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                    <text>v

"In-1"!-

October 14, 1970
Dr. Jack Freund

A.H. Robins Co.

Richmond, Virginia

Dear Jack,

I am enclosing a copy of a letter from P. Bornnstein and
the reprints that he sent in response to my request for data on
sulpiride. In reading the papers I find littla that I have not read
before. The EEG data is, unfortunately, non-quantitative and less than

definitive.
to

My

interpretation of this data is that it adds
you posed regarding sulpiride.

clarify the questions

little

I trust this is helpful.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>October 13, 1970
Dear Ernst,

Separately, I am sending you half my supply of
and
enclose two essays of the material. The assay by
hashish,
Coy Waller is probably correct; that of Miran probably underestimating
the content.

for citing the source of the material, you should
feel is best. The material was imported by me, under
a federal permit, for research studies in man. It is derived from
Athens, and is considered a grade "B" or "3+" hashish. If you wish
to give credit, it is from the supply of the International
Association for Psychiatric Research, imported in 1969.
do what you

As

Good lung

in your studies.
Sincerely yours.
Max

Fink,

M.D.

�</text>
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                    <text>October 11, 1970
Mr. Nicholas Johnson

Commission
Uashington, D.C.
FCC

Dear Mr. Johnson:

Congratulations on your einellent report in today's New York Times.
to divide the country, and to intiﬁidate the
networks than any man in this century.

Mr. Agnew has done more

It is particularly refreshing to see alcohol

and tobacco put in
dominant
of
the
drug killers of our
their prOper perspective, that
As
and
worker
research
in
a
a principal exponent
generation.
Opiates,
of the narcotic antagonism approach to opiate dependence, Ilave been
repeatedly angered by audiences and politicians who insist that heroin
and Opiates are the principal killers. Mr. Agnew's identification of
youth and the anti-establishment with Opiates and with cannabis is a
P.R. ploy, and your article is the clearest statement against such a

divisive program.
Again,

my

congratulations,

heard from the Commission.

and I hope

that your voice is indeed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>October 11, 1970
Dear Dick,
The 8-10 p.m. slot is fine. As for the additional
slot for “less formal interactions", I would hesitate to
commit myself—— after all, the daytime was meant for skiing, and
I suspect that the after 11 p.m. time will be the best for

daytime

interactions.

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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"T
«W

w

October 9, l970
Dr. Rafael R. Gamso
Director of Medical Services
Narcotic Addiction Control Commission
l855 Broadway
New

York,

New

York l0023

Dear Dr. Gama:
Thank you again

sessions.

on

for the invitation to address the

the schedule:
Fink

égksi c k
sn

at l855

2/lB/7l
3/lS/7l

ﬁfief¥l~sg

10:00 a.m.
"
"

Broadway.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kt

cc:

Dr. Rasnick
Ir. Zaks

NACC

training

�</text>
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                    <text>Four"): my w. mr nava—mv-w-w—wa“

'

--

Wm v”&lt;' w. mow-aurrwvwwvr me-jy .FuuﬂWLmI—w—u—rmu,

w-‘m

~~

vw m-V‘I.V'.
.

w

ku Jr Wmprrmrw'i",

7-.

V

w

.

_

October 9, 1970
Dr. Louis Harris
Department of Pharmacoloqy
University of North Carolina School

of Medicine

Chapel

Hill, North Carolina

Dear Lou.
As we

discussed,

we now

have a supply of

M-SOSO

and would

like to undertake single dose trials in man to assay the duration
and degree of antagon
3m to injected heroin.
If these are
successful, we would assay chronic oral dosages (2-4 weeks) and
assess the degree of antagonism; and then develop a parenteral
formulation, hopefully of long duration.

abide by prevailing practice, we will need animal toxicity
file for an IND. Our letter to the FDA is enclosed. I
would value your opinion as to what is needed. Can you
out
the project? At what estimated cost. for we would like carry
to present
such an estimate to the New York State Narcotic Addiction Control
To

data to

Commission.

I look forward
My

to seeing

you in Puerto'Rico.

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt
enc. Letter to

FDA

Science summary.

�</text>
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                    <text>an

MVP

T0:

Mr. Thomas Bannon

FROM:

Max

As we

Fink,

October 9, 1970

M.D.

discussed, the enciosed

PD-4 forms

refiect salary

adjustments for research assistants of various types, occasioned
by the equivaience of their duties and quaiifications with union

personnel.

we

will

I

fear that if we fail to make some adjustments,
larger saiary demands in a short time.

be faced by

Piease advise.
Many

kt

thanks.

�</text>
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                    <text>wwmu‘w'w

.v

~

-,..._..,_.,—._.....—

m.__w_~.&lt;..m«

“.mwm‘w

October 9, l970
Dr. Joseph Bird

Sterling Winthrop Research Laboratories

90 Park Avenue
New York, New York

Dear

l00l6

Joe,

Enclosed are the available
program.

new

case reports in our cyclazocine

study is progressing well. we now have 52 patients in the
induction schedule is most satisfactory.
clinic..
The

The 4-day

I am

meeting.

also enclosing

a

reprint of the

summary

of the June

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

MF:kt

4

A

»

�</text>
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_

,

.,._»“»‘w

-

7

,

,ws

_

-'

v

,

V

.

,.

17...,

w-

...

mu,“—

October 8, 1970

"m“

YVn—w-

WW.

;

i
3

Dr. Richard Steinbeck

Professor and Chairman
Georgetown University Hospital

3800 Resevoir Road, N.W.
Washington. 0.0. 20007
Dear Dr. Steinbach:

Dr. Amelia B. Donesa is an internist who joined my staff
in 1967, and served until 1969. While working in our drug
evaluation programs, she became interested in clinical psychiatry
and began her residency training here.
She

is bright, enthusiastic

and

comprehension and speech are good.

I

am

pleased to

recommend

friendly.

Her language

her continued training in psychiatry.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt

w:—

,

«wavy—wry“.

�</text>
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..--

..

.vyv-

Octobar 8, 1970

"m

‘.
v-

_._.—r--,

.2JWW‘

arm,

WW,"

Miss B. Scott
Now York State Narcotic Addiction
Control Commission
1855 Broadway
New York, Now York 10025
Dear Miss

Scott:

Enclosed are the summaries of the meeting on narcotic
antagonists of June 4, as published in Science.

I wan. to thank the

support.

Commission

for their interest

and

Sincarlly yours,
Max

Fink, M.D.

Profesoor of Psychiatry

Hrzkt

�</text>
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‘1‘

mn my." ,,,, ... ..

October 7, 1970
Dr. Dorothy Dobbs
Food and Drug Administration
18733 Walker's Choice Rd.
Gaithersburg, Maryland 20760
Dear Dr. Dobbs:

to
writing to ask your advice as to the steps necessary
M 5050
new
narcotic
antagonist,
undertake human assays of a
I

am

—

diprenorphine.

Since 1965, we have been interested in treating opiate
a
dependence with narcotic antagonists. This therapy is based onwhich
and
Martin
Lexington,
Wikler
at
theoretic model, developed by
views opiate dependence as a psychological and physiological conditioning,

requiring

an active

extinction of conditioned responses for successful.

therapy. Following their lead,
as therapeutic agents.

we

have assayed cyclazocine and naloxone

short duration of action of both drugs has led us to seek
ways of extending their action, including the development of silastic
implants, in which duration is related to the rate of leaching into
the tissues and the amount of drug in the implant. Since amount of
drug and size of implant are directly related, we are seeking as
potent an antagonist as we can find for this purpose.
A

June 4 we convened a conference to review the available
by the
clinical and pharmacological data, and were heartened
developing
for
of
suggestions
clinical reports and by the variety
a long acting formulation.
On

V

discussant led us to M-SOSO, a narcotic compound produced
by Reckitt and Colman of Hull, England. In animal assays, it is a potent
has reported it to
antagonist without agonistic properties. Villareal
Colman
and
are preparing
Reckitt
naloxone.
be 16-20 times as potent as
narcotic M-99
with
a
potent
- very
to market this compound in a package
medicine.
to control large animals in veterinary
One

data, nor are they now interested in developing
the compound for human use. They are willing, however, to make supplies
available for our assay, both in animal pharmacology and clinical.
They have no human

�.,

.

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r

“igummww .

-,

:9

mama- mum rum

wane-m1 :‘

"V‘mmfwf‘wﬁmmwrmv'ww

Dr. Dobbs

-

;“ nmmlr’lv‘wﬁww rummrwwww-w W‘r—wwizﬁ-Im»)"
w

|~

October 7, 1970

~2-

Our research program is supported by contracts from the New York
State Narcotic Addiction Control Commission, and we believe they will
support this project.

I am writing to ask your advice and assistance in formulating the
animal toxicology data prerequisite to our proposed clinical assays.
We would first determine if M 5050 is an antagonist to heroin, at
what dose, and for what duration after a single dose. If antagonism is
demonstrated, we would then define the oral or parenteral dose necessary
to produce continuous antagonism to heroin. (In this study we would
parallel the assays we have made of cyclazocine and naloxone.)
We

Enclosed are copies of all the data on M 5050 available to us.
also have an initial 10 granssupply for study.
What

additional data are necessary for us to file for single dose

assays in man?
we fol low?

What

toxicology data are needed?

What

procedures should

In addition to the M 5050 data, I am enclosing a summary of the
meeting as published in §gigngg; and reprints of our studies
of cyclazocine, naloxone and heroin, that will provide the background
for our interest in this program.

June

4

If useful, I
this request with
Many

would be pleased to visit your
you and your associates.

offices to discuss

thanks for your help.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

cc:

A. M. Freedman, 24.0.
H.

M.

Meiseles,
Luger ,

NACC
NACC

wuov'n - are "rm—Iva.

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FJYN w... . m..-y-_.m.m"W.—mumw-uI-w'rm
,

,

_

WW

'1-

October 7, 1970
Docteur Nourricier
Laboratorres Delagrange

Madame 1e

la Tour Manbourg
France

39 Blvd. de

Paris

E

—

WW‘WW""“

,

Dear Dr.

Nourricier:

For many years I have been interested in the

analysis
psychoactive drugs. Earlier this year, sulpiride was
brought to my attention as a compound with clinical psychotrOpic
activity but without the usual pharmacologic profiles. At the
GIMP in Prague, this interesting discrepancy was confirmed in
discussions with Professor P. Simon.

of

&lt;

'I'8

EEG

new

—~c—--.-v&lt;v

request, he has sent me some data from his files,
suggesting that I write to you for a more complete record of
investigational data. I am interested in the basic pharmacology
data and available clinical data as usually supplied to
investigators prior to clinical studies. I am writing to ask if
such information may be made available to me, as the basis perhaps
At my

«awn—«mm-w—p—

WW-..—

vap

w.

._

_.

of a clinical or

EEG

profile study.

