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                    <text>January 5, 1972

To:

Alfred Freedman.

FRUH:

Max

SUBJECT:

Proposal for Medical Students, Chavez and Schwarzfarb
for Cannabis Studios

M.D.

Fink, H.D.

The attached protocol has been reviewed and is feasible.
However, the taking of blood samples in volunteers requires
special care and will interfere with their cooperation. that
and I believe we should pay ”a bonus" for blood samples.

I.

Will you approve

2.

From ﬁn 18172, may

3,

May

this study?

vs allocate 3300-400 to pay
those volunteers for their cooperation?
In xiv! these

raquoated?

men and Dr. ﬂoodles

(They are
Thanks

MF:ig
Enc.

available).

the chemicals

�</text>
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                    <text>1%-“. w:- gun‘s." Erma,”

.,

.

.

.7, V‘A'

.

‘n

ﬁrwwu— rmu-AM .u.

.

.v-

,. "7117'"

.v,:v-..W mum-w-—w--.-—rpvav.—~v.zu~-.-w—

-—

wry.» nuvm-w-w-

'

.WW

ymWVw-W‘VW'MN—FY'

wan—"pm”

mummy-rt."

-..,.

vw.’

,.

.‘rw'wum

”me

v-rr

7:me

wmwmm‘wﬁrw‘w

January 4, 1972
Henry

Brill,

M.D.

Pilgrim State Hospital

Brentwood, New York
”mm-w

y-r

Dear Henry,

-Wrw...~w_

w
v

.w...

and

it

may

Rhea Dornbush brought

interest

you

as well.

article to my attention,
anticipate examining our subjects

the enclosed

We

in Greece with these observations in mind.

m'

my

best regards.

awrwwmm—vw

rm

1'

Sincerely yours,

—y-

"Wv-u-v-r,

v—wv-‘m—r'w

wwwv—r'

I‘mzlmrml

Max

Fink, M.D.

--

�</text>
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                    <text>January 3,

1972

Stanley Einstein, Ph.D.
Executive Director
Institute Eér tug Study of Drug Addiction

680 West End Avenue
York, New York 13025

New

Dear Stan:

’It was Kind of you to invite the participation of our
laboratory in tau Second International s'mgosium 0n urug Begundcnce
‘h
in Israel, Hay 28w31, 1972. it will be at honor to garticipaCC A.”
the panel on chemotherapeutic approacuos to treating narcotic addicts.
We will be able to éisCusa our experiencea since 1905 witn cyclazocine,
naloxone, £~alpua~acotylmetnadol, and methadonc; and we then snould
also Have some data on too newest antagonist formulations, naloxone
pamoatu, £~cyclazocine and BC 2605.

It will

participation

be

funds available for

with the

necessary,

h waver,

for the expenses of this
there being no

to be defrayed outside our Department,

travel or maintonance overseas.

airlines, it will require
“Should this prove

(After checking

about $1,000).

practical for the Sponsors. I will sand

the requested abstract promptly.

Sincerely yours,
“8X Fiuk’ “.13.

Professor of Psychiatry

MF:ig

mug.“ n»«.s~¢.¢.‘d.».sa‘

..».

.ml'af‘uti‘a‘ 4m

'
.

'

n

.,

.

n’

�</text>
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                    <text>m

-

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.

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v

n.

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u :m.

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,

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January 3, 1972

wwmlwu'r‘vav‘v-ww»

Jaffe

Dr. Jerome H.
SAODAP

u

n

‘wn‘

The White House

Washington, D.C.
v-wwnm

»«

.w-‘Fvw—

rrwW.

Deer

Jerry,

In an interesting discussion with Dr. Cameron of the W.H.O.
in Mexico City, I was alerted to the possibility that Paul Jannsen
may have some potent and long acting narcotic antagonists. I wrote
to Paul and his answer is enclosed.

I plan to be in Europe en route to Athens between January

W—

v

I'Wr'

awrwrmw-qw

20 and February 10, and

will visit Janeeen at that time.

staff to accompany
It may be helpful for a member of your
have
indeed
some interesting
does
Jenesen
event
the
that
in
for
,
leads, these should be evaluated independently of any evnluation I

me
"I'm-IT."

"Jim-w"

may

make.

mun-r

my

best regards for a successful

1972

I

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

_

awwm—m”

1'"

‘7
mm.

-‘m'ﬁ'ﬂimrgrr

mf/

P.S. I am also enclosing e copy 01 a letter from Professor R. Mechoulem
of the Hebrew University. A1 Freedman interested him in the problem
of a formulation of naloxone for delayed release, end we supplied
him with some naloxone. In the event that you have e list of
potential research laboratories for this program, you may wish
to include him.
P.P.S.

What

is the status of the animal toxicology for

M—SOSO

?

.

u

.

.n— u..._‘.__.

”—77--

_

�</text>
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wwwmﬂwwvvrw-

——."—..Wv..v—.r~

«v.-

January 3, 1972
Dr. Paul Janssen

Janssen ?hsraaceutica
Beerse, Belgium

Dear Paul,

thanks for your letter of December 28. I plan
between
in Europe
January 20 and February 12, en route to
and
Athens,
will plan to visit your laboratories. I will write
Many

to be

or call and

make

the date more definite.

Because of the

potential importance of the study of
antagonists to the public health missions of our nation, I have
suggested to Dr. Jerome Jaffe of our special action office for
the President of the United States, that he send a member of his staff

with

me.

it is

If this suggestion is not acceptable, please advise

me.

his office that is responsible for the coordination of the
research efforts in the nation, any studies that may be undertaken will
be expedited if they are aware of the data at the outset.

As

My

best wishes for a successful

1972.

Sincerely yours,
Max

Fink, H.D.

�</text>
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wwwmﬂwwvvrw-

——."—..Wv..v—.r~

«v.-

January 3, 1972
Dr. Paul Janssen

Janssen ?hsraaceutica
Beerse, Belgium

Dear Paul,

thanks for your letter of December 28. I plan
between
in Europe
January 20 and February 12, en route to
and
Athens,
will plan to visit your laboratories. I will write
Many

to be

or call and

make

the date more definite.

Because of the

potential importance of the study of
antagonists to the public health missions of our nation, I have
suggested to Dr. Jerome Jaffe of our special action office for
the President of the United States, that he send a member of his staff

with

me.

it is

If this suggestion is not acceptable, please advise

me.

his office that is responsible for the coordination of the
research efforts in the nation, any studies that may be undertaken will
be expedited if they are aware of the data at the outset.

As

My

best wishes for a successful

1972.

Sincerely yours,
Max

Fink, H.D.

�</text>
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                    <text>’

June

Ur. Aobert

r1.

30 , 1972

Rees

Corporate Medical Officer
Drug, Inc.

Sterling

90 Park Avenue
Jew York, how York 10016

Dear Bob :

Enclosed
As

as

is

a

project report of the £~cyclazoc1ne studies.

soon as we have mare

outlined.

material,

we

will extend the stud“:

We also have received the concentrated dC-cyclazocine and
expand
our studies to include 3 (or A) subjects to 20 mg cycle:will
ocinc. Our data on 10 sag cyclnocinc (extending antagonism to #8 hours

-

25 mg

heroin)

is

being ”written-mp".

Thanks again

I

for your

antenna.
Sincerely yours,
Fink, 3.x).
Professor of Psychiatry

Hex
21?:13

ﬁne .

�</text>
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                    <text>fl..-“

_

a- ”a

,

”a

.

..

.

.

_

,.

.___, _.,w___-.. a...

we“. "my.W_n-_m_,.m~__.v~.r..__mr.,__ amm,ww~—w.-—".-.wwwrw_.—n.—wmmmm

.

I
5

June 29, 1972
Jerome Levine, M.D.
Head, Psychopharmacology Research Branch

National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Jerry,
The

are enclosed.

additional copies of the progress report for

MH—13358

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

V

�</text>
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June 28, 1972

Alfred

C. Ling, M.D. Ph.D.
Ciba-Gcigy

Summitt, New Jersey
Dear Dr. Ling,

Thank you for your favorable consideration of our
subvention of a report on GP—41299, to be published in
for
request
Arzneimittel—Forschung. I have written to the diitor indicating

this support.

I trust the report will be useful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Ref. 72-325N

June 28, 1972
Dr. med. L. German

EditionCantor

KG

796 Aulendorf

West Germany
Dear

Dr. German,
We

are pleased that you have considered the publication of

our report, Clinical Evaluation of GP—41299, with favor. We can
reimburse the journal for the additional costs of earlier printing,
and understand that the cost will approximate 1400 DM.
Enclosed

ability in written
translation, and I

on our

behalf.

Many

is

an English summary of our

German

would

report.

Our

is insufficient to provide an adequate
appreciate an effort by one of your editors

thanks.

We have found a number of interesting reports in the
Arzneimittel-Forschung which have been helpful to us, and we would
be pleased to share our experience with the pther readers of your

journal.

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>review- www.mmmemm

'w‘ww.

r

Ref: 72-324N

June 28, 1972
George L.

Fite,

Senior Editor

JANA

M.D.

Chicago,

Illinois

Dear Dr.

Fite,
As an

60610

addition to the

letter

on heroin maintenance whieh

you will publish, it may be useful to add three citations,
to give the scientific readers the opportunity to refer to the sources

you

indicate

of the statements.

At the end of paragraph 1:
At

the middle of paragraph 3:
and again,

l.

H

. . .

. . .

stuporous states." (1)

" . . . levomethadleZI) "

narcotic antagonists (3)."

Volavka, J. et a1. : Electrogrephia Effects of Diacetylnorphine
(Heroin) and Naloxone in Man. Neurogharm. g;587-593, 1970.

2. Zeke, A.

et a1.

Dependence.

: Levomethadyl in Maintenance Treatment of Opiate
J.A.M.A. 220:811-813, 1972.

3. Pink, M. : Narcotic Antagonists
1006, 1970.

I trust these

in Opiate

Dependence. Science 169:1005-

comments may improve the

letter.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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"

'v ., W- —--—- --——— .ww... --vn-

(“.mur

‘-""-"""‘l—-'

m.

...

..-«-

w'r-‘W'

a

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1

Grants and Contracts Management Branch
National Institute of Mental Health

5600 Fishers Lane
Rockbille, Maryland 20852

Re: BSM 42-70-98

Dear Leo,

Since March, we have continued the studies under this
Greece. we wished to sustain the 'team', and we were
in
contract
encouraged to do so by the interesting data they generated.
1. We authorized the following additional expenditures
under the subcontract:

III B-l

3—5
3—3

3-6

Salaries
Patient fees

Laboratory costs

EEG

costs

$

7200.
1500.
280.
310.

2. In December, 1971, we approved a visit by Costas Stefania,
M.D., the project leader in Athens. He visited New York and Washington,
giving us an opportunity to review the data and plan the next phase of
the studies; and reporting to the staff of the Institute of his
findings. He submitted a statement of his expenses for Athens-New York$825.
Washington-New York Athens in May.

latest

voucher (07, dated June 16, 1972), we
requested the balance of the funds under this contract, and found that
the balance left for overhead transfer was insufficient by $ 1,222.
3. In our

The

w.

.,,-

‘

June 28, 1972

Mr. Leo Sanders

-.

ﬁve—«.m-

-

Ref: 72~327

vu—w—rvw—m-v—pm—r—~—wv——..—mmmmmuw—Iw—_W.W,

._,

—-—-mwm—w w-vww.-m\~-w"Jr ~-m..W.-_..—.;-

«n—

pilot

EEG

data collected this spring

was analyzed

in

York, using machine time and personnel supported by NIMR grant
ME 18172. Such additional costs, as well as supplies, incidental
fees and travel, are not reimbursable.
New

My

negotiations.

thanks for your cooperation and understanding in these

Sincerely yours,
Fink, M.D.
Executive Director

Max

W.

m. m

—.—.m.......

�&lt;
.
v

MIMWV

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W,

.

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W

,

,

Wm.

r..— Y

June 28, 1972

42-70-98

Explanation of Costs incurred

III B-l

3-5

Dru. Liakos and Boulogouris ($400 x 2 x
Miss Kokkevi (psychologiat)
Dr. Panayiotopoulis (neurologist)
Miss D. Gefou (Social worker)
Mrs. A. Liakos (EEG technician)
Mr. L. Bassiakoa (Research assistant)
Smoking sessions. ambulatory,
60 sessions at $25

3-3

Echo-EEG

8-6

EEG

8-4

Travel

(14

at

3

pilot assays

$20)

costs (62 hours at $5/hr)
(Athens-Now York-Athens)

months)

$

2,600.
1,050.
1,200.
1,050.

750.
750.

1,500.
280.
310.
825.

-

‘nf'! 1m—'-v--’

�</text>
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_

Ref: 72-321 I
June 28, 1972

Michael Beaubrun, M.D.

Professor of Psychiatry
University of the West Indies

Mona, Kingston, Jamaica

Dear Michael,

I regret that

we

have been unable to obtain a contract for
at this time. It seems that one hurdle
is permission from the State Department

the cannabis studies in Jamaica,
that we cannot overcome directly
to undertake these studies.

