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                    <text>February 19, 1971
Dra. Rhea Dornbush and
New
New

Stanley Feldsteiu

York Medical College
York, New York

Dear Rhea and

Stanley,
seminars in Psychiatry, a

new

quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. 1 am pleased you have accepted the invitation
to contribute the report on "Memory and ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

To meet the publishers deadline, can
you make a
by the end of June?

draft available

It is a policy of the seminars to re—issue reports of general
interest in hard cover. If we are successful (and
I
the
volume to have widespread interest), the volume shouldanticipate
then be
cited both as a periodical and as a book. assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Max

Pink, 5.9.

Professor of Psychiatry

Mszt

�</text>
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                    <text>w.

.w

w-~r

v

WWF‘WW

emu-W

Mfr?

February 19, 1971
Dr. Richard H. Rech

Associate Professor of Pharmacology
Dartmouth Medical School
New Hampshire 03755

Hanover,

Dear Dick,

write a useful review of EEG and drugs is probably a
idea, although I did my best in 1967-68 in the review I
prepared for the Efren book and for Henry Elliott's Annual
good

Review of Pharmacology,

rewrite the dissociation-association hypothesis seems
pointless, since the material of 1966 is published and not yet
superseded. To report the material presented in Aspen is less
useful, since we did not have either a consensus nor a clear
issue about which sufficient data were available. Killam, John,
Adey and others are making connections between the AER and correct
and incorrect decisions - some distance from mood, thought and
To

other processes with which association—dissociation theory has
to deal.
In sum, the idea

WW‘IM'WWWN'Lty

unI-x'w

-.:.ur"N'

a—nwma-

'nvtr‘rlwwaw-mwamm‘J.

To

may

be

interesting but

I do not see a

central issue that is needed to spark a viable volume. The
"fundamental relationships between the EEG and functional CNS
changes induced by drugs" is grand and unfocussed at this time,
and probably very difficult to focus.

It

in

Aspen and the memories sustain me through the
in the most filthy of cities. Don't they
need professors in ecologically clean Dartmouth?
was fun

most dreary

of

days

Sincerely yours,
an

p:.-~n.-rzuv.c~

Max

.u—wq

w".

'

-r'x:~mnu1«..

":1

.

Fink, M.D.

Professor of Psychiatry

r,

MF:kt

�</text>
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                    <text>.

w.

.g._.,—._—Y,,,,.u-

m.”

a“!

raw-ma.

-&gt;w~:~'—‘1'J\WT..M-.W*‘~.W

n,

,

,_

:n,

W‘uv'

wwwiw

a»,

7......"

n

February 19, 1971

.0.

noun».

army-7:.

Dr. Walter Essman

Department of Psychology
Queen's College

Flushing,

New

York

Dear Walt,

seminars in Psychiatry, a new quarterly publication edited
by Milton Greenblatt and Ernest Hartmann, has suggested that the
to Recent Progress in
first issue of 1972 (February) be devoted
have
am
accepted the invitation
I
Convulsive Therapy.
pleased you
Seizures". The notes in
of
"Biochemistry
on
to contribute the report

the outline are suggestions, and you are free to expand on the topic

as you wish.

The volume

200-300

is usually

typescript pages.

120*160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

meet the publishers deadline, can you make a
by the end of June?
To

draft available

a policy of the seminars to re~issue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

It is
I

hope you can

join us.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

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                    <text>w-

-Fr-uu-v...u

new."

u.

February 19, 1971
Dr. Ralph D.

Miller

Research Director

Commission of Inqqiry into the
Non-Medical Use of Drugs

Fuller Building
75 Albert Street

Ottawa, Canada
Dear Ralph,

"If wishes were horses, beggars would ride."
It is easy to bring you up to date. With regard to Athens,

'1
v-

data in volunteers smoking 1.5 gms,
0.5 gm or 0.0
variety 12.5, 7.5, 0.0 THC) in 2 minutes.
Found an EEG effect with rapid onset (less than 2 minutes) and waning by
8-10 minutes. Tried some samples of THC concentrate in a short cigarette
(30 min.) in 30 seconds. Great EEG changes! To do study needed slightly
larger supply of concentrate than I had on hand. Call NIMH in November.
Committees met, powers-that-be considered and decided that concentrate for
animals only, not for man. Raised a bit of a storm, and after 2 1/2 months,
was told would get supply last week. Still waiting.
In

YEWFIWJME’T

«a
N

'F
‘I'JY-

‘19

‘Y

'51"

in

("lewm‘

W53.

"ﬁ'iﬂfatm

‘

New

Was

Waiting.
17.4EOIVP."'I"WA‘WWW"

York,

we

if

we

analyzed our

gm MJ (NIMH

asked

would

EEG

8

like to see Jamaican group. Said “yes”.

So, come visit. Will be glad to show you our data.
studies will be on-going when you visit.

raw

Hope you do

.4
s~

things better in Canada.

5'-

Sincerely yours,

wwrs

X".¥.-‘M.

”.mpwmw—mvv

Fink, M.D.
Professor of Psychiatry

Max
‘l
strut-M

Mszt
WMV'VOG-ﬁ

may

~

‘=

=W71HW

It”?

we

were able to re-negotiate the conditions of our contract between September
and January; wrote to Athens to begin the study in March; and await a
reply. [Negotiation hang-ups usual administrative in Washington.]

Perhaps the

�</text>
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                    <text>February 19, 1971
Mr. Demetri P. Kenellakos

Stanford Research Institute
Park, California 94025

Menlo

Dear Mr. Kanellakos,
Thank you for your survey of the literature on ”Voluntary
differences
It is clearbethat
Improvement of Individual Performance".
but
defined
TM
can
and
other
states
between the measures during
defined.
be
to
their regularity and significance are yet
I found your review most
Many

thanks.

If

helpful.

you can, give

my

regards to

Lee

Otis.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>February 19, 1971
Mr. Robert
241 Paxton

Paterson 3,

Cortese

Street
New

Jersey

Dear Mr. Cortese:

Unfortunately, we do not have the material to treat patients
outside Metropolitan Hospital in New York City. The treatment is
on methadone
still experimental. I would suggest you continue
and
commercially available.
until a narcotic antagonist is perfected
Sincerely yours,
Pink, “.0.
Professor of Psychiatry

Max

Mszt

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                    <text>February 19, 1971

4

0f

you go send an the

articlc

from Mexico City.

«in; to find the programs and so

tried a press

'ariety in the reports is intartsting.

~'es are continuing, although slowly. 'We have
father
:9 square to Motroyolitan and so see yourwork
I
and
the
hope
$g.no of your agpointnant,

Sincsroly yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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'

1
5
v
-

'
-:z-

«Hrs—x

-

February 19, 1971
Dr. Richard H. Rech

Associate Professor of Pharmacology

Dartmouth Medical School
‘Hanover, New Hampshire 03755
Dear Dick,

write a useful review of EEG and drugs is probably a
good idea, although I did my best in 1967-68 in the review I
prepared for the Efren book and for Henry Elliott's Annual
To

Review of Pharmacology.

rewrite the dissociation-association hypothesis seems
pointless, since the material of 1966 is published and not yet
superseded. To report the material presented in Aspen is less
useful, since we did not have either a consensus nor a clear
issue about which sufficient data were available. Killam, John,
Adey and others are making connections between the AER and correct
and incorrect decisions - some distance from mood, thought and
other processes with which association-dissociation theory has
to deal.
To

In sum, the idea may be interesting but I do not see a
central issue that is needed to spark a viable volume. The
"fundamental relationships between the EEG and functional CKS
changes induced by drugs” is grand and unfocussed at this time,
and probably very difficult to focus.

It

in ASpen and the memories sustain me through the
of days in the most filthy of cities. Don't they
need professors in ecologically clean Dartmouth?
was fun

most dreary

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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«

47.1w.

ﬁrmu’rr‘u',

&lt;——,~

brawn—“W

.

ﬁu-r-z

M's--

.-_‘..&lt;r,-—

February 19, 1971
Mr.

J.

Bondoux

Manager, Systems DeveloPment

Biochemical Procedures
12020 Chandiey Blvd.
North Holywood, California 91607
Dear Mr. Bondoux:

their

you

Both cyclazocine and naloxone are experimental drugs. For
chemistry, availability outside our laboratories, I suggest

write the manufacturer:
Endo
1000

Laboratories
Stewart Ave.

Garden

City,

(naloxone)

New York

Sterling-WinthroP Research

Institute

Rensselaer,

(cyclazocine)

New York

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                <elementTextContainer>
                  <elementText elementTextId="103417">
                    <text>w"

w.—-- -—-- )1"

uswow-r w
.

»

w-im

.

v

.t

_

M

n .t

,_.

t .. .

.

.

.~4

r‘ 'W‘IV—r up
.,

_

1—7.V—V.—.-v
n

W w,,,,....,.,.

.,.hr,.~.
.

.

v“...

.. .

.‘

,

. w.»

.7
,

~

w:

,

mast-o‘—

February 19, 1971
Mr. Robert

Cortese

Paxton Street
Paterson 3, New Jersey

.241

‘Dear Mr.

Cortese:

Unfortunately, we do not have the material to treat patients
outside Metropolitan Hospital in New York City. The treatment is
on methadone
still experimental. I would suggest you continue
until a narcotic antagonist is perfected and commercially available.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

�</text>
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                    <text>February 18, 1971
~

i

The Reverend Phylemon Titus
3991

Fourteenth

Avenue

Detroit, Michigan
Dear Reverend

‘

i

48208

Titus:

Your kind offer of the Opportunity to establish a treatment
unit at the Fourteenth Avenue Methodist Church in Detroit is most
kind and reaponsive to our announcement.

is a non-profit fund raising group hoping to support
medical research, such as we outlined. At present, we are not
in need of either patients or a place to work, but need the funds
necessary to stimulate the research scientists to make the special
efforts necessary to make the narcotic antagonists freely available.
FADA

I thank you

for your

letter to the leaders of

most kind

$ADA.

offer,'and have forwarded your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
cc:

FADA

�</text>
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                    <text>February 17, 1971
A. Hargreaves, Ph.D.
The Langley Porter Neuropsychiatric
401 Parnassus Avenue

Dr.

Wm.

San Francisco,
Dear

California

Institute

94122

Bill,

Stanley, Rhea Dornbush, Jan Volavka, Richard Abrams and I have read
and discussed your report at length. It is an interesting suggestion,
that the memory and EEG effects may require hours to "mature". In one
group of patients we did try to assess memory changes at 3 hours postseizure but the study was incomplete, and we are unable to contribute
to the hypothesis from these data.
Our recent EEG data does not allow a test of the suggestion. We are
writing the protocol for a new study, however, and if we are able, will
include some serial EEG recordings to try to answer the question.
Thanks again

for the opportunity to read this report.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>February 11, 1971
Dr. David R. Metcalf

University of Colorado Medical Center
4200 East Ninth Syenue

Denver, Colorado 80220
Dear Dave,

Enclosed is an abstract for your consideration for the
1971 Annual Meeting of the American_EEG Society. I am not

confident that this application of quantitative EEG is sufficiently
"basic" to interest the members, but it is a reflection of the
EEG.
progress made in the quantification of the
Perhaps a workshOp on present applications of quantitative
EEG may

be useful.

It

was fun

in Aspen.
Sincerely yours,
Fink, E’ioDo
Professor of Psychiatry

MEX

Mszt

�</text>
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                    <text>-n.-

February 11, 1971
Mr.
7

Charles Chidester

Quaker Lane

Enfield, Connecticut
Dear Chuck,

vzmm

MW

‘gn‘/W.W'"VWDHIW'JM'1"

My associates returned from your laboratories pleased that
the equipment seemed to be in order. As part of their enthusiasm,
and in conjunction with some improvements in the ways we are
recording EEG records here, they have written a set of guidelines
which may be helpful. I would appreciate your reading these with
the equipment at hand and checking the sequence of procedures.

UR-7007

Dr. East

visited yesterday

in the prison

and

and

is proposing

this will probably

be our

a study

first

of

study.

Speak to you soon.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt
cc:

A. P.

Berger,

M.D.

P.S. Separately Mr. Pavel is sending you the cables he promised
for the oscilloscoPe.

�</text>
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                    <text>February 11, 1971

Editio Cantor

KG

796 Aulendorﬁ
Wﬁrttenburg, West Germany

Gentlemen:

Please establish a subscription to Aazneimitte£6onbchung,
effective January 1, 1971, addressed to:
Max

39

Fink,

M.D.