To provide a reasonable background for this request, I am
enclosing a copy of my 1969 BBC review which is the basis for
our studies.
Many

thanks for your consideration of

this request.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

’

�</text>
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                    <text>.

-mvw':‘nwu rm“.

ww-vym

October 7, 1970
Dr. Gerald L. Klernan
Harvard Medical School
Massachusetts General Hospital
Boston, Massachusetts 02114
Dear Gerry,

enclosing our reports on cyclazocine and naloxone and our
The summary of the June 4 meeting is all that is available
and will not be published separately. The meeting was a workshop,
designed to assess the state of the available knowledge and to chart
the needs for further study.
I am

pre-rints.

Since the meeting

have:

we

to continue to
available for research;

1)

Moved Endo (DuPont)

2)

Contracted with

3)

obtained

4)

stimulated a contract application from Alza Inc.
for a long acting, non—silastic device for naloxone; and

5)

set

make naloxone

Food and Drug Research

of

New

to develop a silastic implant for naloxone;
M

5050 from England and are

filing

York

an IND;

up an unofficial commission, headed by Al Freedman
and William Martin to stimulate further study (and

seek funds!).

It

before

would be a pleasure

my

next

trip,

Many

to visit

you in Boston, and I

thanks for the

invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
011C .

will call

'Wﬁw‘ W

---

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                    <text>«-

"xv’ﬂy'rm‘l mum-warp»:«Irv-warn.

v stoma-navy

Nirvana-slurr-wuw-srv-n .r

x w» mm

wow-w

“Mm'xr‘wﬁyv

2

{Inner

nunvv-w-msrv»

w-v- ‘wvnm-rmxmwvw

-

v-v

-

v

unmvr

two-w

w

"ma”‘ﬁw’WAWVW—www

October 5, 1970
Dr. Stephen Bernstein
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Steve,

Separately I am sending you a dozen each of recent reprints
published with the support of MH-l3358, as requested in the recent
ECDEU

Intercom.

Incidentally, you are to be congratulated
issues. My staff and I read these issues with
may

on the

much

first

two

interest.

There is one problem. recentty brought to my attention that
be discussed by the ECDEU investigators with some profit, that

of the compensation of subjects injured in our studies. I am
enclosing a thoughtful article from a recent issue of Science.
This has become particularly important as more investigators are
assessing drugs in normal subjects (B. Goldstein, T. Iti., L. Goldstein
and C. Pfeiffer, myself); in ambulatory outpatients (Rickels, Wheatley.
Engelhardt); and in children and adolescents (Engelhardt, Connors. Fish,
Simeon) - papulstions which provide unique ethical considerations.
The issue was once discussed at length by the Clinical Committee
(1961 or 1962) but no action was taken. Perhaps, a review is
indicated at this time.
My

best regards.
Sincerely yours,
Has Fink, M.D.

Professor of Psychiatry

HF:kt

encs: Havighurst: Science,

10

July

70

»

~

....,._._,. v

v

'V

.

�</text>
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                    <text>October 5, 1970
'7‘7‘01‘a'

mu-‘mn‘r-u-vrv—r

Dr. Jerome Levine
PsychOpharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

V'V'I‘w-o

Dear
-r—wvww7ww

-

z

,&gt;

2..

.7.

-.

Jerry,

For the past half year, we have been pre—occupied with our
assessments in a variety of studies, each designed to define
useful techniques. Preprints are enclosed, as these studies have
not yet been published, and will serve to describe the state of
our art.
EEG

wm-,-,.

.,...,,..,,.,

5-0-

w.
s

For two studies, comparable data from other investigators
are now available. Pfeiffer and Goldstein assessed S 421548 in
volunteers using their amplitude integration techniques; and
Dement and Kales each evaluated GP 41299 in separate sleep studies.
If these may be useful to you, I will send you cepies.
thanks for your patients and
techniques of drug classification.
Again,

my

interest in the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
011C.

EEG

�</text>
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                    <text>October 5, 1970
Dr. Oscar K. Diamond, President
New York Society for Clinical Psychiatry
New York County District Branch
American Psychiatric Association
250 West 57th

New

York,

New

Street,

Room 500

York 10019

Dear Oscar,

organized last year to answer a specific
the
question (methadone) we organized an ad hoc
for
committee. I would be pleased to continue as chairman, to organize
a committee as the need arises.
The Committee was

need, and

(Sid and I) considered a committee that would try to
review overall policy problems of the society with regard to of
decided that the role
biological aspects of psychiatry, and well
defined as not to
was
sufficiently
biological therapies
maintenance,
methadone
for
review
except
require a committee
ad hoc
the
to
was
satisfactory
model,
which, as a research
committee and the society.
We

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mrzkt

�</text>
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                    <text>&lt;

‘-&lt;-r‘wl.’v

October 5, 1970
Hhitmore Jensen, Vice President
Ayers: Laborstories
685 Third Avenue
York, New York 10017

New

‘

Deer Mr. Jensen:

It is

with regret that we must pert - I have enjoyed Ayerst's
and the novel manner of sending them. The first day cover:
were attractive, (I have them all, although I am not a philstelist)
end brought your message promptly to my strention.

letters

Ave

atque vale!
Sincerely yours,
Pink, M.D.
Professor of Psychietry

‘Mex

HP:kt

�</text>
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                    <text>October 5, 1970
Dr. William Vogel
Worcester State Hospital
Worcester, Massachusetts
Dear Hr. Vogel:

title ”Effects
EEG
Performance of
Mental
and
the
Infusions
upon
of Testosterone
Normal Males." We are particularly interested in drug induced
EEG changes in volunteers and the relation of these changes to
behavior, both in the normal and in mentally ill.
In reading the program of EPA, I noted the

If

to read

a preprint

it.

Many

is available

I would appreciate the opportunity

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>January 29, 1971
Dear Leo,
I will be pleased to chair the session on CNS drugs
scheduled for Saturday, May 1; 1eaving up to you the feasibi1ity
of being in two locations at one time.
Many

,

thanks.
Sincerely yours,

“W4‘

“‘7'

wit-“*1

van-Wm.

m"?

'n
'

Max

Fink, H.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106084">
                    <text>January 28, 1971
Dr. James McGaugh

Department of Psychobiology

University of California at Irvine

Irvine, California

92664

Dear Jim,

draft copies of the proposal for our
conference. I would be grateful if you would edit one and
return it as soon as practical.
(1) Please check the text for a summary of our
Enclosed are two

ECT

recommendations.
and

,

invitees should also
notes to delete are invited.
(2)

The

(3)

Please add

(4)

Any comments on

.

A,

..

work done".

._.

.

_..

.

3~5

be reviewed and

citations to the list for “previous

,1.

.,.»

W1.

.1”

the provisional budget?

-

My

thanks for your guidance and sound advice.

arm—wrnv—rvz'm

Sincerely yours,
.

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc. (2)

additions

�</text>
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                    <text>”iv-ramm-

-l

January 28, l97l
Dr. Seymour 5. Katy, Director

Psychiatric Research Laboratories

Massachusetts General Hospital
Boston, Massachusetts 02ll4
Dear Seymour,

draft copies of the proposal for our
grateful if you would edit one and
as practical.

Enclosed are two

conference.

return

it

I would be

as soon

ECT

(1) Please check the text for a summary of our
recommendations.
and notes

(2) The invitees should also
to delete are invited.
(3)

Please add 3-5 citations to the

(4)

Any comments on

work done”.

My

be reviewed and additions

list

for ”previous

the provisional budget?

thanks for your guidance and sound advice.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

enc. (2)

�</text>
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                    <text>7,...”

,_

-

...

.-

a,

.

.

..

... . “W“.

:—

ww

mm.-.

.

-

i.

.

T-.

.,

_,...

.91..

,

.,.

1

‘

“gaunt—wwmmw

-

a

.

,

.,

..

n

,

”(v

..

in, “,7..-

January 28, l97l
Dr. Thomas Williams
NIMH~CRB

5454 Wisconsin Avenue
Chevy Chase, Maryland 200l5
Dear Tom,

draft copies of the proposal for our
grateful if you would edit one and
as practical.

Enclosed are two

conference.

return

it

ECT

I would be

as soon

(1) Please check the text for a summary of our
recommendations.
and notes
V

a.
V

.

.
A

(2) The invitees should also
to delete are invited.

be reviewed and additions

(3)

Please add 3-5 citations to the

(4)

Any comments on

work done”.

list

for "previous

my

.,...

..

,A.

.5.”

My

the provisional budget?

thanks for your guidance and sound advice.

Sincerely yours.
mwwwrmiw’vvvwvr(“w"ﬂ.wvwh’wyu

Max

Fink.

M.D.

Professor of Psychiatry

MF:kt

enc. (2)

�</text>
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                    <text>v

.m

any.”

w"

mm

January 2!, 1971

m

“VJ-r...

UFWWSF’WWHWW

Dr. William Tabor

A. H. Robina Company
1407 Cummings Drive

Virginia

Richmond,

Dear

Bill.

have received the ARR-1118 date and find that single
doses of 200 mg seem adequate to produce an EEG change. To
verify this, however, I would like to run a few single trials
at higher doeeges, Specifically 250, 300 end 400 mg. I would
like to run two to four experiments at each done.
We

Our

data to date

show 200 mg

well tolerated by volunteers.

(:6 3.4

mg/kg) are

safe

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mr:kt

and

�</text>
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                    <text>January 27, 1971
Dr. Virgii P1ace

A1za

Corporation

950 Page Mi11 Road
Pa1o A1to. Ca1ifornia 94304
Dear Virgi1:
Fo1lowing the intrusion of New York City into the search for
a 1ong—acting antagonist, a 1ay organization. FADA (Federation
against Drug Abuse) announced its fund raising program focussed
on a “positive" approach to drug addiction. They became interested
in the antagonists and invited the participation of our 1aboratories
in their scientific advisory board. Their fund raising is showing
that may be usefu1 for us
sufficient promise for me to suggestNew
York.
in
when
next
are
meet
you
again,
to

it

.

y
.

“1.-..

.7";

Hou1d you ca11 me

-_

;

-~.-.v.-;v.

,.4'

My

before your next

trip East?

best regards.

nu,.-q-;u-y:p,¢«,rapw

Sincere1y yours,

57

Jul-"ha

ﬁrm;

my“

Fink, M.D.
Professor of Psychiatry

Max

4'
.

Mszt

�</text>
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                    <text>.7, WW n.

»'I“&lt;-u

m. w rw-v, 1-H

,_.,

Y«r;4r4u ".‘B"VFWI«V21|"1

an”, ..-W~,,~-»4,yn“’12“m»“.

‘

u—.v~:—.-~

a

mug-'—

&lt;..,,w

.

v,r.~.,.rr,m. n...“

w...”