Two weeks ago, when we spoke, I called Dr. Smith at NINE
and assured him of the answers you gave regarding the premature
release of the data. Not hearing from them, I called the contracting
division last week, and was told that it was too late to support the
study this fiscal year. I called Dr. Bunney, and after some discussions

with others, permission was given to fund the contract out of this
year's budget-- provided State Department approval could be obtained.
When the question was raised in Jamaica, apparently, the negative response
was sufficient to push the discussions to the next fiscal year.
Should you wish to proceed, I would suggest you enquire of
Dr. Jean Paul Smith or Dr. William Bunney, for an official interpretation

of the status of the application.

would be prepared to write a letter to the Secretary of
State, indicating that this Association has had experience in Greece and
that we have a good record; that it would be sad for the program to be
We

aborted because of the misbehavior of someone over
cntrol, egg.

whom we

have no

Incidentally, the 'worksheets' prepared by Dr. Smith, Dr.
Szara, Miss Carroll, and Dr. Petersen are most satisfactory, and I do
believe they were prepared (or are prepared) to see the program through,
if the administrative hurdles can be overcome.
Regretfully,
Fink, M.D.
Executive Director

Max

p. rm“-

, "1..“

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                    <text>ﬂag:

7v3w4/
June 27, 1972

J. Bellisri

Mr. John

Director
Bureau of Narcotic Control
State of how York
Department of Health
84 Holland Avenue
Albany, ﬂew York 12208

hr. Bellizzi:

Dear

I am writing with regsrd to Certificate 2984. issued to the
Psychiatry hrug Addiction Unit st 1901 First Avenue as s Class VI

-Registrent~ﬂethsdone Haintensnce Program.
We

Scientific
(1)

request re-designation as Class VI:

and Medical Research.
We

are not a methadone maintenance

Laboratories for

facility.

treat more patients with methadone as part of their
we also use group therapy, narcotic antagonists
but
psychiatric care,
(cyclazocine, naloxone. 355.), use heroin for experimental purposes,
(2)

and

We

do

test methadols.

hold

we do abide by FDA regulations, for methadone but also
for levomcthsdyl, nsloxone, L-cyclezocine. etc.
While no special regulations apply now. I anticipate that

IND

(3)

Class VI « HIP

will

be

restrictive

broader Class VI: Laboratories
Metropolitan Hospital.

—

and request re~designstion to a
both at 5 East 102nd Street and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Mex

Hing

�</text>
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                    <text>wvw‘

Ref: 72-316N

June 27, 1972
Robert

M.

Derman, M.D.

Veteran's Administration Hospital
New York City 10010
Dear Dr. Derman,

Enclosed

consultant at the

vitae.

is a completed application for the position of

V.A.

in

New

York, and a copy of

my

curriculum

In February, I was appointed consultant to the V.A. in
Montrose, and I have requested Dr. Harris of Montrose to send a
your attention.
letter indicating that this was indeed accomplished,to
V.A.
allow
the
to transfer
will
the
that
appointment
earlier
I trust
the appointment to New York, and avoid the extra effort in process-

ing.

Today, I spoke to Sam Kaim who indicated that he had
received support from SAODAP for the collaborative studies, but had
not received answers to his request for additional supplies of

levomethadyl.

My

thanks for your

invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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  </item>
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                    <text>Ref: 72-323

SB

June 27, 1972

Stanley Yollea, M.D.
Department of Psychiatry
SEXY-Stony Brook

Stony Brook,

New

York

11760

Dear Stan,

In checking the events at Montrose V.A.

this winter, I find
and that this
appointment was approved in Washington. Enclosed is a copy of that
application. Dr. Harris at Montrose has the file and can write the
that they did appoint

appropriate

I

me

a Consultant

in Psychiatry,

letter.

Perhaps this will make

have sent the same to Dr. Derman

methadyl study.

I shall be at Raquette

my

appointment to Northport easier.

at the Manhattan

on August 1 and

for the

lava—

for July. Should the
office in New York;
York. I expect to
will call your office that week.
Lake, N.Y.

occasion arise, you can reach me by calling
or writing to Genereal Delivery, Long Lake,

return

V.A.

my
New

Finally, the Greek cannabis study will be funded; the
Jamaica was sunk by lack of State Department clearance; and Jerry
Levine has yet to answer me-- I will call him at the end of this week
again.

Hy

best to all.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>.,_, ..

ww‘nw—

,

NV

.q...

,

;
g

E

Ref:

72—322

June 26, 1972
Morris B. Bender, M.D.

Professor

Chairman

&amp;

Department of Neurology
Mount Sinai Hospital
100

New

Street and Fifth Avenue
York City 10029

Dear Morris,

the Presidency of the
attended the meetings
It seems like
There are
found
and
discussions
rewarding.
so
of the Association
its
times when I regret that my path for research led me away from the
sure diagnoses in neurology and the clear images of the PEG and the
arteriogram. Surely, the squiggles of the EEG are a far cry from the
images on the x-ray.
But, I am also writing to congratulate you on your address-which was reported to me as a tour de fbrce.To have found an under—
standing of acupuncture in DSS is magnificent, and should the ensuing
research prove your hunch to be correct, it will provide a new impetus
to the research you so ably fostered.

ANA

hope

on your election to
so many years ago that we

Congratulations

I

that

regrets at not attending the meetings in Chicago-- I
will be able to meet again under such favorable conditions.

My

we

My

best regards to Sarah.
Sincerely yours,
Max

P.S. Thinking of the past reminds
Have these been discontinued

me
?

of the

Fink,

M.D.

Israel Strauss lectures--

�</text>
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                    <text>June 26, 1972

Jack Enroll, ﬁ.D.
The

Fsychiatric Institute

2141

K

Street.

H.W.

Washington, D.C. 20037
Dear Jack:

Enclosed

is

an

abstract, marijuana,

Habhion Md Tetaahydhocau—

nabinoi-l-% Eééecxé on tEG, Heant Rate, and mood, for your consid«
oration for the October meetings of the Psychiatric Research Society.
The report will daocribe dosenrelated EEG, heart rate and self~report
effects, witha focus on the relations of brain changes to behavior.
Suould you wish, Peter Crown will
by a song ”The Talking Killer Weed Blues”.
'l'he

illustrate the

presentation can be made in 20 minutes, but
for discussion. thereafter.

an opportunity

Sincerely yours,
Mux

Fink, 3.0.

Professor of Psychiatry
nF:ig
Enc.

mood

we

effects

would enjoy

�</text>
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                    <text>306‘7 . {so

géfaﬂuuggei

Ref: 72-3103

June 24, 1972
Derek Quantock, M.D., Ph.D.

N.V. Organon

Oss, Holland
Dear Derek,

We are progressing with our studies of intravenous OI~63.
In the present assays, we are using 15 mg doses, and for these subjects,
we are not finding the behavioral changes we obtained some months
ago. One thought, is the possibility that the samples I have left,
may have deteriorated; the other, is that our earlier assay was an

error.

I do not know how long it takes to make up, and to ship
additional supply of 01-63. But, I would like to re~do some
subjects at the end of this run, and for this purpose, will need
400 mg OI~63, in ampules of 10 mg each (if that is possible); or
the equivalent in the available lgfmg lots.

an

Many

thanks.
Sincerely yours,
Max

P.S.

My

trip to

One. I

Copenhagen

in

August

will write before then

Fink,

MD.

will include a side—trip to

when

I have the details before

me.

�</text>
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                    <text>M E M O R A N D U M
_——————.—~-—-«-——.

June 23, 1972

To:

Irv Schwartz

FROM:

max

Fink

I have reviewed the personnel previously assigned to the Psycho~
pharmacology Clinic and the various budgets. I believe the following
assignments provide for the continuation of programs, and a proper

utilization of funds.

Miss Sonna burbin and Miss Doris Giordano: These two research
nurses are devoting more of their time to the drug abuse service.
They are budgeted on 47—072~7. Dr. Levine has indicated that Miss

Durbin's time is now almost fully occupied in the drug abuse program,
and her assignment should be clearly designated as part of the addic~

tion program.

Miss Giordano has committments to the BCT program, and as Dr.
Taylor implements his lactate program, he may wish to utilize her
time. I suggest she be reassigned to the clinical services, and her
salary be paid from the new grants awarded to Drs. Taylor and Abrams
(to the extent they wish to use her time), and in part to that budget of the clinical services that support the treatment program,
notably ECT. The researdh aspects of ECT are no longer funded as
a separate project.

I endorse the request of both nurses (attached) for a review
The job descriptions should be modified slightly,
but both have exhibited a flexibility of assignment and a willingness
to assume reaponsibility that has been most useful. (Appropriate
of

their salaries.

levels

may

be $12,700 for Miss Durbin and $11,500 for Miss Giordano).

�Jr. Irv Schwartz

June 23, 1972

Pedro Gaztanaga, H.D.: He is working full time in the training program. It seems to me that if his salary is to be paid from
47~O72—7, we should assume he will have some relation to the addici
tion service. At present, there is no opening. Should the training
division wish to use his services, a fair guid pro guoﬁwould he the
assignment of residents, in rotation to 15A, on an equal basis with
residency assignments to 13A or 133. Lacking such a rotation, I fail
to see the justification for the use of these fund (47—072—7) to sup—
port clinical teaching away from the drug abuse treatment unit.
The remaining assignments of personnel and budgets of 15A seem
appropriate to me, (iiEia 47-072—7 and the personnel assignments of

the

15A

Addiction Treatment)units).

�</text>
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                    <text>June 23, 1972

Dr. S. kanowski

Freie Universitat Berlin

Nussbaumalee 36

1000 Berlin 19,
West Germany

Dear Professor Kanowski:

I

am

most

interested in your studies of blood levels of Perzin

years ago, Itil and I tried such a study of
failed to find a correlation but thought this may
butaperazine.
have resulted as much from the problems of measuring blood levels
as from the EEG measurement. In our studies of cycloserine, we did
find blood level n EEG correlations, and others have reported similar
correlations for lithium.
and

EEG

effects.

Some

We

The

reports

you requested, and some others which may be rel—

evant, are enclosed.
Many

thanks for your

interest.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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                    <text>Ref.

72—3115

June 23, 1972
Drs. G. Dolce and
E. Merck

K.

Offenloch

Darmstsdt, West Germany
Dear Drs. Dolce and Offenloch,

I am enclosing a draft of s recent report from this
laboratory, as presented at a meeting of the Drug Information Assoc-

istion.

August,

it

meetings in Copenhagen this
visit to Dsrmstsdt either
The meetings are scheduled for August

As I plan to attend the GIMP
may be possible to arrange a

before the sessions or after.
13-17.

Should such a
my

visit

be convenient,

please advise

me.

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>.

-

-

-

-*

'2'~*&lt;-&gt;~&gt;

--

mun—m

:w..w—,..wmu.w.m.w «w “n"‘m ”mm.wv—vw'v’-—q7vx~

p..." .,,-.....,.

,,_,__

a... m’lxk'ﬁw—W

1.“:r-,..,..~,~m~-_—.-..—r..~.r»w.r

Ref: 72-301N
June 23, 1972
Mrs. Roberta London
Contemporary Drug Problems
515 Oxford Street
Westbury, New York 11590
-Dear Mrs. London,

with

much

first

issue of Cbntemporary Drug Problems
interest, and found much that was new to me. I hope you

I read the

will be successful.

I have read the articles by Samuels and by Hochsteeter. They
are disappointing. Both are vague polemics, hoping that drug delivery
problem.
will, in some undefined way, solve the Opiate dependence
Neither provides answers to the technical issues with which we have
how to select patients; how to deliver drug safely;
grappled——
what about spillage; what is the duration of the treatment; etc.
More important, neither gives a clue as to their view of the etiology
of dependence and how heroin delivery will serve the patient, or
even society. Perhaps the third paper is better-- I should like to
read it if I am to provide a commentary, which I will do gladly. Can
you send me the San Francisco report ?
Yes, I should be pleased to participate in a panel discussdon
on heroin maintenance. I will try to bring to it the technical issues
which seem so complex, the problem, of 'after heroin, what then?', and,
so as not to be wholly negative, some alternate solutions based on
a different view of the etiology of drug dependence. I do not know
whom else you are considering for the panel other than the well known
advocates (Vera representatives, Samuels). Have you thought of some
official points of view, as that of BNDD (Haislip), SAOBAP (Jaffe or
Kramer), NINE (Bunney or Petersen), and the Marijuana Cpmmission

(Brill)

?

Good

know

it will

luc} in your

succeed.

new

venture.

It

serves a need, and I
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>EEEQEAEQEE
June 22, 1972

To:

A. M. Freedman, M.D.

FROM:

Max

SUBJEC":

Proposal, ”Effects in Man of the Chronic Administration
of Hethadone or Cyclazocine“

Fink,

M. u .

proposal is an experimental study in addicts, involving
tongue biopsis and infusions of methacholine and Zenorephrinephrine
to define cholinergic effects of methadone (or cyclazocine). The
study bears no direct or indirect benefit to the subjects.
The

proposal alludes to some experimentation data on the mouse
and salamander, but it is not clear wnat the relevance of these data
The

for

man may

be.

author treats methadone and cyclazocine as if they were
equivalent drugs. For example, what print data was obtained in
animals with cyclazocine?
The

The protocol is incomplete. How many subjects, how selected;
and by whom? What will be paid the addict volunteers? If not paid,
what benefit will they get? If any is part of treatment regimen,
who is responsible? What will be done with the samples?

infusions are cited but for the protocol, we do not know
how subjects will be selected; who will be present, what duration
and what criteria for the end of infusion. What of the blood pres—
sure effects? How will vagal effects be assessed and how will subjects be protected?
The

In

sum,

the protocol is incomplete, particularly as i
’

to the selection of subjects and benefits for subjects

ting.

�</text>
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                    <text>94‘; 11"}uu

M

June 22, 1972

Jerome Levine, M.D.

Chief. Psychophareacology Research Branch
National Institute of Mental Health
5600 Fishers Lane
Rockville, ﬁerylend 20852
RE: 'MH

13358

Dear Jerry:
Enclosed is a detailed summary of the studies in the program,
and Human Pégchophadmacoiagy, since January 1, 1971. This
should
provide summaries of the activities since the renewal application
summary. I have also outlined the studies now in progress and the
EEG

anticipated continuations after transfer to

Stony Brook.

There are some funding problems for the coming year. I have
developed a talented and well trained staff. Each is loyal and en—
thusiastic about the program and desires to move with me. What I
an not sble to face is that not all ~~ indeed only a small part of
those working on this program ~ are paid from this grant. The other
budgets remain in New York City. and I find that a realistic budget

to sustain the effort and pay for transfer and renovation is closer
to $90,000 for the first year
or until each a time as I can assign
their services, in part, to other programs. (Part of the delay in
sending this summary is based on my attempts to obtain additional
funding for this transfer).
——

Nevertheless, I believe I can sustain the program and I enclose
for the transfer year for $60,000.

on pages 20-22, a budget

�June 22, 1972

Jerome Levine, H.D.

