put this drug
back in the pharmacology texts as a psychoactive compound ﬁlth
the usual dose response characteristics, active CNS effects,
high penetrance to the CNS, and moderate rates of tolerance
development.
Thank you

for your inquiry.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>v"

wvnmzm

.m—

”-1-."va

.,

WW"

:‘

7383—81153

11 December 1973

Grass Inotrumnnt Couynny
101 Old Colony Lane

Quincy. Haasachusetts 02169

Att.:

Hz. Lunacy

Gentlemen:
WOuld

my

oifico

you please ship 24 tabs: of EEG electrode paste to
at Stony Brook and bill tho Internationnl Association

for Psychiatric Research.
Many

thanks.
Sincerely.
Fink, M.D.
Professor oi Payehiatry

Max

MFfois

�</text>
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".mevu'

7388—80983

.mm-wvr—

11 December 1973
«rm

—

»F-.

v.

"ILVU

'

I

Mr. Robert Cuddihy

Sandoz~Wander,

East Hanover,

Inc.

New

Jersey 07936

Dear Mr. Ouddihy:
About two years ago I presented some data at the Drug
Information Association meeting. I was assured that it would
be published in a forthcoming issue of the BIA Journal. When
I had not heard from Frank Liaka, I write to him and in his
answer of June 22 he indicated that I would hear from you.
The information presented at that time has already been
published elsewhere and I wish to withdraw that report.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis
Encl.

�</text>
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11 December 1973

I.

.

A

“Hug—M»

“.4

Mslbourne Greenberg, M.D.

88 South Bergen

Freaport,

New

Place

York 11520

Dear Mel:

”ﬂu—7",

a.

f
{

;

I have read your son's transcript

and wonder why he has

not applied to this medical school. I inquired and they are
unable to find a record of his application.

I wish

him the

best of luck.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cia

�</text>
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11 December 1973

Laurence V. Faye,

Jr.,

M.D.

Assistant Chief Medical Director
for Acedmic Affairs

Veterans Administration
Department of Medicine and Surgery
810 Vermont Avenue, N.W.

Washington, D.C. 20420

Re:

112F3, 3 December 1973

Dear Dr. Faye:

for your invitation to participate in the V.A.
Orleans. I regret that I was unable to attend,
returning herewith the letter of authorization.

Thank you

meetings in
and

I

am

New

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis
Encl.

�</text>
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                    <text>731-8031

11 Decamber 1973

Dr. Dinahaw R. Doongaji

3rd Floor
Bombay Mutual Terrace
Sandburst Bridge
Bombay 7
INDIA

Dear

Sir:

International Association for Psychiatric Research,
Inc., is not a membership society. The Association supports
psychiatric research through grants and awards for fellowships.
The

Thank you

for your inquiry.
Sincerely yours,
Max

MF/cis

Fink,

M.D.

�</text>
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                    <text>Hf.

r.nmw._v--,=...».w,.v

m. ..

“Va-mm “4-,"

w."v‘puv-

mm‘=‘r=u&lt;'wv"‘?'m

---ﬁ'.":r:' w-vvr

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,

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xvii-I"

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'

v
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www

V-v-x\&lt;y~—WU"‘-"“

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WA-vwr-

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73SB~806SB

_
—

11 Doonmbor 1973

Horvoy Blnootono. M.D.
Chairman, Finance Committee
American Psychiatric Association
Council of New York Stat. District Bronchos
420 East 76th Seton:
Now York. New York 10021
’

Dear Harvey:

Euclooed is a check in the amount of $500.00 from Mr. Sidnny
Gimpol on bohalf of Sandoa-Hondor for the 197k divisional wanting.
I would be grateful if you would acknowledge recoipt directly to

Mr.

thpol.

I reztot thot I could not nttond the matting of
I trunt ovorythtng to woll.

Beaumont 11.

Sioooxoly yours.

-

«ﬁavve-vvww

ﬂax Fink, H.D.

«v.

,

Yrofosoot of Paychiotry

(wuuw.

MF/cis

,wrkgg'm

.

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turn-W

Tm».

“C1

0

1‘

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'

'

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'

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"'7‘"-

�</text>
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                    <text>73$B~808SB

11 Doccmbor 1973

Thelma Jonas, M.D.

8

Harvost Drive

Scaradalc,

New

York 10583

Dear Thelma:

Pleaaa accept my thanks for your long and helpful service
in the evaluation of narcotic antagonists at the Micropolitan
Hospital. I have found your enthusiasm and cooperation invaluable in supporting our explorations into new usos for untried
drugs. Without your help, our evaluation: of onloxone, onloxono
pamoate, lcvomochadyl. ctclazocino, and many others would not
have been successful.
'

My

boot wishes for the health of your family and the suc-

cess of your practice.

Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

HF/cia

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                    <text>7388-80138
30 ﬂovamber 1973

Iver P. Stall,

M.D.

Departmnnt of Psychiatry

University of Indiana
School of ﬂcdicine
1315 “out 10 Street
Indianapolis, Indiana 66207
Daar twat:

In talking to Jaye. I indicated that I had not received
corrected
your
gallay. I havc corractod the duplicate and I
am sending you a Xeroxad copy which permits you to check the
corrections which I an suggontina. I would be grateful if you
would glance at chase pagan and crop an n.11ne an to whether
the suggestions are similar to chose mods by yourself, as wall
as any addttional counonts.
my

best regards,
sincarely yours,
Max

Fink. H.D.

yrofoesor of Psychiatry

HF/cia
Encl.

�</text>
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‘
um

.n

.Y,

-

'iawm'Iw-YrTJWYV‘uvI

73SB~799SB
30 November 1973
M

E M O R A N D U H

To:

Sherman N.

Prom:

Hex

Fink,

Kieffer,

M.D.

M.D.

Subject: Grant Pr0p0881-Pagal

3B~C-D

conceived of the central office staff and the University
as "supporting perooonel." As the overall director, we
envisaged you needing two coordinators. The associate profes—
We

staff

sor/director (helf~tine) ie responsible for the clinical aspects
of the progrema in the CBC, particularly in providing aedioal

psyehiatrio coverage for the eaten in the program. The
laboratory director ie responsible for oaintaining the best
standards for laboratory prooeseee. particularly biochemistry
and physiological support services.
and

The ooordinator (a.u. or M.3.w.) is responsible for input
of patient: to the programs, trenefer of patients to other
facilities. and assurance that the prayer permits. laboratory
teats. and rehebilitetivo services are obtained for each patient.
The

bioatatiatioien works with the coordinator

administrative assistant provieee for the collection

tietioal processing

and the
and ate—

of all of the data forms necessary for
the reports requested by the oootrector. He may also assist
the scientists in evaluation of their data.

administrative anaiatent and secretary are seen ea
responsible for the expenditure of funds, payroll, purchase of
supplies. equipment, etc,, as wall as serving the reporting
requirements tor the variant parts of this program.
The

research associate, two researoh assistants, and the
eleetﬁloic technician were included as scientific personnel
to assist the investigators in carrying out some of the atmiieo
The

-1-

�Kieffer,

S. N.

M.D.

listed in the proposal.

~2~

30

Hovenber 1973

recognized that 3+ positions are
merely token personnel, but this was the remainder of the money
left from the figure of $500,000. It represents a research
assistant and electronic technician for the EEG programs; a
research assistant for Dr. Taylor or Dr. Miller; and a research
assistant level to work with Dre. Taylor, Miller. or Der-men.
(We recognise the fact that the funds assigned to Equipment
and not expended in that category can be transferred to Personnel and did so in the plans for the second and third years
of the project.)

gguinuent Requests:

was seen as

we

The equipment

50: the research ward

additional materiel for the 8 beds of the research
office equipment of desks. typewriters, and cel-

unit. The
culators were envisaged as being used by the personnel
word as well as the supporting personnel.

is justified

by the fact that we envisaged par—
senior scientists and that their reports would ordinarily inundete the few secretarial positions
unless we provided the means whereby the reports could easily
be edited. We elected purchase rather than rental, following
the present governmental guidelines that purchase is preferred
where rental costs will exceed purchase for the life of the
project.
The MIIST

ticipation

‘

on the

by 12 or mo;c

Laboratory Equipment consists of two groups of items:
equipment for neurophysiology and peychophysiology. and a
contribution for the genetic studies. In making up this list,
we recognized the fact that Dre. Lodge, Tursky,‘Msrlis. Turner,
and Fink already had equipment to carry out some of their work
and that additional equipment night he provided from the nogotiated requests with New York State for a research center
or other grants to be submitted when the CRC is established.

Alteration and Renovation: After examining the plane
for the research building, we are requesting funds to modify
the facilities for specific research aspects of this proposal,
particularly for psychophysiology, biocthistry, genetics. and
direct patient observation.

It might be helpful to indicate_thet this operationnie
designed to carry out studies in addition to those already
ongoing. The ongoing studies eto:se the V.A. and no funds
are requested for personnel or renovation for the total pro~
gram of evaluation of narcotic antagonists. In the equipmelt
categories, one of the psychophysiology laboratories probably
would he set up at Northport for the narcotic antagonist work;
and the second at the CRC for the many studies of the second
N.B.

section.