“ﬂ‘wﬂw

“‘7,“

“w

—

N'wu‘

-y

l‘Ml."Y

January 27, 1971

\-'”‘.'—‘rurwlwr

“my

w.

.

,
7
4w

T—y

a
h"

.m-

ww

”WM".

mmkﬂwnwﬂ‘t'vl'v‘mmv'ﬂ‘."

wmwvr

Dr. C11fford Joseph
Department of Medica1 Research

Hoffmann-LaRoche, Inc.
New Jersey 07110

Nut1ey,

Dear Dr. Joseph:
I have received the 11terature survey of the effects of 1evoDona on s1eep and EEG. Mr. Ryby presented me with at 1east six

re1evant c1tations that were very usefu1.

our

As
own

soon as I have an acceptab1e protoco1

quant1tat1ve study.

Many

thanks!

1

W111

try to undertake

Sincere1y yours,

Fink, M.D.
Professor of Psychiatry

Max

MFtkt

cc:

Mr. Neissman

K.

_

v.—

, .v..,, .

V

7.,

�</text>
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                  <elementText elementTextId="103386">
                    <text>January 27,

1971

Dr. William Cooper

Sterling Winthrop Research Labs.
Rensselaer.

New

York

Dear Dr. Cooper:
We have been requested each year to submit summaries
on each of the new patients inducted on cyclazocine during

the year.
corrected

A

for each is enclosed as well as a
of the patients currently on cyclazocine.

summary

list

Thank you

for your cooperation.
Sincerely yours,

u

11'

an"

Fink. M.D.
Professor of Psychiatry

Max

”Ft-'mwwwjb-HW

MF:kt

enc.
:rn

,

�</text>
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                    <text>January 25, l97l
Dr. Ramon de la Fuente
President NCP~l97l
Insurgentes Sur l748~503
Mexico 20, D.F.
Dear Dr. de

la Fuente:

pleased to accept the invitation to participate in the
Correlates of Mental Illness", and propose as the
program
title of the presentation:
I am

“EEG

Ragchaactiue ﬂange, Benin Function
and Human Behavion
The

necessary form is enclosed, and a copy was sent to England.
It was also kind of you to send me the outline of the proposed

program.

The participants represent as active a group as I know, and
should make a fine session. Perhaps Dr. Joe of Warsaw.(now in
Canada, I believe) should also be considered as a panellist.

If

Dr. Bente cannot

Df

the participants I know, I would

attend,

I would recommend Dr. Helmchen of

the University of Berlin as a replacement.
or Dr. Oswald as the

multilingual.

If the

recommend

either

proceedings may be published, Dr. Matousek or Dr.

secretary for the session
arranging publication.

would be a capable

I look forward

to

an

interesting

and useful convocation.

Fink, M. D.
Professor of Psychiatry

Max

Itil

and experienced in

Sincerely yours,

Mszt

Dr. Roubicek

active chairman, both being sophisticated and

�</text>
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                    <text>TO:

I.

B. Schwartz

FROM:

M.

Fink,

DATE:

January 25, 1971

M.D.

are operating at a 21 bed capacity, although we have 25 beds
for a variety of reasons, chiefly monetary and space. The units
changed from a detoxification, revolving door facility to an extended
treatment facility many years ago. when 128 was reclassified as general
We

psychiatry,
and

we

remained on

15A

where:

(1) Staff ratios were low,
inpatients with the same staff.

and we had

(2) Space on 15A had been assigned to
the medical supervision of our patients.

to treat outpatients
2

laboratories for

(3) Once we were committed to an intensive, careful study
of opiate dependence we filled fewer beds to provide adequate medical
care and increased our CPU load. we now have lOG patients in continuous

aftercare. During hospitalization we detoxify, treat medical illnesses
(of which there are many) and induct on methadone, cyclazocine or naloxone.

MF:kt

�</text>
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                    <text>TO:

I.

B. Schwartz

FROM:

M.

Fink,

DATE:

January 25, 1971

M.D.

are operating at a 21 bed capacity, although we have 25 beds
for a variety of reasons, chiefly monetary and space. The units
changed from a detoxification, revolving door facility to an extended
treatment facility many years ago. when 128 was reclassified as general
We

psychiatry,
and

we

remained on

15A

where:

(1) Staff ratios were low,
inpatients with the same staff.

and we had

(2) Space on 15A had been assigned to
the medical supervision of our patients.

to treat outpatients
2

laboratories for

(3) Once we were committed to an intensive, careful study
of opiate dependence we filled fewer beds to provide adequate medical
care and increased our CPU load. we now have lOG patients in continuous

aftercare. During hospitalization we detoxify, treat medical illnesses
(of which there are many) and induct on methadone, cyclazocine or naloxone.

MF:kt

�</text>
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                  <elementText elementTextId="106093">
                    <text>January 25, 1971
Dr. Larry Stein

Laboratories

Wyeth

P. 0. Box 8299

Philadelphia. Pennsylvania

lQlOl

Dear Larry.
I very much enjoyed your formulation of a theory of
schizophrenia. While fanciful. it has the merit of some
experimental study.

0n re-reading Ben‘s summary of imipramine in schizophrenia
(pp. 278-279). my comment still stands: there is no convincing
clinical evidence that imipramine has antipsychotic pronerties.
and Remmen gt glé_- a poor clinical
Hexquotes your theory (1962)
vo ume.

Enclosed are some reprints

report

on

that

may

interest you. Pollack's

disorganization of schizophrenia

by imipramine; Kramer's

statement on combined imipramine - chlororomazine; our study of
chlorpromaline;(0uprocyclidine) in depression; and a report by
Itil on high dose fluphenazine. The more recent data on higher
dose fluphenazine can be obtained directly from him.
My

regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kt
ENC.

�</text>
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                    <text>To:

A. M. Freedman, M.D.

FROM:

Max

Fink.

DATE:

January 25, 1971

M.D.

Mandatory Consultations

SUBJECT:

I can

think of so few medical situations that require a mandatory

psychiatric consultation that I hesitate to list even these. Rather
than subscribe to such a limited list, I would suggest a concept of
recommended consultations in the following instances.

states, particularly post-partum.

(1)

Withdrawal and depressed

(2)

Addiction syndromes, as in

post-surgery or postutrauma.
where a

threat to life is seen.

barbiturates, alcohol

and

opiates.

requiring restraints.

(3)

Toxicomania

(4)

Recurrent surgery without adequate oathology; and other states

—

as "hypochondrtasis" or

any severe delirium

”hysteria”.

Whenever the secondary diagnosis is depressive illness.
schizophrenia or severe psychoneurosis, and these diagnoses may
reflect contributions to the primary iliness or to its management.
15)

MF:kt

�</text>
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                    <text>January 25, l97l
Dr. N. Khazan
Mt. Sinai Hospital
New

York,

New York

Dear Dr. Khazan:

It

was a

pleasure to

visit

your laboratory. and to find so many

believe we may be able to assist you
quantification problems. and support the development
of an EEG quantification facility. He envision four steps:
(l) quantification of the data of your immediate projects.
using a variety of techniques for analysis;
problems of

common

in solving your

a

(2)

EEG

interest.

We

analysis of the data of specific projects, to provide
own data analysis unit;

basis for the development of your

(3) a review of the commercially available equipment
configurations and computer programs for data analysis for your needs;
and,

(4) an application for support. and the development of computer
programs for an analytic system for your laboratory.
For quantification using our IBM 1800 system. you will need an
FM tape recorder compatible with either our 7 channel (l/Z inch tape)
Aopex $9-300 or 4~channel (1/4 inch tape) Hewlett Packard 3960A. Copies
of specifications are attached: note the head configurations, tape speeds
and IRIG FM center frequencies and band widths (at various speeds) if you
1.

elect

a machine of another manufacturer. (He are not pleased with the
300 and suggest you investigate Sangamo or Hewlett Packard for a 7
channel recorder). You will also need an oscillator, similar to H0 202C.

SP

reviewed your usual method of data collection, the samples would
rats, continuous (or piecewise continuous) and the epoch
sizes, arbitrary. For period analysis, we are able to provide epochs of
any size, continuously analyzed, with a statistical output for the changes
after an event (drug administration) from the “resting” samples. If the
sample length is sdfficiently long, we can analyze the experiment at twice
As we

be subdural from l~5

the recording speed. The cost for AoD conversion, period analysis,
paper and card output is sou/hour of computing time.
.r'

war-:rr

“mmwm_w

..

”.115

r

statistics.

�Dr. Khazan

January 25, l97l

~2¢

If the recording and processing of the data are systematic, we are also
able to apply the appropriate multivariate statistics. Our present model is
based on linear regressions, and computer time using the 360/40 is calculated
at SlOOIhour with some pro~processing time at SlO/hour.
As a basis for future
to process the data in
optimal method. He are able to
analysis; to use power spectral

applications and for a defined project. you
variety of ways, to assure yourself of the
vary band widths and epoch sizes for period
density analysis; or to vary the multivariate
statistical approach. You should be aware that we now ore-filter our data.
between the tape and the A-D converter. The frequencies of interest to you
in the rat may differ from the frequencies which have customarily enjoyed
our interest, and you may wish to replicate the analysis of some samples
11.

may wish

one

without

filtering

and

a

at special filter settings.

Such experiments can be undertaken under the same conditions as

(I).

11!. Based on this experience, it should be possible to define your
needs and to canvass the equipment/software markets for the best configuration.
If done today. you should consider the lam loop (and our software) and the
DEC PDP«l2 (software in Philadelphia, St. Louis).
we once considered Control
Data and Scientific (Xerox) Data.Systems). There are additional manufacturers
that may be considered. Each should be canvassed for l97l~72 bids. we could
define your needs as we anticipate them or as they unfold in (I)(II), and obtain
the bids for you. It is important to consider the need for software support
and we can provide estimates for these costs. as well as deliver the programs.

(I!) and (III), we are prepared to assist
for support; and, as “consultants". to
participate in the defense of the application and in the establishment of
the program, including the training of the personnel.

IV. Based on the data of (I)
you in applying to funding sources

—

'

For the program outlined in (I), (II). and (ill) above, the direct
consulting rates are $300/day or $50/hour. A program rate for (l) and (II)
can be set at slSOOIouarter or a specific estimate for a project. For (1V),
the program charge is $4,600.

Rather than a piecemeal approach. you may prefer an annual consulting
and we estimate $6.000 based on our View of your needs.

It will

regards .

be a pleasure to have the opportunity

‘nvl

to assist you.

Our

fee.

best

Sincerely yours.

'wjr'ﬁ'v'c‘rrgtw'twmvlﬂ"

Fink, H.D.
Professor of Psychiatry

Max

w—n-m.

1‘
w

“ma-«“1

A

MFrkt

enc:

Brochure SP 300
Brochure HP 3960
EEG

Profile Analysis~Progress Report l970

Computer/EEG l967

Donald

Shapiro, D.Sc.
Professor of siestatistics
M.