Arleigh

Great Neck,
Payment

Road
New

s

York 11021

will follow billing in dollars.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

_A

Ahmmn.g.$_

(x

�</text>
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                    <text>February
Dr. Ralph

W.

ll,

1971

Richter

Director, Neurology Department

Harlem Hospital Center
135th Street and Lenox Avenue
New York, New York 10037

Dear Dr. Richter:

principal reports from this laboratory on the subject
of "Neurophysiology of Opiate Addiction" are enclosed. These will
provide the basis for the presentations.
I look forward to participating in the AAN didactic sessions on
April 28 at the New York Hilton. While it may be too late to suggest
a change in the program, you may be ill advised in inviting a presentation
by Dr. J. Benson-Gerber, whose hostility to biological approaches is so
will known, as to lead to a degeneration of the symposium section of
The

the meeting.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>w-u‘mm‘w

w-..

February 11, 1971
Mr. Timothy E.
Box 1459

Quill,

Amherst College

Amherst, hassachusetts 01002
Dear Mr.

Quill:

available
for this summer.
are planning a series of experiments, however,
in which volunteer males are asked to take various psychoactive
drugs, either on dingle dose or daily doses for 3 weeks. We are
interested in recording changes in behavior, brain waves and memory.
Volunteers are paid by the project.
Regrettably

If

we

We

you may wish
Irwin (212 - 369-7900,

do not have summer fellowships

to volunteer, I suggest
ext. 249) in late May.

you

call

Mr.

Sincerely yours,
Fink, M.U.
Professor of Psychiatry

Max

Mszt

Peter

�</text>
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Ir.

Richard Brezinski
Convention Manager
Arizona Biltmore Hotel
Phoenix, Arizona
Dear Mr. Brezinski:

are interested in holding our meeting at the Biltmore,
but the planning group will be unable to make a final reonmmendation
until late this spring. In the event the decision is affirmative,
We

I

will call your office.

Sincerely yours,
Max

Fink,

M.D.

Executive Director

Mszt

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                    <text>February 11, 1971
Dr. Margaret

J. Giannini

Director, Mental Retardation Center
1249 Fifth Avenue

New

York, New York 10029

Dear Dr. Giannini:
The recent announcement of the N.Y.M.C. Seminar on Mental
Retardation in conjunction with the University of Athens interests
me. It is probable that some of us may be in Athens in March at
the time of the meetings. May we have a copy of the preliminary
program when it is available?
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>.m-an

»

-

&lt;1“

—,.

leﬂrpﬂymm-‘Ww

T

February 10, 1971
-

""371"

imv‘vr-rm’ml‘

g
gurkn’

Dr. Jerome Levine

Psychopharmacology Research Branch

National Institute of Mental Health
5454
Wisconsin

Chevy Chase, Maryland 20015

Dear

Jerry,

..—r

RE:

MH~13358~05

,-,~—.

&lt;.
’"'

ﬁi'n'rmvr‘wwmwﬂ'!‘

In the event that MH—13358~05 is funded effective
1,
at an annual rate of $60,000, I would request the June
following
reallocations of direct costs to maximize the use of our
facility.
Personnel
$39,700
1971,

Consultant
500
Supplies (incl. electronics)5,800
Travel
2,000
Volunteer fees
6,300

Y-«vac

rW'erv-wwz‘

Other

Publications

l"71"W“"’

IBM

.w

t-‘r

pm.

600

6,000

1800 Maintenance
and Insurance
5400

_,5,ut

Many

thanks.
Sincerely yours,
Max Fink. M.D.
Professor of Psychiatry

MF:kt

�</text>
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                    <text>§“v‘vmwmrv

‘

'v'rav'v u

To:

Dr. Fanaterhaim

FROM:

Dr.

Max

DATE:

February 10, 1971

Fink

Freshman Lectures 1971

SUBJECT:

I will be pleased to discuss Brain Function and Behavior
with the Freshman medical students on May 10 and May 17, from
11 a.m. to 12:50 p.m. I plan to describe the following:
1.

Brain measures,

EEG;

vigilance, trauma

hallucinogens, opiates and
alcohol; clues to a therapy of addiction

2.

Drugs and behavior:

3.

Drugs and Behavior:

"an"

effect of maturation, sleep,

antipsychotic drugs;

a

rational therapy of abnormal behavior.
4. Convulsions and Behavior: ECT and a “rational"
therapy of depression.

The

For references, I would suggest they read: Grey~Waltor,
Living Brain, N.Y., w. W. Norton, 1953:
Fink:

2;

EEG and Human Psychopharmacology. Ann. REY' Pharmac01.,
241~258, 1969.

Fink:

Cholinergic aspects of convulsive therapy.

142: 475-484, 1966.

If

you wish more
Thank you

MF:kt

citations,

1

will

for the opportunity.

J. Nerv.

be glad to supply them.

‘

Ment. 018.,

�</text>
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                    <text>February 10, 1971

Peter

M.

Levine

2520 Monroe

New

Street, Apt.

C

Orleans, Louisiana 70118

Dear Mr. Levine:
Thank you

for your inquiry about

a summer fellowship.
not have the opportunity to support a
fellowahip this year.

I regret that I

do

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt

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                    <text>February 10, 1971
Mrs. Carol Lewin, President

Metropolitan EEG Society
United Hospital
Boston Post Rd.
Port Chester, New York
Dear Mrs. Lewin:

not have a supply of the EEG classification paper
sufficient to make the many copies you requested available.
I am enclosing some copies in the hape that they can be
duplicated where they are most wanted.

I

do

I would be pleased to be a speaker at one of the monthly
meetings, and suggest you call to set up a date.

I

would also commend my associate, Dr. Jan Volavkc to you,
as a speaker. He has an extensive experience and could discuss
a variety of subjects with much merit (369—7900, Ext. 247).

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF1kt

enc .

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                    <text>'-."='w-1V)‘1¢1Wb"vﬁTtym'mzn

m

vw

sf. -.'-. r». way»

»

,v—n-wu

VVL~Ww-rv-r—vl-~“3I—me a-yrmnn

wt“...ru-qwﬂw

mp...“

“‘Wuwv—lw...—-;. w.¢,..:..at... , “-..._ t ”.7,

vw-zmwmnwwmru-sn

w

'
v

.

y

t
..v

.

.,,

,
W...

.
V

Rwy

.w

February 10 , 1971

7.wa

..._

Dr. Robert Petersen
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

Dear Bob,

I spoke to Dr. Allen Isin of Bulfalo at length today, and
found him knowledgeable about polymers, release rates, hydrogels,
etc. He offered to assist us in determining the release rates of
out antagonists in his polymers.
I

was impressed and we

agreed:

n.

(1)

‘

"Farr-4's

.

some
.
nam‘

He

I would review these with the chemists and send him
cyclazocine and naloxone;
We

their consultant.
in

literature about his processes;

(2)

(3)

'a1-2'1'mwzr

would send us some

Many

a long
My

(out chemists) would call Dr. Kenneth O’Driscoll,

thanks for the

referral. I

acting antagonist.

hope we can get some progress

best.

7w"w:ww:;vtﬁww'mj.~wﬁ'i=u

Sincerely yours,
u'gzvmmm

Fink, M.D.
Professor of Psychiatry

Max
,,,,

V"

A:

MF:kt

cc:

A. M. Freedman, M.D.

.

,,.,..,..

_. t.

m ..

�</text>
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                    <text>wwww‘rr-wx‘

1‘

w,- um.

.z-w-

vvvwm.mw: ‘m‘

.

'

&gt;—

,

Wmv'm~om'-rummwr 7.72:»

--vv

February 9, 1971
Dr. Fritz A. Freyhan
153 West 11th Street
New York, New York 10011
Dear

Fritz,
I

am

most

gratified

in the Council of the
for your confidence.

me

by the support chat you have given

APPA.

I wish to express

my

thanks

I would be honored to join the editorial board of
Compnehanaiue Paychiaxay and shall do my best to support
the traditions of the journal.
My

best regards.
Sincerely yours,
Fink,
Secretary

Max

MF:kt

M.D.

�</text>
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                    <text>Maw-n

»

I

mr'r

‘

.«w

.

w."

xmhwwwrhr'» ‘WWW'IMATWW.’

1,“

~rww"\-&lt; www.msv- —...«—v... -.‘.-.

m.“—

w w.”

..

nun-w, ,-

w-pw—wm— my...” ~

.w...

.
..

.A

February 9, 1971

&lt;

.17..

.
\e
s

V,..,_ﬂw..w...

Dr. David Metcalf

University of Colorado Medical Center
4200 East 9th Avenue
Denver 20, Colorado

.,v,-,W,w-,,.

'5"

Man-m

yaw-re.“

&lt;....

umiyv-mwtrn,

Dear Dave,

In 1965, NIMH supported a collaborative study of schizophrenic
patients treated with placebo, high dose (1600 mg/day) and low dose
(400 mg/day) chlorpromazine for 6 months. In one study, by
H. C. B. Denber at Manhattan State Hospital, EEG records were collected
pre-drug and monthly, from 2 lead pairs (RQ~RT ear, RF-RO). The records
were accorded on magnetic tape and the tapes were analyzed in 1966 in
St. Louis on the IBM 1710 data analysis system. Sample size was 30
seconds; 320 samples per second; without prefiltering; period analysis
for baseline cross and first derivative.
Of 120

.r‘vg’ﬁwmurww

EEG

patients,

The sampling

we

had good records

process

was random,

characteristics before treatment

in

72

subjects.

for there were no differences in
the three treatment groups.

among

,r—a'vmzr

.m—r

m1"

wwrr‘

related changes for each variable using non—
For both lead pairs, dose and drug related
changes were found in an increase in theta activity and a decrease in
frequencies above 40 cps. Variability of frequencies also decreased.
We

-.
.v
Ar

wr-w-ezr-srv—r-r

-

F'rrm.

:*
v.1

emu-m

vmv-nwu'l'ﬂ

.«
w-

«A

«w

vmwxwrwANW-u.‘

statistics.

In an earlier study,

Mme

u

examined the drug

parametric

we

observed a similar

in schizophrenic patients treated with
6

weeks (Fink, 1961).

profile of

EEG

1200 mg chlorpromazine

change

for

These two studies indicate that changes in the EEG after
chlorpromazine are drug specific, dose related in degree of change,
and persist for periods up to 6 months of continuous treatments.

�V“,

_,
.,

Dr. D. Metcalf

—2~

February 9, 1971

,nywwm.

It is clear

similar studies, that the EEG
changes with psychoactive drugs are not "side~effects" or “abnormalities"
but direct effects of the drugs, reflecting the central processes which
from

these,

and many

they are supposed to effect.
We

failed to

make

direct correlations between the

EEG

change and

behavioral improvement with the two doses of chlorpromazine in these
patients, although there was a difference of drug gs; placebo. The
differences between drugs were small,.and while significant in amount,
the behavior changes were small. For a detailed discussion of the
behavior changes, see Prien and Cole (Arch. gen. Psychiat., lg; 482-695,
1968).

.r'v"

xv

uwxmm‘iﬁrww‘WW-swu

”nan-mgr”

"neuter.

If these comments are useful, they may be quoted either as "personal
communication" or as presented at the Society for Biological Psychiatry,
May 1967. Enclosed are abstracts and exhibits of the presentation.

It was a pleasure to discuss these interesting problems. I met
with Turan Itil in Aspen, and told him of your interest in the
schizophrenia study in Copenhagen. He is the principal investigator
and should write to you when he sets up the project.

.1“,

My

,

”nan-r

r7

best regards.
Sincerely yours,

yuan.

rag-w”

'3"
.~

u

Fink, M.D.
Professor of Psychiatry

Max

y.v/;,1-Iv,'-‘.'_‘y.4u

"Wt-w

.m-u-g:

,mrgﬂswl.

Janus-'1

MF:kt

�</text>
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              <elementText elementTextId="47522">
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                    <text>{

lawn."

..

.,w...z-

m a. maxim...” ., ”,“mﬂuy"WW...”W.“magi... \1A'glmWr,

V,

«QM»

1.4g“;

,-'

-

.w’~"‘mWr-x

7..

raw—Mg..- ".7

v.

n ...

ammwwm

1..."--.

..

W.—

....,..r....

V

w.

w,

o‘,

n...

