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                    <text>May
BIL.

19, 1971

Tuba/L
Wan
Robins Co.

A. H.

1407 Cwmuingb Waive

ﬁd’lmond, Vugiwéa
‘Detm BLUE,

I am bending nude/L éepmate. cave/r. the 541m! nape/ct on
Pawns 05 Fenﬂmmlne, Ambwm and Damnanphuwnine
Thu bzwnpomtu copied, a all the
Mom
Aim/tied plwcedwcu which we wed in anatyzing me gengwmmlne
data. I Auggut that you keep tlu'A capg a5 a max/ta 05 you):
deco/nib and me the aux/mated MPOJ‘l/t Aubmltted but weak.

"EEG
12:

Vchm”.

I want

paueme

a

to thank

ﬂux

you once again 604 you); coopemxx’on and
Atudy.

3&amp;ch

goww ,

maﬁa/54M 05
Alf-312x

Paychéaw

�</text>
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                    <text>May

18, 1971

Dr. G. F. Blane

Divisional Projects Manager
Reckitt &amp; Colman

Dansom Lane

Hull, England
Dear Dr. Blane:

if you

received the enclosed letter dated
as of that date, and
there have been no material changes since.

March

I db

not

5, 1971.

know

It represents the status

are trying very hard to obtain funds, but with the
present pressures on both state and federal funding to sustain
the war in Viet New and our war against poverty, the fight
for addiction seems somewhat hopeless.
We

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
811C.

�</text>
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                    <text>May

18, 1971

Dr. Ralph Jacobson

Laboratories
Stewart
Garden City, New York

Endo
1000

Dear Ralph,

Enclosed is a copy of our proposed study of naloxone, as
submitted to our research committee. I would appreciate any
criticisms or suggestions to improve the study.
make

Our thanks, once again,

this study possible.

for your interest

and

efforts to

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>WWW

__.

.
.7__

n.

*m

mmmmv

May

17, 1971

Professor Henri Gesteut
Centre Hospitalier et Universiteire de
13

—

Marseille
Merseille (59), France

Deer Professor Centaur:

It is a pleasure to respond to your invitation to participate
a symposium on cannabis in men. The organization of such a
session at this time may be useful, and we vould be pleased to

in

participate.
Our

have studied cannabis and THC in volunteers and patients.
reports on the effects on perception, heart rate and memory
we

are in press, having been presented in the v.3. under the title
”Marijuana, Memory and Perception”. Our preliminary report on
the EEG effects under the title, “Herijuens, EEG and Behavior”
will be presented this week at the symposium in ﬂew York.
We

have another study

in progress at this time.

and

believe

can have the date analyzed for a meeting in september. we would
propose a discussion of this EEG, memory and perceptual dste.

we

Joining in this presentation will he Professor

and Drs. R. Dornbush and

J. Volavka.

A. M. Freedman,

To return to Merseille again, after ten
years, would give
e greet pleasure, and I hope that you will be successful in
organizing the meeting.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Mex

me

�</text>
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                    <text>May

17, 1971

Dr. Elmer Gardncr
Food and Drug

Fischer:

Administration

Lana
Rockvillc, Maryland 20852
5600

Dear Dr. Gardncr:
Thank you for the invitation to the wasting of the
Counittne on Hathadonn on Juna 30, 1971.
The

enclosed

issues that

may

latter

raquire

from Dr. Paul Blachly raises some
an answer. My inclination is not

to respond, but I Vbuld appreciate your advice
from this course.

if it differs

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf:kt

FDA

�</text>
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                    <text>May

17, 1971

Dr. William Tabor
Robina Co.
1407 Cummings Drive
Richmond, Virginia

A. H.

Dear

Bill,

"EEG

I am pleased to enclose a draft copy of our final report,
Profiles of Fenfluramine, Anabarbital and Dextroamphetanina

in

Normal Volunteers”, as submitted to Payohopharmacologia.

Separately, I am sending you a complete report which contains
additional data analyses. we found some redundant and abstracted
our experience for the report for publication. You may elect to
use either report for your files and references.
Many

thanks for your

interest:

and

my

best regards.

Sincerely yours,
Fink, N.D.
Professor of Psychiatry

Mar

Mszt

�</text>
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                    <text>To:

I.

A.

H.

?ROM:

Freedman, H.D.

Fink,

DATEr

Mby

17, 1971

M.D.

Proposals for Developing a LonguActing Narcotic Antagonist

SUBJECT:

Establishment of a research center with its own staff.
Since the leadership is in the nepsrtment of Psychiatry, such a
center can be seen as part of a large program in drug dependence,
based at the new Mental Health Center. Since the Center has 3
floors of laboratories, and 250 patient beds (29 already dedicated
to addiction on the 6th floor), it is a logical center for such
1.

research.

will need funds to equip the laboratories, appoint
chemists, pharmacologiats and pharmaceutical specialists, particularly
The program

those interested in addictions.

For equipment (assuming space be made availabe at the
estimating 1/2 the 3 floors.
$850,000
For personnel

Scientists

(lst year)
$35,000
staff

6 9

@
Supporting
each
$50,000

Clerical

MEG.

and

210,000
300,000

“econ-

550,000

__

‘UWWWW‘Vq—‘W’w

,

Supplies

40,00n

Consultants

20,000

The annual budget in years 3~10 should average $750,000, to be
supplemented by special project grunts as may be needed.

�.

—m=

For Consulting contracts to develop a silaatic vehicle,
e.g., Food &amp; Drug Research, Inc.
$70,000
80,000

1970~71
1971—72

‘80,000

1972-73

$230,000

For consulting contract, to develop physiological slow
release method based on non~silastic model.
e.g., Alza Corp.
$300,000
300,000

1971—72

1972*73

$600,000
For consulting contract, based on oil depot preparation
e.g., Dr. Pilpel, Chelsea College, England’
1971«72
1972~73

3

50,000

m_50,000

$100,000
To

develop alternate antagonists
(a) M~5050_Rcckitt

&amp;

Colman

www.crw

wv/

w

l.

Aiimal Toxicology §_l§J000

2.

Intral

w,

“7—,

Dose

Toxicology in

man

$90,000
wmmrww,

39

(b)

trials

year $70,000—100,000

15319.29:
WEN

1.
2.

assay,
dose finding
Supplies of drug

3.

Human

P‘mww‘w’wrm—W"

.r.

Long term
1

.

.iwvwwww

16,000

Supplies of drug20,000
Personnel
__70,000

"v

A-w

$

Human

clinical

trial

$

50,000
50,000

70,000/yr.

�</text>
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                    <text>mn.W—mw~—wr

,

TO:

Alfred

M.

Freodnln,

FROH: Max

Fink, H.D.

SUBJECT:

Dr.

lain

.

,

M.D.

DATE:

May

., Ww.w

.n-

17, 1971

Khazan

Dr. N. Khazan, Associate Professor of Pharmacology
Mt. Sinai School of Hodicino, has exprosscd an interest

our faculty.

I have

“mm..-

at the

in joining

of his work in addiction for a few years. Earlier
roferred to us for our ability to analyze his EEG
tapes. Rb have had an interesting working relationship, and I
bocame aware that he is studying opiates, antagonists, and cannabis.
His work is complementary to our own.

this year

known

ho was

vitae is attached. I would
attention, for possible referral to Dr. Lehr.
His curriculum

MF:kt

commend

him to your

uunu...

mxwr-va-m—u-

~

�</text>
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                    <text>v

“wwwwwwwmﬁm

7..wm-ﬁ.wmm—VWW—w—wrmuW...__._....

"—w—w.

Wem‘

_.__

Hey 17, 1971

Dr. Gordon Marjorrison
Department of Psychiatrv

University Hospital
Saskatoon, Canada

Dear Gordon,

I want to thank you for the pre~puhlication copy of your
study "Electrocnnvulsive lherapyt EEG and Clinical Effects."
I found it very interesting.

First, I am enclosing a copy of the proper citation for
the slow wave EEG differences, and suggest that both the text
and the reference list be corrected in galley. Bro. Volevka
and Veldetein have re~anelyzed this data quantitatively, and
the findings stand.
text, it is clear that the REC behavioral
reported were not replicated. But Table II vielde
another fact, that indeed depression scores increased with
increasing delta (9 &lt; .05, r - +.26 w +.29) i“§ﬁiié”§hx1ecv
and excitement decreased. In this correct?
In reading the

relations

we

I also find the correlations in Table IV confusion. The
negative correlations are consistent with our experience, but the
positive correlation of increased delta voltage and increased
scores in emotional withdrawal and conceptual disorganization
reflects some other process. Are these interpretations correct?

principal difference in our experience is in Table II.
a sun of the observations in schizOphrenic and
depressed patients combined, it may help understand the correlations.
Since the evquotions were done 1 week after a varied number of
trootnento, we voild expect the number of treatments to differ
for the two populations: and the impact on evmptome to differ.
Diagnosis did influence the delta scores on you note on page 5—6,
and perhaps this also influenced the behavioral correlations.
The

If this table is

�""W‘m‘

.m

-

Dr. Marjerrison

We

1..

—2-

are planning another

"rvuvt—v-Huwntmw —mm«qu-..v.—-—w--

May

17, 1971

study, to look into the delta

ECT

and its relation to behavior. In 1956 and 1961
I believed the slow waves after seizures were an outward index

lateralization

of the biochemical changes that underly improvement. Our recent
experiences, your report, and the studies by Small, suggest that
the EEG changes, like the memory changes, are non—specific indices
of brain perturbation, and only indirectly related to the behavioral
consequences. Something like the argument about the need for a
successful antipsychotic drug to induce parkinsonism a very
high correlation but surely not a causal or direct relationship.
—

The

studies should

go on.

Thanks

for the report.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>—-

...,

it

am.

.-

W.W.mmwym.«u

."mw

;
.
'1,V¢r&lt;

.W‘N‘"

--awrrxuvr-u-

m-

,l.
E
E
g.

a“ «vuv—z-”w -v-

»

wam-

v umn

uni-tum“

:

."1'Jr

2-:

:.,:~.~,-|.~w.‘-. .-.1 ”0......

awn/«'3‘ ...,_-,Vu

.. ,v, n... a...»

May

~r .

“w”... ... q...

., ...,.,..

TFFTT“.

.77.”.

7..

-.

,

..._..

J”... .,

15, 1971

Dr. Allen Berger

Associate.Director

Pfizer Pharmaceuticals
Groton, Connecticut
Deer Allen,

Separately, I am sending you two boxes containing
duplicate copies of the report of our studies of doxepin hydrochloride
and doxepin pamoate using the EEG profile methods for determining
bioavailability and dose equivalence. These may be fileé and
submitted as vou wish. You will note that some of the actual EEG
analyses may be obscured by the reproduction and binding process,
but the originals are on file in my laboratory and will be made
available as requested.
I am also sending you additional copies of the summary
and the data summaries. This is the material that will be

report
useful to you.

most

I

am

very pleased with the results, for the technique
clear answers with a minimum of population sampling.

seems to provide
Many

thanks for your

interest

and encouragement.

Sincerely yours,
Max

Fink, rm).

�</text>
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                    <text>5.....- Wymyﬂw‘w.wrwww-

mm... mmrjwmw m—vn-ua
‘

May

IWW W
,

.mr

.—

14, 1971

Dr. Honique Broude

National Institute of Mental Health
5454 Wisconsin

Chevy Chase, Haryland 20015

Dear Monique,
we

are in the middle of an experiment using Delta

9 THC,

66285,
952. The sample is identified
Ten subjects are being used, each receiving, on separate occaaiona,
two doses of 20 mg and two doaea of 10 mg, making a total of 60 mg
of this material.
per aubject. We started with a total of 800 mg
chemical
the
activity
However, a portion was used to ascertain
levels at weekly intervala so that stability and an accurate method
aa 580

—

(ADL

w

16‘32~35).

of delivery might be determined.

find ourselves in need of at least 300 mg more of this
material to complete this experiment. Enclosed is an IRS

we now

same
Form 2513

in this

amount.

I alao take this opportunity to remind you of our request
for 750 gma of marijuana leaf with a 1.5! Delta~9 THC concentration
for the study of chronic effects which will begin in June. We need
this material no later than June 10.
May

Thank you.

Sincerely yours,
xdv

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>1

4
.1.

my

L‘

May

13, 1971

Dr. Michael Beaubrun

University of

Indies

West

Kingston, Jamaica

Dear Dr. Beaubrun,

you by

my

I very

phone

obtaining as

enthusiasm

much

regret the inconvenience I

call yesterday.

much EEC

may

have caused

interested in

are
gets as possible regarding cannabis, and
very much

We

may have overcome more

rational considerations.

my

In View of the time in your study, and considering the
expenses involved, it may be that an intervention now will not allow
for sufficient data to be collected. Should you and your associates,
however, find the way clear to renexamine sufficient subjects and
controls to extend the study, we could then assist your analysis
with our quantitative techniques, and I am confident that funds can
be found to do 30. Perhaps you will review the possibilities, and
let us know whether and how we may be of assistance.