�</text>
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                    <text>January 25, l97l
Dr. Wllllam Abruzzl, M.D.

Sfudenf Personnel Dlvlslon
Sfudenf Healfh Cenfer
Stale Unlverslly College
New Palfz, New York l256|
Dear Dr. Abruzzl:
As you know,

There Is no sallsfacfory +herapy of oplafe

dependence, and prevenflon and educaflon remaln lhe prlnclpal
roufes lo success. Methadone subsflfuflon ls useful and legal,

provldlng

a

pollllcally saflsfacfory solullon.

In +he research Iaboraforles, a process of decondlflonlng
wlfh +he ald of narcoflc anfagonlsfs, as naloxone and cyclazoclne,
ls under sfudy, buf The procedures are no? yef avallable for general

cllnlcal frlal.

I
suggesf you wrlfe Dr. Dole af Rockefeller
has
complefed a responsible revlew and recommends
Unlverslfy.
In
repealed doses (every 4 hours); and naloxoee (IV,
nalorphlne
I
when
If becomes avallable (Naloxone, Endo Labs,
mg/4 hours)
Garden
L.I., N.Y.).

For heroln
He

0.0.,

ley,

If you are pIannlng Io vlslf fhe clfy, you may wlsh To vlsl+
our unIf and speak To my assoclales who are +rea+lng our narcollc
addlcfs In a varlefy of ways.
Slncerely yours,
Max

FInk,

M.D.

Professor of Psychlafry
MF:k+

�</text>
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                    <text>w

-

w... m. w.

'v.

.1

~--

-

-_r»

any

~

,,

w“

w

..

..,

w.

my.

.

1

.-r.s...m;,7n,u.~.-T , ......._..

January 25, 1971
Dr. Larry Stein

Wyeth Laboratories
P. O. Box 8299

Phi1ade1phia. Pennsy1vania 19101
Dear Larry,
I very much enjoyed your formu1ation

schi20phrenia.
experimentai study.

Hhi1e

it

fancifu1,

of

a

theory of

has the merit of some

of imipramine in schizophrenia
sti11 stands: there is no convincing
c1inica1 evidence that imipramine has antipsychotic properties.
He quotes your theory (1962) and Remmen et_gl;_- a poor c1inica1
On

re-reading Ban's

(pp. 278—279),

my comment

summary

vo1ume.

Enc1osed are some

reprints that

may

interest you. Po11ack's

disorganization of schizophrenia by imipramine; Kramer's
report
statement on combined imipramine - ch1orpromazine; our study of
ch1orpromaline;(0uprocyciidine) in depression; and a report by
Iti1 on high dose f1uphenazine. The more recent data on higher
dose f1uphenazine can be obtained direct1y from him.
on

.

,.

My

w.

regards.

w.

Sincere1y yours,

.

'ﬂ'v'ﬂ‘ﬂ“

:rart-vrm-A—w

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc.

~e-vm---p.-wq.

Fwy—v—

“wavy—Wm...—

�</text>
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                    <text>an..."

TO:

A. M. Freedman, M.D.

FROM:

Max

DATE:

January 25, l97l

.-..

A—r.vn.-.vn~—&lt;,w-.'.,.,-..r,

Fink,

M.D.

Mandatory Consultations

SUBJECT:

w-K
n

,-v~.-—.—‘—.lw-

.n'

.7:

~

think of so few medical situations that require a mandatory
psychiatric consultation that I hesitate to list even these. Rather
than subscribe to such a limited list, I would suggest a concept of
recommended consultations in the following instances.
I can

(1)

Withdrawal and depressed

post-surgery or postutrauma.
(2)

where a

(3)

states, particularly post-partum.

Addiction syndromes, as in

threat to life is seen.

barbiturates, alcohol

Toxicomania - any severe delirium

and

opiates,

requiring restraints.

(4) Recurrent surgery without adequate pathology; and other
as ”hypochondrlasis“ or ”hysteria".
[5) Whenever the secondary diagnosis is depressive illness,
schizophrenia or severe psychoneurosis, and these diagnoses may
reflect contributions to the primary illness or to its management.
MFtkt

states

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                    <text>Br. Chris Zarafonetio
University of Michigan
Ann Arbor, Michigan

January 24, 1971

Dear Chris,

It was a pleasure to read the many fine recommendations
for candidates Get the Oscar Hunter Memorial Award in Therapeutics.
My two sets of evaluations are enclosed.
As I found it difficult to select among
groups of candidates,
I scored them two ways: an approximate ranking within
groups, and then
averaged the number for each group. If the scores are to be summed
across raters, I would suggest that the better estimate of my ranking
is to be found in the number within the brackets.

I truer these are helpful.
Sincerely yours,
Max

Fink, v.9.

Professor of Psychiatry
mf/

�</text>
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                    <text>January 24, 1971
Dear Ali,

is lovely,

It

in St. Louis last week. Your home
in wishing you and Lynn all success

was good to see you

and Mattha

in your pregnancy.

joins

me

return I find that the araangements for our assumption
of responsibility for 160 bedd at the local state hospital, on Ward's
Island, have been completed and the takeeover will take place at the
end of the month.
On my

If there is a desire on your part to continue your work in
the big city, I would be pleased to recommend your appointment. Of
course, TL would fetst arrange for you to visit.
My

best to all.our friends.
Sincerely yours,
Max

Fink,

M.D.

P.S. I discussed this with Turan in Aspen and he encouraged

write.

me

to

�</text>
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              <elementText elementTextId="46633">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>.»

«a

.u 'r'hVK‘J'NV'ranIg‘ﬂu Mu»:-

,~

(wriv-rv‘mnm‘wv-

:... .-,-.,v,r.,»,w.n-r

,

”up,

_H.‘

1.,”

,7

,,

w,

.

..,

,.

V,

“a” r, .. _\

.

—. ,

V

&gt;

_

~

.

,

'7

_

u"..--

.H

.
w

w».

”We...

,¢._vmm‘.-u&lt;

u

s
E

l
f
r
s

January 23. 1971
Dear Charlie,

Enclosed are mv nominations for APPA membership. For many
of the nominees, a score of A or 5 weans approval; and ? disapproval.
The latter could only have been given in the case where an apolication

was

and I found no references

available

the senior author.

been

'4' if
Is

separately
mailing

a

it possible
from

list.
We

we

available.

were

to focus
thos without ?

I believe

very good.

It is probable that

citation list

which the candidate was
many '3' ratings would have

in

on

the nominees with citation

admitted Chester Pierce

last year;

he

is

lists
on the

missed you in Appen: the weather was superb; the meetings
Try to come next year.

See you next week.

As

ever,

�</text>
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                <text>Correspondence to: Shagass, Charles</text>
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              <elementText elementTextId="46642">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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              <elementText elementTextId="46643">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                <elementTextContainer>
                  <elementText elementTextId="103389">
                    <text>.»

«a

.u 'r'hVK‘J'NV'ranIg‘ﬂu Mu»:-

,~

(wriv-rv‘mnm‘wv-

:... .-,-.,v,r.,»,w.n-r

,

”up,

_H.‘

1.,”

,7

,,

w,

.

..,

,.

V,

“a” r, .. _\

.

—. ,

V

&gt;

_

~

.

,

'7

_

u"..--

.H

.
w

w».

”We...

,¢._vmm‘.-u&lt;

u

s
E

l
f
r
s

January 23. 1971
Dear Charlie,

Enclosed are mv nominations for APPA membership. For many
of the nominees, a score of A or 5 weans approval; and ? disapproval.
The latter could only have been given in the case where an apolication

was

and I found no references

available

the senior author.

been

'4' if
Is

separately
mailing

a

it possible
from

list.
We

we

available.

were

to focus
thos without ?

I believe

very good.

It is probable that

citation list

which the candidate was
many '3' ratings would have

in

on

the nominees with citation

admitted Chester Pierce

last year;

he

is

lists
on the

missed you in Appen: the weather was superb; the meetings
Try to come next year.

See you next week.

As

ever,

�</text>
                  </elementText>
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              </element>
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        </elementSetContainer>
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          <elementContainer>
            <element elementId="50">
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                    <text>‘4

'
£77!-

K.

January 20, l97l
Dr. Allen P. Borger
Chas. Pflzer &amp; Co.
Grofon, Connecflcu?
Dear Allen,

are conflnulng our Navane - Thlorldazlne sfudy and requesl
an addlflonal supply of:
We

IOOO

capsules Navane

2 mg

Label enclosed.

Slncerely yours,

Max

Flnk,

M.D.

Professor of Psychlafry
MF:kT

�</text>
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y-x-vrrv-rwnmwvrw

rm“

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an:

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cue-w."

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z

E

E

January 15, 1971

Peter J. Geerlings
Psychiatrische Universiteiskliniek
Wilhelmina Gasthuis
Amsterdam, The Netherlands
Dr.

g

E

g

Dear Dr. Geerlings,

It

was a

pleasure to have you

liberty of writing to

visit

Dr. Cohen about our

and I have taken the

interest in chronic

cannabis use. I am grateful for your suggestions and look
forward to calling you in Amsterdam in late March.

Incidentally, the next post brought an invitation from
vonPraag to attend the meeting of the biological research group
in September, and I was pleased to accept.
I trust your tour of the U.S. gave
diversity and majesty of our nation.
My

you a chance to see the

best regards.
Sincerely yours,
Fink, M.D.
Profesaof of Psychiatry

Max

MF:kt

war."

_..“:

�</text>
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January 15, 1971

-...—.....W...-.v

Editor

JAMA
.,.—w.-w-.v—ma.wuw~m—

535 N. Dearborn Ave.

Chicago,

Dear

Illinois

60610

Sir:
I

was

interested in the report in International

Comments

of November 23 (213: 1572) that confiscated cannabis in Germany
was equivalent to 2,278,170 kg in 1969. On inquiry, you kindly
sent me a copy of the original report, "Informationsdienst der
Bayerischen Landesarztekammer in Munchen” of August 21, 1970.
In reading page 2, I now understand the source of the data,
but suggest that in translation an error has been made. The
report reads:
Cannabis

1968

1969

380,924 kg

2

278,170 kg

It is the European practice to use the comma in decimal numbers
where we use the period. I would read the amounts as 380.924
and 2,278.17 kilograms, equivalent to 838 and 5,012 pounds. The
other numbers are more reasonable, i.e., 587,479 grams, read
as 587.479 grams equivalent to 0.59 kilograms, or about a pound.
A recent
report of U.S. seizures is enclosed to put the issues
in perspective.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

E

MFrkt

vmawwm

�</text>
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January 15, 1971
Dr. Jonathan 0. Cole

Superintendent

Boston State Hospital
Boston, Massachusetts 02124
Dear Jon,

It

pleasure meeting with the editors of Semina&amp;6.£n
I was most heartened
It was an impressive group, and do
and
enthusiasm.
I
not recall being
discussion
frank
by their
and
perhaps I under—
a
for
such
talented
many
a
group
among
year,
excitement
in Boston.
the
for
of
the
some
stand
reason
part
was a

Psychiazng.

to the project, I understand I should proceed to invite
reports reflecting the recent research findings in ECT, focussed
on the topics listed in the attached memo. we should set a target
date for manuscripts of August 1, for you by November 1, with
approximately 200 pages of typencript.
As

In addition to the research topics,

we

should

solicit

a

clinical section, preferably in Q. and A. form to satisfy the
more directly practical questions. This should encompass about
15-20% the text. There may also be a theoretic overview to review
the theories of the mode of action of ECT and suggestions as to
research needs.
and

Please review the attached

suhjects.
Some

list

of potential contributors

technical questions.
(1)

Is there a budget for a fee for contributors?