I have also added eoee coenente for the continuing years of
to write, for I
the program. These latter were the moot difficult
ECDEU
supeort for this
believe that I should anticipate closure of
of the reviewers
comments
program, reflecting my perception of the
sustained this
have
period. I
for the continuetiou for this project
1960.
ECDEU
since
It is tire to
effort for PR3 since 1957 and for
in not
selfish
sometimes
I feel
summarize what we have leerned ~~
should
and
closure
hove
learned,
having ehered the details of whet we
provide the impetus.
however, the program is to go forward after three years,
197‘.
the decision should be anticipated in 1973 or the first helfendof that
consideration
There are two suggestions-which deserve your
the
of the Peychopharmecology Coumittee. It may be useful to have work—
a
end
convene
to
academic review you suggested in ﬂexico City;
of this diegrowth
the
in
who
have
participated
of
scientists
shop
relevant
to clin—
cipline. To both, we could address the questions
for
your pro~
ical psychopharmacology and provide additional inputs

If,

grommatic

decision.

Should

Stan Yolles

it
has

program to Stony Brook,
by the Inter—
administered
be
the grant

be pooaible to

agreed that

transfer the

Box 269,
national Association for 9eychiatric hesearch, Inc. (P.0.
is
possible
We
urge this, because it
Great Neck, new York 11022).
from
that Association if they administer
additional
support
obtain
to
the project.
I am most grateful for your support and interest these many
continue
years, and truat that your faith, and that of Jon Cole, will
to be rewarded by the results of these efforts.
Sincerely yours,

ﬂax Fink,

e'ieDe

Frofessor of Psychiatry

Hing

�</text>
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                    <text>June 20,.1972

William.Guy, Ph.D.

ECDEU

Coordinator

for Data Analyses

George Washington University

Biometric Laboratory
11501 ﬂuff Court
Kenoington, Haryland 20795
Dear

Bill:

I have read the various mohk~ups of scales sent on June 12.
the extant it is possible to review these outside the laboratory
situation, I have done so.

To

The
11

RPR

seems

satisfactory.

The FMS is an interesting addition. It is not clear whey item
is requested. These items may be significant only in relation to

concurrent illneoaes or conditions, and I do not see this information
recorded. But I see no difficulty in obtaining these data.
to use.

The 90138

is

an

interesting change,

TESS, Data Shipmont, and 93E

satisfactory.
We

should have

that

seem: easy

in using these forms,

Sincerely yours.

1,1“. 5.9.
m
Profoooor of toychiatry
“3:13

‘

are difficult to asSess but seem

littlc difficulty

anticipate thoir inplouontatian.

and one

and

�</text>
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                    <text>Juno 20, 1972

G.

F. Blane, Ph.ﬂ.

Reckitt &amp; Colman
Hull, England
Dear Gary:

Enclosed

is

an

official

U.S. import permit #3349

diprunorphine, for our annual assays.
Thank you

for

for your cooperation.
Sincerely yours,
Max

Fink, d.D.

Profnssor of Psychiatry

3F:1g
Enc-

’

15 grams

�</text>
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                    <text>June 19, 1972

click
32—15

Long

Book Binding Company

37th Avenue

Island City,

New

York

Gentlemen:

three volmes of EEG Gun. :Jemphyséoin which
would like to have bound in nation with gold lettering.
Enclosed

we

an

Lettering should read:
£30

EEG JOURBSAL

V01.

1971

30

'

JOURNAL

Vol.

31

19 72

EEG JOURNAL

Vol.

32

1972

Division of Biological Division of Biological Division of Biological
Psychiatry
Psychiatry
Psychiatry
A

confirming, purchase order

will follow.
Sincaraly yours ,
ﬂax Fink. 24.3.

Proton-or of Psychiatry

iii : is
Enc.

�</text>
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                    <text>Q,

l":

June 20, 1972

William Guy, Ph.D.
ECDEU

Coordinator

for Data Analyses

George Washington University

Biometric Laboratory
11501 Huff Court
Kensington, Aaryland 20795
Dear

Bill:

I have read the various mohk—ups of scales sent on June 12.
the extent it is possible to review these outside the laboratory
situation, I have done so.

To

The

RPR

seems

satisfactory.

My

an interesting addition. It is not clear wheytitem
II is requested. These items may be significant only in relation to
concurrent illnesses or conditions, and I do not see this information
recorded. But I see no difficulty in obtaining these data.
The

to use.

PMS

is

The DOTES

is

an

interesting change,

TESS, Data Shipment, and DSE

satisfactory.
We

should have

and one

that

seems easy

are difficult to assess but seem

little difficulty

anticipate their implementation.

in using these forms,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming

and

�</text>
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Click Book Binding Company
32-15 37th Avenue
Long

Island City,

New

York

Gentlemen:
we

would

Enclosed are three volumes of EEG Cﬂin. MauKOphyA£0£., which
like to have bound in maroon with gold lettering.

Lettering should read:
EEG JOURNAL

Vol.

1971

30

EEG JOURNAL

EEG JOURNAL

Vol.

Vol.

31

32

1972

1972

Division of Biological Division of Biological Division of Biological
Psychiatry
Psychiatry
Psychiatry
A

confirming purchase order

will follow.
Sincerely yours,

Max

Fink,

M.D.

Professor of Psychiatry
Ming
Enc.

�</text>
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                    <text>June 16, 1972
Walter Essman, Ph.D.
Department of Psychology
CUNY-Queens College

Flushingn New York

Dear Walt,

Enclosed are two checks from the New York Medical College
representing consulting fees for the period ending April 30. If my
calculations are correct, we are now "current" with the payments from

the Association.

I am obligated to leave a 'clean' grants situation at
in September. As I mentioned, I am able to support some of the
studies in the biochemistry of CSF in ECT in relation to the balance
available to me in the ECT grant. Unhappily, these funds are limited
and I can sustain the relationship until the fall. With regard to
Mrs. Heldman, as we have no reasonable support in the offing, I will
ask that she be transferred tp other funds available to you, effective

NYMC

August 31.

I have discussed this with Dick, and ehile he is willing
to continue collection of samples and freezing them, he will discuss
with you the most feasible ways of continuing his work.
My

holidays during July will be spent in the Adirondacks,

My

best regards.

and I can be reached through my office. I will return about August 1
and we can discuss the future work and the data of the present studies
at your leisure. Also, should it be possible, I would appreciate
your reaching Rhea to see what can be made of the cannabis data.

Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>"liq“.- .

“ﬂﬁﬁm
‘,"',.'I

.J
m

E

-‘

Hit

533%?“

1‘

Jun. 16.

“sm-

3-way?

1972

l1"?

"

E

-

Lr.;n"_¥§t.

J»

E
7&gt;'
"v

j

"‘1:."“I"“"~iﬂm.

'.

Hr. Robcrt Cuddihy

2‘:

Drug Information Bulletin
Sandoz Pharmaceuticals
Hanovor, New Jersey 07936

:Lr

':&amp;‘LmiL-fzi..L-’;JZ
,“,.-~.‘

A

Dear Mr. Cuddihy:

Enclosed at: two copies of the report ”Quantitative EEG
as a ﬁensure of €88 Bioavailability of Paychoactivo Drugs", which
was presented to the DIA in May, and which is submitted for your

considoratton for the

Drug

Information Bulletin.

Sincerely youro.
ﬂax Fink, H.D.

Professor of Psychiatry

KF:13
Enc.

fur-‘1’,

�</text>
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                    <text>June 16, 1972

Exacuttvu Sacrutarial

International Symposium
Clinical Pharmacology

Pontiach

on

345

3-84 Eagensburg

West Germany 1
Guntlamen;

I obtain the noceanary rugistratiou information and
preliminary prograus for the moctings scheduled August 10«13. I
have submitted an abstract to Professor E. Garrett.
Hay

Thank you.

Sincerely yours,
Fink. ﬁ.ﬂ.
Professor of Psychiatry

Hex
MF:1g

�</text>
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                    <text>June 16. 1972

Profossor Edward Garrett
University of Florida
Gaineavillo, Florida 32601
Dear Professor

Garrett:

In March, I submitted an abstract for your consideration
for tho Intornntional Symposium on Clinical Pharmacology 1n Regen8~
burg. I havo received no further information, and am writing to
inquire what programming decisions hovo been made.
Romy

thanks.
Sincerely yours,
Ha: Fink. M.D.

Prof-330: of Paychtatry

ﬂf:1g

�</text>
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                    <text>June 15, 1972

Mr. John Mcﬂiff
334 ﬂowery

Apt. 7F

New

York,

New

York 10012

Dear John;

I regret your decision to leave, for I do believe that you
contributed to the success of the program. but, as Bob and Bruce
are finding their way in other educational programs, I am sure you
will do well in yours.
Good
many

years.

luck in your studies, and
‘

Yours

Max

my

thanks for your help these

truly,

Fink,

M.D.

Professor of Psychiatry

HF : 1g

P.S.

We

will send your check, including earned vacation to the

address given.

�</text>
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,.

.«w—v'7' —u w'—"uw

A

n.

7*“ may

June 15. 1972

John m. Davis, M.D.
Department of Psychiatry

Vanderbilt University
School of {wiediclne

Rashville, Tennessee

37232

Dear John:

I have read your letter, "Chotinekgic Revenbaz 06 Manic
Symptomo" in the Lancet of June 3 with much interest. The role
of cholinorgic mechanisms in depressive states ané their treatment
has been ignored for too long, and such data as you present is most
role of cholinergic mechhelpful. Some years ago, we reviewed the
we were intrigued by
ECT.
of
by
depression
anions in the relief
diethazinc,
benactyzine,
of
cnticholinorgics
(g;g.,
the ability
such
physiological
ECT
(and
induced
improvement
Ditran) to reverse
I am
EEG)
states.
and
depressive
the
to
exaggerate
indicer as
thooc
otudiea,
summarizing
of
a
reprint
enclosing
the
taking
liberty
own.
complcmentary
to your
as
But I am writing because I am particularly interested in
your comment, "... that norihuann*induccd euphoria and talkativencss can be converted to a severe depressive syndrome by phyoostig~
mine". I do not recall these data at the APPA meeting. and I am
to
writing to ask if a copy of that report can be made availablewith
interactions
by
of
effects
of
The
method
drug
analysis
us.
known pharmacologic agents is one that we have just begun to apply
to our studies of cannabis.
ﬂany thankn.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

ﬁfzig
Enc.

�</text>
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                    <text>June 13, 1972

Mr. Gary Boyer

Biomedical Section
Cancer for Studies of narcotic
and Drug Abun-

ﬂotional Institute of Mental Heolth
5600 Fiohoro Lona

Rockvillo, Maryland

Dear ﬁr. Boyer:
A~9, and

Our ongoing

v.3.

~ NINE

studios of cannabis ~ comparing hashiah THC~
marijuana in Greek chronic bookish unors re—

quires additional supplies of marijuana (35 grams. 2.6x

THC~A-9)

and IEC~A~9.

Pilot studies on these subjects for other constitunnts or:
in progress, ond so request additional amount: of THC—A—s, CBN, and
GED.

The appropriate Bab—2226

my

is enclonsd.

thanks .

Stncoruly yours,
Max

Pink,

211.1).

Prof-user of Psychiatry

Mrzig

Sac.

�</text>
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                    <text>r7.

.

,

~.,.'.._._.~mmwvm-v '3'".

WWﬂW—v—m

-

-

-:2-

~—

,

w'mr‘wnwn‘n

unwahilmw'rwnw‘m‘m‘r '7'“, w": .m

Wynn“.

June 12, 1972

—

r”

w—,

"cw-nun

m,-

F. Gilbert McMahon,M.D.

Department of Medicine
Tulane University School of Medicine
New

Orleans, La.

Dear Professor McMahon,
Thank you for the invitation to participate in the
symposium, Clinical-Pharmacological methods of Drug Evaluation, to
be held in New Orleans next March. I will be pleased to participate
and to discuss the role of EEG methods in new drug evaluation and as

indicies of bioavailability.

In your outline, you indicate the other titles to be
reviewed in the session. If it is of any help, I would suggest you
consider Milton Kletzkin, Ph.D. of Wallace Laboratories, Cranbury,
New Jersey for the review of skeletal muscle relaxants. If he is
unable to carry out the assignment, I am confident he will be able
to recommend someone to you.

Similarly, Dixon Woodbury is well known for his interest
in the anticonvulsants; or, possibly you would wish to consider one
of the more classical neurologist-clinicians as Gilbert Glaser or

Melvin Yahr.

fall,

may

As I will be changing my university affiliation this
I suggest that my address of record he changed to:

P.0.

Box 269

Great Neck,

Communications addressed to

Again,

my

that

New York 11022
box should reach me promptly.

thanks for the

invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Juno 3, 1972

T0:

Billie Jones,

FRDH:

Max

SUBJECT:

Freeing of ﬁrs.

M.D.

Clhnical Director
Fink. H.D.

Thomas From 15A

On my return from a trip I find
Mrs. Thomas from 15A to another service

that you have tranaforred
at ﬁetropolitan ﬂoaﬁital

at a higher salary. effective immediately.
I

am

pleased that you think so well of

staff to seek her services, for I

know she

a member of

the

ISA

is capable. I even ooro

dolightoé that you ovaluato her sarvicaa as worth about $5,000 more
we are paying her.
I have indicated to Mr. Schwartz, on prior
occasions. that the staff ware grossly undorpaid, and your evaluation
than

confirms

this judgmont.

While I am grateful for your confidanco, I am aware that
Mrs. Thomas is directly roaponaiblo for patient care. until we
have an adequate roplacaonnt. I have asked her to continue to oervo
15A. I know that you will agroa that bar promotion in work duties
ahould wait upon a roplacanant, for otherwise tho patients will
suffer a loss of care; but that Mrs. Thomas does not suffer for her
unuaual capacity and rocogniaing your judslant, I am asking ﬁr.
stowartz to pay her new salary ottoctivc innodiatoly.

Again, I thank you for your confidant. in our

cc: 1.

B. Schwartz
Mr. M. Thomas

or.

x. Koanick

Dr. R. Levine

staff.

�</text>
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                    <text>w."