Separately, I am sending you a few reprints of our work,
including a preliminary draft of the cannabis—EEG report to be
presented in New York next week. These may be of interest to your
neurophysiologiet, and should he wish additional information, we
would be pleased to oblige.

quite stimulated

by

tell

I very much enjoyed and was
the presentation in Washington. Your study

Again, I wish to

you

promises to be one of the finest of chronic cannabis use, and I look
forward to hearing more of it.
‘Hy

best regards,

and

my

apologies for the inconvenience.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>May

13. 1971

Dr. William Tabor
A. H. Robins

1407 Cummings Road
Richmond, Virginia

Door 8111,

have recently completed our pilot EEG study of AHR~1118.
including experiments with single doses up to 350 ng, equivalent
to 4.5 ~ 5.0 ng/kg. We have summarised this data and I am enclosing
a capy for your information and files.
We

we have had difficulty in eliciting a
At these higher dosages, however, sous
changes are prominent and to confirm these, I have undertaken a
direct comparison, on a random assignment double~blind basis of
single doses of ARR 1118 vs. placebo. The dosage selected is
based on body weight, so that we will average 4.0 — 4.3 mg/kg.
The variation is based on the 50 mg size capsule available.

In these experiments,

consistent

EEG

pattern.

This study will be completed in early June at present rate
of examinations.

It

was good to see you

in Atlantic City.
Sincerely yours,
ﬂax Pink, H.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>w Hwy-«M

"V‘r‘" &lt;--

‘Vw

V

May 13 ,

1971

Dr. Jonathan 0. Cole
Boston State Hospital
591 Morton

Street

Boston. Massachusetts 0212‘
Dear Jon,

I am pleased to enclose 3 conies of our report, ”EEG Pcofiles
of Fenfluramine. Amoberbital and Dextroamphetamioe in Normal
Volunteers” for your consideration for Foyohopharmacolagia.
we have actually carried out more analyses with.oimilar
results, so that
the details reported here are a part of our data. Nevertheless,
the figures (6) may be too many and we can reduce these to 3 (1-3 only)
if space is e consideration.
This represents the first of our detailed reports, and I would
be honored to have it appear in Phychopharmaoologia. since without
your encouragement, the program would not have developed.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>May

12, 1971

Dr. Loren Masher
Head, Schizophrenia Research
Clinical ResearCh Branch

National Institute of Mental Health
5454 Wisconsin

Chevy Chase, Maryland 20015

Dear Loren,

It was good to meet you in Washington, and I was pleased to
discuss the lactate studies which Drs. M. Taylor and R. Abrams are
planning in these laboratories. I am enclosing a c0py of our
initial summary, in which we confirmed the observations of Pitts
and McClure.

I hope the

studies in

Denmark

are productive.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>May

Dr. Hanna Grosz

12, 1971

Ap

University of Indiana School of
Medicine

St.
Indianapolis, Indiana
1100 W. Michigan

76207

Dear Hanns,

It

was good

to

meet you in Washington and I enjoyed our
I am enclosing a copy of our letter and

discussions of lactate.

our summary report (unpublished) of our

lactate studies.

Michael Taylor is interested in continuing these studies on
from military service in July. He has proposed to
first test your suggestion of testing the specificity of lactate
ion by repeating the trials with bicarbonate. As you have already
done this study, it would be most helpful for us to read your
report. May I ask you for a preoprint?

his return

The lactate experience is probably non-specific, as you suggest,
but further study, particularly from our frame of reference of
testing new psychoactive drugs, is of interest to us.

I am also enclosing our most recent
of the narcotic antagonists.
My

summary

of our studies

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                  <elementText elementTextId="106293">
                    <text>-,

V,"

—v

,

.

,,,

-.

w .—

77.... r

-.m" -. «mu.» n'a-n.-‘7§,‘A:v~'n‘n§l¢-‘-“.‘vW'IZIA4L'.

is.” nm-numr-w-“um“ v &gt;ww—M‘

May

,-

-‘§’1"twcrn~uMW-W‘A-

~

wow-"me 3..

17;, rpm- Wu,”

12, 1971

Dr. S. Clyde Strickland
Merck Sharp and Dohme
West

Point, Pennsylvania 19486

Dear Clyde,
I am pleased to enclose a draft copy of our interim
Maintenance for
report ”erlpha-Acetylmethadol and Methadone
Opiate Dependence"? dated April 15. We are progressing with
our study, although our more recent dosages are slightly higher.
Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

vars v—r'r-uwm

In

M" .-:

,

M7'W4r;m“wr'

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.

,.

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- m1 .. Wan-WV
w

V.

m.m.r.mw—\-»

.wm— mvv'qv'V‘w

—.

unqmu

“VA-‘1'."

May

12, 1971

Dr. Joseph Hortis
Department of Psychiatry
Meimonidos Medical Center
4802 Tenth Avenue
Brooklyn, New York 11219
Dear

Joe,

to have your Board review our
believe that the content is too clinical and
inadequately quantitative or chemical to be accepted in
While I would be pleased

report

on ECT, I

Biological Payehiatry.
Thank you

for the invitation.
Sincerely yours,
Pink, ”.9.
Professor of Psychiatry

Max
NF

:kt

�</text>
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                    <text>May

12, 1971

Dr. Frederic A. Gibbs

720 North Michigan Ave., Suite 620
Chicago, Illinois 60611

Dear Dr. Gibbs:
I am pleased to have you print my letter of February 26,
in Clinical EZectroencephaZOgraphy. Your journal can make a
significant contribution to the growth of EEG as a science by

critically

that

reviewing the

articles submitted

meet the high standards of a

and publishing those

quantitative science.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1971

�v:

~ ' vv-v—r-ww

--'-.r-‘

'

'

,

. '0 «run-v». vmum-

WWE‘HVF-W'rwtmrmmm"‘4—,-sw“;.-vwmm'W‘W'WWWW

February 26, 1971
Dr. Frederick Gibbs
1427 N.

Chicago,

Astor St.

Illinois

60610

Dear Dr. Gibbs:
Your recent

editorial (Clinical

EEG,

l;

127)

asserts that

"cannabis indica produces no marked or consistent changes in the
EEG" and ”... the changes they [psychotomimetic drugs] produce in
the electrical activity of the cortex are of the same minor order
as are produced by tobacco”. It is difficult to see how you can
arrive at such sweeping conclusions, based on the data printed.
The report by Deliyannakis 33 a1., finds large effects of
cannabis, in a few subjects, with equipﬁent of limited frequency
response. They make no effort at quantification and we have no
idea about the sample size, stability over time, artefact control,
Despite the limitations of equipment and technique,
filtering, etc.
they report large changes, albeit not in every subject.

In numerous studies of the EEG effects of heroin, LSD, major
changes have been observed and related to drug dosage, pre-existing
EEG and clinical effects
(for examples, see Ann. Rev. Pharmacology,
9: 241-258, 1969; Neuropharmacolqu, 9: 539, 1970). Such studies
show that large EEG changes are,common, drug and dose related, and

interestingly related to the behavior of the subject.

Considering the major strides made in quantitative EEG, it does
neither the science of EEG nor clinical practice a service to make such
sweeping assertions as "Let's face it, disordered psychic function,
either spontaneous or drug induced, commonly does not correlate with
major abnormalities in the waking electroencephalogram“.

.

�</text>
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                    <text>May

12, 1971

Dr. Daniel X. Freedman

Chief Editor

Department of Psychiatry,
University of Chicago
950 East 59th Street
Chicago, Illinois 60637

Box

2011

Dear Dan,

RE:

M83

0658 Revised

Thank you for your letter and critique of our ECT study
and Bilateral ECT: Effects on Depression, Memory

”Unilateral

We feund the suggestions cogent
and the Electroencephalogram“.
and we have nade the following changes and revisions.

1. In addition to the multivariate analysis, a description
of the pre« and post-ECT mean depression scores is included.
2.

The

classification of patients into endogenous or reactive
clarified, and reference to our unpublished manuscript

groups has been

deleted.
3.

a

The sources of bias of concern

to the reviewer

(non-random

assignment, non~blind assessment, concurrent drug therapy) are discussed

more

fully in the text,

4. We now clearly
each treatment .

and then noted in the Synapsis~Abstract.

state that each patient

5. The study of Strain gt_§g;,
importance.

is

now

had a grand mal

seizure

accorded a more proper

6. The sections on EEG and on memory are reduced to a few
sentences summarizing work reported elsewhere (Brit. J. Psychiat.,
Die. Harv. Syst. ) .
7.
We

and ask
My

The time

of post-treatment evaluation has been clarified.

would be honored to have
that you reconsider this

this report appear in the Archives
revision.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>May

12, 1971

Dr. Steven Secunda

Depression Section
Clinical Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Dr. Secunda:
With reference

to your letter of April 29,

I

find that the

quotations are accurate, and are not quoted out of context.
may quote these for the Director of the Institute.

You

we have recently presented the results
patients treated with MBCT, and I regret to say

For your information,

of our

first

34

have not achieved a "dramatic" reduction in improvement.
most puzzling and we are continuing our studies to understand why MECT acts like single induced seizures.

that

This

we

is

Our studies clearly support the data that unilateral non-dominant
electrode placement produces clinical improvement in depressive
illness with minimal or no memory deficit, even in elderly patients.

I

trust these

comments

are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

_

-,.

s

.

�</text>
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                    <text>May

12, 1971

Dr. Vincent Dole

Rockefeller University

New

York, New York

Dear Vince,
,"N'ﬂfpw‘m‘wth-w‘

I

am

pleased to enclose a draft copy of our interim

Maintenance for
report “LsAlpha-Acetylmethadol and Methadone
We
15.
dated
are progressing with
April
Opiate Dependence”,
our study, although our more recent dosages are slightly higher.

Sincerely yours,

"WWW"~mw.-ww—mwm

Fink, M.D.
Professor of Psychiatry

Max
7

Mszt

�</text>
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                    <text>1“]
1m,

”nun",

A,-

.Ww—n

A

,.,..,,.-

my 12,

1971

Dr. Harold Meioeles
York State Narcotic Addiction
Control Commission
1855 Broadway
New York, New York 10025
New

Dear Herold,
I am pleased to enclose a draft copy of our interim
report "ZaAlphe-Acetyluethadol and Methadone Maintenance for

Opiate Dependence", dated April 15. We are progressing with
our study, elthough our more recent dosages are slightly higher.
Thank you

for your assistance.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Mex

MF:kt

�</text>
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                    <text>May

12, 1970

Mr. Paul A. Kiefer
Translations Editor
Consultants Bureau/Plenum Press
'

227 West 17th

New

Street

York, New York 10011

Dear Mr. Kiefer:
I have read the translated chapter from Prof. Saarma's book
schizophrenia, with some interest. I also read his own summary,
pp. 164—170. The book reflects the usual Russian approach to
psydhiatric problems, and while he has some data, it is not presented
in fashions we usually understand.
on

The data is interesting, and I believe a translation may
serve to enhance communication. Particularly, if you could
interest one of our Russophiles to write an introductory section
or summary, transliterating the technical terms of the text.
You may wish to consult Dr. Wagner Bridger of the Albert
Einstein College, New York, for his opinion - he is a local
student of these problems.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>m~

.-

m—wnr

May

12, 1971

Dr. Barbara Sonowski, E.D.
Roche Laboratories
Nutley, New Jersey 07110
Dear Barabara,

Again, I want to thank you for the opportunity to
combined drugs at the American Psychiatric

exhibit our study of

Association meetings. The exhibit was well attended,,many questions
were asked-- some cogent and relevant, and some trivial, but all
interesting. Fifty-one visitors requested additional information,
and we distributed more than half (about 700) the reprints provided.
Many

of the

visitors

who asked

questions appeared to

be foreign trained physicians. If it be true that much interest
in combined drug therapy may exist among foreign physicians, perhaps
you would consider exhibiting this presentation at the forthcoming
World Congress of Psychiatry meetings in Mexico City at the end of
November ?

I believe the exhibit will be well received.

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>unnumwm

.

.

_,.

"v

.r.yr~‘w~mw«

May

11, 1971

Dr. Barrett Scoville
Deputy Director

Division of Neuropharmacological
Drug Products

Office of Scientific Evaluation
Bureau

of

Drugs

Rockville, Maryland 20852
Dear Dr.
The

which

Scoville:

RE:

IND

6825

curriculum vitae: of the investigators are enclosed.

is prepared by the MetrOpolitan Hospital pharmacy,
is staffed by licensed pharmacists.
Methadone in solution is obtained from the pharmacy by our

Methadone

nurse. and then kept in a locked wall closet, in a locked room,
until dispensed. Supplies for 2 days at a time only are kept on
the unit.
Urines are collected from patients one at a time by a male

aide (psychiatric assistant).

We are using methadone as a comparison for L—alpha-acetylnethadol;
and the filed protocol is the only operational protocol at present.
At an earlier time, methadone was the standard for cyclazocine and

that protocol was filed with Sterling Winthrop, for submission under
their IND for cyclazocine.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>.
e

.4

“.Ve-nww

ymmv_‘

”v...

May

“ﬁn“

11, 1971

.,
.

Dr. R. Bruce Sloane
Temple University

Health Sciences Center
Department of Psychiatry

Philadelphia, Pennsylvania 19140

Dear Bruce,

is

Sorry for the exchange of reprints. Charlie told Ie that he
narcotic committee at EPPI. Perhaps he would like the

on a

antagonist data.
The ECT

reports are enclosed.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

enc.

