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                    <text>.v.

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April 9th, 1973

Jenn 81mm, 3m”
Missouri Inititute of Psychiatry.
shoe Arsenal Street.
m6 631”:

5%.

W‘,

Ben-

3m.

have read the paper "Acute Behavioral Effects
of Doxepm, Immine- and mum”. While the
clinical material is quite good, I believe 1:11: EEG
12

alumna

to

with you.
My

come

I have given

to Peter: and
as ”have had a.
it.
some
to
conclusions, I will be in tench

should be updated.
asked him to reviw

As soon

a.

copy

best regards to Susan.
Sinceraly ymn's .

ﬂu: mm, 24.3).
Profassor of Psychiatry
WI 13

.

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6... 5.

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                    <text>7333~61h

April 9th, 1973

ﬁr. Michaal

Box

lhll,

R. Knﬁyp,

Trinity College,

Hartford, Conn. 06106.

Dear mr. Knapp,

It

13

difficult at this point to be sure that I

have an opening this tummar. I vauld like to madt
you. however, and am writing to suggent that ycu get
in touch with Pat and arrangc to visit him. It will
be useful for you ta know what his work has been, and
if it is still of interest to you, arrange to meet as.
I am,usually in New York city on wbdnesdayn. If your
schooling does not pmrmit you to came during the next
few weeks. I will be glad to see you at my home in
Great Neck over a weekend.

.
my

If”

an

‘v-

7-

M‘WY

aincerely yours,

a"

ﬁwﬂwi

:
v7!“

Fink, M.D.
Professor of Psychiatry

Hhx

ﬁ¥l13

«W

�</text>
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                    <text>11'1-‘07-1?“

xx»

Ir’Z’ulﬁ'

~

'grlw

73I~605

April 9th, 1973
Dr. Ehrtin Kata,
Clinieal Eesoareh Branch.
National Institute of th$a1 Health.
5600 Fisher; Lane.

Roekville, Mhrylanﬂ 20352.

Ba: Mﬂlﬁﬁélnﬂﬁ

Dear Murcia,

I am vriting to roqucst an axtonsion withnut
additional funds tar £815561~93 to Deeedhcr 318%, 1973.
The present projnct period and! Mhy 313%. 1973.
An"

1'15““

zxx-wu'ﬁw

m:-

:v»

-.

‘-‘.'W",m"g-‘i'1'2;‘h€

As you knaw, V! have completed.mnst at the clinical
studies under this grant. and during the past raw annths
used seas of thn funds to complete tbs «valuations sud
regatta in support of that progoct. An extension fbr
tho rauninﬁnr at this yam: will permit us to complete
the vurk in accordance with our original dcsign.
Mung

'7‘”

I

W.

thanks.

‘
‘

sincerely ycurs.

megawmgazmrrm

Mnx

Fink,

M.D.

Principal Invustignter

Approved

Thunders 5} Isr321.

Presidant

HF/id

Jr.

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9

‘MWAVWZV‘LW’W‘fqPY

;
‘

.yywvfu:

A

&lt;~,.q.w_...v,v

pm-cmwvmvw

7383~606

April 9th, 1973

Dr. Abba J. Khttin,
Dupartnnnt of Me41e1.no,
Tulsa» University Schnal
1h30 Tulane AV...
E” 0:10.133, hub 703.12.

at thieino,

Dear Abba,

I had a very ploauant time in Raw arleans. and
an lorry to hlVl aissod you. Enelolud is a copy of

my

filing of an

now

A:

umandmnnt

to

IND

8569.

I interpret the rclavant regulutions,

undertake this study.
Good

you may

luak.
Sincerely yours.

Pink. “OD.
m
Professor of Psychiatry
M7713

Enc.

ca. Dr.

K. van Hiczon

�</text>
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                    <text>rm”,

;

TBI~609

April 9th. 1973
Hr. Arnold Cantor,
P.O. Box 325.
Paranoia. 3.1. 10571.
Dear Arnold,

Enclosed is a copy of the inventory of equipmant
of tho Intarnationol Associaoion. an of April 1, 1973.
Ital: 1000-1003 are at tho atria. of the Ansocintion,
39 Arleigh Road; itana 100h~1133 are at the State Uhivnrsity
of How York at Stony Brook; and items llhhullTﬁ are at
the new York Mkdical College (5 East 102nd 8%.). The
items at the state University of Row York include tho
oomyutor installation and most of the technioal oquipmont.

rgo_‘!.$

—.'

Nagy...“

,Wl"!f‘}¢‘

:
”(new

while most of the itous can ho considered ”sol:innured". it would be prudent to obtain covorago against

tire,

wator damage and vandalism for the
1022-1059).

(um

IBM

1800

syttcn

I am also tnolouing abounonta from the New York
Mbdical Collogo describing the transfer of the oqnipmnnt

to tho Association; the relevant chapter: of tho HEW
grant. ndninistrution manual (chapter 1-h10); the grant
award for MR 2&amp;020 which includes $16,500 for renovation
of space far this oqnipnont: and an dbatrnot from

Newsletter (volumo 10, nudbor 2) dated February,
19?3. which nonworo tout quoations regarding the transfer
of equipment. These documents have been revievod by Hr.
Joshua Vogel. our legal noviaor, and it was hidgopinion
that legal title has boon transferred to tho Anabeiation.
and that V! should do all things which would be prudent
for tho maintenance and protection of the oqnipmont.
NIH DEG

Thank you

for your assistance.
sincerely yours.
Max

Fink, H.D.

Encouiive Director

MP/id

co.

Mr. Joanna vogel

Enos.

�</text>
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                    <text>7338-6215

April 9th. 1973
Jonathun 0. Cole, Md). ,

ﬂecretary,

Boston

APPA,

state anpitsl.

"

Ex
.

Beaten, Haas. Galen.

_

\

‘Y

Dear Jonathan,

I mot Dave banner at a. meeting on Wednesday,
and. he asked whtther we had «:11de on a hotel and

the dates for the APPA meeting. I told him that
I thought these would bar deemed ut the Council
heating; but untieipnting that occuien, would it
be possible to have the mbeomittco when the
necessary enquiries?

I note Fritz WWW acceptance at Warship
A: for reimbursement
for travel, I bane" this 1: upmprh‘be, and it
Dan Klein comm. hits ahould bu renamed.
1n

the Pnblieatim Omittoo.

Simarely your: ,
Fink,
m
Profunor of Psychiatry
£4.13.

Hflié

�</text>
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                    <text>,7, M.7-.r.,,.

.

I. ,9...“

.

V. ....

W... .. Vuwmm—r
,_

~ar

Y-

.,

.m-w

unm-w—rwr—z 9m

"MW":

-.'--~'1

"“5""

“WW"

‘ ‘-

"‘~

‘

"‘ "A" ‘7‘"

'

" "“

‘

73I:086EC

April 8, 1973
Mr. Lawrence Erlbaum

V.ﬁ. Winston &amp; Sons
1511 K Street N.W.
Washington, D.C. 20005
Dear Mr. Erlbaum,

Enclosed are a number of items: the corrected versions of
the papers by Fink, DYElie, end Volevko; two new reports (number:
21 and 22) by Kety and MoGeugh; edited pages 1 and 2 of the
paper by Ottoason (01h); end a discussion by Ottoeson to follow
paper number 1 (Fink).

I have made the correction: requested by the editor in red.
Note the comments vith regard to ’leucotomw'.'grend mal'; the desire
to use italics in my report; and a few other suggestions.
At present, there are two reports lacking: an overall summary
(paper 20) and an introduction. I shell do what I cen to get these

to

you

shortly.

Incidentally, I found your editor thorough.
many

m’

v";

thanks.
Sincerely yours,
“‘3’.

":5 ﬂ

Max

my

,.

u;&gt;

v
.

”“7”.”

r'.

.

:

‘(

',.-'

Fink,

-‘

"1':

M.D.

�</text>
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731:08h1

April 7. 1973
Mr. G.C. Kunzman
IBM

59 Maiden Lane

Haw

York City

Dear Mr. Khnzman,

Enclosed

of invoice

is our check in the

amount of 8&amp;8.00

in

paymont

BKBTThT.

Please note that this organization is taxrexempt; the
appropriote records are on file with your organisation.
Sincerely yours.

4?.z,éyn
NIX Pink. “.3.
4

W

�</text>
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                  <elementText elementTextId="103764">
                    <text>.._

,._.,,.,..

V

w.

.,

.7

_.

.

ca,

79......"

a ,,.,

., -.
.u- ., -, “H

,N ,_,
.

.

,

.. . .

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4

en;

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17‘

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.

11"...“

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wmx—r a.

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.-

731:08lﬂr

April 5, 1973
Costaa Stefanie, M.D.
Universety of Athens
Athens , Greece
Dear Costas,
March has passed and despite many communications between
my office and NINE, I believe we are in the same position we

were in a year ago, I am writing to acquaint you with the facts
and to ask your guidance as to what should be done, if anything.
Our summary

report

was

sent at the end of January. Dr.

Snare apparently teed it and asked some questions, which we
answered. He also enquired about the budget, which we answered.
We next heard that the request would be reviewed by
a committee,
and then last week we heard that the committee had given its
qualified approval, with a weak endorsement.

I called the contracting officer to get his advice,
that no further negotiation was possible until he
received a detailed contract proposal from 'progran'. He expected
such a proposal in a few weeks, and then he would consider when
he could get to this negotiation, "there being more than 800
contracts to be negotiated".
When

he answered

I believe the stag! at NIMH are as little interested now
that the only movement will occur near the end of
the year, in June.
as before, and

options: to assume the contract will be
that you will be assured only about June 25;
or to indicate that extension is not requested and plan to
end in June. I hesitate to recommend since either course
may be painful. But I believe you should advise me as to what
is in your best interests, and if possible, I will try to work
with you and NIMH toward that goal.
You have two

—

extended, and

My

best regards.
Sincerely yours,
Max

P.S.

If I fail to

+415“: +0.

Fink,

M.D.

hear from you by mid April, I will allow

“an" .vl‘L--..l.

m7

4h+nvercn+4nm

cuf&lt;LL bYTan

�</text>
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                    <text>Tssnéoh

April 5th.
Mr. Michael R.

19T3

aonnenreiah.

Executivn Dircetor.

Rational Commissien on Mnrihuans and Drug Abuse,
801 19th Street H.W..

Wishington, 0.0. 20006.
Dear Mr. aonnanreich,

I have reeaivnd.your nuaarandun regnrding tha
rastrietion on publication of the report on nnrcotic
antagonists which I Iuhnittca to the Commission.
In thn .1: annthc nine: thgt raport was written,
a number of papcra have appeared vhiah would auguont
that rcport and make it more timnly. If it is still
possible, I would 11kg to sﬁhnit an uycated report. The
uydating would serve prinnipally to ingrovo tho
axility or the docunsnt ‘3 a reference aaurce. It will
not ahange the Commission's conclusions, with which,
incidsntally. I agree.

If it

1: possiblo to

umsnd

the text. please

call my office (arou soda 516, hhh-zhhv) and I will
set Q copy to yum within three days.
Sinscrely yours,

Fink, M.D.
Professor of Psychiatry

Mtx

MF/iJ

�</text>
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                    <text>nib-607

‘pril

W

M6518!!!”

y.

Program Head,

2nd. 1973

HOD. .

Early Clinical Drug Evoluntion Unit.
Psychophamoology Research Branch.
Rational Institute of Mental Health.
5600 Fishers Leno,

nockvillo,

Maryland 20852.

Dear Tom,
Enclosed is a short abstract of the presentation
which I plan to make at the May 25th annual mom meeting.

I think the program is fine. Should it be ponible.
be batter accepted no
following that of David Nargulen. rather than following
the two teohniool, statistical. highly sophisticated report:

I think the presentation vould

of

Mike Free and John

Overall.

Sincerely yours.

Mix Fink, M.D.
Bxetutivu Direotor

m/1.1
’

C

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                    <text>,,

u..—

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a,

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'5- ,

~

7383-598

,

To:

Leonard E. Mniselns, N.D.

FROM:

Mn Fink. km).

SUBJECT:

Canscnt form

I.

The "EEG und Human Psyebaphnrnaaology" protocol
submitted earlicr specified that uﬁbjcetu must be 21 years
of age or oldar. In ﬁhn event tact thcrc is any othar

dnlignntien.
2.

It

pitta.

nceept

this note as a ravinion to indieate
a1

regret that I face once again the
an» English lungungn of thc consent
hgwu aceep¢ea thasa nadificgtionn on the assumption
1. vith

coma

critical suggestions of

turn. I
that the runnindor of tha rbrm mutt: with the critical approval
of the Cummittoo; and I trust that this medific;tion is
tatiarhctory. Vb need not olluv space tbr signature of parant
or guaraian, since

Mllid
ﬁne.

this is not cancntiul.

�</text>
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                    <text>7SSB~600

April and.

1973’

Bbeknreller University Mbthaﬂcne Dita Syntau,

York Ave.
New

snd'ééth Street.

York. 351. 10021.

Gentlemen,
Following the advice of Mr. Anthany Caglioatro, v0
are writing to request partioipatien of the Drug Dependenae
Treatmant Center at the Vitornns Aduinintrution Hospital,
Northport, H.Y. in the Rockefcllor Uhivnrnity Mbthndane Data

System. Ebrthport VA Hospital in a DQan'a Committee lonpitul,
and this program is opertted undar the professional nuparviaion
at the Dopartnnnt of Psychiatry at this university. we
believe that such participation will comply with the existing
regulations regarding reporting of our patients receiving
mathadonc.

fbr

Vb

an

would approciatc your adviae an

to ynrtieipate.

to the steps necessary

Sinaoroly yours.

Mix Fink. M.D.
Profcsnor of Psychiatry

MF/ij

ca.

Mr. Anthony

Gaslioatre

�</text>
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                    <text>7333603~

April 2nd, 1973

Professor: E. Eﬁnkel

and 0. Doloe,
Medisinieohe Hoohsehnle Hennover.
Abteiluns {ﬁr Elia, Neurophysiologie and Exp. Heurologie.
3000 Hennover~xleete1d,
Khrldwiechert~A11ee 9,
Gerunny.

Door Profeeaore Kﬁnkel and Doloe,

I receivod your kind invitation to participate in the
in 197%. The ides 1e tiaoly end I look forward to
perticiyeting.
The outline augment: that near intereete V111 be diseuneedz
the technical problems of date acquisition, reduotion of EEG
and etetietloel pwooeeeing, equiouent (particularly oomgutere).
GEAR

end «polioetions. Bone tonnes. soon :3 eoqnieition, date radiation
and elolyuie. are similar for all projecte. But the epolioetion
or these nethodn differ widely, whether the subjects are men or
eniuele. Shoold the eonferenoe focus on issues both in men and
in animals. I fear that your wish for a “smell" conference vill
be unfulfilled. I autumn that your primary interest is in the

application of these

methods

to studios in

men.

As you know, my eseooietes not I established a ldboretory
for oomguter ennlylit of EEG in St. Louis in 1963, and a second
one in New York in 1967. We next been interested for these men:
your: in upgaying the methods of oooputer ennlynie to different
problem: in peyohophernnoolosy. at now use our methods to
obtain the neuron uiologie grortle of new oompounde (phase I
peyohopharneoology ; and to moeeure the bioevnildbility (neuro~
physiolosio equivalence) of different formulations of payohotropio
drugs. By these methods we hero studied clinically accepted
compounds. preeuned compounds. and such eeoterio topics on
eenndbie, opiates and their antagonists, and induced ueieuree (BOT).
we but. devotea much tine to many technical issues. as the
different analytio yoogrene (power spectre, period eaelyeie.
maplitude integration, vuridbility meeluree), the problems of
the tangle 01:0. etetiatioe (univnriete versus multivariate,
regression vorlun dinerininete function) eta.