W".—

February 9, 1971
Dr. Edward Gordon

Director-Methadone Treatment Program
Community Mental Health Board

County Office Building
White Plains, New York 10601
Dear Ed,
Thank you

quite complete

clinics.

for the procedural manual for methadone.
and I can understand why it is useful in

It is

establishing

I would be pleased to have you visit our program at Metropolitan
Hospital. Half our patients receive methadone or Kmalpha—acetylmethadol,
and half cyclazocine. The latter group is our more interesting study
_group, for we have the anticipation that this method may allow an orderly
cessation to the addiction, particularly if a long-acting delivery form
could be developed.
Again,

my

thanks for the manual.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>2
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rum—aw

1

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any
e

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-

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:~ ‘V'n‘a'l-

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"as,“

February 9, 1971

A

~..

~

.Iznaryw—vm-v-

mum-,2

Dr. Allen P. Berger
Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Allen,

"nw'mm,

I’vnu-Fyew'VK'

~

WrT-msawmnn-mwnq

Enclosed are four additional "incomplete" records of
patients in the thiothixene~th10ridazine—placebostudy.
Please make whatever copies you wish and return as you
did in the earlier data.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

-r

.

..

H

vw-“v

.:

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~

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,

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�</text>
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                    <text>P1»;- k ~v’.&gt;.-vv

.

.

i
5‘

I1

It

su.

E
F
,

;

February 9, 1971
Dr. Donald Klein

Hillside Hospital
P. O. Box 38

Glen Oaks, New York
Dear Don,

of the APPA
behalf of Milt Greenblatt and the Council
work you did on
we wish to express our gratitude for the fine
annual
meeting.
behalfoof the APPA for our
The arrangements were excellent and I hope that the Association
will renew the contract with the Roosevelt.
On

Hany

thanks.
Sincerely yours,

Secretary
MF:kt

�</text>
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                    <text>~

v» no.» In. n 15990:»J-rw.‘vl&gt;-ﬂ'v’-

1-

w.

13-

«~st

'

‘

w

'1

3" u

_

m... :'1»_‘r\yum.v-w-r--su|:.'~"'&lt;'.r

«mm-”ware an:

“new”

"“

February 9, 1971
Dr. Ronald Fieve

Psychiatric Institute
722 west 168th Street

New

York,

New

York 10032

Dear Ron,
On behalf of Milt Greenblatt and the Council
of the APPA we
wish to express our gratitude for the fine work you did on behalf
of the APPA for our annual meeting.

I believe the publicity was most useful in increasing the
attendance of this year's meeting.
Many

thanks.
Sincerely yours,
Pink,
Secretary

Mex

NF:kt

cc: Dr. Greenblatt

M.D.

.v-vmv-

�</text>
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                    <text>February 9, 1971
Dr. Albert
.—.-.~

,.

ramp

J. Silverman

Professor and Chairman
University Hospital
Neuropsychiatric Institute

Ann Arbor, Michigan 48104

nag-«n

‘v'vn

Dear A1,

l‘ww

I have discussed your letter to Arnie Friedhoff regarding
in the APPA with other members of the Council. The
Assotiation has faced this problem before, and has established
a category of membership; "corresponding member" for this
contingency. Corresponding members are privileged to receive
all communications, attend meetings, participate in committee
functions.

-.

membership

We would be pleased to include you in the membership.
to active status can be made at your request.

Will you reconsider?
«4,

My
awry—mummy”

best regards.
Sincerely yours,

pry,-

.

V

Fink,
Secretary

Max
WNW».

«NW

3!
734'!-

"W"

urJ-‘u-vm—Jr'v

Twmfm.rj-E‘an1-rj.wr

’5».

~

MF:kt

M.D.

Transfer

�</text>
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                    <text>7

February 8, 1971
Mr. E. Marrese

Inmigration Specialist

New

State

York

Employment

Central Immigration Office

68~O9 198th

Corona,

New

Service

Street

York 11368

Dear Mr. Marreae:
Mr. Mark Komloai

will attach electrodes to scalp of subjects;

measure resistance: record brain waves: deliver electronic stimuli;
record responses. He will maintain equipment including, EEG, tape
recorder, oscilloscope and electronic stimuli generator. After each

experiment, he will analyze the data for final analysis.
The

”psychological tests" are electronic stimuli which require

judgements by the subject. The rate and strength of stimulation are
constantly monitored by the psychophysiology technician.

I have no copy of the advertisement in the ﬂow York Times.
appeared September 13, 1970 and was their copy No. 03197, Class 0049,
descriotion ~ Research.

It

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HF:kt

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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="106161">
                    <text>February 8, 1971
Dr. Fred lagan
Upjohn Company
Kalamazoo, Michigan
Dear Bred,
At the APPA meetings this weekend
speak to Ronald Fieve about rubidium.

I

had the opportunity to
has an IND but the
restrictions for human trial are severe. To date he has increased d
dosages gradually to a dose (he could not recall) which seemed
He

insufficient to alter mood or behavior. He does have extensive
laboratory data, primarily blood, urine and EEG measurements.
These have been summarized in a report to the Aachiveb 06 Genenaz
Rbychlattg, but the report has not yet been accepted for publication.
In addition, he has animal toxicology
studies in progress.
He knows

(3 generations of mice)

of Plotman's public statement but diacounts the

evidence as inadequate. One basis for his interest is a review
of 19th centurj literature in which he noted many claims of therapeutic

benefit.

I was impressed with his enthusiasm and interest. He has a
good reputation, and while the evidence for psychoactivity is slim,
I would like to hear him discuss his work in public. If your interest
is sustained, I am sure he would be pleased to discuss his data.

It is

an

interesting problem.
Sincerely yours.
Pink, M.D.
Professor of Psychiatry

Me:

MF:kt

�</text>
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                    <text>u

February 5, 1971
Dr. Ernst Rodin

Lafayette Clinic
Detroit, Michigan
Dear Ernst,

I
in the

am

pleased to propose Dr. Jan Volavka, H.D. for membership
EEG Society.

American

in extensive experience in EEG, beginning in
received his training in Prague, London, Munich and New York;
is the author of 37 publications, 33 in electroencephalography. His
interest is in normative and quantitative EEG, and since 1969 he has
been a principal associate in EEG in my laboratory.
1962.

Dr. Volavka has
He

I believe he would be a valuable, contributing
EEG Society.

American

member

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt
811C 0

of the

v-wv

mm "am-rm,“

w.'ll-—

�</text>
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wwum-m,

“rm-Wm

February 4, 1971
Dr. John R. Hughes
Northwestern University-McGaw Medical Center
The Medicel_School
303 East Chicago Avenue
Chicago, Illinois 60611

"W'

'

;rurgxwwﬁew

Dear John,

:rv

ﬁre-tart»?

«1"

Enclosed are two copies of my review of "Brugs and Cerebral
Function". There is a need for studies of drug effects on brain
function, and while this volume has some interesting reports, the

overall effect is limited.

I
Nth—5.3

ammunzw,

made me

Thank you

read

it

for the Opportunity to revtew this volume carefully than I might have otherwise.

more

it

Sincerely yours,

_

,

award“

“"1."

vzsr'ww

Fink, “.0.
Professor of Psychiatry

Max

W

‘Y'ur'r

“Th7!"

Mszt

Wmmﬁmtrmrw

‘1

r;

, Au.“ - “Ai‘,i___..._‘.‘m.

,7

,9;

c

,

:M»~

-

:4,

1,;

mums“,

navrvm

m—

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Dr. Richard Brotman
York Medical Coilege
York, New York 10029

New
New

Dear Dick,
As I discussed with your secretary, I have made arranggments
Dr. Stephen Bernstein and a committee from NIMH to use Room 64
on February 18, between 9am and 1 pm.

for

I

trust this is satisfactory.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

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Dr. John R. Hughes
Northwestern University-McGaw Medical Center
The Medical School
303 East Chicago Avenue
Chicago, Illinois 60611
Dear John,

Enclosed are two copies of my review of "Drugs and Cerebral
Function". There is a need for studies of drug effects on brain
function, and while this volume has some interesting reports, the

overall effect is limited.
made me

Thank you

read

it

for the opportunity to review this volume more carefully than I might have otherwise.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

it

�</text>
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                    <text>mus-s 43:.

,

‘

r.‘

,

.

wzw

&gt;
.

-

."rurvy

w- L'n’(r-‘H"r-Y'IAr—n .9.an

.

v

raw»

7",“;

-

=

mn'T-‘J

DVWT'1T)«‘R-(".‘

—-.

~wu~

N.‘

wuwwr-w—v

WIMI'EW'

.

_

1am.“

mun-war

mun

February 4, 1971

V,

"Iv-“.“mev-u—mm-IW'"!

2

f,
.k.

“Ya—rm",

Dr. Michael A. Taylor
9309 Murillo Avenue
Oakland, California 94605
Dear Mickey,

thanks for your warm and enthusiastic letter.
receive your acknowledgement.
to
delighted
Many

I was

g"

my

As

~w

W—

'rv'

my

air.

.-

"WWW

‘1'

plan

some

details

for the projects, it would be most helpful if you would
projects now, if you wish, so that some administrative

can be completed. Any notes you may wish to send can be
discussed here, and we can help you write the necessary protocols.
I have discussed some suggestions with Dick and he may be of some
help.
I look forward

to seeing

you in

July.

Sincerely yours,
Max

Fink, $4.0.

Professor of Psychiatry

MF:kpt

ﬁrm-"-

rum-Wu

.

-.

u--—

.rvnww-w'"w-'a~r&lt;zuw‘

�</text>
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~

'rnmwl'wme-vmamn-m-v\‘Jm'ﬁrwﬂﬁVFW

m

t

f

.

'

V

mm-

.:.,_,.,...vv.."...

mm

3“

‘Nr‘

February 4, 1971
Dr. Daniel X. Freedman

University of Chtcago
Department of Psychiatry
950 E. 59th Street
Chicago, Illinois 60637

Dear Dan,
Some months ago I submitted our report, "Unilateral and
ECT; Effects on Memory, Depression and EEG” for your

Bilateral

consideration for the Archives.
May I
My

(Your manuscript 0658.)

ask for a status report on your review?

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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«:7

max. umrww:

.

W”:

February 4, 1971
Dr. Barbara Sonowski
Hoffman LaRocne

Nutley,

New

Jersey

Dear Barbara,
Dr. Itil and I have reviewed the notes for the CDT exhibit,
and have made a few corrections. Please note the addition to
Table IV, correction in Table V, and deletion on page 9.

have reviewed our

EEG data and would like to add the
which
have
we
yinformation
not published previously, but which was
analyzed at the time of the original studies. Please add page 9A
to the presentation, and to any texts of the report.
We

Thank you

for your fine editing.
Sincerely yours,
Fink, m3.
Professor of Psychiatry

Max

MF:kt
611C .

mm Muwm'lwrnww‘

�</text>
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                    <text>.u'rvn awe—wk

February 2, 1971
Dr. Marion J. Finkel
Deputy Director

Bureau of Drugs
war-3w:-

Food and Drug Administration
Rockville, Maryland 20852
Dear Dr. Finkel:

letter of

January 25, is encouraging. As a
of
new drugs with industrial support
participant in the evaluation
and in attempting studies of drugs of limited commercial interest
(notably the narcotic antagonists cyclazocine and naloxone), I
would support your suggested use of seminars. There may provide
the opportunity for researchers and administrators to reconcile
differences in their opinions on the requirements for studies in
Your thoughtful

man.

I

would be

willing to participate as a speaker or panellist.

"criteria” of animal toxicology which must be satisfied
before drugs are taken to man is an issue that has provided much
travail in studying new drugs. Specifically, I have been repeatedly
The

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advised that certain trials in man were not ”proper” or "legal”
without extensive animal trials in 2 (or 3) species for 3 (or 6 or 12)
months with_a variety of pathological studies. An irony of these
"recommendations” (or ”guidelines”) is he experience that teratogenicity
and toxicity are determined as much by differences among species and
among individuals as by dose, duration, and route of compound
administration. A slavish recourse to a presumed minimum animal
toxicology profile has made much research too expensive, especially
where compounds do not have an immediate potential for financial
success.

issue that haa’been of personal interest is the improvement
of methods for the assay of psychoactive drugs in volunteers by the
use of physiologic indicea, particularly measures of the CNS like
the quantitative EEG. But this issue may be too technical for general
discussion.
An

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February 2, 1971

Such meetings should be encouraged, to allow additional
intercourse between administrators and reeearchers, to allay the
suspicions that have arisen aince the guidelines were first proposed.
Thank you for your invitation, and I do believe that such public
seminars will be papular and well subscribed, reflecting an important
concern of researchers, industry and government.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>7

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February 2, 1971

,l
-

t
,

Dr. Peter Crown
Modische Faculteit Rotterdam
m.