(2) We have an MT~8T and if we retype the texts, the
made available. For some publishers this is a distinct
be
tapes may

saving. Is
technique?

it

(3)

for

Grune and

I! there

Stratton,

a budget

and

shall

we

plan on this

for secretarial (editing) expenses?

�~2~

Dr. Cole

January 15, 1971

While I understand the copyright will accrue to the
and
the probability of royalties slim for the journal
publisher,
do
believe we should negotiate an understanding regarding
edition, I
royalties in the event the issue is highly successful and in reissued in soft—cover and in hard cover ~ particularly the latter.
I am sure you already have a standard agreement and this should
(A)

be reviewed.

What happened

in

Dartmouth?

In the rush I forgot to ask.

If you're not interested, I an.
Expenses for the trip on Monday were air fare ($52.00) and
ground ($14.25) for a total of $66.25.
Thanks again for the invitation to contribute to Seminars.
Sincerely yoora.
Fink, M.D.
Professor of Psychiatry

Max

Hszt

�</text>
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                    <text>;-.»~-vxv,....-.u.mr-m- i'P-‘WWWEu-«v-‘ETnWatw-v.,— 1n- Kw.
.

January

»

warm. as!

15 , 1971

Dr. Rianar

Food and Drug Rcacarch LaboratorieHhurica Arena. at 58th Street
Maapcth. Raw York 11378

Dear Dr. Eisner:
As Dr. Zak: has explained that our cdniniatratora requaat
a aorc torual contract than our letter of agrccncuc, to encompasa
in our relationship tho sanc autoguarda that our contract with
NACC provides for us, I «culd appreciate your signing the cnclosad
original and ouc copy, return both to us. and we w111 return a
singed coyy for your files.

Good

luck in the project.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Mix

�</text>
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                    <text>‘-l\‘l",v'-'

--»~,»-—~

r&lt;

WV

m-wmm-y

..

«aw-n-mu—s-a—vwwmrwnq-nw

rpwwmewwmw

{zinlm x
-

-

.u v

---»

v

--

.

-

v»:

r-

.7.»

,

‘ww-Vrvmn ”wronw

x-rx.

,. yaw-n

mam"- «nan w»,

Jnunary 15, 1971

“to

Co

”gala
State Narcotic Addiction

saw York

Control Commission
1855 Broadway
New York, New York 10023
Dear Mr. Dryadalc:

Enclosed are the renewal application. for tho study programs
in narcotic addiction, directed toward the dovelopuont of untagoniats
and toward on npprovcd undorstanding of the addiction process, from
this Collegc for 1971*72.
no or. gratoful for the discussions that an have hold with your
offico, particularly Milo Scott. in presenting this program.
Thank you

for your cooperation.
Sincercly yours,
Fink, M.D.
Professor of Psychiatry

Mix
W21“:

ham

3-

~

ww—

�</text>
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                    <text>F

,wv-

‘liw‘m ~—v—*m‘&lt;wxw ‘m .

o.

own-'17

‘

‘

,m

‘

.‘

mar?

‘59,,

mun

’r-vnruwx'

,.

r.

.
A

_‘_V

.,

"www.mw"

~v—w.-w,._u..m

m,m.,,_V..."_."—Ww

-w.-..~.~2,.

January 15. 1971

‘rﬂwm-r~w-\qr

Dr. Allen P. Berger
Chas. Pfizer &amp; Co.
Groton, Connecticut

E

Dear Allen,

Enclosed are copies of the anxiety rating scales for

ouch of the

subjects in the

Simoon thiothixcne open‘study.

I trust those are helpful.
wanna-unau-

Sincerely yours,
nrwmm

Fink, M.D.
Professor of Psychiatry

or

Max

"mun-war

I.“-lvwx-ukw

MF:kt

cnc .

V

-,w-—

,

".mWWM,

r-,--

«aw-u... )l'lrfhm’m_

�</text>
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                    <text>.

.

-“n wuss—“mpg..-

“n

Irru n

(7W

‘rraw-

.ﬁw v‘Il‘ ovum—u:

“MW-r

-

:w r,..,.-u--.

r: a «‘ixﬂm“.m'*w-WVF:V*P w I‘W'wlrw wmmwmvruns-s- )Fr-l'iw.n:'.' 'n'rnv—vrvmv-r— "Wm-A-

January 14, 1971
Dr. Hugh Freeman

Hospital
Salford M68HD, England

Hope

Dear Dr. Freeman:

It was a pleasure to have you visit our laboratory. Concurrently
received the proofs of the contribution to Shagass' book, and I
The citation (#13) to
am enclosing a copy of that galley proof.
T. Rothman is listed as:

we

Changing

Patterns of Psychiatric

Crown: New York, 1970

Care

It is

obvious that we hold a favorable opinion of the role of
formulation, and concur in your interest.
My

regards.
Sincerely yours,
Max

Fink,

M.D.

Professof of Psychiatry

MF:kt

enc. Galley (Kargel)

this

�</text>
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                  <elementText elementTextId="106107">
                    <text>January 14, 1971
Dr. William Tabor

A. H. Robins Co.

Richmond, Virginia
Dear

Bill,

vitae,

I

am

enclosing the statement of investigator form, curriculum

and a signed copy of the protocol for the hutaperazine
concentrate study. I believe we can fulfil the study goals with
the following amendments:
We

are not acquainted with the

this form, if necssary, but

would
changes in the EPRS and the C61.
The

protocol suggests

try to use
prefer to define the drug related
ROSIE. We can

all patients reclitethhe tablets first

and the concentrate on an immediate crossover. We should have a
comparison group and will elect to start some patients on the concentrate
with a crossover to the tablets.
15

I estimate an average dose of 50

patients,

we

will require

and an equal amount (6

butaperazine daily. For
butaperazine in tablet form
of the concentrate.

40 grams

liters)

mg

can begin some patients as soon as the supplies are
available, and will complete the study etethe optimal center
We

made

available this spring.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                  <elementText elementTextId="106108">
                    <text>January 14, 1971
‘Dr.

Jack Freund

A. H. Robins Co.

Richmond, Vtrginia
Dear Jack,

Enclosed is an answer from Paul Janssen to
about sulpiride. It is of little help.

Separately, I received

Stille

two

my

inquiry

reports about clozepine

from

is a pharmacological review and
indicates that clozapine has distinctive activity on a variety of
tests, interpreted by Stille as characteristic for antipsychotic
drugs. Angst gt 5;. is a clinical report in 126 patients with
diagnoses of acute schizophrenia and mania. The essay is presented
as a demonstration of the applicability of the collaborative,
computerized data collection and analysis system, so that much of
the text is devoted to technical features. But they are impressed
that clozapine has distinct antipsychotic activity with two important
features: no effect on muscle tone (i.e., no parkinsonism) and a
marked improvement of sleep disturbances. The separation of antipsychotic and parkinson features is considered sufficiently novei
as to become the basis of a test of the accepted theory that all
antipsychotic drugs must produce parkinsonism. Clozapine is
Dr. Hippius.

and Hippius

described as not having antidepressant or antimanic features.

If these data are verified, the compound should be active.
refer to a comparison with laevomepromazine and with thioridazine,
claiming that clozapine is at least as effective an antipsychotic as
these compounds; noting also that it has not been compared to the

They

piperazine phenothiazines.

An additional report not available to no
ArzneimitteZ-Fbrschung 19:496-498. 1969.

It sounds like an interesting compound
the reports of sulpride).
My

best.

is

Gross and Langner,

(better perhaps than

Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>~—

m pug-www—

W

.1

“rune—Mna—m

January 14, 1971
Dorado Beach Hotel
San Juan,

Puerto Rico
Gentlemen:

We are planning a 3~day scientific conference for
October/November 1971, for 40 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. we have not yet specified
the specific date, and I am writing to inquire as to the
availability of accommodations, and the costs, including

conference

facilities.

are the probable weather conditions in the second
October?
of
half
What
Many

thanks.
Sincerely yours,
Max

Fink,

M.D.

Executive Director

kt

�</text>
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Arizona Biltmore
Phoenix,
Arizona
Gentlemen:
We

mum-1n

va-mvv‘

~W.«mm-w

conference

.r

man].-

are planning a

3—day

scientific conference for

October/November 1971, for 40 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. we have not yet specified
the specific date, and I am writing to inquire as to the
availability of accommodations, and the costs, including

facilities.

What

are the probable weather conditions in the second

Many

thanks.

half of October?

W".

~"3W1-v

..

Sincerely yours,

my.

V

raw..."

r—una-v

—

Fink, M.D.
Executive Director

w—

Max

-m—um.u....w--.v,y,...

.m

.

9'
,___,

“Awe-w

A

;
.v

-mu—x;w~:—-uw—nmn,.~—rw

w-

kt

�</text>
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Tower Isle Hotel
Ocho Rios,

Jamaica

Gentlemen:
We

are planning a

3—day

scientific conference for

October/November 1971, for 40 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. we have not yet specified
the specific date, and I am writing to inquire as to the
availability of accommodations, and the costs, including

conference

facilities.

What

are the probable weather conditions in the second

Many

thanks.

half of October?

Sincerely yours,
Max

Fink, H.D.

Executive Director

kt

�</text>
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E

r
F

January 14, 1971
Bay Roc Hotel

Montego Bay,

Jamaica

Gentlemen:

are planning a 3*day scientific conference for
October/November 1971, for 40 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. we have not yet specified
the specific date, and I am writing to inquire as to the
We

availability of accommodations,
conference

facilities.

and

the costs, including

What

are the probable weather conditions in the second

Many

thanks.

half of October?

Sincerely yours,
Max

Fink,

M.D.

Executive Director

kt

�</text>
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——--w-.

,

wwmmww—wwmeurwum

i
g
'5,

r
E

é

January 14, 1971

E

Mauna Kea Hotel

Hamenala,
Hawaii

Gentlemen:
We are planning a 3-day scientific conference for
October/November 1971, for A0 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. We have not yet specified
the specific date, and I am writing to inquire as to the
availability of accommodations, and the costs, including

conference

facilities.