�Profs.

H. Kinkel and G. Dulce

~2~

April 2nd. 1973

the provisional aniline. I an pleasad to recommend a
at pines: whare we might honiribute to the grogrnml

From

anubnr

2.1 Camparixon or power spectral dcnuitz, /!‘riod
analysihlund amplitude analyait.
3:2 Proeaaaing EEG data ” statistical applicutions.
’

3.1 (3.5)
‘3.6

EKG

EEG

clansifioaiion or psyehhnetive drugs.

analysia.

h.3 and k.h The

ta

\\

DEC

-

IBM

1800

statistical

PD? 12 (and PD?

15).

package; aonvornion

come at thhne technical subjeats
presented, I would recaanand that you invite my coworhar of many
years. Bunmld M. shapiro,rD.B¢., fur his knowledge of camputer
method: as applied to EEG. (Ha has programmed the IBM 1710,
1800, and 360/ho; also DECi'PDP 12 and 15).

should run wish to have

Alaq’Dr. Shapiro and I havn been instrumantal in estdhlishing
a laborahary for EEG analysis at N. V. Orgauon in 03s. Bollnnd.
Their oomgutor director, James Porsak, had programmnd an IBM
system in Detroit, and is reiponaihle far programming the PD? 15
in 033. He is very knawiodsahla dbcut lacuna in Sectiaha 1, 2
and h at your outline, and I caauend him highly.

I am taking the liberty of onelosing a few raprinxa from
this laboratory which mny‘be rclevant ta your pragrsm. As you
will find, the bolt is that which is at yet unpublished. and I
ma dhle only to send you yrcprints.

I command yen for undertaking such tn arganiaationalgthsk,
I look forward to tho CEAN acutingn with great anticipation.
I thank yau for yhur invitation and trust that I will hnvc an
apportunity to diseual this with you on can or my trips to Europe
and

in tha farthhcning months.
my

best regards.
Sincerely'ynnrn,

Fink, Md).
Professor of Paynhiatry
Max

MF/iJ

Each.

/

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-~

""ra-V—

—-'w'~'-‘

738B:079

~

very“:

‘W‘Wr

:‘
m

April 2, 1973

‘

'v',v~’~'

&lt;~m~nw-mvw_waw-rwu.

\3w1"v‘ww'nr"rr.)w

fry-v

r“

v-.-

v

v

Stephen Keaton, M.D.

Greeellnde Hospital

Valhelle.

Rev York 10595

Dear Dr. Keaton,
Thank you for your kind invitation to participate in
the weekly grand rounds of the Department at Grasslands. I
regret that I will be unable to take part during the next few months,
as I already have an impossible schedule. I have moved my
laboratories from the city to Stony Brook and the transition
will not be complete until the early summer.

Should you wish, I would be pleased to

the fall.

participate in

r~mw~wrwwmw~a~wrw~wm

Sincerely yours,
W

wry-nvanwan-pmmwmwwarer-wwmmww

‘w'nm'

n
w

"1'

urr’vwww‘“

w
n:

“mm-v

r-v

'ww-e:

mum

.mp-

Fink, M.D.
Professor of Psychiatry

Mex

�</text>
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                    <text>735-603:

April 2nd. 1973

HMS? ﬁnch”. xii-Do.
Chairman. Research Gawain”,
Vatarm multratmn Hospital.
Northpcu‘t, 13.2.

Dear Doctor Walter.

to treat apiata Madam:
of the principal therapeutic modalities
availabla to us - ”Wont maintenance am! meatie antagonists
(cyclawcina).
As you know. we have: begun

Mama with two

Methadone Manama requires the daily administration
of methadone. This is both an expansive procedure for the
patiant and for nanny, and man an additional apaeial risk
tint drug given far
days my M: 9016., lost, stolen.
or inadvertently be fatal to non-dependent aubgeata.

$.me

moat modiﬁcation of mathadona maintenance ha: been
the use of a longer acting opiate, lmathadyl. In my
laboratory in Her ram. we have been ramnaibla far am a!
the principal m1; Mel: has dmatratod that levmthadyl
in doses batman 70 and 100 as can be given three times a wok,
roa- it provides aroumwlarama for varied. in excess or 72 hours
(indeed, our parent experiment it tho aduiniatratian of 100 mg
twiaa weakly. and w are most satisfied with the unless).
I m mm»; to propose the transfer of patients who are now on
in our outwtiant mega-am, and who have Men stabilized
mum”
for We months a: long“. from lanthanum to lmthadyl. Under
praaaxm governmental regulations , this 1: faaaibla under IR!) 6590.
Ono

Ihava'boanadviaadhym. E. Gardnarortharoodandm
Ammunition that notiﬁcation that we are carrying out the
study at ﬁlm Vatm mmtmtion 303mm will be accepted
by him. and such natiﬁeatian has been tent as him an Marat: 29th.
Fer your records. I m use melanin; a ccpy of tha protooal
vhieh the original “M1” ware done; and copies or three
rapeﬂmhiah «scribe our mime. The ﬁrst amen in

m

W

JAMA May

appear

8. 1912: and

current

thlatria

for months.

"

ma

ascend 15 in pron, in JAM, and
vault-a and a amry report. for
Than-ariaswhich should swear within 1:124: and:
than

“thin thc nut eight

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,

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sunny maker. um.

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mum
m- Hgtiond Institute of

'

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2114,

1973

of Znulphs—cca‘hylmthtdol (mun)

Mal

no available mm
South. and hue shady bum

Waited with our pursuant.
I mmomwﬂl alsobaploandtakmthnt the“
a.
cox-unto.

ma 1: uranium
«“1311st manhunt“
m
ﬂatten 136.9331: thmtuhm the antics far the annual
causation at IWWJ. 1n opiate mama. It. 1: our
he imlmd in this
duh tint we will
«hm.
VA

T:

»

'
'

3

Q...

imam

«mam

1: tantalum to porn“
I trust that this
our previous aubuiuion far the clinical
max-m of «ammonia! and ”Mac. A: vs are ready to

gamut“ to mad

m

uncut: m, I
amount; notification of thin
mm
convenience.
at
mlili'k
mm m
would

smartly

,1

”H

‘

4%

yours.

mum.x.n.
Profoum- at Paychn‘bry

�</text>
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                    <text>7383.605

Dr. Jannthnn Cole.
Boston state Hospital.
Benton, than. 0212b.

Dear Jon,

or

I an available for the

313%.

or June

In the

A??A

13%.

Couneil on may 30th,

liat of people invited,

Donald Klein havn baen emitted.

Kenry

Brill and

Aloe. unless ynurar Jerry are assuming full
rcaponsibility for the arrangaments, you might wish to
invite whomever is assisting you for tha arrangamanta
aanmittee. should you think it necessary.

Sincerely yours,

Max

yink,

M.D.

Professor of Psychiatry
MP/id

�</text>
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April and,

19T3

Paul de Been, Inc..
Drug Infernation Servieee,

g

E

11 West Forﬁyweeeond 8%.,

5

R“ York, Eff.

i

10636.

Dear Doctor do Been.

I have checked the {ands eveildble to

eouins year. and find that I
year eerviae.

am

me

for the

unable to subscribe to

I have found it

most valuable an&amp; I wish to
onee 15313 to: providing the scientific
community with date which he: been most invalusble for

congratulate you
»~

Me

Sincerely yours,

a

‘

Mb:

Fink.

M.D.

Fvofeeeor of Psychiatry

lav/13

�yawla’e We.

(212) 564-6560

Jew/0.

DRUG INFORMATION SERVICES

11

TO

New York

WEST FORTY-SECOND STREET. NEW YORK. N.Y. 10036

Medical College

Fifth Ave. Hosps
Fifth Ave. at 106th St.
Flower

New

8:

York,

NY

10029

one

3/22/73

mvouca No '

6189

YOUR ORDER NO.

de Haen DRUGS IN USE INDEX CARDS, 1973

[1] Annual Subscription

For Shipment To :

Dr . Max Fink

Dept. of Psychiatry
5

East lO2nd. St.

New

ar

- Psychiatric Edition

York ,

NY

10029

- 8th Fl.

$150.00

�</text>
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                    <text>m.

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#7

June 29. 1973
Murray Weiner, M.D.

Merrill Laboratories
Amity Road

Cincinnati,

Ohio

h5215

Dear Murray,

I am enclosing two reports which I have completed
the
recently, which reflect the thinking and experience withEEG
mthoda
classification of psychoactive drugs using quantitative
in volunteers. The March 23 report was presented at a symposium
on phase I pharmacology; the other report is a short summary and is
included because it presents additional tables, particularly Table 5.

profile for known
antihistaminics in interesting, particularly if there is an active
compund which has different CHB4behavicral effects. You will note
in the report reference to the difference in EEG classilication
The problem

of defining

an

EEG

to dextroamphetamine- compounds with
anorexigenic activity vith contrasting behavioral effects.
I will try to work up a small protocol for your review
and should send it to you shortly.

of fenfluramine

when compared

Thank you

for the question.

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

max

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                    <text>Fly...

,.

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,7

v.7

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-01,“ pp,

..

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7333 2 728311411

Jam

28 , 1973

Kttt, Ph.D.
011mm Renard!) Branch
National Institute of Manta Heath
neutrino. hrylnnd

Martin

Dear

Win,

melon“! are
m today.
I signed with Mr.
mum Ct Winston. and an editor“). which in m in mu in
tho Journal, Biological Psychiatry.

It

was good

carpi“ of the contact
1'

ho

m

My

but "was.

3%

Snowhird

to talk to

Which Katy, MeGaugh and

tﬂ'ed to reach

until

I trust

Manda 3"

you have

Tom

and

his nurse told me

waived the

min

tint

by now.

Sincerely yours .
Pink, NJ).
m
Professor cf Psychiatry

.1:

my

1

a;

-

.

vwvv;

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:1

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                    <text>7:383:72?

Jan. 28,
Mr. Gary Boy-r

Cantor for Studio: of

Hotioul Institute of
5600 Fishers Lon.

Knoxville.

mm

1973

lunatic a Drug
mm Ram: m“

20852

Door Mr. Boyer,

Jam 19 I submitted a. request for 500 Ch
Ila-1.1m. 2.51 no «union for tho withdrawal otudtu in tho
abronio bookish wars in Grace.
8130. than, Dr. Stan Euro. bu
notiﬁed no tho/b the sample: I "quoted worn inadequate for the
on. one hu wounded. that we roam“ 1mm, Equine-dork“!
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bookish, 5.5} me in substitution for tho

Enoloud in x mm 2220 form "gunning 300
1. w inﬂation to tmohip than to Profouor you
Storm:for his use, under my current export 11am. P 10100159).

It
Athono

huhtoh.

in

mum.

“my thanks for your ooopontion.
Sincerely roar- ,

Mu Pink, 24.».

Professor of Psychiatry

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27 June 1973

8. F. Yolles, H.D./Che1rneu, Department of Psychiatry

rink, M.D./Cheirnen, Research

Committee

FROM :

M.

SUBJECT:

Ayplicetion fbr Chart Review. Fermingville by S.J. London, 0.8.W.
reqpeste permission to examine patient records at the
Fermingville aftercare unit of 0.1.8.3.. to determine the eweilebility
of subjects tbr e doctoral thesis at H.Y.U. Be is interested in the
role prior hospitalization has on re-hoepitalisetion, particularly the

Mr. London

impact of "patient role" has on edduntnent to tumily and

to

community.

request: permission to exemine records; to use the date to prepare
e preponel fer review by Professor Whiter Heft end a committee er
5.241.; and to resubmit the final propose]. (1t reuible) for review.

He

Permission for chart review ahould be grented.

mrznpv

w r.-. “my..r...,_,_v

_,

,er ,..a

�</text>
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                    <text>731: llBGr

June 26, 1973
Dr. A! Liakos, M.D.
Department of Psychiatry
University of Athens School or Medicine

Eginition Hospital

Vasilliesia Sophia:

7h,

Athena , Greece

Av.

Dear Dr. Liakos.

It gives me great pleasure to extend an invitation on
behalf of the Asaociation for you to visit our laboratories in July.
We are aware of your contribution to the ongoing study of Chronic
Hashiah veers in Greece under contract 38M h2—70—98 with the ch.
National Institute of Mental Health.
We have received the additional data tron the acute
studies undertaken this spring. and in our analyses, it would be most
helpful to have your collaboration and advice as each of the analyses
7

are completed.

Should it be advisable, we will provide funds for your
stay in the United States; and we will reimburse the Department of
Psychiatry for your travel expenses.

I look forward to greeting you in the U.S. I will be
available in New York during July and most of August, and can be reached
at my office (5164M 2%?) or not home (516—2166 5mm).
My beat regards to Professor Stethnie and to your Vite.
Sincerely yours,
Max

Fink.

M.D.

Executive Director

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                    <text>TBIzllTGr

June 26, 1973
Costaa Stefanie, K.D.
Department of Psychiatry

Bginition Hospital
Th,

Vasillisais

Athens, Greece

Bophiae Av.

Dear Coetaa,
from the acute
administration: of cannabis to the chronic hashish usere, and will
proceed immediately to the analyses of these data, and their correlations
We

with the

EEG

have received the

additional data

materiel previously analyzed.

would he most helpful to the proJect to have Dr. Linton
work with us in Rev York. During my recent visit, I was impressed with
his knowledge of the details of the experiments, and as the analyses
will become increasingly necessary to evaluate each
proceed.

It

it

analysis before proceeding with the next. with this View in mind. I
an hereby extending an invitation on behalf of the Association for
Dr. Liakos to visit with us for a hunter of weeks during July.
Separately, I am enclosing a direct invitation for his use.

Steve Basra called on Friday to tell no that the supplies
of high concentration THC- marijuana were inadequate fer our use; and
offered a supply of hashiah of high THC concentration. There are some
details that have to be clarified, and I have been in daily communication
with him. As soon as the material in available, I will call you.

of

Dr.

I look forvard to your visit later in the year. and that
Liakoa next month. I am confident that we will be able to carry

out the analyses as
My

we

discussed.

'

beet regards.
Sincerely yours,
Max

Fink.

M.D.

Executive Director

�</text>
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                    <text>733:11503'

June 25, 1973
Dr. T. van Lierop

H.V. Orgenon

Ose, Holland

Deer van Lierop,

I have had the opportunity to check one of the coded tepee using
the decoder. we at first hsd much difficulty but were eble, by cerefully
adjusting gains, to echieve the samples enclosed. Tﬁe decoder is very
sensitive end we have to edauet the seine on the tspe recorder very

csrefully.

if they reflect the
tape, it would be helpful if you‘vould advise us how to
reed this code, for our record purposes in indicating the samples which
we may have to reject; end in noting the onset end end of different
code on the

Please check the enclosed samples, and

records.

We have received the couples or GB-9h end ere in the
of
establishing our own doeege schedule {hr enitriptyline
process
hefbre examining the GB-9h.

Thank you

for your help.
Sincerely yours.
Me:

Pink.