�</text>
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                    <text>~

7
v
-

m':

.n'vr'r-v-«cr'

"v“

r-r

nu

May

1w

YWW“W-mrw

Mrs. Lorraine Lasker

Research Administration
York Medical College

New
New

V"

v.

11, 1971

York, New York

—~—-w

Dear Mrs. Lasker:

Mr.

RE:

Comparison

of Accelerated

Convulsive Therapies

I would be grateful if you would respond to the note
Parris regarding our study of BCT.
ECT

remains the principal, effective therapy of psychotic
In comparison to antidepressants, all studies have

depressions.
shown

it

from

to

be more

effective in

outcome and more rapid in onset.

Since 1966, nuptiple treatments under oxygenation have received
special study with good results.
The principal defect in ECT today remains the 5-8
for treatment, particularly in suicidal cases.
.vr

-v’S

‘-

W

“'1'"wa

"172W?“

w‘vwmsmmm'um

ECT

is

an

active treatment at Metr0politan Hospital.

Contrary to the consultant's opinions, ECT is now receiving
additional study because it's efficacy is not duplicated by drugs,
particularly at such centers as Harvard (Drs. Schildkraut and Katy);
Johns Kapkins (A. A. Kurland); Washington University (Eli Robins);
U.C.L.A. (A. Mandell). These scientists are actively involved in
re—assessing ECT and this study is part of the renewed interest.

since 1954; and this project is an effort
It’s relevance to suicide and
I
did
is
Al'hough
depression
high.
not carry on studies in 1962-1968,
I have renewed my studies because the newer techniques offer special
I have

studied

ECT

to answer a public health question.
Wrmw.

.,.’

t

m

m

a.

‘an

.

.

,.—..

'mmwwm

days required

possibilities to reduce hospitalization

and

suicide.

�Mrs. Lasker

~2—

May

11, 1971

In addition, I have been asked to edit a special issue of
"seminars in Psychiatry” (Grune and Stratton) on ECT for February
1972; and

on ECT

to

be consultant

in 1972.

to

NIMH

in an international symposium

are continuing to treat our patients with ECT as the staff
I hepe you can allow these trials of our techniques
so that we can classify the issues of frequency of seizure and
We

recommends.

electrode placement.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

cc:

A. M. Freedman

�</text>
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                    <text>May

11, 1971

Dr. R. Bruce Sloane
Temple University

Health Sciences Center
Department of Psychiatry

Philadelphia, Pennsylvania 19140
Dear Bruce,

is

Sorry for the exchange of

on a

narcotic

antagonist data.
The ECT
.—~.

committee

at

reprints. Charlie told

EPPI.

reports are enclosed.

.31,

Sincerely yours,

.

ru’,ngz.:r;.v

W

41..

Max

Fink, M.D.

Professor of Psychiatry

MF:kt

enc.

me

that

Perhaps he would like the

he

�</text>
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                    <text>m

Wm-tm'lwrv—u .w‘n‘e .m

Awamml/u“ww

E

E
g

May
;

Dr.

C'.

UCB
‘

Giurgea,

10, 1971

M. D.

Brussels, Belgium
Dear Dr. Giurgea,

It

i

be a pleasure to welcome you in New York. during
the week of June 13 to 21. My schedule is quite free that week,
and I expect to be at work in New York. You should select the
day or days best suited for your other visits, and I shall
accommodate my schedule to your needs.

I

will

look forward to your

accommodations
5

to ask.

that

I

may

visit. If there are

arrange for

any
you, please do not hesitate

Sincerely yours,
g

Max

Fink, MD.

Professor of Psychiatry

w.

m5."

�</text>
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                    <text>..

«WU—Ir:

Av

n7,

.

vww-r

-

v.»

-

your

‘m‘w':—’Wm“mwmwvw—u-

w—

ur-

-a

nu— mum—he

mum-w—»-' «mw—m—vrrv , ma»..—

rm

...

no”.

mnw-w-mu-T

um,

Wng-"rﬁos'r

~

dnwr

ran—.222»,

ww'wv-—w

'mav'"

v15?

May

“‘wa

warp.“

4wrvn'w

‘

FWW'V'K-Vrn’rtrwmw'

~

7, 1971

Dr. Allen P. Berger
Chas. Pfizer 5 Co.

Groton , Connecticut
Dear Allen,

letter of May 25, 1970, I indicated that Drs. Simeon,
and
I
Spero
are agreeable to having the reprints of our report,
”A Comparison of Doxepin and Chlordiazepoxide in the Therapy of
Anxiety" distributed to physicians by your professional representa~
On my

tives in the course of their visits to physicians; or in the
course of their replies to inquiries. We indicated that the article
not be used in the usual promotional material or quoted out of
context as a general endorsement of this product.
Dr. Oliver Nikolovski concurs

in this approval.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

n, wanna-mm“..—

�</text>
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                    <text>5—wa- -m— «mv

()

~

"1"num'n

aye-n

May

7. 1971

Dr. Roland Bonsto
George Washington University
1145

Biometric Laboratories
Nineteenth St., N.W., Room 618

Washington, D.C. 20037
Dear Ron,

to enclose a copy of our publication
Interactive Psychiatric Diagnosis Programs".

I an pleased

Aided

"Computer

This represents another approach to the problem of diagnosis,
interactive scope display as a way of communicating
with the couputer. I think it has more precise than the SAID
system presented by Miller 25 31;, at the APA.
and uses the

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kt
one.

cw

�</text>
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                    <text>August 20, 1971
Dr. Gardos
Boston State Hospital
Boston, Mass.
Dear Dr. Gerdos,

In response to your request, I have looked through the
on the high dose-low dose chlorpromazine

files for the report

study. The report was presented in 1967 and the data
sheet is enclosed. There is no summary report as I read the
paper form the slides.
EEG

'

Essentially, the records were collected by Dr. Denier
at Manhattan State Hospital and the tapes were analyzed in Missouri.
72 records were analyzed; and in the initill analyses, there were
no differences in the pre-records, indicating that the sampling

was

adequate.

records showed an increase in theta activity, and
fast frequencies with treatment, but there
use no significant difference in the EEG changes with low or high
The

a decrease in very
dosage.

earlier,

similar to thbse described
that the dosages were adequate. Most

The changes induced were

and indicated

interesting, the changes were already present with the low
dosage regimen and no important differences ensued with the
higher dosages. From these data, we could conclude that the
low dosages were sufficiently high (for these patients) to induce
the neccessary EEG effects, and that higher dosages had no
additional effects.

I tsust these

tapes as soon as they
in extracting

some

comments

arrive,

are useful.

we

will anilyze your

and perhaps we can be of some help

conclusions.

Sincerely yours,
Max

Fink, H.D.

�</text>
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                    <text>August 20, 1971

J. Kuhn
C. H. Boehringer Sohn
Ingelheim, Germany

Dr. F.

Dear Dr. Kuhn,

studies here

have been completed according to the
protocol you completed on July I. The data has been analyzed and
the statistical analyses are now in progress. As soon as these
are completed and the staff has written the summaries, I will
send you a copy. I do not know, as yet, what the data will show.
The

for

viiit

to Ingelheim, I am scheduled to be
in Wﬂrzbnrg from September 23 to the 27, and must be in
Amsterdam on Wednesday evening September 29. I would suggest
we plan to leave wUrzburg so that I can be in Ingelheim on
Tuesday September 28. This will leave Wednesday to make the
travel connections to Amsterdam.
As

my

I very much enjoyed your stay with us and I hope that
you found it regarding. my best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>August 17, 1971
Dr. David Smith, M.D.
321 Crestmont Drive

San Francisco,

California

Dear Dr. Smith,
While I would have no objection to the republication
of my article, "A Rational Therapy of Opiate Dependence: Narcotic
'ﬂntagonists”, the original publication is set for the proceedings
of the international symposium held in Ann Arbor in October. I am
enclosing a copy of that report, and suggest that you write to the
editor of those proceedings, Dr. Chris Zafofenetis at the University
of Michigan, for his approval.
Should he permit, I would ask

necessary footnote that the

etc.

that

you provide the

article is republished, with permission,
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>August 17, 1971
Dear Dr.

Pasic,

I have received the letter of recommendation from my
good friend Dr. Hajnsek, and I welcome your inquiry. Inregret,
however, that I do not have an opportunity to provide residency
training in my Division. I did enquire whether our Department
may have an opening, and find that all openings for 1971-72
are filled.
The préncipal openings of my acquaintance are in
the New Yor State Department of Mental Hygiene hospitals. You
may wish to write to:
Dr. Alan Miller
Commissioner of Mental Hygiene
Albany, Nut York

or

The
may

Dr.

Israel Kesselbrenner

Kirby Manhattan Psychiatric HOSpital
Ward's Island, New York.

first

provide you with general information; the second
have openings as his hospital has recently been separated
may

as a special unit in

New

York City.

You may mention my name

both well.

Good

to either

man, as

I

know them

luck.
Sincerely yours,
Fink, M.D.
laboratory whenever you are in
Max

P.S.

are welcome to visit my
York. I suggest you call a few days in advance (212
369 7900) as I am often out of the city.

You

New

�</text>
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                    <text>August 17, 1971
FADA

36 West 34 Street
New York City 10001

Gentlemen:
While it has been a personal pleasure to be associated
with FADA, I find that my many commitments preclude my continuing
to do justice to much of my interest, and I am.writing, with
reluctance, to resign from the advisory board of EADA. As you
well know, I am very much interested in the treatment of the
many opiate dependent citizens of our nation, and I am sure
that efforts such as that of FADA will eventually provide the
means for the prophylaxis against this dread affliction.
My

best wishes for the success of your efforts.
Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

mf/

�</text>
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.zn-m—xr—ur-w-w

"-7.;

1-

w

w

.w

.

&lt;Q‘,"F“.“I,

July 30, 1971

&lt;

rv‘""'wv‘."'nw“':I,-‘II

Dr. William Cooper

Sterling Winthrop Research Institute

Rensselser,

New

York

Dear Dr. Cooper,

Enclosed are additional case records from our
cyclazocine study program for your files. The top pages
the names of the patients entering and discontinuing the
study since our last report.
Thank you

list

for your cooperation.

Incidentally, I have received indirect reports that
quite successful in investing cyclezocine in a longacting formulation. If true, it would be a useful sdjuvent

you are

to treatment .

Sincerely yours,

th Fink,
mf/

M.D.

�</text>
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mm~mww~u~ wnwwv-n-

,

&gt;

....'

__w .NQ.W..WW_W_ “ v v7w. i,"

_.

V

wwwrw—ww-v—w-w—p—i

—w,r~—

July 23, 1971
Dr. Robert Knights

Carleton University
Ottowa, Canada

Dear Dr. Knights,

Following your letter, I called Donald Cheetham at
Smith, Kline &amp; French Laboratories and recommended he get in
touch with you, when and if, they decide to go ahead with the

evaluation of the

DOB

compound.

I have read your reports and have found them most

esting. I have sent them on to
for her information.
Our

may

my

associate,

inter-

Dr. Rhea Dornbush,

study in Athens seems to be 'off the ground' and

yet fly.

in the studies in Jamaica. Perhaps, on your
next trip through New York, you would have the time to visit
Good luck

with us

?

(212»369-7900).

Sincerely yoursm
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>r

v

-

W' “'~"WIW'.—wmrrmwprwn

.
v-‘WI u r‘:',v
n'vwvww‘ww' use... Irv-”lav.
.V

7

a“

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u warm.wnwwwwm.wwq-r1u. nun.
.

V

.

.

.

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«-

u

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e

n.

u

T. n

.. n . v.7,

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.
.14.:v"

.w-

July 23, 1971

"v“,

r

:rrv-r-wwr-v

-

vvw:

Dr. Jerome

Jaffe

The White House

Washington, D.C.

.J"

Dear
i
'

A

.

Jerry,

John Kramer attended the Aberdeen meetings and during
our discussions requested some information as to the present status
of the development of a long acting silastic-implant for
naloxone or cyclazocine. I am enclosing a progress report on
the present contract, between the College and the Food and
Drug Research Laboratories. The contract ends on October 31,
and we have not been successful in ob—aining continuing support
from the state of New York.
My

best wishes for your success.
Sincerely yours,

E

Max

Fink, M.D.

Professor of Psychiatry
'I—‘—"v"

mf/
anvwww-w-v—vcr-w

...,.v

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�</text>
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                    <text>Tﬂyvy,

July 22,

{Viv—V7.

«ml—m— »..

er...

“my”

1971

Dr. Daniel X. Freedman

Editor, Archives of General Psychiatry
950 East 59 Street
Chicago, 60637

Dear Dan,

submitted our report, "Unilateral
Effects on Depression, Jemory and the
Bilateral
Electroencephalogram" by Abrams, 23 £1, Is it possible to
obtain the recommendations of your editorial board ?

and

Late in April

we

ECT:

many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.

w

v1v7

»

.r...~.;;~

t rr

...

vol,

n» a. m

,

1

~

w

�</text>
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                  <elementText elementTextId="103483">
                    <text>W___

_

~...m~

_

V

‘

‘ _,_

._._.

.

,..,_

,v,

4“,.

,.

