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                    <text>VFVV.W75'.-r——

:w’mn'rvww-m

,

.nm

march 8, 1971

Dr. William Martin
Addiction Research Center

National Institute of MBntal Health
Lexington, Kentucky
Dear 3111 ,

I

Thank you for the report on EN 1639. It is
hope that further studies will be encouraged.

quite clear

and

Last week I appeared before a ﬂew York State legislative
committee investigating our methadone programs, and heard a
report that methadone was safer than cigarette smoking; that
euphoria and sedation did not occur: and that tolerant subjects
were completely "normal”.
In your report in October to the Methadone Conference, I
to recall that you found methadone and morphine to have
very similar physiological effects, including measures of euphoria.
If a preprint of that report is available, I would appreciate a
copy; and, would you allow a copy to be sent to the committee
cited abate?
seem

Many

thanks.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Hex

MF:kt

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                    <text>pram-www—

~xW-r-

.mwmwry'l‘

:
:‘r-v-c

mvv—‘vvy'w‘

March 8, 1971

,.,

,wr:v—2

.

_Wn&gt;mﬁrm-ﬂ"

—m

Dr. William Martin

Addiction Research Center
National Institute of Mental Health
Lexington, Kentucky

r..-,—&lt;.,—q

,—

vmzme’r‘wmwv-W‘

f

wry-""5

~—~

:
g—

.—

Dear

I

Bill,
for the report on
that further studies will

Thank you

hOpe

1639. It is
be encouraged.
EN

quite clear

and

Last week I appeared before a New York State legislative
committee investigating our methadone programs, and heard a
report that methadone was safer than cigarette smoking; that
euphoria and sedation did not occur; and that tolerant subjects
were completely ”normal".

.mrwwr—r-w

.

In your report in October to the Methadone Conference, I
to recall that you found methadone and morphine to have
very similar physiological effects, including measures of euphoria.
If a preprint of that report is available, I would appreciate a
copy; and, would you allow a copy to be sent to the committee
seem

cited abate?
Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>March 8. 1971
Dr. Edward L. Platcow, Ph.D.
Department of Drugs
American Medical Association
535 North Dearborn

Illinois

Chicago,

Street

60610

Dear Dr. Platcow:
As

requested, I have read proposed chapter

It is well written

are few.

and

authoritative,

32

"Antidepressants".

and my comments and suggestions

Pg. 32$) Paragraph 1: Recent notes suggest that thiothixene
(Havana) also has antidepressant qualities. We demonstrated such
is my impression that Drs. Norman
activity in our studies, and
Pitts and Allen Borger at Pfizer Laboratories, Groton, Connecticut

it

can provide the available documentation.

Paragraph 3. The role of ECT is presented in too limited a
fashion. In every study of ECT and antidepressants, ECT is more
effective and more rapidly (see Cole and Davis, in Freedman and Kaplan,
"Comprehensive Textbook of Psychiatry“, 1967: 1263—1275; Klein and
Davis. Diagnosis and Treatment of Psychiatric Disorders, 1969: 187~322).

important, in suicidal risks, involutional melancholia, and
psychotic agitated depressives, ECT may he 1ife«saving, while antidepressants are too slow and ineffective. Although drug evaluation
is the focus, in my view, ECT is a complex way to achieve a biochemical
change in the CNS ~ which is, after all, the goal of pharmacotherapy.
Most

Paragraph

Too harsh an evaluation. The
show many controlled studies.

&amp;.

Klein and Davis

Paragraph 5.

depressions.

A

references cited by

reason to emphasize the value of

ECT

in severe

Pg. 259, Paragraph 1: English syntax is poor in phrase, ”..., since
these agents block the actions of these antihypertensive agents".

Paragraph 3. The duration of drug effects is generally 48~72 hours.
The recommendation of a 2~week interval between tricyclic compounds and
MAUI seems much too harsh, and too restrictive.
Probably 72 hours are

adequate.

�y‘)

Dr. Platcow

March 8, 1971

—2~

Paragraph 9. I do not know the evidence for restricting
imipramine in epileptice. My own data suggests it may reduce seizure

activity in the brain,

and may

therefore

be recommended.

the data source be checked (see Canad. Peychiat. Assn.

166-171, 1959).
A

J.,

I suggest

6(Suppl.):

restriction omitted is the use of imipremine in schizophrenia,

where excitement states may be precipitated
Plenum Press, 1965, 1; 53-61).

(in Biological Psychiatry,

Pg. 260, Paragraph 2.

Same as ?age 259, Paragraph 9.

Pg. 261, Paragraph 1.

Sinequan

is

now

prepared as a concentrate also.

Pg. 262: Nialamide, and Phenelzine: Efficacy is suggested in
endogenous depressions. The evidence is clearly that such patients
show no response to HAOI, and if there is any application, it could
be in the neurotic depressives.

Tranylcypromine. Same as for phenelzine. Surely, there
that tranylcypromine has been effective over ECT. I
is
would doubt that there are cases ”inapprOpriate for ECT” [such as?) who
may respond to tranylcypromine.
Pg. 263:

no evidence

I trust these

comments

are helpful.
Sincerely yours,
Fink, K.D.
Professor of Psychiatry

Wax

MF:kt

V

.ww‘ﬁw

~v—w.

:‘.’l.‘,‘

WWW”

93¢)Wmm-

Wit-5.

"at

wa-MW

�</text>
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                    <text>March 8, 1971
Dr. Seymour 5. Katy

Department of Psychiatry
Massachusetts General Hospital

Fruit Street

Boston, Massachusetts 02114
Dear Seymour,

I very much regret not making the LaJolla meeting, but I
ill with influenza the day before I was scheduled to leave
for California, and spent an unprofitable week in bed.

became

Your notes were most helpful, and with the changes recommended
by Jim McGaugh and Tom Williams, yielded the enclosed program for
before the appropriate
an BOT meeting. Tom believes he can get

it

committee in April.
Many

thanks for your suggestions, and

my

very best regards.

Sincerely youre,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc .

�</text>
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                    <text>Heron 8, 1971

Dr. James McGaugh
Department of Psychobiology
University of California at Irvine

Irvine, California

92664

Dear Jim,
The application for a conference on the psychobiology of
has been completed, and I am enclosing a copy. Your suggestions
were most helpful, and have been recommended almost in their entirety.
ECT

Williams believes he can get the application before the
appropriate committee in April.
Tom

Seymour Weingarten of Plenum wrote of your new publication
and asked about publishing this conference. I asked that
he send whatever descriptions he develops so that we can make a
decision. Good luck on the series!

series

My

thanks for your help.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>E

:5

E

Hitch 8,

E

g
,i
E

r

1971

Dr. Jerome Levine

National Institute of Mental Health

Psychopharmacology Research Branch
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear

Jerry,

ww-«w

year of MH~13358 officially ends March 31, 1971.
February 1, I requested an extension of the budget period.
copy of that letter is enclosed.
The ~04

On
A

I would be most grateful for a reply, as the school's
budgeting procedures preclude expenditures against this grant
after March 31, unless it is officially extended.
Thank you

for your cooperation.
Sincerely yours,
Bax Fink ,

.‘ft

o

Do

Professor of Psychiatry

MF:kt

�</text>
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                    <text>.

.

ww—

,

,

“I‘m‘,._ a"
.

,.

.

.

w 1-

.--

,,

"nu—m..... ”New

r.

,.,.V

Hitch 5,

1971

Mrs. Edward M. O'Neil
35 Hillside Avenue
Nutley, New Jersey 07110
Dear Mrs. O'Neil:

Unfortunately, the experimental studies described

in the
newspapers are limited to Lexington, Kentucky, Baltimore,
Chicago
'and New Haven. Some research
in progress at the University of
is
California Medical Center at
under the direction of
Dr. Henry Elliott and Dr. JohnIrvine,
C. Kramer. I
suggest she write
to either of these men for advice. In Chicago.
the authority is
Dr. Jerome Jaffe at the University of
Chicago Medical School.
Sincerely yours,
Max

Fink, %.D.

Professor of Psychiatry
MF:kt

'w'

"m"

W‘

""""‘"

r-ww-Wm'$"""'PF

‘&lt;-‘-'

T"

wn'm'rw“

.
Kn.

{ur‘arrrj

g_

'"H‘ﬁ'

WWW-r

w

m.“ m
.-

.-

W...ww.ku-—

�</text>
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                    <text>March 5, 1971

E

s

E

‘1Wr"mm*’“’m“‘"'7'

an

Mr. Norman L. Jackson
531 Evergreen Ave.

Dayton, Ohio 45407

Dear Mr. Jackson:
The work described in the newspapers is experimental and
I know of no center near you. The closest may be the University
of Chicago Medical School, and I suggest you write or visit
Dr. Jerome Jaffe or Dr. Daniel Freedman in the Department of
Psychiatry.

Sincerely yours,

pmww—vw'uwrrw'

Fink, M.D.
Professor of Psychiatry

Max

”wwwqy‘xwmm’rm

W

.
v

M,

rm...-

my

.r'w'

V

Mszt

�</text>
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                    <text>March 5, 1971
Miss Carolyn Adams
c/o 782 Hemlock Rd.
Union, New Jersey 07083
Dear Miss Adams:

the central effects of substances
clinical practice of neurology (neuropsychiatry).

we are investigating
we are not in the

While

of abuse,

letter is detailed about your search for help, but fails to mention,
help for what. Perhaps you should see your family physician or a member
of the staff at either the New Jersey School of Medicine in Newark (try
Dr. Louria) or at Rutgers Medical School, and allow them to recommend
the consultants you may require.

Your

If you wish to detail the history of the symptoms that trouble
you, I will ask one oﬁ our research staff to review the material and
perhaps we may make a more specific recommendation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>rmﬁ mtwm-ww
:a‘

yum-WV“.

_

_

,1”?

nan-umup.

.

"2““...

March 5, 1971

Prof.

H. M. van Praag

Algemeen

Provinciaal, Studs

—

En Acadenisch Ziekenhuis

Psychiatrische Kliniek

Groningen, Oostersingel 59
The

Netherllnds

Dear Professor van Praag:

participated in a number of
in
enclosing
lists ~ the participants
marijuana sessions. I
New
York
and
the
for
the
the December meeting in Puerto Rico,
program
Academy of Sciences in May 1971.
During the past few months

we

am

have

two

For human pharmacology, the names are Don Jasinshi and Harris Isbell,
Leo Hollister, Reese Jones and Roger Meyer. Ishell and Jasinski have
done the best work, published, and may not have new data. Jasinski is
a younger worker with much enthusiasm and a reasonably good speaker.
Hollister is more flamboyant, has done more varied studies, usually
with less controls. Jones is less experienced, and has done a few

studies with limited control data. Roger
but is enthusiastic and knows the data.

Meyer

is the least experienced,

For animal pharmacology of cannabis and THC, Louis Harris, Edward
Truitt and Constantine Mtras come to mind. Truitt is smooth, efficient
and very opinionated. He has unusual data. Harris is a good speaker,
excellent pharmacologiat and widely experienced. He has done extensive
studies in the narcotic antagonists. Hires (Greece), is a very flamboyant,

egocentric, hypomanic experimenter. He grows his own plants: extracts;
radiates; and does extensive pharmacology and toxicology, mostly uncontrolled.
For chemistry, the names are ﬁechoulam, Korte (Germany) and Mirna
(Greece). The other names are Pars and Wall - both recent experimenters.
Mechoulam has the best reputation, but I have never heard him. I like

his written

work.

I do not

know

the others.

For sociological aspects, I would agree with Cole, that the obvious
choice is McGlothlin. I would add Goode and Brotman for your consideration.

�Prof. van Praag

March 5, 1971

~2~

For neurophysiology, there

is little

and the choice

R. Jones has evoked potential data; E. Rodin (Lafayette
and E. Domino have published some EEG data, but have no
and our laboratory has done some work.
may

If I

were to recommend speakers

who

is restricted.

Clinic, Detroit)
recent material;

have a broad experience, which
and about whom I know

suit your purposes (as I understand them),

something, I would
Donald

Leo

list:

or Harris Isbell

Jasinaki

Hollister

Louis Harris
Raphael ﬁechoulam
Wm. McGlothlin

or Edward Truitt
or Constantine Hires
or Eric Coode

laboratory, I

would be pleased to report on our EEG studies;
memory and task performance, and describe our
trials of chronic marijuana use. If you wish a specific neurophysiology
review, you may consider Dr. Jan Volavka of my staff, who has supervised
all the records and read all the reports.