M.D.

�</text>
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                    <text>rwvam

;

E

ww-w w—‘r‘

V

»..

x «nu-mn—

A

---7..;..

rmvﬁhymm.
.

.

v

W.Iwmqu.
,

e

.‘ m
.

._ .

.

1",
,

.

._e

av-.

m. n'vw'mr .Vm ‘w'w-m/Hm

www‘u m m-wr
.

731:11hGr
Dr . T .

Penioutopolie

Eginition Hoepitel
Athens, Greece
Deer Tom,

Enclosed is the output of your tape and a summery page. We
beck with each condition as if it were a separate experiment.

played it
There are two outputs, one before 'ertefacting' and one after. The
base period is the first, eyes closed sample. You will note, by checking
the number of samples ertefected, that our staff thought too neny samples
in the eyes open record.were not of cerebral origin, and therefore the
significance of this piece is low.
The eyes open

big differences
must

be left to

record is interesting, there being

in the two samples obtained on dqye
your clinical acumen.

l

and 2.

many

The meaning

I trust this review is helpful.
Athens and I
It was run discussing the project with you inwith
to
soon
visit
you. Good
another
have
opportunity
I
hope that will
withdrawal
the
study.
luck in

Sincerely yours,

Max

Pink.

M.D.

7.. “mm...

v-..-w.-,—... r.—

�</text>
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                    <text>Deer Bonne and Doris,

I went to thank you for your cooperation in obtaining
the blood samples in our recent studies at NYMC. I am enclosing
e token payment with the urge that you buy eonethins for yourself.
Should you be out

I hope the work in New
this wey, please come

my

regards and

my

York continues
and visit.

to be rewarding.

thanks.
Sincerely yours.
Me:

Ma

Senna Durbin &amp; Dorie Giordano
York Medical College

New

Pink,

M.D.

�</text>
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                    <text>WM

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.-

June 22, 1973

ﬁartin Kits, Ph.D.
Clinical Reseerch Branch
Rational Institute of Mental ﬁeslth
5600 Fishers Lane
Rockville, Hsrylend 20852
Dear Martin,

Enclosed are copies of three suumsries of the sections of
the conference on the psychobiology of convulsive therapy. and an
introduction, as submitted to the Archives gg,aenersl ggzggigggz
for the consideration of the editors. These copies are undergoing sole
editing for the volume, end as soon as that is completed. I will
submit final copies for your official use. For the meanwhile, these
represent the principal texts end should be available for your consideration.
The volune is edited. but there are large sections. partic«
ularly in the summaries that require some sore work. I have undertaken
these myself and should here the sort completed by early July» Should
I asst that schedule, the volule will be of! the press in Hovsiher.
The publisher has indicated his desire to withhold final delivery untill
January 2 in order to have s 197k publicstion dots.

Again, I sent

during this effort.

I

am

to thenk you for your support

sending a duplicete

Have a

pleasant and

set to

and consideration

Dr. Schuyler as you requested.

hepuy summer.

Sincerely yours,

Mex

ml
cc: Dr.

D.

schuyler,

HIKE

Fink,

14.9.

,,

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                    <text>June 22nd. 1973
Hr. H. 8. Vellum.

1:10..
northern-m
07110.
Nutley,

NJ.

mam,

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Eula-ed. in e list or the blood eeuplee delivered
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Dr.
that em or the tubes bed erected; tint we
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we

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the» blood mlee. but can ewe you thee should the
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June 2181;, 1973
Dr. 1.. Image,

Department of Neurology,

Central ﬁddle-ox Hoapitsl.

Park Royal.

London, HALIO. Engllnd.

Dear Leo.

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“sonny, sad is new: in sons p.113. This is sufficient
to mks him feel mooﬂorta'ble, but insufficient to
keep his from his bonds” He sskod my advice so to
tho
of a neurologist that ho might see in one he
hsd difficulty. and I have taken the liberty or giving
his
at Central landless: Hospital. Should
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th'st you may xiv-s his.
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                    <text>7383-713

June 21st, 1973

I. Boyd.
Aecoxmting Department,

be; June:

Gnu Imtrmnt

WW.
Bur

W30

Cm,

021690

Mr. Boyd,

I received your letter of Jun: 8th. “around
to no at w femur institmsion. New York Medical 0011930.
Payment will be ad: sufollm:
Invoice l38001w, $68.55. in! 33er received on
5/29/73. and payment will be made by the ﬂew York
Medical Confess by June 30th.
'

Balmce of 1min: for shipping EEG paper. 8181;.35.
Ind not requested payment for thin. as I had not
received a. statement. I have requested for a. check to be
inn-d by the New York
Collage. md this should be
vithin tho nut pay period ending July 31“.
ant to

we

m

313%.

mm.

If eitbar 0: than accounts: are not paid by Jun
plane call or write to an gt my new addrou above.
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rink. 3.13.
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                    <text>mama.

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                    <text>«r.

Wrr‘wi’I—v'

7333—723

June 213t. 1973
George Gerdos. R.D..
Boston State Hospital,
Boston, Mesa. 0212h.
Dear George;

I have read your paper "Low Dose Thiothixens in Chronic
Bohisophrenia" with much interest, and have a few comments
shout the issues that meet interest as.
The

references to the

effects appear to he incomplete.
olerify whet the study
record shows that the heheviorel changes
EEG

and are put in a context ihieh does not

eon-unicetee to

me.

The

that the dropout rate was high. There were few
differences in clinical effects betveen the low and high dose
thiothixsne groups. In yartieularl this reflects a very'high
dropout rate. The significant changes vere a reduction in

were small and

aneooperstivenoss with high dose, and a decrease in depression
with low dose.

It is imwortant to note that concurrent with these linited
differences in behavior, there were smell but defined difference:
in BIG. Kore, too, the level of significance was low. largely
because of the e-all sample. But you could safely report that
high dose thiothixene elicited a lower average frequency.
reflecting an increase in theta and alpha activity, and a
decrease in beta activity (Table 8. 888 report revised 2/12/73).
Should you.ooneider the behavioral data of significance.
I believe you ought to report the EEG data of equal
significance. for the high doses did elicit KEG Ghansss of the
anti hotie class. according to my classification (and that or
Itil
. Low doses did not prodnds say evidence of stimulation
(defined as increased bets. increased variability and decreased
ssplituds), lo the extent that you wish to use these
observations. I would conclude that the hypothesis that low doses
yrodues stimulation is not supported.

than

�George Gerdoe, M.D.

1913

psychoactive drugs. Theee observatione with high dose
showing smell ehengee - inereeeee in that: end
elphe eetivity. which eeeonmenied.behewiore1 improvement in
some yetiente end e reduction in nneooperetiveneee — 1e
eoneietent with our general hypothesis of the eeeooietion of
236 end behavior in nan.

\

the questions that we tried to enewer wee whither
differed in their initial BEE eherenterietiee.
When we eeeeeeed the EEG eherenterietiee or the eubjeete et
the end or placebo with those et the end of low done. we found
no eignirioent differences, which led ue to conclude that the
eleplee were honogeneoue at the outeet. In your analysis or the
hehewiorel date. I mien this ennlywie, It is not clear whether
covariance wee e technique epplied to your ante. which would
enlwer my question; or whether none other teete for homogeneity
prior to treetnent were introduced. I mention this because
yen'preeent the beheviorel ante (your Table 2) in terms of
poet eooree only, and I believe the reader is entitled to know
whether these differences are releted to initial poeition.
the

Amont

two groan:

it

Since you eent me the original. I en.returning
to
an interesting retort end with the enell enendnente
which I suggeet, I would encourege its publication‘
you.

It ie

we've-e regards.
Sincerely yours.

we: Pink, M.D.

Profeeeor or Peyohietry

,nu

i

Zlet.

thiothixene

w-«ww:

”wan-

June

It: neny year: I have been eeeking to nnderetnnd the
relationship between EEG ehencee end behavioral ehenaee with

nu.

w-nwr—m

'-2—

Illid
nee.

�</text>
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                    <text>v

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-,~¢..,. —.n..

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7383-725

June 22nd, 1973
Mr. Richard Duffy.

monarch Mahatma of the State or

P.0.

Box 7126,

“hm.

Kit.

How

York.

12221..

Ref:

ﬁlm—104;: (Mention)

Door no. Duffy,

but month we outﬁtted an extension request to
RM for the ongoing study "Evolution of Eutectic
Antagonists". In nomt’istionn with than we hove agreed
on tho fouoving hudgotu-y diocttionn for the 18mm
period, Juno 25,

1973

to Mambo: 31.

Salutes
Ringo beneﬁt:
Tronl

191M

$82,800

13 .9011
3 a 300

Consultant

hso
10.500
“7.527

Othu-

Omhud

$806

Supplies

$162,287

separately, {on will ho making from W. Ernut
(301- ha—hlST) I copy of tho contmt to ho
Note that ho uh: that the
the
by
“and
contract he returmd to Wuhinaton prior to noon hid”.

T013107

Juno

at

of

mmom.

Mb. (I!

you

516-hhh—2hh7).
Thank you

hon

some

difﬁculty. plan call

no

for your ooopcrotion.

81mm]: yous ,

Mn:

rink.

ILD.

Profuoor of Psychiatry

wit.)
co. to

m.

-

H.

Christan

v,

�</text>
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Juno 19th. 197 3

Chad

th

Bunk,
22 Green Aroma,
(but Hock, 3.2.

Gentleman,

Pluto «noel

out on bum:
amount of $2.500.

made

cheek 01211

and April
14.13;

of Coat“ Btofmiu,

10, 1973.

in the

sincerely you".
Fink. 15.2).
m
Executive Director
149/13

�</text>
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                    <text>TSBB~713

June 19th, 1973

CORIQ

-

DOW g; thietg
'

.

June 15. 1973
The Depertnentel 003188

net in the litter-7 st

11. OD emu; Dre. 8. Mex-lie, E. Rubinstein and H. Fink

(mm).

project "Effects of Televieion on Children's
Prosociel Behavior" we discussed. The Committee wee
eeeured thet the rink to the subjects we minim. In
e. dimeion of the permit. the
Cmittee suede the
1.

The

following suggestions:

(e) the study by limited t9 children with
went: rether then then with a. guardian;
(b) the sentence

."1'

he" been

informed about

the other deteils of the stw to w
estiefeetion” was «ended to "I heve been
informed stout the deteile of the etw as
provided in the ettsohed description"
(Pumphe 2 end 3 o: the deeeription of
the pro ect should be suede eveileble tea the
-.

perente ;

(c)

it see suggested thet the lest sentence not
proviae the 91m“ "to defrey incidents].
costs" but that it specify the complete tee
to be peid for pertieipetion.

The Committee vee eesured by Dr. Rubinstein that the
videotepe of the subjects would not be shown publiely, end

thet this usurenee

m edded to the torn «knitted end

signed by Dr. Rubinstein.
With

these

unmat- the proposal wee

sprroved.

�The domino: discuss“ the potential source of
2.
other project: and indium that 11: would bu willing to
review all pmjoata curring tho «Mum's mprmtw,

should

the Genius: be requested.
The Comittu adjourned at 12.10 pan.

Ht!

nut.

Chaim

MW 5.3

“the

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                    <text>7388-6h6

April 27. 1973
Mr. John R.

Coxsolino.

Harootio Investigator,

Suffolk County Health Dept.,
Eonpitol Affairs Division,
Route #113,

Rivorloizh Avo.,
Bimb.“ , Ho 1 a
Door Kr. Coozolino,

I rogrot that I nova had to cull you. The
enclosed letter from tho BHDD invottigntor indicates
that BHDD is unwilling to provide the necessary
registration until the State rogiutrotion hos been
completed.

Thank you

for your cooperation.
anooroly yours,

Pink, M.D.
Professor of Payohiztry
Mu:
Mir/1.1

Eno.

�</text>
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              <elementText elementTextId="56682">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>J-«u‘tz‘wn— 4-3.;

.-

-3-: anus—w:

w" «7- :;v «ems-:1&gt;rmn~r1xv¢wxrs

.

£,\‘.'Nl‘,:

Wrsc-I

‘

,

A

_

'

'

,

.1:-

“ma-z xymmxawvmﬁwu.

'

uplu . -.~y

-

~:»)--v(-."§‘-

M
7383-712

June 19th. 1973
Dr; Richard Abrlas,
132 Columbia Heights;

Brooklyn, N.Y‘
Dear max,

I‘do not rceull whatnot

the rcport

v. ova-rod rdprints or

from Cbmprchcnoivn Pbyahtatry.
noun, 1 would ayprcaiate ten copica.:x
.

It yuu

-

-"

htvc

I

Enelasod in a.ruprintvrc§u¢st aeht by one of my
friends. I tn also enclosing A roqngat fran.Joc Zhbin

fur tha other paper

and

it

-I

glue Isak reprints of this one

you haw. any I.wou1d apprcciato 10 copies.

.

I

Mhny

thanks.
my

best regards,
Sincerely yours.‘

”I! Fink. Hm.
Professor of Paychintry
MF/iJ

h¢.

o

n

.wgun

:

‘

V

....1:.~;

�</text>
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                  <elementText elementTextId="103777">
                    <text>nan-111
June 19th. 1973
Dr.

0mm

sum“.

Profane: of, Pawn-am.
Univmity or Athenn School a! modicum.
mutton 301911;]...
Av. .
7h,v»1111u13

Athena.- (Ix-«cc.

Wu

6mm;

new

an m
mum.

Inaﬂtuta
1mm by the Human
of 1mm Bum: that they :10
1m. 2.5:! mew-‘9
I m "gunning 11b to be shipped to.” today
and at. the.
that
"quantum a. BBB!) export permit.
1113 my emanation ﬁlm; I would in" most or this
I-

m

mama w1th1n

a

1m

mks sad uhould than be able to
Iphntoshipthcu’aerinlundoryour

two

“lantern;
import 11mm 12km. u I luv: requested 500 grun-

mat many.

emnabit (mum) from the $1.8.
tha Inﬂow Insututo of mm Knuth.

My best regards.
8111mm}: you".

in: ﬂak.

14.1).

Protcuor of Psychiatry
20/13
nun.

v.3. I awn manned. eh“): (1271. awed April 10. 1973.
Eneloué 1: n rmlncmnt for this chock. It you find
the M13111“, plan ants-u}.

�7383-700

Juno 15th, 1973

Costa: Stefanie, $1.1)...
Prof-nor of Psychiatry.
University of Athena school of Medicine.
Egiuition Eoopim.
'

'

’

Th, Vuillissie sophiee Ave...
Athens; Greece.

Denr Cootes ,

I very mach enjoyed our visit and was very much
impressed by the extent and quelity of the work that you

end your

usocieten have

done...

Enclosed is a review of the budgetary allowances,
mount mid to date. end the muse. to the end of
the your. It in peninihle to Water fun!- from one
category to mother except that equipment my not he
bought and that travel expenditwre: my not wooed the
snowmen given.

m

I

have spoken to Dr. Euro about the high concentration
At first. he felt that huhioh should he used.
but after noon discussion we earned that a. high dose
would be eoooptehle. I called Mr. Boyer, who
is responsible for the
suppliel. one! he is checking

mum.
mum

m

the availability of e high oooteutntion. Meanwhile,he
hes not you ho edditionel bottles or 3. 8% marijuana
using; your import certificate 121310 ma on export licenee
from 31m. .1 m to can hin'oorly'nez'b wok end'if higher

oonoentretion euppliu can he obtained he will get them.
if thou
is unnotisi'hotory. perhaps you could check with Dr. Miro:
wont 0, supply or high comentrotion heohioh.