HF/cis

�</text>
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              <elementText elementTextId="57882">
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            </elementTextContainer>
          </element>
          <element elementId="48">
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          </element>
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  <item itemId="5789" public="1" featured="0">
    <fileContainer>
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                <elementTextContainer>
                  <elementText elementTextId="106802">
                    <text>“V..."Www.’

("Y—w.

-T.~:-_V~V.

“WV—«Wavymn—q—‘m. ._, ....r

,V

V

.

-

.

..

‘

,

-

v

w.

vymzwwr -

v'~“v.

1!‘¢'IWT‘”'|""“:‘unemnr

”3...»—

wr-mr-'rr‘:“rut-ﬂ!

'hwrl

7BSB~79683
29 November 1973

Dr. J. Silvio
Clinical Drug Scudina Suction

Rational Institute
Drug Abuse
National lnstituta o Mantel Knalﬁb
5600

Fisher's

Lana

Rockville. Maryland 29852

silvio:
Enclosed is a quarterly report of activities undar

Dnar Dr.

tract

Ho. HSM—é2~73-260

cobnr 31, 1973.

for the period July 1,

Con~'
1973, to De»

for naltroxona (No. 10095) and
requesting an initial supply of
naltrexonn of approximately 1.5 grams, which vill allow us
to trant five patients for 30 days at an average dose of
100 as par day.

haw!

Wt

have obtained an

wriitan to Dr.

IND

Ramsay

On acrobat 15, V! requasted permission to transfer the
can of $475 from 8.8. Traval to Foreign Travel under this
comatact to permit our ruprnsuntation at the Nncqus Cone
mitten on Problaus of Drug Dcpondance meeting at Maniac City,
“arch 11-14, 1974. I had writtun to Dr. Ramsey about this
prior to your uppoincunnt as Yrojecc Officer. I would bu

grateful

if

you would

precast this request.

I look forward to wasting you.
Sincerely yours.

rink, M.D.
Protease: of Psychintry

Mn:

HF/cio
Encl.
cc: D. 2. Charlton

W, eat-v.“ own. r :v
‘

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                    <text>v—n‘n’w‘

m
&lt;

711-7981

29

Navrabcr 1973

Euviro Syuta-l Survica Corp.
9

Shirley

Bohnnin.

StIOOt
York 11716

Haw

Gantltuan:
Thus.

bills

tn ah. Earth

rcachcd up aftur Iona ﬁning and rcflnct charsaa
and Spice Sciuncaa installations. Us haw. no :0—
for than. and um would nuagtut that you submit

sponnihility
that. to th. propor dopartnunt.

Th: sultannnt of Deedbat 31 earrint. in addition to that.
threc charges, two ¢h3x3¢s dacod 8/24/73 and 8/30/?3. If my
rocollcction £3 entrant. w0~2778 was ruturrud to J 8 E bncauno
I felt that thin uh. under ch: fixstryoar warranty. If tut: to
innorracz. 91.13; uubnit a tetra-nut with aha Approval of J i E
for payucnt.
a charge for can haunt of filtcri uhiah an had
indicatad anrliar vurn oxeacaivu for our used: an&amp; which wt had
rgfuscd at In narlinr data. At can: paint than. ﬂute shipped
again. not following our zuquunt. Hy anal-tnnt, Mr. Irvin.
aallad your attic. to indiaatc that at had obttinnd an adc~
aunts supply at filter. throngh bid: ‘t n lava: can: and that
BO—28‘9 13

this shipuont should be pickad up.

$1ncar¢1y yours,

NI: Vink.

ass/m
ﬁnal. .

M.D.

�</text>
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                    <text>7383~7QTSB
29 November

v

1973

V'-

.wmmm—

'1

”I-l'r

A131:

611...

H. D.

Hndical Dcvulopucnt Group
H.V. Organan

08:

HOLLAﬂD

Dear Alan:

flurry of telegrlns, the luau: may still be nu—
am
I
In
writing to luunnrlau our prasonz Vitus on ch:
clear.
63‘9‘ 'tmo
With the

Aikl will be arty for thc not: ten days, I will deter
until ald-Dccunbar two GB~9§ utudiot in “blah we will admin»
into: 2.5 as at 3 as GB~9¢. Vb will collcca blood staples
tollawing eh: :ugscatud protocol, fraaua :ham, and ship than
to you in Holland by air .upttlc. I will Tole: arrival in—
fornntlon wall in advance. WI vauld llk that thc chawiats
aaocno

than: nanplna

and

usable and whathtr.63~94

tell

is in

an whatnot chm

3.391.. are

unaunzabla amounts.

Based on ch... data. w. plan to undnrtako an EEG study
with blood nuasutunnnta at 5 IE or posuibly 2.5 we donut.
Rncogniaing ch. difficulty in providing aauplou that look
allkn, an haw: toquaatod eapsulcs of 2.5 I; GB~9A and 5 as

audtriptylnnn. With matching placdbo aapuuloc. u. should
bu able to dallvur nlﬁhsr 3 or 6 cap-ulna to a uubjuet,
making up :ha dltforcnes b¢tv¢¢n ehc tOEIVi dose and total
uuub-r of egpoules by a placcba capoula. we ask for 5 a;
taltriptylonn banana: u. think that 15 n5 is an :daquato and
safe 603.33.

�‘

,

«wk-1.“,

wwwv—gnwu—vv—m

1-w---~W,Awuwv~

"'"1‘1'

‘w—V‘

x

law-”4‘ wan-a-

.

-rs

.va—-

a

«raw

Alan GileqlAK.D.

..—

:

,

~

"VVWW'WWJ-wh-wr

,

«2-

"7x"‘!~.‘.mr7wr .WWI-‘Q-m.‘ 4mmW4‘tV—,‘y—wwma-v ~

29 November 1973

than not be available in mid-- or late January
anticipate the atudy can start, then we will gladly

Should

what: I
ace-apt:

the 2.5

mtriptylam

of

I; 03-94 tablets and the 10
with matching gumbo.

In either instance.

main

we would 11k!»

to

drug and 200 units of placebo.

mg

but

tablets of

100 unit:- catch

jht

had an manning trip vith ﬁnal: to PhilaI haw
delphia and 10‘; toward to noting him in tale Alto for waits
to California ind Em Orleans.

but

My

”glitch,

.

Binccmly yours,

1m

rm.

11.9.

Professor at Psychiatry

Erich

'

‘Iwmmwnqmpux

..

.

v

‘

"N.

.

�</text>
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A.

,

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-»-

7383-79483
28 Novembor 1973

Robert 3. Robinson. M.D.

Houropharmaoology Suction
A. 1!. Robin: Company

1407-Cumoinsn Drive
Richmond, Virginia 23220
Dear Dr. Robinson:

I havo just rotnrnod from a trip to Europe and boon tovieuod your lotto: regarding tho EKG chanson associatod with
lonporono (Aan2277). I do not know how to interprot the
data prooontod banana. we have bocono ocouotonnd to finding
ouch EKG changes with many of tho anti-psychotic compounds.

your: ago Dr. Itil and I become oonoernod with this quoo~
tion and in a oyotonotic study o‘ thioridnsinn and chlordinso—
potion oolloctod the out. carefully and had then ovaluntod by
two interniuto. Wu worn inpronand that the EEG ohongos induced
by thioridanino wore significantly groator than those induced
by chlozdiaxopoxido. In a oooond study. patients receiving
fluphonozino. thiothixono. and haloporidol wore examined for
EKG offoots.
In this study. the group of patients had favor
EKG changes than the patients who had rocoivod thioridnxino.
Sinco than I have followod the literature carofnlly and note
tho studios of Ban and Lebanon, Gallant. and Simpson. Each
of that: author: has indiontod that tho EKG changoo following
thioridnnino worn much groatot than othor anti-psychotic dross.
Bonn

it

When looperono cons: to Phase III touting,
tight be
odvioablo for you to connider a direct comparison of its cardio»

vascular affects with tbioridasino and one other anti~poyohotio
compound.

with razord to out own work. our doses are much smaller

and we

anticipate

no

direct outdio-vooculnr difficulty. I
this to my attention.

thank you, however, for bringing

-1-

�,WW-‘Yq‘
'7

..

‘

E. E. Robinson. K.D.

28 Havanbnt 1973

*Zw

Rt have continnad our doaa~£1nd1ns studio: and
now
looking with stutter detail at ch. EEG tad behavioralarteffects
of 3 and 6 as domes.
My

bust regards.
Sinaotcly yours,
Max

rink,

H.D.

Professor of rlychiutry

MF/cts

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7353~79OSB
28 Rovenbet 1973
C. James

Klett.

Chief, Central

Ph.D.

RP

Research Laboratory

endeooperetive Studies Program Support Center
Veterene Aduiniettetion Hospital
Petty Point, Maryland 21902
Re:

‘73:!"