:9
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a.

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Thorax Center
medical Faculty
Rotterdam, The Netherlands
Dear Dr. Crown:

associates and I have had the opportunity to review your
application, and I am pleased to offer you an appointment in the
Division of Biological Psychiatry, effective this spring. The
exact date will depend on your time schedule.
My

At present salary levels, I believe I can negotiate an
annual stipend of $12,000, such perquisites as are customary, and
a position of research associate. To make this appointment effective,
I will need to know your anticipated date to start.

I

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planning

are indefinite.

As

visit to EurOpe in late March, but the dates
soon as the dates are formalized, I will write.

my

I look forward to meeting you,

w

-

am

in our programs will

and trust
be mutually rewarding.

that your participation

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

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�</text>
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                    <text>February 2, 1971
Dr. Edgar Gruuwaldt
Geigy Pharmaceuticals
Ardeley, New York
Dear Ed,

1‘W'rrrl'v

ma¢n§ﬂp~

W

W.

_

Enclosed are the interim reports of our EEG pilot study
of GPA 1714 in volunteers. we have defined a dosage
is
safe and which alters the EEG of our volunteers. The that
preliminary
data is that of a centrally active compound with an EEG profile
usually associated with relaxation and euphoria.

I have made the necessary inquiries about the
l—Dopa on EEG and have just received the citations
compare the

effects of

GP

41299 to £~Dopa.

effects of

necessary to

I trust these data are useful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mrzkt

�</text>
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yebruary 2, 1971
Dr. William Guy
George Washington University

Biometric Laboratory
1145 Nineteenth Street, N.W..

Washington,
Dear

D. C .

20037

Room 618

Bill,

Enclosed is the disposition report of our study
Biometric Laboratory and 3 new RPR forms.

Sincerely yours,
\Wl'rl‘"1|"-'?'

.mxr-mvnr

Fink, H.D.
Professor of Psychiatry

Max

u

.y

&lt;-r.,-cu

"WV:

MF:kt
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list

at

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February 2, 1971

....

f."'.‘/v&gt;.\"l

van-«u

awn-army:

4
v

Dr. Thomas Williams

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Tom,

Enclosed is our application for continuation of support
of MH~15561~03. I would appreciate your steering it through
the appropriate processing.
Many

thanks.
Sincerely~youra,
Max

Fink, H.D.

Professor of Psychiatry

Mszt
em: a

yuan...»

.Lgﬂ‘Vr

)_r

:
-

«v.

amnmwrgmv

‘

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m—mmwwa-n-cwzmwxnmmvrm-m ma w:
&gt;~;wv¢:-wr1thnz~&lt; : "1“”"“"\'.'I"WW"~‘¥NGW'Y'VWWAWC

-

—

4-

way

n“w---x1'v:

w-w

.

.-._-

-

mm

avmvmw -.-

,

um‘u—‘Wr-‘A

-—.

..
'.-

.x-

—

February 1, 1971

-"w-WWTW’”"’WWWWWF"K1'IWW’W—w

Dr.

J.

Mbndels

Associate Professor of Psychiatry
Department of Psychiatry
c/o V.A. Hospital
University and Woodland Aves.
Philadelphia, Pennsylvania 191I4
Dear Joe,

Earlier this month I submitted two copies of a contribution
One of my associates has reviewed
to EEG and Clinical Psychiatry.
the text and found a number of small errors. I have corrected
these and to avoid the expenditures of corrections in galley, please
replace the two copies in your hands with the two enclosed.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
awn”

«.

'32-

n

Mszt
enc. (2)

~~

�</text>
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                    <text>February 1, 1971
Dr.

Fritz Freyhan

New

York,

St. Vincent's Hospital
153 West 11th Street

York 10011

Fritz,

Dear

as I

New

I

was honored by the Association's election as Secretary,
by the renomination. It was specially kind of you to

am

describe my service as secretary as particularly useful to the
Association, for I have tried to exercise the responsibilities
of the position to the continued growth of the organization.

If the services have been of such merit, perhaps three years
is sufficiently long to judge whether stewardship should be
extended. It is unclear to me why the Association insists on
longevity in

some

positions

and not in

others. Nevertheless, I

have found the position of Secretary regarding and interesting,
but no longer challenging. While I would be honored to continue
to serve the Association, I would not appreciate another term as

secretary.
Among

the complaints of the

was the lack of opportunity

members

regarding the association

for participation.

belief that the Association should involve

It

more of

has been

its

my

members

in the program and the Program Committee; in the council; and in
the publications. So far I have been successful only in encouraging
additional participation in the committees of the Council. Perhaps,
encouraging a transfer in the office of secretary after a few years
will provide a model for other positions in the Association.
Again,

my

thanks for your kind words and recommendations.

Sincerely yours,
Fink,
Secretary

Max

HF:kt

M.D.

�</text>
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                    <text>.

vm

, rna-zvua-A-vr'w—s -»

“mp-n

,

”Hutu—,—

waswrvmgvm

.ylw—mrngw-ppam

l-wiwwa‘x"

2w 'a-u'm' uwvvm

"(c-”u;

.

u.

an.“

‘

?:.'v":‘tw".t.r».‘|vJv-Hr...

February 1, 1971
Dr. Jerome Levine
Psychopharnacology Research Branch
National Institute of Hontal Health
5554 Wisconsin
Chevy Chase, Maryland 20015
Dear Dr. Lavina:

RE:

NR-l3358-04

are writing to request an extension of the budget poriod
for 9 months, to 12/31/71, without additional funds.
With our prosent balances, this will permit continuod support of
the principal personnel for an additional two months (to 5/31/71);
and the services necessary to completo the write~up and final
rogorts for the romainder of the budget period (to 12/31/71).
of

we

MH~13358~04

In the event our renewal request

starting data

program.

be made 6/1/71,

is funded.

we

request the

to allow continuity of the ongoing

Sincerely yours,
Fink, M.D.
Professor of Ysychiatry
Max

Principal Investigator

Alfred M. Frocdman, M.D.
Choiraan, Dopartuont of Psychiatry

Mtg. Lorraine Looker
Director, Roaoorch Administration
MP:kt

,‘

-.

�</text>
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                  <elementText elementTextId="103429">
                    <text>April 2, 1971
National Library of Medicine
Bethesda,

Maryland

Gentlemen:

I an anxious to obtain a

copy of the following volune which

is not available at the ﬂow York Academy of Medicine or the major
medical achool libraries in the city:
Monographicn Ans Den Gesamtgebiotc der Neurologie
und Psychiatric. Vol. 68, 1939. Stringaris,

It is

an essayy on hashish.

If this in available at the Library I will

request through the

New

make a formal

York Academy of Medicine.

Thank you very much

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

M.

�</text>
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                  <elementText elementTextId="106170">
                    <text>Murch 31, 1971

Dr. Michael A. Taylor
9309

murillo

Oakland, California
Dear Mickey,

it

The application is good, as
some additions.

for

far as

it

goes.

I

am

returning

Please review Pitts and McClure theory of chemistry of
lactate. ‘Thcre were some letters that were published
anxiety,
in response to our letter, that questioned the significance of a
lactate test, assigning a peripheral value to the symptoms. This
data should be referred to, and critiqued. Can you devise a test
of these criticiams?
(1)

and of

(2) You may wish to call Dr. Pitts in St. Louis (314 F0 lu4730):
and ask
tell him what you propose to do; ask him to he a consultant:
if there is any additional published, or unpublished data or hypotheses
he can make available to you.
i

If the separation of populations is successful, how can this
test be used in subsequent studies? In assessing treatment infailures,
depression,
for example? Does this test have any relevance to anxiety
(3)

or in schizophrenia?
human

(4)

What

are present tests for antianxiety—agents (animal screening,
Are there any limitations to present designs?

clinical)?

(5) I will ask Dick to describe equipment and facilities. You
should check budget, co~workers, comolcte biographical sketch, research

objectives.
(6)

Make up a

permit form to be signed by patients.

Separately, I will ask Dick and Voita Volavka to send you their
comments. Filing date is June 1.
Kirby is bloaaomigg nicely. Dick started this week. The resident
rotation is assured for July 1, for 4 NYMC residents at least, for 4 mos.
each. He will have to provide our own supervision. Staff seems adequate
in M.D.'s, S.W., psychologists and aides - short in nurses.
Have fun!
Max

HF:kt

�</text>
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t
k

g

E

E

March 29, 1971

Capt. Robert Levine
228 Texas Drive

Dyess AFB, Texas 79607
Dear Bob,

Stan has gone over yhe data you sent him, and his asked
me to forward the analysis - which is enclosed. He suggests
that the rigorous approach views the data as 3 sets of repeated
measures. Because of the small sample size (most probably) neither
the analysis of variance F nor the means and 5.0 are significant.
If the sample size can be increased, the test should be re*run.
Both he and I made some notations on the interview score
The suggestions are based on the lack of clarity of

sheet.

the item divisions or definitions.
‘Our

best regards.
Sincerely yours,
.1... Fink, 2.4.3.

Professor of Psychiatry

Hszt

�</text>
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                    <text>March 29, 1971
Dr. Julius Korein
Dept. of Neurology
H. Y. U. School of Medicine
550

New

First

York,

Dear

Avenue

How

York

Julie,
I

copy of your recent report, "The Effects
Behavior and Electrolytes”, in the g¢§,m.n.;
and any other reports of your lithium/EEG studies.
would

of Lithium on

appreciate a
EEG,

I am sorry we did not meet at the Metropolitan EEG. Your
technician asked many questions, reflecting an enthuaiastic

interest and an intimate experience with the problems of EEG
and drugs. Give her my best regards, and my thanks for making
the evening a challenging experience.
Thanks

for the reprint.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

�</text>
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                  <elementText elementTextId="103430">
                    <text>,,, may, :- wﬂ

Vl:y:'\:'

”W ~

4".“ wt.vt.~..,i-r

,-

"1.:

.~;~,,.,.“.--x—qim-wpawn:,.--_,...‘,,..,fwrw,m-mi.
A

.~

...

1,

..

..

0.

I‘:ul'.jr'rvvv&gt;~r

-wx—

~

swan."

4*:h'rwv'11

N.

~w

.

i-“

wwv nw

-——-—vr~mvn---v.

an

.
mum.

v.

acm.

“1"

March 29, 1971

J. Kuhn
C. H. Boehringer Sohn

Dr. Franz

Ingelheim an Rhein
west Germany
Dear Dr. Kuhn:

we look forward to your visit in New York this spring.
Dr. Terry will make the necessary arrangements for your stay,
and I am writing to raise a few questions so that we can
provide the facilities most useful to your visit, and establish
a relationship which may be most useful.

In our laboratories, we are now carrying out EEG classification
studies of new drugs in volunteero; assays of marijuana, both
acute and chronic; and reviewing data from earlier studies of
marijuana, ECT, methadone, 233. You may wish to observe our

recording and analytic work; to participate in or undertake an
on~going study; and/or analyze the data of one of the projects.
You

also

may

wish to familiarise yourself with the analytic

- the computer analyses, statistical processing and drug
classification, either of an ongoing study, or a completed one.

programs

If

actual

of

EEG

you wish, we can also arrange for someone to review your
program needs, assuming you wished to do some processing

data in your laboratories.

With these facilities in mind, would you provide us with the
questions which you wish answered; or the goals of your visit. An
I correct to assume that you are interested in establishing a

collaborative or a consulting relationship, both for studies in
animals and man, toward identifying and developing new psychoactive
drugs?

If these questions are

indeed the focus of your

visit, it

would

be helpful if
descriptions of the principal
items of equipment now in your laboratories, particularly the EEG
you would send us or bring

w-w

5

�,

-.

raw-.1.- vanes-V:-(w

xvamv...‘ .nwuvgw,. w 5‘

y—v 300a"?

“m

-2-

Dr. Kuhn

Hnrch 29, E971

tape recorders
year, capacity for tape recording),
model, peripherals,
(make,
and
computers
model, speeds, tape size),

amplifiers
(make,

.-va~

size of

(mnkc,

memory).

Again,

I look forward to your visit,

productive relationship.

and to developing a

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
cc: Dr. E.

