50
100
6561
-
http://exhibits.library.stonybrook.edu/mfp/files/original/2a4db07198c6bf3c84d2847d3174a848.pdf
cb05b7ac8bfd859519bad6801a246549
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Text
December 17, 1971
APHA
1015 18 St NW
Washington, D.C.
20036
Gentlemen:
I
am
interested in the following W.H.0. publications:
# 19
WHO
ExpertiCommittee on Drug Dependnece,
WHO
Special report on Cannabis, dated October or November,
1971
I would be grateful if you would quote the price for
these issues, and others related to drug abuse or cannabis.
Thank you.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
�
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December 16, 1971
Dr. S. J. Mule
80 Hansen Place
Brooklyn, New York
11217
Dear Sol,
Enclosed
is
my
reiprt, EEG
Henry Brill
ETTEOts of’Drugs of’Dependbnoe,
and yourself. I regret the extra
volume edited by
delay but I hope the data presented justifies the qeiting. I would
be pleased to have your comments and suggestions for modifications,
should these prove useful to the overall design of the volume.
for the
My
best wishes for the volune's success,
happy and healthy
New
Year.
and
for a
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
�
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"navfimizm‘m
«—
_x
n
r-n
V
m“.
.,_.,w—u—r—u'm
w—m warn.
.
vw.
V
‘
mun
.
,
raw“
u.,-
[rs-raw
nr-"~',—-'rVr
.. v ”duh".-
..
v
v. .m.
*‘ “UV—r-
-~-
ww—r
v
m
.— m-I
--
an."
. q
.»
U'JW
‘nrqwc..._~
December 16, 1971
Arthur J. neikman,
15 Muir Avenue
M.D.
Mill Valley, Calif.
Dear Dr. Deikman,
with some
on Bimodal Consciousness
because you focussed on EEG evidence for
I read your report
interest, particularly
the concepts. The references to the EEG patterns associated
with the two modes of consciousness were illuminating. When the LSD
phenomenon was discussed, however, the EEG data was presented
ambiguously. The EEG effects during the EEG state are well defined,
an
exhibiting a shift of the mean frequency to a higher frequency,
of
(periods
with
seconds
'drop-outs'
increase in the number of
and delta activity.
flattening of EEG activity), and a decrease in thetamode
would be in
action
the
would
that
expect
Using your model, one
mode.
of
the
receptive
force, but the description is that
some of
is the state of delirium. In this
patterns are those of increased fast
state, the characteristic and
theta activity, and a decreased
frequencies, increased delta
The
subject is active, restless, and
responsivity to eye Opening.
outwardly, in the action mode; but the mental state is so severely
dissociated that it would be best to identify the state with the
Another problem for me,
EEG
receptive
mode. I think.
Finally, you will be interested in the recent data presented
by Itil and Ulett on the problem of EEG changes in hypnosis, and the
ingestion
reports of the EEG changes with acute cannabis inhalation and
and
decreases
which show increases in the alpha percent time,anplitudes,
in fast frequency.
Perhaps, in a later presentation, these data
integrated into the concept.
may
be
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
P.S.
My
best to
Dave Metcalf when
next you write.
�
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1971
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//f
-
_//’1
pecan”.
December ]S, 1971
‘Jnn'ur-r-
-
.e—r—.;mwww,w-—a.r
Mrs. Roberta London, Mg. Ed.
Contemporary Drug Problems
515 Oxford Street
Westbury, New York 11590
.wmmwmw“””””
\~em.
Dear Mrs. London,
W's-"fir”,
I have re-written the article on opiate dependence, under
the title, Treatment and Prevention of Opiate Dependence with Narcotic
Antagonists, and sent it to my typist, for delivery to you early next
week.
It is sent on the understanding that it will be included in the
1972
issue.
Spring,
As I discussed, it may be useful for your editors to con—
the
sider
invitation to some of the scientists interested in the
of
problems
drug abuse to your Board, and I suggested that you
consider Dr. Alfred M. Freedman, Chairman, Department of Psychiatry
of this College, and/or Prof. Stanley Yolles, Chairman, Department
of Psychiatry, State University of New York at Stony Brook. Both
these men ahve a long history of interest in the problems of drug
abuse and have maintained a balanced and theortically sound position
on most of the contemporary issues.
of Cannabis, will require
that for the antagonists. There
is so much research activity at present, that to be timely the article
should be prepared at the latest time possible to meet your deadlines.
Depending on the time of the year, you should re—extend your invitation
The
other
re-writing even
article,
Biology
more extensive than
about 10-20 days before the final deadline.
difficult to meet your request.
Good luck
It
should not be too
in your endeavor.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
�
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67b3d93de01a61e876421d6a312c8fda
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December 14, 1971
Dale Cameron, M.D.
Commissioner on Drug Abuse
W.H.O.
Genera, Switzerland
Dear Dr. Cameron:
I
was very much
activities in
interested in your report
Your comments regarding analgesics
from Janssen were most helpful — I
discussed these with him, and we have agreed to share our data.
and
Mexico City.
on W.H.0.
antagonists available
I am enclosing some reports from this laboratory, of
our studies of the use of narcotic antagonists in opiate dependence, and the central effects of acute and chronic cannabis use.
The cannabis studies are in progress in New York and Athens, and
we have a proposal to extend the study to Jamaica.
Many scientists and clinicians from many countries have
visited our laboratories, and should W.H.0. desire to extend their
training activities, we would be pleased to participate.
Again,
my
thanks for the suggestion about Janssen.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
Ming
Enc.
�
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W»
Dacsubar 14, 1971
Paul Jansaan, M.D.
Janssan Pharaacautical Raaaarch
3-2340
Bursa . Bulgiua
Dear Paul:
It
Haxico City.
was a
Ha
plassura to boar your rsport and most you in
ars particularly intarsstad in narcotic antag-
ouiata. and art soaking a compound or formulation of long duration
with minimal agonistic fasturas. Dr. Canaron of tha W.H.O. suggaatad that you may have davalopod antagonists of high potancy
without agonistic fasturas.
If such coupouudo do sxist. I would be grateful for any
infatuation ragardiug their characteristica and availability for
study.
Should you praiar, you may wiah to bring such data to
the sttantion of our spacial drug abuse agaucy ~ Dr. Robart Rosa,
Spatial Action Oftica for Drug Abuas Pravantion, Whita Hausa,
Washington, D.C.
Any
ssaistanca you can giva our search (or a nora useful
ha appraciatsd. My boat rsgards to your charming
antagoniat will
Hits.
Sincsrsly youra,
Fink, H.D.
Professor of Psychiatry
Max
“:13
cc: Dr. Hobart
SADDAP
3...
�
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mfp-05-00-025-9-560
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1971
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—~-
uncut-cm
.
u-
December 11, 1971
Dr. Paul Arcese
Sandos Pharmaceuticals
Hanover,
New
Jersey
Dear Dr. Arcese,
I have
read your
letter of December 8.
In our study of 5-42, 548, we assessed the EEG and behavioral
effects of single doses in normal mle volunteers. There were no
patients in the study. Also, we coupleted the pilot, 'dose-finding'
study only, and our recommended study of 5—42, 548 vs. placebo was
not done.
It is
probable that the synptoms reported by these men
related, or may have been a result of the situation.
The study is incomplete with regard to the definition of this
judgement. It is not possible, therefore, to list any of the
effects as ’sids-effects;,-nor is it possible to esclude the possibility
thta these reports are drug related.
may
have been drug
I am
therefore returning the reports-— first, because they
'; and secondly, because the required judgement of
drug related, not drug related, or uncertain cannot be Inade.
specify 'patients
Sincerely yours,
Max
Fink, MD.
Professor of Psychiatry
�
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1971
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rw—w—“Wm
w mu -w
-
,
December 9, 1971
be».
Stingley
Stratton
Fifth Avenue
Grune
111
IJew
5'
York City
Dear Mr.
Stingley,
Encloud are the corrected galleys for the Introduction,
Question Md Answers, and the reports by Abrams, Dornbush, Fink,
Small ‘3 Small, and Volavka. Only the reports of Pitts and Essman
remain to be corrected and returned.
discussed, the Q & A requires some special handling.
We would prefer the questions to be set off from the answers, and
this may be done by set ting the questions in bold face or italic; or
the Q and A before each paragraph can be reset in bold face. At the
least, there should be additional spacing between each set of Q a A.
As we
Secondly,
I was chagrined by
the high price charged
by the
reprints, and I am enquiring whether a special price
publisher for
be
arrived
of each article,
can
at for a single order of 100 reprintscontribution.
each
his
author
in
to
I
by
for
me,
gratitude
paid for
would appreciate your response. Alternatively, if reprints were not
ordered, but whole issues, what is the price for additional copies
100
to the Editor
7
I will send the two missing galleys as soon as they are
received from the authors with their sometime.
'
Many
thanks
for your assistance.
Sincerely yours,
Mas:
Fink, M.D.
Professor of Psychiatry
"mu—WM
.
�
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Deconbor 9, 1971
hirooni Iohlzakl, 5.2.
Instructor
M.D.
Doparrnon: of Neuropoychiotry
Knnooi Modicsl School
Oooko, Japan
Door Dr.
Inhizoki:
I regret that we are unable to process any opplicotious
for positions in EEG rooearch at the present time, and trust you
will be able to find a position in Germany or the Soviet Union ~
both countrtloavhioh are actively seeking students.
Sincerely yours,
Ha: Fink, M.D.
Professor of Paychiotry
HF:13
�
Dublin Core
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mfp-05-00-025-9-563
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1971
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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en-US
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/8846c367c182229626d7814b9796e940.pdf
6ebe25f4f05756f2f0917403d564d1a4
PDF Text
Text
Danube:
To:
9,
1971
Sylvia Faulkner
m: m Pink,
my.
Plano "NEW the maintenance contract for the Pridcn calculator
for one you, affective 1/1/72
Charge (46-12241)
W.
@
$110.
�
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mfp-05-00-025-9-564
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1971
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/e59498f2b33d27f77adad229e0d6d55d.pdf
273f73d29d4f6f04839c35b50cc1a1aa
PDF Text
Text
Decauber 9, 1971
Dr. Margaret Tripp
45 Canbridgc Road
Colchostcr, Essa:
England
Dear Dr. Tripp:
the
would appreciate a copy of your curriculum vita: and
of at least two reference: to whom we may write. We would
We
names
prefcr lottera
and
psychiatrists.
There are openings in this Department at various times,
I will do my best to process this application in time for the
spring
_
April
from
1
or
Thank you
Hay 1.
for your intarcst.
Sincerely yours,
Mar Fink, E.D.
Professor of Psychiatry
HF:13
�
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mfp-05-00-025-9-565
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/7fca95783d6341efc037b0b3e93ef1bf.pdf
b013cdc8136774bb37a5ad9140e80895
PDF Text
Text
Decauber 9, 1971
Dr. Margaret Tripp
45 Canbridgc Road
Colchostcr, Essa:
England
Dear Dr. Tripp:
the
would appreciate a copy of your curriculum vita: and
of at least two reference: to whom we may write. We would
We
names
prefcr lottera
and
psychiatrists.
There are openings in this Department at various times,
I will do my best to process this application in time for the
spring
_
April
from
1
or
Thank you
Hay 1.
for your intarcst.
Sincerely yours,
Mar Fink, E.D.
Professor of Psychiatry
HF:13
�
Dublin Core
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Correspondence to: Roth, Martin
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mfp-05-00-025-9-566
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1971
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/b6f38c9542f18ca00c41ddc617b0a690.pdf
428aa3ac1a71283816d0b6fef1de2996
PDF Text
Text
December 9, 1971
Mr.
Stingley
111
Fifth
Grme s Stratton
flew
Avenue
fork City
Dear we
Stiflgl‘y,
Enclosed are the corrected gallsys for the Introduction,
and
Question
Answers, and the reports by Abram, Dornbush, Fink,
Small 6 Small, and Volavka. Only the reports of Pitts and Rattan
remain to be corrected and returned.
special handling.
and
the
set off from
Wars,
bold
be
in
done
by setting the questions
this my
face or italic; or
the Q and A before each paragraph can be reset in bold face. At the
least, there should be additional spacing batman each set of Q 6 A.
As we
we
discussed, the
Q & A
would prefer the questions to be
requires
some
I was
chagrined by the high price charged by the
reprints, and I an enquiring whether a special price
publisher for
be
arrived at for a single order of 100 reprints of each article,
can
paid for by me, in gratitude to each author for his contribution. I
would appreciate your response. Alternatively, if reprints were not
ordered, but whole issues, what is the price for additional copies
to the Editor 7
Secondly,
100
send the
I will
the authors
received from
Many
two missing gallsys as soon as they are
with their corrections.
thanks for your assistance.
Sincerely yours,
Mac:
Fink,
31.1}.
Professor of Psychiatry
�
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mfp-05-00-025-9-567
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1971
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/b5a92b38a44ff5b54c0a37de9ea24ddc.pdf
27b6bf1219820145b8cf98df0b0044bc
PDF Text
Text
December 9, 1971
Dr. Robert Rees
SAODAP
The White House
Washington, D.C.
Dear Bob,
are pleased to enclose a protocol for the study
of narcotic antagonism
of l~cyclazocine~- to assess the degree
in post—addicts, and the relation of an effective 'therapeutic'
while we will be preoccupied with
dose to secondary effects.
we believe
our studies of naloanone pawste during the next few weeks,
the middle
about
beginning
we can evaluate this compound concurrently,
of January.
This protocol will be submitted to the appropriate
committees of the College for their concurrence, but we anticipate
We
no
difficulty.
Should the supplies be available,
is a choice) to
have
we
would
l-cyclasocine presented in the
scene
(if
there
concentration
prefer
and the scene vehicle as racemic cyclasocine. If manufacture is no
problem, we would request an initial supply of 1200 mg» sufficient to
assess the effects in 8 patients for 4-6 weeks.
Many
thanks
for your cooperation.
Sincerely yours,
Max
Fink, MD.
Professor of Psychiatry
mf/
V
:rar
:
.
�
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mfp-05-00-025-9-568
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1971
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/de80284a24664d3b41c66be91e3b5ecc.pdf
ef436edb6824c510ccca02d14bf28b04
PDF Text
Text
December 8, 1971
T0:
135
FROM:
Max
SUBJECT:
Space at 102nd
space at
I
am
Fink,
14.1).
Street
writing to request your review of the allocation of
Street.
102nd
When
Dr. Crown joined
my
staff, it
was only possible to
office to share with Dr. Volovka because Dr. Feldstein
my
service. Since he shares an office, both he and Dr. Volovka
left
rotate their time here, with one frequently doing his work at the
Academy or at home.
assign him an
Dr. Marvin Glasser is an appointee to NH 13358. When he
worked on the 4th floor he was able to participate directly on my
work. Since August, he works in Valhalla, and is of little use to
me
or
office
my
associates.
Similarly,
—
a
when Dr. Shapiro comes
possibility only if I leave.
to
New
York he uses
my
Drs. Taylor, Abrams, Levine, and Gaztanaga are interested
in working with me. Since space at Metropolitan is not available,
and none here, we carry out our discussions by telephone - a procedure that is of little use.
I request the assignment of rooms 34, 36, 27, and 29 to
the Division, for as many months as we remain at 102nd Street and
until another resolution at 106th Street or MHMC is found.
�T0:
December 8, 1971
IBS
Personnel at 102nd Street
Professional
ResearefiiAssistant
R
Crown
Full
Time
Greenberg
Full
Time
Dornbush
Full
Time
Komlosi
Full
Time
Tolavka
Full
Time
Maxym
Full
Time
'h'aynor
Full
Time
Richman
Full
Time
Glasaer
3 Days
Pavel
Full
Time
Shapiro
2 Days
Garcia
Full
Time
Fink
Full
Wells
Full
Time
Abrams
1 Day
Snapper
3
Taylor
2 Days
Levine
1 Day
Time
6.8 Full Time Employees
(McNiff)
Days (FT
Evening
if
Glasser
were here)
7.6 Full Time Employees
�
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mfp-05-00-025-9-570
Date
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1971
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/4ca6b5cf169a325172a8c45793a3c9d0.pdf
e93f0d4c1139cec7ab0f7b5d59dccaba
PDF Text
Text
December 7, 1971
"‘0 :
IBS
FROM:
Max
SUBJECT:
Service Functions,
On
and
Fink,
M. D .
Ward 15A and OPD
basis, we admit 400 patients for observation
these, about 100 receive further treatment,
continue in our aftercare program.
an annual
detoxification.
on methadone, and
Of
The detoxification procedure follows the established
techniques of reducing dosages of methadone, requiring 7-14 days
observations. Aftercare consists of meetings with rehabilitation
counselor, social worker, and education Specialists, as well as
individual
older,
and
and group psychotherapy.
Admission
is restricted to males,
residents of
New
York City.
18
years of age and
The average a patient stays for detoxification is 9 days;
for methadone 60 days; and cyclazocine 30 days. Outpatient stays
varies for 1 month to 6 years to date.
During 1971, we regularly cared for 100-110 patients in
seen on the average 2—4 times each week. A sample month
runedown (March, 1971) is attached. In addition, we respond to
consults regarding drug abuse on 123, l3ArB, and all of metropolitan.
the
OPD,
H03pital.
,tgg14
r m.