From my own

relate these to changes in

Salemink of Utrecht visited my laboratory
His knowledge of the chemistry of cannabis was impressive
wish his opinion or participation.

Incidentally, Professor

last year.

and you may

The Chief

of the

Dr. Robert Petersen,

NINE

Center for Studies of Narcotic Drug Abuse,

is the principal officer supervising the national

effort in cannabis research.

He

the Congress from the Secretary,

recently formulated the report to

DREW ~

"Marihuana and Health" (dated

January 31, 1971). This report is balanced, and thorough, is more
succinct than earlier statements, and includes descriptions of ongoing
research. It may be useful to invite his opinion about U.S. investigators;
and, to consider inviting him to present a report of the ongoing research,
results and programs, to supplement your other sneakers.
In trying to be responsive, I find that I was lengthy. Please accept
these notes as a contribution to the development of a satisfactory program.
my best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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”ﬂy-.w-wu—xw-v-u-

1..-

—-V

..

.&lt;

March 5, 1971
Mr. Richard

Scsrpellino

General Foods Technical Center
Tarrytown, New York
Dear Mr.

Scarpellino:

Dr. Arthur Zaks of our College has delivered 240 cc of
Narcan (naloxone) concentrate (100 mg/ml). This is to authorize

your experiments in improving the

taste of the material. We hold
the necessary federal and state authorizations for the study of
naloxone, and this request is sufficient to allow your studies on
our behalf.

We request the return of unused material and an acknowledgment
of the amount used for our research purposes.

.0...

Thank you

for your efforts.
Sincerely yours,

WWW—W‘WWWW.

WWNVIIMWW

‘I'rm’u-

WW

Hex Fink, H.D.

Professor of Psychiatry

MF:kt

cc: Walter Schulok

Michael T. McGuire

Jacob,

R. Feldman

�</text>
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                    <text>.‘Rv—

Nu-‘rv.-'-'

w

“fi—u-wrx

'v-r:

-.,-.1wm—u.-.vm-—-vuxm-..n-ww...

—

r'rm

wwwmy~wwnwmp

IV

V

V'-w7-.'

'Wur’dmmu‘lr-ﬁ

*'-'-¢'-w~- .~~-—‘M.

q‘m mm...“— y..."

~..-.....

r," NWT... 7...”.

.—

March 5, 1971

Earl Ubell
Science Editor

Mr.

WCBS~TV
New York, New

Dear

York

Earl,
The TH

center in

New

York

is at

277 West End Avenue.

One

teacher
give some insight is Kip Cohen, manager of the
Fillmore East. I have no knowledge of the impact of this group
on the college scene here, but my son describes a large effect
at Colby College.
who may

My

best.
Sincerely yours,

Professor of Psychiatry

Mszt

�</text>
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                    <text>March 5, 1971
Dr. Jonathan 0. Cole

Boston State Hospital
Boston, Massachusetts
Dear Jon,

It was kind of you to recommend our studios in marijuana
to Dr. vanPraag. I am.tak1ng the liberty of enclosing summaries
of our recent reports for your information.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>March 5, 1971
Dr. Jack Freund
Robins Company
1407 Cummings
Richmond, Virginia

A. H.

Dear Jack,
have been very interested in the use of narcotic antagonists
in treating opiate dependence, and since 1966 have carried out clinical
studies with cyclazocine, naloxone, methadone, and £~alpha~acetylnethadol.
Last fall I was asked to summarize our data, and in conclusion, I
attempted a justification of the logic of the need for a long-acting
formulation of an antagonist.
We

I believe that the methadone maintenance ”solution” to opiate
dependence is politically expedient but not a long~term solution. I
am concerned with the question of, "After a patient is on methadone,

what next?”

"Is he committed for life?"

The antagonist model is theoretically elegant and clinically feasible.
are committed to continuing our studies, have contracted with Food and
Drug Research for some help; and would encourage others to experiment with
other antagonists and long~acting formulations.
wi
We

Incidentally. our experience with narcotic antagonists has led us to
think of antagonists to other drugs of abuse, notably alcohol: and we have
recently carried out some studies to determine the degree and duration of
alcohol antagonism of propranolol.
I trust the enclosed reprints are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>i

‘31

t

41

mm... 7..

mmrvvﬂvw-mw u..." ”——

..__._‘

“WM—mm...

WWW...

"T.

.

l...

Mm,

_._..

v
...

r-'

1.,._....

..,..

Vm"v

March 5, 1971
wmpm-x-uwmwuhv-v

Dr. G. F. Blane

c/o Etabliasement Reckitt Ltd.,

3? 31,
m...

"F“,

15 Rue Ampere
91 Messy, PARIS

5'4:

”I'v—mn—T‘

Dear Dr. Blane:

Since receiving your

Amn-

ww’v-

letter,

we

have:

"-—

~v'

--

of Masosn.

w"

y-w‘vrz"

‘

Im'rz-mr'

ry-H-rl'ﬂﬂr'éﬁﬂ'v-‘W'V'wwu""ﬂ""v‘7‘m

N.Y.

our

(1)

Requested release of our funds for the animal toxicology

have a reasonable bid from Food and Drug Research of
[The release should be approved by mid~March; the study April-June;

FDA

We

filing in July.]

(2) Requested funds in our 197l~72 budget for u~snso, using
your figures as a guide. Because the price is as high or higher than
naloxone, we are not sanguine about an allocation, unless our naloxone
situation becomes critical. We did ask about supplies, and it wee useful
that we did so, since the cost difference between naloxone and
M~5050
appears to be slight.

mu

(3)

N'"m"m’x

“ovulﬂgﬂwul‘

w-I:

aw

mew-5'33"

:Mgmvw-rr-wrwan

non—committal

have written to Dr. Jack Danton and received a friendly

reply.

Based on these data, we will possibly go on with the M~5050 toxicology;
and request a small supply for human study by the parenteral route.

Incidentally, we recently received 6 kilograms naloxone for our chronic
oral studies, and these are in the data collection phase.
The article appeared in Buéincaa week. A copy is enclosed.
Many

.
.

new."

We

thanks for your interest

and

cooperation.

Sincerely youra,
Fink, M.D.
Professor of Psychiatry

max

Mszt

�</text>
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                    <text>March 5, 1971
Mr. Norman L. Jackson
531 Evergreen Ave.

Dayton, Ohio 45407

Dear Mr. Jackson:
The work described in the
is experimental and
I know of no center near you. newspapers
The closest may be the University
of Chicago Modical School, and I suggest you write
or visit
Dr. Jerome Jaffe or Dr. Daniel Freedman 1n the
Department of
Psychiatry.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MP

:kt

�</text>
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                    <text>._...

w~wmvnnv

“Hr-1""-

WWW—

1

March 5, 1971
Miss Carolyn Adams
c/o 782 Hemlock Rd.
Union, New Jersey 07083

Dear Miss Adams:

investigating the central effects of substances
are not in the clinical practice of neurology (neuropsychiatry).
Your letter is detailed about your search for help, but fails to mention,
help for what. Perhaps you should see your family physician or a member
of the staff at either the New Jersey School of Medicine in Newark (try
Dr. Louria) or at Rutgers Medical School, and allow them to recommend
the consultants you may require.
While we are

of abuse,

If

you, I
perhaps

we

you wish to
will ask one
we may make

detail the history of the symptoms that trouble
oi our research staff to review the material and
a more specific recommendation.

Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

MF:kt

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                    <text>March 5, 1971
Mrs. Edward
35

Hillside

Nutley,

New

M.

O'Neil

Avenue

Jersey 07110

Dear Mrs. O'Neil:

Unfortunately, the experimental studies described in the

newspapers are limited to Lexington, Kentucky, Baltimore, Chicago
and New Haven. Some research is in
at the University of
California Medical Center at Irvine, progress
under the direction of
Dr. Henry Elliott and Dr. John C. Kramer. I
suggest she write
to either of these men for advice. In Chicago,
the authority is
Dr. Jerome Jaffe at the University of Chicago Medical
School.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

MF:kt

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                    <text>g

h
g
L

March 5, 1971

Dr. Robert Petersen

Chief, Center for Studies of Narcotics
5454 wisconsin Avenue

Chevy Chase ,

8 Drug

Abuse

ﬁeryland

Dear Bob,

I am writing to bring you up to date
contract study of cannabis use in Athens.

on the

status of the

Following the renegotiation of the contract terms in the
designed the data collection phases of the study, made up the
necessary forms, and scheduled the initial data collection for March.
After sending the outline to Dr. Castes Stefania, we received no
reply for many weeks.

fall,

we

February 20, he wrote: " I wish to apologize for the
long delay in answering you. This delay is due to the fact that a new
law on narcotics has been passed and is in effects since January 10,
and all this time I have been trying to find out whether under these
On

restrictions,

any

investigation

on hashish, which

is included in this
is a very serious

law, could be carried out. This, as you understand,
problem . . ."

Dr. Stefanie concluded his letter with some suggested steps
he had undertaken to clarify the issue, and indicated that
we would be " . . . hearing from me within the next few days."

that

We

have

not, as yet, transferred

any funds for the

project,

Under these circumstances, we have no recourse but to await
a more favorable reply. Unless, there is an alternate population
in which the study could be undertaken.

I will keep you informed.

g

l
.

Sincerely yours,
Max

Fink, M.D.

Professor of Fsychiatry

�</text>
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                    <text>. a.,x.. .
'qwgs'uwwale
7

.

n;

d

'1'W—W'

-

.

.

mmmwm

March 2, 1971

Br. Seymour Weingarten

_..,,

n—a—m

Plenum Publishing Corporation
114 Fifth Avenue
New York, New York 10011
Dear Seymour,

v-zwwmrwrwrmsu—vnwp—v

9-

mw-u

.—~

2

yum-711p

w.

,1

r

Thank you for your letter and the volume, Biochemistry of
Brain and Behavior. I have flipped the pages of the volume, and
find the text readable. There is some bleeding from the page
behind, but this can be corrected by a more opaque quality paper.
The time of production is extraordinary. Congratulations!

If we go through with an ECT conference. it will be with
James McGaugh as a participant. We should consider your series,
and I would ask that you send me such descriptions of the series
on behavioral biology as may become available.
for the marijuana conference we have failed to find
the funds and now hear that the New York Academy of Sciences is
proceeding with the same idea in May.
As

Is there

—

still

psychopharmacology?

room

for another journal in biological psychiatryl,
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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“WW5!-

"Wm-v

..w..._.,..-

v

..

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.

m-V’m~w‘m-‘:«T~1r~v

......

-

‘

w

a“.

~

w‘ ~-~-\-v- u--. --- ;V'*~."'

urn:

wr-wu‘rva I‘q-irer-

rwa-nw.wnx&gt;_x

~a- - w...» '&gt;~-:1~‘::Y:I'i-Ivmu..--I~Vnnw‘a-WNI

March 1, 1971
Mr. Alan Morton

Contributing Editor
Business

Wehk

330 West 42nd

New

Street

York, New York 10056

Dear Mr. Morton:
I read the report, “Fighting Drug Addiction with Drugs“
Week with interest and wish to commend your report.
Easiness
in
It states most of the facts clearly and should be most useful to

your readers.

r)“

“—112.

War

"WWW-Civt-Igz'mm'm

Wmm'

Two notes near the end of the report may be overly optimistic.
Our studies of £~alpha~acetylmethadol fail to support the interest
of Dr. Jaffe. The drug is more complex to use than methadone and
provides no long-term solution. We have already transferred a number
of patients from methadone to cyclazocine, as Dr. Kissin suggests.
Unfortunately, again, the two compounds are incompatible and the

switch-over is

difficult.

Progress, although slow, is continuing, and if your report
stimulates additional interest, as I believe it will, it will contribute
to the solution of a serious problem. Thank you for your interest and
a well written report.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

A

rq—

"r
rm

nun-r,

W

rmxm

Tww-mw-

Mszpt

"mm

�</text>
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                    <text>u, ~,v..=;- “F...

m. V-w‘"

-—-v-

-»\v

»

"Mar

..,

ummxup‘ -. w»- ;‘

”er

2-. ~

’1‘1';a,

-

mun-

ram” .,-i.~~.um.v-..I.-aw-:aw.W7'wnrr-v_~-—---.mr.rv..‘.,

smu—wrw

.