&lt;

Gel/151$, 11/23/73

Beer Jim:
«I

"WW-“1

‘me.a'-p:~

—

.mnr

I received your letter

on Hocdey describing the agenda

for the Rev Orlecne meeting. I had diecueeed with Dr. Swanson
his participation at the eeeting, and he is prepared to pet~
tioipate in-the eeeeione end to provide dete from our project.
I

am

unable to attend the eeesion en

at the University on
Orleans until niddey

schedule.

it 18 not
on Toeedey with the

Monday and

we

have a

site visit

tea:ib1e.to reach
prevailing flight

ﬂew

ea pustled by one queetioo which you may be able to
At the meeting in Denver. the question
of the examination of EEG records we: raised. Coneidetins
the limited availability of facilities capable of quantifying
Inch detc, I offered to monitor each a study and to mike the
facilities at Stony Brook eveilehle. I hove written to the
investigators. discussed the propoeele with Bra. Cantor end
Ling. end proposed on two occasions both the budget and the
first phase of such e project. I have received e tape from
Dr. Lins'e cowworker.‘Dt. Barbara Brown. and have reported to
them thet their equipment in fully ooupetible with our system.
1

raise et the meeting.

-

&lt;

vva

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rv.r~r1—'1.'-

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However, since I have not received any official notice
togetaina the statue of these proposals. perhaps it would be
appropriate for either the Executive Committee, the Operation:

�cumin“.
nnd

or Dru. Rum and Cantor to walnut: tbs
proud. some «anion rant-ding ch. proposal.

amazin-

811:“:on years,
rink, 11.1).
trot-«nor a! Payehutry
Hut

urinals
ca: 311th Ling,

14.1).

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                    <text>..
.p

Annammhwwu

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7333~78953
28 Hovuﬂbcr 1973
Dr. Lyle K.

Hillcr

Sankara Pannsilvania Psychiatric
Philadalphia. Ponnnylvania 19129

Institute

Dear Lyla:

I want to thank you for spending so much tin. with Rank
:nd myaclf yesterddy. I found the V131: valuubla in helping
us to undaratand ch: studies which you havm dun: during the
past

few

years.

I read the draft of the taper: of the atudino of acru a~10
1: uttnizhtlorward and have two
on ch: way home. I think
ouggcctionl. 0n the batten of Pan: 1, max: to the lane 1135,
should rnad ACTK 5~10 rathct than kCTH 1~10; and on Eng. 3 ch.
mathod of Experiment 2 could be clearer
tho ward "intra—
venous” were added nonuvhqru in thc mathod.

it

it

Conaidnring the nuﬁbar of variables which havs been teatad,
Benton taut might
have occurred by chancn? In 1: not this 1::un-«and, perhaps, aa
undarstanding of how it cana about—~that should be ch. focus of
a ouccaading study?

is it not poaaibln that ab. diffuroneu in ch.

A331n.

Dr‘cory

my

thanks for the Opportunity to

viait

your 1ab~

o

Sinceruly yours.
Fink, M.D.
Professor of Psychiatry

Max

HP/cia

�</text>
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                    <text>..
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28 Hovuﬂbcr 1973
Dr. Lyle K.

Hillcr

Sankara Pannsilvania Psychiatric
Philadalphia. Ponnnylvania 19129

Institute

Dear Lyla:

I want to thank you for spending so much tin. with Rank
:nd myaclf yesterddy. I found the V131: valuubla in helping
us to undaratand ch: studies which you havm dun: during the
past

few

years.

I read the draft of the taper: of the atudino of acru a~10
1: uttnizhtlorward and have two
on ch: way home. I think
ouggcctionl. 0n the batten of Pan: 1, max: to the lane 1135,
should rnad ACTK 5~10 rathct than kCTH 1~10; and on Eng. 3 ch.
mathod of Experiment 2 could be clearer
tho ward "intra—
venous” were added nonuvhqru in thc mathod.

it

it

Conaidnring the nuﬁbar of variables which havs been teatad,
Benton taut might
have occurred by chancn? In 1: not this 1::un-«and, perhaps, aa
undarstanding of how it cana about—~that should be ch. focus of
a ouccaading study?

is it not poaaibln that ab. diffuroneu in ch.

A331n.

Dr‘cory

my

thanks for the Opportunity to

viait

your 1ab~

o

Sinceruly yours.
Fink, M.D.
Professor of Psychiatry

Max

HP/cia

�</text>
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                    <text>WW“ ”r"

w.

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m.

- -'

""I-xmm‘v'“

auwwnmmmamvzmwr‘wm

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Mr ‘r'r

«Tr .mrv unsavrw

; -~-~-‘-

r7: 'vwvv- .‘gw—wr“?ﬂ'g w". “WW9”.

”TY“

73$B~79ZSB

28 November 1973

Bernd Saletu, M.D.

Missouri Institute of Psychiatry

Street
St. Louis. Missouri
5400 Arsenal

63139

Dear Dr. Salctu:
which

thanks for sanding as can. of your rocnnt
found most interacting and halpful.
have
I

my

concerned with aha and cvonts
occurring in Missouri. I crux: that it will be possible for
Dr. Itil to continue his prograa in Raw York, and I hope :htt
you will find the occasion to visit me and him when next you
come to New York.
As

y‘wmmw

mam

mu

I

reprints,

I

you must know,

am

am mndh

writing also to ask that

recoré from the

How

you change
Yerk undical Collsaa to:

my

address of

mv

Departuant of Psychiatry

school of

r—uwrw.mw

Health Sciences Ccntar
S.U.N.Y. at stony Brook
Stony stock, New York 11790.

,

”renew-Mum:

Mn§1c1n¢

My

...

best razardn to your wife.
Sincerely yours.

11

Var/VHWW

Max

A

W

w-wx.mwvvxw~mn~gmn~u

—-

"v

Fink,

M.D.

rrofausor of Psychiatry

cr-w-vwm-as-u-w-«ww

Mfleis

3.5....

. . .3

�</text>
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m...

7385~78888

28 Havonbar 1973

H E H O R A E

16

:

n

U M

ﬂarriat Chriltuan. nouearch Administration
Pink. H.D., Profonsot of Psychiatry

from:

Max

Subjact:

intuit for

Permian Truval

W;

w

.W-v-m-wrr

mug—m

m-vwmmv-v‘lm'

”5”,...—

mu".

mmﬁv-ﬁ

WW5:-

—'ij'

ivy-'7.

-:

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wwwv

Jami-”F7”

l

Encloaaﬁ in copy a! the capy of thc Intent sent an
October 15 and approved by Earhart whiningnr an behalf of
the Gradusta School.
Mrlcis

ﬁnal.

�</text>
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                    <text>«'1

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WWW!

26 Hovunber 1973

Convutar Dcsign Corporation
12401 Olynpic Boulavntd
Lou basal... Calitornta 9006‘
Gunnlcnan:

I unuld npproeiutn a danctipeion
Statistician. which I

Conpncorp Micro

rcccnt ilauc of Sciuan.

nnd 921cc 11.:
saw advort£a¢d

for eh:
in a

Thank you.

Sinccrcly yearn.
Fink. B.D.
Ptofcscor of Payahiatry

Max

311:1:

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                    <text>rm“
f

7383~787SB
26 ﬁavaubcr 1973

subtcription Dupartunnt
Internatiannl Coancil on

Aleohol and Addiction.
Cane Postal: 1‘0
1001 Launannc
SHITZIRLARD

in:

Change of Address

which you

nail your publica»

ﬁcntlanan:

Plain. chtnsa the adds... to

tion to as

addruss:

from

th- uddrosn nttadhad bolav to the following

9%.

as: I!!!

DEPARTMENT OF PSYCHIATII
ICHOOL
HIBICINE
HEAETH SCIENCES CRETE!

0!

8.9.N.Y. AI $10!? 3390K
810“! BROOK. NEH YORK 11790

0.8.A.
Thank you.

Sinatraly,
Ha: Fink. E.D.
Profculor of Psychiatry

Mllcts

�</text>
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                    <text>‘m\--,-vrav-rm'

.

.n [nu-n 1r,

J." _.”,,,N(W.W,.m.,.,_..

»

.ﬁrnwww.

W_«‘.‘,;A,.;.‘u,mm,...d

,sz: qlxmw w-rmwrm-v—uva wwj‘mnnww'ch'm mv~

-

.

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1

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Ir

,.__...v

7383~78233

7
W

v:

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.

.

26 Eavnmbor 1973
.Wuummavwm.wum

Dr. Alan Ramsay

Cantor for Studies of

W

-nr‘u,'rw‘-x

emu-w.

mow-7

&lt;

2;

Hg.

—1.,.V1»—rﬁdyl-.'Ww

r&lt;.v~q-’”r,'6.l

In

.~

&lt;v“

'1'?

“Fm"vm

nanny-q-

Rarcotico and Drug Abusa

Estional Insticuca of
5600 Fisher’s Lane

Muncgl H¢alth

Rockvilla. Maryland 20852

Dear Dr. Ramsey:

Enclosed is t dppy of tha IND #10095. which was apora~
tioaal for our study of naltraxona.
havu alrngdy answtrud tho questiana on Page 1 and will,
within 2h: suidolinas of our study. make every effort to abidby the suggestions on Page 2.
Wt

request an initisl supply of nnltrexonc,hydrochlor1dc
syrup of appraxinataly 1.5 grams, which will nxgnw us to treat
ftvu patiantn for 30 days. with an avatage dese of 100 mg pa:
day.
we

“ﬂaw-m

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF/cia

Baal.

w

-

:x-

----

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av

u.