7-.
,n.’
.4.
.Vt.,.s_..ea- .i
1‘5“»:
a».._":§$‘
ar...
7'.
¥
�TO:
188
those on
December 7, 1971
The
~
professional staff treating these patients includes
rate of $199,081. (List attached).
067, at an annual
In addition, the research staff, supported by ME 18172,
19176, 13358 and 47—072 Spend varying amounts of time in the studies
on 15A, including heroin-antagonist research, cannabis, and EEG.
On an annual basis, these sums are:
S
47—072
Personnel
2 15A
257,123
69%
13358 (41-382)
39,700
10%
18172 (41-435)
44,300
40%
19176 (41—452)
28,164
50%
(Est)
�STAFF AT 15A
-
MET ON
067
Annual
Geyer
Social Worker
$10,560
Orlin
Social Worker
11,890
Psychiatrist
14,666
Gaztanaga, P.
Psychiatrist
20,000
Jones, T.
Internist
12,600
Levine,
Psychiatrist
25,000
Maior, V.
Psychiatrist
19,250
Montese
M.
H. Worker
7,865
Resnick, R.
Psychiatrist
14,000
Clare,
G.
R.
Reuben,
J.
Psychiatrist
19,200
Taylor,
M.
Psychiatrist
25,000
Psychiatrist
18,050
Zaks, A.
TOTAL
$199,081
�
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Correspondence to: IBS?
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mfp-05-00-025-9-571
Date
A point or period of time associated with an event in the lifecycle of the resource
1971
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/c344ec351f0b990e2c4f39dcc240fbb7.pdf
55a6c1c5d4f84eb47252acb83d8114b3
PDF Text
Text
December 7, 1971
3r. Jerome Levine
PsychOphermacology Research Branch
national Institute fientel Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear
Jerry;
Your suggestion that we hold A ”working session“ on
the subject of quantitative EEG and psychophermecology is excellent,
and I will prepare as detailed a presentation as may make the
discussion most useful. In thinking about participants, I had e
number of suggestions.
From psychopharnacology
I believe Jonathan 0. Cole should
be present, since his interest and enthusiasm has sustained
program since its inception.
this
For a formal knowledge of EEG and drugs, Peter Kelleuey
of Houston, Robert Ellington, and George Ulett are highly qualified
elactroencephelogrepners who arc not now active in drug evaluation.
Turan
Enoch Galloway, Charles
Itil,
active interest in EEG and
have an
Shegess, and Arthur Sugornen
drugs.
general psychiatry, I would suggest Seymour Katy,
Jool Elkes, aorton Raiser, and Denial Freedman be
From
Al Silvoruan,
considered. none have e formal knowledge of our work, but their
roles as ”generaliets" ia well defined. I anticipate they would
be Both interested and contribute to the review.
From clinical psychophamcology, Prita Freyhan, Heinz
and
Leo Rollieter ere activo clinicana who have a broad
Lehmann,
interact and experience. Leo has had e special interest in EEG
and has consistently failed to find the correlations we have re~
ported.
�Dr. Jerome Lorine
Decaubor 7, 1971
Along the statistically sophisticated with a special
knowledge of the problems of reducing large scale data, you may
considar Allan Miraky (Boston). Ron donate, Dean Clyde, John Overhas had a special interest in EEGall, or San Sutton. Kiraky
knowa
bchavior ralationa, he
our work, and is an intoreated critic.
thin type of work, Abraham Hinkler
should be considered. It was his 1952 theory that set no on thin
study route. Since then, he haa criticized my data, noting that
we "ovar—aiuplify" a vary complex subject. He has not dedicated
as Inch time to quantification as 1:11 and I, and in 1966 he participated in tho anticholinergic drug symposium with much enthuFinally. the
aiaam.
“daan” of
‘
I look forward to this session with great interest.
Sincerely yours,
m:
Fink, 3.2).
Professor of Psychiatry
Hing
�
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1971
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5492f6a5c3ed7439fc9bbaf3783b8c76
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Deco-bar 6, 1971
Ivan K. Goldberg. M.D.
929 Park Avenue
New
York,
flow
York 10028
Dear Dr. Goldberg:
I an grateful for your invitation to participate in
racording for the Behavioral Science. Tape Library. It is unclear
to no vhat subjects you with represented, nor is it clear what
bonafita may accrue to no for my services. The work of this division
is very broad, encompassing ECT (both clinical and experimental),
opiate dopandencc thorapy. cannobio effects (acuta and chronic).
and BBC offoctn of psychoactive drugs. Such a progran is actively»
pro-outed at national and international meetings, and could servo
the library.
However,
it
is not clear
how
this lecturer
may
benefit;
not is it claar whatnot the talks are to be proacntod informally
or formally. Perhaps you may wish to consider another financial
arrangenont, an a fixnd sun for the nation and a lesser "royalty"
for aach subscription?
Sinoaraly yours,
Max
Pink, H.D.
Protaalot of Psychiatry
HF:ig
�
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1971
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6aa4a7f87a09210f7ff2757022ffbf6b
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Docsabsr 6, 1971
Dr. Garry F. Blane
Rsckitt & Col-an
Hull , England
Dear Garry:
Ho bass rscsived the supply of storphins.
undsrtaks our studies rapidly; many thanks.
We
will
Thsrs is much enthusiasm for an sscslation of rssaarch
in the narcotic antagonists. Ha hsvs, this vast racsivsd a supply
of naloxons psaosts for study; and l~cyclasocins is now in suffi—
cient supply for human trials bsginning next south. I an opti—
aistic that we will obtain funds for toxicology, sufficient to
file
an IHD.
Again, sy thanks for your hslp.
Sincsrsly yours,
flax Fink, M.D.
Professor of Psychiatry
3311;
�
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1971
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617b9e96d8cb2b0010050c7e8bdc11a4
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December 6, 1971
Dr. Stanley Feldetein
2700 Ken Oak Road
Baltimore, Maryland 21215
Dear Dr.
and
reldatein:
Voita has kept very busy with the EEC-cannabis analyeee
is finding very interesting correlations. Indeed.
claina that there
may be an EEG—behavior
correlation!
he now
The heroin project has been held up by a shortage of
heroin, but I wrote to Jaffe in the White house and sea told the
eupply would be available on Monday. The project will then start.
you, but
I not Kurland in
is
Mexico City and he remembered meeting
he
heels
not sure
help.
Encloeed is the health and accident policy it the as~
satiation. Should you viah thia coverage after January 29, you
may
elect to continue.
I here received my pilot'e licenae - and it has given
Inch
pleasure. I was fixing today and look forward to an excuse
II
in the spring to visit Baltimore.
My
best regards.
Sincerely yours,
Max
Fink, H.D.
Professor of Paychiatry
MF:ig
Enc.
�
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mfp-05-00-025-9-575
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1971
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bf3fcecb8fc635c0087128bbbfd4c5df
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Deco-bar 6, 1971
Dr. Ivsn Bennott
Ely Lilly Company
Indianapolis, Indiana
46206
Dear Ivan;
Enclosed or. copies at my requeot to Karo: Bentonnn
reply. If you can support our request, perhaps you would
sand those on to Avram Gold-coin with your con-onto.
and hi5
Many
thanks.
Sincornly youro.
Max Fink, M.D.
Professor of Psychiatry
MI:13
Inc.
�
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1971
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60bbaf891ae7256e0a1f63d00d38d2b1
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Decaubor 6, 1971
Arnold
J.
Mandall, M.D.
Profoaoor and Chairman
Dopartnant of Psychiatry
Univaraity of California
P.O. Box 109
La
Jolla, California
92037
Daar Arnold:
It waa kind of you to writa about 8-2809, a bill sponaorad by Senator Tunnay. I had read thia bill before and found
its intant coat worthwhile. Tho meant, however, carry two potential (and unnecessary) pitfalla - a focus on a limited number
of ragioual contort, and tha incroaaad focua on a political aourcc
of control, notably the white House.
copy of my roaponaa to Senator Tunney is enclosed for
inforlation.
At this time, support for the aatabliahnant of a national
A
your
institute for drug abuse raaaarch and training seams to be sorely
noadod. Sanator Tunnay'a bill ocean to diffuae tho energies foam
this important effort.
Hy
boat ragards .
Sincoraly yours.
Max
Fink. H.D.
Professor of Psychiatry
Ming
Ibo.
�
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1971
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1f7fedf99ef595c904a214c91552ca3f
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Deco-bar 6, 1971
Ir.
Seymour Piahar
Univoraity Hoapital
750 Harrison Aronua
Boaton, Maltachnootto 02118
Dear Seymour:
Enclosed are copioa of the Quootiono and Annuora portion
of the forthcoming icauo of Shainaro in Poyohiatiy devotod to
ECT, aa raquaatod by Ernest Hartaonn. I have no objection to
your tending this draft to several interoatod workers. with the
idea that their comments may appear in a later issue of Seminaro.
As an oxporinont, it cocoa quite
look forward to the comments.
interesting,
and
Sinccroly youra,
Fink, H.D.
Profoacor of Psychiatry
Max
cc: Brnoat Hartmann, H.D.
I
�
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1971
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55fff0ae17d20ff81ee27aa314cb95e2
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‘
\\
December 6, 1971
Mrs. Barbara Gibbons
College Department
Holt, Rinehart and Winston, Inc.
383 Madison Avenue
New
York,
New
York 10017
Dear Mrs. Gibbons:
my
I have received your request for permission to reproduce
1970 on narcotic antagonists in a popular
reprint of September
volume by Matheson and Davison.
This summary is incomplete as a reflection of the role
of narcotic antagonists in opiate dependence. Perhaps a more
complete summary, appearing in the American Journal of Nursing
(71: 1359—1363, 1971) or another in press, may be more useful.
If you will send a copy of the table of contents, it may be helpful to decide my response to your request.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
�
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mfp-05-00-025-9-579
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1971
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December 6, 1971
Dr.
Christer Meissner
Ciba-Geigy
AG
Basel, Switzerland
Dear Dr. Meissner:
Enclosed is a copy of my report to the World Congress
of Psychiatry, and an earlier report which describes more fully
our latest findings. I trust these will be helpful.
and
I
Our studies of GP—41299 will be completed by February,
hope these will be interesting.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max
Ming
Ehc.
�
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mfp-05-00-025-9-581
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1971
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Dscssbsr 3. 1971
Dr. Jerome K.
Jaffe
SADDA?
white house,
Washington, D.C.
Dear
Jerry:
Roger called me about the problems in obtaining supplies of
cannabis and opiates for research. Our difficulties are long standing,
and are of two kinds * "approval” by an FDA-NINE Connittee that has ar-
roasted the responsibility to review the specific content of the uses and
to which applicants for drugs are making of their requested supplies;
actual distribution difficulties.
Since 1968,
we
have had approval from 31MB,
BNDD,
H.Y.
States
College to study cannabis
3.1. City, and the appropriate committees of our from
scientific committees
and heroin in man. we also have fornal support
[psychopharnacology],
(N.Y. Stats flacc~contracts since 1967; Nlfifi 13358
18172 [cannabis], and 19h76 [heroiu]l(
Yet, when we request supplies of cannabis, us are again asked
supplies
to submit formal proposals for committee review. Not only are
the Con—
of
the
prejudices
reduced
to
according
and
the
aaounts
delayed
their arbitary decisions. For exnittee, but our intent frustrated 21bydays
of marijuana use in man would
ample, in June we were told that
dsensd
not be allowed, but 7 days would be; and in September, the Committee
made
in
21 days allowable for all investigators. Such reviews are not
the
any other drug study we usually depend on the investigator to assess
the
by
risks and the needs of the study progrsn, and rsquirs monitoring
appropriate connittsss of his institution.
—
It is
ny
belief that the
Committee ought
to restrict
its
func~
tions to advising the Secretary of HEN about the distribution of those
drugs which are in very limited supply - to evaluate the priorities among
of the nation.
scientists who nay have special calls on limited assetsshould
be freely
the
distribution
ample
supply,
But where drugs are in
made to those scientists who have eat the standards of research and infor which drugs
stitutional monitoring approved for the specific studies
pious reaare requested. The assumption by the Committee, for whatever
to drug
deterrent
severe
is
a
of
proposals
the
content
sons, to critique
study.
and
fruitful
inhibited
and
both delays
research,
�Dr. Jerome K.
Jsffs
Deceabsr 3, 1971
Tho sscood issus is that of the supplies. Ones spprovsl is
tho
givsn,
suppliss srs distributsd in obtuse snd sxpsnsive ways, with
suppliss dslsysd and lost. On two occssions, horoin hss been sent through
the osils sod hsvs been lost. Prior to the roosnt sssusption of distribution by BRDD, ths drug was dalivsred by so sgsnt of tho Justice Departssnt sod whils it took months to obtain suppliss, thsss did svsntuslly
arrive. flow, it tskss months to 3st sporovsls and suppliss come only
site: rspostod cslls.
Incidentally, so sro embarking on tbs spooisl study which you
othsrs hsvs rsqusstsd that of tho duration of action of ssloxons
pssosts. Us hsvs no hsroin on hsnd, sod dsspits roqussts since tho sod
of August, sad submission of tho oscssssry docuosnts, us will be forcsd
to carry out thsss ssssys with inputs substancss. Porhsps your attics
could call BNDD sod srrsnss for s ship-sot of 1 Grss for the iossdiste
uss, psoding tbs usual longthy procsss for 5 Grsoo?
and
—
Sincsrsly yours,
Pink, M.D.
Professor of Psychistry
Max
33:13
�
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mfp-05-00-025-9-582
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1971
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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http://exhibits.library.stonybrook.edu/mfp/files/original/31faa94747ed3fb22e97e5871fcd0086.pdf
32008792e2aff9e23ee9888df129e5a8
PDF Text
Text
Docenbcr 3, 1971
A. Grace
Picrcc,
H.D.
Associate Director of
Clinical Rasearch
Ortho Rnsoctch Foundation
Raritan,
New
Dear Dr.
Pierce:
Jersey
08869
1 look forward to seeing you on Wednesday morning at
I have received the description of ORF 8063 and look
forward to discussing this with you.
11 a.m.
Much of our work is focused on a dcscription of the
chanson induced by psychoactive drugs. In anticipation of
our discussion, I an mending you'two recent summaries of our
work.
EEG
Sinccrtly yours,
Fink, H.D.
Profcocor of Psychiatry
Max
31:13
lhc.
,
�
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mfp-05-00-025-9-583
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/da0f33e36d2f2a21831d7b1e3ef77e79.pdf
18fc2294611501539a82d8b1162541cd
PDF Text
Text
Docenbcr 3, 1971
A. Grace
Picrcc,
H.D.
Associate Director of
Clinical Rasearch
Ortho Rnsoctch Foundation
Raritan,
New
Dear Dr.
Pierce:
Jersey
08869
1 look forward to seeing you on Wednesday morning at
I have received the description of ORF 8063 and look
forward to discussing this with you.
11 a.m.
Much of our work is focused on a dcscription of the
chanson induced by psychoactive drugs. In anticipation of
our discussion, I an mending you'two recent summaries of our
work.
EEG
Sinccrtly yours,
Fink, H.D.
Profcocor of Psychiatry
Max
31:13
lhc.
,
�
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mfp-05-00-025-9-584
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/a05f94573fcd29b86008b128e8b63a88.pdf
d3f04c8db75bbaef1214780a7d358163
PDF Text
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March 31, 1972
Jean Paul Smith, Ph.D.
Division Narcotic
&
Drug Abuse
fiational Institute Mental
Health
Fishers Lane
Rockville, Maryland 20852
5600
Dear Jean:
all our reprints relating to diprenophlina
enclosed.
capies are
We have sent 10 fit::;?fi*5050 to fir. Woodard for animal
toxicology studies.
I otzfizrlhe
will be helpful.
He
(fivSOSO);
have collated
reprints
Sincerely yours,
Max
Fink,
M.D.
Professor of Psychiatry
HF:1g
Enc.
�
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mfp-05-00-026-1-029
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/8a66e91489db600dbcfa9c7cf8ae70e0.pdf
20674d177c2ce91d3c095adb0e465b05
PDF Text
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flarch 31. 1972
Dr. Sidney Archer
Sterling winthrop Research
Institute
Reusaeleer.
flew York
Dear 51d:
thanks for your hospitality and the fine dinner on
I have already written Bob about the changed concentration
of cyclazocine, and discussed with Al Freedman our possibility of
finding the animal toxicology of £~cyclezoc1ne pamoate (or enonthato).
Should we get any encouragement, we plan to ask you to plepare this
material for us.
Monday.
Many
'
I also enjoyeé our discussion of antieen31ety agents. Per~
haps you would be interested in this small reprint. As it was re”
troapoctive, we were unable to assert we have observed tolerance
development, but I believe the data supports such a View.
fly
best regards.
Sincerely yours,
flax Fink. M.D.
Professor of Psychiatry
53:15
�
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mfp-05-00-026-1-030
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/e438bec820e585e0706070f0ac18935d.pdf
80db991fbce94a0d810637eb8f3e7d3b
PDF Text
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fiarch 31, 1972
Dr. Geoffrey Woodard
12310
Pinecreat
Road
ficlndon, Virginia
Dear Dr. woodard:
files, we found the enclosed reprints and
us by Racket: & Colman in 1970. These may be useful
in your evaluation of H-5050.