In the nonwhile you should cheek tho 1.85; and

Baywatch, I on sending you the outputs vhioh I
failed to bring with M. on well us an melyoie of e mic
depressive patient which Ton “keel u to do for him.

�60.“! MGM'.
tom .g.
u
v11}.
sheets.

N‘D‘o

we

'

3733. 15311, 1973

“*2“

mm obtained the nautical data.

as
all
m an.
new iron, some other mans. that. I should do m
I smz attend to than in the coming week. For. the
VG

do:

tn. may.“ 1n due-mud. as

ruin! the yam-mks.“

W119. what with“.

’

Sincerely yours,

Max Fink: .1 Mob.

Profs-gar o: Psychtwry

W13

he

0

.-

�Wm"

..

,

,

,

,

.‘7'm'mvmm-I

6/12/73
I

at

E

* aubco

tr

.

000: ~ haagggugg;

.

a. stipgnaa
1).

Ow

,.

$88.hoo

Volunteer. fees

12.300

a. Eonp1t¢;1x&amp;$;on

gggg

'

1,850

a. TQlcphane..§ostugc.

t2 hzlzzg

gagggce

to 12[§;[13

$56,151

$31.6h9

10.3%

1 ,9h6

o

1.850

600

no

560

7,000

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2.500

3.330

2,112

3.310

1.690

1,620

328

3.593

1.680

15.300

$77,135

$603136

'

a.
§

Lab. gnnlysis:

r. Mitcrinl
3.

EEG

&amp;

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suppaiés

rooording

h. Travel

,

.

3.921

.

1. Consultation. services 16.980

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yaw

my.

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$0M

$137,391

»

,

mm

�7M73
May

17th,

1973

Cantu Stet-min. BM). .
Professor of Psychiatry.
University of Athens School of medicine.
Esinition Hospital,
73;, Vu‘illiui: Sophia

mm. arms.
Dear

in.

coat»,
I bare ma: arrangement! to

win in Nahum

mmreservation
to stay at the
I

from
have made

Britta“.

a.

on Tuesday afternoon. June 5th, and

should

Grand
meet
with
like to
you either
time during the max: two days.

that evening. or my
I should like to be able to review the data. which
Iwinbebrinsingvithmvithmmdym
”mitten; the subcontmt era-anion; and to work

with

m in planning the 1711;116:3311 ﬂaw.
I

to Maven Sun to 1:911 him
we written
be. in
I
became he has

the time

ﬂat will

Rhona,

bun particularly interested in tho next phase of
the grow. Should. ho be (bin to Join In. it
mm b. no.1: nimble, and I have extended tn
invitation to him.
I look forward to suing you.
ﬂy

best regards,
Sincerely yours,
Mu Fink. 11.1).
Professor of

10/13

thhm

�7313-651

April 2'! , 1973‘

Cetus Stefania, 1a.». .
Minna University Mica]. School,
Department of Paychictry.
Eginition Homitcl,
Th,

Vuiliuic

Athens, Greece.

Scrphics Av. .

Dar Cantu.
Whenever

I sit cad think of writing ta you the pomlcr
- "Is wane listening, in anyone there?" comes

song tron ’1776'
to mind.

Bumtcly, I

mm

have sent. by cis- c

muse

containing c

statistical prom-m cm! a tape which contains thou
on cmn tracks at the appropriate 3P1.

mun-.1 or

ham: been naked. to com to Wuhington on My 2nd to
mgotiatc the «tension of the contract. I an naming that
with your
the tuna raw-tea in our letter at MI: 15th
We

gnu-07:1, and
which

we

will

do our

at
but to 0min full upprcvcli

I an enclosing a cow c: c

all:

macaw

you about the status or our

given m by Rhea

emulation.

for m to ruin the progress of the but
nice the men-cry plums far the continuation
of the data of this
phuc and the
interesting cm. Should you with to cm to the United States
within the cm nix nooks, I mid be and to work with you hora.
mama this not be feasible, I would then suggest that you let
an knew what is 011311311 for you. sad I will try to com to Ail-3cm.

cmmlc

It

in

bar

but

few math: and to
of that withdrawal

W

regards.
aim-arch

mu ,

ﬂak.
m
weaves." Director
111.1).

90/11

M.

�~3__(,..1.

.n.

,3...

,W‘WF.

731-5568
Marah

5th.

1973

Dr. Costa: H. Stefania,
Athena Uhivcrsity medical School,

Dcparﬂnnat of Psychiatry.

Eginition ﬁalpital,
7h, Vasilissin Banking Avo..
Athcnl. Greene.
Dear Goat‘s.

cro progrouuing very well with tho EEG datg.
Banana: of sum: (haunt raeordn. v3 hswe don: the
regression aanlysea on 16 tubaecta, and this soon: to
be adoqunte to givv u: scan data far tho differences
bctuaan the variaun aonditiona. The bohaviornl data
which Rhos brought back with her has been coded and
aorrol&amp;tians between tha EEG and the bahnwiornl
intbrmation or. nuv 1n progrcta ~ sons having bcan
aompletud during the lust few days.
Rb

callcd Wishiagton on a number of
occasions during the ptnt wusk. but v. an not have
any more infbrmnkion. It I do not have a clear renponte
by uhruh 10th. I will «all, and it that. is no anlvor
by the 15th, I will @311 you. A copy at Khan's report
ta In which V: have tile&amp; with Dr. ssara is enclosed.
Khan has

my aoeountant hAs been over the receipt: uhiah
Rhea.brought with nor. This dacumentation in adequate.
Enclosed is our shock for tbs fbur inwaieeu of January 6th.

In order to obtain :n export license, 1% 1:
naecisary to file a whole act of docunants - which I did
on March

lat.

Rho: came bank must onthnnltstic rcgnrding the
canton: of tho work,'us 1311 as tho cooyerntion which
aha receivud. Mhny thanks.
my

best rognrdl.
Sincerely yours,

Fink, M.D.
Exacutive Directer

Max

Kilt:
ﬁnes.

�731-5131

February 13%, 1973

Castes Stefania, M;D.,
Prefeeeer of Psychiatry,
University of Athene School or medicine,
...

”mm.

,
.v

a.

Eginltien Hospital,
Th,

veeillieele Sophie: Av.,

Athens, Greece.

.v.,,.,.

T
.
v

.
..

:

Deer Castes,

4!!1;'4':~I

«rip

w,

van."

WW

Enclosed are cheeks-1n the emeunt at $13,365 to cover the
aeleriee for April-June. 1972 end catchermbeeember, 1972. I
will need the eencelled check: the these eeleriee as well as
the ones issued for Jhly~8epteeber.
Copies of the expense vouehere for $l,lho are also

necessary.

I em returning the other veueher requests and eat that
these be rendone. I have made suggestions on each, which.v111
ellaw me to meet the reqplrenente of the auditors.

first

Xon should knew thet in our
year. we were ellewed
some overhead for the expenses in Greece, end should there have
been dieelleweneee, we could
been on these funds. Since
June as. 1972 we next been lenied en overhead allowance. we

fell

eoneldered cancelling the eentrect hue cur interest in the
study impelled us to eecept e bed contreet. (Indeed, if I were
not personally involved, the Directors veuld have rejected
washingeen'e offer). To protect my Boerd, we must have adequate

reeerde.

You will reeell thee you rejected direet payment of your
personnel, using netlonel pride and year need to relete to the
start as levers. I eeeepmed your with. as I accepted the HIMB
deeend for e nn-overheed eontreet, to aeeeeplieh the mission.
sue. the rink to the Aeeoeietion in too greet end unless we
obteln adequate statements. eheeke, ete.. we cennet continue this

eontreet.
with

I

An

Rhee

will tell you, I em too fetigued with contesting
e threat of lee: of money fer ee little gain that

EIMH, end

unenthneiestic about continuing the eontreet utter June 25.
I have applied to RIEE for en exteneien, no es not to
Jeopardiee your chances. end will endeavor to support these
em

1973.

�Goat” Stefania,

$.13.

«Eu

Inﬁrmary

studies. but your coaperstion is critical

mutants

1:5

the financial

Sincerely yours,

Max

new/1.3

Emu .

\r
w
-«v-

,.
..

v.;—~:e~,m—v-;m«,um‘

my:

«'1va

r

w-wrm-qw-m

.,
,.

1973

mutation of the interacts of my associates.
briefed and will try ta amplify the“

and in thc

Rhea has been

issues.

..

lot,

Fink,

M.D.

�--wwrcmx7.-L

&lt;

731-51111

deruary lat.

1973

Castle Stethnis, M.D..
Protasnor of Psychiatry,
Uhdersity of Athans school or Medicine.

Rainition Hospital,

7h, Visilliauis Sephiaa Av.,
Athens, Greece.
Duar Cactus.

Rhea, Vbita, and

I hsvc read your

I

35

summary

report. and found

or intarost and significanca. Vb raviawud «gen 0: the
seetians and an: comments and auggeationa have been noted.by Rhea
who will review these with you in Athans. My own antes, which
she will amplity, are attached.
much

hnwn ankud

with ynu.

bar

rcviav the relieving technical issues

(1) The report has been aunt to Dr. Rdbcrt Petersen.iﬁ§wgl

I balieve the data is sufficient far thalr review

r.

and dacision no ta
any eontinnttion qr «xtenaion. While x hawk rumindad than of cur
agreement, I am not sanguine thnt they will be dble er willing to
umvm.w1th any slacrity; and vauld suggegt that. shauld yau wish to
eontinua this interaating tyye of work, that alternate sources of
anymort be sought. I huva diaeusseé than: with Rho: and she is
prepared to assist you.

(2) Bath the raport in August and this report taka little
cagnisanoe of the contributian at my unneeiates tn the studios.
Recognition of eontribntions is always a delicate issue and when
w! discussed this in Copanhagan, I trusted to yaur Judgement to
protect tha interest: or the staffs invulvmd. This report seamed
dafiaiant in this regard and I hawu made sumo amenanants, whiah I
trust £411 much your approval.
(3)

we have redunea

all the

EEG

cage: by perioa analysis, and

huvu 16 sﬁbaocts camplete with 5 cxparimontn each. The initial
proeessing has been done using our linaar rugreaaion analysis model.
The drug eonditions are distinguidhdhle tram placdbo, in patterns
similar to that reparted'by Vblawka and Dorubush in their earlier
studias in v.3. voluntaers a&amp; lower doses. The analysis was done.
including ﬁhn post-smoking period and the postnteating EEG in a
single analysis. A: the varidhility is high postuteating. additiannl

analyses are in prograaa using a quadratia regression modal, for
the firnt pastanmoking period. In aﬂdition, we are aarrying out
sums npacial analysas to amplify the changes in the alpha bands.

�Coatee Stefenis, M.D.

February let, 1973

~2—

These date should be complete in two weeks. we would like
to undertake correlative studies, of the EEG, heert rate, eelr~
reports, and some task performance data. volevke has used e
"forced regression" analysis model for our heroin and cannabis
date with success, and'we propose some similar studies here.
Rhee has e list of subjects and date which we will need to carry
out these analyses.
'

(h) Ae‘I hawe written to RINK and discussed with you. the
findings of these studies are of considerable interest and we must
give thought to both the mode one time of presentation. we have
dieoueeed the question end Rhee will discuss the enclosed
memorandum of our suggestions, and hopefully we can outline e

set of steps which one

needs.

eeooumodete our mutual

contributions and

Rhee is bringing the battery you requestea, es well as some
cannabis materiel. On her return, we would like to send samples
of heehieh, and residual marijuana end THC»A~9 to NIMH for assay,
end I would appreciate your making these small samples available.

(5) The initial threat for this study was the observation
elowing reported by Professor Mites. The EEG records of
the heehieh smokers were examined by h neurologists, and the controls
by 2.‘ But, a critical reviewer could argue that the obaervers
knew which records came from beehieh smokers and which from controls.
Perhaps, it would be worth the effort and coat to code the 60~7o
reoorde end ship these to an independent, experienced

of

EEG

electroencephalographer of known reputetion.for a detailed report?
Rhee has some suggestions for candidates in the v.3. and Europe.
.

(6) There are problems

in our book~keeping thick is of the

following nature. The auditor: will require "belk— ups" thet the
salaries were paid as specified; and that the expenses for
supplies were paid. I believe you are depositing our check and
issuing your checks for the expenses. I need the processed check
or its coyy for salaries; one the bills with checks for other
expenses. It cash, your initials or one or your staff certifying
e eeeh payment should be eatiefeotory.
Again, my congratulations on e fine report and my best regards
to Adele and your eeeooietee. I look forward to seeing you soon.

Sincerely yours,

.yr/ia

Mix

Fink,

M.D.

�gaggestions for Presenﬁatian
A; Se

ate

1. (a)

A

(b)

A

Re

social, madleal, neurological aummnry of the two
population sampler. with emphasis on the soainl
characteristics, snaking history, work and family
charactariatica. Ineluaing a hiatary of the sample.
Stefania. Boulousouris. Gefou, Liakos
description of thc undieal aspects ~ phyaiaal
examination, mantal status, EEG (clinical), Echa»
EEG, pulmonary.

ﬁvefanis, Linnea.

Tam,

etc.

‘2. Psychalogical Characteristics of the two populations 9

I.Q..

W118

subtext:

and pwofile, mamory

Darnbush. Kbkkavi

tasks.

3. Acute Experiments

(a) Ensign, goals, dosages used, with type: of psychiatria
response, esse deseriptiona.
Btefunin. Boulougouris, Dorﬁbuah

(b)

and heart rate; relatinna to each other
gal! ratings; tolerance?

EEG

Vblavkn. Tam, Fink

(c) Paychologieal

&amp;

and

to

stetania

teat datagw , pupils. etc.

Kbkkevi, Listen. Dordbush

h. Tolaranne Duvelopmant: latﬁer to
Fink, stafanis
5.

B.

A

1.

EEG

JAMA.

eftaots (brain effects) of chronic hashish
to editor.
Stefania. Tom, F1nk,Vb1awka

~

letter

siggéc Vblgag

int

t

History or atuﬁy; Alma.
ﬂank

2. Ghamintry or hashish; history of hashiah uaa in Greece;
hiatcry of sample.
Mirna

�n

m&lt;

‘5».

suggestions far Preaontation (Continuga) * 2

of users
Idcntificaﬁion

3. (a) Sample
390131

Mhdieal

Heurophysiolagical
Psychologieal

Seton

Goran

Gefau
Liakos

Tom, Vblnwku

Kbkkevi, Dorﬁbush

(b) Sample fbr control

Stefania

(a)

Stefania

Camparisona

h. Acute Experiments

(a) Goala, design

Stefania and Fink

(b) History; methods; aescription
of subJects; aropwouts

Stefania

smoking times.

«A

behawior.

My

rim

intarticw

n.

WWW

(c) Prychologicsl

tasks.

"0....va

an,

(d)

EEG,

and perfarmnnce

heart rate.

Dorﬁbuﬂh and Kbkkavi
Tan and Vblnvka

uKWI—rl‘w?

(9) Chamistry of substaneas.

Miraa

(r) Significance fbr drugs,

Fink, Stefania

mm

rr-Irw

Jar-WW";

WW.