N. Terry

�</text>
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I

.W

wrw

Hutch 29, 1971

”:8.

E. no stone
591 Horton St.

Boston, Massdchusottn 02126
Dear Mrs. Stone,
For the forthcoming issue of the Seminar. on BOT, I would
like to instruct tho authors as to the proper style for citation:
for the journal. If regular fact enacts are avnilable, I would
appreciate 9 copios.
Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>wmanw—w-‘uu

aymmnm ..,

m

,.

,,

nmx
_

=mmw.-u

.-

March 29, 1971

Dr. Julius Korein
Dept. of neurology
I. Y. U. School of Medicine
550

New

First

York,

Dear

Avenue
York

New

Julie,
appreciate a

copy of your recent report, "The Effects
Behavior and Electrolytes", in the J.N.M.D.;
and any other reports of your lithium/EEG studies.
1

would

of Lithiun on

EEG,

I an sorry we did not neat at the Metropolitan EEG. Your
technician asked many questions, reflecting an enthusiastic

interest and an intimate experience with the problems of EEG
and drugs. Give her ny best regards, and my thanks for making
the evening a challenging experience.
Thanks

for the reprint.
Sincerely yours,
Me: Pink, M.D.

Professor of Psychiatry

Hrzkt

ran—W

�</text>
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                    <text>u,

M"

Wm

Hatch 29, 1971
Dr. Fred Regan
Manager, CNS Research
Upjohn Company
Kalamazoo, Michigan 49001
Dear Fred,

Since our last note, we have established a dosage for diazepam,
and begun our defined classification study of U 28,773. It should take
8 weeks for the data collection, and 2-3 for the analyses, so that I
anticipate our report by mideune.

L'ﬂm.

:.

Your notes on the duration of

action of U 23,773 are most
with
for
clear
so
duration
a
interesting,
effect, we may wish to
approach the clinical effects in a study of a different design.

A

with a flat extended duration of action would be most
powerful as an antianxiety agent. Our present problems with diaropam
and chlordiazepoxide are their relative short duration of action,
requiring repeated dosage, repeated risk of sedation, and the
development of tolerance, requiring more frequent administrations
in some patients. An effective, flat dosage regimen may avoid
some of these difficulties. Your note, that a halfwlife &gt; 24
hours would make you "bearish" is puzzling. Such a feature may
increase the risks of uncontrolled use, but may be more useful
in reducing the euphorigenic risks. The higher tithe, higher
euphorigenic action, and higher addiction liability of heroin
compared to methadone are documented. Both drugs effectively
compound

reduce opiate hunger, opiate withdrawal symptoms, and may usefully
substitute, one for the other. Yet, methadone is considered the
safer drug, with its longer duration of action. The extended duration

of action enables

some

useful applications.

Come visit New York soon. Meanwhile, even if the rubidium fever
has cooled, the enclosed announcement may be of interest to someone
on your staff.
try to be there and will send you a summary if
nouone else is able to go.

I'll

See you soon.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

�</text>
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                    <text>March 29, 1971
Dr. Sherman Kupfer

Associate Dean
Sinai School of Medicine
Fifth Avenue and 100th St.

Mount
New

York, New York 10029

Dear Dr. Knpfer:
We have been asked by members of the Ecunt Sinai School of
Medicine to make available samples of blood from patients receiving
heroin in the course of their treatment for opiate dependence.
We would like to cooperate with reputable scientists who may
contribute to our understanding of the opiate dependence problem.

I would like to assure you that the study has been endorsed
the Research Committee of the New York Medical College, that
it is undertaken in the facilities of the Department of Psychiatry
either at the Metronolitan Hospital Medical Center or in our
laboratories at 5 East 102nd Street: and that all precautions
which we deem necessarv for the protection of our nationts have
and will in the future, continue to he talcen. The amount of
heroin varies depending upon the need of the subject and design
of the exocriment. The amount varies from 5 to 75 mg i.v., usually
given in ch of Saline within 1 minute.
by

At the time that Drs. Puezkin, Aledort and Cutfreund visited
I approached the problem sympathetically, and accepted their
credentials and sincerity, and assumed that their request was a
simple one. In View of the complexity of the questions, perhaps
we should ask the assurances of the appropriate authorities at
me,

that: the protocol has been approved by the
of the Mount Sinai School of Medicine; and
committee
appropriate
that any proposals sent to any third party in which we are named
or referred to, receive the prior approval of our Department of
Psychiatry Chairman, the Research Committee and Dean of our school.

your school

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>Hutch 29, 1971
Mrs. E. M. Stone
591 Morton St.

Boston, Massachusetts 02124
Dear Mrs. Stone,
For the forthcoming issue of the Seminars on BUT, I would
like to instruct the authors as to the proper style for citation:

for the journal. If regular fact sheets are available, I
appreciate 9 capies.
Thank you.

Sincerely yOurs,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkt

would

�</text>
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                    <text>‘swew—

um‘wimwmvr‘ﬂm

wryﬂv...”

_,,_.V

AWN,

_

Twﬂw

,

March 29, 1971
Dr. Sherman

anfer

Associate Dean
Sinai School of medicine
Fifth Avenue and 100th St.

New

York,

New

$6?)
4

1:0

Mount

\

York 10029

Dear Dr. Kupfer:

f9

have been asked by members of the Mbunt Sinai School of
Medicine to make available samples of blood from patients receiving
heroin in the course of their treatment or opiate dependence.
We

would like to cooperate with reputahle scientists who may
contribute to our understanding of the opiate dependence problem.
If
I would like to assure you thht the study has been endorsed
by the Research Committee of the ¥“New York Medical College, that

We

it is undertaken in the facilities of the Department of Psychiatry
either at the metropolitan hospital Medical Center or in our

laboratories at 5 East lOanJMStreet and that all precautions
whichm deem necessary for the protection of our patients have
and will in the future, cohtinue to be taken. The amount of
heroin varies depending upon the need of the subject and design
of the experiment. The amount varies from 5 to 75 mg i.v., usually
given in 2cc of Saline within 1 minute.
At the tine that Dre. Pusskin, Aledort and Gutfreund visited
me, I approached the problem sympathetically, and accepted their
credentials and sincerity, and assumed that their request was a
simple one. In View of the conplexity of the questions, perhaps

we should ask/the

assurances of the appropriate authorities at

your school that: the protocol has been approved by the
appropriate committee of the Mount Sinai School of Medicine; and
that any proposals sent to any third party in which we are named
or referred to, receive the prior approval of our Department of
Psychiatry Chairman, the Research Committee and Dean of our school.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max
‘

,

—Tu

ups-In":- qwn’ " “ “any“.

Mszt

k

�</text>
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                    <text>twctmv

»

q..«...w.—

4.

'&lt;Iy'w'—-

‘
v
..

a...“

March 26-, 1971
Dr. Jerome Levine

National Institute of Mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear

Jerry,

are pleased to enclose a copy of “Computer Aided Interactive
Psychiatric Diagnosis Programs". The volume contains the logic and
programs in PL~1 (DOS) which are Operational on an IBﬁ 360/40 and
uses the CDC display terminal with digiscribe attachment.
We

There are two diagnostic programs, the BPRS of Overall and
Gotham, and the Diagno~11 of Spitzer and Endicott.
would be pleased to demonstrate these programs, and
the report may be useful.
We

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬁrzkt

trust

“a

�</text>
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                    <text>haw ..,._.....w TE“... .7, he}.

_

W , m1.

.

...-

.

..

"arms-u .twv

we“

guru-rm

.Wz-Wramw qua Na: wu-r- ."r—Fryr-IIWUI':E¥L

,

-

-_—w

,-

"’\'&gt;'r—n

.; Kw

-

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)1: u

u

--

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newmwxm”.

"WWFN‘M‘-

v
i
WW“

TI'D‘CI-I'

.
VJ.-.

Wnimrﬂm

March 25, 1971
Maw

amnmwn-uw

.

nun

Capt. Robert Levine
228 Texas Drive

Dyess AFB, Texas 79607
Dear Bob,

w&lt;vsw.u~;mm.w~r1

to receive your letter and find that you are so
active. There is a great need for data on the incidence of drug
use, and a sample of 5000 is a good one, although it can be criticized
as too large for the purposes of the study. Ybur solution, to check
every 10th booklet, is probably a good one not only for your reason
of practicality, but the redundancy that will probably result from
such a large sample in a basically homogeneous population (i.e.,
male, AF, 20-30, education above 8th or 10th grade, etc.).

It

1w

-

rm

was good

—

suggestions about the questionnaire. The use of
cut-offs at 18—29, 29:25, g§730, ... provides confusion and
ambiguity. Perhaps it could be clarified. (The study may be of
sufficient interest to NIMH for you to get a small grant for
keypunching and data processing.)
I have

it
1...

...

~.A..K.-m,,..vl

u

w-—IW1'FJ:-——.-.\u~vu-n

qmm

u

m!l-&gt;-'V5)F'"V’.Irv1hlulw-nrw

r
-—-

.&lt;
-

r»

’WJKa-v‘rl'"

some

The data on the Zung

to Stanley.

scale looks satisfactory,

and I

will give

Since last writing, I have assumed responsibility for 2 floors
we have begun some
at Kirby Manhattan Psychiatric Hospital, andNYMC
residents in
supervisions of the staff. There will be 4
4 month rotations beginning July 1, in addition to the Kirby staff.
This provides a nucleus for patient care. We even have some funds
for supervision and consultation, and this is reasonable as a

beginning.

The Methadonization of NYC is increasing rapidly and even
G.P.'s are in the act. Soon, methadone will be recommended for
everyone and the two logical cheap resolutions will be touted:
free methadone from selected local M.D.'s then from alcohol

distribution centers (bars). But, our studies of the antagonists
continue, although we are more actively studying marijuana.

"wn'nu \J"!

a:

.

.._,,

�v»

r

-r:: —\ «a»

2x197-.. Wu”

A

~‘*.W!",v~‘u

&gt;

V

~rv

~u-

m

mjr’sr'U'av-«W

-.-~v-~mm,-vﬂ-‘~-":W' ’WAWM'HJ‘L:qv

Dr. Levine

,

,

,-

~2-

—

'lin-Afn'."w"cram «my

ruﬁre-Tn-m’"

-

..

r :-- w

March 25, 1971

Dick's studies are progressing well. We have established a
consulting relationship with a chemist for his spinal fluids. Mickey
has sent me a protocol for the continuation of the studies of lactate.
any studies you wish to undertake at Kirby? As I
wrote to Mickey, it may be helpful to do some protocol writing now
and suve time later.
Are

there

pass your letter on to Stanley and Dick, and hOpe they
I'll
answer you soon. Will I see you in Weshingtoa in May at the APA

and 38??
Hy

best regards,

and keep up the good work.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.
~..-

-~—u:-—.y

..-

.

Mszpt

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                    <text>mw-amvxs-g...r—. .

March 25, 1971
Dr. Ali Keskiner

Institute of Psychiatry

Missouri

5400 Arsenal

Street

St. Louis, Missouri 63139

Dear

Ali,

Apparently, the trip to California was successful. I have
requested the reimbursement of your expenses and you should receive
these within the next few weeks.
we

For those physicians who have requested additional information,
had planned to send them copies of the two CDT reports:
Holden, J. M.C., Itil, T. M., Keskiner, A. and
Fink, M. Thioridazine and chlordiszepoxide, alone
and combined,

schizophrenia.

Itil,

in the treatment of chronic
Comp. Psychiat., 2; 633-643,

T., Holden, J.

M.

C., Fink,

M.

ﬂhapiro,

1968.
D. M.

and Keskiner, A. Treatment of chronic psychotic
patients with combined medications. Proceedings of
the Vth International Congress of the C.I.N.P.,
Washington, March 1966.

reprints here, since the bulk was kept by
it be possible to send a copy of each reprint
to each of the physicians who signed for them? (Also, would you

We do not have the
Mike and Turan. Would

please send

me

a few copies of each

article?)

Before Turan left, he indicated that he might be back in time
for the APA and, if so, he would participate in the exhibit. I
would like to call you a week or so before the meetings and perhaps
you and I, with or without Tursn, can arrange to cover the APA exhibit.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MF:kt

i

\

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                    <text>March 24, 1971

Stefania
Eginition University Hospital

Dr.

D.

Vassilissis Sophias
Athens, Greece

74

Dear Costas,

Enclosed are capiea of a

letter to

Dr. Miran sent today.