In checking our
raports sent
The letter of authorisation
sent earlier this week.
we
look forward
ta hearing
and our supply of M—SOSO‘wére
from you.
Sincerely yours,
Fink. H.D.
Professor of Psychiatry
Max
flF:1g
Enc.
�
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mfp-05-00-026-1-031
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/a1552f19ef742f352d1d33fd3ca3e0e0.pdf
01361dcfe300f8a44970d58ecf68275e
PDF Text
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Hatch 30. 1972
Dr. William Blackmore
Sterling Winthrop Research
Institute
Reusaalser,
flew
York
Dear Dr. Blackmore:
Enclosed are case reports of patients inducted in 1971,
to be added to our files at the Institute.
Sincerely yours,
flax Fink, ELI).
Professor of Psychiatry
Mfzig
Ens.
-,
n.‘
�
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mfp-05-00-026-1-032
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/e0f1bbc98f08ef2ac1b12a17deacfc66.pdf
36f5f7118ee24a7813a433df4948d6d6
PDF Text
Text
Matéb 28, 1970
Thomas McClashsn, &.D.
Program Head
HIMH - RM. 9m101
5600 Fishers Lane
Kockvills, fisrylsnd 20852
Dear Dr. Mofllsshsn:
associates
anticipate our participation in tho
invastigstors in Spring Grove.
1 do not know if we are ”due" for an individual presentation. If
so, the enclosed summary will be elaborated.
Hy
and I
June 5, 6 meetings of the
Should
stract it)
it
for the
ECDEU
not be "dun". you
ECDEU
Intercom.
may
wish to use this (or sb~
it be appropriate, I would be pleased to send this
to the present list of active ECDEU investigatiors and committee members, if you could supply as with this limited list of
Should
summary
nsmss and addresses.
Many
thanks.
Sinner-1y yours,
Ha: Fink, fl.D.
Professor of Psychiatry
HF:ig
than
�
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mfp-05-00-026-1-033
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1971
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http://exhibits.library.stonybrook.edu/mfp/files/original/e583fb51d99d96732585fe8ec73c4cc5.pdf
a5470e3284af1d210fac37b1aef15952
PDF Text
Text
-., ‘4’
-1
,
,
w .V ,... ,4 Fuvvrv 'Vmw,lr.“fme-v‘mnrt"n
n"...
and
...-,
«.
_.~...wv.¢.—.v_-_ wavfl'.’r--;_
.....
.,
.r w,
.V V.» ..
\vrwdr‘J-s-(uxwr'w-z
-»-..
mu» .m.»
»-.~~ ‘1
March 27, 1972
Donald Gallant, M.D.
Professor of Psychiatry & Neurology
Tulane University School of Medicine
New Orlean, La. 70112
Dear Don,
I read your impressive ECDEU report with interest-~
particularly the data on GR? 8063 and the neurophysiologic studies.
But one issue stood out, that of the EKG effects of thioridazine.
You report extensive and persistent EKG effects of thioridazine and
meaoridezine. In our studies in St. Louis, Turan and I were also
impressed with the EKG effects of thioridazine, in fiber studies of
chlordiezepoxide and thioridazine.
This data becomee even more important when we review the
data
clinical
for thioridazinc, for this compound is no better than
other ontipeychotic drugs, and occasionally has been rated as worse.
Why,
limited to the
then, is the drug not withdrawn; or, as with iproniazid,
few cases of confirmed therapeutic failure with other agents
ECDEU
Perhaps the
group could discuss this question in Spring Grove
in June, and if other investigators agree, bring the data to the attention
of the
FDA.
Or, do you
changes are so trivial as
functions in these patients!
feel that the
not to affect the cardiovascular
EKG
I look forward to seeing you in June.
Sincerely yours,
Max
cc: gerome Levine, M.D.
PRE-NIMH
Fink, M.D.
?
�
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mfp-05-00-026-1-035
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1971
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Match 27. 1972
0:.
Leo E.
Hollistor
Veterans Administration Hospital
3801 Eiranda Avenuo
Palo Alto, California 94304
Dear Leo:
the cannabis oynpooiun
will be plotted to participate in We
1972.
will provide an
of tho 813? in Copanhagon. August 17,
We
abstract
in
to be provided
on the forms
by Dr. Jacobson.
can prepare a printnready manuscript for Copenhagen.
August within space limitations you may suggest.
We
to than.
As
Dru. Stefania and Hires. I have soot your questions
Thoy should answer you shortly.
for
For tho
listing,
our presentation should be
"Behavioral and
EEG
TXIC"A"9" o
titled:
Effects of fiaxijuana and
mxflm,&m,LVdmh,mm,quMWMMPmm.
M.D.
M.
Frooéman.
and A.
Department of Psychiatry,
title
list:
The
you
York Hodicol Collego
and co-authora of the Stofanis«fiiro3 prosontation
should be deforrod.
may
flow
Provisionally (subject to thoir approval),
"Studios of Chtooic Hashish Users"
Costa: Stefania, M.D.,
A.
Liakoo. M.D.,
Costco Miran, H.D., and Mn: Fink,
University of Athens Ind
Row
Md).
J. Boulougoris.
York Modiool Collage
M.D..
�Dr. Leo E. £10111:th
March 27, 1972
I look forward to this interesting session.
Sincorcly your! .
Max
Fink.
24.1).
Frofenor of Psychiatry
14ng
�
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1971
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usxonannux
March 24, 1972
Mrs. Ebert
T0:
—
EH34:
Dr. Max Fink
SUBJECT:
Painting
As
per our
memo
Maintonance
of March 15. requesting painting of room 42A
and Lab 42A; please add to
5;, to b. painted in the
this request,
same color (very
room 42 and Agboratogz
light blue).
Charge 39-270-0.
‘.
.
'l.\.u
.—
,-V.‘.\4
‘
MiaLh—h‘
‘
I
*Wkflgifiw
�
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~¢ w
Julian
an
«mmyvflww? rsavrm»
,-——-‘—'7- -
K
«ww—
«rm-«paws-»-mwv-n.-rmwrnwrwwwmnr
vw4
v
w
Eof:
""1me
Dear Jack,
w:
n—u-
”win-VW'.‘
W.Vv—¢A
.
WW
Wu...
.—
om,
y'w
--
ww-V ,r
~
"W,
,
.
EXHER
M323152~01
AM lo the proposal, ”Malamute of Schizophrenia by
E .3" has imartmt and interesting goals, the methods
".7,me
wuw—
-
March 23, 1972
E. Laoky, Phi).
Hational Institute of’Mhntal Hoalth
Bookv’llle, daryland
.
.
wvw-va,
Regressive
are
inadequate to tho task. Should film Committee wish to encourage such
a program, it would lo advisable for the investigators to diamos
two isouao with otz‘zoro: tho lrztomlatimzo of modifications of the
363‘ prooeoa to therapeutic outcome, and the; isouaa in quantification
of the EEG. In Million, since the min «Issues in regrosoivo EC'T from
a public hoalth point of view are the long Mm affects of multiple
seen as an aaeault on the central nervouo amt-om, particularly
“lama,
on masuree of brain Motion and on such oapaoitloa as concentration,
mmry, and thought prooooaoa, the evaluation of nouroZOgloal deficits
and poyoizologéoal taste focusoad on what is usually called ’organioity’
must be considered.
“.I-vv‘wrrnr—y
investigators have done an interns ting clinical study
in oohiaophranio patients. There is a need for such
a ra-evaluatt‘on of regressive 3‘02”, for this modification has a chequered
history. Older atudiee fomd it rarely useful. Recent studies of multiple
of mgroealve
‘
,
am
mzwwnmvvvmwmw
«A;
A-"fiz'sv
362’,
The
EC?“
under oxygenation control,- kave indt'oatod
safe, pmduaing no
that multiple
ECT
are
mmry lose, nomlogioal deficits, or EEG
changes than slnglo E63". Unfortunately, multiple E02” only occasionally
produces better results than Mingle ECT in depressed patients. Tho data
for schizophrenic patients is unclear, hmwr; and than now are some
reports of better results: with multiple E’CT. Thaw data mantra verthe proposal 2):; Row:- warrmta some
ification, and in this
assistcmann its present form, it is inadequate to the make outlined
by the investigators, and suggostod by my view of the public health issues.
more
erk,
favorable features of the proposal:
is adequate, and the setting is probably a good one for
such studios. (In our investigations of ECT at Gracie Square and Hillside,
was in those small hospitals that the staff were favorably diaposed tp
it
EST, allowing the investigations to proceed.)
The
1) the population
2) The investigators have an
interest and
some
experience in rograsaiva
EC’T.
�EXNE’HOOIOIIOOIOCOOOOODCOIOOIOOQII
2.0.00.00090000. We}: 33’
1972
3} 2%3 PI ochibits statistical and doeign sophistication, and his
rocord as pcychomotrist is good.
Ifio negative fhaturoc
of'tho proposal:
1) The aeaign is ECT vs. drug treatmont. This £8 not the most important
locus, but were it the doslgn to be followed, there are specific problemc.
2)
change
Wfiile the evaluation mothodc may be adoquato lndicoc
in porconallty and behavior, the issue in gogroacivo
ECT
of
is the
impact on lntorporoonal behavior, neurological dcflcltc, thought
processes, momory, and cmontraoion. In their first study, they
emphasize a porcictonce of’somo of’tho thought disordcr~u but is
it difforont and how is changed ? The clinical aspects seem inadbquatcly
covered, and the omphaois on a psychiatric interview no less than 30
mdnuteo and no more than 45 minutoo is mochaniotic and loos than helpful.
it
ovaluction is at thoworong time for any important
ghoulfi be evaluated coriatlm (weekly) to assess
tho rate and dogroo of’chango in brain function. But wool critical
is the likolikood that the patiouts will all rooeivc drugs aflor the
treaomont oourso. Yfio druggcontrolc of'nocoocity; the EC? patients
most probably. Slfioo no statcmont is modo about the specific drugs,
dosages, and relation of EEG measuroa to drug intako, I have to asaumo
the investigators are not acutely awaro of'thc impact of'drugs on the
EEG. To unravol EEG effocts of ECT from drugs without attention to
the controls necessary, is exceedingly dlfflcult.
Ifio
EEG
issue. Porhaps the
EEG
ffie samo problem in the evaluation and followmup will
what {a the impaco of’drugc given after
EU?
tho
EC?
on
rogroacivo
prococc, and on the compariaoo of'ECT and
drugo 7 (For thio reason, I would favor rogrosolvo ECT vs single ECT).
occur for other indicoc~~
Patient selection is
3)
XII-Mr.
,
an
issue.
The statement of’procoas
doccribad are too nan~spcciflc
schizophrenia is inadoquato.
tests
to help othera define tho population. It were better for the investigators
to specify which criteria of’prococc schizophrenia thoy use (3.9. Fish,
Eoylor, others ?). Paychological tests are supplementary~~ they cannot
be used as the diagnostic critcria.
Too
criteria
on
while I'am not ordlnarily prone to question selection
ethical groundb, in this instance, the authors should be
asked to make clear aomo of'thcir minimum criteria of’prior treatments
and failure, recent treatmont and failure, etc. bcfbro rogrcssivo ECT.
Should not all pationtc have had a course of”rcgu&ar' ECT and failed ?
Poychological teats arc given heavy emphasis, but the
more selected in not indicated.
Why the MMPI and the SRSC ? Noithcr is aulecicntly speciflc in its
interpretation to be very helpful.
4)
theoretlc bass from which these touts
�EXNEktiiofiioIOODOOOOOCDIOOIOOOCO
3
OUOIOQCOOOOOCO‘IOIOOWh
I)
There are many problcma with the
the ctudy could be done without EEC moaaurcc,
EEG
33’ 1972
measures, but cincc
I will not
go
into full
datail of’thcinadbquaciac. It to not clcar why the invcctigatorc are
measuring E33 affccte, for the only specific suggestion comoc from the
dhscriptéon of’lack of’abncrmallty bcfbro and after troatmont, as
evaluated by tho neurologists on visual lncpcction. Etc issues
that could be investigated are the difycrancca in EEG offhctc of
rogroscivc EU? to other EZflk the rate at which the induced changes
disappear; the relation of‘changa to improvement, to memory cffhctc,
or to other neurological indlccc.
They cuggcat quantiftcation cf'thc Efiflg suggesting
rocording and analysis for chart epochs. Tfic equipmont they
request, rcprccenttng a large part of'thc budget, to adoquatc only for
the analog to digital conversion, and some simplc ctcpc of'data reduction.
But EEG data it voluminous, coon when reduced, and the interrelations
among many chancclc a horrcndouc tack. (Ihdocd, vary for investigators
have challenged more than one or 2 channel data, and tf’morc, only for
1 0r 2 minute cpochc).
8 channel
Their interest in sleep EEG to unjustified in the protocol.
cbcn suggest sleep EEG recording (8 hours), for 8 channels (I),
to so voluminous a tack, tkat I cucocct tlcy do not moan this.
suggestion about doing visual analytic of'tha sloop records to
interacting, but this too to a big task) and will not in thctr
for cares, answer any of’tka quattcac. The same problem of'drug
control must be considorcd hero.
Eb
thir
I
10
l
4
1h rcwrcadfing thic proposal, I believe the investigator
bringo to the questions, posed by his clinical colleagues, and cxpcrlcncc
at a clinical psychologist and psychometrtctan. Those aopcctc scam well
handled. For ’ccicntlfic' reasons and interacts, they are suggesting
EEG analyses, sleep recording, and some fblloa~up studies. It these
aspects, they team to lack experience, but alco cuffictcnt judgmont to
visualize the tasks and to obtain advice. Earhapt, more they encouraged
to visit and work with one of'thc untoercity based centers studying
EC? and on: focuccad on quantification of’thc EZEQ these issues might
become clearer to them. ware they then still interacted in the studies
auggoatcd here, a better propoaal might (?) to fbrtkcomtng.
to a clinical
better atatamcnt of the
population, assessment of'ncurologtcal chhcto, control of'ECT paramctarc
and drugc, ctc.~« and a contribution madc to the EC? literature. In the
Alternatively, the dcctgn could
replication of their pilot study, with
some
be reduced
latter case, the budget could to subjected to rcqorktng; dblcting
sleep and statistical consultants ($8300), equipment ($30,300), and
E36
chart paper ($600); with additions for neurological evaluation.
I trust those comments are helpful. you already know the
laboratories
interacted in those iccuac, and I am confldont
principal
that any would be interested in this study.
Stnccroly yours,
Max
Fink,
MI
D.
�
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mfp-05-00-026-1-040
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1971
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March 20, 1972
Hr. Abram Engelman
Conference Coordinator
Co-director
Center for Social Research
805 N. Charles Street
&
Action
Baltimore, flaryland 21201
Dear Mr. Engelman:
We have read with interest the announcement of the con~
ference examining methadone substitution therapy. Because we have
been seeking alternatives to substitution on drug—free programs,
we have studied the possiblilities oianarcotic antagonists. Since
the announcement is cryptic, it is not clear to what extent the
examination of methadone and its alternatives is socially or clin—
ically motivated. Should the focus be clinical, we would be inter—
and would be able to discuss two issues:
ested in participating
—
1)
Pharmacological aSpects of methadone and long-acting
methadols (alphamethadyl) in maintenance.
2)
and issues in the treatment of
with
narcotic antagonists.
opiate dependence
Clinical experiences
Should these be of
participate.
interest,
one of our
associates can
Sincerely yours,
Max
Fink, H.D.
Professor of Psychiatry
Ming
�
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mfp-05-00-026-1-044
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1972
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March
20'
1972
Professor Edward Carrot:
University of Florid:
Goinosville, Florida 32601
Dear Dr.
Garrett:
As a member of ASCPT, I received an announcement of the
Third International Symposium on Clinical Pharmacology in Rosanaburg, Germany to August. I am enclosingoan abstract entitled
"Classification of New Psychoactive
for your consideration.
Drugs by
EEG
Profile Analysis"
Thank you.
Sincerely yours.
as: Fink,
21.23.
Profosuor of Psychiatry
�
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mfp-05-00-026-1-045
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1972
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’Jv
««U5
March 16, 1972
Dr. A. V. Bacueta
Aaaiatant Protaaaor of Neurology
and Physiology
Duh: Univnraity Medical Center
Durham, North Carolina 27710
Dear Dr. Eacuata:
Thank you for the kind invitation to chair a workshop
on ”EEG of Drugs of Abuse" at the October meeting of the American
EEG
Society in Houston. I have invited the following participants:
Everett Ellinwood,
Turan
Itil,
Jan Volavka,
H.D.
M.D.
M.D.
flax Fink, M.D.
it will
Anphetaninaa
Benrodiaaepinea,
Barbituates
Opiates, Cannabis
LSD; Summary
while this will not "cover“ the variety of drugs of abuae,
highlight none of the conunnalitiee and the effects of
tolerance development.
It is our intention to summarize the EEG effects of acute
administration, differencea (if any) on chronic administration;
dosage relations; and antagonists(if any). The phenonnnon of
tolerance and cross-tolerance will be described.
It will
'
need a 2" x 2"
slide projector.
I look forward to seeing you in October.
Sincerely yonra,
Fink, M.D.