”my

a...“

-my

mmY’w-‘Kx—w—a

«menwrrlr

u

«

warn-pr:

-——.-

v

r

.n'"

tolerance, interactions at
comgonents.

5.‘W1thdrtral Experimmnta.

atefunis

�15

antrgl«85g§1e

”

,

Egblﬂ’

..~

.
r;

'

why ware patients admitted to hospitals?
Any relation in tins to smoking hashiah?

c

A.

-.—

.M‘

there differencal 1n tgﬁes at Jabs?
factors eould contribute to tha difference
in two groups in rnta umployed?

Employed: ware

.,.V

.A

What

all-,m.

v

,...

Should E30 racords be rdviewod by independant
EEG'ar using coded records?

.

P
A

.

e.

n

'g‘

~

differences are troublesome.
they reflect effects of drug use, they vuuld

The 8TH and “£18

If

.~.,n..-A-n-

rcflect brain ahangea

&lt;n.‘-_.

differcnees? If nut.

~

do vn have

how much weight

given to these solitary findings?

H

-

”gym”

2

3%..

a!

nge g;:

8-

other

"

is to be

tannea
The aneeaotal stamanents dbout #7

are important

roflaatioas of tolerance. ﬂow long does it take
the men ta develop tolarance? This man ware he
to be tested again. could give an idea (antuming
ha is using hashiah).
not an analysis or aovnrianca ha a better
model, since aubaeets differ widely as to starting
levola? (toe Diagram II - page 33). This in clear
in diagrams IV and V, where dose effects and initial

Would

level

seam

to interact.

aritienl graph refleota one of the principal
effect: of eannabis. If the grayh 13 correct 78 mg
TKO a; marijuana has a great an effect as 160 mg
This
THC

as hashiah.

What

are the significant

i !D
Aua&gt;c&gt;n
The heart rnta effcet ulna
relationships?

(or)

A

n

B

C

parsistn for much longer
than anticipatad. Are A, B, and/or 0 still &gt; D
at 10, 15, 20 minumen postwbreak (3 75 minutes poat~
smoking).

Ara

these to be intoryrotad ta the result of

not drug related?

RV

and

�Quastiona (Continnad)

-

2

TEE content. To vhnt extant
what thqy wnre getting?
(or
guess)
did
Are that. data sufficiently consistent or reliable
to allow name canaecturea that aalfwrating is related
to dosa cf THCwA—Q while heart rate is not?

5g;_8elf ratings fallow our
aubjanma knaw

51;.Hhat is "fault index"?

hE.

to interpret these as drug effect at 30‘ and
practice affact (or loss of drug effect) at 70‘? acre.
too. response is related to EH6 content.
Are we

:9. Data far grineludaﬁ. Is
wall?

it

available for other tests as

6. Behavioral responses scam most marked in a 2:?
subjects: ho, an. In 2h, 35. 38, and El thnre in a
raaponae to placebo as «:11 I: there any alum in personality
or amount of smoking done in an and ho to relate to the
sevare raaponse?
.

�‘

(mentions (Continued)

A.

-

3

5118'.

B.

@@

Cl
1).
I

E.

�Contigued Sggngrt

Manner,

1. Ford,

2. Greek funds
3. IBM

*'

m,

Howard Enamels. Dreyfus.

- unassis.

"80¢

Suggest Stefania and Mira: deeide if study is worthwhile and,
plan to approaah founaations with these pilot data.
7,”,

&lt;._

”yr”.

,
~09».er

If

he niches v.8. intervention, nocda an agreement between
Dornbush (who will have to go to agencies) and himself;
or ?rcedmnnd and Dornbush.
‘

Jam

Suggast project leave
3 your support.

NINE

and seek more "indepandent" and

��W

.F—

‘7"

‘

’

RoberW’PéterseﬁTPh—U.
Chief, Center for Studies of Narcotic and Drug Abuse
Nationalinstitute—of—ﬂenﬁﬂetlth-~—~w~—~ v
5600 Fishers Lande

“a

_

W

,VﬁchgvilleArﬂand
Dear Bob:

M

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VA‘

7—“

elaboration of the characteristics of the control population
and detailed comparison with hashish smokerswill be the subject
{m
of the January 15 progress report.

_Ar_1

[7441 WWW
36 J-Zé
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——

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cgntrols. A deiaihiféﬁﬂﬁmﬂimmmiﬂshnserimsincludei_ WWWin the report sent to you in August. Thus this paper represents the addition
of/ controls which were absent at that~—‘time.
v"_—i——”_
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i~~ «Ms
October 15th
the
This report ‘1‘!“ includes a summary comparison of hashish users and

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‘

‘vw

:‘vI'W-‘r

V

7383-716

Jun. 19th,
To:

Stanley 1. 20110:,

PROM:

Max

SUBJECT:

Equipngnﬁ '-~

I
(1)

-

(2)

-

wuuld

Fink,

24.1).

1973

M.Ds

'

like to’recammsnd two items:

1‘H?-h§lAdwuaeed‘Seicntifta Pocket Calculator 0 $395.
1 Hewlett Puahnrd

series 9800,

:Fragr-Innblg Calculgtor
Kbyboard

11222A
112%3A

autumn“

'

User Definnhlo

mum.»

h,9?5

_

aytion:

1122114

Model 20

'

ROM

$1385

(wry)

885
222

1.195
$6.170

To upmgrlde

this instrumant to

tho tailoring:

Peripherals:
9860A
9366A
9862A
9865A

u ninicompuxor would roquirc

Ihrk snug om: Reader

Tharnnl Printar

new»

Tape Csuscttc

$850

2.975
2,675

1.

0

8.290
$1h,h20

Th1: in equivalent to d DEC .3311 proeeusor. hovuvcr, 3nd
should you with all the appendix-a. 3 DEC may be better.
M7/13

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                    <text>7383~?10

June 19th. 1973
Mr. Gary Boynr.

Center ibr Studies of Narcotic. and Drug Abuse,
Nutiaaal Intuitute of Mental Health,
5690

Fight?! Lane.

Knoxville, Maryland 20852.
Dear Mr. Boyer,
A: V! have discussed, w. are studying the effects
of unrijunnu inhalation in ahronia hashish “sure in
Athcna, Greece. undnr the ntudy pwogrwu 38M h2~70~98.
Our luﬁclt pw¢3e¢t, thrlnl;$eﬁ in conjunction with Dr.
Btnvt saarn of HIMH,1¢ : study ef’th¢ errant. or scuxe
withdrawal in those nan. Boasuua we ﬁbula like to limit
the tint If snaking, and haeanao than: man have a high
auarec of toleranoc such thni thay achiave noun satisfaction
only when they htvo snakod 120~180 as equivalent TEC-A-9
hashiah,¢r unrisuaaa. we are reqnnnting n supply of mnriJunna

vith a high aoneontration of wao~A—9. Ehia will permit us
to have ﬁns subjects snake within a 20 minute smoking

period and coneeatrntn our behavioral and phyliolosieul
observation: under’gontrullcd eanditioas.

I an enelaning a BNDD order for: 2220 far 500 grnas
nuriaunnt (2.5} wﬁcmbp9‘oqnivnlont). It in my intention
to trannship those ta tn: university of Athena under an
‘import permit that Dr. Stefania has recoivud. and with an
export license which I an requesting eoncurrent with this

letter undar
Iehedule I).

my BxDD

rogiatration

PF0100759

(exporter,

ihank you very much for your gocperation.

Bingercly yours.

Fink’ ”.90
m
Profousor of Psychiatry
MF/iJ
En” ‘

�</text>
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                  <elementText elementTextId="103779">
                    <text>TBSB~705

June 18th, 1973
Mr. Frank

J. Liaka,

Mbnagtr,
Corporate Data

&amp;

Informntion Services
Meeting).

(BIA Program Committee 8%!)

0.

saarle

D.

&amp;

P306 BOX 513.0,

00..

Chicago.

Illinoin

N” IQ“.

”5113,

"EEG

At

the

60680.

I

DEA moeting.
presented a
OHS Bioawuilnbility of Payohoootivo

1972

Indians of

mm

.

report

thereafter I gent a copy for publication
reports. and have not heard from the editor.
I am writing to enquire vhecher you have any
information regarding the publication of that report,
and should you not. porhapa you could direot no to the
aypropriate paraon to oaks an enquiry.
Drugs".

in the

Soon

BIA

Buoy

thanks.
Sinceroly yours.

Fink, M.D.
Professor of Psychiatry
Mix

MF/id

�</text>
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            <elementTextContainer>
              <elementText elementTextId="56732">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>FNW'1'vxI3'V‘fav

u

.

m

r."

r

A

. W...

W

&lt;\

73SB~TO9

June 18th, 1973

Dania

rw—Wrwwnrrnwyu—ymxv

W0”, PhoDu,

A.

Eastern Pennsylvania Psyuhiatrie
'Henry Ave. and Abbottsfbrd Road.

Institute,

Philadelphia. Pennsylvnnia 19129.

-

.r

"u...

a“

1|

_

Don;

Sth

months ago I_wts yrupuring a review of

the
canditioning'hypothesis'for the etiology of opiatev
dependence and decided, at that t1m§,to report our
'attempts at using this mathbd for the treatment of
Ladicts.. In reviewing the duct. VB fauna that we had
failed to carry out an adequate test a: the conditioning
'hypOthesia and were left largely with naturalistic
data suggesting that tolerance to the_antagonist1c
effects of cyclaaocine‘does not occur; that the,drug
is safe and easy to adadnister; and that the means far
int adequate teat do indeed exist, but thgt it would
require some special effort.
'

«

,
v—mw

w

wyv

(nun—

“a."

'

y-uwv:

Had I attendea

bac&amp;unc

I

tn:

van detained

meeting

in Montreal

in Europe), I

(I did not

would have revicvwd

our exyeriénce and ntated that a test of the hypothesis
yet to be'dnne. There is, therefore. no manuscript
thst I can send you. save raports of our experiences
with cyclazocine - a capy of one of thus: is enclcsod.

was

An

my

a...

boat regards.
Sincerely yours,

w".l..-.__...—ng-

n...»

.n.

7—hwllﬁg‘

w-

Mn:

.mv

H...

:-

vw‘-«n.-,F.W..r-

Fink,

M.D.

PrOIEQnor of Psychiatry

u

ur/id
Enc.

-

\E\\

�</text>
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                    <text>Wu“

,

www-

.

‘W'r‘

ﬁavvlga-Pw‘v-‘P‘,

7333-707

June 18th, 1973

Ernst M11. 261.1}. g ‘1
Lafayette Clinic.
951 Lafayette East,
Deblo1t. Nichisan h8207.
Dear

Ernst,

It was

/“

to see you in Boston,

and I very much
next day, an trrival at my
laboratory, I was mat by the Ghuirunn or our departnnnt
who indieuted an inherent in tons new oquiynnnt for
tolcuctry of EEG signala. Rocsll1ng tn» many difr1cu1tion
we had in Missouri a few years ago, and recognin1ng that
your syntan 1: operat1onal, I would be grateful it you
could d1ctate a short not¢ ind1eat1ng the type of
equipment thst you now use, tho minufaeturer. and nodal
nuibert. Should yau have intornst1on of sons improvennntu
good

enjoyed our lunch.

The

that you would 11k: to reeommnnd. I would-be grateful.
roaommend your cyltcm, s1nao
I know that it is opcrutioatl. I would need. I believe,

nlthough my inclination 1- to

spacif1cntions for tha hegdset. d1polo receiver and

unplifior.

Should you need some upo¢1al help with thb ntutiltics
of your tegretol data. plans: don‘t hesitate to cull on

m.

Mhny

thanks.

my

best rognrdl.
Sincerely yours.

Fink. H.D.
Prafensor of Puyuhiatry
Mg:

HfliJ

�</text>
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                    <text>;

V

7383408
June 18th, 1973

Wham Traynor.

Ms .

55 West 70 Street.
ﬂew Ycrk. NJ. 10023.

.

DwBarbera,
35m:

very much regret. rewiring your letter or my
I
indicating ems. there might be
difﬁculties

the

at lthe Cornell installation. I heme ﬁnally moved gay whole
awaﬂon to Stony Brook. and am new in the proeeu of
reorganizing 2w laboratory. As my" cell to you a few month-

I will

need some help with the 1800. but;
best ‘tae
this . There are some
update programs which require professional help. but
as I understand from Donald, therein no urgency with
these. I am also interested in expending our programs.
ego suggestea,

am

not sure yet

how

We

em

Some time timing the
I should have a elm
of what I need, end would like to be able to :39th
you than. From yum- lettzer. I presume you would not be
Willing to come to m): at. Stony Brook to test out
programs, although I imagine you would prefer to do most
of year work in New lurk. Thank you for letting no knew.

11mg.

Ky

best raga-do.
Sineerely yours,

Me:

Pink,

24,1).

Profuaor of

m:

thutry

�</text>
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                    <text>mm arm "ammwmmm—w

"awn—w.“'wm«mh—nmnwrvmmuwmwm

7mm
June 15th,

1973

Dr. Vera. Rubin,

1080
New

Fifth

Ave. ,,

York. ILL

Door Doctor Rubin.
_

to divans: your study of
W roe-.11 that we are

few years ago we not
use in Jamaica. :You

A

sta
involved 1m parallel gum or the physiological
effects of

1133211311

in

Greece».

are «ﬁghting Our mum, om! I would be
grateful if we could be plum! on your mailing list for
any reports men are. or will soon be presented no that
we may (30331er the» in tho 'mluotton of our data.
‘39

Porouthotioally,

tint we have "on that
lament physiologic

now

chronic hashiah use (loos have

effects. we regret mu more our inability to carry
out a parallel study in Jamal“.

H best

personal

"Mu.
Bimrely your: ,
HI: Fink. Md).

*

‘

ml 13

Profeuor of Psychiatry

—

�</text>
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                    <text>mam
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vv—x

‘

war-y,

7383696

June 15th, 1973

J. Greduoll.
Contract: Mhneaement Section,
Greats and Contracts Menngenent Breach.

Mr. R.

,

notional Inetituie of neutel Eeelth,

Perklewn Bldg.,

Room TC~26.

5600 Tiehere Lone,

RookVille, Herylend 20852.

RIP-ﬁnAe73—22S

Lita:

E. Tonlgz

Dear Mr. Gredwell,

Enclosed is a reviled contract pricing proposal for the
study of neltrexono in “The Evaluation of Narcotic Antagonists“
in response to R!P~EIMH~HDA~73~225. Thie revision is in the
enount or $165,761 for 18 month: end repreeente en exteneion

of
m

83M~h2~70-115.

In.ueking the adjustments requested in our telephone
conversation we have:

‘

F»:

deleted iteme representing EEG;
added e leboretory teohnioien

edditionel laboratory teete;

to: the

provided an ellouence for trexel for the four
edditionel deye each week for eubJeote to
extend the clinic daily while on outpatient

statue;

end. increeeed the nuree from heltbtine to
full~time to provide edditionel weekend

coverage for the added daily delivery of

neltrexone.

ﬁe underetend thet the ProJect Director bee ree¢umended
edanetnente in our permit. and we agree to comply vith his
reoounendetione, subject only to the review of our local COBIHB,
ehonld that be neeeeeery.
Thank you

for your eoogeretion.
Sincerely youre,

HF/i:

EMIe

MI!

rink,

McD.