I ask you discuss our original suggestions of January 4
and advise us as to its feasibility, your criticisms and
him
with
any alternate suggestions.
May

My

best wishes .
Sincerely yours,
Fink, M.D.
Executive Director
Max

MP

:kt

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                    <text>hi I»

March 24, 1971

Br. C.

J.

Mirna

University of Athens School of Medicine
Department of Biological Chemistry
Goudi, Athens, (609) , Greece
Dear Castes,

It

was good to receive your

letter

and

I immediately reviewed

the reporte in my files.
summary is enclosed. Unfortunately,
the data in, so far, insufficient for some reasons given in the
summary. Our own studies are in progress, and the preliminary
data which Br. Volavka will present in May is also incomplete.
A

You may use

this

improved within a

summary, dated as

year.

it is.

Hopefully

it will

be

to our study, I am confused. When we discussed the program
in Athens, we believed the focus to be a population evaluation
followed by a detailed examination, including laboratory tests in
a selected sub-group. A proposed outline was sent to Dr. Stefania
in early January, elicited an ambiguous reply, indicating that
changes in the law made the study impossible.
As

enclosing a capy of that proposal and timetable. I would
ask you to discuss this fully with Dr. Stefania and tell us if the
study is feasible, and whether our suggestions are useful and
practical. If not, would you propose another work-schedule, and
advise us if the legal problems can be solved?
I

am

Good

luck

on your volume.

Sincerely yours,
Max

Fink,

M.D.

Executive Director

HF:kt
enc.

cc: Dr. Stefania

"1"10‘

,r ...,,.

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                    <text>Wm

'I'J-I-cm

mwr

Mhrch 22, 1971
wwrnwrmw-wvvq—wv

Dr. Barrett Scoville
Deputy Director

»~'

~'

"a,”

Division of Neuropharmacologicel

1

W

N

W

nu.

n
&lt;.

,nm

Drug Products

Office of Scientific Evaluation
Bureau of Drugs
Rockville, Maryland 20852

”VP”

Dear Dr.
nag—.7-

v'vw'"

,7

:r-

«war-rmraww—x-y-gwmwg

.-.V

:uvmmvmew"

-.—v-

-n—m

www-

Scoville:

RE:

IND

6825

Methadone is obtained from the pharmacy at Metropolitan Hospital,
York City in liquid form. The appropriate dosage is measured by
trained (R.N.) nurses and dispensed to patients diluted with grenadine
syrup. Each day's dosage is dispensed separately; patients coming to
the clinic 5x, 4x, 3x, 2x a week.

New

For £*a~acetylmethadol, we have received pure powder foam Merck,
Sharpe and Dohme Research Laboratories, West Point. Pennsylvania 19486.
This is measured cut by the licensed pharmacist at Metropolitan Hospital;
dissolved in grenadine syrup; and dispensed 3x/week. Dispeneation by the
same

trained

R.N. personnel of the methadone

unit.

Sincerely yours,

.

Fink, NJ).
Professor of Psychiatry

Max

�</text>
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                    <text>r- vlmw~zu~.u-u. .

‘14

npv

-r

5

w~,~m'-

wyrlﬁi‘

"tum-2w

mmwnw’:

A.“ ,

March 22, 1971

Dr. H.

M.

van

Prug

Psychiatric University Clinic

Division of Biological Psychiatry
Dostersingel 59
Groningen, Rolland

Dear Dr. Van Prong:
For my presentation at the ISBP symposium on September 30,
I will present a report describing our EEG studies of heroin,
cyclazocine, naloxone and methadone; and our clinical experiences
with narcotic antagonists. A title may be:

Clinical

and

and

EEG

Studies of Opiates

narcotic Antagonists

I shall also be prepared to present our EEG and memory data
with cannabis, in discussion of the reports of others.
Although I had planned to be in Europe in Hatch, the
been postponsd.

I look forward to the meeting.
Sincerely yours,
Max

Fink, ﬂ.D.

Professor of Psychiatry

Mszt

trip has

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                    <text>March 22, 1971

Dr. Barbara Sonowski
Hoffman ~ LaRoche

Nutley,

New

Jersey

Dear Barbara,

at

Don Shapiro and Ali Keskiner manned the CDT exhibit
Anaheim ~ Dr. Shapiro on Saturday, Sunday and Monday (March

Drs.

13-15),

and Dr. Keskiner on Tuesday (March 16). The exhibitoarea was not
open on Neonesday, although the meeting officially continued to that

day.

Both men said that the eihibit was legible and presented the
data clearly and well. The questions were largely of a superficial
quality, perhaps a reflection that the attendees were physicians of
diverse background, only a few with experience or interest in

clinical psychiatry.

Also, the exhibit

was

part of the commercial exhibit section

and may have been viewed with some caution by the
The

has a

It

visitors.

description of the exhibit

list

of about

20

physicians

was well done, and Dr. Keekiner
who asked for additional information.

Their principal suggestion has to do with the exhibit's location.
at a "dead~end", and as such, both felt the exposure was limited.

was

Their expense vouchers are enclosed, and I understand they will

be reimbursed by Hoffman LaRoche.

our
end

interesting and I believe useful for
exhibit. I will arrange “coverage" for that exhibit at the
of April.
The experience was most

APA

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HF:kt

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                    <text>awn-v

r—ﬂ'www‘vﬂw’u‘-

:- w~

up“

",—

Ww-W'...

wrww‘

mvv‘n'rnmmw-nw-WICI'rWI—v

”mv

W'v-nnnwrwrm-"j

r."

w,

mv‘w‘

March 22, 1971
Dr. Burtrum Schiclc
‘w-v

77 Barton Avenue

ﬁinneapolis, Minnesota

-'r--;w-r1~r

'-

“.mrlum‘d

-

Dear Burt,
A few months ago I completed the enclosed technical report
on the present state of the EEG program for psychopharmacology.
My

mvpvvm-

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

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                    <text>.ﬂ

mun-x

~va

~

'

-v','l""r"l'

W

‘

Wan‘t‘an-mrvgﬁwwrmm‘m nvA-n-rlwwmmman-.3

WNW—WW
_

-m&amp;':m‘nwl~-IV-mo?m“¢“'9‘

-----

W'.‘W&gt;'~-~

"'e-r-E-I-v1a-rusu

»r£'n'-‘Mn-.1rtr/!"~Y‘

-,"~—"#'ﬂ“r

March 22, 1971

Dr.

J.

Mandela

c/o V.A. Hoopital
University and Woodland Aves.
Philadelphia, Pennsylvania 19104

Joe,

Dear

Enclosed is a revised chapter, "The Electroencephalogram in
Clinical Psychiatry”. Your comments were cogent, and I trust I
made the changes in a useful fashion.
but

(3)

Table I has been revised.

this simplified version

It

has been published elsewhere,

can be published.

"0-.-

‘
“a.

w
&lt;
..

7-».

VMI'WFW

r,"

a'—,

"W

(11) The controversial sections on pages 9 and 10 are deleted.
There are useful for the specialist, but may have no place in a

textbook.

(14) Unfortunately, there is no good data on the
ﬁrDopa or PCPA on the EEG, and these must be obtained.

effects of

mlwmbé"

Thanks again

«r

for the excellent editing.
Sincerely yours,

WIMWVYH'mwmarAme'

Fink, M.D.
Professor of Psychiatry
Max

1n

'm'w

7m.

v

MF:kt
‘EV’IIWIYSHW‘W

.

In"

pm

w.
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userum

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mm

«pm...

.~..,,

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rrv

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one.

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:w

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                    <text>Fawn-rwu‘w—ux

4y..-.'~r;-‘n.._.

..v.-

'a: wwwv .mu-nwm I“:~'€""’T“W¢k¥u"w§=7“m;m*'w ""m-.7"1‘9W""

.

.

'

v

,

“’

M “'

March 22, 1971
Dr. C. Paul Pascurosa
3301 East Ocean View Avenue

Norfolk, Virginia

Dear Dr. Pascaroaa:
Our programs in the study of narcotic antagonists in the
treatment of Opiate dependence are expanding, and we are inviting
clinical psychiatrists to join the program. Our training division
will make arrangements for those interested in specialized aspects
of psychiatry, so that you could obtain the eXposure to clinical
problems in addiction and the psychiatric training you seek.

support our study programs. We are unaware of any
fellowships that they have considered elsewhere.
FADA may

If you are interested in a training pragram with emphasis on
addiction, or a clinical position in addiction, we would appreciate
a copy of your curriculum
A
~'-'r'

-

vitae.

copy of one of our recent

reports is enclosed.
Sincerely yours,

ammz-uvna:wnw-r-r

Max
.‘n
u
-

MF:kt

‘y-grqu-m

,_..,~

var
_

“ﬁlm”

'~

m
‘

4""

‘

'J‘Pﬂ

um:

"II-‘WI'IIWWWW'I

.wrmva

Pink, H.D.

Professor of Psychiatry

W'vmn-nv'

enc

o

�</text>
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                    <text>March 22, 1971
Mr. Warren K. Smoot

Assistant Attorney General
Criminal

Justice Division

Chicago,

Illinois

188

W.

Randolph

Street (Suite
60601

2200)

Dear Mr. Sweet:
NIKE

The most

definitive source of data

on marijuana

is the recent

report, "Marijuana and Health", dated January 31, 1971.

Our studies are devoted to the effects of marijuana on brain
neurOphysiology. A summary of our latest study data, and a
"position paper" are enclosed. Our contract, for studies in Greece,

is in progress but no data are available now.
If you have more specific questions we will

our assistance.

Sincerely yours,
Max

Fink,

M.D.

Executive Director

HF

O.

kt

be glad to offer

�</text>
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                    <text>1

9

I

m»

«arm—xr‘mw‘wx-pus.mrv~w.w»-.rm'unwrmnmam

li-“iru'mr'ﬁﬂ- (v smwmmvntm‘m—wnm»,;

—~

r

“H'm‘r

"7|"!lkﬂmn‘yw

zr-v

~-

~-,—

w—m‘ :rv‘ﬁwt'ﬂ‘r Milt-run :r.

wmm-wm

m—w-.rv_m.wwum

‘Wmnn-VW;

March 22, 1971
my”

”up"

ml~n&lt;1uww~

..—~w«nv..p

Dr. Robert Petersen

National Institute of Rental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Bob,
had the need to refer to
the
report, "marijuana and.Eealth", and on each occasion found
concise, balanced and apparently complete. You and your associates
are to be congratulated on a fine, basic document - one which deserves
a wide distribution to scientists and students.

During the past few weeks,

it

HEW

Many

I have

thanks for making the capias available to us.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

..

r

z

w

1:,

-.

-9 ;

-

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                    <text>-WV

.{1

,_

-v

....,...A.,,‘,

Mardh 22, 1971

Acts Psych. Scandinavica

Munksgaard

Frags Boulevard 47
2300 Copenhagen

3. ,

Denmark

Gentlemen:
We

like to purchase copies of:
Supplement 213, by Laurell on Flurothyl
Supplement 215, by D'Elia on Unilateral

would

Are

these available,

and

at

what cost?

Thank you.

Sincerely yours,
Fink, M.D.
Executive Director

Max

MF:kt

ECT.

�</text>
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                    <text>Hutch 22. 1971

ﬁr.

C. C.

Elsosoor

aosoorch.ﬁanagcr

Jello Division

Gonsral Foods Corporation

Whito
Dear

Plains,

How

York

or. Elaoaoor:

In regard to the conversation I had with Mr. Fox on Wadnosday,
ﬁarch 17. 1971, I would like to clarify the situation regarding
naioxone. ﬁr. Fox was apprehensive about the Genital Foods Corporation
listed
having oaioxone in its possession since naloxonc is officially
as a Clasa A narcotic.
349~8030)
0n darch 17, 1971, I contacted Mr. Coatcrcllo, (212
Justice
the
of
Drugs
and
Dangerous
Chief of tho Bureau of Earcotics
of tho
informed
was
Mr.
Costcrello
Department for the ﬂaw York area.
Foods
General
the
in
situation and stated there would be no difficultyﬁe stated that the
Corporation having unloxonc in its possession.
of Paychiatry
corporation would be acting as the agent of the Department
of the How York Medical College.
This is an unusual situation becauso naloxono is notanda narcotic
has no
in the pharmacologic sense. It has no abuse potential,
Mr.
Cottorolio,
by
resale value. The Justice Department,andrepresented
has given aosurance that theta
is perfectly aware of the situation,
'9111 be no 10331 problem as for as the corporation possessing this agent.

the Rational Institute
In fact, the narcotic Addiction Control Commission,
about oxyloring
concerned
of mental ﬂoalth and the Juotioo Dooattmcnt are
dependence.
of
opiate
the usa of narcotic antagonists in tho treatment
you.wou1d
it
most
appreciative
Ho. along with those agencies, would be
palatcblo.
drug
make nvnilcbio your tachnicol skill in making this
annual
This roooatoh is oupportod by the Rationol Institute ofAddiction
Narcotic
York
ﬂow
Stat.
Hoolth, Grout no. MH-lﬂi?! and the
How York Hcdicol Collcgo
The
04‘116.
No.
Contract
Commission,
Control
4
a
5.
hold- a narcotic registry #62291 Class

�.