,.

,_

,

,

,

.

1,.

“my“ unmanum.

\»-.w.4r~v..-q..yaw,»-New.

.;-

-

,

.

“mi/'lv-Ialr

“any".

war-

3-

vulrgn-vvvlrnuu”

July 22,
Wan'mrvnnrawwr

_

1971

Dear Turan,

I find the report for the Transcultural Symposium very
discussion, I would make two suggestions.

good. In the

data,

Prien

&amp;

Cole, in summarizing the high dose chlorpromazine
suggestions that dosage is a factor in the

make some

treatment of certain scizophrenics, particularly in relation to
age. I believe it would be helpful if their views were referred
to in the discussion.
w

JHW‘”

W!"

”"5""?

W’WW—

'

in"""!""1‘1’7~'"‘7i

‘27

W‘W5W-W7kfd

4r;—

WWWWWWTWWSEFW

During the past few years, there has been some discussion
about 'enzyme inductiog' as an aspect of the metabolism of
drugs which may affect the efficacy of drugs in some patients.
Prior experience with drugs permits the tissues to learn how
to metabolize or how to adapt to high tissue levels of the
most toxic agents. A good example is the development of tolerance

to opiate and hallucinogenic drugs. This, too, may be a useful
aspect of the discussion, particularly since it provides an
alternate explanation to the genetic hypothesis.

I have just returned from Athens, where I found the
study progressing very well. The initial case~finding phase
should be completed by the end of the summer, and I hope
to spend a few weeks in the actual examinations after the
WUrzburg meetings.
I trust you will enjoy the second half of your sabbatical,
and should you have the occasion to step in New York en route,
my home is open and your welcome is always assured. My best to
Ellen.

WWW"?

5;

Sincerely yours,

0'.

mm

"are

:
WWWM

Max

Fink, M.D.

�</text>
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                  <elementText elementTextId="106309">
                    <text>r.“ wx-n-c-Wrnvm

~mmrw-mwm- rm

n

W‘wm'vﬁv-v'm‘r-

J wmanmwuxmm

,

"nu--

-

,

,

,

'"W'\tvv~&lt;- .—v..mi—..-w-.~.-

...—..,.,._..m~_r....r_..

W,

-v
_

..

.

v

V.’

-.

,-

w

w."

,WWFrymw.—uwmn

tar-vmmrrww-

July 22, 1971

u-w-n—v-

vr-v

mum—mum”

Dr. Jonathan 0. Cole
Managing Editor

Psychopharmacologia

m.

W,"

uwmwﬂw

.

V-A'Wi-WMWIVV'F‘WWW-

Dear Jon,
With reference to manuscript A—785, 'EFG Profiles of
Fenfluramine, Amobarbital and Dextroamphetamine in Normal
Volunteers', I would suggest the following key words:

EEG,Quantitative
Fenfluramine
Drug

Classification

Volunteers

Amobarbital

Dextroamphetamine

W"W"E’ﬂmv«m‘mm‘wm¢r'

My

thanks for your consideration of

this report.

Sincerely yours,
Max

Fink,

M.D.

was

ww’rrr'

m—

Iwm maazww P‘W-WWK

7.an

�</text>
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‘

‘

-r—vmw...

‘

,w...

“an"...dwnv “ov—w—w‘rv v.»-

‘~»&gt;

v.

w-w

«;

.—

-".’-r“"\"

212-369 7900 x245

July 22, 1971
ﬂoorge E. McCarthy, Librarian

WWW

Ciba—Geigy Corp.
Ardsley, New York 10502

¢
rwr

wan-n3

Dear ﬁr. ﬂcCarthy,

wzfsw

1w

mgr

We

mm—

.‘K‘I’Z-‘&gt;'xrr17~r»

v

to

me

Your purchase order 1218 of June 30 was ﬂoruarded

for reply.

'

request is out of print. We have,
continued
our work in the development of a quantitative
however,
The volume you

method for the classification of new psychoactive drugs,
and I would be pleased to discuss this program and make the

EEG

appropriate reprints available to your scientist requesting
the volume.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

.W

.‘
“S

~19!”va

_

�</text>
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~

"
A

Alummwv

/

rum-1

n
-

A»

,‘Hx'n'filul‘ct'r'r'w

w‘

July 22,

www.-

an

1971

me

vww-w—pv

Dr. Stuart Lewis
Royal Edinburgh Hospital

Edinburgh, Scotland

w

"mmmtmvva

Dear Dr. Sewis,

r"
-

”,3:er

AWN-Yrmww

.11:

:-

(my-n4

I want to take this opportunity to thank you for your
patience and courtesy during my recent visit, which was a highlight
of my trip. I am impressed with the amount and variety of
work of the Department and particularly with your enterprise
in the study of heroin and cannabis.

1pc-

mart:

«Wm.

~

w

“TL-mu

7mm

Incidentally, I did arrive at Anderson's in time
helpful. Thank you for the suggestion.

My best regards to your associates, and I look forward
to continuing our discussions in Wﬂrzburg.

'5":

,

merry

:r'

uz;

Sincerely yours,

m,

2,1:

Jun

mg"

-

Max

Fink,

5'
'1‘

..

4!:-

“7"”.

..

.-

é
-.,~nvw~a—~.

and

they were most

l'ioDo

�</text>
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~9"'?‘—"xi'

‘
'

May

30, 1971

Dr. Ian Oswald

Department of Psychological Medicine
University of Edinburgh
Scotland
Dear Ian,

I am planning to attend the narcotic antagonist meetings
in Aberdeen on July 12-13, and for two separate reasons would like
to visit your laboratories on either July 14 or 15. Is either date
available for you ? If not, I will be in London the week before,
and should be in Edinburgh, en route Aberdeen on Saturday, July 10.
Is this date feasible ?
In addition to visiting your laboratories to discuss your
varied drug studies, we have a special commission to look inch
the use of heriin in Great Britain, and it may be helpful to meet
those of your colleagues (Dr. Lewis ?) who have experience with this
As our mission is to survey the experience in your country
drug.
prior to undertaking a heroin delivery scheme here, perhaps there
are others in your city who may be of help. If so, I would be grateful
for your recommendations.

many and

2*
g

Is

it

My

thanks.

possible to

visit July

14

or

15 ?

Sincerely yours,
Max
New York Medical
5 East 102

New
USA

Street

York City,

NY

College
10029

Fink,

M.D.

�</text>
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                    <text>v:

x

r
4

a.

,«Aymr

:v
1.v

.uwwww

July 22, 1971

awnwuzzggauuu

Prof. Alfred
-»a1¢uuwrgnzm«

u?

Chairman

M.

Freedman

Department of Psychiatry
New York Medical College

«tr:

4-14.”

Dear Al,

Re: Rhea Dornbush, Ph.D.

n-.~_.menw-re

.vm

«

raw/«mt

«truism

erﬂ'ﬁmiwﬂ‘r

3:

Dr. Rhea Dornbush has done an exemplary job in all
her assignments during her tenure in the Department since
1968, that I am pleased to recommend her promotion to
AAAou'au Paaﬁuzs M.

Since joining our faculty in 1968, she has described
the memory effects of unilateral and bilateral electroconvulsive
therapy; the effects of acute cannabis inhalation on mood and
performance tasks; developed the chronic cannabis study
program, assuming all the responsibility initially assumed
by Prof. Stanley Feldstein; and has established the liaison
with some of our overseas collaborators.

I have found her knowledgeable, responsive, responsible,
excellent co—worker, and recommend her promotion
without reservation.
and an

0.

:

Sincerely yours,

-;

«tw-vv.»

r
r"

Max

WSWVK~

Fink, M.D.

Professor

m.

"HF,

Director, Div. Biological
Psychiatry

mf/

�</text>
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                    <text>,~"."~&lt;. Jung-.5.“

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My

21.,

mm

Dr. Clinton Brown
Maryland Psychiatric Research Center
Baltimore, Maryland
Dear

Clint,
I have 'read' the record of

Rosemary 0"Connor. From the
13 in common; and channels 4 &amp; 6 have derivation 14 in common. These are sites which
may selectively reflect muscle activity from the masseter
muscles (jaw clenching) and this is the most likely source
of the very fast activity in these channels. Channels 2 and 5
may not reflect this activity and I know of no reason why
one should assume that this activity is present but 'hidden'.

montage, channels

1

&amp;

3

have the

derivation

I believe the record is 'readable' (unless these two
channels are selectively filtered).
In our studies, we like to obtain 14—16 20—second epochs
but have accepted as few as 10—12. If the record is short or
poor, we try to re-analyze using lS—second or 10—second
epochs.

Good luck

!

Sincerely yours,
ﬂax

w...

.

Fink,

M.D.

�</text>
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~.

was”

.,,,~

V."

ly'w)’_:.n‘ em. .

w"

T.

.

.V... pm—.

V...“—

,“_m_,_,

:‘mrlc&lt;.u

. ,. ..~a—.

.......e...

Wyn—w."

July 20, 1971
Dr. Richard Hollins, Ph.D.

University of Oregon
Eugene, Oregon
Dear Dr.

Hollins,

Cyclazocine is the compound which has the most application

are more interested in 'pure' antagonists like
Cyclazocine is not in short supply,
but the other compounds are, as they are derived from thebaine
which is a compound on a government proscribed list.
Any efforts that can be xpended to improve the synthesis of
today, but

we

naloxone and

M—SOSO.

naloxone should be helpful.

a,
.v
v.

“Wiwﬂ'

efforts at increasing the duration
compounds
in man. The principal shortcoming
these
of
of action
of
the
antagonists is their short
of the therapeutic use
we
and
to have a formulation that
were
duration of action,
would be effective for 30 or more days, the clinical problems
of opiate depnendence would be easier to treat.
I would suggest you contact Prof. Paul Blachly at the
University of Oregon School of Medicine, as your most local
authority in opiate dependence. He has an extensive experience
in addiction research and a keen understanding of the role of
the antagonists.
Equally important are

Good

luck.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

,4-

v
3-.

V.

�</text>
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                    <text>July 20, 1971
Dear Ernie,

progress has been steady with the Seminars, and
the only handicap is the summer holidays and the fact that
my secretary has joined her husband in Texas.
The

Four reports are in; two more are promised by the end
of the month; some of the Q&amp;A are in, and others have yet
to be completed. I plan to have my editing done during the
first few weeks of August, and the reports will be retyped
by my secretary in Texas. This may cause some delay but her
accuracy and judgment are indispendable to me.
what

I

There are two hold-outs as of today, and I shall see
can do

this

week.

I will send you

some

manuscripts by

mid—August, and

remainder should meet an early September deadline. Should
you wish to edit the texts then, I would be grateful.
My

thanks for your regards.

Sincerely yours,
x."

min

.7:

Max

'1';

:1

'1.va

w

.

Fink,M.D.

the

�</text>
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                    <text>5”,,“

7

_

ﬂ

gm

,

may». "m'w-w

up" Vwﬁm-r"w:7lmvwl wv'wﬁ'w'vwmwmrwwa/IF‘L'KT‘

July 20,
Br. Christian Spahr,
Lea

Febiger
Philadelphia
&amp;

1971

Jr.

Dear Mr. Spahr,

for your kind offer.

Thank you

My

selections are:

Everett: Functional Neuroanatomy
Grollman
“1

«I11!

&lt;

—n,.,,-w

x-wu-

v
2'

r

&amp;

Grollman: Pharmacology

In the event you are interested in publishing an
unusually fine symposium on drug abuse, the British
Pharmacological Society has just held a symposium on
"Narcotic Agonists and Antagonists" in Aberdeen, Scotland.
The chairman of the program group, Dr. H. w. Kosterlitz,
is seeking to publish the manuscripts. He can be reached
at the University of Aberdeen, Fosterhill, Aberdeen, Scotland.
)

nw’n'1‘

Sincerely yours,
1"‘Io'11d'l'1‘w

‘

mmvmu'mrc-r

Max

Fink, M.D.

1' —;~'. -- w,~.a4.v,»~.~uv-.

»

~-

u”

w,

.w—w,

.. m...—

�</text>
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.

a;

EM

w—nv

_

July 20, 1971
Dear Mrs. Hyatt,
Thank you for your kind

offer, which I gladly accept.
the opportunity to participate in the process
of editing books, but found my time inordinately tied up
in the process. You must know that many publishers are
now actively seeking volumes on drugs of abuse, and since the
authors are for the most part inexperienced and unknown, they
send their texts to some of the better known investigators.
I

do enjoy

My

selections:

Barlow: Contemporary Brain Research in China
306—10844-5

Wulfsohn-Sances:The Nervous System and Electric Currents
306—30478—3

Kissin—Begleiter: Biology of Alcoholism
306-37111-1
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

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                    <text>July 9, 1971
Dr. William H. MhGlothlin, Ph.D.

University of California,
Department of Psychology
Lon Angelaa,

California

Loo Angolas

90024

Dear Dr. MoGlothlin:

reports of our various studies of cannabis are enclosed.
Our three ongoing studies, that of acute trials of marijuana in
volunteers, chronic marijuana trials in voluntaora, and tho
central affects of haahiah uaa in Graaca, era in tho data collection
phase and should be ready for publication late this fall.
The

Sincerely yours,
Fink, 24.1).
Profaaaor of Psychiatry

Max

MF:kt

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Br. Jack Hehor
Mental Health Materials Center, Inc.
419 Park Avenue South
New

York, New York 10016

Dear Mr. ﬁsher:

associate, Richard Abrams and I have read your invitation
believa we can assist you in your mission. As I will be away
much of the amour, Dr. Abrams is willing to work with you and I
and

Hy

suggest you reach him at 360-6746.