Professor of Peyohietry

�</text>
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                    <text>WWW..ww—u

I

Tmﬁh

Juno 1h, 1973

23x. Egg-1

{mall .

Dirwtor or

Have ,

New Year}: NBC

M].

h.

News.
NtY.

Dew Earl,

m

I regret vary much- missing
tom. but I have
and
lecture
Boston.
Drugs
in
prior
I hope
cum
t
you enjoy your stay tony.
After a. numbcr or your: mm has issued a. manual
call for Moratorium to develop 3 long-acting memo
antagonist. New that the incidence of opiate use um
to M declining, u. main multimillion 6.911ch error: in

being launched. l’arhcpn it would be useful for thc
may methadone dependant pmonn tint new dot tho America:

“‘0‘”!
My

best with“.
85.11%me your: .

ﬂux

mm.

14.1).

Professor of Pnychigtry
gar/1.1

�</text>
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                    <text>7383—702

»

June 15th, 1973
Dr. Michael Boaubrun.
Department of Psychiatry,

University of West Indies.

.

Mane,- Kingeton, Jamaica.

Deer

nicked.

The studies in Athens are proceeding very well. The
hashish user sample has been studied. thoroughly; controls
have been identified and studied; mime investigation: using
inhalation of hashiah acne-«113.4 and marijuana have been
commend; and we are new proceeding with on acute
withdrawal study.
The

quality or the. work is. excellent and

we

on

confident that» are con docmnt a range or chronic. effects
for «mm: as well as clearly showing the development

of tolerance.

to confine the"
It he: become even more urgent
end
poyuletion in
your
emu.
an ideal case for this purpose. It bu been more then

oboemtiom in another

W

«amassed thitwork. and I am writing to enquire
new be “awaited; or perhaps you
them
under
other wepieee; or your interest
undertaking
an
has ironed. end that my further efforts Wild be of little
to
for your opinion
inﬁerut. I would be
mother it would be fruitml for us to attempt a. renegotiation
of our relationship and, the potent“). funding for this study
niece

we

whether

thou audios

mum

a

wow.

Meanwhile, we have heard tint some of the meteriel
from your first study he: been presented. and I would be
met grateful for eopiee of
report: or pinpoints which
oould be
at
to
this time. We would like
us
tunable
give due credit to year prior work in our forthcoming

m

presentations.

w

to

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From

”19¢;th
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June 15th, 1973

this lotmhud. you will act: that I have
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14.33.

Professor of Pay-emu”

�7383-68h

Jun.

161:

, 1973

Jam J. 30111:“. 8.1)..
Marcher. Btu-m 01’ Month Gunﬁre].
State a! Key fork Department of math
‘

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mm Ava.
Albany. LY. 12266
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ballistigr
{to ban appliéd far a emanation to outage in
T
Clan Basemh‘ and. instruction“ nativity using
sandals I watt-oiled MIMQS; We. submitted a. general
«mum of our man: with this invitation.
Bug: Dr,

In

melanin;

human“ of that application. we are
mm
copy or the work mutant“: for contract

a.

vhmh describes the ma.“ which is ongoing
Wenmus
gt. the want tins and for we}: we!) cartiﬂeﬂton 1a
remand. In Melitta-u m the unwitting a any: of
t form}. propoul for m: wk beginning Jun 25, 1973,
mm: is an Manama of mhzﬁvmns.
Sincerely your: ,

Pink. mm
It:
Protauor of

Psychintry

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                    <text>\.\

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‘

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Loyola undies]. Cents“;
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»

am

Juno lhth,‘ 1973

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plundthat my mama Heinz-om:
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is quite nu: ma your request in:
to {11.6qu the feasibility of arranging
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Inch an election.
led

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author than tax-«ins in Writing. or trying to
discuss this: from a climb, is than an uncanny for
to b0 1:: this an: 171‘an tho next few loath” It
so. I would suggest you one and visit tad give us an
opportmity to uncut- t maublo program. Please note
this in a an
and the it my not
tint
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to we
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                    <text>7383-697

Juno
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Manley

FRO“:

Mt!

summer:

If

VA

“.13.

VA

aspen

Jacques

811m

projects:

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-

1973

r. 2011", NJ).

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1913

For

link,

25, 197'! Jun:
m. Jammums.

or motto
Mutton
38K heave—115
25 . 1973

~

(h) Colloboroun “may of mm - Methadone.
VA oollohorotiw study, no additional
funds to dutc-

studio: mo innovativo tenements of opioto
aemdonco, portioulnrly substitution by methodone and
Tho

motto antagonism using avalanche.
using wpillopnphw, urinalysis,
tmtunt
hovo boon
heroin

lemon-swig and
Evolution: of
and

intrnmm

challenge-

introduced.

Project staff inclusion

Donna. Sun-on. M.B.B.8..
Don, 3.3.3.8.. and Julian Rubin. 14.1). or the
(6%) . undo:- tho supervision of tho principd

ﬂounder

me

24!.

investigator. It: Fink. n.9, . Prof-nor of
MY - Stony Brook and V4. consultant.

thiotry at

Dr. Pink hon boon appointed to the VA-BAODAP
Gallant-active LMH-Mothodono Study Coordimting Council;
and elected Prooidont, American Payohoyothologiool

nonunion.
VJ.
ill/1.3

To date. no publiootionn have been den-1nd from
"study program.

thin

�</text>
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                    <text>'wul‘w-Pw-mw—w

7383693

m-e—

«WW.am.

“m-‘m'ﬂn‘ﬂ’vwx.m~vv..,.v..w

June 13. 1973

Professor 2. Keohoulan.
Dept. o: Netursl Products,
Hebrew University or Jermain.

The School

9.0.

or Phermeey.

B. 12065,

Jerusalem. Israel.

Deer Rspheel .Both Al and

I

I were distressed by your letter of

may

30th.

letter of Her 10th indicating that you
in the States for s for days, but during thst time I
see in Mono. end therefore did not reach you. Your lster letter
is inaeed surprising, and I very much rep-at thst this sequence of
events hes mom-red. Ae you elresdy know. the Netionel Institute
of motel Heelth with snow widen“ he‘s finslly end reluetently
eased to maerteke s. program of. developer“: of e longnseting
sntsgonist. There ere new contract sppliestions, I on told.
end perhepe the eonittee will arrive at a. legion]. decision bssed
on the credentials supplied by the Northeastern poop.
I believe that Al will note some mention of your distress in
his next discussion with the people st
had rseeived your

would be

m.

m.

wit
It is of interest to use that may
experience
or interest in drug abuse have indeed cone into e field during
the pest two veers . end new with fine reputetions have written

moire great sppiieetions

which committees

,

st

m hsve funded.

I hove been saddened by these events. in yertieulsr b1 the menses
that new who heve come for monastery gain will probsbly contribute
little. Also. because there is so mob honey, science seems to
here been dieplsned by polities. Beosuss I here been becoming
increasingly Wfortsble in this environment . I have foenssad
more of w sttsntion on the problem of herein and behavior.
particularly with psychoactive substsnees . and put the drug sbuse
problem sside.

‘

Our studies of hashish users in Athens is going very well,
end Dr. Btethnis end his coworkers should have s creditable

doemnt demonstrating the leak of signitiosnt effect of chronic

..

- .—.

"mum-e...

�Pref. a. Micheal”:

~2-

June 13. 1973

Mill:
an. Ind 32: mm degree of tolerance to very high
doses of mush. (Men make 130 I; arm-mm equivalent
fam- tilu t «hr with plum. and without intmuption of their
par-fame).
I hope than will be tn opportmty to visit you in
(formula some time soon. In 1:11. m1}... should you cm
hack to the Unit.“ Stat.” plan In no km. and whap- to
em ”man to have dinner
My

bent--

”my“.

W3

Mum»
‘

”/13.

"

,:

yam-n,

Fink. 1M).
Fatwa: of thn’ary
lax?

�</text>
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                    <text>%
',"1

Wygqu-w-v-

7383691

June 13th, 1973

Virgil A'o‘ Ph¢0g ”.D'I g.
President. Hediaal Atr:1rl.

V10:

‘

ALEA

Corporation‘

Boar

Virgil.

,

950 Page Mill Read.
9310 Alta, Cﬂifornil, 9530);.

I havu road the proposnl
antagoniut’with grott intcrtitw

tar

It

narcotic
;1:long-acting
a drtnntic ind

protonsignsl prcucnma$ion‘ The introduction 1:
toehnieully and losieally carruct - Sadned, your stuff
has done an excellent 36b in sttting the problau.

furtharnoro, the style of pretentgtton of clinioul
tanting in sodsta and apprayrintc to a preposal which 1:
rbcusned on the duvolopnnnt o! s dcvico. You indicate
:3 mittens»: or the importcnnc of clinieul testing. :nd
yet leave open tbr the contruetins usency to select it.
taut: of testing.

I ﬁbula be optimistic thnt should the committcos
be 10:10“: dbout this npproach, thcy ﬁbula conaiéor this
applieution favornhly. I would be pleased to tactic you
in nu:

that I can.
belt rugnrds.

way
my

Sinnnrcly yours.

ﬂux Fink, M.D.

Pratt-nor of Psychiatry

hill:

�</text>
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              <elementText elementTextId="56852">
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                    <text>w—

1'vw‘wmmw m- W~"

.

«wins

(NW

w-

a."

'1'.

«V

yr
-W

WW

nrw—vy—n-Ir

"~16

7383695

Jun. 13th,
Mr. L. R.

Hines.

ﬁatMnmLa

Nutley. Hui.

Roeho

1973

Inc. .

0711.0.

Dew Len,

hank you for your thoughtfulness in tending me
a copy of “The Benzodiaaomnes”. I have had a chance
to read-1t and ham found it no“ interacting. The
biochemistry of these compounds ht: wparently been
worked out in considerable detail. As you my know,
we are: now in the 31611; of an "ﬁxation of tha m‘
and behavioral effects or bmaem and diatom.
In this study we are mutating blood levels at variant
the»: and I am optimistin that an should be dale to
contribute to the understanding of the role of the
on hum function.
13mm amound and its
-

v

-

'

mum
min. may thunk: for m thoughtfulness

.

airman): yours,

Mu:

Fink, 1M).
of Psychiatry

h-afum
Im/ 1.)

.-

W,—.

m «'n-m

�</text>
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TEE-685
June 18th. 1973

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June 1th, 1973

8W.M.Smitty at
IV” I.

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                    <text>Tm,

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MI?

29th. 1973

wwz'vmwvwgv’mrv-W'IVr—A)‘

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Donnld

M.

Gallant, H.D.,

Mme University

School of Medicine.

Papa-taunt of Psychiatry and Neurology,
1160 Tulane Ave. ,
Haw Orleans, Louilitna 70112.

.mu‘

r
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Dear Dan,

I very much angered year hospitality in New
I a: taking the opportunity to than);
yen for your effort on our behalf. I know hm: much
ml: 1% 1., and the «tundra! you not will be a. turd
cm to match in the caning matings.
‘

Orleans,

and.

My

ﬂanks. and

my

best regards.
Simerely yours,

.'V:'~"""!‘-‘Vu‘l

Fink, M.D.
m
Professor of Ptyhhistry

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    <fileContainer>
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                    <text>A
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731:111
29. 1973

HIV

Albay Dr. Soviet Akpiner

Celikkele Sakai

3/ 10 Hailey
Ankara, Turkey

Dear Dr. Akpiner.

I very much restet that I will be uneble to Join Dr. Itil
end yourself st the etert of the study of OR? 8063; but I look forward
to visiting you in Ankara later this eulner.
There is one udditiou to the protocol that would be most
In
our eneeyu of OR! 8063, we obtained sole blood couple. and
helpful.
were dble to correlate the EEG effects over e three veek period with the
that
blood levels or the nettbolite at on! 8063. We would like to
blood senplee be collected during this study. prepared es follavu, end
stored frozen until the ena or the study when I will arrange with you to
how: the total staple eiruehipped.to the 0.8.

at

the protocol, please add the following: At zaah vacation
0: Achcduud, pee-dug, and at the and 05 the (but and
med
05 autumn: (page 1). count 10 cc. blood in a dean tube;
To

mm mmmWAmMadwwc
max
in mew!

when an EEG

Wéuge,
(much hue puuLouALy

shipment

a mutated.
Should Lt

actuated at the end

been tab

be.

‘

(male,

05 the.

and atom:

1. Place

an additional Ample

pat-dang

WW

peeled.

‘W be

should there be unusual expense: incurred in

please discuss these with Dr.
My

best regnrde,

Itil.

end £8813,

thie procedure.

I look forward to visiting with you.
Sincerely yours,

Mex

cc: Turen

Itil

Fink, X.D.

�</text>
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                    <text>7333680
”‘1’ 29th .. 1973
Al Heisman, Ph.D.,

Pfizer Inc. .

Gretna, Connecticut

MAJ-9‘

I very

much

«mom your

of the drugawry
new drug identiﬁcation.

bun
seemed so extensive. that I
3mm
and to
an writing to thank you far
M10112:
drug interactions

at the

ECDEU.

33'

Your

for

u

ask whether you cauld make

your
copy

a.

an.

«0:1th. to m.

few years ago. Sun Irvin organized a. similar
at the ACEP, and I understood he mtcd to
u but I do not rec-.11 seeing
If he did
pal-Mp: there is room for mob o. volm, with

session
publish

A

it

not,
report- ,nmilur to

it.

then presented at

ECDEU.

w but roman.
Sincerely yours.

ﬂax

rink, NJ).

Profouor of Psychittry
Mir/13

�</text>
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                    <text>Mt? 91!. 19T3
Dr12mg

Ken‘b'

worm”:
Centaur,

Retinal

Salt Esta c1gggébunty Hamlin Dept.

1% East 611: south, 7‘
8:11.13ka @113, Utah 31111.
Eon: Boater aﬁﬁnnon,

‘if! @he gape: en ”Hareatie Antaganiats” requesﬁed

Ew'yeu will nab be avn11able un111 yubl1ahad by the
Eutiana1 Caun1in1en‘in the summer of 19?3. I suggest
yen vr1te to tEn cummias1on tar augmlqmanta, when
uwi?
.ainoerely yours,

Pink. M.D.
th
Prefosaor of Psychiatry
13/13

�</text>
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-«

-r.-.-_.1A,.wm...,.._...——~

m-w‘vv

“4”,...

w

n‘m

733-677

waf-

M 23156.. 1973

A'WV—w—y’m

W7

'Wrw.”

m,

“Paws”!

m-rw

Fur-m"

Mr. Gary Boycr.

cent» for Studies of narcotic: and Drug Abuse.
National Inwituto of mental Earth,
5600

31am:

bur

Mr. Boyer.

Lane,

wanna. Maryland

20852.

.

.

Wyn-«r

.

Enclosed

WWA-szJ

for" he

mum
500 arm a! ”13m plwaho.
of the

2.6%

uproot“.
11:

raving this

to receive

a.

cm be signed

-

is a. roqunt

mac-«1.1M

mums.

I

would

Inbound that

foa- hy Mrs. 837111;

u wait.

bottlu of

cutout tad

runner,

(I u: only in New York one
an «1.1
V111
be «nibble every day
any n melt. but the

palace).

Mm.

Sincerely yours .

nah
m
mensor' of Psychiatry
“O D O

M1113

Em .

�</text>
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                    <text>TwB-G’Th

“I? 1T“! .

W. Minn.

m“ R. J:

W

1973

61110:.