....,........-

P'O‘F"."l‘

March 1, 1971
Dr. Daniel N. Robinson

Department of Psychology

Amherst College

Amherst, Massachusetts 01002
Dear Dr. Robinson:

It was kind of you to send us your c.v. I regret that
are not expanding our study prOgrams at the present time.

we

Dr. 5. Roy John of this Department is in charge of the
research sections of the develoPing mental health center. While
funding is difficult, I believe he expects to begin recruiting
in 1972. You may wish to write to him of your interest.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kg

«wmm mwupyrh" .

.VWV

WHY“

�</text>
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                    <text>T0:

Dr. Alden Loud

Graduate School,

FROM:

Max

DATE:

March 1, 1971

NYMC

Fink, M.D.

pleased to enclose a recent summary of our BEG profile
analysis studies, as the basis for any recommendations you may wish
to make in Westchester to IBM or other organizations.
I

am

techniques are applicable to the Ocean Systems interest
in "neurophysiological responses of the primate brain...”; and to
IBM sales interest in the IBM 1800.
Our

ENCL.

Mszt

�</text>
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                    <text>March 1, 1911

Dr. Henry

Brill

Pilgrim State Hospital

W.

Brentwood, New York 11717

Dear Henry,
We have recently completed two reports in our ongoing marijuana
study program. Using NIMH marijuana we have elicited dose elated changes
in performance and in EEG. These observations must be repsgted for

confirmation, and

we

are awaiting

out these replications.

some more

concentrate

THC

to carry

as I look back at our years of studies, I recall
have Spent much of the time waiting for the supplies, completing
”official“ forms, and answering committee inquiries. Perhaps, in your
role on the Presidential Commission, you may do a service by inquiring
into the governmental procedures for making “legal” and official supplies
of marijuana, THC and hashish available for researchers.

that

we

Incidentally,

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc .

�</text>
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                    <text>March 2, 1971

Br. Seymour Weingarten

Plenum Publishing Corporation
llé Fifth Avenue
New York, ﬂew York 10011
Dear Seymour,
Thank you

for your letter and the volume, Biochemistry of
I have flipped the pages of the volume, and

Brain and Behavior.

find the text readable. There is some bleeding from the page
behind, but this can be corrected by a more opaque quality paper.
The time of production is extraordinary. Congratulations!

If we go through with an BCT conference, it will be with
Janos Macaugh aa a participant. We should consider your series,
and I would ask that you send me such descriptions of the series
on behavioral biology as may become available.
for the marijuana conference we have failed to find
the funds and now hear that the New Ybrk Academy of Sciences is
proceeding with the same idea in May.
As

In there

—

still

paychOpharmacology?

room

for another journal in biological psychiatry/
Sincerely yours,

Professor of Psychiatry

Mszt

�</text>
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                    <text>March 2, 1971
Dr. Thomas Williams

National Institute of Mental Henlth
PsychOpharmacology Research Branch
5454 Wisconsin
Chevy Chase, Hnryland 20015

Dear Tom,
Under separate cover, I am sending 50 copies of
the grant application, Roychobiazogy 06 ECT: Conéeacnce.

Enclosed

is the signed original.

It is a good proposal and I am grateful for the
continued efforts of all the participants.
my

best regards.
Sincerely yours,
Max

Fink,

M.D.

Executive Director

H!:kt

�</text>
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www

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_

—.uw

p»...

-

WWW-w.- mn ”7m- mu-~~m..~-- ”w

March 1, 1971

Dr. Daniel N. Robinson

Department of Psychology

Amherst College

Amherst, Massachusetts 01002
Dear Dr. Robinson;

of you to send us your c.v. I regret that we
are not expanding our study pregrams at the present time.
Dr. E. Roy John of this Department is in charge of the
research sections of the developing mental health center. While
funding is difficult, I believe he expects to begin recruiting
in 1972. You may wish to write to him of your interest.

It

was kind

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kg

�</text>
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W

T0:

Dr. Alden Loud

Graduate School,

FROM:

Max

DATE:

March 1, 1971

NYMC

Fink, M.D.

pleased to enclose a recent summary of our EEG profile
analysis studies, as the basis for any recommendations you may wish
to make in NestcheSter to IBM or other organizations.
I am

techniques are applicable to the Ocean Systems interest
in ”neurOphysiological re5ponses of the primate brain...”; and to
IBM sales interest in the IBM 1800.
Our

ENCL.

MF:kt

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“var-”WWW." mkunww—vw—mmwum.wm~.m vm

-——

We...

m,

m.“

(I‘m-“\V—"varmm

—“

March 1, 1971

Glick Book Binding Co.
32-15 37th Avenue
Long

Island City,

Gentlemen:
we

would

like

New York
‘3

is

one volumesof EEG Clin. Neurophysiol., which
to have bound in maroon with gold letteringv,
)0 U Ill/)4.—
EEG JOURNAL
read:

Enclosed

Letteringsshould

&lt;

V01.

m

m

2930
190 ("I '1"

Vat‘L-

1G7).

ét

1”.”me

mm

Division of Biological
Psychiatry

ENWVWWWI'Umrl-(mm

NYMC

,

A

ZM‘W

you

confirming purchase order, #508605,

separately.

i;Z/j” ‘

gji

C)

///

is going mailed to

Sincerely yours,

\“”’

‘;Z»~z/"

Fink, M.D.
Professor of Psychiatry

Max

,..-—"

“WW

"mat—,mw...

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Mrs. Zahida Kissuna Nafees
1287 Madison Ave., Apt. #7
New York, New York 10028
Dear Mrs. Nafees:
I regrot that our programs do not allow us to appoint a
research fellow at this time. As I know your husband, I will
keep your record in mind and if our situation changes, I will
contact him.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>March 1, 1971

g

Mr. Alan Morton

Contributing Editor
Business Hehk

330 West 42nd

New

Street

York, New York 10036

Dear Mr. Morton:
I

read the report, "Fighting

in Business

It states

Week

with

most of the

your readers.

Drug Addiction with Drugs"
and wish to commend your report.
clearly and should be most useful to

interest

facts

Two notes near the end of the report may be overly Optimistic.
Our studies of £-alpha—acetylmethadol fail to support the interest
of Dr. Jaffe. The drug is more complex to use then methadone and
provides no long-term solution. We have already transferred a number
of patients from methadone to cyclazocine, as Dr. Kissin suggests.
Unfortunately, again, the two compounds are incompatible and the

switch-over is

difficult.

Pregress, although slow,

is continuing,

stimulates additional interest, as I believe
to the solution of a serious problem. Thank
a well written report.

it

and

if your

you

will,

it

report
will contribute

for your interest

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszpt

and

�</text>
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                    <text>March 1, 1971
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

It will be a privilege to participate in the 1971-72
of research seminars at the MIP, and have set aside February series
25, 1972
for this pregram. ECT is an exciting part of our research program
and we should have new data by

Thank yen for the
and co-workers at MIP.

that time.

invitation;

my

best regards to

my

friends

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>March 1, 1911

Dr. Henry

Brill

Pilgrim State Hospital

W.

Brentwood, New York 11717

Dear Henry,
have recently completed two reports in our ongoing marijuana
study program. Using NIMH marijuana we have elicited dose elated changes
in perfbrnance and in EEG. These observations must be reported for
We

confirmation, and we are awaiting
out these replications.

some more

concentrate

THC

to carry

as I look back at our years of studies, I recall
much
have
of the time waiting for the supplies, completing
that
spent
and
”official“ forms,
answering committee inquiries. Perhaps, in your
role on the Presidential Commission, you may do a service by inquiring
into the governmental procedures for making ”legal" and official supplies
of marijuana, THC and hashish available for researchers.
we

Incidentally,

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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—

W-‘rr—w

ww-ww—wnwn—w—rw—w—v—mrw

-

M'W'

www—

March 1, 1971

Jeffrey B. Donfeld
Staff Assistant to the President

Mr.

The White House

Washington, D.C.
Dear Mr. Donfeld:

It was kind of you to take the time to encourage our research
in the narcotic antagonists, and we are most grateful. Dr. Freedman
has sent you reprints of our recent reports.
There is a need for a more intense effort to deve10p a formulation
of an antagonist effective for prolonged periods, in the order of weeks
to months. With the support of the New York State Narcotic Addiction
Control Commission, we have let one contract for such a development with
Food and Drug Research Laboratories of MaSpeth, New York. We are aware
of parallel studies by Endo Laboratories of Long Island, and by Seymour
Yolles of the University of Delaware. Considering the magnitude of the
addiction problem, perhaps more efforts could be encouraged in the hope
of a more rapid solution to this technical problem.
In support of this effort, there are two steps which your office
could consider. In the fall of 1969, we requested contract support from
the NIMH for developing a silastic vehicle and were told that the available
free funds were committed and no centract funds were available. In part,
this was related to the interpretation that available funds were designated
for methadone delivery systems. Perhaps, in the next HEW appropriation
requests, the funds considered for addiction treatment and research could
be designated for "biological therapy of Opiate dependencd'or other broad
designation, thus allowing the apprOpriate NIMH committees to support those

requests which

may

be

available.

a more direct effort, perhaps your office would be able to review
the logic of the develoPment of a long-acting antagonist, and if you found
the logic as compelling as we find it, you could bring this to the attention
of the Secretary, HEW or the Director, NIMH.
As

Again,

my

thanks for your encouragement.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>March 1, 1971
Membership Secretary
American PBychiatric Association
1700 Eighteenth Street NW
Whahington, 0.0. 20009
Dear Mbdhm,

After some consideration, I am writing to request
reinstatement of'my fellowship in the APm. I trust this is possible.
Anticipating favorable action, I am enclosing the 1971 dues.
Sincerely yours,
Mum

Fink,

M.D.

Professor of’Peychiatry

�</text>
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                    <text>April 30, l97l
Dear Walt,

It wlli

helpful to

be able to place Mrs. Heldman on
The
the College payroll.
College will not risk her employment without
permission from Immigration. The say, if she is caught, she is
be

deportable.

will continue to pay her, under the guise of our "ignorance"
for
should, with your help, make every effort
to get the appropriate certificates.
We

a few months, but she

I'll

call next

Keep up

week, on

my

return

from Washington.

the good work.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                  <elementText elementTextId="106234">
                    <text>April 28,

1971

Dr. Harold Williams

Univ. Oklahoma Med. Center
Oklahoma

City,

Oklahoma

Dear Hal,

are interested in someone with the credentials
of Al Salamy, and I thank you for thinking of us.
We

present programs are focussed on the EEG and behavioral effects of opiates, their antagonists, cannabis, and a few
new psychoactive drugs. I have been interested in having someone
join us who could actively participate with psychiatrists and
psychologists, with a focus on the EEG analyses. There is just
Our

too much work for me.
We

an

IBM

now

have our systems running

well, focussed about

1800 with the usual supporting equipment.

living in

The only

caveat that should be discussed is that
is not the best choice

York at the present time
an American can make.
New

I would like to meet him. I will be at the APA in
Washington all next week but after that will be in New York.
Is he going to be East anytime soon ?
Again, thanks for thinking of us. If these notes
call (collect 212 360 7900 x245).

him, have him
My

best regards.
Sincerely yours,
Fink,
Professor

Max

M.D.

interest

�</text>
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W.-—.—..—.——

“rump-1

-v

n—aw—~.mmnmww_u-wn

April 28,

1971

Dr. Roberto Derbez

ﬁw‘n’w‘rﬂv‘w

Secretary—Symposia
World Congress of Psychiatry
Mexico City, Mexico

IVV-vr—lrmr

Dear Dr. Derbez,
-"'-‘H&gt;"m—W'

"
7'
"

w

Enclosed

is

an

abstract of

my

presentation before the

symposium on "EEG Correlates of Mental Disorders" during the
Vth World Congress of Psychiatry.

may—paw

I should be identified as "Professor of Psychiatry,

Director, Division of Biological Psychiatry,
College, New York City."

and
Min—erv-r-u—nw

New York

Medical

I will present my report in English and will use
conventional small slides (2x2 inches).

‘

,,

“away”,

Sincerely yours,

‘w-uv'w'rn

,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>April 28,
Dr. Hans

Kosterlitz

University of Aberdeen

Fosterhill, Aberdeen, Scotland

Dear Dr.