Sincerely yours,
Fink, Mm.
Professor of Psychiatry

mu:

�</text>
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                    <text>.

I.

TO:
FROM:

B. Schwartz

DATE:

July 9, 1971

Mu Pink, “.11.

SUDJECTé

Division Coverage

I will be

away

July

10

July

—

23

(approximately) on the

following visits?
July 12-13

In

Aberdeen

Narcotic Antagonists

14

Edinburgh

Opiates

15~21

Athens

Marijuana Study

absence, Dr. lake is responsible for the addiction
programs,
Dr. Abrams, the Kirby and Met~ECT—psychopharmacology
and
my

programs,

Dr. Volavka, the programs

MF:kt

at

5

East 102nd Street.

�</text>
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                    <text>July 9, 1971
Mrs. Carol Hyatt, Editor
Plenum Publishing Corporation
227 West 17th Street
New York, New York 10011
Dear Mrs. Hyatt:

There is a plethora of books about addiction. I have reviewed
the questions you pose and find little justification for the
special publication of these data outside the usual routes (journals).
Dr. Lal

is not

to me. Indeed, most of the participants
(except for 1, Z, 10, 11, 25, 29, 44, 55) are not known to me.
known

the ten papers cited, I am sure the data of (1) has been
published; (2) is a review from an administrative office in Washington
[Brande]; and the others are unknown. 0f the other reports, the only
one I would probably find of interest is 25 (Oswald).
Of

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt

P.S.

I seem to be answering inquiries from Plenum so frequently,
I feel like a member of your staff. Cut it out or offer me

an appointment and

retainer.

�</text>
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                    <text>July 9,
Dr.

EEG

1971

Peter Kellaway, Editor

Journal

Baylor College of Medicine
Houston, Texas 77025
Dear

Peter,

pleased to enclose our report “EEG and Clinical Change
and Unilateral Electroconvulsive Therapy" for your
consideration for the EEG Journal.
I

am

after Bilateral

EEG changes and their relation to behavior
interest to clinicians for more than 20 years, This
study contributes some novel data, namely the differential asymmetry
with different electrode locations, and discusses the problems of
using rating scales as behavioral measures in studies with EEG. In
order to make the work of your reviewers easier, I am including couies
of our last report dealing with this subject.

The

issues of

have been of

Thank you

for your consideration.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>July 8, 1971
Ur. William Guy

The George Nashington

University

Bio-attic Laboratory

1145 ﬂinotosnth

St.,

N.W., Room 618

Washington, 13.0. 20636
Dear

Bill,

Enclosed are 3 RPR's for our ongoing studies of heroin
(discotylmorphinc), mothsdone, l-alpha—acetylmcthadol, and
cannabis.
The chemical formulae of two compounds you requested
U 28774 is related to diazepam and is
a d1 tscenic mixture of one of its analogs.

are not available.

OI~63 is a peptide derived from the analysis of complex
proteins. It is a pure crystalline substance but I do not
have its formula. My guess is that it could go into 506 or

505.

Sinceroly yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="106317">
                    <text>IR. Echvtrtl

T0:

PM:

M15:

staining in a:

1971

buoyant“

LN. hu burn “had by Dr. Hanna
«ch «7 u: mtmolitm Kupiul. Since
bun working both at Kirby and mtropontm it. 1. Manama

mum
Much,
and

to sign in

she has

July 8,

Pink, hid).

Max

SUBJECT:

DmTE:

out

Miss Durbin had bean signing for but
she
to Kirby, but. this is mmpnblc.
was
assigncd
the
days
on
would it be possible to «Intact have hot sign weakly, or no: sign

for he: to accomplish this.

at all?

Thank you.

arm:
cc: Dr.

Katalin

.

.a:

Li

�</text>
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                    <text>July 8, 1971
Dr. Carl Chambers

Division of Research
New York State Narcotic Addiction
Control Commission
1855 Broadway

New

York,

New

York 10023

Dear Dr. Chambers;

I found your report on "Differential Drug Use" most
interesting and useful. I an puszlad, however, by the absence
of alcohol from the inquiry and the various tables. Does this
omission reflect our general acceptance of alcohol as a "nondrug”?

In the report in the New York Times, some conclusions about
drug abuse were reached, and in the absence of comparisons with
alcohol abuse, they were of less censequence than if they were
compared to alcohol.
Perhaps in the next review, alcohol use can be used as a

standard.
you

It is, nevertheless,
for sending

it

to

me.

a fine and useful study and I thank

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

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                    <text>July 6, 1971
Dr. Jonathan U. Cole

Boston State dospitel
Boston, Massachusetts
Dear Jon,
Don Shapiro and I have reviewed the comments on our report,
“EEG Profiles of Fenfluraninc, Amobarbital and Dextroamphetsmine

in Normal Volunteers“ (Ar785), and thank you for them.
The figures do represent our data as well as we have found,
but the reviewer may be correct in asking that the ordinate be

clarified.
be

better

Would "Standard Score Based on Pre~Drug Mean and Sigma"
than “Difference from Pre~Medicstion Mean”? If this is

better, the printer

can change these

in the glossy prints in the

will have the figures remcaptioned.

original; or, we
I believe Table 11 does show something better than the text,
and I would like it published.
"Your comments on page 5 are most helpful. We have rewritten
the paragraph, and have inserted a corrected page 5.
The second reviewer asked about order effects for fenflursmins
when it was introduced st.the end of the series in some subjects.
We examined our data for order e~fects and found none for drugs, but
did for differences in the first records from subsequent records
(pg. 7). The first session effect (similar to the first night
effect in sleep EEG research) was accounted for, however, by the
random drug assignment.

of female subjects was a problem. we found that the
women (due to the
variability of prs~drug records was higher in and
male
this observation
subjects,
menstrual cycle?) then in our
of child
woman
in
plus our reluctance to use experimental drugs
experiment.
since
this
males
only
bearing age has led to our use of
some
BBC
by
sex
except
differencss
We do not have any data on
adequate
and
not
is
this
suggestions that females are more variable,
Our use

for publication.

�“v.1:

m...“

v

“we-"

A—

pnmw‘xw‘m—r.

—.'

'n'l"

WW

w'l‘w—m

1
www—

w

"—I-v—wvm-w-w-r

r...

.__..,—yv

-2-

Dr. Cole

Finally, the

speculation and

I thank

you

mechanism of

July 6, 1971

action of fenfluramine is

is of great interest.
for your

support of our programs.

prompt

consideration,

and

for your continued

Please advise as to the figures.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
enc .

a matter of

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                  <elementText elementTextId="106319">
                    <text>July 6, 1971
Dr. Gilbert Kayne
Merck, Sharp 8 Dohme
wast Point, Paunsylvania 19486
Dear

Gil,

Enclosed are two articles from the book “Narcotic Drugs
Biochemical Pharmacology”, edited by Dorothy Clone: and publiahed
by Plenum.

Have a

nice

summer!

Sincctgly yours,
Max

Fink, “.0.

Professor of Psychiatry

�</text>
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                    <text>mar—VW'WRIW“

July 2,
Dr. Jerome

3-}.

1971

Jaffe

Special Counsultent
to the President

The White House

Hashington, B.C.
Dear

will

Jerry,
The grapevine has you

be

off for

Viet~Nam, an&amp; I

trust

your

trip

helpful in clarifying the facts of drug abuse along our

servicemen and

their dependents.

called earlier this

week, and I freely shared our data
£150 sent him a copy of the program of the looting on
narcotic antagonists to be held in Aberdeen, July 12-13, and a copy
of a small project to get studies of M-soso off the ground.
Roger

with him.

1

It is apparent that neither

NIHH, BEBE, ”AS/NRC,

nor industry

have provided the leadership to develop the antagonists. I believe
the appointment of either I committee or an ”office* for this
dovelopment would be a necessary first step. New York City mas
established such a committee but included no one with dedication

or interest and
A.

it is

ineffectual.

In answer to your questions, the projects that are important
(1) Testing cyclazocine prophylaxis in Viet-Ncm, using

available oral doses of

2~4

ng/day,

coubined with.naloxonc during the
(2)

a

rapid induction schedule,

first

Develop u long acting

week.

antagonist.

(a) Contracts for trials with naloxone, using
such methods as depotaoil, silastic, plastic film;

this

(b)

Change import quotas fOr

(c)

Trials for

thebeine and import

other raw materials for naloxone; and, establish
supply of naloxone for clinical research.
and

u long

an adequate

acting cyclazocine.

�—~e:an‘-m-MWWW

Jaffe

Dr.

-2-

July 2,

1971

unn-

"
‘vvf

iv

Test and establish the pharmacology, clinical toxicology

(3)

~—

clinical trials with

and

useful, introduce

it

M—SOSO

and

into trials of

EN

If either

1639A.

compound

a long acting formulation.

is

(4) Clinical trials of cyclarocine or naloxone in direct
comparison with methadone or l—alpha~acetylmethadol.
B.

The

"guesstimate" costs for the projects,

on a

"crash" basis:

(I) frophyl§§i§_- for consulting expenses US-VietNam, 4—6
$10,000; local military costs; supplies to be defined
staff
by Sterling~Winthr0p based on size of study.
members

(2)

—

Long

acting development

(lst year).

$800,000 (4 contracts

Naloxone

Thebaine and naloxone supplies $250,000
Cyclazocine

status of

(3)

M—5050

Pharmacology

1639A,

but for

M-SOSO:

and

EN

Animal pharmacology

Clinical trials
Supplies

.m—

:

6

VA

(4)

clinics,

Clinical

600

added to present
C.

Role

If

1639.

I do

?

not

9

$200,000)

know

the

$42,000
120,000

50,000

Comparison Cyclazocine-Methadone:
$200,000 organization cost

patients, additional

VA

allocations of $400,000/unit.

for myself.
you

establish

a commission, I suggest you consider
F. Blane or K. W. Bentley
I would be pleased to be

J. Villareal, D. Jasinski, G.
(Great Britain), J. Woods and A. Kurland.

A.

Freedman,

a member or to chair

it.

I have been actively soliciting the cooperation from industry
a few years and now know many of the people who could be involved
in a long acting drug research program. If a committee were set up
and given the support its studies justified, the programs would be
successful in a reasonable time. They may require some special
regulations regarding financial rights to industry, however, and some
cooperation from BNDD.

for

,

�&lt;_:-v..-

"1"”

.

Dr.

Jaffe

-1-

July 2,

1971

Should you wish to undertake this program yourself, or have
Roger, John or someone else do it, I will make my files available
and introduce your appointee to the appropriate persons.

Incidentally, Villareal and Kosterlitz are chairing a symposium
the antagonists in Aberdeen, July 12~13 and you may wish to attend
or send someone. I sent Roger a copy of the program in case you had
not seen it.
on

Again,

my

best wishes for the rapid success of your mission.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 1, 1971
General Plinting Office
Washington, D.C.
Gontlcncn:
Kindly send us 100 copies of
GPO-1034A
We

hold contract

Public Voucher for Purchases
and Services Other than Personnel.

HSM~42—70—98.

Thank you.

Sincerely yours,
Fink, M.D.
Executive Director

Max

Mszt

�</text>
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                    <text>July 1, 1971
Dr. Henry

Brill

Pilgrim State Hospital

Brentwood, New York
Dear Henry,

I am pleased to enclose a summary of my report of my visit
to the University of the West Indies, and my letter to Dr. Beaubrun,
suggesting a collaborative study in the winter of 1972.
Should he concur in the recommendations, I should like to
the Marijuana Commission for support, particularly if
may be useful to do the study promptly.

call

it

on

I told Dr. Beeubrun of your interest in cannabis research,
and your central role in our study in Athens. and he expressed
an interest in meeting you in Jamaica this winter.
my

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Pnychiatry

�</text>
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                    <text>October 31, 1971
Dr. U.

J. Jovanovic

Universitats-Hervenklinik u. Poliklinik

Fuchsleinstrasse 15

87 Wurxburg, Germany

Dear Dr. Jovanovic,
symposium,

to

New

York

Enclosed

is a copy of my presentation at the recent
of Sleep". I regret the delay but I did not return

"The Nature

until

mid October.

very much enjoyed the meeting, and wcmt to take this
I
to
opportunity
congratulate you on a fine meeting, well organised and
well run. Most interesting for me, was the occasion to meet many of your
co—workers and to realize that in a few years you have created a most
productive research group. I look forward to the results of your labors
in the scientific press with interest and optimism.
My

best regards, and

my

thanks

for your kind invitation.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

�</text>
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                    <text>EdiTor,

OcTober
JAMA

3i, |97i

American Medical AssociaTion

Chicago,

illinois

Sir:
i am
wriTing in reference To The reporT by The AMA Council
on MenTal HealTh, "NarcoTics and Medical PracTice" in The issue of
OcTober 25. While The reporT repeaTs The convenTionai expressions of
earlier reporTs, There are Two faceTs of The TreaTmenT of oplaTe
dependence of The meophine Type ThaT are presenTed so poorly as To
warranT commenT.