Professor of Psychiatry
Max
Mfzig
cc: E. Ellinvood, T-
Itil.
J. Volavka
�REG
Evarott Elliuwood,
Turan
Itil,
0?
DRUGS
0F ABUSE
Associata Professor
Univsrsity School of Modicins
M.D.
Duke
Professor of Psychiatry
University of Missouri School
of Modicins (St. Louis)
H.D.
Assistant Profsaoor Psychiatry
Jan Volavka, H.D.
Max
Fink,
Nan York Madical Collcga
Professor of Psychiatry
M.D.
Now
York Medical College
The workshop will raviaw tho affects of alphstaninas.
bansodiasapinas. barbiturates, opiates and cannabis on 356:
acute and chronic administration, toleranca and cross-tolerance.
antagonists,
and dosagc
relations.
�
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mfp-05-00-026-1-047
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1970
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http://exhibits.library.stonybrook.edu/mfp/files/original/769f27dd4b0165c75bd4083ff6b67bb0.pdf
087a8b95c54e5478680584951dfdd611
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Text
MEHORAHDUE
march 15, 19 72
TO:
Mrs. Ebert
F3024:
Dr.
SUBJECT :
Painting
Max
--
mint-none.
Fink
'\
We
paintadhgi
appreciate having room 42A and
\
tow
days
beginning
be
for
a
free
laboratories will
Lab 62A
would
\15‘.
The
butch 28, to finch 31.
He
would
like it to be painted a lightlz tinted blue.
Charge 89-21043 .
‘t
\\ \
».\
�
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mfp-05-00-026-1-048
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/163cb7556332ae6f18b61e60f92a053f.pdf
1c8cfb2cea28df8b46b78770c9f42d19
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March 15. 1972
Dr. Monique Brenda
Division Narcotics and Drug Abuse
National Institute of Mantal Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear Monique:
I an enclosing
our ongoing studies.
two 3RD forms 222—C
(or drugs needed in
are requesting 5 grams of recrystallized heroin to
continue our heroin challenges in studying the duration of action
We
of specific narcotic antagonists.
I
also requesting crystal (dry) cannabidiol, cannabinol,
We are examining the urine: of the volunteer:
of tne cannabis study and the cooperating chemist, Dr. Walter
Essnan, needs these pure substances as standards for analyses.
A—THC,
and
am
A«9—THC.
Thank you
for your cooperation.
Sincaraly yours,
Max
Fink, M.D.
Professor of Psychiatry
HF:ia
Enc.
‘cc: Dr.
R.
Peterson
�
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mfp-05-00-026-1-049
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1972
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19d387ddf3203047f7fb09b9fa23b370
PDF Text
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Avg-"tn
Match 11, 1972
Stanley Yollen, M.D.
Professor & Chairman
Department of Psychiatry
SUR23§tony Brook
Stony Brook,
New
York
Dear Stan,
It gives me great pleasure to recommend the appointment
of Khan Dotnbush, Ph.D. to the Department. I have known her for almost
four years, and during this time she has made extensive and valuable
contributions to my studies of ECT and cannabis. She is particularly
involved with cannabis research at the present time.
She has chm
record and the experience to be considered
for the academic rank of Antaciate Profeencr.
Initially, funds for her appointment will be available
anticipated grants, particularly the transfer of ME 13358,
my EEG study program. I would anticipate, that should her
appointment be approved, that she will establsih her own study pro~
gram in cannabis research, and I would be pleased to assist her
applications.
from the
which is
In addition to her appointmant to the Department of
Psychiatry, I believe she could make a valuabla contribution to the
work of the Department of Psychology, and would suggest that she be
considered for a concurrent appointment in that Department.
Many
.—
:‘r
thanks.
Sincerely yours,
.,mt'.t‘,aor-Man,.-,u"-r
r
«
tn,
-—.m-
Fink, M.D.
Professor of Psychiatry
Max
...
mf/
�
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mfp-05-00-026-1-050
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1972
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ca0b7e6a698a15f01f233c0287893b6d
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P-
we?
March 10, 1972
De. Daniel X. Freedman
Professor and Chairman
The University of Chicago
Department of Psychiatry
950 East 59th
Chicago,
Street
Illinois
60637
Dear Dan:
It was a pleasure to discuss the opiate antagonists as a model
for the treatment and prevention of Opiate abuse, and it may be useful
to outline some issues of interest.
Neither cyclazocine nor naloxone, as now formulated, are prac—
of opiate dependence. At best, we have
been able to sustain a select group of Opiate users with cyclazocine
for up to 5 years, and some are now drug free __ but the number is small,
and I believe our success to be as much a result of the dedication of
my staff as to any specific pharmacologic activity.
But these experi~
ments demonstrate that the antagonists provide effective narcotic blockade; that they are safe; and that tissue tolerance does not develop to
the antagonistic actions. They also indicate that drug delivery ~~ a
sustained delivery of weeks or months -- is the immediate hurdle to
overcome. As the bnger duration of action of methadone and levomethadyl
make maintenance therapy feasible, so too, a prolonged
acting antagonist
would make both deconditioning and phophylaxis clinically realistic.
tical in the clinical treatment
From this point of View, there are thcee practical problems:
the development of a long-acting delivery system; identification of
more potent additional 'pure' antagonists, of greater duration of action; and, biochemical synthesis methods to assure an adequate supply
of medication.
,crn
�Dr. Daniel X. Freeman
March 10, 1972
-
1) Long-action. There are many routes that can be examined
substitution of a long~chain fatty acid to delay absorption and degradatiOn (similar to fluphenazine enanthate and naloxone pamoate); modified crystallizations (as utilized by Janssen for a long acting antipsychotic drug); investment in a biodegradeable silastic (as suggested
by the Population Council for anti—ovulatory agents); or other novel
altered delivery systems as developed by some ingenious chemists for
ophthalmic drugs.
We
have supported one study of silastic and defined the charmethod using naloxone as the base. The study was
acteristics of this
discontinued for lack of funds. It warrants continued support, despite
the long term nature and potential expense of the investment.
We
have also completed
observing that
6
initial
human
assays of naloxone pamoate,
cc intramuscular prolongs the duration of antagonism
diacetylmorphine/chlZ minutes (a 'heroin challenge') to 60
an increase in duration of at least 15 times. This salutary
demonstrates
the feasibility of the approach.
step
to 25
hours
mg
—~
A long~acting 'pure' antagonist. 0f the tested drugs, nal—
the
'cleanest' compound, hut it has many disadvantages a" its
is
duration of action is 2—4 hours; it is ineffective on oral administra—
tion (we required 3.0 grams to extend duration to 24 hours); and it is
expensive and difficult to manufacture, limiting its supply. Other
compounds warrant testing, and of these M 5050 has the most promise,
based on animal trials. To test this compound, it is necessary to first
complete adequate animal toxicology. (This step has precluded human
2)
oxone
assay for more than 2 years, for no agency which we approached was will—
ing to provide the funds. Happily, funds were approved on March 3 for
these
trials).
In addition to this compound, there are
many others that war~
have been examined by the University of
Michigan for antagonist potency, and these data are 'hidden' in the
archives of the NRC/NAB. At the request of various agencies, Dr. Vil~
lareal nas agreed (February, 1972) to undertake a review of the data;
and should other compounds be identified, these should be assayed in
man, with particular emphasis on their 'purity', degree of antagonism,
and duration.
rant study.
Many compounds
'
Under the
have returned to
compounds. This
Sterling
stimulation of Congress, various industrial concerns
their laboratories and examined their files for active
is true for Merck (levellorphan), Bristol (BC 2605),
Winthrop (fi-cyclazocine), and Geigy (GPA 2163)
drugs warrant more intensive examinations.
--
and these
�March 10, 1972
Dr. Daniel X. Freedman
Finally, perhaps an interested scientistwith experience in
analgesics, could be encouraged to visit various laboratories to dis—
cuss on an individual basis, the availability of compounds or congeners
in their files. When this was recently done with Janssen in Belgium,
we were able to identify two possible compounds of interest, and to
stimulate their further study.
3) Biochemttal synthesis methods. The basic chemicals from
which these antagonists are derived are in short supply, apparently
because their manufacture is derived from thebaine, a proscribed commodity. Some effort should be made for chemists and botanists to iden—
tify other manufacturing methods and other sources of the raw materials.
In this review, I have neglected the need for training psychi-
atrists and clinical pharmacologists in the special problems of studies
in addicted persons (patients usually have a different agenda than the
scientist); the need for studies of the extinction of learned patterns;
and the need for the studies of the dependence process itself. These
general issues are of special concern to the committees of the National
Institute of Hental Health, and will surely occupy the attention of
the new proposed centers.
In our discussions of the
ways
in which these studies could
attract the attention of scientists in universities and industry, one
suggestion may be of Special interest. Should an agency, preferably
non~governmental, outline the needs for a long acting antagonist, de—
fine a reasonable deadline, and offer a prize of significance, would
this not stimulate those men who may be unable to visualize the needs
of the formulation, to attempt its development? Should an agency offer
$50,000 or $100,000 for the development of a narcotic antagonist, with
a duration of a single administration of 60 days, sufficient to block~
ade diacetylmorpnine 25 mg/2 cc/2 minutes, in man «s would this not
stimulate some interest? (An example is the announcement of the Anna
fionika Foundation prize).
Two additional needs: support for academic scientists to work
directly with industry on a 3»6 month 'fellowship' basis; and support
for regular meetings of investigators interested in the narcotic antago
onists, similar to the annual methadone meetings. (When we suggested
the methadone meetings set aside time for the antagonist workers in
York and in San Francisco, our suggestion was denied. The only
special meeting was sponsored by NINE and the New York Medical College
on June 4, 1970).
Nan
�{I
Dr. Daniel X. Freedman
March 10, 1972
These are some random notes. Should you be interested in the'
will provide what I have. Meanwhile, my latest summary
as prepared for Contemponaty Dnug Pnobfieme is enclosed.
'back—up', I
Again,
my
thanks for lending ye your ears.
My
best regards.
Sincerely yours,
Max
Fink,
M.D.
Professor of Psychiatry
HF:ig
Eflnc;
�
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mfp-05-00-026-1-052
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1972
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e265641dc6948b6b6d5f682b3cdf2c34
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February 11, 1972
Dr. Robert Petersen
Division of Narcotic Drug Abuse
National Institute of Mental Health
5600 Fishers Lane
hockvi lle , .i'aryl and
20 852
near Bob:
Enclosed are the two revised budgets, for the Jamaica
and Greek study programs.
Separately we will send the detailed progress report and
protocol for the Greek study, probably within the next 10~15 days.
For the Jamaica study, we are unable to relate our proposal
we will accommodate
to the prior study without your help. With
it,
the social aSpects to the data of the prior study.
Many
thanks for yourttime.
Sincerely yours,
MEX
Fink ,
2‘. D a
Professor of Psychiatry
HF:ig
Eflc.
�
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mfp-05-00-026-1-055
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1972
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February 8, 1972
Miss Risa Dickstein
Vera Institute of Justice
30 East 39th Street
New York, New York
Dear Risa:
I read of your presentation to a legistative commission
on Friday, and realized that the heroin program has been well
formulated. If a copy of the proposal is freely available, my
associates and I would like to read it.
Good
luck, and
many
thanks.
Sincerely yours,
i‘lax
Fink ,
1‘1
0
D
0
Professor of Psychiatry
Ming
�
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mfp-05-00-026-1-056
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1972
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hwy—raw
,
W;vw—.m-r....,—.
-~—-.
”firm
.
m
m
March 6, 1972
Mrs. Elaine Gasasso
Executive Secretary
American Society for Clinical
Pharmacology 6 Therapeutics
Houston Oaks Hotel
Houston, Texas
Dear Mrs. Galasso:
Please extend my regrets to Chris
for I will
be unable to addend the Scientific Awards Zarafonetis,
Committee meeting on
March 8, in Houston.
Thank you.
Sincerely yours,
Max
Fink,
M.D.
Professor of Psychiatry
MF:1g
�
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mfp-05-00-026-1-057
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1972
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5f9d3d16560fb958b3a468570da1950a
PDF Text
Text
March 6, 1972
Dr. Joe P. Tupfino
Professor
Enivoroity of California
Division of Mental Health
Dopartmont of Psychiatry
bovis, California 95616
Bear Joe:
In thinking about your wish for a young psychiatrist, thorn
staff, Jan Volavka, and Richard Abrams who have
good backgrounds and are interested in leaving New York for annular
cllmes. Their curriculum vitaeo are attachod.
are
two men on my
Volavka is a fine eloctroencephalographer, good statisticion,
and a methodical and industrious worker. Be is new to the grants
systeaa, and has been sponsored by me. so has no active grant. pro~
grams. a. is the principal scientist in my heroin study 33—19476.
filo publication list is extensive. and his work is of high quality.
so that I on confident he will be able to establish a program.
Abramo
my SGT
is younger.
study program.
Mfl~15561. and
evaluations.
He
t
clinician
who aas worked
is the printlpnl worker of
in charge of the
payohoPharmacology
I on willing to "roloasu” those
hero but aro Instive because of
Good
How
men
actively
my BC?
clinic's
luck.
Sincerely yours,
Fink, H.D.
Proton-or o! Psychlttry
first;
too.
grant
new
drug
since they haw! grown
York's many haxolea.
3::
on
�
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http://exhibits.library.stonybrook.edu/mfp/files/original/11e50f7b08848b335f64dacec70c9426.pdf
a79b39b147bd5b0afe865144f9faa743
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WEE
‘
mum—w
March 1, 1972
Dr. Arthur W. Increiter
March Sharp 6 Donna Rascarch LaboratorieWest Point, Pennsylvania 19486
Dear Dr.
Iacroltcr:
The supply of levomethadyl arrived safely w many thanks.
augment our studies by incraaaing the
nunbcr of subjects and the time. Our report is now in galley
for the JANA, and should Appear shortly.
We
will use this supply to
My
best regards.
Sincerely yours,
2h! Fink, Moi):
Professor of Psychiatry
mrzig
cc; Clyda Strickland, 3.0.
�
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mfp-05-00-026-1-060
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/98b8d3a81e4abb29aab4e27257f50488.pdf
18552a6c7c909973fca981d54bd5fae9
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February 28, 1972
Dr. Allan P. Berger:
Associate Director
Pfiur Inc.
Eastern Point Road
Grown, Connecticut 06340
RE:
Lithane
ERR 2/13/72
Dear Alan:
are most grateful for the supplica of Lithane (lithium
carbonate) which you so kindly made available to us in 1970. Silica
that time we have trested more than 20 patients, neatly those unifaring from mania, and the supplies are exhausted.
Re
Early in 1971, Lithane was approved by the fomulary courmlttee of fietmpolitm Knapital Medical Center for psychiatric uses,
and is no longer "investigationnl" and not under out control.
Thank you
for your assistance.
fly
best regards.
Sincerely yours ,
Fink, Md).
Professor of Psychiatry
has:
�
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mfp-05-00-026-1-061
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/290c897a5ee3ec44ca54bfc0aea53543.pdf
d7b83b5ef7d2bdf95819b890e5b0409b
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Februnry 28, 1972
Stanley Einstein, Ph.D.
Executive Director
Institute for the Study of
680 West End Avenue
Raw York, New York 10025
Drug
Addiction
’
Bear Stan:
Th: potential importance of the narcotic antagonists in
both the trcatmant and prophylaxis of opiate use should mako a pra~
scntttion of the availablc data a muttcr of high priority. While
I do not believn the College will bu able to find the travel coat.
for the misting, I could suggest you list my presentation and be~
tween us, we should be abla to find some solution. If not. the were
listing will, at lcast, give the possibilities some visibility. and
enhance the historical record of the meeting.
As a title: "Antagonists in the Prophylaxis and Treatnnnt
of Opiate Dopandenco".
Goodlluck.
Sinceroly yours,
flax Fink, H.D.
Professor of Psychiatry
HF:ig
�
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1972
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a57be03c04d724ed5f7030458850d573
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~“K‘
“-‘mw‘vflrw-‘m'"' mm run: n“
"Km 7
‘
»-
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,_, Ht... “Hrs," w”,
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.
1...
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.Y,
‘_
March 33, 1972
Julian It. Laoky,
fiational Institute of'obntal Boalth
PEAK}.
flockville,
234m land
Eef: mom
M23158~01
Dear Jack,
While the propocal, "Treatment of'Schiaophrenia by
important and interesting goals, the methods are
EU?" has
Regressive
inadequate to
it
tile?
wish. to encourage such
tho invoctigatom to discuss
task. Shoula tho Comrlttoo
for
a program,
'tao loouoo with others: tho lntorrolationo of’modiflcations of‘tfie
EC? process to thorapoutlc outcome, and the ioauos in quantifloatlon
of the EEG. In addition, since the twin leouoo in rogrosoivo 3326‘? from
a publéo health point of'olow are the long torn offocto of‘multlple
ooizuroe, coon as an assault on the oontral nervous syctong particularly
on matures of brain function and on ouch capacities as concorztmt’lon,
momory, and thought processes, the evaluation of‘nourological doflcéts
and paychologicol tosto fbouoaod ow what to usually called 'organiolty’
must be conoldored.
would be adviecdalo
The investigators have done an
of'rcgrocoioe EC? in schizophrenic patients.
interesting clinical study
There to a mood for such
a ro~ovaluatlon of’rogroaaivo fill; for thin modification has a chequered
rarely useful. Recent otudloa of’multlple
history. Oldor studies found
Elf; undor omygonatlon control, have indicatod that multiple ECT ans
it
dofloito, or EEG
soft, producing no moro momory loss, neurological ECT
only occasionally
changes than single ECT. Unfortunately, multiple
produces bettor results than single EST in doproeood patients. The data
for schizophrenic patients is unclear, holevor; and thorn now are some
roports of'bottar results with multiple ECT. Those data require vorifloation, and in this framowork, the proposal by Ewnar warrants some
aselstanoo.1h its prooont form, it is inodbquate to the tasks outlined
by the investigators, and suggested by my view of the public health ioauoa.