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»

.

x“

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'r.“

�</text>
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                  <elementText elementTextId="103814">
                    <text>,, "w

Mm",

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V

“.15... ‘3wmwmm3v-yh-y‘nww.h”7; .m .._. v

.fiwrvyn—rm—J-nnm

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7383~78083

19 Huvamber

1973

wry

'
:0

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.

M B H

0

R A

H D U H

To:

Hr. Jurgnn Krnuﬁc. Associate Ditcctor of Personnal

From :

Max

Subject:

Tuition Waiver for Peta:

Fink. M.D., Profnsoor
M.

Irwin, Spring 197k

Encloscd plans. find the Tuition Haivnr form for Pater
Irwin. Mr. Irwin in ruspansiblo for extannive data manly...
gauorncoi by our ongoing psychiatric cvuluations. 30 use:

facilities on campus for thi: work, and he £ta~
it unca-sary to modify programs and sclcet up.
propriata ctatistical procuduxcn. His atudics in computer

cha computer

quantly find.

at. ditcetly rclated to his work in this departmant
will unable him to pattern his dutica in a morn sophisti~

sciences
and

cared Ind preciac manner.
Your prompt

MF/cis

Encl.

attention in this mattcr will

bu apvreciatcd.

,

�</text>
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                    <text>,

.

w ......
.. ..7..wywrm.ra—__....,—,\.w.-.‘;(._.q___.wv_

w‘v—y...-\.._

“w..." ,v .v.

“ﬂ. “ ..

-,‘,,..V_.r_v_.__..._,_.n~V—-v

_. -. WV- ‘r-

w.

MW."

‘

h. ....."._..

,

n“

_.,,

my," ..

-nm—

www.m-p

‘Iurw'H-I'WW-

wv&gt;1—-"r.‘w

7BSB~77583

'4ruwwn’1

'y"wﬂ4"5"'-WJW‘A'&gt;'

16 ﬁavuﬂbor 1973
"Harv

I
I"

r
3“"

,

'.I""T‘r'

W

vuau rum.

3.».

Alan Corporation
950 Past M111 Enid

Pale Alto. Ctlifornin

9&amp;304

Dear Virgil:

llplln to

visit my

son, a graduate laudtnt in the antrt~
at ananford University. on Monday. Dgcudber 3.
I will Eek. tha libatty of calling your office in the morning
in the hope that it would by possible for an to 3.: coauther
for a chat sous tins ﬁurins Eh. day.

man: of Ecology

‘I‘.

My

‘mg-u.

has: rugsxaa,
Stnanrely yaurs.
Max

Fink.

“.9.

Profcssor of Paychiacry

MF/cin

-m

i

am,

v

.._.

,

-77

�</text>
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                    <text>73619-4 70A?

16

Milton Gambian.
V.A. Boopital

Hoveﬁbor 1973

24.1}.

Sepulvcda, California 91363

Re:

Dear H112:

665/116. 10/26/73

Thank you for your daacription of the Paul Book Award.
baliove
the paragraph apall out an approach which is comI
nondahla and which I will auppott at the forthcoming Council
mung.- shots“ it b. poaaiblo, I would ha grateful if you
would attend the Council meeting so that this morondua can
be mda a nutter of Association rooorday
Many

thanka

for

your recommendation.

Sincerely youra ,
Max

PIP/(:13

Fink,

14.1).

�</text>
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                <text>Correspondence to: Hollister, Leo</text>
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              <elementText elementTextId="58032">
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            <name>Source</name>
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              <elementText elementTextId="58033">
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                <elementTextContainer>
                  <elementText elementTextId="103816">
                    <text>..‘

”My“,

(r
.

”aw.“

V

V

u“

w.»

w. -....»_.w..——..t_wwv...r.—.../......—.,»

ur.“lr-~‘an!~‘.v‘v&gt;vn .0.

mu

7

,.

-

. Hay—rm“ awn—"q... .,‘,,

v...“

_

v

7333-77653
16 Rovoubor 1973

Leo

V.A.

Kolliotor,
Hospital

H.D.

Palo Alto, California 9&amp;304

Door Leo:

I box. just roturnod from a visit to Professor Stefania
ot the University of Athens and hero roviowod with him the
data of our collaborative study, "Chronic Hoohish Users in
Greece." This stuoy hos boon in progress for almost three
our presentation of data to the
years. and an hove limited ACE?
ana
CIR? in Copenhagen
mootinan. I bolievo the data
the

demonstratos some of tho hazards of loog~torm hashinh use, in—
cluding the developunnt of tolerance. Protease: Stefania is

interested in prooentina this material at appropriate nootings.
I understand that you are organizing a symposium on drug abuse
for the 197k CIR? mooting in Paris.
Shoal! it ho appropriate, and consistent with your dooizns for the mooting, perhaps you would consider inviting a
presentation of theoo data at that meeting. I holiovo that
Dr. Stefania would want to make tho presentation, which would
b. oo-authored by tom. of tho inmostigotors from the United
Status ané Athens.

,2

,

My

.4

”mm

boot regards.
Sincerely yours,

no,“

,

mar“.

”I;

piﬁk, Nob.
Proton-or of Poychiatry

uwwrﬁwwq.rﬁwn—r~.u

MF/cia

co:

C.

Stefania

5. Stars

�</text>
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            <elementTextContainer>
              <elementText elementTextId="58042">
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any-ya."

or
n

73AP~767AP

'wwmm-W‘

-

-

NW?

16 Rovodbot 1973

‘W-xr‘

'm‘.

(ﬁn-m»

Jonathan 0. Coin, M.D., Secretary
Anorioan Psychopathologicol Aaaociation, Inc.
Tomplo

Univoraity

Philadelphia, Pennsylvania 19122
'W‘W'WMMW

Baa: Jon:
Tho minutes are ooaantially correct. Since Lowrance Kulia
has died. I have delotol our raconmandation from tho paragraph
on Page 1.

“MEIER"?

Wm

1

Wmm’m’

I have

aakod Fritz Froihon to that: and Joe Zubin and Sam
be
on the Nominating Committaa for 197&amp;. This amendto
ho
addad to tho minutes of Octobar 15. I agree that
uoot might
both Milt Grocnblatt and Mt. Goollnor bo invitad to tho March 6
Council looting. Invitations to Spitacz and Freihan also would
be appropriate.
Guaa

I am also enclosing a copy of a letter that I hava received
from aux: Grenoblatt following our diacuoaion of tho Roch award.
beliovo the latter to self—explanatory and supports tho Com~

Inittaa'a
‘7‘»?

.ieuzwrmﬂwmmﬂwwmm

rocounandation.

Thank you for your help with tho ACNP invitation. I was
able to clear tho invitation for Dr. Van Riozon with Dick on
tho balls that Van Elston to a Iotaisn pharmacologiot. I trout
you will havo a chance to coat his in California. Ho hawo a
date with Lyla Hillar for Novoﬁbor 27.

Sinearely yours,
:4"

ﬁsh:

Hhx

n—xmra

H
95“

at
77-22).?

...v.

ﬁllets

Ennis.

Fink, H.D.

�</text>
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                  <elementText elementTextId="106812">
                    <text>w. .VVv—vr-

- .

a

.w'

,-

_,_ awr&lt; n .-..,..__-..-.-—w..—..-~v._...

.—

, ~...v.....r.....-,_.,— Hwy“. , rm.
.

.

Y

N..- ..

,

w

r.

"m...“w

.u.

Vuﬂq..w.

.,, V, o.

73S3—779SB

16 Rovambcr 1973

Barrett Booville,

M.D.

Division of Nourophnrnacolozy
Food and Drug Administration
5600

Fisher's

Lana

Rookvillo. Maryland 20852
no:
Door Dr.

Haltroxono IRE

Scoville:

I

on writing 13 response to a tolcphouo call from Do. Alon
of tho Rational Instituto 0! Mental anlth. who indi—
cated thnt chore night b. noun disuatisfaction with our IHD
submission for tho uvaluation of nalcroxnno. Dr. Ramsey raised
a samba: of questions. and in the lbocnco 0! clear inquirioa
from your offica but anticipating that than. quootions are
sermons, on at. submitting the following addendo to our sdb«
miosioa of Sopteubor 1‘, 1973.
Romany

1.

Eviﬂcnco of not of opiates for a minimum period
of on. your and at loos: two prior attempts at
discontinuation of drug non will b: proraquinitaa
to adoinatoo to tho program.

Incronanto will follow the

latest information

available. which at prunout ouggonto the ottoty
of 20 a; incromnnts to 100 us 9:: day.
other nnrooaic antagonist will be used as a
control.

3.

No

4.

A

copy of the cousin: form now

in nos 1: attaohed.

“7,-

�v...,.A

u“«r&lt;

w..-

w-u-vru

,-

'I",'

-—.-u-~-n&lt;‘..m.

”1-,...

_, nv- ...... u—m‘ luv—“n... -1...

B¢rruet Scavillo, H.D.
5.

6.

~2-

“w“...w—rr'rnmq.‘

,7

n-

.

,

,

‘

.

16 Hovulbar 1973

This project was approvhd by two

institu~

cional caviar enunittcas. that of the V33
Rorthport, datad June 11. 1973, and the
003138 of 5.U.R.Y. at stony Brook.

urinalysis are cerucnnd in all patient. on
an irregular basis. averaging twica a nick

during tho

first

two months of «valuation

and trcscnuat and weakly
7.