AfTer agreeing ThaT meThadone mainTenance is a logical

procedure for communiTy agencies, The CommiTTee recommends This
TreaTmenT as noT feasible for office prachce, noTing ThaT The individual
physician ". . . cannoT provide all of The services for The various
TherapeuTic needs of The paTienT." As i know of no evidence ThaT
meThadone mainTenance is therapeutic, nor of any evidence ThaT some
'TherapeuTic services' affecT The course of The disorder in subjecTs
receiving meThadone as Their primary TreaTmenT. Could iT be, ThaT The
Council is once again presenTing ex cathedra opinions based on no
evidence, To suiy some public needs or prejudices ? Would iT noT
be more honesT To suggesT ThaT The fear of illiciT disTribuTion of
meThadone puTs The AMA Council on The side of limiTed disTrlbuTion,
and if ways could be found To use physicians wiThouT seepage, ThaT
This would be as saTisfacTory as any oTher means of dlsTribuTion
ThaT provided medlcaTlon wiThouT seepage ?
A second issue is ThaT The secTion on research repeaTs The
sTaTemenTs of years pasT, wlThouT acknowledgemenT ThaT some progress
has been made in Two areas- The use of narcoTic anTagonisTs of The
specific Type (see JAMA, 202:l9l—l94, i967; ibid, 215:2l08-2ll0,i97i;
Science, 169: i005-l006, l970) and in The conTagbous Theory of opiaTe
dependence— The laTTer providing an alTernaTe Theory To The convenTionai
'bad psyche' Theory implied in The CommlTTee's recommendaTions.

There are oTher discrepancies wiTh experience which suggesT
ThaT The Council has noT Taken lTs charge seriously.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry

�</text>
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                    <text>chober 30, l97l
Dear Turan,
The enclosed leffer senf me lo my basembnl flles, and
have pulled dupllcafe coples of every reporf durlng +he
halcyon days of MlP's collaboraflon-- and I am sendlng these
10 you separafely. I fall, however, To flnd fhe repor+ requested
ln fhe enclosed lefler, whlch ls who? sent me to my flles ln The
flrsf place. And, lhe EEG manual by Shaplro -- l have one lasf, flle
copy. Perhaps Thls Issue should be redone and republished.
l

By now you
My

besl

To

could be back. Trusf

all ls well.

Ellen.
Slncerely yours,

�</text>
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              <elementText elementTextId="49943">
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                    <text>WW7

mgr

Iww"

a,

we.

r

-

n1

M-‘r-w

w-xm

r

w‘-"

.

*V

mm "

_

,

W‘mewm‘w wm}vmwﬁwpw

yam—n.”

-u——r—..-v.,r-m. - www.mywvwﬂ‘ww.

-95."..wgw

October 28, 1971
Ron. Paul Rogers, M.C.

U.S. Congress
Washington, D.C.

Ref: A&amp;C-3—1-Drugs

Dear Congressman Rogers,
You were kind to answer my letter so optimistically,
have
I
no experience in suggesting legislation, I have
tried to outline the form that seems to me, to serve the needs.
The commission idea comes from the potential power of focussing the
energies of a group of members on 3 defined problem-- not one so broad,
that the number of options are great and the funds diverted to
provide representation of all points of view. This, in my mind, is
the potential flaw with the President's view of drug abuse control—
no man is so equipped by training or experience to lead the field in

and while

prevention, detention, military problems, education, 355.

Furthermore, you will be pleased to know, that in
the
repeated admoiishment from your office and from the
response to
academic segment of our society, two important steps have been taken
in regard to the antagonists: naloxone has been invested in a
silastic implant, and is now in animal trial in New York; and naloxone
pamoate has been produced, found safe in dogs, and is soon to go into
human trial for duration and efficacy tests in our laboratory. In
addition, there is another, potentially more potent antagonist, which
is now in human toxicity trials (BC 26OS—Bristol); and the first trials
of lealpha-acetylmethadol show a three times a week schedule to be

safe,

and as

effective as high dose, daily

methadone

in addicts.

Perhaps, the commission will come at a time when it
can reap the harvest of these early plantings, but there is so much
to be done that I still feel a specific body with a specific charge
may be appropriate now.

I shall be pleased to

suggestions at your convenience.

come

to Washington to discuss these
Sincerely yours,
Max

Fink , M.D.

Professor of Psychiatry

7.

-mv

w. .1.“ -w. "we" . .

.

”H,“

�</text>
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                    <text>October 28, 1971
Dr. William C. Bunney

National Institute of Mental Health
Rockville, Maryland

Dear Bif,

I very much regret not being able to fly down today. It
is
first time I was grounded commercially in years, and I found
the experience most frustrating.
the

Had I been there, I would have told of the availability of
the naloxone pamoate, which apparently has been offered by Endo to
our laboratories for study; and the tests that should be done with BC
2605 of Bristol; as well as the new findings with l—alpha acetylmethadol.
The latter study is completed and as soon as the report is retyped, I

will send
forms

you a copy.

I am returning the travel request
for your files.

and other

official

Separately, also, I am sending ypu a copy of the
revised proposal for studies in Greece of chronic cannabis users.
Needless to say, I will c00perate with your program for
other treatments of opiate dependence—- I hope more successfully than
in attending this meeting.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="103496">
                    <text>wwwv-

.

W...» _..

.07.,‘w—rn .

,

v

_”a

in.

l

,

.

,

vw-wn—wm

,

‘

a...

,

‘

.w—

"V-‘avlv...

,

111W

.—

“.mp

s...

m~wwu—-vm~_w——W

October 25, 1971
Dr. H.

M.

van Praag

University Clinic
University of Groningen
Groningen, Netherlands
Dear Dr. van Praag,

Enclosed is the report on the present status of
research into the problem of opiate dependence, from the point of
view of theories and practice of biological therapies. If the
message is too long, feel free to delete any section that may

interest

you

least,

The

report

on cannabis

and should be out by Wednesday.
on a

Again,

fine program.

my

psychosis is

now

at the typist

thanks for your invitation and congratulations

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

"Kl-"V." w-vr-w—W“. "xv—umvm awn

�</text>
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                    <text>l

m... .............——w

v"...

'|"'\“

,

' pm.

v

.-

~

‘1..."

...

“V""""'—""'we «cum—wwv-‘mwmy_,

M'n’v-w"

"“1

.m:

FMWW.

“1....

Mr. Arie de Kool

J.

Martens
Natuur en Techniek

Th.

M.

Heerien, Netherlands
Gentlemen:
honored by your kind invitation to participate
in a symposium on drugs of abuse, and should be pleased to write
the article you request on the problem of the opiates. it should be
feasible to describe the social issues in opiate use, the clinical
pharmacology, physiological effects, and present modes of treatment
and prevention. You should be aware that our approach to treatment is
I

am

conventional principles of medical
treatment and not relying on simplistic social approaches.

idiosyncratic, being based

on

The main problem in accepting the assignment Is the time
to carry lt out, for I am heavily committed during the next two months
and would not be able to begin before the end of the year. if a delivery

date about February

for

As

i

my

is acceptable,

it

other suggestion,

is possible.
i

am

particularly interested

in the role of brain function in the treatment of mental illnesses.
Using the EEG, particularly in highly sophisticated quantitative analyses,
we have determined that the mode of action of psychotropic drugs lies
in their effects on the brain, and hence on the changes in brain function
(EEG) that they excite. Most of the psychotropic drugs have unique
EEG 'signatures', and these identification
marks have been useful to

sending you a few of our recent reprints. it is
my belief that this material lends itself to a popular presentation,
and perhaps i could, if you agree, try such a description at the time

us. Separately,
I

i

am

prepare the opiate report.
My

completion

may

thanks for your invitation, and
be within your schedule.

i

trust the date for

Sincerely yours,

i
E

Max

E

l
r

l
i

Fink,

M.D.

Professor of Psychiatry

i

r

V

October 25, l97l

i

i

.w—w

Send

letters to:

P.0. Box 269
Great Neck, New York ll022
U.S.A.

WWW-“WW plan-w:

�</text>
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                    <text>”.manrm

Mr.
New

V...

Mr. W...

.mm

Jerry Finkelstein

warrw

was"... 1-...

.,w~»-wwm.vw

M...

"We“.w—‘v

inn—”.7

.

VWIVw—www—waw"

—w-F

October 24, 1971

York Law Journal

258 Broadway

New

York 10007

Dear Mr.

Finkelstein,

I recall clearly your article in the New York Times
total response to the drug abuse epidemic, and am
heartened by your announcement today that the New York Law diurnal
is planning asspecial issue devoted to the drug problem.

calling for

a

Beginning in 1966, we have been investigating the
of
using narcotic antagonists in the treatment and the
possibility
prophylaxis of ipiate dependence. We have been successful in demon~
strating that two antagonists, naloxone and cyclazocine, are effective
in blocking opiate use in man; and in beginning the work needed to
develop a long-lasting delivery system.
There have been many problems in this approach, most
noteworthy being the shortage of drugs for testing. In June, 1970,
in conjunction with the National Institute of Mental Health, we
arranged a meeting of the principal scientists working with these
drugs, and the conclusions of that meeting included the recommendation that further study was warranted. A summary of those proceedings
is published in Science, 192:1005-1006, 1970.
In the past few months, important steps have been
taken by researchers to clarify the role of these drugs and to
extend the number of institutions capable of testing these compounds.
In an issue projected for publication, it would be
valuable to have a sober statement of the data available, and the
projected uses of these interesting agents. I would suggest that
you reach the chairman of the Department of Psychiatry, Alfred M.
Freedman, should you wish a more sober and optimistic appraisal than
that usually emanating from official sources in the nationss capitol.
In addition, I would urge you to review the latest
information on the limitations of methadone, and the possible
advantages of a long acting derivative, l—alpha-acetylmethadol.

Sincerely yours,
Fink, M.D.
Ptofessor of Psychiatry

Max

m-vuvw—U—Cu

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                    <text>w—u—qu—p.‘w‘V-uvw—v$wa~yrﬂmuww

.wr-

W

~‘m-y—v-

WW1

.

"r

we-..

—_,

.

.___V--

.._

..

,

October 24, 1971
g

I

wag-

In-"V'VI‘

—-

‘4‘

”our

“-1”

—W-'

-

—mey.wr.«—wnu—vmww

w—r

rw—v—z-«sw-u-nvrrv-

WWW'r-W‘VW

WWW;

Michael Sheard, M.D.
Yale University School of medicine

New

Haven, Connecticut

Dear Mike,

it

I have read and re—read your proposal, and find
am not fully acquainted with the status of research into
the treatment of psycopathies, but this proposal has both clinical
and theoretic interest, and should be acceptable. More important, it
should add some solid information to the problem of the relation of

quite

good.

I

brain function to behavior.

it

My suggestions are few:
would be important that
you become better acquinted with the Monroe methods and to that
end
would be useful for you to either try some alpha-chloralose
activations, or to visit his facility and watch Monroe, or both.

it

Secondly, since there will be accurate monitoring of the
blood levels of lithium, there is an interesting problem, that of blood
levels of substances and their relation to the EEG effects, to which you
can contribute. Should you condider taking a blood sample at the time
of the EEG, the value of that measure could be compared to the EEG

values (changes).

application is deficient in not noting the many reports
changes with lithium that have appeared. I recall reports by
Mayfield and Brown (J. Psychiat. Res., 1966), Pfeiffer (J. Clin. Pharmacol.
1969), Platman &amp; Fieve (Br. J. Psychiat, 1969), and more recently, reports
by Johnson, Gershon and Korein, and by Itil-- the citations are not
available to me. In none of these reports have the relation between
drug effects and behavior been verified, and this deficiency is related
in part to the inadequate quantification of the EEG and to the incomplete
nature of the behavioral and blood level studies. I would also suggest
you review the recent V.A. report on blood lithium levels and behavior,
of

The

EEG

edited

by Prien and others

at Perry Point.

As I mentioned, we are prepared to assist you in the
recording of the records in a way that would permit quantification with
the techniques available to us.
My

best regards

and

best wishes.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>w.

‘Wv

.._—W..~—w_v— w. av“

pwuww‘F-i'w‘y-w .,~.:- up»... V'. n: ,u. x" .....m .— -

W

v. h. WW...n

Dr. G. Dolce and K. Offenloch
E. Merck

V

L.

A

..
wmv
a .r,

7

.m. “a.-.

.. ».—. ,v-

m

--~-—..w.~w...—Wa". r. vw.-~.,.-.-_._....-m-r

.

um manw—rv—WV—u

October 23, 1971

Darmstadt, Germany

Dear Drs. Dolce and Offenloch,

I very much regret not receiving your telegram, for I
did have the chance to return to Frankfurt, but only for a day. I
an interested in visiting your laboratories, for when I was in
Ingelheim, I enquired about your programs, and was told that they
were among the best in Germany. .It is probable that I will be in
Europe again before the end of the year, and I should be pleased
to accept your invitation at that time.
In the interim, I am enclosing a preprint of a progress
report written a few months ago about our ongoing program; and a
reprint which describes our theoretical views. Perhaps, these will

be of some

interest.