Kosterlitz,
I look forward to joining you in Aberdeen
for the invitation.

and I again thank you
w-wrw

~

:-

”WV-Fr"

‘.~

1971

we

on

July

will discuss ”Clinical Studies of Cyclazocine

Naloxone in Opiate Dependence", and the authors are, as
Drs. Mi Fink, A. M. Freedman, R. Resnick and A. Zaks.

12—13,

and

listed,

”aw-ru—

gar—wwrwm‘mrt.

"n":

m.

A

I plan to bring my wife to Europe as well as my two
daughters, ages 13 and 15. If accommodations can be made at the
Hall of Residence, I would appreciate two rooms; if not, would
you make reservations in a hotel, two rooms, with planned arrival
the day before the conference, on Sunday July 11 ?
We

will provide

a

manuscript, according to your

instructions, before the stated date of July
Aberdeen.

1.

I look forward to the conference, and to visiting
Sincerely yours,
Max

York Medical College
Department of Psychiatry
New

Fink,

M.D.

�</text>
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                    <text>April 22, 1971
New

York

Hospital

Medical Systems and Computer Services
525 East 58th

New

York,

Attn:

New

Street

York lOOZl

Mr. Roy Hjelmar

Dear Mr.

erlmar:

enclosed check in the amount of $180.00 (#l23574), was
erroneously received by us, Since the disk packs which we ordered
on P0 508852 should be paid by us.
The

You

few weeks.

should receive our check for the disk packs in the next

Thank you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>TO:

I.

B. Schwartz

FROM:

M.

Fink,

SUBJECT:

DATE:

April 21, l97l

M.D.

Neurology

at

Kirby Manhattan

Psychiatric Hospital

Would you arrange for Dr. Morell to visit Kirby Manhattan.
to assist in the assessment of the neurological cases and in the training
of the staff? I have asked the residents to summarize the relevant problem
cases, and these summaries are attached.
When

regarding the

he

staff

Thanks.

is prepared to visit.

arrangements?

would you ask him to

call

me

�</text>
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                    <text>April 21,

1971

Dr. R. Bruce Sloane

Temple University
Health Sciences Center
Department of Psychiatry
Philadelphia, Pennsylvania 191b0
Dear Bruce,

I would like to send you a copy of the SBP report, but it
is still in preparation. For the meanwhile, you may wish to
read the enclosed preprints of our recent studies of unilateral
ECT and a progress report of the ”MEET.
The SBP
when
copy

it

report will

be ready by May

1

is completed.

and

I will

send you a

Sincerely yours,
\

ﬂax Ylnk, M.D.

Professor of Psychiatry

HF:kt

H

£5;

�</text>
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                    <text>April 21, 1971
Dr. Neiton

Pilpcl

Department of Pharmacy
Chelsea College of Science

London, England
Dear Dr.

Pilpel:

I have read with interest your report, “Tablets are not
8 issue of new scientist.
Your focus on
drug formulation as an essential part of clinical pharmacology
has been brought home to us in one of our recent problems.

pills" in the April
Since 1955,

we

have been

interested in developing

a

narcotic

antagonist for the treat-ant of opiate dependence, and while
excellent agents are available, their duration of action is too
short for clinical practicality. We believe that a formulation
which may be effective for weeks, or even months, would be most

useful.

enclosing a copy of a report of work in progress. If
if other concerns in Britain may be able to
contribute to the study of this problem I would be pleased to
discuss it further.

I

am

your laboratory, or
Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HFtkt
one o

�</text>
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                    <text>Dr. U.

J. Jovanovic,

April 18, 1971

M.D.

Universitﬂts Nervenklinik u. Poliklinik

WUrzburg, west Germany
Dear Dr. Jovsnovic,

Thank you for your kind invitation to participate in the
fothhcoming symposium, The Nature of'SZeep, in Wﬂrzburg, September
23~27, 1971. I am pleased to accept your invitation to chair one of

the sessions, and believe I can

I:
II:

an.

m‘vg'V-‘g'lv‘grv‘y'l‘

(Probleme der apparativen Auswertung); and
(Anderungen 1m Schlaf-EEG unter Wirkung
von Psychopharmaka) and item 45 (Kompsration der Einwirkungen von
Schlafmittel und Psychopharmaka). I would be prepared to comment in
either session from my studies.

item

.

3'
’-‘,v“’t-,1

4:.

5

37

I can also prepare a more formal presentation for the
session in item 45, under the title:

Quantitative EEG Classification of'Psychoactive

g.

"'-1?’3W

or

Psychopharmakologie (17.

in (V), particularly items

&lt;

contribution to either:

Mkthodén and Teohnik der Uhtersuahungen,

(I), particularly

In

a-

make a

Drugs

in

Man.

I look forward to the symposium, and am honored to participate.
confident the proceedings will make a valuable contribution to
the physiology of sleep.

I

am

Good luck

!

Wenmwwwnmart

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>April 17, 1971
Dr. S.
NACC

J.

80 Hanson

Brooklyn,

Mule, Ph.D.

Place
New

York

11217

Dear Sam,
Thank you, and Eenry, for thinking of me for your
volume on drug dependence, particylarly for the electrophysiology.
I am pleased to accept your invitation, with one caveat : the
data will not be novel. Our data on heroin, methadone and the
antagonists have been published; the cannabis is in press; and
I know of no new material for barbiturates, cocaine, LSD, etc.

If you still wish it, a chapter on
of Dependence " can be prepared, as
with citations.

of

Drugs

Good luck

”The

Electrophysiology

an academic review

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>April 17, 1971
Dr. Stephen Bernstein, M.D.
ECDEUwFRB

NIEh\

Chevy Chase, Maryland

Dear

Steve,

I would be most pleased to present a summary of the
present status of the EEG progile analysis study program,
with a focus on the application to ECDEU missions.
As I will be attending the conference, you
the presentation to suit your program needs.

will put

may

schedule

I do not have a formal presentation worked out, but
one together and send you a copy before the meeting.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

mf/

WW

-

n
xv

-m'r“~"'ﬁw"m:~t’w.v

...;J

�</text>
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                    <text>,

,,

now

sympwﬁwi.mmmug—ramw-«uww-mu--.. rw'V'r'r' 'v:~r“.wW'-;

'VVI“."Y'V:A&gt;=-I;F:y,...

April l5, l970
Dr. P. Kieihoiz
Psychiafrlsche Universifafsklinik Basel

Wilhelm~Kiein—S+rasse 27
4056 Basel, Swifzeriend
Dear Dr. Kieihoiz:
i

have received various letters from The CiNP Program
my answer To fhe lafesf is enclosed.

Chairman, Dr. Vinar, and

i. The symposium Thai
Tifles lisfed.

has been submiffed

conslsfs of

The

2. The co—symposium is To be made up of submiffed "free
communicaflons". My leffer To Dr. Viner suggesls we could have
all l2 (absfracfs enclosed) bu? would prefer i-8, sugges+ing
9-l2 +0 be presented in The "Free Communicaflons”. The decision
is To be Iefl To Dr. Vinar.
3. He asks The? one of us summarize The proceedings in
fhe Plenary session. Since i am presenfing in fhe symposium,
would if not be eppropriefe for you +0 summarize The sessions?
i

would be delighled To have you do so.

4.

The papers of The symposium and co-symposium may make

find issue of a Journal, and i would ask if you would consider
lhis for your Journal, Pharmakopsychiafrle? (incideniaily, your

a

leffer of February

9 was

nof clear whefher you did indeed wish
a subsequenf issue of

reporf on anfegonisfs and mefhadone for
Pharmakopsychiafrie.)
a

I

look forward To our working fogefher in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
Mszp

w

-

“luv-«.m- urn-.m-

mawwu-M'v

*1

�</text>
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,

7p”!

-v-'uu-

rum

,

Dr. Michael O'Neill East
Pfizer Pharmaceuticals
0.8. Clinical Research Unit

Groton, Connecticut 06340
Dear Dr. East:

UK

7007 and

I believe

carry them out and we will review the data. He
is due here for a briefing and review during the week of April 12.
and I will go over the schedule with him at that time.

that
Wm"’mwﬁm-».w‘erW/m?f'hwy-”'4'”-

I have reviewed the protocols for

Chuck can

It

should be

interesting.
Sincerely yours,

W

W

Fink, M.D.
Professor of Psychiatry

Hex
.-.—

MF:kt

�</text>
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                    <text>r ww-wwwwra

Mar

wx—w—nwm

-.

.

April 5, 1971
Dr. G. Marjerrison

Associate Professor of Psychiatry
Univeratty Hospital

Saskatoon, Sask.

Canada

Dear Gordon,
Thank you for the notes about left temporal EEG accentuation
of slowing after seizures with bitemporal electrode placement.
Recently, J. Volavka repeated the measurements with our detailed
quantitative methods, and there is little question that the
difference is there. I don't know how we missed this in our
studies in the 1950’s, but we did miss it. We have no explanation.
We are
repeating the study, with spinal fluid chemistry
different electrode placements, and hopefully, monitoring themeasures,
seizures.
This last is a technical problem which is under study.
I hope to attend the last day of the 33? ~ (there is a pharmacology
meeting in Atlantic City on Friday~$eturday, and I am scheduled to
speak there).- and look forward to seeing you there. Many thanks for
the note.

Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>‘3‘

April 2, 1971
National Library of Medicine
Bethesda,
Maryland

Gentlemen:

I am anxious to obtain a copy of the following volume which
available at the New York Academy of Medicine or the major
not
is
medical school libraries in the city:
Monographian Ana Dem Gesamrgebiete der Neurologie
und Paychiatrie. Vol. 68, 1939. Stringaris,

It is

M.

an essayy on hashish.

If this is available at the Library I will

request through the

New

make a formal

York Academy of Medicine.

Thank you very much

for your assistance.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

�</text>
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E
p.

April 2, 1971
Dr. Sidney Malitz
York State Psychiatric

New

722 West 168th

New

Street

Institute

York, New York

Dear Sid,

In reading the American Journal of'PByahiatry this month,
understand why you called some months ago. If, indded,
the APA has requested a report on the pharmacotherapy of opiate
dependence, it would be useful to have the data Ind experiences
with antagonists as part of the record and consideration. The
possibilities of significant help to addicts by antagonists are
sufficiently viable to be seriously considered.

I

now

Good luck!

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Me:

MP:kt

�</text>
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                    <text>April 2, 1971
Dr. William Guy

Biometric Laboratory

St., N.W., Room 618
20037
D.C.
Washington,
1145

Nineteenth

Dear

Bill,

is a dibenzothiepine derivative. It is
lO-dimethylaminomethyl—dibenz-[b,fl-rhiepin—HCI. It‘d
formula is:
GP

41299

Lhz-ﬂﬂ- ((3113)::
s/\‘T/
'
'3

It's

1

\--,,A-)\;/\/

molecular weight

I trust this

\§/\

is

.

(:1

303.9; melting point 263°C.

is useful.
Sincerely yours.
Max

Fink, H.D.

Professor of Psychiatry

�</text>
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                    <text>rimmwwww.

www.mwmmmwmw

_.

_

!

E

April 2, 1971
Dr. Sidney Malitz
York State Psychiatric

New

722 West 168th

New

Street

Institute

York, New York

Dear Sid,

In reading the American Journal of'Psyohiatry this month,
understand why you called some months ago. If, indeed,
the APA has requested a report on the pharmacotherapy of opiate
dependence, it would be useful to have the data ind experiences
with antagonists as part of the record and consideration. The
possibilities of significant help to addicts by antagonists are
sufficiently viable to be seriously considered.

I

now

Good luck!

Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>April 1. 1971
Dr. B. G. Dinin

Commiasioneeradical Director

Grasslanda Hospital

Valhalla,

ﬂew York 10595

hear Dr. Binin:

I

pleaaed to accept the appointment a3 consultant in
the Division of Psychiatry at Grasslands Hospital. I look
forward to joining Dr. Gaylin in the clinical training and
research programs at Grasslands, and truat that I may be
am

useful.

Thank you

for your consideration.
Sincerely yours,
Mu; Fink , N. D .