WWM',

June 7, 1972
Mr. John A. Hamilton
New
New

York Times
York City

Dear Mr. Hamilton,

1

I very much appreciated your balanced presentation of
the problems inherent in a heroin delivery research project in your
article, Free Fix fbr Addicts ? on June 5. In addition to the problems
described by Drs. Jaffe, Dole, and Phillipson, we should add the special
risks of heroin administration. In our studies at this center, we have
used 'heroin challenges' as a specific index of the duration of action
of narcotic antagonists. This experience has brought to our attention
that intravenous heroin has effects on heart rate and the EKG; on
cerebral rhythms (exciting seizure activity sufficient on at least three
occasions to precipitate a grand mal convulsion); and on respiration.
The sequence of events are often unpredictable, since the men vary in the
degree of the induced cross-tolerance to opiates they have developed.
Even in the laboratory, there are problems; we are not sanguine about
a large scale delivery system.
Indeed, rather than seeking the use of shorter acting
opiates, as heroin or morphine, there is logic in seeking opiateelike

with durations of activity longer than methadone. Levomethadyl,
the l-alpha-acetylmethadol, is such a substance. Instead of seeking the
use of a short acting substance, the leaders desiring to innovate might
do well to look into the greater use of this substance: by providing a
longer duration of cross~tolerance, dosages must be taken only three times
a week, reducing both the problems of irregular intake and that of
'seepage' of illicit materials into the community. Levomethadyl is
also taken orally, as is methadone.
compounds

Again, I wish to commend you
heroin delivery recommendations.

on a reasoned view

of the

Sincerely yours,
Fink, M.D.
Professor of psychiatry

Max

�</text>
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                    <text>Jun. 7,

Jean Paul Smith and Alisa Runs

To:

1972

,

national Institute of Hental gtzicn

5600 Fishers Lane
Rockvilla, Maryland 20852
ﬂax Fink, ﬁ.D.

PROM;

SUBJEDv4

4

Drug Use:

harcotic Addiction

Program

During 1972-73, the SUNY~Stony Broot Drug Abusa ptogram.will

examine tha usefulness of cyclazocinc in their treatment of opiate
to methadone and leVumethadyl. In this
dependence, and compare
study. diacetylmorphine will be used in “heroin h lleuges” to mea—
sure tha degrea-of blockade (to éefine adequacy, duration) and to
demonstrate the potency of these substances as a 3tep in the decon*

it

.

ditianing process.

(1) nglggggigg. After detoxification, patianta will be
1ndt¢tod to h—6 mg. cyclazocine in 4~6 days. As an antagonist to
the agent-tic features of cyclaxocine, naloxone hydrochloride (0:31)
600 mg. q3h; prr.n. will be availabln for the 4»6 days of the in—

duction period.

�Jean Paul Smith

8

Allan

2

June 7, 1972

Romany

Following the ptovailing high dose roginono,
on will induct patients in 20—40 days to 100 mg. oral daily. (Should
it peeve hooful, we may adfpt a low dose (50 mg/dly] schedule).
(2)

Mothodono.

0

Induction to 80 n3. thrac
in plannod.vith tho induction poriod of 6 weeks.
(3)

v. will

Levomothadz .

tin“

a week

(b) Heroin Chgllongo . Following our doocribod nethoda,
use intravonouo heroin (20,30 ng/lcc onlino/luiinutc) when

subjects at. drug-fro. (to dotino heroin response) and whom induction
to cyclnxocinc, levooethadyl, or nothodoln 13 achiavod, to define
efficacy and duration of blockade, and b» {novide a basis for do—
conditioning.

mueaﬁﬁeﬁem
Based on 50 patients receiving cyclazociné, and 45 each on
methadone and levomethadyl.

6: 90

liters,

Cyclazocine:

36

Naloxonoﬁ

240 grams (800

Methadone:

500 grams (powder)

Levomethadyl:

150 grams (powder)

Heroin;

10

grams

grams

tablets,

(powder)

2 mg/Scc)
300 mg each)

/

�Joan Paul Smith

&amp;

3 _

Allen Ramsay

Juno 7. 1972

CITAIIOHS

Haloxonn Paloata: A Long~Act1n3 Opiate Antlgoniut, (submitted for
publication). (R. Lavina, A. 23kt. I, A. Frudlun).

Luvoanthadyl 1n Haintenanco Trcatncut of Opiatc Dopendcnna.
(A. Zaka, f, A. Froodnnn).
Duration of Hathadon. Induced Crocc~Toleranca to attain.
Addict. 66: zoswzos. (A. 2m, 9. A. M. Kama-nu).

84.

J.A.%.A.,

'“

I

J.

Cyclaxocina Therapy of Opiate Uepcndcnca w &amp; Progress Report.
Compachenb. Psych£a£., 12: 491‘502, (R. Rasnick, 3, and A. M. Freedman).
A

Rational Therapy of Opiate Dependence:

Amen.
and R.

J.

NuAéLug, 71:

Maniac) .

1359-1363.

Harcotic Antagonists.

(with A. H. Frocdmsn, A. inks,

Naloxone Traatment of Opiate Dependence.
(A. Zaks, T. Jonas, A. ﬂ. Fraedmnn) 5).

J.A.M.A., 215:

2108*2110.

Cyclarocins Typology in Opiate Dependence. Amen. J. 7&amp;ychiat.,
1256-1260. (B. ﬁesnick, # and A. H. Freedman).

126:

Intravenous Qiacetylmorphina (Heroin) in Studies of Opiate Dependauco.
Ned». Syét. Supp£., 33: 89~92, 1969. (A. Zaka, A. Brunet, 5.

die.

A. Freedman).

aaloxone in heroin Depcndence, C££n. Phanm. Thenap., 9: 568~577.
(with A. Zaks, R. Sharoff, A. Mora, A. Brunet, S. Levi: and A. H.
Freedman).

Clintcal Studies of Cyclazocine in Narcot1c Addiction. AmeA. J.
P3gchiat., 124: 1499~1504. (A. a. Frcedman, #. ﬁ. Sharoff, and
A. Zikl).

V/

�</text>
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                    <text>May

17, 1972

Mr. R. Graﬁwcll

Contracting

folcct

Jotional Institute of

Manual Hoalth
20852
Rockville, Maryland

Dear Mr. Graduall:

Enclosed

is a formal application for the study:

PHYSIOLOGICAL EFFECTS OF CﬂRﬂHIC CANNABIS
USE IN HALE JAHAICANS

The protocol and budgets have been worked out in detail
with Professor Michael Booubrun of Jamaica and the staff of the
HIHE, Division of Narcotics and Drug Abuse.
We

look forward to meeting with you noxt week.

Sincoroly yours,
Fink, H.D.
Profcsoor of Boychiotry

Max

Hing
Enc.

�</text>
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                    <text>ﬂay 15, 1972

Representative Paul Rogers
Representative:

House of

Washington, D.C.
your Sir:
Some

months ago you were kind enough to discuss the national
and invited any progress report-

effort in the narcotic antagonists;

be brought to your attcntion.

Enclosed are some report: I have pulled togathcr in
to the extensive publicity given the Vera Institute proposal response
by the
New York Times, radio and TV mndia.

Sincerely yours,
Max Fink. ﬁ.D.
Professor of Psychiatry

MF:1g

Enc.

�</text>
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                    <text>.vrrw- paw.»-

-.. .

x.

.

~

"w...“

v-

-

w

m’m-rr‘aa’ll¢\mn—w'ru'

".

Arr..»-.—...; .... m

.mwrnv ”.1“.

'I-W

a..- mu—u—rugnwmq...

._

.N .

”we“. , w.“

.

,

..

e

.. w...—

rhuwwnw «we... st

5"”!

May

a“

12, 1972

Robert L. Robinson, Editor

Psychiatric News
1700 18 Street NW

Washington, D.C.
Dear Robbie,

I am pleased to enclose a copy of the special issue of
Seminars in Psychiatry devoted to the newest experiences and theories
about ECT and Indoklon therapy. This issue serves the special purpose
of bringing up-to—date the clinical experiences with unilateral ECT,
multiple ECT, Indoklon Edi; some of the theoretical formulations assisting research to understand this process; and some interesting questions
and answers most frequently asked by students about this unusual form
of therapy.

Perhaps, you would think
reviewed for your readers.
Many

it is

done well enough to be

thanks.
Sincerely yours,

man-um

.
"no“

:
ngn

nwrur-

wm-zvvu

nravmsr-

V’THVV‘I

,,.
m-x

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>May

ll,

1972

Miss Candy Poinior
Colby College

Wotarvillo, Raine
Dear Min:

It

Poinior:

like I will be unable to visit Colby College
this
I am willing to offer you an opportunity to work
in this laboratory as soon a: school is over:
now

looks

month, and so

In

New

York

until

September/October.
a Research

we nova

to Stony Brook in

Technician at $7,200/yoor
in training. plus the usual perquisites of
fringe benefits (Blue Cross. insurance. holidays.
sick leave, etc.) of the College now (and the
comparable at SUNY—Stony Brook in the fall).
As

return .

Enclosed

is

on

(EEG)

application form; comploto what

you can and

I look forward to mooting you.
Sincerely yours.
N.“ Pink, PhD.

Profoloor of Psychiatry

HPxig
ﬁne.

�</text>
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                    <text>May

Mr.
9

Patrick

11, 1972

Slbonoy

Winter Street

Hatorvillo,

Maine

Door Hr. Sibonoy:

It now looks Ilka I will be unable to visit Colby Collage
this month, and so I am‘villing to offer you an Opportunity to work
in this laboratory as soon as school is over:
In ﬂew York until we move to Stony Brook in
September/October.
a Ronaarch (EEG) Technician at $7,200/year
in training, plus the usual perquisites of
fringe benefits (Blue Cross, insurance, holidays,
sick loave, etc.) of the College now (and the

As

comparable

return.

Enclosed

is

an

at

SUNY-Stony Brook 1n

the

fall).

application form; conploto what

you can and

I look forward to looting you.
Sincoroly yours,

“a
m. ”In.
Protoooor
of

Psychiatry

ﬁrsts
Eat.

�</text>
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                    <text>Hay 11, 19 72

Representative Paul Rogers
house of Iepreaenrativos

Nashington, D.C.
Dear

Sir:

to discuos the national
invited
any progress reports
effort in the narcotic antagonists;
attention.
(and problems) he brought to your
Enclosed is some material I have pulled together in response
Now
York Times publicity and apparent enthusiasm for heroin
to the
50m: months ago you were kind enough

and

maintenance.

the lites indicate, there may be a small problem in the
supplies of dipronorphine. ‘We have been assured of assistance byShould
saooAP; of intereot by Lederlo; but the facts are at variance.
you wish to assist those researchos, an inquiry from your office may
be productivo.
As

Sincerely yours,
Fink, M.D.
Professor of Faychiatry

Max

ﬁfzig
Enc.

�</text>
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                    <text>May

10, 1972

Dr. David de Wied, ﬂ.D.

University of Utrecht

Vondelann 6

Utrecht, Netherlands
Dear Dr. do ﬂied,

June.

My

I look forward to your visit to
present plans for that period allow
We

New York
me to be

at the
in

New

end of
York.

are presently in a study of 01-63 and the data collection
It will be most interesting to discuss

should be well along by then.
the work and the background.

Please write to

Irrive in the city
in the evening, at

me

for a specific date. Should you
at 212—369 8488; or

you may reach me in New York
my home, 516 466 5444.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                  <elementText elementTextId="106454">
                    <text>May

10. 1972

Editor

Science

1515 ﬁaaaachusetts Avenue, R.W.
dashington, D.C. 20005
Dear

Sir:
We

Long~Aoting

are pleased to submit the report ”Saloxone Pamoato:
npiato Antagonist" for your consideration.

A

your columns have noted, narcotic antagonists represent
a logical applied approach to both the treatment and the prevention
of opiata dependence. while naloxone pamoate does not satisfy our
clinical needs, the extension of duration of action with safety ﬁenonstrates the feasibility of such approaches.
As

aefereea for this study
Jonathan 0. Cole,

may

M.D.

include:

Boston State ﬂospital
Boston. Massachusetts 02124

Jerome K.
SADBAP

Jaffe,

M.D.

Hhite House
Washington. D.C.
William R. ﬁartin. 3.9.
Reaearch Facility

HIRE

Lexington, Kcntucky

�Editor

ﬂay 10, 1972

Irwin J. Pachter, 3.».
Bristol Laboratories

Syracuse.

ﬂew

York 13201

Robert H. Rees. H.D.

Sterling Winthrop Laboratories
90 Park Arman:
sou York City 10016
Thank you

for your consideration.
Sincerely yours,
ﬂax Fink, H.D.

Profeasor of Psychiatry

leig

Enc.

�</text>
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                  <elementText elementTextId="103645">
                    <text>r

ma—

7

x

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.m. ”rely a,

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a-“
t

V.

v

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,

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8, 1972

Editor,

Arzneimittel-Forschung
Aulendorf, west Germany
Dear

Sir:

Clinical
We are pleased to submit our study,
Evaluation af’GPh41299, for your consideration. This study focussed
on more general clinical studies of GP-h1299, a compound under inten»
sive clinical study in Europe as a soporific.

first

became interested in GP-41299 when an EEG
to have s profile similar to doxepin
profile analysis showed
(Sinequan). Based on this analysis, we anticipated clinical antianxicty and antidepressant activity.
We

it

This report describes an assessment of its sntianxiety
potentiality. As we believe GP-41299 has aroused more interest in
Europe than in the United States, we are pleased to submit this report
for your consideration.

Sincerely yours,
V

,

Fink, M.D.
Professor of PSychiatry

Max

..

.70”,

.{

“Hr"-..

mummy».

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�</text>
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                    <text>say a,

1972

Re:

13358-06

Jerome Levine, M.D.

Psychopharmacology Research Branch

Eational Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852

NH

Dear Dr. Levine,
.vw._..p

tW‘f—‘r‘v-

,
.

wvtr—UU)Y.".RJ

I have been invited to join the faculty of the State
University at Stony Brook, and I am writing to request transfer of the
program, EEG and Human Psychopharmacology, HE 13353—06, and the
equipment purchased under that program, on October 1, 1972 to a new

institution.