,,,_ .-~-

we

thereafter.

are aware of no svidcnce rcquirina a

op¢~

cial aphthalnolasical attainaaion eithar

be~

fora, during, or littr drug trial. Should
thin ha mandated by the FDA, wt tequnst the
Justitiaation for such unndatc bu suba¢ttod,
for eumpllanca with thin suggestion is Orv

pcnsive and difﬁicult.

Sincerely yours.
Mu Fink,

Hob:

rrofosaor of Psychiatry

HF/cin

Encl.

.

�</text>
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            <elementTextContainer>
              <elementText elementTextId="58062">
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          <element elementId="48">
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                    <text>73AP~771AP

16 November 1973

Joseph Zubin. Ph.D.
Chief of Psychiatric Reeearch (Biometrics)
State of How York Department of Mental Hygiene
772 West 168 Street
new York. New York 10032

Dear Joe:

I

am

delighted that the voluna Contemporary Sexual Behavior

in in such demand. Your optimism in reprinting 2000 additional
copies is commondeble and. onee egein. I think your vision has

been substantiated.

I called Milt Greenblatt and was satisfied that the Com~
mittee had made an appropriate recomnendation with regard to
Philip May. A copy of Milt's note to we is enclosed, and I
believe that the View expreeeed in this letter abould be made
a aetter of APPA record. I plan to raise this in the discus—
sion at the next Council-aeeting.
Again.

voluae.

my

congratulations on the success of the "eex"
Sincerely yours.
M“ Fink,

MF/cie

he}. 0

Md).

�</text>
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                    <text>7383~773$E
16 November 1973

Dr. Karl Pribram
Departs-at of Psychology

Stantord Univoroity
Palo Alto, Colilornio

9&amp;305

Door Karl:

ins.

It was kind of you to not aside soon time on Tuosday uoru~
Doooubor 4, at 9:00 a.u. for Dr. Honk Von Rioaon ond lynolf.
I

hovo knowo

9:.

Van

Elston for three years.

He

in Chiof

Photonoologist in the soiautifio Dovolopmtnt Group of H.V.
Organou in Holland. This company has boon intoroatod in hor—
monoo for unto thou 56 yolro. Undo: the stimulation of Pro»
tensor David De Wind of the Univoroicy of Uttooht, Dr. Van
Riosco and his oo~workoxu havo otudiod the offoots of polypoptidos on brain function in o variety of conditioning pora~
dials. They how: noted that loan of tho ooptidos 30C. to prov
coco tho animal from unwary loos oocoaionod by coz~ or gluon
trioallywinduood ooiauroo.
Dr. Van Bianca in attending tho Aﬁﬂ? ﬂoating: in California.
in intorootod in mooring you to discuss soon thaorociool quoo«
ciao: conoorning nnmory and brain function sad the possible signiliounoo of hormonal influonooo. no specifically aokod to woo:
you on wall as Jim Koﬂough. Ho will ho visiting Jim on Friday
He

and

2:3'Saturday.
I am pleased to oocoupany Dr. Von Rioxen. as this will give
no tho opportunity to visit the Stnnford campus, where my son
ontollod on a stoduoto student in zoology in Soptonbot. Tito
will be ay first oooaoion to 388 hi: and to Vinit-hio dopattmont.
Should he wish it, I may rat: the liborty of bringing him along,

as ho opporoncly ottoodod ono of your looturoo rooontly and wrote
no of his favorahlo impressions.
Thanks again

for letting said. the timo.
‘

Sinooroly yours.
Flak, 3.9.
Professor of Psychiatry

Max

Mrlcio

�</text>
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                    <text>7383*778AP
16 November 1973

J.

R.

Wittenborn. Fh.D., Prasidont

American College of Heuropsyohopharmacalogy

Intcrdinciplinary Research Center

Rutgers Univuraity
Brunswick, Row Jersey 08903

How

Dear Dick:

First, I want to thank you for your cooperation in raw
solving the issue of my invitation to Dr. Bonk Van Riozcn.
I hnvu road you: memorandum of Novanbar 6, and I an
writing to respond to this. The issue» strike on: the
bylaws and present policies of the fellowship; and the nnnd
v~ns pictured by Councilw-for additional inconn.

.w

-

-

TJLW“§IU"H’"'W‘WW

Vmﬁt

".va

'ijﬁl'".

7’”r:’w'

In the early yaars of the ACHP, when it was decided to
hoop the wasting: small. tho 3ellowa votod to limit the nun—
ber of nodbers. and in snooooding your: rantrictad the invi~
cation of sonata to one per Follow. I cannot recall, and in
checking the bylaws cannot find, any stipulation as to who
may be invited. The assumption has always boon that the Pal“
low inviting a goon: would do so for the purpose of expanding
the participation in tho activitioa at the ousting. For cx~
topic. I havu invited co~workorn as sonata when I thought that
'ihayocoold contribute to the sessions or when I thought it
would help thoit education. I have also invited proopactivo
numbers. and in the past your: invited foreign collaborating
aoiqntists because I have vinhcd to encourage a broads: pnt~
ticipntion by the Fellows and laboratotios not represented
in this country. Indeed. Torah Itil, Martin ﬁsts. and I have
carriad this mission to for that no have invited 1 number of

toroixn scientists who how: no affiliation in this country
to participato in on‘gghhg§_nnoting nan: month.

�J.

R. Wittenbotg_

~2¢

'16 Novomber 1973

In this regard, I boliovo it is an undue assumption of
authority for the ﬁectotary, the Pro-ident, or even the Coun~
oil to rejoct an invitation extendod by 3 Follow. whether
Follows should or should not invite snout: to tho 1974 matting
could be toilod next month. If the docioion is made that
sonata are to be invited, it is clearly oath FelloWéo prth
logo to invito whomnvot he planets. and i would hope the Fo1~
laws would not dnlogoto a voto pout: to any officer or to
Council, but would trust tho good judgnont of each Follow.

issue, that of the need of tho Ann? for ad—
ditional funds, is one that should bu diocualed by the Council
and tho followohip next month. I think it is donooning for tho
ACE? to not a quota or levy a tax on industry. should tho ans?
really nood funds for niooions that are in the public interact,
a description of the miouion, a call to the fﬁllowohip with a
oonourroot latter cont through the followohip to indultry,
would probably bring a voluntary reopens. consistent with the
on. to Which the funds would be out. A: it is now, neither
the fellowship not industry has been presented with a clan:
otatoment as to how the funds are Spout. True, there is a
financial report at oath ﬂoating, but this is gloosod over.
Indeed! my tooollection is that the AER? has almost $50,000
iniita trouury. (At the lat nation, I won stmek by the
oboorvntion that tho ACE? was tho secondwrichest organisation
to which I bolong.)
In driving to work yontorday warning, I listened to o
toplay of the Sonata Watergate hanrings. in which tho.Prosi—
dent of Anorioan Airlines indicated the prostate that Mr.
Hixon's lawyer! placed on induotty. Rofleoting on his a:—
ooeintos sad thoir ottionn. I felt those to be immoral, if
not illogol. To what extent would a policy of a molti~thou~
sand-dollar tutti! {or industry to participate in on odocnw
tionol «noting such as out: be tonsiderod of borderlino moth
The oooond

._

..

.
.

.‘.,.,.,.

{“1"

o

,W-‘,._.Hlm.um.

A...

..

2'11""

ality?
I an

to discuss tho policy of abstaing high moor
berohip foe: to 0.8. industry rootstontntivoo. I should like

the Councilla vicwo.to be discusood by tho fellowship with the
viaw that the policy be changed. I holiove that the ASH? will
be on titan: othical and fionocial grounds it participation in
the auctions is separated from the inane: of fund raising add
expenditures.
.

Sincerely yours,

.""

'-

Wluixnwrr:w=rvx’v‘r

Max

';

rink.

M.D.

Protoaoor of Payohintry

V"

.pz‘mwwvw

pnoporod

Hr/tis

�</text>
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                    <text>A.

"W"...

733B~77633

w:

—

16 November 1973
WW7-\I-

‘
"'1"

7—.-

.

Leo

w-wwuww

Hollister,

H.D.

Hospital
Palo Alto, California 95304

V.A.

mum:

Dear Leo:

‘

I have just tatutnad tram a visit ta Profuusar Stefania
at the University of Athens and have revieuud with him the

&lt;-

'
-V-

wrﬂ'aF'W‘ﬂ‘

‘4

Wynn-'3‘:

"‘HJH

-

data of our collaborative study, ”Chronic ﬂanhish Users in
Greece." This study has bean in proztuta for almost thtae
yaars. and we have limited cur presentation of data to tha
CIR? in Copenhagen and the ACE? meetings. I believe the data
demonattates some of the bizardu of long~term hashiah use, luv
eluding the development of tolornneo. Professor Stefania is
interacted in presenting this material at appropriate meetings.
I understand that you are organizing a symposium on drug abuse
for the 1974 CIKP meeting in Earis.
Shoal! 1: ha appropriate, ané consiatant with your da—
sizns for the meeting. perhaps you would consider inviting a
preaantation of these data at that meeting. I believe that
Dr. stafanis would want to make the preacutation. whieh would
be co~authored by son. of the investigators from the United
States and Athcna.

w

-.