Profcsaor of Psychiatry

MF:kt

�</text>
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                    <text>1"

‘

June 29, 1971
Dr. Jonathan 0. Cole

Superintendent

Boston State Hospital
Boston, Massachusetts 02124
Dear Don,

In l96h665, in St. Louie, Turen and I studied the effects of
thioridaaine (5 mg/kg), chlordiazepoxide (1 mg/kg), each alane; and
thioridazine (2.5 mg/kg) and chlordiezepoxide (0.5 ng/kg) combined

in a croseover design in 24 chronic schizophrenics. Dosages were
maintained for 8 weeks and there was a placebo period of 8 weeks
between each dosage.
The

clinical effects have been published,

as anticipated.

and the findings were

In the EKG, BR, EP and hemogram data, we found consistent
changes with thioridazine alone or combined, and not with

chlordiezepoxide.
The

was

EKG

changes were not striking to me, but the consistency
age of the subjects.

related to the

In the next years, Turan studied high dose fluphenazine and
butaperazine and with both drugs, found similar EKG changes but

significantly less frequently.

In my hands, there are no differences in clinical activity
between thioridazine, fluphenazine and butaperazdne. Since fluphenazine
exists in 4 different formulations, has a very high therapeutic/safety
margin (doses fro: 20 to 1200 mg have been given by us), and induces
little or no EKG changes, I see no Justification for continuing the
use of thioridazine (ace Ban, pg. 150).

�,ww

Dr. Cole

June 29, 1971

~2~

Similarly, I

wonder about the very rapid approval by the FDA
of meeoridazine, a sister compound, for which seemingly excessive
claims have been made (in therapy of alcoholism and anxiety). In
the Sande: date, the EKG changes are said to be equal to thioridexine.

So, my view for both compounds is tempered by the variety of
antipsychotic drugs available, and the suggestion of greater effects
on the EKG. Since I cannot fairly judge the significance of these

effects, being unwilling to

deny them, and attempting prudence, I

that the use of thioridezine be limited to those
specially trained in psychopharmacology for research purposes.

have recommended

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
HF:kt

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                    <text>June 29, 1971
Dr. Roger Meyer, Consultant

Drug Abuse Control
The White House

Washington, D.C.

Bear Roger,

It

to talk to you. Enclosed is a recent letter
sent to the New York City Health Servicoa Administration for
support for the next step for us for MrSOSO.
was good

Should you wish to include such studies in your recommendation,
would be able to provide the data to support studios of a long
acting noloxono for parenteral or oral trials, and extend the

we

clinical trials
Good luck

now

in progress.

in your programs.
Sincerely yours,
ﬂax Fink, H.D.

,

Professor of Psychiatry
HER:

�</text>
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                    <text>June 30, 1971

Christian C. F. Spshr, Jr.
Editor, Lea &amp; Febiger

Mr.

600 Washington Square

Philadelphia, Pennsylvania 19106
Dear Mr. Spnhr:

I

have read the chapter and the index of the preposed book,
or Abuse, and find nothing of significance to suggest

Drugs: Use

its publication.

The reporters listed are parochial, and without a public
record of experience in this field.

matcrisl submittod is a saphomoric synopsis of better
summaries, as in Goodman and Gilman (Ed. III) and Drill pharmacology
The

texts.

The only persons for whom the book
students and relatives of the authors.

may

be of

interest arc the

SinCersly yours,
Fink, MED.
Profossor of Psychiatry

Max

HF:kt

�</text>
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                    <text>up."

"—5:

ﬂux:

mun-NW"...

wwwWMmm-w-ng-r

elm-1":

June 27, 1971

.,.,;

u
&lt;

minnow-Wu

vu-

«-

.,

Mrs. B. Engelman &amp;
Mrs. Bronia Fink
528 Manor Ridge Road
Pelham Manor, New York

WWMWNII'A‘I'

Dear

Berti

Stringaris

&amp;

Bronia,

The

first

with the rest, I believe
literature on hashish.
I have
on both

the translation of the
excellent 1 If you can do as well
will be a major contribution to the

two pages of

volume on Hasyish are

two

it

suggestions:

text, and use slightly wider margins
send you another ream of paper.

Double Space the

sides. I will

Please arrange to purchase the appropriate dictionaries
that you will find necessary, and send me a statement for reimburse—

ment.

v.

.,,.,:.,

Many

thanks.
Sincerely,

.,
.~

”.1575

jg.

’e

eIf
3%

5;
9s

ig.
S:

E
.‘

�</text>
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                    <text>June 28, 1971
Dr. Michael H. Beaubrnn

Professor of Psychiatry
University of the west Indies
Department of Psychiatry
Kingston 7, Jamaica

Dear Dr. Beaubrun:

Since returning to New York, I have had the occasion to
report our discussions to my associates and to NIMH.

it,

Should you wish
I believe another study is feasible
and can probably be supported. We can prepare the study design,
and provide the necessary staff and equipment to assist your

personnel.

The

here,
early August.

timetable of January-April 1972 is feasible
if we provide the necessary data by

and may be supported

For its success, the project will require your recommendation
of two staff members ~ a registrar~psychiatrist and a project
coordinator. The registrar should receive some training with us,
and be responsible for the medical-psychiatric aspects of each
experimental session. If he were available now, it may be useful
to have him participate in the actual proposal-writing. The
project coordinator should be capable of identifying the subjects
and arranging for their availability for study. Such a
person, if
named now, could also participate in the write-up.
and

I would like to recommend the active participation of Drs.
Stuart in this phase of the study.
I believe there should be two preposals

the physiological

(EEG,

ganja.le

~

Ward

a short-term study of

cardiovascular, respiratory) effects of

Jamaican
marijuana, and TliC~free cannabis; and a long
term study of the Jamaican population, to continue to define the

psychological, medical, and biological efﬁects of chronic ganja
use. Both proposals may be funded through a U.S. non-profit agency
should you concur.

�June 28, 1971
Dr. Michael H. Beaubrnn

Professor of Psychiatry
University of the west Indies
Department of Psychiatry
Kingston 7, Jamaica

Dear Dr. Beaubrun:

Since returning to New York, I have had the occasion to
report our discussions to my associates and to NIMH.

it,

Should you wish
I believe another study is feasible
and can probably be supported. We can prepare the study design,
and provide the necessary staff and equipment to assist your

personnel.

The

here,
early August.

timetable of January-April 1972 is feasible
if we provide the necessary data by

and may be supported

For its success, the project will require your recommendation
of two staff members ~ a registrar~psychiatrist and a project
coordinator. The registrar should receive some training with us,
and be responsible for the medical-psychiatric aspects of each
experimental session. If he were available now, it may be useful
to have him participate in the actual proposal-writing. The
project coordinator should be capable of identifying the subjects
and arranging for their availability for study. Such a
person, if
named now, could also participate in the write-up.
and

I would like to recommend the active participation of Drs.
Stuart in this phase of the study.
I believe there should be two preposals

the physiological

(EEG,

ganja.le

~

Ward

a short-term study of

cardiovascular, respiratory) effects of

Jamaican
marijuana, and TliC~free cannabis; and a long
term study of the Jamaican population, to continue to define the

psychological, medical, and biological efﬁects of chronic ganja
use. Both proposals may be funded through a U.S. non-profit agency
should you concur.

�</text>
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              <elementText elementTextId="48852">
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                <elementTextContainer>
                  <elementText elementTextId="103459">
                    <text>June 28, 1971
Dr. Bernard Loev
Smith Kline G French Laboratories
1500 Spring Garden St.

Philadelphia, Pennsylvania 19101

Dear Dr. Loev,

It

pleasure to discuss your interest in THC
derivatives and I do hope that you can arrange to make
supplies available for BBC studies this fall.
was a

visited the University of the West
Indies in Kingston to review their cannabis study program
for NIMH. I met Professor W. R. Chan and Dr. K. E. Magnus,
and they described two unusual derivates of their hemp plant
which they have isolated. Their formulae and a citation of
This

last

week, I

a similar product isolated by Obata and Ishikawa ace attached
for your interest.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFtkt

�</text>
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      </file>
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          <elementContainer>
            <element elementId="50">
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        </elementSet>
      </elementSetContainer>
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                    <text>n ‘wwwvmmwvm

w w—wv

Juno 28, 1971

3r.

R. Mechanism

“threw Univarsity of Jerusalem
School of Pharmacy
P. 0. Box 517
Jerusalem, Israel

Dear Dr. Mechoulau:

Septratoly, I am sending you the available notes from our
present contract with Food and Drug Research Lacs. It would be
helpful to have another laboratory invostigcting this problem,
and I hape you can proceed.
I met Dr. Loev in Philadelphia two weeks ago, and we discussod
a systematic study of the TWEIJorivativo. Ho and his associates
cannot release the compound unless either they or we file an 1&amp;9
application with our FDA, an&amp; I left thou coasidorinﬁ their filing

the applicntion.

Moanwhilo I met Professor W. R. Chou at tho University of the
Indies and he reported isolating some now derivatives of
Jamaican hemp. The formulae are onclosod for your intorest.
West

I was pleased to know that your THC is stable and active. I
will uso the runnining matcrial in some experimental studies. The
information was most holpfhl for our relations with our chemists
My

best rognrds,

and my thanks

for your continued interact.

Sincoroly yours,
Fink, M.D.
Profbssor of Psychiatry

Max

MF:kt

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                    <text>June 22, 1971
Dr. Lawrence Bergner
Health Services Administration
185 Worth

New

Street

York, New York 10013

Dear Dr. Bergner:

In continuing our program of study of the role of narcotic
antagonists in opiate dependence, we are interested in assessing
the clinical use of a new narcotic antagonist, .-5050. In animal
trials. it is 8-10x as potent (on a mg basis) as naloxone with a
duration that is slightly longer. In contrast to the manufacturing
problems of naloxone, we have been assured by the manufacturer that
adequate supplies for clinical purposes can be made.
We

believe clinical

trials

with

M~5050

should be undertaken.

filed
toxicity studies adequate to
meet our standards prior to such trials. To file an IND we require
animal toxicology data. There are not available from either the
An IND

must be

and pro—clinical

manufacturer or his U.S. representatives.

have obtained proposals for the safety evaluation of M~5050
meet our needs, including single oral and intravenous
studies in rats, intravenous studies in dogs, oral administration
We

sufficient to
for

13 weeks to rats and to monkeys, from various laboratories.
principal proposals are from the Food and Drug Research
Laboratories of Maspeth, L.I. , and Woodard Research Corporation
of Herndon, Virginia.

two

The

To carry out these studies. prepare and file an IND, prepare
the necessary protocols, and undertake the initial human trials
using the heroin ”challenge” model will require funds for:

(1)
(2)

(3)

Animal toxicology

$31,500
7,500
Nursing and psychiatric 4,500

Consulting costs
support

$

43,500

This study will require 18-24 weeks for the animal toxicology;

for the

IND; and 10—12 weeks

for the

initial

6

weeks

heroin challenge data.

�Dr. Bergner

June 22, 1971

—2-

We trust these data
will be sufficient to provide the basis
for definitive clinical trials in opiate dependent
for trials in developing a long-acting formulation. subjects, and

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>.
W

.

June 21, 1971
Dr. Vincent Dole

Rockefeller University

New

York, New York

Dear Vince,

Enclosed

Commemive

is a capy of our latest
Pa ydu‘abuj.

summary

submitted to

at iron the point of view of numbers, the results are
unassuming. we may have successfully withdrawn 5-7 patients from
drug use, and these have been drug free for 6-9 months so far. We
have 63 patients now receiving cyclazocine (none on naloxone) for
3 months to 4e years, and they are doing as well as our alternately
treated methadone patients.
The technical issues for cyclazocine for daily administration
are resolved. We see a need for a long acting formulation, but
lack the energy and the facilities to develop this.
Looked

congratulations on the widespread acceptance and success
of your program, and on your election to the Academy.
My

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>June 21, 1971
Mr. Seymour Weingarten,

Plenum Publishing Corp.
227 West 17th Street
New York, New York 10011

Editor

Dear Seymour,

Separately I an returning the Miras' Manuscript. So far as
I can tell, both the subject and the extent of the descriptions
are useful additions to our literature. These sections, devoted
to biochemistry and aninel pharmacology, are interesting, and
seen to my untutored eye, to be well written and probably complete.
I would suggest you consult one

chemists for a

of the principal botanical

definitive evaluation,

and perhaps Dr. Mechoulam

Israel would accommodate you. Another nominee is Dr. Daniel
Efren of NIMH, an experienced pharmacologist who may also be able
to advise you.
Of

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>June 18, 1971
Dr. F. A. Clark, Jr.
A. H. Robina Company
1&amp;07 Cummings Drive

Richmond, Virginia 23220

Dear Fred,

It

was

kind of you to read our report on

fenfluranine so carefully.