This transfer has the approval of the Chairman of the
Deg:rtment of Psychiatry of the New York Hedical College.
r."

'N.’:,

n

m

.1

list

of the equipment to he transferred is attached.
the
part, this equipment was purchased with funds of grants from
MB
18172
and
under
Abuse,
Drug
Division of Narcotic Addiction
project
(Dr. Robert Petersen, Project officer). This project terminated April
30, 1972. Insofar as this study may continue, and in support of the
study, Opiate Effects on Brain Function and Behavior, ME 19476 which
will remain at the New York Medical College, we will continue to carry
out the data analyses at the new facility. With this assurance, Dr.
Petersen has indicated that he will agree to the transfer of the
In

A

equipment.

w

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have arranged for my continued participation in the
programs of the Department of Psychiatry of the New York Medical
College for a minimum period of one year to allow an orderly transition.
This will allow for the transfer of responsibilities of those employees,
now working on NH 13358, to other ongoing programs.
We

have received an estimate of $16,250 for preparation of
the site at the State University at Stony Brook tp carry out both the
recording and analytic parts of this program. The space assigned by

I

the University is adequate to the needs of the program. In developing
a budget for the period beginning October 1, 1972, I shall request
permission to transfer this amount from the existing categories to
that of "renovation"; and an additional amount for 'moving of equipment".

�As

evidence of the agreement of the College to this

transfer, I have asked both

Dr. Freedman and the appropriate

the College to sign this request.
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I would appreciate your guidance
should take to make this transfer orderly and
with the studies. My thanks, once again, for
your associates have given this program these

assistance in this transfer.

officer of

as to the next steps we
with minimal interference

the support which you and

many

years,

and

for your

v—"Y'

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Sincerely yours,
imam"...

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Max

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Alfred M. Freedman, M.D.
Professor &amp; Chairman

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n.

Lorraine Lasker

Director, Research Administration

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Fink, M.D.

Professor of Psychiatry

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Equipment Purchased by New York Medical College under the following
grant programs: ME 13358, 18172; and College funds 46-122-1

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Items to be transferred:
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wt.

.

IBM

4-

including 1801, 1442, 1443, 1810, 1851, 1856;
book
card files;
cases; table; disk storage and supplementary
disks; tape storage and tapes; analog tapes (excluding
those to be used by Dr. Volavka)

1800 computer complex,

Hewlett Packard oscillators
1/2" tape recorder
Krohnheit filter
EEG polygraph
Ampex

£~P'P‘H'P‘k‘hJ

EEG

coucy

Tektronix oscilloscoPe
armless chairs
executive desk

secretarial desk
chairs

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drawer files
bookcases
5

sets shelving
large cabinets

selectric typewriter
Friden calculator
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projector

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Equipment purchased by IAPR now

V

Grass polygraph

oscilloscope

oscillator

P‘h‘h‘h‘h‘h‘h‘h‘

Kronheit
HP

filter

tape recorder
tape recorder

Ampex

couch

side table
desks

chairs

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file cabinets

sets shelving

coay stand

«yum

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.'
.

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at

5

East

102

Street, to

be

transferred:

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--

Equipment purchased under
Remaining at NYMC:

grants, Psychopharmacology Funds,

and IAPR

At Metropolitan Hospital:

All laboratory and office equipment on 15a and 15b including
laboratory on 15a; office furniture 15a, 15b, Psychopharmacology
Clinic; typewriter, dictating machine, tape recorder for EEG and 2
tape recorders for voice; a air conditioners (window units); and
complete clinical laboratory equipment and supplies.
complete

EEG

EEG 4

At

5

channel, oximeter, typewriter: These units are
in use for ECT studies and
will remain. Should these
studies terminate, EEG
may be transferred to other
studies or returned to IAPR.

East 102 Street:

list:

6 offices including
typewriters; l calculator; 2x2
slide projector and screen; refrigerator; safe; storage cabinets;
keypunch; and sufficient analog tapes for work at Metropolitan

See attached

desks, chairs,

Hospital.

files,

bookcases;

remaining are
2

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                    <text>Hey

5,

1972

Dr. Alfred Ling

Cibs Pheroeoeuticels
Division of Cibe Geigy
Summit, Rev Jersey 07901
ii

mf'w

Dear

ﬁr. Ling:

Separately, I on sending you e complete file of the dots
for our study of 69—41299 vs. placebo in outpatient anxious neurotic petionte. The study in an outgrowth of
our EEG studies, which indiceted thet GP £1299 exhibited profiles
and data analyses

similar to

domepin.

This study assessed the "anti~anxiety” component of the
drug. we were unable to examine the entidepreessnt features, but
look forwsrd to reports by others who any here been encoursged to

assess this feature.

are submitting the summery for publication to Arzneimittelforochung. The study was monitored by Edgar Grunwnldt and Vilma
Harrison. and I have sent them copies of the summery report.
We

Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
HF:ig

cc: E. Grunueldt
w. Harrison

�</text>
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                    <text>May

4, 1972

Dr. Bertram S. Brown

Director
National Institute of Mental Health

17-91
Parklawn Building
Room

5600 Fishers Lane
Rockville, Maryland

20852

Dear Bert:

In line with the announcement in the APA Monitor, I am
pleased to commend Rhea Dornbush, Ph.D. for your consideration
for membership in the NIMH advisory boards or study sections.
She is an able experimental psychologist, recently recommended
by Al Freedman and myself for promotion to Associate Professor.
She has made important contributions to studies of memory
function in convulsive therapy and with marijuana; and to the
psychological effects of cannabis. For the past year she has been
the principal scientist in the overseas study program of chronic
hashish users in Greece, and is organizing a study of ganja users

in Jamaica.

will

Her curriculum

commend
My

vitae is attached.

her performance.

I

am

sure

A1

Freedman

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ig

an.

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                    <text>\‘

'3’

_

V

May

Jonathan 0. Cole,

a,

1972

M.D.

Superintendent

The Commonwealth of Massachusetts

Department of Mental Health
Boston State Hospital
Boston , R‘Iassachusetts 02124
Dear Jon:

I have asked Michael Taylor about the use of an antiandrogen in patients with abnormal sex drive. You may consider
cyproterone acetate (Schering, Ltd.) a compound introduced
—

by German

workers. The most recent report by Cooper gt_§l.,

appears in dnit. J. Pbychiat.,

on your

It

may

be worth the

next trip East.

120:

59, 1972.

effort to import

some from England

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming

�</text>
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                    <text>vw—

1-

cry-- .7...

.

n. 7-; Imernmv 'w

..

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agmwm.” Va“. -n\—“T'r’rurvr-W

«-

’1'

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~P-

_

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any." ”"1“,”

'v

-.

April 30,
G. James

,4

-. ”.7

3...-

.m.

,, 77.-.-

’7

1972

Gallagher

Williams a Wilkins Co.

Baltimore, Maryland

Dear Mr. Gallagher,

I have receiver your announcement that you intend to
reprint my contributions to the Comprehensive Textbook of Psychiatry
in a synoptic version.
were written

applications

little merit. Both contributions
have
and
been many changes in computer
there
in 1966,
to medicine and to psychiatry in particular; and the

That suggestion has

treatment of schizophrenia is considerably altered.

that these not be reprinted at this
time, unless the title indicate that these were the opinions of the
author(s) half a decade ago.
I

would ask

Good

luck in your projects.

(0n re~reading the letter, you indicate that the articles
will be 'adapted‘ and 'updated'. Surely. if this is done by someone
else, my authorship will not be referred to, except as the usual
citation and reference, similar to any other source in the public

domain.)

Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

,

3n

:m

v

w

a

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                    <text>28
G.

April

1972

F. Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Gary,

Thank you

for your letter of April

7.

have entered into a contract with Woodard Laboratories.
their work with the 10 grams diprenorphine you sent me,
and earlier this week called to say that the material is sufficiently
non~toxic that, to meet the FDA requirements, they may require an
additional 15 grams for toxicity studies.
We

They have begun

I called Dr. John King, as your letter indicated (I had
not heard from Dr. Kiltie or Dr. King) and when I broached the subject,
he said that he would call me back that day with some answer. He
did not call back.
Since the White House has entered into negotiations with
Lederle and with yourselves, it is clear that our original understanding
(that of supplies from Hull) is no longer valid.

I have indicated to Dr. Jerome Jaffe that, in the face of
office he holds, I can do no more than wait patiently for
some resolution. The present studies will end within the next fortnight,
lacking additional supplies.
C'est la vie !
the

awesome

my

best regards.
Sincerely yours,
Max

Fink, M.B.

Professor of Psychiatry

�</text>
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                    <text>v
x
«w».

vars"

“w":

1'.”

a...

w

.

m,

,p-”

Y.

«N.

3.

“My.“

xiv”..wmc,w_w,,m,

WNW"

"VI-r

2..

“rs-m”...

,

.-»-,.v_

wavwa.

'x-

,

..

&lt;

.r-m..,

,

. v-v-‘r'ua

......—.«..,.w._»—wn-r-mvmum-t..--/)"'-v-\ -~

Mailing Address:

PO

Box 269

Great Neck,
New

April 27,
Dr.

J.

M.

Dille,

York 11022

1972

M.D.

Department of Pharmacology
University of Washington

Seattle,

Washington

Dear Dr.

Dille,

98105

Thank you

for the invitation to participate in the

symposium on anorexigenic agents on May 19 at the Americana Hotel
in New York. I look forward to the session, and thank you for
inviting my wife as well. She will not be able to attend, but I will
appreciate reservations at the hotel-will save my commuting for

it

the sessions.

An

abstract of

my

presentation is attached.

I graduated the New York university College of Medicine
in 1945; went through the usual residency training programs to become
certified in neurology (1952), psychiatry (1954) and psychoanalysis
(1953). I have had numerous positions includingDirector, Missouri
Institute of Psychiatry and Research Professor, Washington University
School of Medicine (St. Louis), 1962-66; Professor of Psychiatry and
Director, Division of Biological Psychiatry, New York ledical College,
l966~ . My principal interests are in quantitative EEG and clinical
psychopharmacology; computer applications to psychiatry; ECT and
other biological therapies; and recently, narcotic abuse with special
emphasis on narcotic antagonists and cannabis.

I look forward to meeting
participating in the panel.

you

in

New

York, and

in

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

ww—

�I

April 27,
Panel Discussion:
_,

Max

Fink,

M.D.

1972

Should the Physician Retain the Option of the
of Anorexigenic Agents ?

Use

New

York Medical College

.w-’

~__

.7..

.

,,

Much

A”

specific aspects

therapy results from the interaction of drug
and such

non-specific factors as doctor-patient

,,..-,.wm__,v__.,,wﬂ..4..n..ﬂ..

MW...

attitudes, expectations of both,

and the experience of the physician

with the available therapies.
Anorexic agents

.

r,

are not

initially

differ in secondary effects,

some

obvious: amphetamine and methanphetsmine

stimulation, insomnia,

and

irritability;

of which

elicits

while fenfluramine excites

a sedative response. Both agents should be available to the physician
whi must decide on the

best therapy for his patient.

Limiting the physicians therapy with anorexic agents

is but

one instance of

limitations that fail to serve patients: in other

fields, other applications could also be interdicted that have been
found

useful.

The

narcotic antagonist, cyclazocine

was found

to be

a successful antidepressant; imipramine was found to be snantidepressant;
high dose fluphenazine was found to be antipsychotic-- these are a few
examples of

useful applications that could have been restricted

by

inexperienced committees.
Physicians should be allowed to give any of the available

therapies, using published guidelines as suggestions, but not as restrictions;
but this freedom should carry with

it

a willingness to accept a responsibility

for his actions, including unheralded side-effects

and

their consequences.

�</text>
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                    <text>v.-.~

r.-.

.—

-.W......_-_

r-&lt;~

A

Vanna—w

’4)

April 27,

1972

Dear Turan,

KBknel's observations of a definte relationship between
marijuana use and hard drug use should be reported, if the data is indeed
good. To my knowledge, there is no satisfactory of any causal relation
between the use of these drugs; they are often combined by propinquity.
The issue of causal relationship has been reviewed by the Commission
on Marijuana in its recent report (1972) and by the two reports
of the Surgeon General to the Congress on marijuana use—— 1971 and 1972.
ypuucan imagine, defining a causal relationship is
and I doubt that KBknel's data is much better than that
,presented before. Should you be convinced of its merit,
is eminently
publishable. Perhaps, you would write to Leo Hollister who is
organizing a marijuana session at the CINP and he may give KBknil
most

As

difficult,

it

some time.

Don came

back from his

visit all

enthused with the fine

data you are getting in Copenhagen and in St. Louis.

work

!

My

best regards to Ellen.
Max

Keep up

the good

�</text>
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                    <text>April 26,

1972

Mark F. Lewis, Ph.D.

Chief. Visual Proceeeee Unit
Aviation Psychology Laboratory,

Civil Aeromedicel Institute

P.O. Box 25082
Oklahoma

AC~118

Oklahoma 73125

City,

Dear Dr. Lewis:

Enclosed is e registration form for Iyeelf and one of my
cadworkers, Dr. Rhee Dornbush. I have aeked Dr. Dornbush to attend
the meeting and we have separately requested a reservation at the
Sheraton Inn on her behalf.
have reviewed the work we would like to present at the
I would ask that you amend the authors to include:
Max Fink, M.D.. Rhee Dornbueh, Ph.ﬂ.. Jen Volevke, K.D., and Alfred
Preednen. M.D.
we

Sympooium and

The

preeentation title should be

amended

to read:

"Acute and Chronic Physiological and Behavioral Effects

of

will

THC

and Herijuane

in Volunteere"

We will propere e manueoript for publication, which hopefully
be reedy at the time of the meeting.
My

secretary has

to Oklahoma City on
15, Flight #664.
Again,

my

TWA.

reservations from LeGuerdie Airport
Flight #73 on June 13, end returning on June

made

thanks for your

invitation.
Sincerely yours.