5%:
favorable foaturos of the proposal:
1) the population is adequate, and the setting to probably a good one for
such studies. (1h our investigations of ECT at Gracia Square and Hillside,
was in those small hospitals that tho staff’wore favorably diaposod tp
it
Elf; allowing tho inventigationa to proceed.)
2)
Tfio
investigatora
have an
interact and
coma
experience in regressive
ECT.
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. .w-r—
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”g:-
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W\Jr‘v4r-'wv-n.wl Jaw.
EXNERO'IIOOOOOUOIOOOOOIOIOOOOOOI. EICOIOOIOOOOOODO
3) The PI
..
.
.n,
.
‘n'mgrflwrr
:IWBst"-v~l*’!‘-vm
March 23’ 1972
sahibits statistical and design sophistication, and his
rocord as psychometrist
../.,._~
~....-_».-r.~n.
is
good.
"7”,
The
negative features of the proposal:
1) The design is EDT vs. drug treatment. Ihie
the design to be followed,
issue, but were
it
is not the
most important
there are specific problems.
While the evaluation methods may be adequate indices of
2)
change in personality and behavior, the issue in gegressive ECT is the
impact on interpersonal behavior, neurological deficits, thought
processes, memory, and concentration. In their first study, they
emphasise a persistence of’some of the thought disorder—- but is
and how is
changed ? The clinical aspects seem inadsquately
it different
covered, and the emphasis on a psychiatric interview no less than 30
minutes and no more than 45 minutes is mechanistic and less than helpful.
it
,
ihe EEG evaluation is at thewwrong time for any important
issue. Perhaps the EEG should be evaluated soriatim (weekly) to assess
the rate and degree of change in brain function. But most critical
is the likelihood that the patients will all receive drugs after the
treatment course. The druggcontrols of‘neeeseity; the EC? patients
most probably. Since no statement is Mada about the specific drugs,
dosages, and relation of.EEG measures to drug intake, I have to assume
the investigators are not acutely aware of the impact of drugs on the
536. To unravel EEG effects of BCT from drugs without attention to
the controls necessary, is exceedingly dijyicult.
Zhe same problem in the evaluation and followvup will
occur for other indicss»~ what is the impact of'drugs given after
regressive EC? on the EC? process, and on the comparison of ECT and
drugs ? (For this reason, I would favor regressive ECT vs single ECT).
3)
Patient selection is an issue. The statement of'proceee
schizophrenia is inadequate. The tests described are too non~specific
to help others define the population. It were better for the investigators
to specify which criteria of'process schizophrenia they use (3.9. Fish,
fluylor, others ?). Psychological tests are supplementary~~ they cannot
be used as the diagnostic criteria.
criteria
While
I
am
not ordinarity prone to question selection
ethical grounds, in this instance, the authors should be
asked to make clear some of their minimum criteria of'prior treatmonts
and failure, recent treatmont and failure, etc. before regressive ECT.
Should not all patients have had a course of 'regular' ECT and failed ?
4)
Psychological tests are given heavy emphasis, but the
theoretic base from which these tests more selected is not indicated.
Why the MMPI and the SPEC ? Neither is sufficiently specific in its
interpretation to be very helpful.
on
.
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raw-m
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wuvvmuw-mgw..~-mw '3.“ “y“ we
.-4"p~)'I-‘l
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OIOOOOOOOOODOCIIOOOOWI!
.»
—.- .
~
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PM
....~
23’ 1972
There are many problems with the EEG measures, but since
I)
the study could be done without EEG measures, I will not go into full
detail of’theinadequacies. It is not clear why the investigators are
measuring EEG effects, for the only specific suggestion comes from the
description of lack of’abnormality before and after treatment, as
evaluated by the neurologists on visual inspection. Ihe issues
that could be investigated are the differences in EEG effects of
regressive ECT vs other Elflk the rate at which the induced changes
disappear; the relation of change to improvement, to memory ef?ects,
or to other neurological indicee.
They suggest quantification of'the EEG; suggesting
recording and analysis for short epochs. The equipment they
request, representing a large part of'the budget, is adequate only for
the analog to digital convereion, and some simple steps of'data reduction.
But EEG data ie voluminous, even when reduced, and the interrelations
among many channels a horrendous task. (Indeed, very few investigators
have challenged more than one or 2 channel data, and if'more, only for
1 0r 2 minute epoche).
3 channel
To
is
Their interest in sleep
EEG
is unjustified in the protocol.
eben suggest cloep EEG recording (3 hours), for 8 channels (1),
so voluminous a tack, tiat I suspect they do not mean this. gheir
suggestion about.doing visual analysis of the sleep records is
interesting, but thie too it a big tack, and will not in their
few cases, answer any of the auctions. She came problem of drug
control must be considered here.
#-
10
d
J!
.Ez.reureading this proposal, I believe the investigator
brings to the questions, posed by his clinical colleagues, and experience
as a clinical psychologist and psychometrician. fhese aspects seem well
handled. For 'eeientific' reasons and interests, they are suggesting
EEG analyses, sleep recording, and some follow~up studies. In these
aspects, they seem to lack experience, but also sufficient judgment to
visualize the taske and to obtain advice. Perhaps, were they encouraged
to visit and'worh ith one of the university based centers studying
ECT and one focussed on quantification of the EEG, these issues might
become clearer to them. were they then still interested in the studies
suggested here, a better proposal might (?) be forthcoming.
Alternatively, the design could be reduced to a clinical
replication of their pilot study, with some better statement of'the
population, assessment of’neurologioal effects, control of EC? parameters
and drugs, etc.—- and a contribution made to the EC? literature. In the
latter case, the budget could be subjected to reworking, deleting
sleep and statistical consultants ($3800), equipment ($20,500), and
EEG chart paper ($600); with additions for neurological evaluation.
helpful. Iou already know the
I trust those comments are
these
laboratories
in
interested
issues, and I am confident
principal
that any would be interested in this study.
’ISincerely yours,
Mam
Fink, M.D.
.
u--- .
.7
.,.r
,.
.
_.
�
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mfp-05-00-026-1-064
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/3309cdce29e7d39375703d9a6c1c7cfe.pdf
58330d19c929b9fbafcef7a742bbb8b4
PDF Text
Text
February 22, 1972
Norman
Pitts,
M.D.
Pfizer Pharmaceuticals
Groton, Connecticut
Dear Norman,
time ago, Garden and Cole asked us to
Some
assist
them
in the analysis of their date of a chronic high and low dose thiothixene
study. They supplied the tapes, we did the analyses. There were some
problems in the data collection, related chiefly to the copperation
of the patients and our inability to train the staff adequately. Hevcrtheleaa,
the analyses do demonstrate consistent EEG effects, similar for the high
dose thiothixene as
summary
I
we
am
found some time ago.
taking the Opportunity to send you a copy of the
report, for your information.
My best regards.
Sincerely yours,
Fink, M;D.
Professor of Psychiatry
Max
�
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mfp-05-00-026-1-065
Date
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/c2a01aa26d189a0fa450f59a64183996.pdf
f659f6168942af18c3b65d30be5409fa
PDF Text
Text
February 22, 1972
Dr. E. Garden
Boston State Hospital
Boston, Maaaachusetts
Dear Dr. Gardos,
Enclosed is thc summary report 0! the EEG data analyses
of the high and low dose thlothixcnc studies completed recently. while there
technical difficulties, there was sufficient material to elicit
drug~EEG effects in the lang~tcrm treatment condition. Thu ahort~tcrm
cffccta were less clear, probably as a result of the small sample.
The decrease in mean frequency and in mean frequency
is consistent
variability measures with chronic thiothixcne administration
the
and
with
of
thiothlxcne,
thc
effects
of
ctudica
with our earlier
Pharmacol.
CAnn.
Rev.
earlier
publications
classification proposed in our
were some
9:2blv258, 1969).
h
I trust these data are
information, please call.
Hy
artful.
Should you wish any
further
best regards.
Sincerely yours,
Max
Fink, M.D.
Profcsaor of Psychiatry
cc:
J. 0.
Cole
�
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Title
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Correspondence to: Gardos, E
Type
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Text
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mfp-05-00-026-1-066
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/716c03cbb3716785ed619022a248e1a5.pdf
c536ac462ec53e2fc9e50693a4e42ed6
PDF Text
Text
,
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,.
February 22, 1972
Samuel C. Kain, M.D.
Director, Alcohol
&
Drug Dependence Service
Veterans Administration
Washington, D.C. 20420
Dear Sam,
.m
pawl-"Wu”...‘mu,’
I look forward to participating in the 17th annual V.A.
Conference in St. Louis next month. At the and of the week, I will have the
time to write a summary of my presentation on tho panel, and should send
it to you next nook, well in time for the session.
A.nhort c.v. is enclosed.
For the teaching session, I will prepare a summary of our
present treatmont approaches, onphacizing the similarities and the
differenceosin using mnthadono and lnvoncthadyl, and cyclazocino and n31—
crane; and the relation of thosn drug rcgimona to rohabilitation, caaawork,
re»education, counselling, and psychopherapy.
It was kind of you to consider my serving on the steering
committee for the collnborative studios in drug abuse, particularly for
acetylmcthadol. I would be pleased to contribute whatever I can. and have
that my experience may be of assistance. (My paper on l~alpha~acotylmethado1
will appear soon in the J.A.M.A.~— they changed the name of the drug to
the
new
generic
'official' titlo of
My
LEVUNETHADIL.)
best regards.
Sincerely yours,
Max
Fink, 3.9.
Professor of Psychiatry
�
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Title
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Correspondence to: Kaim, Samuel C.
Type
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Text
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mfp-05-00-026-1-067
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/aefafe983fdf3b55e0aada9ae1016801.pdf
3882baf5196b37369a7641eeeadeb5ad
PDF Text
Text
February 22, 1972
M133
Roberta London
Monoging Editor
Contemporary Drug Problems
515 Oxford Street
Heatbury, flew York 11590
Dear H139 London:
v'-
made, the biography submitted, and the
I nave added the latest data to the text, and the
title shortened.
N133 and the White fiance
report should be most timely, for the USPHSon- the
antagonists, which
SAODAP are both preparing larger programs
should be announced shortly.
The
own—mop."
“h...
.w
awn..-”
—
v
~—~w-w
corrections are
additional chores, should you docide to prepare a cannabis issue, our studies of the acute and chronic
effects, both in New York and in Athens, are most interesting.
While I am not looking for
I look torwcrd to seeing your
anwwuuy—mv—
first issue.
Good
luck!
Sincerely yours,
,
A
—».
an: Fink, M.D.
Protector of Psychiatry
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�Dr. Max Fink is Professor of Psychiatry and Director of the
Division of Biological Paychiatry of the New York Medical College
in New York City. Since 1966, on has extensively studied the neuro—
physiologic and clinical effecte of narcotic substitutea and antagonieta in opiate dependence. and the effects of chronic cannabis use,
both in the United States and overseas.
He is a graduate of the Rev York University College of Mad~
icine (1945); is certified in neurology (1952) and paychiatry (1954)
the American Boards of Psychiatry and Neurology; and in paycheanalyaia (1953) by the William Alanaon White Institute (New York).
In a research career begun in 1954. he has been Director of Raaearch
at Hillside Hospital (New York) (195A-l962), and Director of the
Missouri Institute of Psychiatry, and Raeearch Professor at Washington University (St. Louis) (1962-1966).
by
Hie principal studies are in the neurOphysiologic (electro—
encephalographic) and clinical effects of psychoactive drugs and
coneeileie therapy. Applying computer methods to these analyaea.
he has provided theoretic models of the relation of EEG changes and
behavior in man, and of the node of action of convulsive therapy.
He
has
just edited a special issue of
Seminanb
in Pbychiazay devoted
to convulsive therapy, and will chair an international symposium on
this subject in collaboration with the Rational Institute of Mental
Healtu in 1972.
Institute of Mental
Administration, the Columbia Broadcasting
Syetem, and numerous industrial concerns. He is the Executive Di—
rector of the International Association for Psychiatric Research,
Inc. He is married, father of three, and is a resident of Great Neck.
He
Health, the
Long
has been a consultant to the National
Island.
Food and flrug
�
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Title
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Correspondence to: London, Roberta
Type
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Text
Identifier
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mfp-05-00-026-1-068
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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The Max Fink Collection
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Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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application/pdf
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/704f08814452eb025f72d6988e4a2d03.pdf
75cdb6dc0fa33eb829efdfe0a39131bb
PDF Text
Text
February 22, 1972
Dear Dr. Plstcow,
It is quite
I have read the section
good, and
my
on
few comments are
antidepressants carefully.
listed in the margins.
I would suggest that the sections related to the presumed
effectiveness of the MAUI be reviewed, for the available data is chiefly
uncontrolled testimonials. The list of dangers is well documented, however,
and the contrast sufficiently great for us to have eschewed the use of these
drugs in our treatment programs. Indeed, the risks are as great as with the
amphetamines, and perhaps the same cautionary tones should be encouraged.
Recent evaluations of convulsive therapy, particularly
with the modification of unilateral ECT, with succinylcholine and
Brevitsl, show this technique to be 80~9OZ effective (and safe) in severe
depressive states. Perhaps the Council should review the whole range of
therapies listed under 'antidepresssnts', and introduce a section on ECT.
This treatment is surely more effective and safer than the amphetamines
or MAUI. For a recent comprehensive review, see the February issue of
'Safiffiafg {M organtatfiy; published by Grune & Strstton.
these notes
may
Finally,
may
give in the
I ask that
list
you acknowledge the
of acknowledgements
? Many
little
thanks.
help
Sincerely yours,
Fink, H.D.
Professor of Psychiatry
Mex
�
Dublin Core
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Title
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Correspondence to: Platcow, ?
Type
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Text
Identifier
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mfp-05-00-026-1-069
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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The Max Fink Collection
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/7618f4be2d528d7de71757a2c8b8c02e.pdf
48c3daf55f464a26d444d4e0cf62fc72
PDF Text
Text
n‘w‘
Va.
r-
-
vm
uw
4v
m
«wu—
--
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W “fl-WW"
1-:
v.
,
rdm'wv'nvv"mwl'melwvva—H."IMF—VJ «.wi van
:-
Fabruary 22, 1972
Binaa, Ph.D.
Director of Biological Research
Hoffmann—La Roche, Inc.
Nutley, flew Jersey 07110
Mr. L. R.
Dear Len:
I hava read the data ahaata on Lorfan and RD 6-6711 with
interest. fiocuaaing on thair possible uaa in opiate dapandanca.
The data on Ro 4~67ll ahows this to be similar to cyclazocine in structure, with similar side—effects on low oral dosage
(0.5 mg) - sleepy, uncomfortable thoughts, “drunk",bhtt with
vomiting also. Thasa effects reflect a nigh dagraa of agoniatic
effects, canaidarably reducing our intaraat.
data on Lorfan is more promising. It is a well defined
antagonist, and a program dcaignad to extand its duration of action
may be useful. It may be important, howavar, to clarify the commant
in the packaga insert, regarding enhanced respiratory dapraasion
with repeated doaaa. If varifiad, this will be a deterrant to further davolopaant.
The
Thanka
for the opportunity to raviaw these data.
Sincerely yours,
Fink, fi.D.
Professor of Psychiatry
Max
�
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Title
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Correspondence to: Hines, L.R.
Type
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Text
Identifier
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mfp-05-00-026-1-071
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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The Max Fink Collection
Description
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Rights
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<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
Format
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application/pdf
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/c17852605a5a75e1c0608a89f937c258.pdf
68935274afd0500a2e70ba9eb4e80ad2
PDF Text
Text
February 11, 1972
Dr. Robert Petersen
Division of Narcotic Drug Abuse
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear Bob:
Enclosed are the two revised budgets, for the Jamaica
and Greek study prOgrams.
Separately we will send the detailed progress report and
protocol for the Greek study, probably within the next 10-15 days.
For the Jamaica study, we are unable to relate our proposal
to the prior study without your help. With it, we will accommodate
the social aspects to the data of the prior study.
Many
thanks for yourttime.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
Ming
Bic.
�
Dublin Core
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Correspondence to: Petersen, Robert
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mfp-05-00-026-1-072
Date
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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The Max Fink Collection
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Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/ad859a64a62f0fecfd1b052cbbab1f9a.pdf
0818d85f64d880d64daa42393f73f34d
PDF Text
Text
February 8, 1972
Prof.