EEG

profiles of

I agree that the choice of the word "tolerance" ig_unfortunate,
after reading the final report I have accepted your suggestions.
I am grateful to be able to correct my tent and replacement page: 13
are encloaed. These reflect a better discussion and should replace
page 13 in the earlier draft. I will correct the text in galley.
and

Our

clinical study of fenfluramine was unsatisfactory in that

observed the subjects weekly and depended on verbal reports and
recollections of interim events. Our subjects reported drowsiness
the first few days, waining by the end of 7-10 days, and not recurring
with gradual dosage increaaea. 0n cessation, l recollect 2 subjects
complaining of irritability and insomnia. This was insufficient
evidence and discontinued by us. We did start some patients on placebo
and transfer to fenfluramine. In retrospect, we should have started
some on fenfluranine and transferred to placebo. I did not comment
in my report because I did not "understand" that the various symptona
may form some kind of a syndrome.
we

I regret that Ricklee’

summary wee

presented in a prejudicial

way. While "Drug A ie no better than" is equivalent to ”Drug A was
ae good ae" as a summary of data showing no differences, the connotations
are indeed different and we should await the actual data. In his second
hie patients had weight lose and were sedated.
etudy, as you eunnarize
If this combination were anticipated by some obese patiente,
may be

it,

faeorahly received.

it

�{wwwwwlw

Dr. F. A. Clark,

It

has been

Jr.

-2-

June 18, 1971

impression that a wider trial of fenfluramine as
indicated, particularly since the many difficulties
with amphetamines. I would be pleased to read the NDA
material.
my

an anorexigenic was
Mhny

report.

thanks for your comments and help in improving
our fenfluramine

Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry
MF:kt

�</text>
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                  <elementText elementTextId="103462">
                    <text>June 17, 1971
Mrs. B. A. Shave
5319 Barton Road

North Ridgeville, Ohio 44035
Dear Mrs . Shave:

regret that I do not know of a program in Cleveland
using the narcotic antagonists. The closest is probably
at the University of Chicago where Dr. Jerome Jeffee has
been treating some patients with cyclazocine. I would
suggest you refer your inquiry to him.
I

Our program

City.

is limited to stated residents of

New

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

York

�</text>
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                  <elementText elementTextId="106254">
                    <text>Vi".-- ..”.1.—

.,v.,.....—.

«.mwﬁwﬂvwmwr

,

w-

~,

m. -w--wm‘mwm-‘nnmvyﬂw
,

.

4

,

~~.—w.

yum—1...“

n_m...n

,mwr

June 17, 1971
Dr.

Isrsel Kesselbrsnner

Kirby Manhattan Psychiatric Hospital

'Werd's Islend
New York, Row York 10035
Deer

Is,

Attached ere the curriculum vitaec and applications for
appointment of Drs. Michael A. Teylor and Robert H. Levine.
Both these men completed their residencies in July 1969
and now are completing two years of military service. They
will be in New York and ready to work on July 1. They will
be sppointed to the position of Instructor in the Departmentoof
Psychiatry, with the understanding that as soon as they have
their boerde they will be promoted to the position of Assistant

Professor.

examinations

We

anticipate that they will both teke their board

this winter.

They are capable teachers, clinicians, and researchers
I recommend them highly for positions at Kirby Manhattan
Psychiatric Hospital.

and

Sincerely yours,
Mex
_

MP:kt

H

.Wm.r-,&lt;

V

"r.

..

Fink, M.D.

Professor of Psychiatry

,

..» ._wv ...,

_.V._.V_v

�</text>
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                    <text>June 17, 1971
Dr. Jonathan 01 Cole
Boston State Hospital

Boston, Massachusetts 02146
Dear Jon,

Enclosed is an abstract (5 copies) for your consideration
for the 1972 APRA under the sub~group "Drugs and Brain Function
relevant to psychopharmncology."

Sincerely yours,
Fink, M.B.
Professor of Psychiatry

Max

�</text>
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                    <text>June 17, 1971
Dr. Michal A. Taylor
9309 Murillo Avenue

Oakland, California
Dear Mickey,
The

enclosed protocol

have an opportunity

Call

me

whon you

was

to defend
are in

sent out today and you will

it

New

this fall.

York.

Sincerely yours ,
Fink, NJ).
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>T
m

June 18, 1971
Dr. Jordan Scher, Director
The National Council on Drug Abuse
8 S. Michigan Ave., Suite 310
Chicago, Illinois 60603
Dear Dr. Schcr:

for your kind thoughts and nomination. While
I
in accord with the principles of the Council, I regret
that I have neither the time nor the energy to take on another
am

Thank you

committmont, and must decline your

In passing, I believe

invitation.

much can be done

to reduce the

particularly with the narcotic antagonists.
I would commend your attention to those substances as therapeutic
agents for addicted at all ages and as a prOphylectic agent.
Good luck in your efforts!
Opiate epidemic,

Sincerely yours,
Fink, £1.13.
Professor of Psychiatry
Max

ﬁrst:

�</text>
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                    <text>June 16, 1971
Dr. Louis

M.

Rousselot

Assistant Secretary of Defense
Washington, D.C. 20301

Dear Dr. Rousselot:
Thank you

for your letter of June 10.

clinical experience with the antagonists, cyclesocine and
naloxone, has been garnered chiefly from this laboratory, since 1965,
under contracts with the ﬂew York State Narcotic Addiction Control
Commission. I took the extraordinary step of writing as I did,
with the full knowledge that our full experience was not in the
The

literature.

it

may not be too late to suggest that military medical
and such advisers as you may wish to consult review the data
by a visit to this facility; As advisers I would suggest any of the

Perhaps

officers

leading officers at Lexington or Drs. Julian Villareal (Michigan),
Louis Harris (North Carolina), Jerome Jaffe (Chicago), John Kramer
(Irvine, California) and Albert Kurlsnd (Baltimore). These men atl
acquainted with some of the studies of the antagonists and could
advise your office.
Again, I thank you for your thoughts, and suggest you review
your conclusions.

Sincerely yours,
Max

Pink, M.D.

Professor of Psychiatry

MF:kt

bcc:

J. Jaffee

�</text>
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                    <text>Fwy—ww—“W wwv~mmwnm~m.

V

m

WW

,

W “WWW—rm,

Jun. 16, 1971
Dru.

W. Guy

and R. Bounce

Georg. Hashington Univcrsity

Biometric chorctory

1145 19th

Stroct, N.H..
Washington, D.C. 20036

Room

618

Dear 3111 and Ron,

Enclosed are eight RPR’: of our

EEG

studies of:

Doxcpin - Panoate vs. Hcl
Doxepin: Biocvcilability
028774
AER 1118
CP 1&amp;368
5 42,548
GPA 1714

01 ~ 63

In addition,

norhcdono, both
the doc: bank.
my

VD

could

clinical

file our studies of marijuanc,horoin

and KEG, should you

If so, please return

8 RPR

forms.

boot rosards.

Sincorcly yours,
Fink, M.D.
Professor of Psychiatry

Max

and

belicvc those useful in

�</text>
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                    <text>,‘m..rw-,rw-r “quvmwm.”my. Ar.w.w’.m.v,

v

.

;',-r.-«~

-mv=m.w~vgpuwmwrw.mv

y w» Vn'w-‘WI'TM‘V—I“Nun-"1

--

..

-.

wmwumuwnw”mm m-

-

I-v—

,

~

~vv .

.7

-

v

v

,ww—-

w-w

v:

.

T's—

June 14, 1971
Dr. Jon Heiser

U. S. Naval

Dear Dr. Heiser:

It was kind of you to bring your experiences with
physostignine to my attention. I had read your report and
congratulate your industry in reviewing the world literature.
"in

W"

Hospital

Oakland, California 94627

When we

worked with Ditran and

atropine,

Itil

and I were

impressed that the interaction of these drugs with chlorpromazine
was indeed dangerous, and sought unsuccessfhlly to make THA
available. But your suggestion of physostigmine is better.
I

trust

you

will continue this research after the navy.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

-

�</text>
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                    <text>“a

"mun

June 15, 1971
Mr. E. Drysdalo

New

State Narcotic Addiction
Control Commission

York

1855 Broadway

New

York, New York 10023

Dear Mr. Dryadalo:
We

are pleased to enclose copies of our report "Haloxonc

Treatment of Opiate Dependence”. This project was supported,
In part, with funds from the Now York State Narcotic Addiction
Control Commission.
Thank you

for your support.
Sincerely yours,
Max

Fink, M.D.

Profcolor of Psychiatry

MF:kt
one .

Fm WWW-W...“

�</text>
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                    <text>._.._ ,_.. .— 'v

rum”... WMw—nwwm

Wyn—w-

,

["__,,

!'—*"m“&gt;v—

www.-

"r

W,

“w.w.
.

,

.

ww""~V-W‘rw 1-ma’

,

~2—

Juno 14, 1971
10:

Dr. Nain Khazan
Mt. Sinai School

of Medicine

1800 Computer

Analysis of

New

For

IBM

York,

New York

EEG

- 3/29, 3/30, 5/5

8

5/5,

1971

(Please lake check payable to the Now Yotk Medical College and send
Max Fink.)

to the attention of Dr.

Wﬁ'ﬂmmm‘

,n—u—w—u—y—

m

MF:kt

$750.00

�</text>
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                    <text>l

i

June 14, 1971

i

Internal

Andover,

Revenue Service Center

Massachusetts 01812
Gentlemen:

Enclosed is our check for $184.90 which represents the
Federal Withholding Tex payment for the month of May 1970. We
are unable to deposit this in the usual manner since our
cards, which we have repeatedly requested, have not been sent
to us.

is

Fleece deposit to our account. Our identification number

11-215 7913.

Sincerely yours,
Fink, M.D.
Executive Director

Max

Mr:kt

�</text>
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                    <text>June 14, 1971
Dr. Jerome Levine

Parklaun Building

5600 Fischers Lane
Rockville, Maryland 20852
Dear
I.

.4...“

.
v,

.

-{wvnvuuw‘rwwn—

E

g

E

Jerry,
In our discussions at the

meetings, you expressed an
compound derived from
EEG
BA 1476, the 1,2-dinethylThe
data
on
tetrahydrocannabinol.
New York Academy of
THC,
was
of
the
analog
presented at
heptyl
Sciences meeting on cannabis, late last month. For further data
you may wish to obtain AD 342332 from the Federal Clearinghouse
on Scientific Information in Virginia.
ECDEU

interest in a potential psychoactive

Separately, one of my associates, Michael Taylor has filed
a grant application (Lactate Precipitated Anxiety in Psychopharnacology) to continue studies of lactate infusions in the
search for a better method to define anti-anxiety agents.
For some additional data on rating scale methods in the
aged, perhaps Carl would wish to consult Dr. Carl Eisdorfer at
Duke. I met him at a consultation last week and he impressed
me as knowledgeable about the problem.
Have a

successful

trip to Split.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>June 13, 1971
Dr. Jerome

Jaffe

Department of Psychiatry

University of Chicago
Chicago,

Illinois

Jerry,

Dear

The preliminary announcement of your appointment by the
President to lead the national effort against drug abuse was most
welcome here. I hope the appointment is made, and I wish you all
success. The undertaking is a great one and I am confident the nation
will follow your leadership willingly.

Since the reports in the New York Times last month of the
high rate of opiate use in our troops in Southeast Asia, I have become
additionally concerned about this horrendous aspect of this tragic war.
In considering the alternatives, I concluded that our clinical experience
with the antagonists (much of it unpublished) warranted some suggestions
which I shared with those authorities I could reach in Washington. I
write new in the hope that our experience may complement and re-enforce
your suggestions and recommendations.
aware

I consulting with the V.A. leaders in Washington, I became
were being entertained to rapidly return large numbers

thht pland

of addicted servicemen to their home communities, particularly to the
V.A. ceneters, for treatment programs focussed on methadone maintenance.
Such a rapid dispersion of the addicted drug users would be a tragic
error, for the V.A. centers are ill-equipped at present to care for
these men, and the users would provide multiple foci for local drug
use and experimentation as well as connections to enhance a drug traffic.
Such a course, based on dispersion, is the worst possible solution,
to homes
for
will return men who are unprepared for community

it

life,

without jobs and with inadequate counselling, and encourage the Spread
of addiction.

Every effort should be made to identify, detoxify and treat
in Asia, before they return home. One interesting suggestion
is to return the men to the States in slow ships, thus providing at
least 3—4 weeks of isolation, group therapy, counselling, and medication.

the

men

�“I1!-

new

..