What

are the probable weather conditions in the second

Many

thanks.

half of October?

Sincerely yours,
Max

Fink,

M.D.

Executive Director

kt

7

Juan-J1

,

�</text>
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a

«sma- WW»WXT

,

.

tram .v

January 14, 1971

Castle Harbor Hotel

Bermuda

Gentlemen:
We

are planning a 3-day scientific conference for

October/November 1971, for 40 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. We have not yet specified
the specific date, and I am writing to inquire as to the
availability of accommodations, and the costs, including

conference

facilities.

What

are the probable weather conditions in the second

Many

thanks.

half of October?

Sincerely yours,
Fink, M.D.
Executive Director

Max
run-num—

kt

:mwm—

ﬁn-

�</text>
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January 14, 1971
"ﬂaw”...w.”

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mwv.

Dr. Arnold J. Singer
Chairman of the Board
Reed and Carnrick

Kanilworth,

Jersey 07033

New

n.

w...

v

Door Dr. Singer:

"WW—“W..."

The

V.__m,.._(v

title

your secrctary,

of our proposed presentation, as phoned to

is:

,—

WWW

MARIJUANA. EEG

W".

www.mwm.

.

AND BEHAVIOR

Jan Volavka, M.D., Rhea Dornbush, Ph.D., Stanley Feldatein, Yh.D..
Mix

..._....._...,-,..

Fink,

M.D. and

Alfred

%.

$reedman, M.D.

NW...”

Thank you

for the opportunity to participate.
Sincerely yours.

,rﬁvy...“n.,_v__“angst"..w.

m,

"ox Fink, H.D.

w...

.

Professor of Psychiatry

”4..."...

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                    <text>v

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January 14, 1971

‘avwrw;plrw“v&gt;r’awm,‘~—Vm

Dr. John A. Scigliano

.
w

Executive Secretary
Psychotomimetic Agents
Advisory Committee
Center fro Studies of Narcotic and
FDAwNIMH

Drug Abuse

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, ﬂaryland 20015

Dear John,
A

is A Grams. 0f the original 3 Grams
(ll~4*69) we used one ampule in pilot trials last coring, and a second
ampule this November~Dccember. We have one ampule (l Gm) left and
3 ampules of the batch of 7-10-70.
We will use one additional ampule
in pilot trials these next few weeks.
Our

&lt;-&lt;

raw-"mm...

.W'rr-‘c-"w-ﬂwv:

warm-w

MED

For our proposed study we wish to assay 20 subjects at each of
doses, for a direct use of 1400 mg THC. Since we have a 10-15%
dropout rate (inco'plete trials) we anticipate the need for 1600 mg
THC. Hence, our request for 10 additional ampules, to complete tho
study and provide 3 ampules for additional trials and/or errors in use.

Sincerely yours,
Max

Fink , Nun .

Professor of Psychiatry

l...

'q

present balance of

3

—

—r-_~‘1-4v-',

progress report of the recently completed study is enclosed.

MF:kt

�</text>
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                    <text>——....w~w.m.,.—v,.—

..,__....-

mrvm.._mm.w~._...u

January 14, 1971
Dr. Monique Brande

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

Dear Mbnique,

are continuing our studies of cannabis under HIMH~18172.
recent summary indicated that the absorption of active principle
via smoking is so rapid that many effects are maximal during the
20 minute smoking (2 cigarettes, 0.75 Gm, NINE marijuana). To
permit a shorter administration time (2 minutes) we have found it
useful to make up a small cigarette with sufficient extract (192 THC)
equivalent to 22.5 mg THC. This delivery system is effective and we
wish to undertake our next trials with this formulation.
We

Our

study, in male volunteers, 21 years of age or older (mean I 23)
is a single dose study, 7.5 mg or 22.5 mg THC equivalence. Subjects
are kept in the laboratory 4~6 hours. EEG and psychological tests are
Our

done.

have

ampules (SSC-61278 {RTI 1121~21A]) on hand. To complete
the pilot trials and a definitive study in 20 subjects at each dose will
require an additional 10 Grams of 17.1% THC, or the equivalent of 1500 mg
We

w

2

THC.

'

m-

I

rum—v

-':'.v

were.

do

appreciate your assistance.

Many

thanks.

Sincerely yours,

me

u—s—r-

-

rw-J'm"

Fink, M.D.
Professor of Psychiatry

Max

n-ww

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yr.

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Mrzkt

�</text>
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-' “M‘V‘rmw

1'

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1

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January 14, 1971
Miss Sherrye Henry
WCBS«TV

51 West 52nd

New

Street

York, New York 10019

Dear Miss Henry:
Thank you for the opportunity to read your editorial
”Amphetamines for Children“. The evidence for the successful

use of central stimulants in hyperactive children is clear,
and, as you stated, often appears magical in reducing hyper—

activity so the child, his classmates, his teacher and family
are delighted. Fortunately, tolerance does not develop and
treatment can be continued as long as necessary.
is not unusual and no
prolonged use has been defined.

The metabolism of amphetamines

complications to

its

It is a truism that no chemical which is given to man is
absolutely safe, and in each instance the use of a medication
must be balanced by the potential gains and the potential risks.
In this use of amphetamines, the gains are obvious: the defined
risks non-existant. There is no evidence that the use of stimulants
in childhood leads to abuse in adolescence. There is clear evidence
that hyperactive children, if untreated, are disruptive; fail to
learn, are stigmatized and may suffer prolonged handicaps.
I would, of course, concur in your suggestion that medication
for this illness be prescribed by trained and experienced professionals.
But I would suggest that your emotional response to the problem colored

the editorial unnecessarily and to its detriment. The last two
sentences are emotional outbursts, not in keeping with the leadership
and dignity of WCBS. In the text, the selection of such negative,
emotional words set a tone that is unfortunate: "jazz adults up",
"black magic”, ”drugged”, ”drugging him to submission".
—

wrap-

�Miss Henry

January 14, 1971

—2—

While I agree with the central message, that treatment should
be used sparingly where required and under professional supervision
I think the tone, emotional attitude, absence of facts demeaned the
not clear that a reply would serve a constructive
message. It
the community expresses considerable anxiety about
unless
purpose,

it

the message.
Again,

my

thanks for the opportunity to consider

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

NF :kt

this issue.

—

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                    <text>F“._

71‘”.

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,

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M

Point, Pennsylvania 19686

Our study of £~alpha~acetylmethadol is proceeding well.
have found, however, that the dose necessary to maintain
therapy is 120~180 mg/week in 3 divided doses. To accomplish
our mission at this dosage, wc envision the need for an

additional supply, up to 70 grams more than our present amount.
If supplies are available, I am writing to request an additional

100 grams of £~alpha~acetylmethadol.

I narcotic

requisition is enclosed.

for your cooperation.

Thank you, once again,

Sincerely yours,
Fink, 1.4.13.
Professor of Psychiatry

Max

MF:kt

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pm;

We

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Dear Clyde,

';

E

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Dr. S. Clyde Strickland
March Sharp &amp; Dohme

§

'

,~.. .mvg'l‘rvvv

January 14, 1971

E

E

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                    <text>i!

i ai

’“

1' "n ‘r ' 1-,- '13!‘.""W‘m&gt;~

_:_‘,

w-

”

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W

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.

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mw-_——~—...w.———.

yr"-

w

v‘omrunv

‘WrwwI—II-uvﬁn-v—V

January 15, 1971

-n.,ww&lt;_,_...,

Dr. S. Clyde Strickland
Merck Sharp &amp; Dohno
West Point. Pennsylvania 19486

Dear'Clyde,
havo decided to continue our studies of penicillaminc
(Cupriminc) in schizophrenia, and I am writing to request placebo
We

to contrast
Cuprinine. To provide an adequate control we wish
condition.
"no
treatment"
with
a
Cuprinine
of
the effects

If available,

Cuprimine.
Many

we

would appreciate 5000

tablets placebo

thanks.
Sincerely yours,

.w

,
"W...

1.7,,

.,
m,

w

Fink, M.D.
Professor of Psychiatry

w

Max

wanna—our"

ya:—

r
“n
er

HF:kt

r. .

,

�</text>
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                    <text>w

.u -"\v“‘~av WM»1¥F'W‘M-kw‘~7'v"v

w

.a

ivxwa-www ~17“

.

p-wy-wwum

Maw-”Vi!7.

January 14, 1971

Noahpitz“ ‘za

Mr. Joe

Hillcrest Childrens Center
1325 W. Street, N.W.
Washington, D.C. 20009
Dear Joe,
many

felt

It

was an unusual pleasure to meet once again, after
years. Mel and Blanche have spoken so often of you,
the gap in time was momentary.
as

if

these

that I

We have had little opportunity to apply our ideas to the study
of childhood disorders. The observations that stimulant drugs improve
the behavior of hyperactive children provides the basis for a
speculation in these children that is testable.

(1) The stimulants used, dextroamphetamine and
methylphenidate, alter brain function in a way that is reflected
in the EEG as increased fast activity, increased Inriability of
frequencies and decreased amplitudes.
(2) Quring childhood and adolescence, systematic
”developmental" changes in brain function occur, and these are
reflected in the EEG as progressive amplitude decrease, increased
regularity of rhythms (decreased variability) and increasing faster
frequencies, from the usual 4~6 cps of the young child to 6~8 cps
of the pre~adolescent to 9—11 cps of the adult.

it be that a characteristic of hyperactive
record more immature than their age, and both
successful treatment, a change is induced toward maturation (and
in unsuccessful treatment, the change fails to occur)?
(3)

children is

to

an

Could
EEG

enclosed summary of our
are enclosed.

The
ECT
My

EEG

theory and an earlier application

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

MF:kt

�</text>
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"

'u‘n

'

.

,

.1

4.,

‘W-‘“

w-vmo waswmrw—WWW
)2

-

'1‘.’

January 14, 1971

War...“

60th

Dr- K.
Koxhor 11
Amsterdam

Dear Dr. Cohen:

Dr. Peter Geerlings visited on this wank and in charing the
descriptions of our programs in substance abuse, we found much in
common including an interest in the long term effects of cannabis
(hashiah). When I doacribcd a project we are carrying out jointly
with the University of Athena, he told no of the presence and
possible availability for study of chronic hashish users in
Amsterdam, and of your studies. Our project is to assess the psycho»

logical

and nourophysiological status of chronic hashish users,
1965-48 and to be rc-oxamined by us this

identified originally in
summer.

It may be particularly useful to carry out parallel studios
in another population. Is thero a population of chronic hashiah
users who can be idcntificd, and who might cOOperate in acne
would you with to estimate any characteristics
(age, duration and amount of use?)? would it be of interest to
you to discuss such a study?

examinations?