Hebrew
Israel
R. Mechoulam
University of Jerusalem
Dear Prof. Mechoulam,
<7
:-
Mammy-”WV
I have just returned from examining some of the chronic
hashish users in the laboratory of Prof. Miras in Athens. We observed
4 men as they smoked various doses of hashish, U.S. grown marijuana,
THC impregnated placebo marijuana, and placebo marijuana. Our data
is confusing, for the men exhibited 'tolerance' to hashish, but not
to marijuana; they showed behavioral changes to marijuana which seemed
distinguishable from their responses to hashish; and they showed
no reaponse to 75 mg THC.
One
<v:
is the different
of the
mix of
possibilities underlying these
constituents in the
mixed observations
two samples. Before
leaving
Athens, Prof. Miras provided us with another sample of hashish which
has a low concentration of THC, and the men reported this sample to be
'without
effect'.
are replicating these observations in another sample;
THC~A~9 and ~8. I have some
samples of the two types of hashish, and the U.S. marijuana, and I am
writing to ask if you would be willing to assay these for us. There
is some question in our minds as to the actual concentration of the
presumed active substances. May I send 4-6 samples to you ?
and
We
will undertake additional trials with
Many
thanks.
O
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
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"“7
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Dublin Core
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Title
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Correspondence to: Mechoulam, R.
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mfp-05-00-026-1-073
Date
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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The Max Fink Collection
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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application/pdf
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/5340baf965e13146034b7c538e17eeb7.pdf
91485f31d4e7d56016289f4fef337d15
PDF Text
Text
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v.—-‘—vm-um‘,pv_..m -:‘n‘.w m
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February 8, 1972
Max
Gordon, Ph.D.
Bristol Laboratories
Syracuse,
New
York
Dear Max,
a follow-up on the inquiry on Clumacran, I asked
the
to review the notas in their files, and I received the
enclosed extensive print~out. This may be 01 interest.
As
flIMH-PRB
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
w—uvv—mn
»
v
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�
Dublin Core
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Title
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Dublin Core
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Title
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Correspondence to: Gordon, Max
Type
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Text
Identifier
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mfp-05-00-026-1-074
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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The Max Fink Collection
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Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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en-US
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application/pdf
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/e290f0d9323e2ce6dcfd7ef57c73e863.pdf
52e649cb61d9d8abb2250b788a67a6b3
PDF Text
Text
".7
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February 8, 1972
David Davis
PRB—NIMH
Rockville, Maryland
Dear Mr. David,
Thank you for the print—out of the ECDEU summaries on
clomacran. These were indeed very helpful in my decision not to
undertake an EEG study of this dnug at this time.
There are two other searches which are of immediate
preparing a report of the EEG profile studies of
and
doxepin,
clinical evaluations of the compound in depressive
and
in
anxiety states, would be of interest as background for
states,
interest. I
am
the evaluation of this profile.
(Ortho) and
am contemplating EEG studies of ORF 8063
(Pharma Research Canada). Are there any
of these drugs underway in the ECDEU system ?
Secondly, I
PR—F~36—CL
clinical studies
Many
thanks, again, for the data on clomacran.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
Ay’
,
mm...“
4
:zowang-ya
inf-A,
‘—
�
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mfp-05-00-026-1-075
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/2f94f9fcff65a55b8d6cce8acc19cf74.pdf
e50dda93588cade17e2a2ed9bab810ed
PDF Text
Text
“W...”
We.
,~
w ” at“ m
r.
,
V
V
.
.
V
,
‘
y
,
vane—ow 3'53!“va ~_-.mwrs+ ~ A.»
V
,
,
7
-wwwwwmwiwj
i
i
February 8, 1972
Ms. Judith Kiolbassa
Copy Editing Supervisor
AMA
Chicago,
Illinois
Dear Miss Kiolbassa,
Enclosed is the typescript copy of article 0658 for
the Archives general Psychiatry, and my notes on the text. The
handwritten notes are sufficiently clear, and refer to the text
pages. Please add the additional reference.
Thank you
for your assistance.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
.
-
,
"""-“““ W “F ““'“""' V -
�
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mfp-05-00-026-1-076
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1972
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/1855f38cb5e197a5c00b704d72bfc428.pdf
05e88be5bd3923d1d2bb801ef07ed67f
PDF Text
Text
.
February 8, 1972
Paul H. Blachly
Professor of Psychiatry
University of Oregon Medical School
Mr.
3181 S.W. Sam Jackson Park Road
Oregon 97201
Portland,
Dear Paul:
Your letter regarding Congressman Pepper's bill is interestI do not know the bill in question, and can only comment on
your questions.
ing.
In general, in our study of the narcotic antagonists, I have
found the FDA verbally c00perative. Their dependence on rigorous
and extensive animal toxicology data has prevented human trials of
M5050 for 2 years, since we have been unable to find $30,000 to pro—
vide this data. The same attitudes have caused delays in studies
of BC~2605, and added immeasurable costs to studies of naloxone.
to your suggestions, I believe these are useful and may
- who discussed some
proposed changes in his section of the FDA at the recent ACNP meetings.
As
be in the process of adaption by Elmer Gardner
I would not encourage another committee. The present NINEcommittee reviewing protocols for drugs is sufficiently restrictive and limiting in its views (E;E° of cannabis) to provide a lifetime of delays and excuses to stifle research another could do
FDA
little
—
good.
I
not encouraged to attempt redress by the Congressional
or committee routes both are fora for selfish ”politics" interests
and not effective roads to research. The latter can only come from
the scientists assuming the burdens of research and challenging the
variOus agencies' on a case by case basis. Perhaps it is in the
education of our colleagues (345., the limitation of unsophisticated
dependence on animal trials) that our hopes and opportunities lie.
am
—
Sincerely yours,
Max
MF:ig
Fink,
MA).
Professor of Psychiatry
�
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mfp-05-00-026-1-077
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1972
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/6b9087c92b07a6686557b410d6ce0236.pdf
9f3dc8cbdf658c84038e144f16744c04
PDF Text
Text
.\
u.“ WY s—vmw-m
February 8, 1972
Miss Risa Dickstain
Vcra Instituts of Justice
30 East 39th
New
York,
Strsot
Now
York
Dear Risa:
I road of your prcsontation to a lcgistativo commission
raaliasd that tho heroin program has been well
formulatsd. If a copy of the proposal is frooly available, my
on Friday. and
associatcl
and
Good
I
would
luck. and
like to road
many
it.
thanks.
Sincarely yours,
Max
Fink, H.D.
Professor of Psychiatry
MF:ig
�
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mfp-05-00-026-1-079
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/9674ba447ca2e4c35ac259616d9075d5.pdf
9c4f2e3a56251f62d1851bb94a2e8c94
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-Ww
February 8, 1972
Dr. Arthur W. Tacroitor,
Merck Sharp £- Donna
3.0.
Division of Harck & Colpany, Inc;
Heat Point, Pcnnnylvania 19686
Dear Dr.
Tacroitor:
for making additional ouppliao of tralpha-acetylmethadol available for our studies. I an ancloaing the appropriate
3ND 222C form and a xerox of the schedule I permit PF0024555.
Thank you
I trust our ongoing studies will continue to support the
usefullssa of this compound.
Sincerely yours,
flax Fink, M.D.
Professor of Psychiatry
fiF:ig
Enc.
.
�
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mfp-05-00-026-1-080
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/3d71130cdce7bd94ecbaa66190dffc66.pdf
648630ed41e61677d90808c184a939de
PDF Text
Text
February 8, 1972
Dr. Turan M. 1:11
Professor a Asaociate Chairman
Chief, Section of Clinical Neurophysiology
&
Psychopharmacology
University of Missouri
5400 Arsenal Street
St. Louie, Miaaouri
—
Columbia
63139
Dear Turan:
Congratulations. on your energy and enthusiasm to edit a
and drugs. It would be a pleasure to participate, and
I will try to provide the two articlea you requested.
book on
CNS
our
new
EEG
"EEG Profiles to Identify New Psychoactive Drugs and Measure
Bioavailability" by Fink and Shapiro will privide a aunnary of
classification scheme, and our recent 4 years of experience
drugs and conpariaona of drugs of different fornulationa.
will
I will be glad to work with Volavka to prepare a summary
Effects of Druga of Dependence and Abuse". describing the
similarities and differences among alcohol, opiates, amphetamines
and LSD, etc.
on
“CNS
In your
list
of proposed models. I aieaed a presentation
by Don, and note the tapic XII ~ Statistical Techniques. while I
aeaune you will ask Mucciardi, perhaps you would reconsider. Muc~
ciardi'e experience in limited and his recent report to you primitive.
Don and his aaaociate Marvin Glaaaer have examined acne of our data
by many etatiaticel techniques. Our data is extensive and an invi~
tation will provide an incentive for then to present their experience.
�away—w
mnw~
u
-
Dr. Turan
I
M.
Finally,
do not know
Fun,
fun.
Itil
who
.
February 8, 1972
aro Caillo, Danbcrg, Horowitz, and Robinson?
thoir work. Should I?
tho 3 F's, I havo addad a fourth - Flying; nnd Family,
Financial arc vary unaful guidelines. The chapter: will be
To
My
later this
but to Ellan,
month.
and
I look forward to using your family
Sincerely yours,
flax Fink. M.D.
Profasaor of Psychiatry
�
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mfp-05-00-026-1-081
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1972
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/98f0966a463e9ca6f84ed01ae60b6710.pdf
5585527392b77d9f9a30e21d0f1e48bc
PDF Text
Text
,,
...
.
w...“
‘qu.an
1-. ‘
.vmmmmtwmmawwanmw—uw
February 7, 1972
Dr. Leo E.
Holliater
Hedical Investigator
Veterans Administration Hospital
3801 Junipero Serra Blvd.
Palo Alto, California 94304
-/v-A
ur—wv-W—w—u—w‘
Dear Lao:
studies of cannabis are proceeding in chronic and
acute trials in volunteers in New York and in studies of long term
hashish users in Greece.
Our
The flew York
studies are focused
on the behavioral. memory,
and SEC effects of different doses of sacked marijuana, both in
single dose studies and 21-day chronic studies. The data define
the central EEG effects, bear direct dose relationships, and show
some evidence of tolerance development. These data could be pre—
sented as "EEG and Behavioral Effects of Marijuana", by Pink, M.,
Volavka, J. and Dornbush, R.
we have examined 35
we are now comparing
In Greece
subjects
who have used neon-
the effects of seeking hash~
years,
THC~8-9,
and ganja (Jamaica) on beish (Greek), marijuana. (U.8.),
havior, EEG, heart rate, and performance tasks. These data could
be presented by Dre. C. Stefanie or C. Miras - "Long Term Effects
of Hashish Use" by C. Stefania, C. iiiraa, R. Dorcbuah, J. Volsvka,
ish for
and
M.
+25
Fink.
Sincerely yours,
Max
Fink,
M.D.
Professor of Psychiatry
�
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mfp-05-00-026-1-082
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1972
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/ebce77ae7d7ef5f1ad6a462f73657f35.pdf
6d0316b8b470505531a23b19fbe28434
PDF Text
Text
February 7, 1972
Dr. Stanley Muhler
Office of Aviation Medicine
AHrlOO
Federal Aviation Administration
mmmgm,mm
Dear Dr. Muhler:
City, invited the participation of our laboratory in a conference on cannabis in Oklahoma
in June. When the invitation was discussed, we realized that a
flight simulation task would be a most sensitive index of central
nervous system effects. Indeed, the sensitivity of the driving
sienlation has been demonstrated, and the additional planes of
Dr. James Lewis, FAA. Oklahoma
'Im—v
-
reference of the flight simulator should exaggerate the sensitivity
greatly.
Are
,wvw.v.w‘m
consideration?
studies of cannabis on this task in progress, or under
If not. would such studies be of interest?
w,
are involved in a variety of studies of cannabis in
volunteers in the United States, and in chronic hashish users in
Greece and Jeeaeca, West Indies. My personal interest is based on
my recent licensing as a pilot, BEL.
we
Thank you
for your reply.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max
w-
W's-v"
“rm-ewe-
'
m’oW‘W
www-
wwwx-
MF:ig
�
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mfp-05-00-026-1-083
Date
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1972
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/a39c7b4352f46afb6f7d6fbb8c6507ce.pdf
2361af3732aa3d8149560382eef2dee5
PDF Text
Text
February 7, 1972
Dr. Avram Goldstein
Department of Pharmacology
Stanford University Medical Center
Stanlord, California 94305
Dear Avram:
reports to the Methadone Conference were progress
reports, as participants in a symposium. The basic data is in
press, the cyclazocine in Comprehensive Psychiatry (1971), naloxone
in JAMA (1971), and the iralpha—acetylmethadol in JAMA (in press,
Our
1972).
though you
It
does not appear
may
wish to
LVT‘
useful to reprocaat these reports, al-
cite these sources.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
MF:ig
Resnick, R., Fink, M., and Freedman, A. Cyclazocine Therapy of
Opiate Dependence - A Progress Report. Comphehenb. Psychiat. 12:
491-5023 1971.
Zaks, A., Jones, T., Freedman, A. and Fink, M. Naloxone Treatment
of Opiate Dependence. JAMA, 215: 2108-2110, 1971.
Zaks, A., Fink, M., and Freedman, A. [ralpha-acetylmethadol in
Maintenance Treatment of Opiate Dependence. JAMA (in press).
�
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Text
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mfp-05-00-026-1-084
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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http://exhibits.library.stonybrook.edu/mfp/files/original/88dd8826ac2bdb1830ab8b25646391ad.pdf
9803ce821f4e7b2282746087a68be1b0
PDF Text
Text
ruv-v—u
mow—w‘n.mm‘la‘”"rfiv’ni~xfim“r4-'
,
_
,
,
.
.
February 7, 1972
fir. Stanley Einstein, Ph.D.
Associate Director
Division of Drug Abuse
Associate Professor
Dopartannt of Provantivo Madlcino
&
Community Hoalth
Harriaon S. Martiand Hospital
85 Bergen
Nauark,
E
Stroct
Jorooy 07107
How
Dear Stan:
It
1- an intoroating program that you are planning in
and of May. I would liko to attend, but can do so
Israel aadthe
only
if
funda
for travel are
nada
available.
Sincerely yours,
Fink. H.D.
Proteaaor of Psychiatry
Max
i
'1‘
y".
w
”77'1”"
'wv—x
mu»
,‘m,
Y—vvrww.—v—wl’—-
a...”
v.
um-nwav-n—w
.
HF:13
1
....
---
Wyn“
�
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mfp-05-00-026-1-086
Date
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1972
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/20d6f69b783fde93c82c861571e138a1.pdf
7d63ef37831f129b2b2e55d13704e834
PDF Text
Text
February 7, 1972
Dr. Frank Veress
Director
ICD
Mental Health Clinic
New
York,
340 East 24th
New
Street
York
Dear Frank:
The program of seminars you outline is so extensive that
be necessary to discuss the best way to satisfy your request.
special subject is the use of long term phenothiazines', for
should this be an important aspect of your treatment program, there
are some new compounds which require evaluation - an injectible drug
for 3—4 weeks, and a 7-day oral drug.
it may
Our
request.
It
may
be useful for you to
(369—7900).
visit
my
labs and discuss your
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
MF:ig
�
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mfp-05-00-026-1-087
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/41d5481e805357b66b5ae9285e4ba76f.pdf
706cbcbd4fba8272bf6500c4c3ae3f26
PDF Text
Text
E
February 7, 1972
Dr. Juan de Dios Pozo-Olano
21 Webber Avenue
Bedford, Massachusetts 01730
Dear Dr. Pozo~01anoz
Neither of the articles you requested are available.
Psychiatric Research Foundation of Missouri, Publication No. 65—
10 was a preliminary report of our EEG
sleep classification studies,
and was recently much elaborated and published in EEG Clinica£ Meadophyéia£.,,27= 76—83, 1969.
—
Psychiatric Research Foundation of Missouri, Publication
No. 66—1, a manual
and no copies are
prepared by Shapiro and myself, is out of print
available.
I have not yet seen your report on computer studies of
brain waves, but would be most interested in sharing a copy with
my associates.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
MF:ig
�
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Correspondence to: Pozo-Olano, Juan de Dios
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mfp-05-00-026-1-090
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/f28e33fa1acf043e0bb55807ef9f35f3.pdf
27d7263df3b0304fa63619217fa58686
PDF Text
Text
February 5, 1972
Paul Janssen, M.D.
Janssen Pharmaceutics
Beerse, Belgium
Dear Paul,
I have
first
You gave me so much
sorted
my
thoughts
to think about during
this week-end.
my
visit, that
I am most delighted that such longer acting narcotic antagonas R 15497 provide a basis for further development. Should the
minimal toxicology data, and supplies be available, we will file a
research IND with the FDA, and undertake the clinical testing to assay
the dUration and extent of narcotic antagonism (measured as the response
to intravenous heroin, 25 mg/2 cc saline/2 minutes) in post-withdrawn
opiate dependent subjects. We would also evaluate any agonistic features.
ists
Should
it
prove to be an active antagonist with a duration
greater than the available
the long-term clinical
compounds, we
trials.
will support
and undertake
I called Dr. Allan Green (U.S. Special Action Odfice, The
White House) and Dr. Jean Paul Smith (National Institute of Mental health)
Center for Studies of Drug Abuse) to tell them that I had reviewed some
of your compounds of interest; that these had been tested by the
University of Michigan and the data were in the appropriate archives;
showing these compounds to be similar to others already under investigation;
and that prior to further study, they required, as with M—SOSO, additional
formulations of supplies and animal toxicology studies to satisfy the FDA.