Fun-["W—r

m

..
rmm

,v-w-u—m

m

Jaffe

Dr. Jerome

................ ...................June 13,
2

While I know every
and

traffic, educate the men,
tests, we would encourage

effort will

be made to

1971

restrict the

drug

identify users by urine and nalorphine
some specific applications of our esperience

with the antagonists. It now seems possible to provide prophylactic
programs, similar to the use of atabrine for malaria in an earlier war.
Opiate sependence has many of the characteristics of a contagious
disease, and I believe the daily administration of cyclazocine
would serve the same purpose today. Surely, id drug use is as widespread at the Times has reported, then an eXperiment in a small segment
of the 330,000 man army would be Iarranted.
Your experience with cyclazocine led to widespread
and in our early studies we confirmed your data.
The effects were exaggerated by the dosage schedules we then used. Since
January, 1970, we have inducted all our patients to 4 mg. cyclazocine
in 4 days with minimal discomfort, surely no greater than our patients

secondary

effects,

begin treatment with imipramine. For prophylaxis, 1—2
mg b.i.d.) should serve as an adequate deterrent.
The administration of a tablet twice a day at mealtime should serve
our purposes.
experience

who

each day (0.5-1.0

mg

-

have also discharged 6 patients from all care after 1.5 to
years on cyclazocine. These men remain drug-free, without 'craving'
We

4

after

3-9 months on no medication. Such a limited experience is
and not decisive, but sufficient to encourage further
trials. Surely, some military patients could be randomly assigned to
the antagonists, and were this experiment done carefully, an adequate
sample could be provided in a very short time. The men would have
similar histories of drug use, conditions of treatment and living,
etc. to those assigned to other regimens. Such an experiment would

interesting

answer many questions not only for the military, but for the nation as

well.

,
u...

In our discussions, and in the press, you have repeatedly
suggested that with the limited funds at your disposal in Illinois,
methadone was the treatment of choice. I agreed then, and I agree
today, that methadone provides the best answer for today. With
the crisin in Viet-Nam and the availability of funds from the military,
the V.A., and the P.H.S., surely the extensive clinical trials we
discussed should be undertaken as a logical back~up to the other programs

which you

will encourage.

For more than two years, I have supported and encoyraged
studies of the antagonists. As a national leader, I know you
will accept the repponsibility of leading the effort without the
parochialism so sadly evinced during the past few years by all of us.
I am delighted with your appointment, and I am encouraged that now I
can again turn my attentions to my laboratory studies.
expanded

With

all best

wishes for your personal success, I remain,
Most
Max

sincerely yours,
Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>June 13, 1971
Dear Andy,

I have reviewed your
arranged the following:

and

'

applications

and

have

Your appointment as Assistant Professor, effective
at an annual salary of $28,000 minimum (although

November 1, 1971

if my

letter

budgets are approved,

Your appointment

it will be

$30,000).

to the

an appropriate research
and the exact amount of
work
will
itself out in the

V.A.

at

staff position, the exact title is unclear,
salary

from them

next few

eeks.

is unclearn~ but that

By discussions with the V.A. authorities in washington, we
have a committment for a drug abuse treatment center for July, 1972;
and possibly for July, 1971. Alternatively, if I wish it, they will
entertain an application for a drug aabnse demonstration project
effective almost immediately. In either of these cases, the
research budget is likely to be very large, in the order of
$300,000 to 400,000, making your program the most heavily supported

one in the Division.

The petitions you have requested are signed and will be
processed through the medical college. Copies will be sent to you
as they are signed and approved.
The V.A. cannot make you a

full staff

memeber until
assured them that

you have a license to practice medicine. I
it was
your intention to take your examinations promptly and indicated that
you should be licensed by the end of 1972.
Keep

well,

and I look forward to your

joining

Sincerely yours,
Max

Fink,

M.D.

us

in

New

York.

�</text>
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                    <text>--.

rwmwa—w—n-

*M'wmﬂ‘ﬁm'e—WV'W‘WI

--

~

-

m.»-

.

r

,

Hal" W‘W"1wwn-".Vr’T-wwwvv——w&lt;

v—w'wm—WNﬁI—ﬁmmv—Hmm—IIV

..

whfwrw...

7

..._—...~

.w—m

‘—,‘

‘

we”..—

A

“WT—.mwwm-

-

~

“

June 11, 1971
w

-v‘r&gt;wwww'yww-w

Dr. Alfred M. Freedman
Chairman and Professor

Department of Psychiatry

.,

New York Medical College
5 East 102nd Street
thew York, New York 10029

~

nmw..—.

Dear A1,

.«mn—

.
V,

r
.7

V

I

.

ww'mvwwW-V'N—W

‘

s

wlmwmxwmwzrw“

For the past two years I have tried to find the time to carry
out my research and clinical committmants, serve the changing needs
of the Department, particularly in opiate dependence, to write the
henﬁsarticlea of the Division, and to write the books I would like
to write ~ on EEG and drugs, on the narcotic antagonists. and on ECT.
With the new services at Kirby and perhaps at.Mbntrose, I fear I will
not make any progress in summarizing my data.

I am writing to request a sabbatical year effective July 1. 1972.
I joined the Department in April 1966 and believe I will be eligible
at that time.
Such freedom will allow me to join the faculty of a university
center or research laboratory in Europe, where the reports could be
written (I hope) and I could learn more about psychopharmacology and
electrOphysiology. To make the necessary arrangements I will need
the school's approval now. 'This will permit me to make my connittments.
to work through our programs so they may be productive in my absence,
and to plan adequate coverage for my programs. I believe my staff is
adequate to maintain our programs without significant interruption.
Many

thanks.
Sincerely yours,

WW

wwr-wm—r

Max
wwmw

MF:kt
'Ta—n

n...

———.—~—v—Ww

Fink, M.D.

Professor of Psychiatry

‘

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                    <text>June 11, 1971
Dr. Mickncl Rosin
Droxel U31V0201€y

Philadelphia, Pennsylvania 1910‘
ncnr Dr. Nagin:

Thank you for your invitation to the 1971 Conference.
Since working with Dr. Itil in St. Louis in 1963—1966, I havn
not maintainod an active program of sleep scoring. Dr. Itil
baa unstained his intcrost, and I cuggclt you invite his
participation. Hioonddroao 1. Missouri Institute of Psychiatry.
5500 Arocnal Street, St. Louis. Missouri 63139.

Sinccroly yours,
Ha: Fink, M.D.

Pratt-cor of Psychiatry

Mrzkt

�</text>
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                    <text>_,

June 9, 1971
Dr.

Fritz

New

York, New York

A. Freyhsn

St. Vincent's Hospital

Dear

Fritz,

I an pleased to submit our report, ”Cyclasocine Treatment of
Opiate Dependence ~ A Progress Report”, for your consideration for
comprehensive Psychiatry. The opiate antagonists have been studied
since 1965, and despite such clear evidence that they are safe and
useful, see not used, often because some early students recall only
the side effects, observed by then when they were learning and when
their doses were excessive.
I have proposed to the President
a prophylactic agent in our troops in
for more efforts at developing a long
with adolescent papulstions should be

It

would be

helpful to

relates in the literature.
Thank you

have

that cyclasocine be tried as
Southeast Asia. There is need
acting formulation. Trials
undertaken.

this report

and the experience

for your consideration.
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mr:kt

it

-—

W'W

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                    <text>June 9, 1971
M188

Donohus

Clcsaificd

Adv. Sec.

New

York Times

New

York,

229 Want 43rd

New

Scrcct

York

Dear Miss Donahue:

This is to confirm ad placed by telephone today for Exccucive
Secretary. Thu ad in to run for three days, June 11, 12 and 13, 1971,
at a coat of $288.40.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>June 9, 1971
Mr. Neil Waldnan
Manager, Film 5 Video Tape Library

WCBS—TV

524 West 57th Street
New York, New York 10019
Dear Mr. Whldman:

I would be interested in obtaining a copy of a film aired
on the Walter Cronkheit Evening News on June 4, 1971. The film
was taped in my laboratories at New York Medical College by
Mr.

Earl Ubell.

In addition, would it be possible to obtain a copy of the
film which preceded the above film of the Senate Hearings, as a
member of my staff was interviewed.
We

would appreciate receiving copies of the above films

in order that they

it

may become

a part of our permanent

files.

Please let me know the cost involved and whether or not
is possible to obtain copies of these films.
Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>June 8, 1971
Mr. Vernon 3. Brooks

Section Editor, Neurobiology
‘Depsrtesnt of Physiology
New

York Medical College

New

York,

1 East 106th

New

Street

York 10029

Dear Vernon,

I have examined the two reports A142-l and A143-l, anticipating
an evaluation for the J.A.P. Unfortunately, both reports are focussed
on the evoked response, a technic with which I an familiar, but not
to a degree to be critical. I an returning these reports with the

suggestion that others more qualified than me rsvfevishethstistesles
would be Roy John, Charles Shsgass (Temple Univ.), Ed Domino (Michigan)
or Bert Rosner (Yale).

In A143, I read the section on scalp EEG. The samples presented
are interesting examples of the probable EEG differences between
cycloproprane and the group methoxyflurane, ethrsne and ether.
Indeed, the sample clearly shows a difference in spindling and in
dominant frequency among the three beta procedures. But the presenta—
tion lacks any quantification; there is no accommodation for differences
in the pre~drug EEG record; and there is no effort to relate the
differences in evoked potential to the differences in resting EEG
record. Even recognising the unique nature of this study, these
lacks (in 1971) show a deficiency which would require much compensation
from the remainder of the report to recommend its publication.

Incidentally, Table I seems misplaced.
I regret I cannot be of more specific help, but I cannot do
the journal or the authors justice. Thanks for thinking of me.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

nfzkt

�</text>
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                  <elementText elementTextId="106269">
                    <text>June 8, 1971
Dr. Norman
Chen.

Pitts

Pfizer

6

Co.

Groton, Connecticut

Dear Norm,

Enclosed are a few copies of revised pages of our recent

report,

”EEG

Profile Analysis of

Pamoete and B61 Formulations”.

Doxepin:

III.

Comparison of

I would appreciate your secretary
replacing the appropriate pages in your copies.
I an also enclosing our

compound which an EEG

two

reports

on GP&amp;1299, the Geigy

profile is related to doxepin.

Your report to the ECDEU was most interesting and I will
share the material presented by Dr. Saleburg with Don Shapiro
and be in touch with Dr. Saleburg if at all feasible.
My

best.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszt

�</text>
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                    <text>June 5, 1971
Dr. Thomas williams
National Institute of Mental Health
Chevy Cahse, Maryland

Dear Tom,

Friday, June

3 p.m. for you, and we
5 East 102
me

18

is fine for

me.

I have blocked off

can work as long as you wish.

Street.

at

My

from

Please join

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>June 5, 1971
Dr. Joseph Buckley
School of Pharmacy

University of Pittsburgh

Pittsburgh, Pa.

Dear Dr. Buckley,

recent issue of the Blue Sheet brought to my attention
new psychotropic drugs. For many years we have been
attempting to define the clinical activity of psychotropic drugs
by their effects on the scalp recorded himan EEG in volunteer
subjects. Recently, we have applied these methods to the study of
novel, number compounds from a variety of manufacturers with some
success.
A

your studies of

I am interested in your methods and would be grateful for
a copy of any general descriptihn of your methods and the types of
compounds for which these methods have been most successful.
Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>...._T_.‘,.i

June 5, 1971
Dr. Monique Broude

National Institute of Mental Bealth
5400 Wisconsin Avenue

Chevy Chase, Maryland

Dear Monique,

Following our conversation yesterday, I am writing to
confirm our understanding regarding our chronic marijuana study.
The advisorv committee on psychotomimetics has recommended that
we not allow our Volunteer subjects to smoke marijuana daily for
more than seven consecutive days without an intervening 7 day

rest period.

This recommendation seems consistent with the experience
of the committee and we will modify the protocol in the experimental
design. Instead of "Subjects will smoke one active cigarette on each
of 21 consecutive days" we will plan,
Each (subject mu woke one active agate/ac, on each 06
mean comccuzéve dayé. Tame. mu. be an intenvcning week 05 daily
acpomténg, and in the almanac of {arithdxczzwai on Accondalw bywwtmﬁ,
each “abject mitt again. maize one active. docket/ta. 5011. muen consecutive.
(149%. T MA we be. done, with the. initial. gaoup 05 8 Aubjccm.