I plan to be in Amsterdam in late March and could arrange to
meet to discuss the project in Athens, and any comparison in
Amsterdam.

in

Dr. Gearlingc sends his regards:

March.

he

indicated he
‘

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszt
cc: P.J. Gocrlings

would

return

�</text>
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                    <text>a
I

w, mm. 7"

&gt;‘W‘YJVWK’

Tww‘;-

..

.

-

a,

.

m“—

..

7

.

»

,

,

_

,

.

—"v

--

”um-an

,

.

w: xn'-lw1—.Ivvw-rcrva'h'lz'V'l'lV».mHIi-m"~~«.r. Av-‘vz-u’vsnwwma'«'ﬁ"u

January 14, 1971
TIAA/CREF

730 Third Avenue
York City 1ﬂ017

Ref:

New

A—195755«2

P—11é771-4

Gentlemen:

I should like to enquire as to the availablitgy of certain
options under the two policies cited above.
Can

will

I change the retirement date to age

55 (1978)?

If so, assuming continuation of present payments,

be the monthly payment on a 10-year

what

certain contract option

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
39

Arleigh

Great Neck,

Road
New York

11021

?

�</text>
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won-yumwm

."tq'c'o

January 1A, 1971
Dr. William Cooper
Winthrop Research
chssalaer, New York

Sterling

Institute

Dear Dr. Cooper:

are interested in continuing our studies of cyclazocine.
present we have 52 patients on continuous treatment and are
inducting new ones at a rate of 1~3 each week.
We

At

we have recently had some crises about the supply of medication
and I am writing to request a continuation of our present arrangement,
$42;9 a monthly shipment about the first day of each month with an

increase to

300

bottles, addressed to:

Dr. Arthur Zaks
Department of Psychiatry,

Metropolitan Hospital

Room 15A9

1901 First Avenue
York, New York 10028

New

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc:

A. Zak:

�</text>
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                  <elementText elementTextId="106122">
                    <text>"' «'"v‘w

'

-

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.,.._,.w.,_.;.,,¢ ”v.7. «m.

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,.

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.,

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,._».,,.

"my

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VWWHM, r,“

, _.,

January 11, 1971
Dr. Donald F. Klein

Hillside Hospital
75—59 263rd Street

Glen Oaks, New York
Dear Don,
Thank you for the descriptions of your-evaluation program
and the 1967 annual report. I will kepp your request for personnel
in mind, and bring it to the attention of our residents.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>w;

v—.—

n’
"um-m, -—m._~...
1

”yum.

,4

... ..

um. «mnmgx‘WSJVw‘lJrh~H1-‘
.

,

.

-

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,
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7

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,

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-mm. "
&gt;

4

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mm“

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w-v-

'-"

""“""-“‘~“

January 11, 1971
Dr. Marion Finkel
Food and Drug Administration
18733 Walker's Choice Rd.
Gaithersburg, Maryland 20760
Dear Dr. Finkel:

the

An
FDA

announcement

in the "Blue Sheet" that your office at
new drug evaluation, and the

is reviewing guidelines for

knowledge

that

send to you, a

Dr. Dorothy Dobbs has left the FDA, prompts me to
letter sent to Dr. Dobbs on December 1.

"Some weeks ago I received an inquiry which raised my
concern. Would I be willing to undertake an EEG study of

anti~obesity agent since the PMA guidelines for evaluating
such agents includes the phrase: "Consideration may be given
to a small EEG sleep Study”? my question is whether the
restrictive work ”sleep” should be included.
an

I\.wr£"

“qua...”-

.

ur-vrv

..-,

m...

«4

-cmr~.u,

mmmww

At present, quantitative EEG studies of psychoactive drug;
effects have a firm foundation in techniques of EEG analysis,
in the classification of drugs, and in the identification of
new psychoactive drugs. The literature is most reliable for
studies in alert subjects, and it is in such populations that
discriminations have been best made. Other data exists for
sleep, evoked response and contingent negative variation measures.
The literature of the latter twomeasures is
sparse.
For sleep, there is much data of a descriptive kind and of
generally limited value, since samples are small and studies are
few. The principal students, Oswald, Itil and Kales, are not
agreed as to drug specificity, or the relations of dose or
duration.

«

I'm-e

I'Kful

"um-wz'rk‘wmwmnw

war—W

w-

um

"WV-v

"a...“

In view of the possible value of EEG studies in clinical
psychopharnacology, may I urge that any FHA—FDA guidelines which
may recommend EEG studies, do so without a ”sleep" or "alert"
restriction? (Incidentally, such studies may also be useful
in bioavailability studies of all psychoactive drug classes,

and in classification of anti-psychotic, hallucinogen, stimulant,
anti-anxiety and saporific drug doses.)"

�Dr. H. Finkel

January 11, 1971

—2-

I am enclosing a reprint that summarizes the data to 1968,
and a more recent report. I would be grateful if you would accept
these comments and reports for your deleberations, and I thank you
for your consideration.

Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

MF:kpt

enc

o

�</text>
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            <elementTextContainer>
              <elementText elementTextId="46932">
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              <elementText elementTextId="46933">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="92017">
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  <item itemId="4694" public="1" featured="0">
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                    <text>.

January 11, 1971
Dr. James N. McClure,

Jr.

Eastern Missouri Psychiatric Society

Lindell Blvd.
St. Louis, Missouri
3839

63108

Dear Jim,

I am pleased to recommend Jovan Simeon for membership
in the Eastern Missouri Psychiatric Society. I have known
him since 1965. He is a sincere, thorough, conscientious,
knowledgeable psychiatrist and I recommend him highly.
Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
MF:kt

m

Wm'vvw‘:

my Tut‘s-u.-

�</text>
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            </elementTextContainer>
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            <elementTextContainer>
              <elementText elementTextId="46942">
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_

;

~.

.

.

.

~,——~w

,

\1-‘_v-'-"I.quw'-Word—Vanna”.mun—war"

January 11, 1971
Dr. Louis A. Wienckowski
Barlow Building - Room 10A23
5454 Wisconsin Avenue
Chely Chose, Maryland 20015
g

i
gr
F

Dear Lou,

Martin called to ask

"mm/v

APPA.

if

you were indeed a member of the

W,

3.

Of

my

"away.

-..,...._..

The

Association extended

ship invitation form, as requested.

,.

m.;m—.w-.«

-

course!

spring, to which your office responded
you

in

Glad to have you as a member, and
New York in February.

Incidentally, your dues are $10.00

Arnold Friedhoff.
my

best wishes for the

New

its invitation in

I look forward to seeing
and may be send to

Year!

Sincerely yours,
ﬂax Fink, M.D.

Secretary

HF:kt

the

by completing the member~

�</text>
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                    <text>January 12, 1971
Center Industrial Electronics, Inc.
15-17 East 16th Street

New

York, New York 10003

Gentlemen:
Kindly give bearer the items listed on the attached
xerox copy and charge our account. The approximate sum is
$50.00.

Sincerely yours,
Fink, M.D.
Executive Director
Max

MF:kt

�</text>
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                    <text>wr.”

v... — -ww-—\—- ‘wastuw w-F‘féE-wﬂwm'm
.-

w.“

..

wan-wu-

w.-

"‘4’“! .0.

z-m-y «aw-un-

January 11, 1971
Dr. Edgar Grunwaldt
Gcigy Pharmaceuticals
Ardsley, New York
Dear Ed,

have reviewed the two case records of the ketipramine~
iaipramine study and can resolve the apparent discrepancies.
We

Frieda Ehrenberg.

clinic.

Patient

was

unreliable in attending the

she received active medication and an appointment for March 10. She returned 1/2 box of medication on March 11,
indicating she had stepped medication earlier, estimated as 3/6.
She was referred for group therapy. Her follow~up laboratory test
on 3/17 was evaluated as on no active medication.
On March 3

Millie Mauer. On 2/17/69 she received ketipramine. She
had no medication from 2/10 to 2/17 due to a missed appointment
on 2/10. The laboratory tests were done before the new supply
was given. Since she had no medication for one week, test was
adjudged as on "no medication".
I trust this data is useful.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kt

«Jarv—

�</text>
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                    <text>Jr.

H. M. vanPraag

January 8, 1971

Psychiatric University Clinic
Division of Biological Psychiatry
Dostersingel 59
Groningen, Holland
Dear Dr. vanPraag:

a fortunate coincidence, your kind letter and invitation arrived this
I was entertaining your countryman, Dr. Geerlings, whom I found
delightful and who described your projected program. I would be pleased (and
am honored) to accept your invitation to discuss the issues of
opiate dependence,
particularly the problems of CNS effects of opiates, and our present treatment
models. With your permission, I would like to describe not only the experiments
with heroin and methadone, but also those with the antagonists, cyclazocine
and
naloxone.
By

morning as

In addition, we are actively involved in the evaluation of chronic cannabis
use. I should be pleased to participate in the cannabis discussions, particularly
the problems of evaluating chronic effects. we have recently received a contract
to study a group of chronic cannabis users and have had to make many compromises
as we faced the actual data collection.

I plan to be in Europe in March, and plan to visit Amsterdam probably
end of the month. Perhaps we can meet to discuss your
the
near
program
further.

Again,

;

my

happy 1971 and

thanks for your kind invitation,
for the success of the meeting.

and my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mfzkt

best wishes for a

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                    <text>January 8, 1971
Dr. John Schinel
£0 Granercy Park N.
New York. New York 10010
Dear Jack,
Enclosed is a revised version of "Toward a Rational Theory
of Behavior" for Career Directions. I have made the deletions
suggested by the editor, and almost all the changes in text which
I could. I hape this ”compromise" is satisfactory.

In re~reading the text, perhaps it may be useful to add the
citations as sources where the observations are reported in more

detail.

My

thanks for your cooperation.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kt

enc.
cc: Freed Scheel

0.3. Publications
299 Park Ave.

New

York, N.Y. 10017

�</text>
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                    <text>.4...‘..v_—..,..;..7. 37

i.

..- ...

.

H. V;

Tee. .‘gnr

q... wr&lt; .n‘ ,....,. a...vewmqwava—wuv«Fraser»

w’rmg" 'Jnviiw’ﬁvrrrz'w'wtr-‘ra

—-

»

N-t-Fyrn- «w , u

"r

.-

-1..;('. urn: .gnm'u—vw' w. .-

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urn-rm» w;

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,.,

January 8, 1971
Dr.

J.

Mandela

Associate Professor of Psychiatry
Department of Psychiatry
c/o V.A. Hospital
University and woodland Aves.
Philadelphia, Pennsylvania 1910&amp;
Dear Joe,

Enclosed are two copies of

contribution, "EEG and Clinical
Psychiatry", for the textbook. I have elected not to include a
number of EEG figures, since these are ably reproduced at greater
length in the citations. If, however, you believe the report may
be improved by examples, I will submit some representative figures.
There

is

a

my

single table. reproduced

from my 1969

report.