Contact: Moment
mama and Contmta

Brunch.

Katmai Indium of Rental Health,
Putnam Bldg. , Roan “YO—~26,
5600 Fish.“ Lane.
Rock‘dllo.

but

Mr.

WM 20852.

Re: 38!! h2~70-115

-

Well.

1

-

-'

22'

‘

Attached we 12 wpiea. of a formal application in

to m-m~m~73~223, «titled "Emlmtion of
name
Maﬁa Antagonists” . m: application is to be

command a, moral a! BB)! bib-76415.
New» of tho' that contain“. ammu- this
amputation u u preliminary mm“. mbjcct to modification
(1-: may) by the apps-mint. summation of the 8m :1;
Stony Brook. Ho rowan radar of this appliention, and

it is submitted to meet the W 29.
inﬂated int!» an.

1973 daadlinc

award: yam-a ,
Mu

rink,

11.1).

Mum- ot Psychiatry
10/13

:36.

o

�</text>
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                    <text>.,

"worn,”

7333~670
Mir 173k. 1973

,
.rr-v

lam-7711"”

migrrwvawgwt_wxxwvy

:mvrm

Thu Honarablo Lester ﬂblff.
House artiee Building,
whiningtan. D*C. 20515.
Dnar Royresentativn Wblrf.

During the past few your: the President has sought
support for discantinuing roscareh training fund... The
iamuet or thiu airbrt on rotonroh and teaahing in fur
roanhing. and Ropruuantuttvn Punl angers has introdnaed

logialntion to rcvnruo this Prcsiatnttnl decision.

I Ihauld

new 11k:

to ucliait your nuppart for

Sﬁko, "Tho 3:316nn1 Ranaaroh and Trainacnhip Act a!
1973". This bill would reutoro rosaarah and teaching
tillawuhipa with u) n ceiling on the tomnl umounta to be
HR

apcnt, b) a proviue fur rcturn at tvu ynars of service
tar avery'yuar of aupgortt and c) a limit of three years of
support. Such provisiana uhonld avuroann most of the
obaaetioas ta eh. yrsviou: programs.
This

bill

would

allav aantinned prograsa

anvulopnnnﬁ, through rcnenrnh.

at

1n

the

gator Ind more effective
drug: fbr treating various illnecnos and for $hc bent
appliastionl at drugs fur uh: traatunnt at patients by
practicing phytiainns. Thanh arc unttarl of aoneern to those
of us who eonsidnr ourselvun ‘3 clinical pharmacologiuta.
but in the broadsr View, this bill will :naure a continuing
flaw of renegrchers and toaahnrn for all fields of medicina.
Thank you

fbr your aaurtety.
sinaarely ynura,

ﬁnk. NJ).
m
Protesuar of Psychiatry
MF/id

�</text>
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                    <text>7383-4376
May

NW,

1973

Profuse): J11-1 Roubietk ,
10109? Labombory ,
Harem
melon ,

huh .

"\“V‘rul-P

‘

Switzerland .

Dar 51:1,

mvrnvv

nr-rv

1‘4

,

Volta has shared with me his experieneea at the
meeting: earlier this math. He was very much
impressed with tn. quality of work now in progress in
Europe, but Micnlarly with thud: which you and your
swarm: Dr. muses}: are carrying out. As you 1mm.
I have command to apply our period and povor upcctnl
and the complex autistic: assumed ”by Don
mania
Shapiro to the problem of defining drug effects.
Voita bulima that your mthoda min a. positive

m

contribution to drug chasiﬂcu’sien, and I am interacted
in visiting with you on one of w forthcoming trips
to Ezra”.

I plan to

be in Europe for this we meeting: in
and
should you be back in your laboratories
Harlem»,
right after the meeting. perhaps I cauld Arrange a visit
them. Alternatinly, I expect to be in Europe min
about October 25—27%. and I could. visit you hater. or

after.

Finally, would you have any reports written by
yourself or Dr. munch I would
copin.
particularly of thc report 3m presented which so

twists

1m..'.d 701%...

I hm mod

aw

W

ummory sixty

City. to the
In York
have
bought
I

miles east of

and the mantra". This
I mom heme which overlooks the
water.- It 1- much taller than the an. you visual, but
has a. special
at mm less than ten minutes

M
it

We

�Professor

Jiri Wink

~2~

May

17th,

1973

m.

from the University. Baum. Linda still hu two
to so in tho schools in Grant Rock, I will try to mat-sin
both homes. The girls are growing up - Rahal should be
going to college next. your. Jon is completing college
this month and is planning to so in Stamford for Wm“
work in seeing. He bu Mm particularly unrated
1n the geology of the desert. A: a. sidelina, he has
learned to fly, and mum and I are both pleased with his

progress and plans.

vary

Eartha. and the girls Join me in wishing you our
to you and to Narnia.

but

My

best regards,

Simmly yours.

Fink. DMD.
Professor of Psychiatry

Max

WI 13

�</text>
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                    <text>m—w—mmm—ww

-

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1...—..v

,«(u'mvnr &gt;\'

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7383-671

W 17th.

1973

Richard L. Teylor. 24.13.,
Apt. 202.
6621 Bonnie Ridge Drive,

Baltimore,

Md. 23.209.

Deer Doctor Taylor.
When

I reeeived

Proceedings of the

your request for a copy of the

we Conference. I

knew

that

it use

not available. Indeed. the documents have recently
been sent to the publisher end the volume "thobiology
or Com-ﬁve Therapy", editea by melt, Richmond
linemen, and William. will be published by v. H.
Winston and Sons
No

of Yeshington. 11.0.

ebout November, 1973.

other proceeding. are eveileble et the present time

until that voluee is published.
should you wish to obtain e different overview of
the EC? prone“. I ”agent. you look at the speciel

ism

of

Warner:

umber 1, February. 1972.
Thank you

I edited. value

for your inter-out.

Sincerely yours ,

’1“, ”OD.
m
Professor of Psychiatry
HIP/13

It,

~—.~—_-w.n.m.--...u n

r r,"

n—

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7333-675

my 17th;

1973

'ur.janay‘ubia.
003.3? 0611080 I

humility. mm.

M ”I Vain

-,

m

m

fmr
IIIIII' of Ayn-11 29th
I VIII to thank
I would bI very much interested 1n raving InoIhIr
IIudInI mixing with III, I In mm. It IhI prIIInI
to fund Inch I poI1I1II. II I hum
mm on
two yams IIIiIIIIII. I Ila-III IhII yam mad he Mutt“!
hum In 99901-1:me to
Io win-.1 mhool. Rheum
11111: Stony Brook
I would ho «lighten! to meet
Ibo kind of work Inn is going on
you III In Ihov
WC.
Rh1-1I

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am,
m

:3 but. wishes

turf

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�</text>
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                    <text>731:109

May

17. 1973

Mt. G. C. Knnznan
IBM

59 Maiden Lane

New
,

York City

Dear Mr. Knnznan,

.v
~

"r-w-uw

4—4va

._
:w-x.

v
vw

.-—~.

V‘W';

I would be grateful for your assistance with the two
enclosed statements sent this Association for payment. In part, I
an turning to you because I seem to lack a business office contact
in Haeaau~8uffolk.

is now increased from a monthly charge
lack an explanation for this change. Last
month, we did receive a statement marked for $0.75 and the note that
it not be paid. Can we get an explanation 7
1. Invoice F276765

of $32h.00 to $32h.75.

We

2. We moved the IBM 1800 from its location at the Rev York
Meaical College at S East 102 Street on Decenber 7, 1972. Each month.

I

have corrected the invoice

Installed at:

'

"-‘

‘
“12'7"

-n-"'n'"7.‘"""-“V"‘

.m‘mm'vmwmww

The invoice address

Department of Psychiatry
Health Sciences Center» Surge I
BURY at Stony Brook
Room 2310
Stony Brook, Haw York 11790

is correct. I

these invoices before
Thank you

in the appropriate location to:

we

would appreciate correction of
take further action.

for your assistance.
Sincerely yours,

1m”

TW‘S'WW‘WM'WF

mmbwwuw

Pink, M.D.
Eeceutive Director

Max

�</text>
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                    <text>TBI~672
M3?

Tuna

PK 319.

Ital.

17th. 1973

34.13..

Hheidiyekoy,

Istanbul.

Turkey.

Dear Turan,

I am leaving fbr Europa an June lat, and will be
in Athens until whursday, June 7th. At thc momnnt.
I an schodulad ta arrivn in Istanbul on the afternoon
of Friday, June 8th. It I mtintnin this schedule,
I would like to be dbl: to acct with you thtt attains.
I hold tn open ticket for Istanbul, Ankara and rcturn. and
ha?» set using the veekand tad Botany to upond with you
3nd in Ankara.
I should sign the contract fbr my house on the
morning of June lat. and than last: it and all its
prdhlums to Martha. In Athnna I can be reachnd through
Pratouaor 8tothnis,(6ka~2025. or 801.0891 (hunt). I
hep. your trip to the Orient and around the world was
caniting. and I 1001 forward to spanding noun tin» with
you. (I hnvt been nndblu ta dbtgin a reacrvution at the
Hilton for iriday Jun: 8th. Perhaps you can enquire
or nuke a reservation at tnothmr hotel fur an. Mhny
than!!!) I
Mb'bcat rtgsrdn

to Ellen.
ﬁincerely yours.

at Fink.
ul/id

MOD.

�</text>
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                    <text>7383~669
Mhy

17th. 1973

The Honorohle Janna Buckley,

Senate Office Building,
Washington, D.C. 20510.
v.

Dear Soother Buckley,

w

—-—~—»v,v.n.r

-wr"

my.-r-v——~.7Hm-—..‘_—..W_

During the poet few years tho President has sought
support for diaeontinoing research training funds. The
impact of this effort on research and teaching in fur
ranching, and Ruprosentativa Paul Rogora has introduced
legislahion to rovursa this Prenidential deoiaion.

I should low like to solicit your support for
56h0, ”The hationul Research and Traineouhip hot I!
1973”. whoa its oqnivalant is introduced in tho Senate.
HR

nv_'-

wrvnwrra

"ﬁlmy-u.

“rs"?‘r‘r

“V

-5

lo

.
.

._.

'v'ApWV&lt;"vr)-..«~WT"¢V‘.VM,.

This bill would raster. research :nd teaching fellowship:
with a) a ceiling on tho total amounts to‘he spent. h)
a proviso for a return of two years of service for every
or three years of support.
you: of mop-orb and c) a.
Such provisions should ovaroomh most of tho objection: to
the pruvious yrograml.

we

This bill would allow continued progreoo in the
devolopuont, through research, of safar and more effectivo
drugs for treating various illnonoen and for the heat
applications of drugs for tho treahnont of patients by
pruchioing physicians. These are matters of concern to theta
of us who consider ourselvns as clinical pharmacologists,
but in the broadar View, this bill rill assure a continuing
flaw of researchora and teachers for all fields of medicine.

.—

Thank you

n

.

for your courtesy.
ﬁinooroly yours.

'W‘m’I-nmwzlvvx

&lt;

n—

r
-

Fink, M.D.
Professor of Psychiatry
Mn:

W:

vaqun»

WW

.v

MF/iJ

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                    <text>7333-3701

June 15311. 1973
‘

Wan Itilg Md)”
meso'uri Institute or Payehieery.
51:09 Arum Street.
-

at. Main.
Deer

museum‘s. 63139.

Tue-en...

Eneloeeﬂ it e emery which I presented at the
menace course of me Teehmlosieta. The only stew thing
in Table 5, which in the new mite their. I presented et

the

ECDEU.

Hem

mm.

here 0:1
I expect Dr.
as I am:
him mt. the meetings in Boston We agreed that he had
misunderstood me. for I ma aid that every compound tint
we had tested has shown the am behavioral eerrelation;
only 01-63. fer mien we have em mime]. dete, but no
human evidence of efrieney,
to be tented.

mine

W bﬂt regards.
Sincerely yew: .

Pink. 34.1).
Profeeeer of Fayehietry

Mex

Ill/1.1

ﬁne.

�</text>
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Elmer Gardner, M.D.
Bureau of Drugs
Food and Drug Adninistretion
Rockville, Mhrylend

De”

M8?

11. 1973

IND

5210

A1.

The studies of fluphenesine at high dosage, undertaken
in St. Louis and in Istanbul, were completed in 1971. The studies
resulted in s number of internal menorsnde describing the effects
and some EEG and behavioral reports published by Professor T. Itil
of the University of Missouri.

The studies were suspended vhen they were completed; the
supplies of fluphenezine were either completely used in
the study. or used at lower dosage in the clinical csre of pateints.
Bo stocks of high dosage fluphenezine exist.

initial
IRD

5210

this letter, I an notifying Professor Itil that the
is hereby suspended; and shall ask him to forward to your

By

office, copies of the reports of the studies for your information.
Thank you

for your oooperetions.
Sincerely yours,
Fink. Mons
Professor of Psychiatry

MEX

mf/

'

�</text>
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                    <text>"

'-“'W‘

-

‘

"Hr-r“

-

'7‘wu-vww-r—w.

"-Mvwmmww

'17-,

«mow-uqup fm-v‘".

~

,_,

,.. “ﬁn.

.

“l“...w, _,

V...

i

w, ...._.. -. ,m. ”any“. ,.

,

73NY:107

Turon

May

11, 1973

RE:

High Dose Fluphenazine'
IND 5210

M.D.
Itli,Institute

of Psychiatry
Arsenal Street
St. Louis, Missouri 63139

Missouri
5&amp;00

Dear Turun,

I have been asked for a progress report on our studies
dose
fluphenusine by the FDA. Enclosed is a copy of
of high

their letter

and my

reply.

have terminated studies or high dose
fluphnnazine in this country. and that the supplies from our
special formulation are exhnunted. To complete the records at
the FDA, I would appreciate your lending copies of the reports
from Missouri and Istanbul reflecting on these experiuncen.
These should be sent to Dr. Gardner.
As

I understand,

Many

we

thanks.
Sincerely yours,
-2 '

a:

1‘

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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7383:108FDA

Elmer Gardner, M.D.

Bureau of Drugs-

FDA

Rockville, Maryland

He: Inn 6590

Dear Al,

studies of levomothedyl are continuing, and we
recently submitted documents notifying the FDA that ve have
expanded the studies to my new facilities at the VAﬂoﬂotthport
and SUHY at Stony Brook.
The report: of the initiel studies have also been submitted
to your office; but in the event that these have lot been filed with
this IND, I am submitting copies herewith. The initial report
appeared in JAMA 220:811~813, 1972; end the second is in press in
The

the

same

Journel.

Thank you

for your reninder.
Sincerely yours,
./
r

”44

/

_/,u n.1,»

Fink, M.D.
Professor of Psychiatry

Max

mf/
Enc: Levomethadyl
JAMA, 1972
JAMA,

reports

in press

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4

may

Daniel

10, 1973

Freedman, M.D.
University of Chicago
Box 2011
950 East 59th Street
Chicago, Illinois 60637
X.

Dear Den.

Enclosed are three summaries oi the proceedings of the
conference "Psychobiology of Convulsive Therapy", end s short
introduction for your consideration for the Anchivea 06 Genehal
Pbychiatdy. The introduction is scent to give perspective to the

texts

and proper

credit to the

NIMH.

of the submitted papers is scheduled to be
published by v.3. Winston &amp; Sons in the early fall, and will include
these summaries of the Conference. The publishing contract use
negotiated with Mr. Erlbsum with the understanding that concurrent
publication of these sunmsrics would be acceptable.
I hope these reports are acceptable. My best personal
The volume

regards.