Mudg

1.5 $522,450.

13w.

Accond

«tea/m one

ngup

05. 8

without went camequmces,

vo£untems

thh

Achedwee and 14 dag» 055; Impending 14 dayb

repeated.

spillage,

a 14

if,

deg

we

W

active dwg

no consequence» cue

For these two phases, and allowing for some dropouts and
will require 400 grams marijuana with a rated THC-delta-B

we

content of 1.52.
In the event that the placebo marijuana is available, I would
like to modify the above protocol as follows:

—.

n-

«

n

K

..-r—

�Dr. Monique Brande 00.000.00.00.

2 OOOOOOOOOOIOIOOOOIJune

5’ 1971

Them». «m be an (Mam-2mg week when the
. .
buijC/tb will make a placebo mmjuan ulgamotte, each contaimng
”

no

active manual, and in the absence

If this modification is acceptable,

placebo marijuana.

we

05.

would request 200 grams of

Your cooperation is very much appreciated, and we
pleased to be able to undertake these studies, which seem so
for the national interest. We have delayed the onset of the
by one week, having scheduled the first subjects for Monday,
and trust that these supplies may be available by that date.
Many

are
important

study
June 14

thanks.
Sincerely yours,
Fink, }€.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>P

"W ,-

——w ———~~-r»

'vw‘

w .._- -

w“,warm...“
,,

..

.W

w- . w-n

——

,

June 2, 1970

Prof. Dr. P. Kielholz
Peychiatrieahe Universitateklinik Basel
switaerland
Dear Dr. Kielholz,
Thank you for your letter of’May 28. I am sorry that
misunderstood
the program outline. I have invited Dr. Ladewig
you

to present during the symposium, on the topic of‘VAmphetamine

and Hallucinogen Dependence in Europe", as a joint presentation
with Dr. Battegay. I wrote to him on May 25, extending the formal
invitation of the Program Committee chairman, Dr. Vinar. By now,
he should have received the

invitation.

to Dr. Vinar indioating your acceptance
I will write
and co—sympoeium
to summarize the

of’the responsibility

at the Plenary session.

with you.

I

symposium

look forward to seeing you in Prague and working

Sincerely yours,
Fink, M. D.
ProfEBeor of.Peyohiatry
Max

me

�</text>
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                    <text>June 1, 1971

Dr. S. Clyde Strickland
Merck. Sharp &amp; Dohme Research Laboratories
West Point, Pennsylvania
Dear Clyde,

In answer to your letter of May 19, the data on lvalphaacetylmethadol was sent as a 'progreas report‘, and we do not plan
to publish it in this form. we have an additional six patients in
progress and as soon as our numbers are adequate and the data

'reliable',

we

hope to publish.

higher incidence of sﬁde
be
our inexperience in selecting the
effects. In part, it may
and
we
may have undervtreated leading to
individualized dosages,
some 'withdrewal' symptoms. Or, what appears more likely to us, the
We

do

not

know why we have a

agonistic effects, similar to cyclazocine.
The patients know they are getting a different drug, for
they receive it only on alternate days.

compound has some

for the some symptoms with methadone, we have not
observed them; but also, we have done little dosage experimenting.
My best regards, and my thanks to Gil for the lunch in A.C.
As

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>.

m.

.w...

—..

,_

-w

..

.r‘-,.n.w.~7.—l....-

V

—.....w

May

,m, up", v

’HW&lt;

,nv‘nwﬂ'vml'r.

.n mp. ...

Ivar-nzy. ,7"

29, 1971

Dear John,

I am delighted that you will be able to assist us in
developing the program for a heroin delivery system. We would
like to have you join us June 22~23 in New York, and we will plan
the necessary steps in developing the project.
The

trip to

England

is in the planning stage and
it is necessary during

should be able to decide what and whether
your visit here.

we

and

FDA

project.

Next week, we have appointments with the BNDD, NIMH
to clear the politics and medical essentials of the

In the meanwhile, any literature or data that you have
with regard to experiences with heroin, heroin maintenance,
heroin tolerance, and its pharmacology, should be collected
and the citations brought with you when we meet.

If

you

My

best regards.

will stay with us,

we

would be pleased.

Sincerely yours,
Max

.
rm»...

CNM
‘

Fink,

M.D.

»

_-_.- w-r-

~

W'w‘i'.1‘

�</text>
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                    <text>». ‘7

‘

. _.w_.~..—.(.:~W

.—

—-W

m

v—mmr—w—r

'n-z-r

"F's!“-

May

Dr. Vorman E.
Pfizer 8 Co.

25, 1970

Pitts

Croton, Connecticut
Dear Horn,

\

associates, Hrs. Simeon and Spero, anJ‘I are
agreeable to having the reprints of our report,'A Comparison of
Hoxepin adn Chlordiazepoxide in the Therapy of Anxiety' distributed
to physicians by your professional representatives in the course
of their visits to physicians; or in the course of their replies
to inquiries.l/ we would request, however, that the article not
be used in the usual promotional material or quoted out of context
as a general endorsement of this product.
Ky

need,

You may,

of course, purchase the reprints which

bony thanks

you may

for your cooperation in this study, and
be useful to your representatives.

trust that the reprints will

Sincerely yours,
For Fink, N.D.

Professor of Psychiatry

mf/

I

�</text>
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                    <text>May 2'4 ,

1971

Dr. Russell Memos
Mmylmd Psydiiatzic Institute
Baltirmre, Maryland 21201

momma,
E‘. lu76 most interesting, emd
by Domino , suggestive of a

I found the discussions of

as the evidence was presented

potentially useful treatment of depression. I hope sate studies
may be

undertaken.

editing an issue of Swim in
I would appreciate the reprints
EEG
changes in patients with implmted
of your reports of the
electrodes. If you wish to publish these findings , I would
be pleased to include this data. The reports are due by the
end of June to meat om deadline.

I neutimed, I
Psydliatry dedicated to
As

My

am

ECT.

best regards .
Sincerely yours

,

Pink, 34.1).
Professor of Psychiatry

Max

�</text>
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                    <text>Hay

2’4

, 1971

Dr. Rafael Mechculam
School of Pharmacy

Hebrew University

P. O. Box 517

Jenxsslem, Israel
Dear Dr. Meduﬂam:

Itwas agreat pleasure forustohearcfymn‘vnﬁcwith
we are mtt grateful for your assistance in our

cannabis, and

analytic problems.

discussed I am enclosing a swam cf the clinical
the narcotic antagonists, and sore reports from which ym
can obtain the citations for the chenical reports. We believe that
a long acting antagmist is a logical and useful way to treat opiate
dependence and have sought to encourage the develoment of such a
fomzlatim. Should you or your associates be interested in this
problem, we mmld be pleased to go into the details and make
available the notes frcm our present contract with Food and Drug
eRseardi Inc.

data

As we

on

new theoretical interest is the data presented on EA 11476 ,
the l, 2 dinethyl heptyl melon of tetmhydmcarmabinol. Dr. Russo 1
Monroe shand me scare EEG records of the early studies in monkeys,
and these darmstrated a persistent, high voltage slow wave (3 5 cps)
pattern. This EEG pattern in awake subjects, is characteristic of
the post-convulsive therapy state and is associated with behavioral
inpmvement in depression. I am enclosing some early renorts, and
would encourage you (and/or SK?) to extend the trials‘of EA 11:76 in
um.
I an also mclcsing a copy of your report as you requested.
Of

Again, our thanks for your

disassicn.

Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

HF :kt

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        <authentication>0155d97726b8812172e7a5722f79e5fa</authentication>
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                  <elementText elementTextId="103469">
                    <text>61W

May

2a. 1971

for Federal Scimtific

and Tedmical Information
5285 Port Royal Md

Springfield, Virginia

mm:
We

22151

desire to obtain the following mutants:
AD

718-83:

Mew of Biomdioal Effects of
Parijuma in Man in a Fﬁlitary

A

Ihvizmnt.
AD

m

3&amp;2332:

A

W

and 2233

Dec. 1977)

report
(U)

on EA M76

ask for a list of other wailable
(the 1 2~dimathylwﬁeptyl analog of
temhydrocmmahiml)?
In addition
on EA

11076

may we

waxk you.
Sincerely yours ,
Mm:

Fink, RD.

Professor of Psychiatry

34.th

�</text>
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                    <text>.— w&gt;=vw-r-:Nn'r—"-vv e-w-T

May

20, 1971

Dr. Diana Johnson
Biomedical Information Scientist
University of California, Los Angeles
The Center for the Health Sciences
Los Angeles, California 90024
Dear Dr. Johnson:

Enclosed are the corrections you requested. Is there any
reason why you would not use the author~prepared abstract? I

would

prefer

it

to the enclosed version.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

NF:kt

“an..."

.

V

(“yawn—”w no

-.r mum—"p“

�«wk;

The

‘v

Vw—

.~

7;»

'r“

7.7.7.

~...v

..

A..—w. war—w 1-—-.

.

:--

—'—-—m;-mumg.:_

nu annrnqwu-w. ._W«yp,— vyy-

-

-.v~.7r.-,-r..—_«

tn“.

-

7,7,

,

.

.

wy

ru— 1n»-

therapeutic effectiveness of unilateral electrode placement

and multiple
R.

;- -..

seizures in convulsive therapy has been studied

Dornbush, S.

Feldstein,

R. Abrams and

J.

by

M.

Fink,

Volavka (New York), with

the goal of reducing confusion and other side effects of such therapy
while maintaining

its beneficial action.

Seizures with unilateral

electrode placements results in less clouding of consciousness, earlier
waking, and less memory impairment than bitemporal placement.

bilateral

ECT

produces

its

Conventional

major impact on auditory verbal memory,

short~term memory is influenced

little

by

either unilateral

bilateral

and

Visual

bilateral

result in prolonged EEG
slowing with larger amplitudes over the left hemisphere, while unilateral
ECT produces higher amplitudes on the treated (right) side.
Bilateral
ECT is usually clinically more effective and faster.
There is a persistent
advantage to bilateral ECT for the first 4 treatments, but little difference
thereafter; an equivalent clinical effect was seen for 5 unilateral versus 4

ECT.

The EEG

seizures produced

bilateral treatments.

by

The use of

multiple

ECT

ECTS, 4

or

6

hyperoxygenation, appears to have approximately the same
as the same number of single treatments.
ECT

It

per day, under

effect

was concluded

that unilateral

is almost as efective as bilateral treatment, withoﬁttthe

memory

loss.

on memory

accompanying

Further study of multiple treatments are necessary.

has been thought that treatment effectiveness

but the persistence of slow

wave

is related to

activity appears to

memory

It
loss,

be more important.

V

7-;

�</text>
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                    <text>May

20, 1971

Dr. Bruce H. Mead, Director

Professional Services

Laboratories
Nutley, New Jersey 07110
Roche

Dear Dr. Medd:

I

Thank you

Itil.
will be of interest to the university chairman

for the

am sure there
who received the

managrsph on E36 and the

reprint

by

mailing.

I know Dr. Itil's work very well, as we were co~workers during
years in St. Louis. Recently, we collaborated in an exhibit on
combined drugs in schizophrenia at the APA, and this exposure was

my

most

interesting.

With your

interest in

EEG,

perhaps you would

connider sn exhibit of the methods of quantitative electroencephalography
as another way of getting the message to the psychiatric profession.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>May

20, 1971

Dr. Jan Volavka

Department of Psychiatry
York Medical College

New
New

York, New York

Dear Voita,

Effective April 1, 1971 you will receive part of your salary
State instead of a portion from NYMC. The state rate
is $680.70/2 wcoks, or $12,500/year. The not increase will be
$1,500 accruing to you in View of the special problems in attending
from New York

Kirby.

Enclosed are two checks grossing $1,345.96 and $480.70

representing the period from 4/1/71 to 5/1/71.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
M!:kt

�</text>
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                    <text>May

19, 1971

Dr. Pedro Geztenege»
Department of Psychiatry

Metropolitan Hospital
1901 First Avenue
York, New York

New

Dear Pedro,

Enclosed is e check from the New York State representing
pert of your celery. Renceforth you will receive part from
New York State and part from New York Medical College at such
e rate that there will be‘a net increment to you of $1,000 (or
slightly more) for period beginning April 15, 1971.
Encloaed

is check for

$210.23

net, gross $269.23.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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