Dr. Robert Rees also called and I repeated these observations.
variety and special characteristics of your many new
fascinating. 0n the return flight, I read the many clinical
reports carefully, and am impressed that penfluridol should be an
The
compounds were
important improvement over our experiences with fluphenazine enanthate
and decanoate. I would like to evaluate penfluridol in our V.A. unit.
I have given the data to my associate, Dr. Alexander Don, and we will
write to Dr. Stevens at MsNeil, to ask him to visit with us on his next
trip to New York.
�.
L“
man‘s
“ac-'9.
Paul Janssenll.OOOIOOOIOOIIOOOOIOI. 2 IClo...-OIOOIIOOIIIIOFebruary 5, 1972
The usefulness of tetramisole as an antihelminthic is
dramatic, and the possibilities in oncology most exciting. It is the
alleged antidepressant activity, however, that interests me. We are
assaying one compound, ORE 8063, from Ortho Research, in our EEG
screen, but our methods may be more appropriate to examine the
possible central activity of tetramisole. I will call Dr. Bill
Pollack as you suggested.
With regard to haloperidol in addiction, I have reviewed the
available to me, and the suggestion by Lal is interesting,
though poorly substantiated.. I have intererted an experienced member
summaries
of my staff, Richard Resnick, to examine the data and he will design
a study, which will run in parallel with the ongoing trials of narcotic
antagonists.
I enjoyed discussing and reading the descriptions of the
compounds
other
in your catalog. You are to be congratulated
many
and
the
Special characterittics of your products. A
on
variety
30-day narcotic antagonist would complement your list most dramatic-
ally!
visit
visit
Your hospitality was exemplary; your family charming; and the
most memorable. Please give Dora my best, and trust that your
'down under' will be exciting and interesting.
My
thanks for your many, many kindnesses.
Sincerely yours,
“Whittx’GVG—"m'
,_
rw
m"‘-v.
waw-vwmcm-mmwui-Wmam
7r—’
wai'
Max
Fink, M.D.
Professor of Psychiatry
�
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mfp-05-00-026-1-093
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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http://exhibits.library.stonybrook.edu/mfp/files/original/2bb86db44dc8b2054e93dee5641b432d.pdf
fe9f53703cee4624561bcd909aeba5cc
PDF Text
Text
February 4, 1972
Gary Boyer
>m‘o;r.w~
wqwr.w..—WV....<
.,,.,m-W
Center for Studies of Narcotics
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland
Dear Mr. Boyer,
“A”,
W.-
.,_,,.,.,.._
.—-.,
gmrfl—mw
As Dr. Durnbush explained, we have become most interested
in dissecting the different responses we have observed in chronic
hashish users in Greece in smoking hashish, U.S. marijuana, and THC.
availability of concentrated
The
an opportunity to
men.
~
dissect
some
THC-A-8,9, CBD, and
CBN
of the responses of these
may
provide
'tolerant'
v...»
weuvv—m-K'fl'”
.nmw
Enclosed is the official BNDD order form, 222C for the
substances requested, for use in studies under contract HSM 42—70-98,
in Greece.
n."
it
We
will be visiting
expedites delivery,
Many
but,"
we
Dr. Petersen on Thursday, and
with you that morning.
meet
can
thanks.
Sincerely yours,
-
ru
-,»~yu—.~uw~
.
(Jenna-Ar»;
1'
r
~
Max
Fink, 24.0.
if
�
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mfp-05-00-026-1-094
Date
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/35cd20a3e4c23576e00ac7a8cfc9e0b7.pdf
d6ff1a0c7699d04031672e48c4749d91
PDF Text
Text
r‘—¢""
:
rwr
January 25, 1972
Eugene Vogin, Ph.B.
FDRL
Haspeth,
New
York
Dear Gene,
I have read the final renort on the delayed release
preparation for narcotic antagonists, and feel that much progress has
been made. Surely, the effort should not be discontinued.
With this in mind, I have asked Dr. Freedman to file
a copy with the flew York State Narcotic Addiction Control Commission,
and to enquire 6f the NINE and SAODAP whether they have an interest
in continuing this project. Meanwhile, I would suggest that you
file such requests as you may wish with Dr. Bergner of New York or
other agencies as may be available.
My
important study.
thanks for your cooperation and
interest in this
Sincerely yours,
?'1ax
Fink ,
PA:
0
D
0
Professor of Psychiatry
�
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mfp-05-00-026-1-101
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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http://exhibits.library.stonybrook.edu/mfp/files/original/73add6c7eb8a04b45684a5fe2e51ee85.pdf
968de0cf9634c30aeb0353540b3b8757
PDF Text
Text
January 24, 1972
Walter Essman, Ph.
Queens College
Flushing,
D.
New York
Dear Walt,
I would be pleased
if
you would consider an evaluation of
the central effects of 01—63, the l~10 polypeptides of ACTH, with a view
to elaborating the observations of DeWied and of Indrocki. We have
assessed the EEG effects in volunteer males, and in our pilot study have
observed systematic changes to 10-12.5 mg intravenous. The changes are
seen withing a half an hour. The effects are more prominent and somewhat
unpleasant in dosages of 15 and 20 mg. These data are insecure, however,
and require verification in a systematic study, which I plan to undertake
this spring.
Should you wish to study this compound, the monitors at
Organon are willing to allow some of the material to leave my laboratory;
and should there be some eXpenses for the chemistry, I amy be able to
obtain some support. I am most interested in your opinion as to whether
the
data justifies the conclusion that the drug may have effects
and thus may justify studies in man during the ECT process.
I had suggested such a study to Dick Abrams, and it was he who reminded me
that your methods are probably much more sophisticated than our human
on
DeWied
extinction,
methods
for such evaluations.
In addition, I
am
I will call
my
enclosing copies of the reports sent
his ddta in your
presentation at the meetings in April.
by Dr. Dunn. I would hope
that
on
you would include
return later this
me
month.
Sincerely yours,
Max
Fink, M.D.
""u
"”1“
A’WUW“
P.S.
Can you
vet
my
application to the Neuroscience Society
7
Thanks.
�
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Correspondence to: Essman, Walter
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mfp-05-00-026-1-102
Date
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
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-
http://exhibits.library.stonybrook.edu/mfp/files/original/924dd4519bde94f661d0d855f83f9a75.pdf
0df004d04730e8bc29d86d0013ac3a3b
PDF Text
Text
,.—VV_,.
...
January 24, 1972
Charles
Inturrisi,
Ph.D.
Cornell University Eedical College
New
York City
Dear Dr.
Inturrisi,
Enclosed
is
a sample of
MK—790,
which you requested.
We are not, at present, planning intensive studies of methadone.
Nevertheless, I have sent your letter and reprint to Robert Levine, M.D.
of my staff, for his consideration. Should he or his associates wish
to establish a study, he will contact you. It will be necessary for
a protocol to be written and approved by the appropriate commitees of
this medical school, and I presume of your ownv- but those details can
wait on some common interest.
for the assay of MK~790, then
in
interested
correlating the blood levels of
definitely
thsi compound with the clinical course of our subjects. I wish you
we
would be
Should you develop methods
success, and should you achieve the result, olease call
me.
Sincerely yours,
Max
Fink, N.D.
Professor of Psychiatry
cc: Robert Levine, M.D.
�
Dublin Core
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Title
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Correspondence
Text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Inturrisi, Charles
Type
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Text
Identifier
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mfp-05-00-026-1-103
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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The Max Fink Collection
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/24129908057cb5d899572c20e4d4ebc2.pdf
5712c4bbd154139fa914a45229b9efc1
PDF Text
Text
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January 24, 1972
G.
F. Blane, Ph.D.
Reckitt & Colman
Hull, England
Dear Cary,
The Lord
preserve us from.the enthusiasms of childred
!
Your letter about the M5050 situation was most welcome, but
the situation is murky, confused, disorganized, and typically American—during the War, we described the situation as SNAFU.
To recapituiite: our laboratory became interested
in the antagonists in 1967. We heard of diprenorphine and contacted you,
as well as Lederle. They were uninterested~~ you and we were. We proposed
a study of the animal toxicology, peior to obtaining an IND to assess its
activity in man. We requested funds of the New York State Commission,
but were denied. We tried NIbiB, the Cityoof New York, and private donors-~
and each
felt that
such
trials
were the expense of
industry.
tried Nlhi,
and they were receptive, and.
Meanwhile, the White House
appointed a brash, young man to h.ead its program; and he asked for assistance
from other brash young men, without experience. Nevertheless, when they
called me some weeks ago, I shared the full file with them, for
is
irrelevant to me who provides the support for the animal work. They
called to ask how much material I had, how much would be nodded, etc. I
answered, openly, and offered the material in hand to start, and indicated
that I would write you for additional material as needed.
Last
summer, we
hence the application which you read.
it
last week, Dr. Green told me that he had assumed full
the program; that he had called you; that there were
for
responsibility
the usual bureaucratic complications of the precedence of a U.S. grant to
do the work of industry, and who would get the rights if the material was
successful, etc. I suggested he review the massive contracts between the
military and industry, and that he disregard the trivial amounts necessary
heae. But, he indicated, that I did not understand his many problems, etc.
Then,
MIME has indicated that they will fund the grant
of
first April; and the City of New York has indicated that they
fund
animal trials, if I guarantee that we would have enough
the
will
do
the clinical work thereafter (which I did); and Drs. Green,
material to
about the
Meanwhile,
Jaffe, et al. are
runnung about.
.
.
.
,
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My reaction is similar to what it was last summer—- to take
holidays. I am off to Greece for the week, and hopefully, the various
competing agencies will resolve their problems.
some
Our position is what it was two years ago-- we are prepared
interested in establishing the clinical efficacy, dosage range,
toxicity, utility, and anything else that may be interesting of the antagonists
in opiate dependent subjects. We are now embarked on essays of naloxone
and
pamoate; have been promised l-cyclazocine next month; and
BC
2605
in
Should some agency probide the basis for an IND, we will do
what we can-- and hopefully, R 8 C will make some material available
for our studies at that time. Or, should I husband my present supply,
and let MIME, Green and Jaffe, and New York City obtain their supplies
from you ?
April.
Incidentally, in the usual disorganization of our governement,
will probably get out funds, eben if the toxicity is done at the
military centers in the v.3.
we
I look forward to meeting John Lewis again. There may be
error, however, for I believe the Drug Dependence meetings are
to be held in the late Spring in Ann erbor and not in February-— unless
some
he
is
coming to a committee meeting and
scientists in the field.
that is not
open to the
Keep weal, and do what you must to secure your compound's
study. While I would like to be its monitor, I do not see how I can ask
us are brash, and unSOphisticated, and tend
it, for the forces aboutwherever
and whenever they can.
to assert their powers
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Blane, G.F.
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-104
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
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Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Contributor
An entity responsible for making contributions to the resource
Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/fdcaca3b0892012fafc8b3072fe9064d.pdf
27c74afc5aa030f7e73fddba975ac44c
PDF Text
Text
,.....
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January 24, 1972
Elmer Gardner, K.D.
Division of Neuropharmacology
Food a Drug Administration
Rockville , i'iaryland
Dear Al,
It
pleasure to hear your rational presentation
that your approach will bear happy
fruit, in establishing feelings of cooperation between the investigators,
industry. and the Administration.
before the
was a
and I do hepe
ACNP,
The advances in EEG quantification have been rapid. Much
of the information has not yet appeared in press, although Jon Cole
just published a study classifying fenfluramine as a sedative compound
(Paychophanmaco£ogia 22:369-383, 1971). I am enclosing some preprints
and reports of our recent studies, and trust that these may interest
you and your
associates.
My
best regards.
Sincerely yours,
Fink, M.b.
Professor of Psychiatry
Max
é
o
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Gardner, Elmer
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-105
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/f961ff8ba29e8f66876d93fe95b6a6b1.pdf
290db0f8d563543a9c2ed5e35c248a01
PDF Text
Text
"#7,“. ,WT...‘,. he. \u..;
.,_
.va-r'fi""m w ‘. I.run».. P . ...,., “a ”“5,-».mv: v, J
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January 24, 1972
S. Clyde
Strickland,
Herck, Sharp
West
M.D.
Laboratories
Point, Pennsylvania
&
Dohme
Dear Clyde,
It was a pleasure to discuss-the EEG and methadol
research programs, in Las Vegas. As I indicated, our report comparing
methadone and lualpha-acetylmethadol, has been accepted for publication
in the Journal of the American Medical Association, and should appear
within the next two mohthe.
would like to extend our studies, and I am writing
to request additional supplies of l—alpha-acetylmethadol, should
We
still be available from your laboratories. Since it will require
12.5 grams/subject/year for an evaluation, we could use up to
1250 grams/100 subjects; or any portion thereof that would make the
"these
study possible.
Many
thanks.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
P.S. Should you be able to make a supply available, I will submit the
necessary BNDD forms on request.
-
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~
Au
-
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Strickland, Clyde
Type
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Text
Identifier
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mfp-05-00-026-1-106
Date
A point or period of time associated with an event in the lifecycle of the resource
1970
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
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Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
An entity responsible for making the resource available
Contributor
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/f8441eb9011be5aff687406248336d77.pdf
b871e542f56c99df22ea014cf3683b9c
PDF Text
Text
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ww.wi_w/w. ., p;;,~'~1—$b‘—vaw~_."im snug—Wm..-
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January 24, 1972
Samuel Kaim, M.D.
1200 N. Vash Street
Arlington,
Va.
22209
Dear Sam,
It was a pleasure to discuss the programs of the V.A.
with you in Las Vegas; and I do look forward to joining you in the
sessions in St. Louis.
There
is
a need
for the
NIMH
and/or the
V.A.
to undertake
a more extensive evaluation of l-alpha—acetylmethadol. I believe the
V.A. can do it, and am taking the opportunity to enclose a copy of our
report, comparing methadone and l-alpha—acetylmethadol. The report has
been accepted by the JANA, and should appear within the next 6 weeks.
have continued our studies since the report was completed,
and the present group of patients continue to fulfill the expectations
established by the patients in the study. I would like to establish such
a study as part of the programs at Stony Brook.
We
My
best regards.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Correspondence
Text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Kaim, Samuel
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-107
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
A language of the resource
en-US
Format
The file format, physical medium, or dimensions of the resource
application/pdf
Publisher
An entity responsible for making the resource available
Contributor
An entity responsible for making contributions to the resource
Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/e738cce80d381f0851763e7f4ba75bb5.pdf
5f60d46f881c54759e93fcad7a4ef744
PDF Text
Text
,___
.,.
,
,.,-,..A.._r.:
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n-
-
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nvr.._.r~.,..,..v.;.x.—;~,7
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was.
January 24, 1972
unsw—
,me
Nathan 8. Kline, M.D.
Director of Research
Rockland State Hospital
Orangeburg, New York 10962
Dear Nate,
As you know, I have been most
interested in the development
of narcotic antagonists as a treatment ior opiate
dependence. After many
years of effort, the model has been supported by clinical studies, and
the qualities of an ideal antagonist have been defined. The National
Institute of Mental Healhh, the SAODAP of the White House, NACC
the
State of New York, and the City of New York are all interested inof these
programs. They are making research funds available, and their
support
has much to commend
it.
However, the principal agencies that have the facilities to
produce the necessary formulations, the industrial laboratories,
preoccupied by their prior committments, and some effort should bearemade
to bring the needs of this program to the attention of the formulating
chemists. With this in mind, I would ask that you consider approaching
some of your foundation friends, with the idea
a special award be
established for the production of a successful that
formulation with the
following characteristics:
specific narcotic antagonism, similar to naloxone;
duration on single administration of 90 days, with
antagonism to injected heroin, 25 mg/ch/2 minutes;
tolerated by man ('safety'); and,
without agonistic features.
is the most likely starting substance now at hand, but other
candidates may be l-cyclazocine, diprenorphine (M—SOSO),
other
specific antagonists now under study at Bristol, Geigy, or orother
labs.
Naloxone
A single prize of $50,000
or $100,000 for 36 months, well
publicized and supported by the authority of one of the leading
found~
ations may serve this program handsomely.
I hope you agree, and raise the question at the best levels.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychigggy
r//\
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Kline, Nathan
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-108
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
A language of the resource
en-US
Format
The file format, physical medium, or dimensions of the resource
application/pdf
Publisher
An entity responsible for making the resource available
Contributor
An entity responsible for making contributions to the resource
Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/7faee20af0f0ed8f987ef80b75b8dedf.pdf
bb8a3dca55d8d407502601d7f9dae5a9
PDF Text
Text
N”.
January 17, 1972
Dr. Elna: Gardnar
Division of Nouropharnacology
5600 Fishers Lano
Rockvillo, Maryland 20852
Dear Dr. Gardnat:
Enoloaod 1a our application Cor an Inn for 01-63,
a potential paychoactlva compound which in to be coated in
our
EEG
profila syatau.
Many
thanks.
Sincaroly youra,
Ha: Fink, 1-1.1).
Profoooor of Payohiatry
“£313
inc.
Aw—ngrm: ..WV'17.V
4-1.