"away-T

.

.

m

77;

W‘~

“.mﬁV'VW—II‘

r-r‘no -/.»v.w' avg-«v.4:

cmrwrmwrmarwr,rx-u-m-W-wnw rr-z'wwr-

,~vr.‘..,v-M»-

“’75—34,wwvwmw—ymkum—rwv-v”:

-‘!VIN"."--v'4x~n':r'W‘hvwra

‘.;--—

4.." «3.

AV-- x

w «--vx..mwv--ns-&gt;.

,

«=7 - .—- «r ~vw—w

war

n.‘

gun-y

-.m.

Ji

n,

._,.

,‘1

rim—v

ﬁr. Elsasaor

~2-

March 22, 1971

Wa.',

'—w"lovv

It is becausa of the rapidly incranning problem of narcotic
addiction that raoenrch in this aroa ho: bacon: imperative. The
technical knovladse of your company would be a valuablo sorvioe to
tho community. It would allow rcnoarch to progress in one of tho
promising avunucr of rrnaruonr of this urgent public health problom.
We

hope

to hear

from you

shortly in this matter.
ﬁincercly yourl.
ﬂax Fink, M.D.

Professor of Psychiatry

Inks, Md).
Instructor in Psychiatry

Arthur
HF :kt

cc: ﬁr.

Law

vm-“V'WW'F

Ww‘mm-W

sac-71:»

tar

Pm

rat

W

:a..-wnymu

wry—mp

”Fl-:3;

'w
vl‘,

R. Y. Fox

Department

M.

wrw : m-vm-rsmv—“mn var-u»- ---

�</text>
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                    <text>March 22, 1971

Dr. Bartram Schiclc
77

Burton Avnnuo

Minncapolis, Hinncsotc
Door

Burt,

WWW.

A

WI-

‘

fcw months ago

on the proton:
My

state

I completed tho enclosed technical report
of the EEG program for psychopharaccology.

best regards.
Sinccrcly yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkt

�</text>
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                    <text>March 22, 1971
Dr. C. Paul Psecaross
3301 East Ocean View Avenue

Norfolk, Virginia

Dear Dr. Pascarosa:

in the study of narcotic antagonists in the
treatment of opiate dependence ere expanding, and we are inviting
clinical psychiatrists to join the program. Our training division
will make arrangements for those interested in specialized aspects
of psychiatry, so that you could obtain the exposure to clinical
problems in addiction and the psychiatric training you seek.
Our programs

support our study programs. We are unaware of any
fellowships that they have considered elsewhere.
FADA may

If

you ere

interested in a training program with emphasis

addiction, or s clinical position in addiction,
s cepy of your curriculum vitae.
A

copy of one of our recent

we

on
would appreciate

reports is enclosed.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kt

�</text>
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                    <text>T
“WVNW

wmw.mwy“m

“m

v-

v—v-

March 22, 1971

Acta Paych. Scandinavica

Hunkagaard

Praga Boulavard 47
2300 Copanhaaau

8.,

Denmark

Gantleman:
Wa

would

lika to purchase copiea of:

Supplamant 213, by Laurell an Flurothyl
Supplamant 215. by D'Elia on Unilateral ECT.
Ara thaaa

availabla,

and

at what coat?

Thank you.

Sincerely youra,
Pink, M.D.
Executive Director

Max

MF:kt

�</text>
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                    <text>Hutch 22, 1971
Mr. C. C. Elsoooor

Research.ﬂonogor

Jollo Division

Gonorol Foods Corporotion
White Plains, Now York
Door Mr. Elooooor;

In rogord to tho ooovorootion I had with Mr. Fox on Wodnoodoy,
I would liko to clarify tho oituotion rogordios
noloaono. ﬁr. Fox.woo opprohoooivo about tho Gonorol Food. Corporation
having noloxono in its pooooooioo since noloxono io officially listed
on o Class A narcotic.

March 17, 1971.

0:: march 17, 1971, I contootod Mr. Cootorollo, (212 349-8030)
Chiof of tho Buroou of Norootioo and Dangerous Drugs of tho Justico
Boportoont for tho Row York aroo. Mr. Cootorello was infornod of tho
situation oad ototod thoro would be no difficulty in tho Gonorol Foodo
Corporotion.ho~ing noloxono in its pooooooioo. ﬁo ototod thot tho
corporotion would ho ooting oo tho ogont of tho Dopartmt of Poydxiotry
of tho Nov York Modiool Collogo.

This is an unusual oituotion bocoooo noloxono is not o narcotic
in tho phornooologio oonoo. It has no obuoo potontiol, and has no
rooolo voluo. Tho Juotioo Doportnont, roprooontod by Hr. Contorollo,
in perfectly ouoro of tho oitootion, oud boo given aoouronco thot thoro
will ho no logol prohlon on for on tho corporotion pooooooing thin ogont.
In fact, tho Horootic Addiction Control Commission, tho ﬂotionol Inotitoto
of ﬂoatol Bonito ond tho Jootioo Bogggtooot oro ooncornod about olploring
tho uoo of narcotic ontogooioto in ti? trootoont of opioto doponoonoo.
Ho. along with thooo osonoioo, would be ooot opprooiotivo if you would
noko ovoiloblo your toohnicol okill in making this drug polotoblo.
Thio rooooroh io oupportod by tho notioool lootituto of Hontol
MH-18172 and tho Hon York Stoto Horootic Addiction
Control Con-iooion, Controot No. Gb‘llG. Tho Now York Medical Collogo
boldo o narcotic rogiotry l£2291 Clooo Q 5 5.

aoolth, Grout lo.

�Mr. Elana-or

Match 22. 1971

~2~

It 1. booauoo of tho rapidly inoroaatng problem of narcotic
addiction that roooaroh in this oroa has bacon. iaparazivo. Tho
technical koovladgo of your company would ha a vain-bl. oarvioa to
tho community. It would allow rooaaxoh to progrooa to on. of tho
proaiaing awanuoa of traataoot of this urgent public haalth problom.
Ho

hope to hear tron you ohortly in

this matter.

Sincoraly yours,
Fink, K.D.
Protooaor o! Poyohiotry

Max

Arthur

H. Zako, M.D.

Instructor in Psychiatry

H3:kt

cc: ﬁr. R.
Law

Y. Fax

Dopartaont

�</text>
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                    <text>March 22, 1971

J.

Mandela
V.A.
Hoepital
c/o
University and Woodland Aves.
Philadelphia, Pennsylvania 19104

Dr.

Dear

Joe,

a revised chapter, "The Electroencephalogran in
Clinical Psychiatry". Your comments were cogent, and I trust I
made the changes in a useful fashion.
Enclosed

(3)

but this

is

has been revised. It has been published elsewhere,
sinplified version can be published.
Table

1

controversial sections on pages 9 and 10 are indeleted.
a
These are useful for the specialist, but may have no place
(11)

The

textbook.

Unfortunately, there is no good data on the effects of
or PCPA on the EEG, and these must be obtained.

(14)

£~Dopa

Thanks again

for the excellent editing.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 22, 1971
Mr. Warren K. Snoot

Aeaietant Attorney General
Criminal Justice Division
188

W.

Randolph

Chicago,

Street (Suite

Illinois

60601

2200)

Deer Mr. Snoot:
NINE

The most

definitive source of date

on marijuana

is the recent

report, "Marijuana end Health", dated January 31, 1971.

studies are devoted to the effects of marijuana on brain
A summery of our latest study data, and a
"position paper” are enclosed. Our contract, for studies in Greece,
1a in progreee but no data are available now.
Our

neurophysiology.

If

you have more

our aaaistance.

specific questions

we

will be glad to offer

Sincerely yours,
Fink, M.D.
Executive Director

Max

Hr:kt

�</text>
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                    <text>Batch 19, 1971
Dr. Jonathan 0. Cole

Superintendent
State Hospital

Boaton

Boston, Massachusetts
Dear Jon,

Peter Irwin and Nick Pavel visited 383 on Tuesday. They
reviewed the recording methods and recalibrated the equipment,
so that other records will be analyzable with ease.
Enclosed are the transportation stubs.
If not, will cover with our funds.

thanks.

my

If payable,

many

best regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

MFA“:

one .

�</text>
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                    <text>:m ymr—m

F—zmrw—uw
W1"

_.-,...—

:

v

.

-

.. , ya m ..x..,

W

,4 . » ‘

mm

,

.r .

--

,

,

.

.

mnxm..y..u.~v—w.wmxwv
,

.

mm‘wmrnv—pupmr

March 19, 1971
K.

E. Page, Dept. Dir.

Jails

Prisons Div.
Office of the Sheriff
Consolidated City of Jacksonville
P. 0. Box 2070
Jacksonville, Florida 32202
&amp;

Dear Mr. Page:
We can accommodate your kind invitation to
present our
work at the F.C.C.D. Conference on June 24, 10:30 e.m. to 11:45 a.m.,
in Hollywood, Florida. I believe that I may be able to attend, but
if I cannot, Dr. Richard Resnick, Assistant Professor in our Department,

will present our report.

Narcotic Antagonists: A Rationel Approach
to Opiate Dependence
The authors, if you wish to list them, are Mex Fink, M.D., Alfred
Freedman, M.D., Richard Resnick, M.D. and Arthur Zeke, M.D.

Again, our thanks for the

invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

Hszj

M.

«x.

r

m

�</text>
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                    <text>Hatch 18, 1971
Dr. Ibrahim S. Turak
Maryland Psychiatric Research Center
Box 3235

Baltimore, Maryland 21228
Dear Dr. Turek,

will

We

be

have many

reprints, beginning in 1953.
relevant to your studies are enclosed.

Good

The ones

that

luck!
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

�</text>
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                    <text>March 17, 1971

Dr. Theodore D. Langley
Research Neurophysi‘ ogist
Ocean Systess, Ines

Tarrytovn Technical waster
Tarrytown,

New

York £0591

Dear Dr. Landlay:
The dean of our graduate school,¥Dr. Tabachnik sent us a capy
of the biographical sketches of Ocean Systems employees. The note,
that you are developing "a computerised systes for recording and
analyzing brain waves" interested me. Two units of this Department
are actively involved in such work. '

interest is in_relating changes in the background
EEG to dose, type and duration of
drug
adninistration.‘ Our system is based on an IBMJIBOO control computer.
Our own

alert (or sleeping)

report is enclosed.
Dr. E. Roy John, also in this Department, analyses the responses
evoked to repetitive stimuli, and uses the PDP—lz.
A

copy of a recent

If either system may be related to your work, or that of Ocean
Systems, I would be pleased to hear from you.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

M?:kt

cc:

A. M. Freedman

Dr. Tabachnik

�</text>
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x.

w“...‘wv—. fwwv.’vw’inn-wrpgw. r-‘nvmm—

_

.

_

.w. :J»vl
“a“.wn—ﬁw:.‘-~v-mw.-._.—v-~....—w—w

VrIVw-mem’"

—--o«

March 17, 1971

Corporation
c/o Data~Rep Associates Inc.
Ampex

P. O. Box 164
Huntington Station,

Attention:
Dear

New

York 11746

Mr. E. P. Nelson

Sir:

Since delivery of the magnetic tapes, ordered February 23,
has been delayed beyond a reasonable length of time, I am hereby

cancelling the order.

Sincerely yours,
~16"

,

Max

MF:kt

.,

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‘_

,1

.

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..

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«1:;

urn-mn-l-R'VFLIIWJW‘H'w-.-‘1'$

"1",

”now-mu-

Fink,

M.D.

Executive Director

-y..-“-v.ww».

~u-cm:~usu-~u~vw

�</text>
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                    <text>wzvi-l‘t'n‘rwﬁva-upt-“VVJV1....

....,

.._. 7.,

.w

.