«2m,mqv&gt;m,-.wn

my

best tcaurda,
Sinceraly yours,

gar.

’
w

Mia:

unk, mu.

ProietnOt of Psychiatry
MF/cia

cc: 0. Stat-nia
5.

Start

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                    <text>7383—777AP

16 Novambcr 1973

Alberto DiMaocio, Ph.D.
Boston State Hospital
591 Horton Bttcot

Boston, Massachusetts 02125

Dear A1:

After I rcccived your

letter of

Octobor 2k indicating that

"wt cannot extend your invitation to Dr. Honk Van Riorcn.” I
called Jon Cole and than Dick Wittonborn to discuss tho content
of your letter. You must be aware that I became concerned about
two ocpctcte issues: first, whether the Secretary of the ACE?
or the Council of the ACNP have the privilege of rejecting an
icvitction by a Fellow and, second, the manna: in which you

notified no.
As

to the accond point, I understand you called my officc,
it was to discuss this mattcr with no. I trust

and perhaps

wuwutMrmwm

I havc road the Bylaws of the Association as well as the

memorandum of August 8. 1973. Nowhorc in the Bylaws nor in tho
August 8 monorcndum does
state the guidelinco to be used by

it

the Secretariat in rejecting invitations by Fellows. I believe
that your lettcr-cvon on bchclf of Council~~may he an arrosa~
tion of authority which may ho unjustificd. I say "may be" beccucc in youtcrday'u mail I roccivcd a memorandum from Dr. Wit—
tcnborn which may explain the attitude of Council but does not
justify the action of the sucrctcry. I need not remind you
that tho ACE? is fellowship of non intorcatcd in a common goal,
and tho invitation of a goon: usually rcflccta serious consider»
ction and should be givcn unusual «tight by the Fellow: and cc~

:

by tho sccrctcry. who. sitar all, acts to curve the
Fellowship. I undarstand that thorc will bc an opportunity to
discuss the question of inwitod guests at tho forthcoming coating.
and I intcnd to participate in that discussion.

pccially

Sincerely yours,
Fink. M.D.
Professor of Paychictry

Max

MF/cis

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                    <text>-w. a?

«J'vwc‘ncmn'mu—r—"v‘ ~--—u~w

—-

rum.“-

.‘.m

,

y

I&gt;&gt;vw’w ‘m— w.

v1.7..‘_w.,.,_.w.-. .

,w v.7- ,.

.. .

;

.

. ”.4“

,_ ..‘.....».,-.w

w... .v, ‘7',“ V...”

7333—77283
16 Hovnmbar 1973

subscription Bapatcnnut
Coggrohcnsive Pszchiatgz
111 Fifth Arcana
Haw Turk, ﬂew York 10003
Re:

Chang: of Addtaas

thtlcnmnzl
Plants change the addrtsa at which I racotva nggrnhansive

Puzchiatgz to:

Dapartmcnt of Psychiatry
Health Sciuncol Canter
3.3.R.Y. at stony Btook
stony Brook. 3.!. 11790.
Thank you.

Sinnernly yours,
Max

Fink, H.D.

Pratasncr of Psychiatry

Hr/cin

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                    <text>73AP~768AP
15 Novunbar 1973

Donald

Elain,

M.D.. Troasurar

Annrican Psychoyathological Association, Inc.

Htllsida 30:91:31
Glen Oaks. new

Yomk

11004

Dear Don:

It 1: tr“. that one can buy and 3011 shnren of the thnan
Corporttion at thin 13 a elooadacné invescncn: trust-1t has
a limited number at churns outstanding which are sold on the
cpun market. Considnrin; tho dcbacla which has oceurrnd this
week, it may be prudoat ta 0.11 p‘rt of the charts now and ins
vast the profits at 8! in Treasury bills or 8.5! in government
bonds 0

I spoha to Mrs. Podrid this afternoon.‘ Sha told as chit
aha knaw of no probluna with the APPA program. Should you find
that. are any probleus, 91...: call no.
..,

Sincurely yours.

rnmruumrm,

"“7“

WV

”4

Max

3:,

m/cis
cc:

Dr.

J. Cole

Fink.

M.D.

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15 ﬁovcmbcr 1973

Raven Frogs, Publisher15 Host 84th

Raw

Saran:

York. K.Y. 10024

thtlnlan:
Plans: send an

A

copy of the following beak:

May. Smith, tné Villnrcal (Edu.),
KAICOIIO AKTABGNISTS (Advaaetn 1n Biochalical

aruudc. Hattin.

&gt;

rsychopharnaaolagy 8).

W's-15""!

vv-prv

check to: $22.50 (eh. cttalogua print) is unclocod.
sand this book to an at the above nddrons.

A
"Viv"

Please

'.T“r‘v‘wy.rrm

Thank you.

stncaraly yours,

It’lwﬁvrvm‘

wwfrymi

HI! ﬂak, HOD.
Protester of Psychiatry

“mam“.

ywm‘

‘
1

”Mimi-”L

MP/cis

�</text>
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w". .mv. ,_ w.“ ”m.

7333~76553

15 Navamber 1973

F. A. Davis Co.

1915 Arch Streak

Ph11¢dclph1a, Pa. 19103

Att.: Order anartuant
Gontlenon:

I

would

like the ordcr the following book:

P. K. Widnln (Ed.),

0!

which

GOODALB’s INTERPRETAIIOH

LﬁBORAIUI! TEST!

(7th 84.). 1973.

I understand you publiﬁh. A check for $12.50 13 onPlant. son&amp; the book to a. at uh: abova address.

closed.

Thank you.'

Sinccrnly yours,
Max

Pink. H.D.

yrofassar of Paydhiatry
H?/cis
Encl.

r“

�</text>
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                    <text>wmlw‘mwm-‘me.vywrwﬂ,

..,~.,.._-V......,_..

V.r..,“,l___...._.w
V

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.

.n -w “w“. ﬁw ”ﬂaw"?

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7333~76653

15 uevuﬁbcr 1973
/
..

.
Yr".

m...»

n“,1

q

‘ﬁv‘v-rvv

Charla.

C. Thomas.

Publisher

301-27 East Laurcnca Evan»:

Springfield. Illinois

6271?

.&lt;y—-Vu'm"

Act.: Oran: Dupartnanc

4

Guntlumnn:
,,,...‘V,‘._.‘«..,T,w.v.w~.mv-.

I

would

likn to otdor the following book:

L. E.

Holltntcx.

DEERE,

1973,

CLIHIGLL

883 OF PSYCHUTHERAPEUTIC

-u‘,...:vn—.;_.wm;r-

which I understand you puhlinh. A check for $6.95
Ylonaa ugnd ch. book ta an at the IhOV! addrcna.

-

3.70;".VNf‘

1: uncle-ad.

Thank you.

F—I’H'W'

alncorely yours.
mxmmn

me

Pink. M.D.
Profassnr of Psychiatry

Mix
wv-xvd'w-lm'

”a...

m...-

.W

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7
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                    <text>7383~76358
Bovunbnr 14. 1973

Riehard P. White. Ph.D.

Profasaor of Pharmaaology
University of Tenness¢u~ﬂadical Units
Callaga of Basic Mbdicai Sciencas
800 Madison Awunue

Hemphia, Tennessee 38103

Dan: Dick:

is the third lattor I hava racaivnd since Labor Day
tuquesting reconmnndations for consume to lead a departmnnt of
Yours

psychiatry.

‘
m-

"’13

mwwm—

(«W‘rwurm

w.”

‘ZF‘S‘!’

rv'xmw-"an-wv

;‘_,,,:W~‘7W"llvwwwrWﬂwn,t‘!'ﬂ"-7“'U

0f the man wcrking with an. no can seams sufficicncly can
parianced or mature to accept sudh a rasponaihility tt this tiﬂﬂ.
Of the men with whom I am closuly associated, I knew no on:
who is uncamfortable or unhappy with his present job, with 2h.
axcaptiona af Prafastoru Elect and Itil of tha Univerlity of
Missouri. You may not know that thc Divisian of Mantel Honlnh
of that Statu has prescribed research in paticntn at State in—
stitutions. and both of thug: tin: professors haw: rcuisnnd in
protont. I do not know whethar Dr. lint: has naught: position.
but I do knnw that Frofessor 1:11 in nasatiatins with_Dr. A1130!
Pt¢odnan of the ﬂaw York Radical College. Both of this: man hawt
1nd extensive program: 6! ranalrdh tad havu shown their
ability
as tenchurn.
Good

J!

luck in ynur search.

My

best tqgnrds.
Sincerely yearn.

V
‘

rink. M.D.
Praia-nor of Psychiatry

Max

�</text>
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                    <text>n

w-uwu—MTINaran—wmwpw—nu—

-

~

u

,A

-...

cam-m

4“,..."

”7“. “JV“, .7 ,or,

.1....,..,W.,....,,,, w"
v

.m-v

r

..

..,.

.

-..... ,

n.7,," ‘r 17...“.

..&lt;..

.... , V......v.,._..o..r ,.