—
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Gardner, Elmer
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-109
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
A language of the resource
en-US
Format
The file format, physical medium, or dimensions of the resource
application/pdf
Publisher
An entity responsible for making the resource available
Contributor
An entity responsible for making contributions to the resource
Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/df88f9c38d9740909f74906afd814f93.pdf
5f42dda4bd2b465097bde63d5cc8470e
PDF Text
Text
M
E
M
0
R A N D U
M
January 17, 1971
To:
Alfrod Froddnnn,
mm:
mm Pink, 21.1).
SUBchrzz Protocol
Addlttion
~
M.D.
High Dooo
CD3
Itootnont of Alcohol
Tho ottoohod protocol 18 on intorooting expansion of
the ongoing studio. of drug dopcndonoo. Constantin; out recon:
difficultioo with the KING Roooorch Connittoo, would you one:
with Dr. Lovino and porhopo, v0: this protocol by calling Dr.
Lohr?
Thanks.
HFalg
Ehc.
�
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mfp-05-00-026-1-110
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1972
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
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f6cc52c561d96e0f73e0434ea2909127
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wry-m.
a—u—r
~rvr
m
1
a
wwwarnmuw-ru.
'1.
aw.-
January 17, 1972
Maxwell Gordon, Ph.D.
Bristol Laboratories
Syracuse,
York
New
Dear flax,
pleased to have the opportunity to review the
clinical pharmacology data on Clomacran— SKF 14336, for I had heard 05
the compound but had not read these dlta. It is a well studied compound,
and there is sufficient conventional evidence that the drug has antipaychotic activity. One of the questions that should interest you
is the possibility that it may have unique pronerties, but this hypothesis
is questioned by the two comparative studies.
I
was
Considering the extensive clinical studies, the EEG analysis
will
'after the fact'. In our recent work, we have ftcussed
on those compounds with interesting animal profiles and with limited
human data; for an EEC analysis is time consuming, and we have yet to
'prove' that this technique has merit. An analysis at this time would
add little to your body of data that would be helpful to your clinical
or your FDA position.
indeed be
Many
thanks for the opportunity to read this material.
Sinceeely yours,
Max
Fink, M.D.
Professor of Psychiatry
�
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mfp-05-00-026-1-111
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1972
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-
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4811070a28c5d923b7b3d2b4afa891f0
PDF Text
Text
,,._,,~_ 7....‘l‘n.._....,..v
V
.
.
,
,
,
w,
.
,
...
t
..‘t
...
.
..
..
...
January 15, 1972
‘—
»:u
n,
-
Jerome Levine, H.D.
Chief, Psychopharmacology Research Branch
National Institute of Mental Health
Rockville, Merylhad
fl-fimv'70‘wfi-
....
Dear
Jerry,
have been asked to examine the EEG pragile of
clomacran (SKF 14336), with a View to defining any unique preperties
of the compound. From the availahle data, it appears that the
We
clinical studies are extensive.
would be helpful for me to have an opportunity to
read the summaries of the ECDEU studies of these compounds. Is
It
possible to request such a readwout
it
?
fiany thanks.
Sincerely yours,
Max
Fink,
M.D.
�
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mfp-05-00-026-1-112
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1972
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http://exhibits.library.stonybrook.edu/mfp/files/original/ae226fc94d346a8e1f9d2c7ae52f4747.pdf
700b725f7b7e49a42031bbdc0a1e0817
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H E H
0
R A H D
U M
January 1‘, 1972
TO:
Alfred Freedman
FROM:
Max
SUBJECT:
Study
Fink
at Hontroaa
V.A.
is internataa 1n boginntnx lone paychopharnacology studies. The attached protocol examines the relation
of EEG, blood lavol, and behavior of butaporaziuo in $0h180pht€*
Andy Don
nia.
The protocol has bean accoptad by Dr. Barrio and Dr.
Rackow, and I on writing to obtain the cooyeratioouof tha chan—
1otl at A. H. Robina for tho blood atudiao.
Ara
MF:13
Enc.
thara
any other
atop: nocaooary?
�
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mfp-05-00-026-1-113
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1972
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1b5364b7db94d176e3dfa34b15c3da4d
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Ianuary
Dr.
14,’ 1972
Hilliaa Tabor
A. B. Robina Company
1407 Cummings Drive
Richmond, Virginia 23220
Dear
Bill:
Enclosed are two copies of a protocol to assess tho
level, and behavioral effects of the formulations
of butapcrazine; and a copy of the curriculum vitae of Alexander
EEG,
blood
Don.
will request supplies of both cone
tablet butaporazine, and a small amount of placebo
of either formulation; your willingness to file this protocol
contrate
In the study,
and
we
as a supplement to the concentrate IHD; and the cooParation of
the laboratory ~ to assay the blood ramples for butaperazine
levels.
Dr. Don was
my
student in Hiaaouri. no taturnad to
South Africa to raise a family, and than emigrated to the U.S.
in Nova-bar 1971. He is capable, and interested in the special
problcna of drug availablility. For this reason, I posed the
quastion of this protocol.
The study
will
be reviewed by the appropriate insti—
and should be ready to begin by
tutional authorities shortly,
nid~¥abruary.
to Jaca
Many
thanks for your teaporation and
and Fred.
my
best regards
Sincerely yours,
Fink, M.D.
Professor of laychiatry
Max
Hrzig
Enc.
�
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mfp-05-00-026-1-114
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1972
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666d756c0f01778bcbd77ea92799b113
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,
fir. Hilton
Feldman
Treasurer
Grune a
January 12, 1972
Stratton
I11 Fifth Avenue
New
York,
New
York 10003
Dear Hr. Felduan:
vriting to request a quotation for 50 and 100 capies
of the February 1972 issue of SeminaAA in Paychiatay, on the topic,
Electka Canvuléive Thenapy, at the author's discount price.
I
am
Separately I have requested
for tho eantribucors.
100
reprints of each srticlc
Sincerely yours,
Max
Fink, H.D.
Professor of Psychiatry
31:1;
cc:v
Hill Rafael: Valdez
�
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mfp-05-00-026-1-115
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1972
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902b4e06c9159ad07ba8cf99844c9603
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me
I
I
I
I
I
I
I
I
January 12,
1972
files Rafaela Valdez
Rnprint
£=£annger
Crane & Stratton
111 Fifth Avenue
Nay York, Haw York 10003
Dear Miss Valdsr:
With regard to tuc February 1972, Seminaab in Paychiatay,
on the topic, Electao Convulblve Therapy, Volume 4. Rumber 1, we
would like to purchase 100 reprints of each article beginning with
page 3.
.—w"nw:u-—-r‘mmmwmw'
There are
8
articles.
tation for this requnac?
is acceptable.
A
Hould you provide a sinala quopurchaae order will follow if the price
Sincerely yours,
Ha: Fink, M.D.
Profassor of Paychiacry
31:13
�
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mfp-05-00-026-1-116
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1972
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73abb1859b0897835f3676db43b616ec
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“nu-Av]?
—.—-rvm,~a-.-~mww .
n -.:.r-
.1“
;‘ch-
~
~
music...
January 12, 1972
Y.
Langlois,
M.D.
Pharma—Research Canada, Ltd.
Pointe Claire, P.Q.
Dear Dr. Langlois,
I have been delayed in completing the protocol you requested
by the ongoing wprk, but will complete the program outline shortly. The
data submitted is sufficient for my purposes, and we should plan to
start the pilot phase with doses of 25 mg, and increments at this
dose.
To
compare the compound with fenfluramine
will require the
be able to
availability of this agent in identical capsules. Will you that
we obtain
arrange for.the supply of this standard or is it expected
this
compound
7
Thank you
for your interest.
Sincerely yours,
Max
Fink, M.D.
�
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mfp-05-00-026-1-117
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1972
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5724b110978a9e716a4e5a739e470602
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January 12, 1972
Drs. Ivor and
once Small
Indianapolis School of ficdicine
1315 West 10th Street
Indianapolis, Indiana
Dear Dru. Joyce and
46202
Iver:
«a..-
,-...,..—_A
.,
-m...._,
an,“
of
I want to thank you for your contribution to the issue
in Pzgchiatdy. I am grateful for your couperation,
pleased to make available 100 reprints of your contri-
8£m£naAA
and
I
am
bution or
my
expense.
If you nave already ordered
change your order with this in mind.
reprints,
you may with
to
I harm your suggestions for title changes for the ECT
seating in April, and as noon as I have an opportunity to review
those with the program connittce, I will answer your letter more
spocifically.
My
boat rcgards.
Sincerely yours,
flax Fink, M.D.
Professor of Paychictry
33:13
�
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mfp-05-00-026-1-118
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1972
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f9a8a84055d3742d0c089f8476fd010a
PDF Text
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Janunry 11, 1972
or. Ferris Pitts
1035 Bellview Avenue
St. Louis, Missouri 63117
Dear Peta:
I want to take this opportunity to thank you for your
contribution to the February 1972 issue of SeananA in PaychiaIAg.
I have seen the page proofs and the issue should be out within
four weeks.
a small payment for your participation in this volume,
I have asked the publisher to aako available 100 reprints of this
urticle without cost to you. You may wish to review your reprint
needs with this in nind.
As
fiy
bolt regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry
Max
flrzig
�
Dublin Core
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Title
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Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Pitts, Ferris
Type
The nature or genre of the resource
Text
Identifier
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mfp-05-00-026-1-119
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
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<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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Correspondence -- Correspondence
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The Max Fink Collection
Description
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Rights
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<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/92c6a1ba9e74e87570aca835f06fe5da.pdf
85f8cb5518a9110ad150e630839123fb
PDF Text
Text
January 11, 1972
Dr. William Gal?
Biometric Laboratory
1145 Nineteenth Street, N.w.
Washington ,
20036
D. C.
Bear 8111:
Enclosed are the data sheets and covering notes for our
study of GP-41299. we assayed this clinical study following the
demonstration of Specific
Tuero
scale data.
is
EEG
activity.
one general purpose
scale used, for our anxiety-
Should there be specific questions regarding the data
shoots, please call the study coordinator, also Sauna Durbin at
212-360~6746
or
Dr. Abrams
Thank yOu
at
212*360—6746.
for your assistance.
Sincerely yours,
Max
Fink, x.D.
Professor of Psychiatry
firzig
Enc.
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Cuy, William
Type
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Text
Identifier
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mfp-05-00-026-1-120
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/a5be23631a55a355524cc0047b17b437.pdf
358711f35e2cab1fb4b257eedf7f926c
PDF Text
Text
January 6,'1971
TO Wflflfi
IT fiAX COfiCERfi:
Doctors Professor aha: Dornbush Ph.D. and ProfessorflewJanYork
Volavka, H.D. are mambera of the Department of Psychiatry,under an
fiadical College and are carrying out studios in cahhabis
Grant 18172 and Contract “5% él~70~93 (Studies of Marijuana Users
in Groece).
Under the terms of those grants, Doctors Dornbush and
Volavka are carrying with them marijuana oravidcd by the Rational
not exceeding 500 grams
Institute of fiental Realth in an amount
which
an import document has
and 200 grams marijuana ylacebo, for
of
Greece.
been obtained {rem the government
thom sup—
their return, oitner or both may bring with
invcs~
by
our
forms
provided
plies of hashiah or cannabio in other
attached.
tigators in Greece. An import permit for this is
On
This inboratory operates unéor the appropriate regulations
of the United States Bureau of Narcotics and DongcrOus Drugs and the
Sttte of flow York, and copies of these documents are attached.
In the evcnt that any questions arise regarding the truns~
or from
for of those materials from the United States to Greece
undersigned
the
Grooce to tho United States, we urns you to contact
Na~
at 212c369-8‘83 or 516-666—56‘k or Dr. Robert Peterson at the
tional Institute of fiontol Heclth (301w443w4663).
In the event that problems aria. in Graces,
we urge you
of
Biological
to contact Professor Constantine Miras, Protcnuor
Costa: Steand
Profossor
Chemistry, Univuroity of Athens (771«155)
(6&3—2025).
Athens
of
fania, Professor of Psychiatry, University
�Thin projact has been brought to the attention of the
American Ambassador to Greoce, Hr. Charles Kennedy and should any
questions arise that should require his intervention, 1 would appreciate your contacting him.
Sincerely yours,
Max
Fink, M.D.
Professor of Psychiatry
flY:1g
Enc.
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: none
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-121
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Contributor
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/7ad918f9a090173eb692cb6860e42e67.pdf
6cfbab8a8a29eb8fafa4a89da56f9c6f
PDF Text
Text
January 6,
1972
Accountant's General Section
Reckitt & Colman
Household Division
Danaon Lane
Hull, England
Dear
Sir:
chloride.
We
We
have received the supply of diprenorphine hydrohave not received a bill regarding charges for
this shipment. It
material, supplied
was my impression that this was research
by Dr. G. Blane for research purposes.
Should there be a charge, we will be glad to
pay
Please submit a specific charge in dollar equivalent.
Sincerely yours,
Max
Fink,
m.
Professor of Psychiatry
H!:ig
cci
Dr. G. Blane
it.
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: none
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-122
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Contributor
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/a5262ad4c7cc3fab21a72035fb552dea.pdf
22515d52a8c9f968c658fcf06be85279
PDF Text
Text
January 6.
TO:
Dr. A. Proud-an
FROM:
Dr. Max Fink
SUBJECT:
Questions on
1)
K
5050 Prepoocl
1972
Fro. Dr. Borgnor
fl 5050 but been shown not to reduce blood pressure or to
interfere with respiration. No EKG data is available.
is widely used in veterinary medicine and
is
it unlikely that cardiotoxic effects would not have
The substance
been
reported,
if
they occur.
have no data as to absorpoion of
2)
We
3)
Because man
istration.
3050 on
is the ultimate target, and
to obtain data from mammals as close to
anticipate going right
human volunteers.
we
4)
H
I
IV
from animals to
admin—
anxious
feasible,
studies with
do not know wuether the technicians at Woodard can give
for 1k days in the rat. I assume they will try and in
the event that it is not possible, I
subcutaneous instead.
Ming
we are
man as
oral
am
sure they will try
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Correspondence to: Freedman, A.
Type
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Text
Identifier
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mfp-05-00-026-1-123
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
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Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
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Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
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en-US
Format
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application/pdf
Publisher
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/8fe0d6a7600d7152ed944a83c614c947.pdf
3881a53af10ea0ce774a338ba31702ea
PDF Text
Text
'—
v“
w
m-rvr-w-v
January 14, 1921Dear
Peter,
you
Thank you
for your
two
letters.
I hope that you have overcome
illness-- it is a shame to miss the early classes, but I
will make these up.
your
know
that
The notes on the Clyde Mood scale were very helpful. I had
already compared the output to the placebo schles and was sure that
the CMS was helpful. Your suggestion of comparing the last five minutes
of EEG to the CMS is a very good one, and I will try to keep it in mind
as the data analyses proceed.
I have asked that you be reimbursed for your travel, and
due course.
.this should arrive in
Your notes about the start of the placebo paper are
good; but I am confused by the request for a return of the general
summary you left with me. The summary I read, I believe I returned.
I have made a folder on placebo/EEG/Irwin, and
is not there; nor is
does Bruce have it. Are you sure I did not return my
it at home; nor
copy to you ? If not, descibe it again, please. (I'm embarrassed,
because in the past I could always turn to kathy and she would
save me from an embarrassing memory 0.
it
Feb 1, and
We
Glasser has just appointed a research assistant to begin
I believe he will Spend much time on the problems as outlined.
shall see something
by mid-March.
Keep working and keep
well.
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: ?, Peter
Type
The nature or genre of the resource
Text
Identifier
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mfp-05-00-026-1-124
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
A language of the resource
en-US
Format
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application/pdf
Publisher
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Contributor
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Correspondence
-
http://exhibits.library.stonybrook.edu/mfp/files/original/ee2c199fb25893ca5308834548c983b6.pdf
08b1c2086db134eeef5704899f0392d5
PDF Text
Text
January 14, 1972
Lal, Ph.D.
University of Rhode Island
Mr. Harbans
College of Pharmacy
Department of Pharmacology
Kingston, Rhode Island
&
Toxicology
Dear Dr. Lal:
Thank you for your kind invitation to participate in
the volume, ”Drug Addiction w Experimental Pharmacology.” Our
data, relevant to the interest of your readers, was presented
in 1971 in Clouet's volume. As tne results of our ongoing
work are not yet in a form that will allow publication, I re—
gret we cannot contribute to your interesting volume.
Sincerely yours,
Max
Fink,
M.D.
Professor of Psychiatry
MF:ig
�
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Correspondence to: Lal, Harbans
Type
The nature or genre of the resource
Text
Identifier
An unambiguous reference to the resource within a given context
mfp-05-00-026-1-126
Date
A point or period of time associated with an event in the lifecycle of the resource
1972
Creator
An entity primarily responsible for making the resource
<a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a>
Subject
The topic of the resource
Correspondence -- Correspondence
Relation
A related resource
The Max Fink Collection
Description
An account of the resource
Rights
Information about rights held in and over the resource
<a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a>
Source
A related resource from which the described resource is derived
Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).
Language
A language of the resource
en-US
Format
The file format, physical medium, or dimensions of the resource
application/pdf
Publisher
An entity responsible for making the resource available
Contributor
An entity responsible for making contributions to the resource
Correspondence