My thanks for your kind invitation and
the communications were unsuccessful.

my

regrets that

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_—.—.W..—v

m—w...

wuss,” ..

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                    <text>v.

zen—m.»

*x-n’V‘

-—~xv.g-g.v.r~«,

.—

—.

9"».

A
-

October 22, 1971

w.

Dr. William Tabor

army-warr—v-r-wp-

A. B. Robins Co.

Richmond, Virginia
Deer

Bill,
I have asked

my

assistants to transcribe the data
is some

1118 experiments on the forms provided. There
ambiguity as to whether a form should be provided for each
from the

AER

experiment, or for the variety of experilants for each subject.
I have enclosed a xerox copy of one record for your review. If this
is satisfactory, the data sheets will be prepared for shipment.
If you prefer another format, please advise.

for your kind hospitality and
understanding during my recent visit. Also, I very much appreciate
the description of the use of doxeprem in heroin overdose. It will
be made available in my clinic and we will test its use for our
Thank you very much

problems.

My

best regards.

'

ren—

Sincerely yours,

.

‘im'VIJ'T‘V‘qu‘U

Aux

Mex

Fink, M.D.

Professor of Psychiatry

v.

-r:'u

mauww

\

�</text>
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                    <text>October 22, 1971
Dr. K. Stockhaus
C.H. Boehringer Sohn

Ingelheim

Dear Dr. Stockhaus,

Enclosed is a supply of naloxone powder, for your
use in animal studies, in the development of other narcotic

antagonists.

Good

luck.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

‘

(
"r

V‘A‘w’xI4l'.‘

w...“

7;.

mar:

.
.

,

mirr‘anv‘

Twp-nu-

�</text>
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                    <text>October 22, 1971
Dr. F,

J.

Boehringer
Ingelheim

Kuhn

Dear Franz,
Dr. Stockhaus has written, requesting naloxone
for his research into the narcotic antagonists. I am
pleased to enclose a supply for his use in animals.
powder

..
v,
,.

“q...

..

I have not had the time to review the report on
but as soon as I can see the top of my desk, I will
get a copy for you.
l—Dopa,

-

I hope our meetings were helpful.

.‘.,

..

“Neurm,”

My

best regards,

and Happy Hunting

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

-4

,A

,1,

.

Jimmy-vr-w-«ww—a—mr

r.»
,——
-

Mair-2r"

Twmn-hx‘wjﬂ

Mp4»-~M-,i-

7,.”

, ..

,

,

.L, #,._.V -zﬁ 7,77,; .w"
-7

,

k

.,

-,.

,

,

.-.—,-.-..n_-:«. M» ~_.

�</text>
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                    <text>October 21, 1971
Dr. Daniel X. Freedman

Chief Editor
Department of Psychiatry, Box 2011
University of Chicago,
950 East 59th Street
Chicago, Illinois 60637
Dear Dan,

are enclosing revised versions of our report "Unilateral
ECT: Effects on Depression, Memory and the
Electroencephalogram". we have redrafted the results section,
following the cogent suggestions of the reviewers:
We

and

Bilateral
(1)

found the

patients responding to drugs instead of ECT?
difference in clinical effects between unilateral

Are

We

and

bilateral treatments to persist after statistical "adjustment"
by regression analysis - and have described our data more fully
on page 8.

our

(2)

own

Are

differences

suggestion (P8.

due to age or not? we try to answer
on page 12-13. We were unable to

11—12)

assert that age was a contributing factor to the clinical difference
in unilateral and bilateral HOT.
(3)

Confusing pages

8—9.

restructured the presentation -

Critic is correct,

we

issues of this study are important, and
to contribute to the discourse.
The

Again,

my

and we have

believe more clearly.
we

would be pleased

thanks for your consideration.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>October 20, 1971
Dr. G. F. Blane

Reckitt

&amp;

Colman

Danson Lane
Hull, England
Dear Gary,

is our application (finally) for support for
research. I an optimistic that this will gain approval,
particularly since my government is showing special interest in
the narcotic antagonists.
I have received the note regarding change in shipment
route for M—99. I called our BNDD and am assured approval
has been sent to the British Home office and to Reckitt
Enclosed

MrSOSO

and Colman.

I enjoyed meeting Dr. Lewis. You may tell him there have
been additional meetings of the FHA Committee on treatment; and
NIMH has appointed a select committee to
plan research in the
antagonists. Its first meeting is October 28.
Thanks again

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>October 19, 1971

Prof.

H. M. van Praag

Groningen, Holland

Dear Dr. van Praag,

First, let me thank you for the opportunity to
participate in the fine symposium of the Biological Society
earlier this month. You are to be congratulated in arranging
such a fine discussion and enthusiastic audience.

Dr. Freedmen will write separately, I am
you that both reports, on heroin and marijuana,
are now completed and require the final typing and editing. THe
two drafts should be completed by October 27 and should be in
your

writing to

As

tell

hands shortly thereafter.

to

new York

until last

up on my work.

I regret the delay, but I did not return
it has raked this time to catch

week, and

'

,Incidentally, Dr. Geerlings was most gracious in
arranging a trip for Dr. Petersen and myself to visit the Cosmos
Club. This was a most interesting experience and we are most
grateful for the experience.

visit to

New

Please let us know of the dates of your forthcoming
York, and we should be honored to arrange a visit.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>r-

“.1:

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m.

avg-pr m...

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mm

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I-«~."~

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.wpwvr"nr‘;»w

October 16, 1971

u
a

x
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F’v‘w’ﬂvw"

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-

"vu-vwrv'r

WWII-as

Dr. William Bunney
Chief, Div. Narcotic Addiction &amp; Drug Abuse
National Institute of Hental Health

Rockville, Maryland

Dear

Bif,
The

scientist

at the recent meetings in
H. O.

who

presented an interesting report

Amsterdam was

J. Collier

Miles Laboratories
England

(I regret I don't have a better address)
His

presentation was titled

Analysis of Drug Dependence"

"A

Pharmacological

.

I look forward to joining the discussions

on the 28th.

‘

.nzwrrr'urmm

Sincerely yours;

-

WWK’H,T'

Max

Fink,

M.D.

Professor of Psychiatry

,7

a.

m».

——.

,

”mus“!

.

v7,

‘

�</text>
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                    <text>.

October 15, 1971

‘

wrmwn

Dr. Louis Bozzetti
Deputy Director, NCMDA
Washington, D.C.

‘2"

m".

art]

Dear Dr.

"WW-1;.“

.

Bozzetti,

I returned from Athens on October 6, and have been
catch
to
trying
up on my work since then. In Athens, I found that
the team had examined 31 chronic hashish users, and were preparing
to examine an additional 20. The data is most impressive, and we
are heartened that an intensive examination of these men will

be

significant.

We

have, therefore, proposed to

NIMH

to extend the

study, and I am now preparing the documentation they requested.

For this reason, I am not planning to return to Athens
end
the
of November, or mid-December.
until
At this time, there is little that can be served by a
would suggest you visit us in New York and I can bring you
up to date on the findings. If you wish to observe some of the
subjects during their examination, perhaps it would be advisable

visit. I

to wait until the detailed examinations are in progress.
Come

visit again.
Sincerely yours,
Max

Fink, M.D.

professor of Psychiatry

'
'-‘

‘.¥WF‘T€W,TW

"
"NW-

'9

Tyler-“rm;

C .3

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                    <text>October 14, 1971
Dear Dr. Mechoulam,

I will be at

I received your itinerary after your
my

office all

day

letter.

in Thursday, October

21

(212 369 8488), and I look forward to hearing from you.

Unfortunately, I will not be available Friday.

If you cannot reach
on Saturday (516 466 5444).

me

on Thursday,

I should be

home

‘

In Amsterdam, I heard some preliminary data to be
presented in Stockholm, and I believe that should be a very

interesting meeting.

I hope that you will be able to look into the

development of a long acting antagonist.
Good

luck

!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>‘rwmwmw-w

v'

;
Vv'r:wvuv

av“?

—-——|v~mr-‘;mmrl

‘vo.VVIUV~.)

.957

-

.,,w

a

October 14, 1971
x:r-v

M’WIWVw-‘r

Dr. Joseph Wortis
Maimonides Medical Center
Brooklyn, New York

.'
«v—

Dear Joe,

I regret that we are unable to supply the manuscript
"Contributions of Unilateral and Multiple ECT . . .” The report
has been divided into two smaller presentations and are being
published elsewhere.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

w
arr:

.

:-

'x‘rgy-g-jbgwwfrvgew

',-_'-

'.
"u"

MW

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                    <text>wx-

~n,
~

me

"4““:

October 14, 1971

#"W~,

W‘Ac:

‘71.:-

7-7.0

Dr.
FDA

Barrett Scoville,

M.D.

Rockville, Maryland
Dear

Barrett,
I

am

writing in reply to your request for information

from our study of l-alpha-acetylmethadol (IND 6590).

are completing the data analysis for the two
groups of patients, 10 each, who received methadone (100 mg daily)
or l-alpha~acety1methsdol (Bx/wk). Three of the patients are
now completing their 4th month of treatment, and our evaluation
period extends for 6 months in each case.
We

initial

it

is clear, however, that
l—alpha-acetylmethadol is equivalent in every way on a 3xlweek
schedule to methadone-w in patient acceptance, staff awareness,
urine test results, duration of antagonism (cross tolerance) to
injected heroin, and drop out rates. Indeed, I am impressed with
the data, and have asked my associates to complete a preliminary
report for your use, as I believe that further testing of this
drug is warranted, both in the maintenance of patients, and during
the ambulatory withdrawal schedules now actively used in my city.
From

the

I believe

Committee and/or
My

group,

you should

SAODAP

alert the

Methadone Advisory

that such data is available shortly.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

difference in our recent results from earlier published
results is in the dosage schedule of 70-70—80 mg.

P.S.

The

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                    <text>rW

WW

__

_

WWW WWWWWWWWWWWV-.- WW -

October 14, 1971
Dr. Jonathan 0. Cole

Boston State Hospital
Boston, ¥assachusetts
Dear Jon,

Previously, I sent the reports by Small &amp; Small and
Dornbush. The Essman report was returned, and has been re-edited.
Enclosed are two copies each of the Abrams and the
reports. The Essman paper is better, but if it still is
unsatisfactory, please do not hesitate to edit it. I have
asked him to send me the glossy prints for his two figures and'
these will be sent with the next batch.

Essman

The reports by Volavka, Fink, and the Q 8 A are
in their final typing and should be done by Friday or Saturday.
I am distressed only about the section by Pitta-- he had promised
it two weeks ago and when I called him on Monday, he said it had been
mailed. Lost ? I hope not-- but he promised to send me another.

use, which

There

will

It

is also

an

come with the

introduction that I wrote for your

next batch.

has been fun, and I hope the texts are

satisfactory.

Sincerely yours,
Max

P.S. I cannot be sure-- did you ask
Dornbush and Smalls' reports 7

me

Fink, M.D.

to send you duplicates of the

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                    <text>October 14, 1971
Dr. Sidney Malitz
Chairman, Research Commission

NYS
New

Psychiatric Institute

APA

York City

Dear Sid,

It

was a pleasure to discuss our common interests, both
en route to Europe and in Amsterdam. Also, I want to thank you both
for your help in the silver shop in the Rokin—— my daughter was
delighted with the silver stage, and I am not sure she will release
the Turk on the flying carpet to my friend, Turan.
With regard to your kind invitation to join the task
APA
the
force of
on drug abuse, I am pleased that the APA is
desirous of broadening the base of its experience. Unfortunately,
my schedule during the cominh year is overburdened by trips both
in the U.S. and abroad, and I will be unable to serve. A1 and I
have discussed the opportunity, however, and would suggest that
you invite Dr. Richard Resnick, Assistant Professor in our
Department, to serve. Dr. Resnick has been responsible for the
clinical programs in cyclasocine since 1968, and has the most
experience among our staff members. He is well qualified to present
our experience.

at

recommendation is acceptable, he can be reached
address, or by phone at 212 MO 2-1899.

If this

my

Again,

my

thanks and

my

regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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                    <text>October 13, 1971
Dr. Monique Broude

NIMH

5600 Fishers Lane
Rockville , Maryland

Dear Monique,

I am writing to request five (5) additional grams
of diacetylmorphine (heroin) for our studies of the duration
of induced cross tolerance of 1-alpha-acetylmethadol and
methadone. These studies continue our evaluations of these drugs
under

FDArIND

6825 (methadone) and FDA-IND 6590 (1—a1pha-acetylmetha-

dol). In both these studies, heroin is used in the ”heroin
challenge” model (see reprint attached). we use single doses
of 25,50,and 75 mg heroin at 24,48,72, and 96 hours after a
dose of methadone or l—alpha—acetylmethadol to establish cross
tolerance.

These stddies are part of our NIMH study program, ”Opiate
Effects on Brain Function and Behavior", MB 19476, and a copy
of that protocal is enclosed.

I

also enclosing the appropriate BNDD drug request
I hold BNDD registrations AF1732103 and PF0024555
for research studies.
am

forms (2513).

le would be grateful for a renewal of our supply
of diacetylmorphine (heroin) for these studies.
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>October 12, 1971
Ralph Jecobeen, M.D.