._n

73sn~76083
1a Rovonbor 1973

Charla; 0. Rutlodga. Ph.D.
Dopartnont of Yharnnoology
Univotolty of Colorado School of auditing
4300 East 9th Avenue
Denver. Colorado 80220
Boar Dr. Rutlndzo:

I ll planned to submit this letter of recommendation on
bdhalt of Carolyn V. Poiolor. who has worked with on since
Juno. 1972, following her graduation tron Colby Coll-go.
graduated with I major in biology and did eopc~
oially wall. but aha also to on without I specific toouo of
interest. This laboratory is dodtootod to the analysis of
tho changes produoud In tho scalp EEG of man by prolunod and
actlvl poyohonotivn agents. Th. facilition include Grass
polygraphs. FM tap. roootdoro. and a dodicotod IBM 1800 con—
onto: for data rcduction. Hi work with voluntonr waist to
ﬁxtondod obocrvatlon aoaoions.
Candy

Candy

has learnod

how

to interview voluotcoro. obtain a

analyst this quantitativoly aging all of the dot:
tuduction oqulpnont, and to nuunarlso and «walnuts tho data.
In addition to £36, oh. has loornod how to obtain Ilood can»
plan. take blood pressure. ond-noot 1mportant-to maintain
a profounionol attitude with subjects which inaptroo oonfidanco
and their cooperation dospito aioconfort.
fine

EEG,

This work has boon going on in my liberatory since 1959,
and Candy has been one of tho two most outstanding students
thnt I have had. Sho has always mnintalnad hot point, is moot
plea-oat to work with, is enthusiastic and completely roliablo.
.A

,

.
u:

'mm-‘m‘wwbmaruﬂr'fﬁ‘ﬂv

.;;.

Now—r

..

1

�mW—wwmw-Wﬁ.w.n‘wp.ww_.

Dr.

c. 0. Rutloégg

7w w mu“,-

-2-

,, ......,.. ..,.._._

,_

_

WW aw.

.

7—

._._ m. ,_»

V

7.

a... ..

16 Novonbor 1973

Horn 1: not for the fact
on to graduate eduottion.

that I onoourago my antistnnts to
I would rcgrot bar dociuion to
but
I
loava.
an gratifiné that the has seloccod n fins ins
stituuion in which to continua hot graduato studies.

I In ploasod to raconnnnﬂ bar without roaorvation for

go

you: graduate study program and hi»! assurod her tho: I would
b. dolishtod to havo hot toturn to work with no at any ttno.
Sincerely youru.
ﬂax Fink. M.D.

Professo: of Psychiatry

MF/oin

Encl.

�</text>
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                    <text>73SB~762$B
1A

Noveﬁber 1973

Professor Alfrod M. Fruednan
Department-of Psychiatry
Haw York Midical Colltge
Cahen Rnaaarch Building

106th Stroet and Fifth,Awanno

New

-

.
-

York, Raw York 10029

‘.
~v

m.

Baa: Al:

r-v1~,.vW-‘r"-W'1'v

my trip through Europe I had read the daily nnwsu
with
paputt
tropidttion; the wax in ltraal and scandals back
bout. the continued dsvaluation 9! ch. dallar, the 011 crisis.
and so many other horrendous stories seamed to fill the ptgaa.
As I want from Ron: to Istanbul. tha Iribuna currtnd the
story
at your Vilit to Russia. Whan I arrived-1n Athens, I found
tha
ulna story tn tho Athena H g. A: I hive lost tha Ttibuno aun~
nary. I an anclnsins that in tha Haws.

During

“'75

u

"'77,...WWWMV.

”_w,,._v...

‘1‘

‘

(wrr-Tzr

var

.
.

Jan»

r
._
w

._.._,-.,..-T.,._

«m

m-

-

m’l“$"'w'r4

I fnlt proud to be : monks: o! the APA and a number of
yaur staff. for it in rat. in this varlé—«which Icons so disw

houast and when: lenders Iona intcnt on calf—aggrandtsunant~~
to find that on: of my frinuds has apakan out. Thin was put»
titularly true bccanso, during my visits to Istanbul 1nd Athnnn.
I was imprinted by thc autistic: at Dru. Polvnn 0nd Stafaniu,
1nd their co-workors. Innnl 613 and others. that the United
Stntaa might net stand up to the Runnicn thrust. Since thc
Russian: rtptnuant tho principal threat to world peace today,
I an grateful that you and tho Association haw! spokan out
againat the abuts: of power that hnvu batons the hallmark;
of Run-inn thought and action.
My

thank. for your hanacty,
Sincaruly youth,
HI! Fink. ugh.

Professor of Psychiatry

HF/cia

Baal.

�</text>
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                    <text>.77."- ”Mr.

. ,..

,1,

w

.,-...

,.r....,.~mrv-rqq—Wr.m

"WW—“F.“-

"15.

.7”—

,_..

.,-,,.. .,,

_,-r

y.

,—

mdm

...v_7...w.~.__wvn .

.K .

-ﬁw.

7383-75933
1&amp;

Novonbor 1973

J. Roubiaok,

M.D.. D.8c.
3nd
Radical Rosoarch Division
Biological

Exporinontol Thoropoueieo Department
8nnﬁox, Ltd.
Ch-éOOZ

Boole

SWITZERLAKD

Door

Jiri:

Linda and Hichaol join an in thanking you for your many
kindnooooo during our visit to 33:11. Kot only was the visit
can that gave no professional excitounnt, for I an very much
impressed with your laboratory. but the opportunity to see
Basic and a pica. of France and Germany In wall was nos: ox~

consider the visit to the Boole
the high points of our trip.

citing to the children.

Musouu can of

We

If my visit was of coy help in orienting tho lttff at
Sande: to the potontialitien of quantitative EEG analysis.
than I will oonnidor the trip to have been most ouoeoosfol.
I an enclosing a capy of the announoonont of the ACE?
ﬂoating in Decombor. I look forward to oooing you at the

ﬂoating.
My

bout regards to Marcia and to your codworkors.

Sincerely yours,
Fink, M.D.
Profeoaor of Psychiatry

Max

Mir/c1.

Encl.

�</text>
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                    <text>memwmw......W..,.

.w

7

.

______,..___

_.__.W

.V

I

“mm. W

E

E

7358~76153
14 Hovedbor 1973

G. Dolce. Man.

Mtdizinische Porschung/Pharmakologic
E. Metdk
61 Darmstadt

Frankfurter Straﬁo

250

GERMANY

Dun: Dr. Dulce:
;

I ranaivaa a note from Dr. Goldutcin that your trip to
ch: Unitod suntan has been dotcrrtd. I had looknd forward to

your
,

E

E

:

visit in

Havanbct.

I hope that you will have I chance to can. to the 3.5.
the
in
lprins, as Dr. Goldacetn auntiannd. and thus you will
than have tho 00333103 to viii: my laberatory.
my

bus: regards,
Sinantoly yours,
Max

fink.

M.D.

Ftofasaor of Psychiatry

K?/¢1s
ca: Dr. Leonid: Goldntcin

�</text>
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                    <text>7383-76388
Hovqnbor 14, 1973

Richard P. White, Ph.D.

Professor of Pharmacology
university of Tennessee Mbdical Unit:
Collega of again undieal Scianccn

800 Madison Avenue
Memphis, Tannassce 38103

Dad: Dick:
Yours is thn third letter I have rocaived since Labor Day
requcating recommandations for someona ta lead a department of

psychiatry.

Of the man working with an, no on» aeams sufficiently can
parienced or mature to accept such a resyonmibility at this tinn.
0f the man with whom I am cleanly associated, I know no one
who is uncomfortable or unhappy with his present job. with the
exceptions of Profcsnoru Ulntt and 1:11 of thn Uhiveruity of
Miasouri. You may not knaw that the Division of Mantal Euslzh
of that State has proscribed reaoareh in patient: at State ﬂI*
uticutianl. and both of that. fin: profonlorl have resigned in
protoct. I 69 not know uhathar Dr. Ilatt has another position.
but I do know that Profaaaor Itil is nagotiatinz with Dr. Alftad
Freedman of the New York Medical Collage. Both of thus: nan havu
lad axe-naivn program. of reaanrdh and have shown their ability

as catchers.

Good luck

in your search.

By

best regards,
Sincerely yours.
“RE, 1‘!va
m
Ptofclsor a! Plydhintry

HF/cis

‘
‘

,t
‘.‘

I
‘

Ytrwr

.‘mlﬁmlﬁm

-

�</text>
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.v.

._

...~..

-

(—7»

~&lt;—.~'v'a"_

73SB~756$B

13 Hovembor 1973

H. C. B. Danber. M.D., Ph.D.

Pro£cuoor of Psychiatry and Pharmacology

Callas. of

Modicino

Milli: Health Cantor
J.
Univlroity at Florida
H1111:

6:1nsnvillo. Florida

32601

Door Hy:

can to

York, I “locum! tho publications which
paychepharnooology from 1956 to 1967,
for
I felt were important
I am enclosing
of
psychopharnacology.
in
my course
a: part
no
an
v.11
additional
tho
an
of
group nines 1967.
a copy
reprints
when

I

Row

were to focus an I3 principal interact: in psycho~
pharmacology, the davnlopmant‘of quantitattvu EEG methods for
classification of drug: would have to be my principal contribu*
tion catamaran.~ From the voluao. you will no: curly papers
from this point of viaw, and sons of the later raprinto will
.