,,

Max

wlr't"

Fink, M.D.

Professor of Psychiatry

MF:ig

Eat.

�</text>
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                    <text>April 26,

19 72

ﬁr. Frank J. Liska
ﬁanager
Corporate Data

&amp;

6.

Information Services

D. Searle &amp; Company
IND. Box 5110

Chicago,

Illinois

60680

r

Dear Hr. Liska:
Thank you

Statler Hilton.

for the invitation to breakfast on Hay 18, at tbs
I look forward to meeting you at that tins.
Sincerely yours.
ﬂax Fink, E.D.

Professor of Psychiatry

�</text>
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                    <text>April 26.

1972

Dr. D. Ladewig

Psychiatriacha Universltatskliaik

£056 Basel/Schweiz
Wilhelmvxleln—Strasso 27

Basel, Switzerland
Daar Ladewlg:

I will be pleased to see you in ﬂow York on May 10. Please
office on May 9, (121—369~8488). 0n ﬁay 9, unfortunately;
call
be
out of town but I shall he in all of May 10.
I will
my

New

I will be pleased to-haﬁo you

York Modical College, 8 Floor.

will participate in our discussions.

Ry

visit

our laboratories at

cowworkor, Dr. Dan Volavka,

Sincerely yours,
Hat Fink,'ﬁ.D.

Professor of Psychiatry
Mfzig

�</text>
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_,-/__

“

.~.

.

-

mm..—

2“,»;

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v'}.

vs.-

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mv

April 24,

Fritz Freyhan,

1972

M.D.

St. Vincent's HOBpital
New York City
Dear

Fritz,

Since I received your invitation to edit a volume on
drug abuse, I have made many efforts to put the issue together. Many
of the men who ordinarily would be capable of contributing complain
that they are over-committed with their working assignments, or
have already contributed chapters to other volumes.
My

suggestion that the program of the

ACNP

be the

focus of the volume seemed an acceptable solution. But as I

started

to plan that session, I find that my committments to EEG, ECT, and
my move to Stony Brook occupy so much of my time that I cannot
undertake that responsibility at this time.

Fisher explains my dilemma. I still
program, ﬁnder another chairman can form a fine
volume for your series; and I hope that this may be useful to you.
Meanwhile, please excuse me. The tide of the times is such that I
must expend my energies in less politicized and more regarding
fields of study.
My

believe that the

My

letter to
ACNP

Sy

thanks for your consideration.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>April
Fred Clark, M. D.
Robins Cb.
1407 Cummings Drive

I], 1972

A. H.

ﬁichmondL

Virginia

Be; Labelling

of

Butaperasine (Repoise)

Dear Fred,

I am pleased to answer the inquiry regarding the labelling
of.Repoise (butaperasine), limiting its application to patients with
chronic mental disorders.

I have

studied butaperasine since

1964,

assessing the

clinical effects in chronic schizophrenic patients; the EEC and clinical
relations; the effects of'concentrate (syrup) Repcise in acute mentally
and in association with Dre. Itil and Holden at the Missouri
ill;
Institute of‘Psychiatry, have been acquainted with their data on the
effects on clinical laboratory tests and the EKG.
In these studies, and in reading the published data, we
to be an effective antipsychotic agent with a
low profile of'extrapyramidal effects. Dosages can be increased rapidly
and the therapeutic effect can often be observed in 3 to 4 days. In its
EEC profile, putaperasine exhibits a characteristic hypersynchrony of
alpha activity, enhanced amplitudes, decreased variability of'frequencies,
and in higher dosages, enhanced theta and delta activity with a reduction
in fast frequencies. This profile is similar to piperasine phenothiaaines,
such as fluphenasine.
have found butaperasine

In the clinical studies, its activity is similar to fluphenasine,
in acute and chronic cases. From this point of’view, the implied
limitation to chronic cases appears arbitrary:
fhe difficulties in differential diagnosis is great, and
is
it often impossible to decide whether the patient is acutely ill,
a relapse in a chronic illness, or an acute exacerbation in the
course cf'a chronic illness.
both

Zhe symptomatic

is not specific
these
the limitation is

response to phenothiasines

for schizophrenia, but is related to the

symptom complex. we view

acting in a non-specific fashion, and
thus arbitrary. For example, patients with anxiety often show a reduction
in this symptom, regardless whether the symptom is part of'schisophrenia

compounds as

�_

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.

,_.

,

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-7.

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... .-

.w “my...“

, .'.- .1,

v

m._ N wwrv

T,

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w

3.,

--

n

.-

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.7

PW -,

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.

.

gnaw

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W'WW"

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NW.

.

or a part of an anxiety syndrome; similarly, the sypptom of psychomotor
agitation often responds whether in schizophrenia, depressive psychosis,
or senile agitation.
In

my

experience the decision to use a therapeutic agent
on a clinical diagnosis, but on a symptom profile,

is usually based not

it

and some elements of history. From this point of view,
seems arbitrary
and an unnecessary implied limitation on the decisions of the physician
to continue the labelling restriction for Repoise for chronic cases.
From another point of view, the limitation restricts the
teaching of the use of Repoise. In teaching residents the principles
of psychopharmacology, it is a special burden for the teacher to attempt
to describe the use of butaperazine and note its limitations. It is
much easier to recomend the use of fluphenazine, for which no such
limitation is implied (and incidentally, for which a variety of form-

ulations exist).

I trust

these

comments

are useful.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

Ref:

Therapeutic Studies in THerapy Resistant Schizophrenic Patients.
Cbﬂg. Psychiat. Z;488-493, 1966.

Clinical Laboratory Test Standards in New Drug Trials.
1—8, 1967.
J. Clin. Pharm. &amp; New Drugs,
_7_:

Organic Treatment

of Schizophrenia. In:

A.Freedmand&amp; H. Xaplan (Eds.), Williams
pp. 661-664, 1967.

Textbook
&amp;

of Psychiatry,

Wilkins, Baltimore,

Treatment of Chronic Psychotic Patients with Combined Medications.
Neuropsychopharmacology, Excerpta Medica, Amsterdam, 101601020,1967.

Differentiation of Psychotropic
9:267-—280, 1968.

Drugs by

EEG

Analysis, Aggressoloﬂe

Liquid Butaperasine (Repoise) in the Treatment
Mental Health Clinic. Curr. THerap. Research

of Psychosis in a

_1__1_:

57~63, 1969.

.&lt;~.'—VI'.A.\

�</text>
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                    <text>”W

April 10,

£8:

To when

It

Hay

1972

Robert Sharoff. 3.3.

Concern:

I have known Dr. Robert Sharoff since 19ﬁ6 ~ first as a
co~worker in substance abuse, and lately as a member of the faculty.
At the time I joined his staff, I kaew very little about opiate abuse,
its management or its psychopathology. I found him erudite and willing to teach, not only me, but the residents.

excellent were leader, a fine and patient teacher.
a methodical and careful worker. He is well liked by the staff,

and
and the

he

is

an

patients.

pleased to recommend him for a position of psychiatric
teaching and treatment, and aéminiatrative clinical leadership.

I

am

Sincerely yours,

Professor of Psychiatry
:Eﬁig
cc:

Robert Sharoff, M.D.

�</text>
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                    <text>April 7,

1972

Dr. Jonathan 0. Cole

Bostan State Mospital
Beaten. ﬂasaachuaetts 02124

A

a»!

fkﬂmm

é‘

Dear Jon:

B'L‘u

I very much enjoyed the sessions in drug models of schiz~
&gt;ophrenia at the A.P.P.A. I was stimulatad to summarize some of
the discussion. and cialose a draft for your consideration for the

publication.
My

best regards.
Sincerely yours,
ﬂax Pink,

3.9.

Professor of Psychiatry

HF;ig
Enc.

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                    <text>V‘x,

April 7,

The Medical
10 Columbus
New

York,

Society of the County of
Circle

New

New

1972

York

York 10019

RE:

Oliver Todor Nikolovski,
250 East 87th

New

To Whom

It

May

York,

New

Street, Apt.

York 10028

Concern:

I have

known Dr. Oliver Nikolovski since he joined our
1969. He is well qualified as a psychiatrist, and is
recommended for speciatty rating under the Workman's Compensation

faculty in

Law.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig

M.D.

Assistant Professor of Psychiatry
23C

�</text>
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                    <text>‘W’“WKV‘—l\vnnv'l

--

-

.

\w

n-‘vwm.

.w»

.v—«w

,

.H

r-_'—‘I|‘r-v—-&lt;a(v-

-

’ r’v’lu"wr»vrvl'
-rr'|—..--rr
-

JV“

April 6,

,

‘_m,.n~,w‘

.._

1972

Walter Essman, Ph.D.
Professor of Psychology
Queens Gallege
Dear Walt,

Enclosed is our check in
activities during the past quarter.
Many

payment of your consulting

thanks for your help.

Sincerely yours,
Max

Fink, M.D.

1..“

,

ww.._.,-n-

~',w--|Y

"a”...kmwr 7.

,_....

‘

�</text>
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Dr. Samuel C. Kain

Director. Alcohol

and Drug
Dependenco Service

Veterans Administration
Departmcn: of ﬁedicino and Surgcry

“tubington, 9.6. 20b20
Dear Sam:

Enclosed is a copy of our original levomethadyl protocol
(dated 1/19770) and a suggested one for 1972«73, dated 3/31/72.
In the latter, I have tried to indicate a possible program of in—
terest to the V.A.
'

-

Please feel free to adapt, modify, or use this as you
find useful.
I look forward to seeing yen on April 28.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

3F:13
Enc.

may

�</text>
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                    <text>April 6, 1972

Dr. Samuel C. Kain

Director. Alcohol

and Drug
Dependenco Service

Veterans Administration
Departmcn: of ﬁedicino and Surgcry

“tubington, 9.6. 20b20
Dear Sam:

Enclosed is a copy of our original levomethadyl protocol
(dated 1/19770) and a suggested one for 1972«73, dated 3/31/72.
In the latter, I have tried to indicate a possible program of in—
terest to the V.A.
'

-

Please feel free to adapt, modify, or use this as you
find useful.
I look forward to seeing yen on April 28.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

3F:13
Enc.

may

�Alfred Freedman.

April 6. 1972

M.D.

I haw found Dr. Volavka a fine rasearchcr and teacher, and
a find electrooncepbalogrcphcr. and I commend him to you and the
faculty for promotion to Associate Professor.
A

copy of his curriculum
cud expat-1mm.

to hit industry

vitae is attached.

and

it attest:

Sincerely yours,
ﬂax Fink,

5.0.

Professor of Psychiatry

ﬂing
ﬁne.

�</text>
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                  <elementText elementTextId="103651">
                    <text>nur:

wv

.

.u

-vv-~

~

-"\ nee-Immmﬂ't": -w~»,v.—.‘a-w—»vw»vw~

.

-v-":'.-l-:::-Nv«~.

"Ku'rrvnw'rnvwrr-A‘n

._

w

v

(«a 1-,.» .

~W~

”vow/MN?

wu-

r-mwa: ,

April 5,
Louis P. Bozzetti, M.D.
Commission on Marijuana
Washington, D.C.

&amp;

v w

-&gt;

r

~-

-

'

.

-

.7

u

..

war

w-v

urn-w

-

n

1972

Drug Abuse

Dear Lou,

I have just read the report of the Commission, afetr
the
hearing
special program with Governor Shafer last week, and I
am writing to congratulate the Commission and you for the fine work
that you have done, in putting the marijuana issue in the perspective
that seems to me to be appropriate and necessary. I do agree that the
prominent unknowns are the long term effects, and hope that some of
the studies now underway may answer some of the questions.
appendices.
I

It is
As

know you

will
My

a

fine report,

and I look forward to the

I understand

it,

best regards

and congratulations to Jack as

your work

do as good a job on

is only partially done;

the other problems of drug abuse.

well.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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.e

_,.m,..,.

“.5

“M“.

v

w . ewe,

my. .-_P “.7 ..,.~._.,.,...,r...‘

.

.~

_...,,,_.,_.,..

Hymn.-.“ we...“ WVWLKFW‘”.

-‘wm... “r.

..

“are vim..- -,-_
-

,

i.

.

.w

{-W

BNDD—

April 4,

Department of Justice

Registration Branch,
1405 I Street

Washington, D.C.

1972

Room 711

20537

Gentlemen:
At various times during the year, in conjunction with
grants 18172 and contract h2-70—98, I have imported to the
laboratories in New York, various components of cannabis and
various synthetic opiates and antagonists. In the past, I have
obtained the appropriate import permits, as these were needed.

NIMH

Similarly, on occasion, our co-workers in Europe,
request samples of these substances for research purposes, and
requested export licenses.

we

have

I an writing at the suggestion of Mr. Steven Stacy, to
obtain the necessary registration forms to register as both an
importer and an exporter of proscribed substances under the various
limiting schedules.
BNDD

I already hold,

on behalf of

my

laboratory, the various

certificates for studies of scheduled substances.
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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4

c

.

‘

www-mu

VT.

.u. “WWW".

“1,...- fJ-{C‘PI-r‘-&gt;'~m‘~ unit‘wzrIn" -,....

“We,“

&lt;,

ﬁn

gr

,

April 4,
Henry

Brill,

1972

M.D.

Pilgrim State Hospital
Brentwood, New York

Dear Henry,

I have just completed reading the

first report

of the

Commission, and I want to congratulate you and the other members for
a most balanced, realistic review of the issues and facts, as well
as for the judicious recommendations. It is a fine document, and
I trust the nation and the states will follow the recommendations.
You
My

should feel

justly proud of your participation.

best regards.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

�</text>
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91‘,“

August 31, 1972

ﬁr. Fred stunner
13m

.

59 ﬁaiden Lane

ﬂew

York, New York 10038

Dear Fred:

Following our contract, we are hereby notifying 13% that
the maintenance contract on the purchased 1800 be cancelled effective
9/30/72. Title to the 1800 will be transferred to the International
Asaociation for Psychiatric Research, Inc. and that organization.
requests a maintenance contract effective 12:01 a.m., 10/1/72.