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my W.

.-.».,¢....1,..W.

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q

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,

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,

www—

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v."

m

March 15, 1971

—._.,,~._.....wr-A.

.hwrwn...“

American Association for the
Advancement of Science
1515 Hasaachusetts Awe., N.w.
Washington, 3.0. 20005

m-....,.«_'

”my?”

wm—wuwwwmw

w“

Gentlemen:

I am writing with regard to invoice M74709f for 500 reprints
of ”Narcotic Antagonists in Opiate Dependence”, in September 4, 1970.
The invoicc is for $90.00.
According to our records, the reprint request was submitted in
July and at that time the estimate was $36.00.
would appreciate your checking your records
the invoice.
for
basis

I

and

verifying the

Sincerely yours,

WW&lt;

u’hwvvrﬁov

Max

Pink. M.D.

Professor of Psychiatry

Mr:kt

�</text>
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                    <text>March 15, 1971

3. Stewart
Administrator
Sydney City ﬁospital
Sydney, Nova Scotia

Mr. H.

Dear Mr‘ Stewart:

resident in training at the Missouri
or 196A. During his tenure he
of the effects of high dose LSD
in
a
study
participated actively
of
co~outhor
and
our peport on "Prolonged Adverse
was
in psychotic:
LSD
published in 1966. He
Subjects",
in
Reactions to
Psychotic
Dr. Waheedul Hague was 1

Institute of Psychiatry in

left

1963

after completing this study.
I recall, he was reliable, interested in his work,

soon

As

participated actively in our program.

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

Max

MFhkt

and

�</text>
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                    <text>nag;

“w”,

a

Hatch 12, 1971
Dr. Israel Kesselbrenner
Kirby Manhattan Psychiatric Hospital
Ward's Island
New York, ﬂew York 10035
Dear Res,

while I know you have notes of the various topics discussed,
I should like to summarize our meeting.
the

Over the next few weeks I would like to meet with members of
staff and gradually introduce the new members coming from the

Department.

As I understand it. parking is no problem; cards for meals in
the main dining room will be made available to those who are on the
State payroll; a clerk secretary will be designated as a liaison for
those of us from the College; and the following personnel will be
put on the State payroll effective March 1: Fink, Gaztenaga,

ibrhiéahli, Durbin,

Abrams .

With regard to offices, I will try to negotiate the use of one
of the examination rooms for a laboratory; and you have made three
rooms available. It is my expectation that as soon as I understand
the various rules of the staff, I will request reallocation of space
using these three rooms as the basis for "musical chairs". I anticipate
that you will make a suitable office available for my use this uehk.
If possible, I unuld appreciate your requesting a direct telephone line

to this office.
Thank you

for your cooperation.Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>March 12, 1971
Dr. Charles Shagass

Eastern Pennsylvania Psychiatric

Institute

Philadelphia, Pennsylvania 19129
Dear Charlie,
We

have checked the

called Fritz Freyhan,

who

files for

By-Laws. We found none and
had
he
said
no knowledge of By-Laws.

If we are to follow precedent. an increase in the dues would
require Council action, followed by approval by the membership at
the next annual meeting.

You may wish to suggest appointment of a constitutional
committee which could formulate By—Lawe of a more general nature.

For the past few meetings of Council, chairmen of various
committees have been invited to the meetings. Fritz reminded me
that these men are not officially part of Council. As the meeting
broke up, Ron Fieve asked me if he was a member of Council and,
if so, should his name not appear on the stationery. I would
suggest that this is another "constitutional" question which could
be referred to a committee and be made either as a modification of

the constitution or part of the

By~Lewa.

Sincerely yours,
Fink, M.D.
Vice-President

Hex

MF:kt

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                    <text>r

v.7.‘wvmmr-

m .‘u- mm v

,

».

.--a———yw.~..-..»;..,~_.ma: w.-m—w:mw.umw.w~xm

me-

“r‘WWhﬁmvww-ms-m&lt;ww'wnrw~

»

——v--

,

V

March 10, 1971
Miss Loretta C. Kelly

Director of Sales

The Castle Harbour
Bermuda

Dear Miss Kelly,

are interested in a meeting this fall, but our
committees
will not meet until late April. We have
planning
received your descriptions and these will be considered at
We

that time.

Sincerely yours,

E

E

E

Fink, M.D.
Executive Director
Max

g

2

g

:

.

w

.,—

—mmwmuu~m

‘wv-wu—vzv... mm

Mszt

m A...“ ,

y

w I‘M-Iv

u"

�</text>
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                    <text>.M. w—w.V.r,.m«.._-wTr»-..

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March 10, 1971
Mr. Richard Mattaschiam

Assistant Coordinator

of Research and Communications
Service for Education &amp; Rehabilitation

in Addiction

1014 Hoe Avenue
Bronx, New York 10450

Dear Mr. Mattaschiam:
I am enclosing a copy of a recent summary of our experimental
work with the narcotic antagonists. The work is still experimental
and not applicable to the general treatment programs.
Good luck

in your efforts.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
8316.

-

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                    <text>-

‘

W""""'~&lt;‘~~-...~..v.",--

&gt;'v:'

v.5.

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{

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a

Mardh 10, 1971

Miss Linda Davidhoff
°

i

Veterans Administration
Mental Hygiene Clinic
803 S. Saline Street

Syracuse,

New

York 13202
ma;

Dear Miss Davidhoff:
E

670-116A

no
for help was received. There has beenread
have
I
and
further study of lactate or prepranolol here,
no recent reports.
For your patient, the use of thieridazine is to be
function.
questioned since it has adverse effects on cardiac
Your request

ECT, or
Perhaps your consultant would consider a trial of
agent
anti-anxiety
doxepin - the latter being the most recent

to

be made
I

recommend

available.

regret that

I do not accept

referrals, but could

physicians in this department, should you wish to

have your patient seen in

New

York.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

3

Mszt

in,~e- mm "0 ’«W‘xw- »m.
.,

,

.,.~ ,

.1

.- ,.

H. v

�</text>
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                    <text>March 10, 1971

Dr. Max Streifler
Head, Department of Neurology
Municipal Governmental Medical Center

Ichllov Hospital
Tel-Aviv, Israel
Dear Max,

Your kind invitation to attend the conference on prolonged
drug usage and the fetus was most welcome. I would like to attend,
as the problem is a critical one. My laboratory, however, has no
data on this Iroblem and we will be unable to contribute to the

proceedings.

may, however, be able to send an observer, and I would
appreciate a capy of the definitive program when it is available.
We

profiles of psychoactive drugs have been successful
in classifying some new drugs (thiothixene, cyclazocine, doxepin),
Our

EEG

in showing the bioavailability and equivalence of two dosage
forms of doxepin, and of the capsule and concentrate thiothixene.
We are now studying some new, numbered drugs and believe the
technique will have more general applications.

In addiction research, we are the principal agency studying
the narcotic antagonists (cyclazocine and naloxone) for Opiate
dependence; and, because of our local concern, the neurOphysiology
of cannabis.

It is

a busy time, and

if

I can reach Israel in September,
I look forward to seeing you

I will try to audit the sessions.

again.

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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“my”. xrr—rF-

-..

i...» .ww—nnq~-~vmv'vrw:s&lt;"wx"'ls—

u

w

..u...

March 10, 1971

“......"

V

"wan—"Mr

v“

..V.

,

Dr. Ali Keskiner

Missouri

Institute of Psychiatry
Street

5400 Arsenal

St. Louis, Missouri 63159

vmnr'vw'w‘

“TVA‘V'W-wv'm-r-U-Wmmrvmrwmmu’r

Dear Ali,
Enclosed is a copy of the text of the exhibit in Anaheim.
There should be available printed copies of this text, as well as
a notebook for requests for reprints. The actual reprint from which
this data was taken is the report that appeared in Compliehensive

of which is enclosed.
will tell you, he is taking

Paganini/Ly, a copy
As Don

you
me

my

place because he would
I will not meet

in California. I am sorry
this time, but look forward to seeing you soon.

like to spend a
and

Please

I

My

few dwgs

a statement of your expenses and send them to
will see that you are fully reimbursed.
make up

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mas:

MP:

kt

Happy

Birthday!
Kathy

'

»~—-.

~

~

.L

‘WV‘r-‘nWI-J-n

“....

�</text>
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                    <text>March 10, 1971

Dr. Jay P. Kirkpatrick
Division of Science and Mathematics
Eastern Montana College

Billings,

Montana 59101

Dear Dr. Kirkpatrick:
The address

that of the Federal

of

FADA

is

36 West 34th St., New York, New York;
is 5600 Fischers Lane, Rockville,

Bureau of Drugs

Maryland 20852. Enclosed is a report from Science which summarizes
our knowledge of the antagonists in opiate addiction.

Sincerely yours,
Max

Fink ,

M.D .

Professor of Psychiatry

Mszt
enc.

�</text>
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                    <text>March 10, 1971

Dr. Hans

W.

Kosterlitz

Department of Therapeutics and
Pharmacology

University of Aberdeen
University Medical Building

Foresterhill,

Scotland
Dear Dr.

Aberdeen

Kosterlitz:

Our contribution to the ”Symposium on Agonist and Antagonist
Actions of Narcotic Analgesic Drugs” in Aberdeen will be:

Clinical Studies of Cyclazocine

and Naloxone

in Treating Opiate Dependence

Max Fink, M.D.*, Alfred Freedman, M.D.,
Richard Resnick, M.D. and Arthur Zaks, M.D.

I
I

trust we will be able to obtain the funds
will write again.
The program

participating.

You

and

if we

are unsuccessful 9

is an excellent one, and we look forward to
will recommend hotel accommodations when

arrangements are made.

Again, our thanks for the

invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt
"0'"va

«an:

w

‘

cc:

Dr. Freedman

�</text>
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\l—I“F7ww1\ ..-.‘

V»

..

w...

m

March 10, 1971

”3-w-

*-u'vrtv_4

vw-r—v:w,n-:gw~w~

Dr. Jay F. Kirkpatrick
Division of Science and Mathematics
Eastern Montana College

Billings,

Montana 59101

Dear Dr. Kirkpatrick:
The address

that of the Federal

of

FADA

is

36 West 34th St., New York, New York;
is 5600 Fischers Lane, Rockville,

Bureau of Drugs

Maryland 20852. Enclosed is a report from Science which summarizes
our knowledge of the antagonists in Opiate addiction.

Sincerely yours,
Max

Fink, “.0.

Professor of Psychiatry

MF:kt
GDC .

�</text>
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""‘

" "~""" "“""

.,,.,....w_

r

v

hard.

10, 1971

Mr. Richard Mattaschiam

Assistant Coordinator

of Research and Communications
Service for Education &amp; Rehabilitation

in Addiction

WW."

Wu

-

1014 Hoe Avenue
Bronx, New York 10459

._.

a.

-—-‘-

"ﬁr...

..

mu.-

v—

.wa—

Dear Mr. Mattaschiam:
I am enclosing a copy of a recent summary of our experimental
work with the narcotic antagonists. The work is still experimental
and not applicable to the general treatment programs.

‘rnwe—

Good luck

..

in your efforts.
Sincerely yours ,

wwwprx..-‘

nan-p

"a."

Fink, M.D.
Professor of Psychiatry

Max
-w.yw&lt;.4-w~—N-1~:nq—u

-.—-

Mszt

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"quay“.

mum

«puma.

urw-Wm-

arr-"w-uvm-me-nwmy—a

ws-v

mem~w~wwunWW-rvv,avwvuww

831C.

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r:

‘mv we...

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"'17—.

.. y“

.

,

~

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;

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H'v

u»

,

mmlm"

p

)mrmlwmww‘w.

71m..- r.“ m.‘ ”Jr-wan.»

{\
Q)?

March 10, 1971

Miss Linda Davidhoff

Veterans Administration
Mental Hygiene Clinic
803 S. Salina Street

Syracuse,

New York 13202

Dear Miss Davidhoff:

RE:

670-116A

Your request for help was received. There has been no
further study of lactate or propranolol here, and I have read
no recent reports.
For your patient, the use of thioridazine is to be
questioned since it has adverse effects on cardiac function.

Perhaps your consultant would consider a trial of ECT, or
doxepin - the latter being the most recent anti-anxiety agent
to be made available.
I

recommend

regret that

I do not accept referrals, but could
physicians in this department, should you wish to

have your patient seen in

New

York.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

r

.v;~

r- --—\

v «raw—r
v

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