If I

bring the information

up

to data.

anothot point of View, I have always felt that con—
vulsivc therapy was a complex way of proviﬂina portintcnt bio»
dhaaicnl chanson in the brain for thoir boh:V1aro1 effacts.
2 In oncloaing a ﬂaw raprinto from :3 BOT axpcriuuco, particu~
ltrly tho cholinnraie hypothesis, for those may also bu tale»
van: for a rovicw of poychopharnacoloxy.
From

Finally, the'principtl focus of intoraot in How York has
boon tho duvelopnnnt of narcotic antagonists, and I am enclosing
a xnroxed copy of tho report whioh I pruparoé for the Marijuana
Commission in Soptoubar. 1972. This will 31?: you, I hops. an
overview of
My

mvwc

this spoaialized braaoh of psychopharmacology.

bust regardb.
signeruly yours.

.‘——-

'“W’mﬁt‘rry

:4». Pink,

um.

Professor of Psychiatry

‘mw

Noun

MF/cin

�</text>
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                    <text>731~7S7I
13 ﬁavuﬂbar 1973

Dr. Stephen

Stir.

Bivition of Eutectic

and Drug Abuse

Rational Institute of Mbntnl Raulth

Fiahcr's Lana
Rocivillc, Maryland
5600

20852

as:

H3K42-7ﬂw98

Dcar Stave:

I have retutndd from a visit :0 tha-projact "Study of Chroiic
Kanh1sh Uaaro 1n Grcocn" (33H42—70~98) Ind I am writing to bring
you up to date with tha ptagruos.
As you knaw {run your

visit to

Athqa: 1n Augult. the study

callection at data in the tents experiments
in the early spring and the data were analyzad, both in Athanu
anﬁ Haw York, during the summer. A major pattion of the analysts
warn éonn than Dr. A. Liakos unwind in my laboratory for three
vodka in July. -WHon.hc luft, there wet: some tonidual antlynas,
and these Hath couplotad 1n saptlnber and sent to him.
team coupleteé tha

Beginning in Juan, aubjccts warn induetad into the with~
drawnl study and as of November 1. 12 aubjacts hast completed
thc aix~day observation period. I brought the EEG taplt back
to my laboratory on Hovuubct 12. The study tuna in Athens 1.

q.

nears-w

"yr—rm.

v..-

|

aontinuing with the inéuction of subjnctn in thin withdrawal
study and havn set that: tarsut as font additional nubjects,
{or a projactué total of 16. Thay do not baits?! that they
will be shit to ranch 20, but trait that 16 will provide 315~

niﬂieant data.

There have batn no changat 1n the ntaff in staff at Athens.
Despite aw leaving tha Haw York Mbdicnl 0011.31. my cedworkntl.
DrI. Dornbush. Crown, cud Volavkl, aontinua to contribute to
the analysis of that. data.
You should be Ivar. that except for the prsscntation at
thn 1972 818? nesting in Copcnhagnn and ruviuwu at the 1971 ind
1972 tasting: of the ACHP. this material has not bcan palsunted
or publish-d. In ptrt. this rctltctod a reluctance an tha part
of Professor Stefania and.uya¢1£ to prajudga tha data, and I an
culm-

�wanna—nﬁ— h“. 1—H.“ . Y. n-

Dt. Stqphgg Santa

platted

*2~

thtt wt hurl hnnitated. for

7..»

.

w

r. rum...

Wu“ "ﬂu”.r ”pp“,W—

13 Routnbat 1973

our viaws hams undcrgone

changes during the progras: of this study. Profasuor Stefanis
and I discnlaed at length the matter of practicing this material
and praiinionally wt hnvu decided that we will:
(1) truparc a summary for HIKE to supplement tbs
summarits aﬂbnittnd artliar and submit this
tunnaxy with duplicattn of tha data set as
soon as these ate Ivaiidbla.

balicvc that tbs data land thennalvua to
»approxinata1y six to sight prustatutionl Ind
publications in seicntiﬂic journals. and an
'lre prograssing with the preparation of theta
rcporta.
(3) Concurrent with thane two forms cf data ptao~
entntion.*wa believe that the ruports and mate
extensivn data than is stainarily providtd in
journal articles provide a legitimnte basis for
a significant vulva. on the affects of chronic
hnuhidh use in man, and W! plan to nah: sudh a
presentation. (This is particularly important
since the scientists nothing in the Juanita
study appnnutity adopted the utratuzy of pran—
entina their matarial in the pdblic praoa.
instally with regatta glowing tastimaninls of
the curacy of chronit hadhith use.)

(2)

Wk

I balicva that U! will need 1n attention of time if we
are ta attoapliuh the Idéitiannl {our nubjacta. Analyse tha
withdrawal data. writs thn report: to: publication, ate. I
tn aware that at our last Intting in Juae. you: associnta: «are
insistent that the study he annpiotcd by the and of this your.
Shauid this viuv rennin the official position, we will provide

all of thc data availibla to date, including tho with“
értwal dtta, in whttsvar stats thty any be on Decanbur 31.

you with

“a ptafot, howevat, that you reviaw the used for this ttruinn~
tiou, particularly in vita of the fins wart the Gtaok sciontilta havo dong and thc uniquc nature at tbs withdrawal éata.
Wt would raquost an exttnnion of tin» and will prcpnra a bud—
gattry extinct: should your tamuittuc feel that an extension
is feasible. 1 bcliavc that in eatansian to April 30, 1974.
would providn suffieitnt tint to carry out the final phat: at
this study.

�7.
mun;

mum-guru

.
-

m'm'm"m:m'rmww

H17"

.,.,,

.

.v‘..»mw-.g_\——

_V.W.Wm,

Dr. 3tl$h0n_881ra

.w wm—p

WNW“ .1 q-.ry_mwr,_. m."

m-m_-—.u “.-

13

~3—

.-u.-.~,..,ram—w

ﬁGthber

.m. :V‘erI-M'rww'

1973

Yrofousor Stefania tliICd on. administrativh problem
with mnﬁ~that of ch. duvaluntion of the dollar. At their
prestnt rate at uxpeaditurat, 1 d0 not anticipate that the
davaluation will altar ch. budget cignificnntly.

Sincnrely yours.
Max

en:

E.

J.

Gvadwcll

Fink.

M.D.

«w

.7

.-.—

a

A

v“

7,7 .rmw—

,—

�</text>
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                    <text>w, .07

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wnwr-vrw—w—wv-m-w

thaw'v'ﬁ.

W:

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7383~75488

.

www-gmr..~ru

13 Ravi-bar 1973

rmﬂdjn

5.,
~11.

0;
.

1_’J“V1Iv_

r‘l"’§"'

KB!

a-a'wnuﬁ

wm-wmmnn-r

lullagég

Publicattanu Inacarah Offien
Rational salons. lbundntion
Washington. 9.0. 20550

an
vw

1w;

Gontlanan:
so no

I would appruciato having cepins at the £8? Bullocig unit
at:
Depareunnt of Fuychlntry
School of ﬁadiaiua
Rnalth Scianecl Cantu:
8.3.3.!. at Stony Brook
Stony Brook, Raw York 11790

,
M»

5:,
A

mayﬂxﬁc

r4

1"

x
1W

7-;

:ggrf'r'vr-J"?

Thank you.

sinenruly ynuru.

-',.‘1;'

vzu-rwn

Max

Hiluiu

.-

rink,

M.D.

Pratt‘sor of Ptyahtaery

ywmmmmrlwx'vrmv'

�</text>
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                    <text>731*7581

13 Novambor 1973

HE. Rs Jo “YWCJ-l

Contracting Officer
Contrscts Kansgsnent Branch
Rational Institute of thtal Koslth
5600

Fisher‘s

Lane

Rockvills. Maryland 20352
Ra:

BSM42~7D~98

Dsir Ht. Gradwell:
Encloscd in s oopy of s latter I have none to Dr. Stephen
scorn. reporting progrsss in the study "Chronic Hashish Users
in Graces" (35H 42—70u98). Progress on this study has bean
ontstsndinaly good. with the stooption that tbs timetable which
tho Committee insisted upon in Junc-oanaot to not without totni~
noting the study in an incomplote ttsse. I am, therefore, re~
qussting an axtension to April 30, 1974, and havs outlincd in
my lotto: to Dr. Saar: the tsssons thstsfoto and the
state of
tbs study during my visit to Athens on Novembat 7 through
9.
Should an extsnaion be possible. tho Association will prs~
puts the nsoasssry supporting documonta. Should the Connittos
rocouusnd tsrminstion on Doesﬂbor 31. us will submit s final
taport. oopias of all of tho dots. otc.. according to the oon~

tract .

Should you wish additional infatuation, I suggest you die—
enaa the progress in the study as witnssood by Dr. Stars and
3:. Smith during their visit to Athens in August.

It is a pleasure to work with you, and I trust we can bring
this extraordinarily incarnating study to a satisfactory tomplotion.
‘

sincerely yours,
Max

Hrlcis
Baal.

Fink,

M.D.

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