Pleasc prepare the necessary documents for our meeting on
September 6, for release by ﬂew York Medical College and acceptance
by IAPR of both the 1800 maintenance and keypunch rental, to proviﬁe

for ontinued service without lapse.

Sincerely yours,
Me: Pink. M.D.
Professor of Psychiatry

,MF:ig

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                    <text>Angus: 31. 1972

Mr. Fred Stunner
IBM

59

ﬁaiden Lana

ﬂaw York, ﬂaw York 10038

Ben: Fred:
our intention to accept responsibility for the 18H 1800
at 5 East 102nd Street, effectiva 10/1/72. This
be
transfcrrcd to SUNY~Stony Brook later this fall.
cquipment will

It is

and leased keypunch

the

IKE

Please

make up

tha neccsscry contracts for maintenance

1800 and the kcypunch

rcntcl, effective October 1.
Sincerely yours.
Fink. M.D.
Executive Dircctor

Max

on

1972.

�</text>
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                    <text>August:

so, 1972

EEEQEAEEEE

To:

1. B. schwartz

FROM:

Max

SUBJECT:

Attached

The

Fink,

M.D.
PD

attached

PD

Form-

forms U111

transfer staff to

47-072—7, follow—

ing the guidelines of Mr. DcLucenn; use son: ”on campus" funds of

the

KIHH

contract 41r809~lg

and do son: housekeeping

41-382~3 which ends 9/30/72. and providc
and a change

in

my

for

some

to close out

leave for Br.

Crown

status.

Missing 11 ch.

PD

for: for

Dr.

antanaga.

Also. ch. juatificction page: for Mt. DcLucanc (to be added

to rcvitcd budget)

and a request

to hit! a nuts: to rcplacc Hrs.

Thomas.

�Giordano, ruignod to toko position in mother city.
plocuont deferred to Soptonbor.

D.

A.

Thoau promoted to coordinator of inpatient oorvicu.

plnconont roquutod.
B. Riemann)

J. Roldan)

B. Boddio )
R. Mayan )

RoRm-

Rouarch uoistmtu and technician: mignod
during July-Auguot. Replacements appointed
includo:
Loslio Suntan, Pat Sibony,
Carolyn Poinior, ﬂark Koala“. (1/2 time).

L

replace am of the services of A. Thomas, as coordinator
of the cyclazocino trutment program. we have promoted .‘iiso
Frmces Waiter at a higher salary.

To

hov- oxtonsivo data requiring are-programing of our
computer unit. Ho roqunt the addition of Ira Snapper, progrmor
analyst for six months, offoctive 9/1/72.

We

now

-

�</text>
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                    <text>August 29, 1972

Morris B. Bender, M.D.
Professor of Neurology

Mt. Sinai Hospital
New York City

N

Dear Morris,

I very much enjoyed your report on a theory of acupuncture.
I tried to relate what little the popular press describes
about acupuncture to the DSS data, the more I am impressed that DSS
represents a reasonable way to study the process.
The more

of the formation of an NIH committee
enclosed unpublished study. The 1956-1959
quantitative measurements provided a better means of studying D85,
and in 1963-64, when I began to play with a CAT, we designed the
enclosed study to demonstrate the cerebral components of sensory
interaction. We found evidence of interaction in the AEP but could
not relate these changes to reports of extinction of stimuli.
sent

me

to

The announcement

my

The

files for the

exercise does demonstrate a

problem in acupuncture, and

may

be of

way

to study the DSS
you or your committee.

interest to

Good luck in the studies. Perhaps, DSS will yet become
established as the explanation for the"hypnosis' phenomenon which
is now becoming the talk of the psychiatric community.

Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>August 28, 1972

Jouethan 0. Cole,

M.D.

Editor. Poychophermecologie
Boston State Hospital
591 Morton Street
Boston, Hesoechueetto 02124

Dear Jon;

I am pleased to submit the enclosed report, "A9~Tetrehydrocannebinol Effect. on Baum Bleetroencephelogru, Heart Rate, and
Hood" for your consideration for Raychophanmacolagia. In this study.
we have demonstrated an equivalence between the effects on physiologic
measures of smoked As—Tﬁc and marijuana, as well as dose related effects. The study e110 provides evidence of Eacobehaviorel relations
for this psychoactive compound.
Incidentally, I wont to thank you for recommending my eppoint~
went to the editorial advisory board of the journal — I trust I will
be able to support the quality of the reports in the journel.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

Hfzig
ﬁne.

�</text>
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                    <text>August 25. 1972

Frank S. Caruso, Ph.D.

Assistant Director
Clinical Pharmacology
Bristol Lnborntorioo

P.0. Box 657
Syracuse. New York 13201
Dear Dr. Caruso:

Hhilo we are anxious to undortako studios of

BC—ZﬁOSa, we

from the Health and
are required to obtain additional permissionwhich
is being doalt
Hospital Corporation. There is some deity,
we ccnnot
dissolved,
is
impediment
that
with by the Collage. Until
begin the planned atudiao.

Sincerely yours,
Fink. MOD.
frofoooor of Psychiatry

Mix

33:13

�</text>
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                    <text>August 24, 1972
Mr. Gary Boyer

Center for Studies of Narcotic &amp; Drug Abuse
National Institute of Mental Health

Rockville, Maryland
Dear Mr. Boyer,

Ref: Cyclazocine

August 5, we submitted the appropriate FDA 1571,1573,
from Sterling Winthrop, and supporting information
to obtain an IND for the study of cyclazocine at the New York Medical
College to Dr. Edward Tocus, Division of Neuropharmacology, FDA.
On

letters of release

Following a telephone

August 22, I submitted a protocol

you.

call to Dr.,Alan

Ramsay

on Tuesday,

for the study of cyclazncine to

In re—reading your letter of August 8, I believe the
delay in obtaining an IND may be occasioned by the fact that the
information was submitted to Dr. Tocus directly. Perhaps, an
intervention from your office may release the appropriate IND
designation.
Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August 23, 1972

Mr. Gary H. Boyer

Chief Pharmacist
Center for Studies of
and Drug Abuse

sarcotic

Fishers Lone
Rockvllle, Metylend 20852

5600

Deer Mr. Boyer:

Enclosed is a copy of our ongoing protocol for the clinicel
evaluation of cyclazocine 1n the treatment of opiate dependence.
In part, this protocol amplifies the contract, ﬁSM~AZ~72~207 between
ﬁlﬂn and Dr. Alfred Freedman of the New York Medical College.
You

will note that

we have an ongolng maintenance

and e new group being inducted
Thank you

for your help.
Sincerely yours.
Mex

Fink,

M.D.

Professor of Psychietry

Hing
cc: Alan

3133

Ramsey

papuletion;

to high dose cyclezocine (to

20 mg/dey).

�</text>
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                    <text>August 22, 1972
Dr. Jerome H.
SAODAP

Jaffe

The White House

Re; Diprenorphine (M-SOSO)

Washington, D.C.
Dear Dr.

Jaffe,

you know, we have undertaken the pharmacologic testing
of diprenorphine (M—SOSO) to comply with the interpreted regulations
of the FDA, to permit us to assess the clinical pharmacology of this
compound in opiate dependence. We have had some difficulty in obtaining supplies of diprenorphine sufficient for these toxicology studies,
but did receive, this week, 15 grams from Reckitt &amp; Colman-- sufficient
to complete the animal trials.
As

if the

These
compound

trials will be completed by the end
is 'safe', we will apply for an IND,

to undertake the clinical studies in February, 1973.

of the year, and
and should be ready

have been advised by Dr. G. Blane of Reckitt &amp; Colman
that future supplies will have to be obtained from Lederle Laboratories.
When we attempted to obtain some supplies from Lederle in May/June, we
were told that they were disinterested in such studies.
We

believe that the assessment of diprenorphine for opiate
health possibilities. Anticipating difficulty
in obtaining supplies in 1973, I am writing at this time to ask your
assistance and advice as to the best procedure we may follow, to
assure an initial supply of 15 grams for human studies. The availabilitt
of a supply of M-SOSO in February, 1973 will permit us to fulfill one
of the committments of the NIMH contract 42-72~207.
We

,3..-

w,

,.

arr

”my-n.-

dependence has public

Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Ramsay,

NIMH

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                    <text>mmrm mm

_

"5'

‘1'-

August 22, 1972

WWn—v—vmwm—u-wvwrvm—wW"

,.

w-

IV“ Fe Bum.tt, NJ).
ﬂedicsl Research Division
The Lilly Research Laboratories
Eli Lilly and Coapany
Indianapolis, Indiana 66206
Dear Ivan:
Your letter regarding citations of methefrone and nethajade
as trade names for levonsthadyl aroused some anxiety. I checked my
files and than called Herck.

(1) Math-Jade
(2)
E

g

'

Hethefroae

to another

is,

as you suggest. a formulation of methadone.

is not a

Merck trademark. It seems
compound, unrelated to levo-ethadyl.

to belong

Thank you for bringing this to my attention. I believe it
the JANA staff that added the trade naaes to our article. and
should they wish to correct their records, I am sending a copy of
this note to the Editor, Ir. Hussey.

was

Sincerely yours,
Fink. M.D.
Professor of rsyohistry

Hex

HF:ig

cc: Rush Eussay, ﬁ.D.

‘

�</text>
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.mw

——.———..__..m

W.—

...

w—w-p—

—._.—.w

August 21, 1972

Gareth Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Gary,

for the supply of diprenorphine (M—SOSO),
arrived this morning; and I which I immediately
delivered to Dr. WOodard in Virginia, who is carrying out the
Thank you

15 grams, which

pharmacology

trials.

anticipated, the National Institute of Mental
Health and the special office in the White House have announced
the organization of a number of contracts for the clinical evaluation
of narcotic antagonists. The amount announced was $2 million, and this
sum includes some funds for periodic meetings on the subject of
As we

antagonists.

present schedule at Woodard provides for the completion
of the studies by the end of the year; and we should be prepared to
undertake clinical trials soon thereafter.
The

My

thanks for your help in providing

this material.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>August 21, 1972

Horritt

Dr. H. Houston

Association for Rssssrch in

ﬂames

and Mcntsl

722 Wast 168th

New

York,

ﬂow

Discus. Inc.

Straat

York 10032
RE:

Richard Abram; PM).

Merritt:

Dear Dr.

I

msbcmhip
a plasud to propose Richard Abrm,Moots}.forDisossa.
I

in the Association for Rssosrch in ﬂorvous and

have known him since 1968, when ho rejoined tho

"11.1).

staff

as fallow.

intsrostsd in ECT. and bacsns tha projact director of our
evaluations of. unilatoral and bilateral 301'. as nsds important contributions to thst evalustion, and has continued his snthtsissa for
this problem.

Ho

wss

prassnt,
biological studias,
At

ho is sctuslly angagsd in s vsristy of psychoand I an contidsnt ha will contributs to tho

lusting: of the Association.

Sincsrsly yours ,
Max

Fink,

21.1).

Profusor of Psychiatry

�</text>
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                    <text>August 21, 1972

Merritt

Dr. H. Houston

Association for Research in
Serrano and ﬁentcl Disease, Inc.
722 West 168th Street
York, dew York 10032

ﬂow

EB:

Dear Dr.

Merritt:

l have

recommend him

known

for

Dr. Taylor

alrssdy

ﬁichasl Taylor since 1968, and am pleased to
in the Association for Research in Rervoul

membership

and Mental Disease.
who has

Michael Taylor, ﬁ.D.

is

made

an innovative,

inapirtd

young

investigator,

significant contributions to studies of schizo-

phrenia. While a resident, he undertook independent research in the
influence of the sex of offspring on material psychosis. His work
has been highly commanded.
Sines his return from military duty, ho has undertaken clin-

icsl responsibilitiu sndsustsincd his research interests,
cusing on
cxpcrincntcl anxiety.

him

for

I so sure he will contribute to the Association

membership.

now

fo-

and recommend

Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

�</text>
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December 28, 1971

Dr. Hugh H. Hussay, M.D.

JAMA

535 N. Dearborn

Chicago,

Illinois

60610

RE:

REF:

MS

#3263

Dear Dr. Hussay:
have reviewed the data in our study of “t-Alpha—
Acetylmethadol in Maintenance Treatment of Opiate Dependence”
and find that some of the interesting relationships can be presented in tabular form. We have made up such a table, and it
We

is attached.

it

seemed somewhat lengthy, we indicate a section
that can be separated, and the data presented in two tables.
As this is a matter of style and appearance, we will abide by
As

your decision.

Thank you for your kind consideration. I trust that
the reputed excessively high price of the base material for

will soon be reduced, so that more ex~
tensive clinical tests can be done. Publication of this exper—
ience may serve to stimulate a more rapid governmental and in-

Esalpha—acetylmethadol

dustrial response.

Sincerely yours,
Max

Fink , M.D.

Professor of Psychiatry

bﬂﬁig
Enc.

�</text>
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                    <text>November 4, 1971

Dr. Lester King
Editor
.EMA

535 North Dearborn Street
Chicago, Illinois 60610

Sir:

Dear

We

are pleased to submit the report, "l—Alpha—Acetylemethadol
Dependence" for your consideration

in Maintenance Treatment of Opiate
for the Journal.

This study describes similar clinical results for l—slphaacetylemethadol given three times a week to daily methadone. Should
this prove generally applicable, the saving in illicit methadone and

its

consequences can be great.
Thank you

for your consideration.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
70:

Alfred

FROM:

Max

M.

Fink,

The

Freedman, M.D.

DAT;

M.D.

SUBJECT

August 11171972

Attached

attached proposal for a joint study between Dr. Inturrisi and

Dr. Levine

is

a valuable addition to our on-going

studies of

levo—

methadyl.
This information
an

information

is sent to

you

for your files,

and

to suggest that

letter regarding the collaborative study

appropriate College authorities.

be sent the

�</text>
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                    <text>agaaaggaga
Angult 11. 1972

1‘0:

Dr. Robert Levine and Dr. Robot: Ronnie}:

PROM:

Dr,

SUBJECT:

ORDERIHG CYCLAZOCIHE FROM KIM}!

ﬂu

Fink

I have filed the necessary

forms

for

an IND

for cyclazocine.