Sincerely yours,
an

Fink. M.D.
Professor of Psychiatry
Mex

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                    <text>10 May 1973

Saynour thy, M. D.
Departnnnt or Puyehin&amp;ry
EhrVnrd Madicnl Babool

Fruit

strict

Button, Hassaahusetts 0212h
Dear Seymour:
In submitting the summaries to Dan Freedman for tbs Archives. I haw:
a$taapt¢d to mnet his publication style and find that many references
of the sun—Irv luck tn. last pngn or the c1tn$ion.

references. ﬁbula it be puuaible
I copy of tha rcﬁyped
check
citaﬁion lists for the complete
or
to
your
start
your
t
rutoronco tad couplets those? I: thay art cant to no, I can so. thnt
tbs corroetcd citations got to Lawrcncc Erlbanm and to Dan Friedman.

I

um

tar

Many

enclosing
number

thanka.
Sincerely your»,

an: Fink.

M.

D.

Professor of Payehiatry

“Viﬂvv

Enclosures

�</text>
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.0

..

""77

-7

,

1‘ ..i ux. .vq.-‘W_ar1.lw”o~ylmxlvimm«.1»an -i-h“~v*w,;~.*xwwwnuw__~-.--w— war-"mm

M...- ...

won..." Tran—y,

-

”w—wiwvv:

7

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,

fur" MW!

73M: 4‘7
9 May 1973

John

J. Belliani. J.

D.

8! State Bureau of Hercotie Control
835 Central Avenue

Albany,
4

New

Dear Mr;

York 12206

Belliaai:

licensee for reeearch in schedule I and II to V drugs, as wall
as an invert certificate for schedule, at my office at 5 East 102 Street
in New York City. I transferred cone or my work to a new location at the
State University of New York at-stony Brook, and since February I have

I hold

BEBE

attempted to Obtain certification here.

for certification at a second address, we
notified belatedly that examination by your office was prerequisite.
reconsted examination by your office and early in April, your representav

After filing requests to

BEDD

wore
we

tive,

Mr. Conaolino examined

application forna

When we

order,

our location and kindly completed the necessary

on April 13, 1973.

enquired of him, on April 26, he indicated that the papers were in
deliver them to the appropriate agency in Albany on

and he would
Monday, April 30.

not hearing from your office, I called him today and was told that lie papers
have been forwarded, and that I should hero patience. In checking further, I
called Mr. Leonard Valeria, his supervisor, who indicated that he indeed
would have to approve the applicatiOn, but that the application had not
reached him as yet, and that I ahonld have patience.
Considering the excellent reputation of your office for efficiency, I am
surprised by this delay and I would be grateful for any assistance you can
give no in obtaining the necessary certificates. Our work has been delayed
many nonths, by our desire to abide by the law.
Many

thanks for your cooperation.

Sincerely yours,
Max

Fink,

M. D.

Professor.of Psychiatry

Manpv

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                    <text>7383:666

May

8.

1973

Jules M‘ssernsn, M.D.

6 South Michigan Avanue
Chicagc. Illinois 60603

Dear

Enclosed is an edited proof of tbs contribution to thc
ncxt volume of Current szghintgia Tharagies. There are a few

g

E

minor corrections. chiefly in the eitaﬁionn.
Thare are two
omissions. however. which I am bringing to your attention.

E

'

3

E
z

g

Jules,

ditttrant

,F\
,

The footnote, assisting thg reader to separate the
forma of long acting methaaels is amitted, and I

has. added

it.

The credits doletcd.uy geknowladgement to my co—
workers, and to the funding agencies which have supported this
vamk. I an incluaing skate with the request that these debts

be anknowledged.

volume.

My

thanks again for inviting

my

participation in this

Sincerely yours,

max Fink, M.D.
Professor of Psynhiatry

�</text>
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                    <text>754’: /0¢
MR?“

318 Department

T. 1973

of Hedth

Bur-m of ﬂax-cone Control
8% Gentrtl Avenue
Albany. Rev York
Gentlemen:

Enclased is my cheek in the amount of $10.00 for 100
sets of triplicate prescription forms, for preteribing subdue II

drugs.

My BKDD

amber

is

AF

1732103.

Sincerely yours.

'2

Fink, NJ).
Professor of Psychiatry

343x

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                    <text>731: 3.033

W 7.
m. Inwanca

13:le

v.3. Hunter:

a.

Hawks-1:19:31;

1511

K

1973

Sons

Street. m1.

wuhizwbon, 13.8.

20005

Dear Mr. Erlbnum,

Enclosed is the introdmtion to the mime by Martin
Kata. This represents the last. I'm-ml (”went for the volume.
lacking is the list of participants and their affiliatiam. I
have written to all the authors and asked that they sand me.
by return mil, edited titles; mad I have most already in hand.
This submiasion should make possible

a.

better

size of the valume. and the time course of
«that. omtheI will
call you later this week to see where
pumaauon.
we stand.
Sincerely yours,

Mu Fink. Mm.

�</text>
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                    <text>Mty

7,

1973

Harold Mnilullﬂ. M.D.,V1ee—Chnirmnn

Narcotics Addiatinn Control Commisaian
less‘arnaduuy
Nun

thk.

Nan-Ybrk

10033

Baa: Hiﬁbld:

I have Joined tbs iteulty of thc Health Sciences
the
Univaruity of New Ybrk st Stony Brook. Effective
It 1973 State
Roanick ha; teeuptud full responsibility,
Dr.
Richard
Int,
under thy suporviuton of Dr. ﬁltrud M. Fraudmnn. fbr thn scientific
3:9Icta of the contract bctunan tha Narcotics Addiction Central
Commisuian and the Nan Ybrk Medical Callas: {by thy study of narcotic
Intngnntsti and m-rijunnn.

As you miy knnu‘

Cantor

th

At Dr. Pruadmua’l request. I will continue
as long ts 1t 13 mutually antral.

ta assist Dr. Rennick for

For record purpesaa I unuld suggest that yen notify the various offices
that all communicatiaan be diraottd ta Dr. Freedman; axeept for theta
and these ohauld be sent
which would ardtnnrily be d1r¢ctcd ta mu
Raw
B.
Mbdicul
R1ch¢rd
Ybrk
Dr.
Roanick,
to
Callegt. 5 Bart IDan Strict,
Haw Ybrk. New Yank 10029.

..

It

has boon n.9130surc to wank with yau than: many years and I hogs
thnt it will bu poaniblo ta rouontablilh a wanking rulationuhip through
Dr. Yallas at Stony Brnok. my best personal regards.

Sinauvaly,
mfajr’

ccznr. Richard
Irvin B. Schwartz

B. Rulniek

Mix

Pink.

M.D.

�</text>
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73832102
May

7. 1973

Professor Heinrich Klﬁver
Culver Hall
University of Chicago
Chicago,

Illinois

Dear Professor Klﬁver,
was most kind of you to send me a reprint of your
introduction to the volume by Schultes and Hofmann. It is a
delightful history, and your essay stimulated me to find the
volume for my pleasure.

It

Since our last vriting, I have devoted my time to the
clinical problems of narcotic antagonists in the deconditioning
of opiate drug-seeking behavior. One compound, cyclazocine, has
been of special interest, because it is a most active antagonist
to heroin, and yet, in its use, stimulates a variety of illusory
sensations. These can be blocked by another antagonist, naloxone,

some interest. unfortunately, most
on clinical problems, on ways
focussed
been
have
of our efforts
and not on the immediate
in
behavior,
to affect a long term change
The study
compounds.
these
psychological events accompanying

and

their interactions are of

has permitted us, however, to explore the acute physiological

effects of heroin and also of different forms of cannabis. It is
important to realize that the drugs which are most commonly used are
shortthose whose effects on the brain are immediate and quite
2~h
minutes;
of
matter
heroin
a
is
of
lived: the desynchronization
short.
cannabis
equally
the hypersynchronisation of
satisfying feeling for a teacher to
realise that his students are productive, and that his ideas of
been of influence, beyond the immediate perception in the
classroom. My congratulations, and my thanks for your kind
.

It

must be a most

remembrance.

HAW“

.m-qu-

Sincerely yours,

w
n.

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>rw‘

an»

‘I'm"

Ir
-

n...

q-m-

—.

.»

up.

».

wmwv—q v-vsanw-w rum

m1’4m

"W_...,,

av" .

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avg—P? .. .,

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7

YEW.) mm~

m.

7388:0993
May

Burton Angrist,

M.D.

York University College
550 First Avenus
New York City

New

5. 1973

of Medicine

Dear Burt.

I

have rs~rosd your
interesting. I an vriting

report on CLllo,393 and find
to raids two suggestions.

it

most

In your experimsnts, you seensd to allow the sessions to
proceed for many hours; and in the discussion you note that the
was this
effects of this compound could be blocked by noloxone.
2
The
implication
effect tested in man 2 sad. if so, did it block
wonder
why.
and
I
not
was
tested,
was that it
The similsrity of this compound to storphine is indeed
striking. Tvo years ago. when I became interested in very potent

use.
opiates, I obtained a supply of storphine, which I did not
nsture,‘
similar
of
a
undertake
sons
trials
to
I would have no hesitation in supplying s fsv mg for your use.
My thanks for letting me rend this interesting rspbrt.

Should you wish

Sincerely'yours,
Imumm‘mvc’

'I-I-‘W'W-w—awv-w-w

1‘

""Wwvwrw

5"
‘
"~

‘
"'
"

'
“m"

mm:

“ain‘t-u

uwvr

wn-

wr

Ms: Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>7383 t 665%:

my ,
14

1973

Virgil Pinon, K.D.
Alan carparution

950 ?usn Mill Road
Pale Alta, Culiturnia 9h30h
ROI!

Virgil.

EncIOch is a slightly odiﬁad varnion 0: tbs applicatiana
aha tun royorha for ynur tilts. Bus is the :uunnry of our nalomnno
punncte «spurious. (thin in unsublishcd); thp uoeond is the summary
I wrote tbr the Mhridunna Commission tad in its reference: it contiinn
tbs latcst I could find an at tun months ago. I have ehaekad n tar
a! ﬁhn eitaiions run urn lauking.

I

um

ulna enclosing a eopy of

my

curriculum viii». fur

to dbstract in the upproyristc pines in tho application. Shauld
you'wish. I Vania be pleascd to be listed as a consultant to the
proaact. Shaula you yisn to ham» pariodie meetings in an. planning
of tbs variant phases of the yrodeot, uv'yarticipnxion eeuld bu
liltod in the expanse budget at truvel plus eonsultation tee.
in ninil:r vunturcs w! hnvu rneoivod $200 to QBOO/day or same
fltt figuro fbr the year. In this proyousl, listing 3 consultant
a&amp; $1200 to $1600 the first year would yrdbdbly pass without cougluint.
I trust thase note: are uaotul. Good luck in the
ybu

product.

Bineeroly yours,
Max

Fink.

M.D.

Praia-nor or Puywhintry

�</text>
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                    <text>7&amp;I-884
ME?

Kr. Lawrence Erlbaum,
Vieo—Prosidont,
V. K. Winston &amp; Sons,
1511

street,

3. 1973

Inc..

N.W..
washington, D.C. 20005.
K

Dear my. Erlbaum,

Enclosed are three sets or dooumonts for tho new
volume.
#20.

Clinical Progroas in convulsive

Therapy

is report

.l

w-uv’.

1—.

-r-—Ann~w

umqu,’uw

w—uv—p—mv-z’arr

W‘wrnww

1
v'r

-.

rrrrp-v'

a

wwwuvv—wa

-.

vmmmm-w

wrmm—aq-mx.w—mmupmww

1-

my”

.‘mn'l‘rgsv

:u

Irv‘cﬂymirﬂ"!

After submittﬁig, the report by manual: and William,

in relation to the summaries written by Katy and
myself, I made some changes in this summary, sent tham
to MoGaugh and Villinmn. and have gust roceivod their
opproval for the changes. I: you will compare the draft
in your hands and this draft, you will find that the
changes are essentially in the first two pages, and
thereattor they are minor.
and

1 am also submitting a coyy of #15, the article
by Koran: on multiple BOT. I am enclosing two copies:
one as revised by the author, so that you can see where
tho small ohangiu wore made; and a rotypod copy which may
not. it easier for your editor. These changoa wore
requnotod by mo, insofar as on important report concerning
multiple EDT appeared in tho Fobrunry, 1973 issua of the
Anoricon Journal of ?sychiatry.
Only looking at this moment is an introduction by
Dr. Ritz. I visited him in Wishington yesterday, and
he agreed to send it to no boforo Friday, indicating that
the delay was in port occasioned by the necessity to check
with sons of his superiors.
Ono

answer,

the

1973

This

tachnioal problem which I did not know how to
way to refer to other articles in

is the proper

I have worked thaw as
and "this volume” in the citations.
arbitrary, and I would ask your editor to not a

noon volumo.

in the text,

is

more acouptdble

For conveniouoo.

style.

�w.

Immense Erl'bmm

this

We

are

now 99$ up

~2~

ta date.

month. or early Jung,

than!» hm

when

mdvould like

May

I

3. 1973

Except for one weak

V111 ha

in

Rumpus.

aimerely yours,

Ma: 11:31:, Md).

Executive Director
Emu.

later

tomt v1thyou, 01-er

um edited drafts at year earliest conveniences.

ear/1.3

I

�</text>
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                    <text>7383-662

William Guy. Ph.D..
ECDEU Data Analyses,

Bioaotrio Laboratory.
11501 Huff Court.

Konsington.

MR.

20795.

Door 3111,

Enclosed is an salted report of ECDEU unit 006.
also pleased to enclose tour RPﬂ’a of ongoing
studies.

I

am

Insofar as

my

unit is

no longer

at tho

Rev York

Meaionl College, but now fully installed at Stony Brook,
I would be pleased if you would continue to use the
designation of the unit as 066, noting that the new
address is that at Stony Brook.

for the firot output on the ECDEU data
and I agent some time raiding
Despite the variety of populations and the large
it.
numbers of subject., many of the cells are quite small.
Tho project is indeed a many your effort.

bank.

Thank Ron

It is interesting.

Sincerely yours,

Fink, M.D.
Profosaor of Pnyuhiotry
Max

ur/ia

Enos.

�</text>
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                    <text>7353—662

Key

Kety.
SW
Jeane: new,

1.

1973

14.1).
1711.1).

Min Ken, NJ).

Deer Seymour. Jim, and Martin,

I hue received an «gushed plane cell from Tom
William in response te w letter announcing the full
ennui-110:1 of the articles from the meeting to the
publisher. He enquired u tn whether indeed he "had
been and from the editors". Hot knowing how to respond
mediately. I indieeted that I ma consult you.
I do not recell the compact which Tom is referring
that in editing this velm we did not
to. I do

m

that, in truth. his pertinipetian was
limited to representing the Clinical Research Breach
at the program eeuim.
«1.1 on him end

If there

in e

mi: which I

may be

neglecting,

grateful for e ruinder free any of you. In
the ebeenee of each In reminder I would be inclined to
learn the
u they ere. I an grateful for

I

would be

m

mwnte

advice.

sincerely yours.

Fink, HJ}.
Profeeeor of Psychiatry
Mu:

16/13

�</text>
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