Deputy Medical Director
Endo

Laboratories, Inc.

1000 Stewart Avenue, 3
Garden City, New York 11530

Dear Ralph,

thanks for your contribution to the programs of the
College. We will use the grant to buy some equipment which
we sorely need.
Mnny

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:jb

�</text>
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                    <text>Prof.

October 12, 1971

R. Mechoulsm, M.D.

Laboratory of Natural Products

The School of Pharmacy
The Hebrew Uhﬁversity of Jerusalem,

Faculty of Medicine

Dear Dr. Machoulam,

I can be reached at my home, (516) 466—5444 on the
weekend of October 23rd and 24th.
.,.

”.1“:—

5w

;.

I too was surprised at the response of SKF.
you can do something to change their mind.

Perhaps

"prmp‘

I

7”

'."‘"{‘

do hape

that

you

the long acting antagonists.

will be able to

do something with

Sincerelyﬁyours,
a.
A

f’c'f'ﬁw-

"Jr—1

"‘

'V’Sr‘

,,

gala.

awry-z

“‘71

(7
pr;

'(Vp'

2.-

19.1355»!

s

.;1'/,&gt;r.

6,9"

‘
njrwt

Wt.

mna’mi‘w:

7"Hl'pefit'i-é

$57."

7.va

v.20

Fink, M.D.
professor of Bsychiatry

Max

'ﬂﬁhﬂ“,‘.~;v*

MF:jb

�</text>
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                    <text>October 12, 1971

Dear

Irv,

Dr. Harold Escover was a student of mine at Hillside
After I left he assumed responsibility for the
training program. With the reorganization at Hillside and his
remarriage, he now seeks work in New York City.

Hospital.

He

him highly.

is a diligent and serious worker and I can recommend
If he can work withing our program, perhaps you

Ihoﬁid see him.

Mex

Fink

�</text>
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                    <text>rvt'muwl

M-mw.m“\mvm‘§w’

,—

-

nw—uv—mmmwmm—w—w- m"wmr—V'-v

OcTober l0, i97|
Dr. PeTer Geerlings
Academisch Ziekenhuis
AmsTerdam

Dear Dr. Geerlings,
Thank you for your kindness in
the Cosmos Club. IT was an unusual experience,
inTroduclng
and The slghTs were more poignanT Than The descripTions inconr
liTeraTure. lT was anxleTy provoking To see so many young people

FirsT,

I

wanT To

me To

indulging in whaT was apparenle a wiThdrawal phenomenon. ThaT
Their elders did The same wlTh alcohol dld liTTle To miTigaTe
The impression ThaT They were induging in a public phansasy world.
i
was mosT sTruck by The young

Than

girl

from Chevy Chase, Maryland.

as iT may, perhaps your soluTion is much beTTer
ThaT of sending These young people To prisons.

Be ThaT

ours--

On my

llliciT drugs

reTurn

i

found your

on my desk, and
Taking an imporTanT sTudy.

SeparaTely,

I

am

i

arTicle

musT

on The

analysis of

congraTulaTe you on

under—

sending you our laTesT summaries.

i

believe These will be disappoinTing, since They reflecT The
usual academic sTudles, so far from The reallTy of The Cosmos

Club.

My

besT regards and

my

Thanks for your kindness.

Sincerely yours,
Max

Fink,

M.D.

Professor of psychlaTry

�</text>
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                    <text>v--,-—.‘ «v—

,.mmm

__

._...

“.mm.

OcTober l0, 197|
Dear Al,
i

should like To recommend Richard Abrams for

membership in The formulary commlTTee of MeTropoliTan HosplTal.

years ago, aT your requesT nominaTed Richard
Resnick; and iaTer, asked Mrs. Cruzado To lnviTe me To dome
Some

I

I

of The meeTings.

These are held aT irregular lnTervals, buT The
is responsible foo The assay and deTermlnaTlon
of Those psychpharmaceuTicais ThaT are To be included in The
formulary, eiTher on a perminenT or Temportry basis.
CommiTTee

i

believe

ThaT Dick Abrams

is well qualified for

This posiTlon and considering The years ThaT Dick Resnick has
served, lT would be To every one's advanTage To make This requesT.
Thanks.

Max

Fink,

M.D.

�</text>
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                  <elementText elementTextId="106342">
                    <text>F

._...

M.— .._

,

.7-......._. w -.

.

r

we,“

Him“...

...,... w.

...._._.W...,.,,...r.w..._..._.._.._..-~..e.- w w... ,, he-..

WW..-

-h.-.,,..___

-__,

W

”at... in"... _,_._.__,._,n_......~.MW-

” _._.i.._

“WWW...“ t__

October 10, 1971

9

..

V

mm..-

“rum—v

Dr. John Bergen
Chairman, Membership Committee

Society of Biological Psychiatry

WW

Dear John,

I am pleased to nominate Dr. Michael Alan Taylor
in the Society of Biological Psychiatryﬁlﬂinner,_uith
membership
for
Dr. Robert Levine, of the 1969 award of the Society, his work needs

little

introductionéj

resident physician, he was most industrious and
undertook independent research into the concomitants of post—partum
schizophrenia. Demonstrating that the sex of the offspring bore
a significant relation to illness in the mother, he subsequently
demonstrated that hormonal effects operated concurrently with the
ataractic properties of drugs-— a conclusion derived from his data.
As a

During his residency, also, he carried out independent
of the lactate infusion test for anxiety neurosis, confirming

verification
the work of Pitts

and McClure.

Since returning from military service, he has established
of
independent studies at Metropolitan Hospital, in
a variety

anxiety and in schizlphrenia.
I

am

pleased to

recommend him

for

membership.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>chober l0, l97l
Dear irv:
For a number of years
have been unhappy wifh fhe
of
performance
Mildred Hill on my service. Early fhls year, her
absenfee record was so bad, and her performance when available so
confrary fo fhe aims of fhe program fhaf discussed her
performance wifh her. l received no saflsfacfion and Then
referred fhe maffer f0 you.
I

I

You suggesfed fhaf
speak +0 Mr. Torres, which
did do; and he assured me fhaf he would have her reassigned fo
anofher division, if indeed he was unable fo discharge her.
l

i

fold

in checking on fhe

leffer

from fhe Afforney General,

sfaff fhaf Miss Hill sfill is
involved wifh our oufpaflenfs; fhaf her affifudes are sflll
referred fo as confrary To our program goals; and fhaf she has
l

was

by fwo members of The

been known fo voice public concern wlfh our experimenfal
programs.
Wifhouf going info fhe merif of her compefence as
a counselor (a compefence fhaf has nof been demonsfrafed in 5

years of associafion), do believe fhaf her affifude fo research
problems is defrimenfal fo fhe successful complefion of our
projecfs; and on fhis basis, again requesf fhaf she be separafed
from my service, complefely and immedlafely, for the good of fhe
I

service.

lany

fhanks.Max

Fink

�</text>
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                  <elementText elementTextId="106344">
                    <text>Oc+ober l0, l97l
Dr. Glullano Dolce

E. Merck A.G.
"v

'F

Frakfur+ers+rasse 250
6|

Darmsfad+
Germany

Dear Dr. Dolce,

0

wmr

before

I

Dr. K. Offenloch was klnd enough +0 call me
Jus+
had +0 leave WUrzburg and +ell he of
your ln+eres+

ln +he quan+l+a+lve programs for

EEG
of drugs. On
re+urn +0 Frankfur+, +he +lme was analysls
+00 shorf +0 allow us
+0 mee+.
my

am enclosing a reprlng descrlblnq +he
+heore+lcal
basls for our s+udies, and a progress repor+
wrl++en some mon+hs
ago +0 glue an apprecla+lon of +he +ypes of s+udles we have found
ln+eres+ing and feasible. These lnclude +he lden+lflca+lon
drug proflles, deflnl+lons of bloavallabill+y, and some doseof
I

comparisons.

l

+rus+ +hese are helpful and would be pleased +0

hear fur+her of your in+eres+ ln +hls problem.

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychla+ry

�</text>
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              <elementText elementTextId="50226">
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              <elementText elementTextId="50232">
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              <elementText elementTextId="50233">
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                    <text>.

a».

my

1"

u,—w&gt;‘-(w—"‘

October l0, I97l

.m.

w

m.-

"WW.

Z 3856
New York

Times

v.—(——-’-wv_——r.,

Dear Miss,

w...

n.

......

.7

m"-

.7

v

secretary of six years has left following
am seeking a competent secretary/
The Division is involved in the
receptionist.
typist/
development of new treatments for the mentally ill, with
special emphasis on drug abuse. The secretary acts as the
administrative assistant for a large staff, assuming authority
for expenditures and various services in my frequent absences.
My

her marriage, and

I

The work includes the maintenance of some records,

.»

"—n—uwnr—

allocating charges to various research funds, handling some
finances, and typing of reports. Most imperative, the position
requires someone with judgment to accept calls and allocate them
to the appropriate scientists.
if the position interests you, please call me at
2l2-

369 8488.

u'm—

‘K’F—W

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

l

l

l

l

l

E

�.—

.mww

J..."

m

.,

~mm

~‘m'rVn-r ~m‘mwV—mm

'vr-‘vsw

October l0, l97l
Z 6i22
New York

Times

Dear Miss,

Recenfly, my secrefary/ adminisfraflve assisfanf of
six years ieff affer her marriage, and am seeking a replacemenf.
The focus of our office is in The deveIOpmenf of new mefhods
fo freaf drug abuse and various ofher psychlafric problems.
i

secrefary is responsible for managing fhe office, felephone,
and considerable fyping of reporfs and pubiicaflons. There is
some lighf bookkeeping as if is necessary fo keep some
check on the expendlfures of various sclenfisfs in +he program,
and There are five fo eighf accounfs open af any Time.
The

The

office is at

if such
af 2i2-369 8488.

a

i02 Sfreef and

Fifth

Avenue.

posifion lnferesfs you, please call

me

“W...

W.

Sincerely yours,

y.

a,»

~;———-~r,1-..—,

-\

Max

Fink,

M.D.

Professor of Psychiafry

�</text>
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ywr'w

M.

.

y.

”7, w. -w. “NV—”Wrm‘w-vr:w—.,w~.w-—m w.-.._.mw—W~am—ﬂ-Tv—w7......» m‘\-r‘——— wee—W.
»

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7-...r__-.._ _,_, .7-.__.._._ _._r,_. . s..._... W
‘

w

V

October 10, 1971

Dr. John Bergen
Chairman
Membership Committee

Society of Biological Psychiatry
Dear John,

I am pleased to nominate Dr. Richard
in the Society of Biological Psychiatry.

Abrams

for

membership

Dr. Abrams is a (nil time member of the research staff
of this Department and has been an active leader in our studies of
Convulsive therapy both during his residency training and as
a memebr of the clinical and teaching staff.

After completing one year as resident, he served his
tour of military duty. During that time, he undertook independent
reasearch into the variety of modifications of electroconvulsive
therapy, including multiple treatments in one session and unilateral
electrode placements. His work served to establish the parameters of
these treatments, and he is now responsible for this clinical program
in the Department.

is studying the effects of penicillamine
role of lactate in the precipitation of

In addition, he

in schizophrenia

and the

anxiety.

He

is an industrious

of the scientific

and serious worker, an avid reader
and an excellent teacher. I am pleased
membership in our Society.

literature,

to recommend him for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

,

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\- -.-

w-.r..v—r-&lt;V"Ww—nwi’ﬂ'w4_.m-.—w.w_—.—.mn_——-uvrw.w~....... F"..—

.n

W...

_

w

-H

w e- ”7—. “m"...

...,

.

.e......._.._v~

.V.

a.

.7

'va-‘W

”w.“

October 10, 1971
Gerald Klerman, M.D.
Massachusetts General Hospital
2

Fruit Street

Boston, Massachusetts
Dear Gerry,

I

am

Dr. Richard Abrams

ical Association.

writing in support of the nomination of
for membership in the lbericsn Psychopatholog—

Dr. Abrams served his residency training at the
York Hedical College. After one year, he was inducted into
the armed services and during his tour of duty, undertook
independent research studies into ECT. He designed and completed
two studies of unilateral and multiple ECT in the treatment of
acutely disturbed depressed and schizophrenic servicemen. His
experience provided the basis for more extensive studies at
the College into the mode of action of ECT, studies hhich he
has carried ott during the remainder of his residency and
subsequently, as an instructor in our Department.

New

has written extensively in ECT; and is now
studies of new drugs in mental illnesses; the
in
participating
of
trial penicillamine in schizophrenia; and the evaluation of
He

war—ru-

as»

w-

n»...-

qvnnr-sW-wwqw

infusions of sodium lactate as a model of induced anxiety. He is
a serious student, well liked by his patients and the staff, and
is an avid reader of the psychiatric literature. He is able
to formulate projects and understands the principles of design
He is one of our outstanding trainees and I
and controls.
am pleased to recommend him for membership in the APPA.

‘n‘w

“a.

v

Sincerely yours,

w—m:

m

«5:-

x
1w.

J-E'l'm-MIR‘

M.—

.

Fink, M.D.
professor of Psychiatry

Max

e 7...

�</text>
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