Paragraph 3. indicates that: future supplios are to be

obtaingd from

Mr. Boyer

at

N133.

Paragraph 4, indicated that Dr. Runny, in to recaiva routin-

clinic reports.
Plane contact Hr. Boys: or Dr.
.

of cycluocine.

Ramsay

far additional suppliu

�</text>
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                    <text>August 11, 19 72

Chairman,

Internship Selection Committee

Dear

Sir:
Mr. Heywood Zeidman

is

known

to

me

as a summer research

trainee. During the summer of 1969 and again in 1971, he participated in the drug studies of this department. I found him to be
intelligent, enthusiastic, cooperative and nighly motivated. He
was enthusiastic about the effects of drugs on brain functions and

worked hadd.

I have seen ﬁr. Zeidman frequently during the
tried to answer his many questions about the
of clinical psychopharmacology. I believe he will be
active intern and should approach his work with skill
and hdve

past few years

special problems
a dependable and
and energy.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST 102M) STREET

NEW YORK, NEW YORK 10029
DEPARTMENT OF PSYGIIATRY

August 10, 1972

Nathan S. Kline, M.D.
Research Center
Rockland State HOSpital
Orangeburg, New York 10962
Dear Nate,
Once again, I must agree with you. It would, indeed, be
a most unconstructive expenditure of our funds, for the State of
New York to re-assess the many unsupported claims of ortho—molecular
therapies. The megavitamin approach is so poorly documented, and so
dependent on parallel and concurrent therapies, particularly ECT
and drugs, that the burden of proof should remain on its proponents.
The probability of exploitation by the proponents is indeed
and
I concur in your request to Ben and to Alan, to put the
high,

State's funds to better use.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Miller
CONFIDENTIAL:

Not

for Distribution

�</text>
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                    <text>x
&lt;-.~,

7'

-.
w

,—._-

w.

an”,

August 10, 1972
yww‘wwavmwﬂ-JW-n

Allan Ramsay, M.D.
National Institute of Mental Health
Rockville, Maryland 20852

ewaquup4m‘n

Dear Allan,
-vu-.r.wa-

N,

nag-'3'

..a:a,,.g.—~

Separately, we have filed an IND for cyclazocine for the
on-going studies at the Metropolitan Mental Health Center, and I ahve
requested Dr. Levine to institute the proper procedures with Mr. Boyer
to sustain our supplies. He will tell you that we are treating about
80 patients daily, and while the majority are receiving 4~5 mg/day, there
are at least 12 who receive 8—11 mg/day, and we are proceeding in a
few to 20 mg/day.

Paralleltstudies of Z~cyclazocine are in progress. For
the present, we have adequate supplies, but these should he exhauseudd
within three months.

file

for chyclazocine, or will MIME
provide us with the supplies to continue the ongoing studies under our
Should we

new

contract

of the

FDA

a new IND

?‘

If we should file an IND, will you request the cooperation
regarding the extent of the submission ?
Will additional supplies be available through Mr. Boyer or

from Sterling-Winthrop

?

Meanwhile, we have hegun the study of haloperidol; the
animal pharmacology of diprenorphine is delayed by supplies from
England, which have been promised for later this month; and the study
of BC-2605 has been delayed by an administrative problem, which we feel

will

be resolved by the end of the month.

Thanks, again, for your help.

Sincerely yours,

:_.

ZV'N-aq

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>August 9, 1972

David S. Haskell, M.D.

Senior Psychiatrist

The Commonwealth

of Massachusetts

Department of Mental Health
591 Horton

Street

Boston State Hospital
BostOn, Massachusetts 02124
Dear Dr. Haskell:

be in

fer

I will be in Europe until August 21.

On my

return, I will

York and can meet with you on any Tuesday or Friday. I pre8/22, 3/25, or 8/29 as in September I will have additional comNew

mittments.

Please call my secretary at 212-369-7900 (ext. 245) - let
plan to come, (10 a.m. at 5 East 102nd Street, 8th

me know when you
Floor, Room 33).

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

iﬂhig

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                  <elementText elementTextId="106485">
                    <text>August

7 , 19 72

Mr. Gary Boyer

Biomedical Section
Center for Studies of Narcotic
and Drug Abuse

sational Institute of Mental Health
5600 Fishers Lane
nockville , Mary land

Dear Mr. Boyer:
To

provide parallel information in New York for our studies
we request the following addition-

of cannabis constituents in Athens,

al supplies:

CBD

CBN

(crystals)

5 mg/amp.
(SSC 69780)

24 amp.

10 mg/amp.
(SSC 61565)

12 amp.

Deltae9—THC

3 amp.

(SSC 69682)
1 gm/S ml/amp.

The
Many

appropriate

BED—222 C

form

is enclosed.

thanks .

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:ig
Enc.

�</text>
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                    <text>August 9. 19Y2
Mrs. Roberte London
Contemporary Drug Problems
515 Oxford Street
Wentbury, ﬂew York 11590

Dear'ﬁra. London:
The suggestions by Sennela, Hoehetetter. end the

mittee (Contamporery

Drug Problems)

Lari?

Con-

for e heroin delivery experimﬂnt

are well motivated, but they do not consider the severe practical
problems posed by the suggestions. In selecting heroin. they select
the drug with greatest risk (high lethality for dose), shortest do»
ration (requiring moat repeated administrations) and least stability.
They propose an experimental

patients

who have

delivery in

failed other treatment programx.

livery is to provide

all patients

trial for heroin

100

to

200

The heroin de~

a method of engagement, and within the

year,

are to be admitted to other treatment programs, partic«

ularly narcotic antesoniets, methedone, or drug-free.
The principel benefits of the program will be the incorporetion of a small additional group of addicts into a prevailing treat~
meat regiment (which, presumably, they bed once before

as a vague

test of the British experience.

rejected);

and

�.hm. uoberta London

August 9, 1972

base proponents cannot be
homework,

for

moving done

for besides the questions that are raised

moral, legal, and
from the

commended

historical grounds, I

would

raise

practical Ipharmccological) point of

View.

on

their

social, ethicnl,

some

questions

Heroin, morphine, methadone, and levouethadyl represent feur
compounds

(Opioidsl

they are most similar in

on a continuum:

their

patterns of physiologic and behavioral effects it man and animals.
They exuibit patterns of crosantolerence, for each can substitute
for the other, and each
achieve cos

may

be given by any bodily

raute

and

still

effects. Their principal difference lies in their dura-

tion of action, with ueroin'e effects lasting the Shortest, usually
from 3

to

6

hours, and levomethadyl the longest, from

36

to

48 ﬂours.

duration is important in selecting appropriate dosages, for
with short acting compounds, physicians have the most

difficulty in

for their patients.

Thus, in see

stabilizing rue effecto they

wish

looting heroin. the authors opt for the most difficult and most ex‘
pensive delivery system.
we

and from

it is

have had extensive experience with heroin

that experience
and

pleasant bodily effects.
and unusual changes in

recall

it's

other problems for heroin:

We

propenoity to produce a variety of unhave observed

seizures (convulsions),

heart rate, respiration.

sufficient irregularity as to lead
patients with caution.

two

stability, requiring careful handling for

a compound of low

sustained efficacy;

can

administration,

us

and senaorium with

to administer heroin in our

�Hrs. Roberto London

prevailing

A

Anguet‘S, 1972

View

of drug dependence emphasizes the

signifi‘

cance of conditioning and learning theory an the basis for etiology
and as a key

to the alleviation of the

In suggesting e here

syndrome.

i

oin delivery system, the author! disregard this
one method of

cipel advantages of

this paradigm have merit.

methadone has been

its

However, should the authors wish

repeated injections,
adone, which

select the

edninietretion, the repeated intravenous, that will

enhance dependence, should

route.

View and

why

One of

the prin~

usefulness by the oral

to engage their patients

by

have they not recommended intravenous meth-

is achieving

some vogue now

in Brithin,

and has the

ad—

vantege of a longer duration of action and less frequent administra—

tion?
Granting a successful delivery system for heroin to a select
group of

patients,

what

is the anticipated gain? That these patients

will be available for after—care programs, of methadone and cyclazocinel
If that is the real goal, to reduce crime by buying these patients to
participate in the eyeten,

would

it

not he more to the point to

more

adequately finance and increase the number of treatment programs so

that

more
The

patients

can be more adequately

reed selected by Samuel: and Hochetettcr is one that is

easy to recommend, but for

potholes.

treated?

Should

this reader.

their enthusiasm for

one

that is full of rut:

engagement not

they would consider the expansion of levonethedyl1

and

pale, perhaps

trials

es e more

�mw‘

are. Roberta

August 9, 1972

London

logical substitute for heroin
for

Don

and methadone; or

if their

enthusiasm

Quixote causes can be sustained, they coy investigate the evi~

dence for the development of a long acting narcotic antagonist.2 Such

a development has theoretic, therapeutic, and prophylactic possibil-

ities to

commend

from public

it,

and

yet is receiving the bares: of attention

authorities, while

much eneggy

is dissipated

on the pro-

motion of heroin delivery.

Sincerely yours,
ﬂax Fink,

3.9.

Professor of Psychiatry

MF:13

1.

Zaks, A.,

H.

Fink, and

i.

E. Freedman:

Treatment of Opiate Dependence.
2.

Iink, H.: Treatment
giarcotic Antagonists.

Levomethadyl

J.A.M.£., 220:

in Heinteuance

811—813, 1972.

and Prevention of Opiate Dependence with
Contemp. mug Ptoblema.

�</text>
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              <elementText elementTextId="53213">
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  </item>
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                  <elementText elementTextId="106486">
                    <text>,

-

arm-Vauyr-errw—w-

VZJELAPTI

July 17,

1972

Samuel Gershon, if. D.
Department of Psychiatry
New York University College of
Medicine
550

New

First

York,

Avenue
New

York

Dear Sam:

to organize the equipment needed for the EEG
monitoring of high concentration oxygen effects in aged patients at
NYU.
To provide some basis for instructing my staff, can you provide
us with a provisional protocol, so we can fill in some methodologic
details we have found useful (§;§,, duration of prewdrug mecording,
electrode location, alertness monitoring, tape identification, amplification of signals, £33.).
be able

We

may

If

no protocol

exists,

can you share the following:

rype, age, condition of subjects (cooperation level)

dumber and frequency of experiments

Duration of each exposure
Period after exposure subject
chamber (and

available for

will remain in

EEG).

To save a few days, send me a copy
Long Lake, New York 12847.

to c/o General Delivery,

Sincerely,
rialt Fink ,

Eli. D 0

Professor of Psychiatry

Ming
cc: Jerome Levine, M.D.vf

oxygen

�</text>
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                    <text>Octdber 30th, 1972
Donald Klein, M.D.,

Diractor of Research,
Island Jewiah~ﬁillsidelaueens Medical Center,
270-05 76th.Ave.,
Haw ﬁyde Park, H.Y. lloho.
‘

Long

Dear Don,
;

;

Folioving our discussions at the research committee
this morning, I would appreciate you asking your secretary
to aenﬂ to me, for filing and/or distribution:
(a) copies of protocols a! cngoing research
programs which may be made a matter or
record at this time.

g

(b) invitations

to meatings of a raaearch nature

~

the lattar to be aistributed to tbs committee
and to othar dapnrtmwnt members.

g

z

Sincerely yours,

Ml: Fink. N.D.,

Professor of Fsychiatry

g

M?/1J

�</text>
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                    <text>§

October 30th, 1972
Sidney

ﬁbrils,

M.D..

Prcfessor or Clinical Psychiatry.
Central 13119 State Boagital,
Central 13119, K.Y. 11722.

Dear

Sid,
Following our diacunsionn

this morning, I

to send to

ma,

would

at tho research committee

appreciate your asking your secrdtary

for filing anﬂ/or distribution:

(a) caplet of protocols or ongoing research
programs which may be made a matter of
record at this time.
(b) invitaticna

the

and

to maetinga of a research nature

latter to

to

~

ba distributed to the committee
ether departmnnt nnmbara.

Sincerely yburs.

Fink. M.D.
Professor of Paychia$ry
max

NF/iJ

�</text>
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                    <text>Octobar 30th, 1972
A1

Rankin. Ph.D..

Clinia:l Research Branch.

Hational Iantitubo of Mhntal He‘lth.
5600 Fishers Lana,
Roekville. Mhryland 20852.
Deur A1,

the recent EEG mnetings, I had the occanion.to disauas
projects with various workara, inaludins Whiter
Obrébt az Duke. He in ‘aquainted with the cardiovascular
and can: of the aerebral offoctu of hypafbnrie chambers.
It may be useful for yuur project to revicv his work.
At
Queuing

Thu wanting; also aurfuood name advances in portrayal
of result: that arc buuaming inerigaingly aw‘ildble. and
which may improvn ycur proposed studies.

Bincarely yours.

Fink, M.D.
Profasnor of Psychiatry
Mhz

mm:

�</text>
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                    <text>&lt;-‘-

,.

A-

Octdber 30th, 1972
..y-wv,wcmnw.wu,wwmwv

Dr. Steven Khmgater.

Ilka Fifth AVQ.,
ﬁew York, N.Y.

Dear Boater Kempster.
'

At

the vrittan'roqnost of Hrs. Earriat

anclosing a copy of a

Vinita to

me

summary

1957~1960.

Axmun,

letter rogsrding her

I

am

81n¢erely yours,

Fink. M.D.
Profeasor of Psychiatry

Mix

33/15
Rue.

~m‘w-nww.

m

«rm-I

A

�</text>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Correspondence</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Correspondence to: Kempster, Steven</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Text</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="53256">
                <text>mfp-05-00-026-4-270</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="53257">
                <text>1972 </text>
              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="53258">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Correspondence -- Correspondence</text>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="53260">
                <text>The Max Fink Collection</text>
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          </element>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="53261">
                <text/>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="53262">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="53263">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="79528">
                <text>en-US</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="86089">
                <text>application/pdf</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="92650">
                <text/>
              </elementText>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="99211">
                <text/>
              </elementText>
            </elementTextContainer>
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    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
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</itemContainer>