If

acceptable. I will write to the publisher for permission to reproduce.
your

I trust the report is useful,
invitation and your patience.

of this volume.

for
best wishes for the success

and I thank you once again
my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
one o

--

7-

-

�</text>
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                    <text>January 6, 1971
Dr. Arnold

J. Singer,

Chairman of the Board
Reed and Carnrick

Xenilworth,

ﬂew

Ph.D.

Jersey 07033

Dear Dr. Singer:

recent meeting of investigators interested in cannabis,
the proposed program next spring at the Academy of SciencesWewas
have
mentioned as a public presentation of the available data.
the
and
believe
two
studies,
recently completed the analyses of
data to be relevant and possibly sufficiently novel to be of interest.
At a

have established the EEG profile of cannabis as inhaled by
experienced users, in both acute single trials and in chronic (daily
x 22 days) use. Subjects smoked cigarettes containing the equivalent
of 7.5 mg or 22.5 mg THC. The data allows us to classify this compound
we

by
in relation to the EEC profile classification previously published
Of
and
special
others.
1969)
by
us (Ann. Rev. Pharmacol., 2; 241-258.
use ~ changes
interest are the changes in EEG profile with chronic
We
would
behavior.
propose the
which are associated with changes in
and
M.D.
Volavka, H.D.
Jan
Max
Fink,
title "EEC Profile of Cannabis", by
on immediate memory. and the
and
of marijuana. These data
dose
relation of the changes to task
Jones and
differ from those presented recently by Kiplinger,
of Cannabis on
”Effects
of
We
would propose the title
Tinklenberg.
M. Freedman, M.D.
and
Alfred
Ph.D.
Immediate Memory", by Rhea Dornbush,
Our second study

is of the effects

There are two additional issues that are of interest to us
that may be discussed at the conference. In oscwchronic trials, we
have noted a decrease in "tolerance" to cannabis, the subjects
developing dxpphoria after one week’s use. We are assessing the
possibility that smaller doses may be needed after repeated
exposure to achieve euphoria, and the recent reports of persistent
tissue levels of cannabinols may be an interesting contribution.

�.r—

.

v...“

-

.-

.

ww4.v"v.«

2.-

('~‘-'

(Aw—r m...»

Dr. Singer

.

.n-g

.7:¢'v.v-vv&gt;.

.-

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......,

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~2~

.N-..

in",

._

.

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4

new” .‘..

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.12.“.

.,

_

.

.

”1,.

January 4, 1971

have recently received a contract to study chronic cannabis
users in the Near East, to assess the evidence for persistent sociological,
social, and neurophysiological changes. In working through our tests
we

and sampling techniques, we became involved with the problems of

establishing adequate controls for the chronic drug user.
It may be useful to discuss these two
the problem of
"tolerance" on chronic use, and adequacy of issues,
population samples for
chronic trials, should the conference wish to review the immediate
research issues.
Our programs have been

Institute of mental Health

substantially supported by the National

if our
can
contribute to the success of the proposed public presentations.
my best wishes for the success of the conference.
and we would be pleased

Sincerely yours,
,.

,

Max

7””?va

_.

.:
«
ewe-nun

Fink, M.D.

Professor of Psychiatry

MF:kt

data

,

5

�</text>
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                    <text>January 4, 1971
Dr. C. Stefania

Eginition University Hospital

Vassilissis Sophias
Athens, Greece

74

Dear Costas,

Since we have finally received the agreements that make the
study in Athens feasible, we have examined the protocol and I am
now writing to propose a plan of study. As we reviewed the records
we became impressed with a number of issues: the population sample
and

its characterization,

for each subject of the total

tests

and records to be obtained
sample; the earlier records and their

the data,

and examination for comparisons; the problem of controls;
and
staffing — and all these before the actual detailed
a timetable
examinations of the definitive sample are undertaken. Also there are

availability

administrative problems, as to the funds, our visits to Athens,
housing and subsistence ~ but these will depend on how the project
some

unfolds.

Population sample.

we

are impressed that the description of

the total sample is most important to any conclusions that may be
drawn. we envision a sample of chronic hashish users, some of whom
have records from earlier studies. Since a small sample will be
studied intensively, it is advisable to provide as full a medical,
psychological and social picture of each subject, and of the total
sample from which our test sample is drawn.

view the sample and study in two phases ~ a global overview
and a detailed examination of the snail sample. Is it feasible to
do this sequentially with a few months hiatus or must we complete the
examination of each subject as we get him?
we

provide a basis for the data collection we have made up some
outlines of our suggestions of the data we would like to obtain for
every subject.
With regard to the psychological tests, we have tried to find
tests that have been validated in Greece but have been unable to do
so. Do you have any suggestions?
To

�Dr. Stefania

January 4, 1971

~2-

With regard to the neurological survey, it would be important
that this be a detailed survey. We believe we should make up an
examination outline that would include all the tests indicative of
organic brain disease and of peripheral neuropathy, similar to the
problems one would anticipate in patients with chronic alcoholism.
we are unclear whether the tests used in Athens are derived from the

German/English

literature or the French.

Could you supply us with

outline of the neurological examination in use in your hospital?
Early records. We are aware that Professor Miras has extensive
records of hashish users examined in the past. To what extent will
the present sample be derived from that earlier population? Are we
to make any effort to trace that earlier population, and what study,
an

if

any, should be focussed on

this earlier data?

Controls. The value of our study hinges on the population from
which we select our test subjects and on the adequacy of our controls.
If we so decide, shall we have the Opportunity to use siblings or

relatives of index cases or other as controls?
Timetable and staffing. My schedule is such as to preclude any
activity in Europe until early March. We would like to plan the various
steps of Phase I now, anticipating the period March 15 to May 15, as
the period for the initial sampling. we would use the data of that
sample to plan the second, detailed examinations, looking forward to
doing these studies during the period of June 1 - September 30.

For staffing we would propose that I join you in early March
for such planning as may be required. I will be accompanied by
either Dr. Feldstein or Dr. Dornbush who will provide for the

psychological aspects of the study.
During the

first

phase (interviewing the sample) one of our

staff will participate. we will ask you to provide the remainder
of the staff. Particularly we believe the social worker-administrator
and a

bilingual interviewer should be appointed

population and perhaps
provided by Dr. Miras.

make

the

initial lists

soon to identify the
or surveys from data

We have a special staffing need, that of a cultural anthropologist,
one who knows Greek history and culture, to assist us in characterizing
the sample. It would be ideal to have someone who has been trained in
both countries. We have not been able to find such here, and would ask
that you inquire at the University.

�use...

.,.&lt;...........‘W,,._

r,

‘_.m..r..-ryw—&lt;u.un:.-wf »

r$"’u.v~Vw—5v-'r.:‘a. ,.

Dr. Stefanie

I

am

”we“. ,4."

.

r

-,

n1;

»

‘

“er

~

; n» —&gt;vd-'I"&gt;'«smarn‘

.v

-3~

‘

es

.7”

-&lt;Iw.-»

»

.. m,"r;—w‘"xvn

'

*—-~

.,

-

.

w--

w--

January 4, 1971

enclosing our suggested outlines, timetable end proposed

staff arrangements. These working documents are suggestions to be
revised by you. The timetable is an optimistic one, dependent
completely on your staff work. Wbuld you revise this to make it
more realistic?
best regards
interesting venture.
My

and

best wishes for the success of this
Sincerely yours,
Mex

Fink,

M.D.

.Executive Director
Mrzkt

~'

A

�PROPOSED SCHEDULE

January-February

Planning, identification of population sample

Staff appointment
March 5~15

First

work sessions

in Athens

Pilot interviews
Checking Interview instruments
Reviewing the
March 304May 15

early

Miran data

Population Interviews: Goal 100 subjects.
Psychological, social medical data

May

15-30

Planning Second Sample
Data Analysis
Sample

June 1-Sept. 20

identification

Definitive

sample survey

neurological,
October

EEG,

Data evaluation

-

drug samples

�</text>
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                    <text>rrwmwawm-

37w...

-,.-, -

“—-\. ma

.

.prrre.‘

.

,gf
Mr.

Earl Ubell

51 West 52

New

Street

York City

’

’
_.

;;7;5¢f
"
é

T'

_

la:

jf’

:‘_,

"

*Jahuary 1, 1971

_

.7”~'

'ﬁﬁf‘

».--..1 f_s$

ﬂ

‘

Dear

Earl,

l
your

the local
series for
National Academy used excellent judgment in citing
excellence. I do hope there will be a chance to make this series
more generally available as one overview of the drug use problem.
There is one optimistic sign on the college scene, that drug use
may in fact be decreasing as this new wave of meditation sweeps
various campuses. My son tells me that drug use has fallen off at
his campus as more than 200 students are meditating.
Congratulations on the award for Drugs

A

to

——

Following your suggestion, I reached Joe Lelyveld of the
arranged for both Altman and Severe to call
about a presentation. Severo was also called by NACC's chairman,
Milton Luger, who was concerned that his commission's role in the
program had not been acknowledged.

new York Times, and he

...

.1..."

r...

,,_.,,,_,

Thanks again
newsworthy 1971 !

for your advice;

my

best wishes for a
Sincerely yours,
Max

Fink, M.D.

most

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                    <text>v-r‘I-v‘

guru-WW.“

_

,

February 26, 1971
Dr. Frederick Gibbs
1427 N.

Chicago,

Astor St.

Illinois

60610

Dear Dr. Gibbs:
Your recent

EEG, I:
editorial (Clinicalw

127)

asserts that

"cannabis indica produces no marked or consistent changes in the
EEG" md ". .. the changes they [psychotomimetic drugs] produce in
the electrical activity of the cortex are of the same minor order
as are produced by tobacco“. It is difficult to see how you can
arrive at such sweeping conclusions, based on the data printed.
The report by Deliyannakis et a1. finds large effects of
cannabis, in a few subjects, with equipment of limited frequency
response. They make no effort at quantification and we have no
idea about the sample size, stability over time, artefact control,
Despite the limitations of equipment and technique,
filtering, etc.
they report large changes, albeit not in every subject.

In numerous studies of the EEG effects of heroin, LSD, major
changes have been observed and related to drug dosage, pro-existing
EEG and clinical effects
(for examples, see Ann. Rev. Pharmacology,
9:241—258,1969; Neuropharnacology, 9:539,1970). Such studies
show that large EEG Changes are common, drug and dose related, and

interestingly related to the behavior of the subject.

Considering the major strides made in quantitative EEG, it does
neither the science of EEG nor clinical practice a service to make such
sweeping assertions as "Let's face it, disordered psychic function,
either spontaneous or drug induced, commonly does not correlate with
major abnormalities in the waking electroencephalogram".

�Dr. Gibbs

~2-

February 26, 1971

Years ago we looked at the moon and saw a fairly flat surface
with a few ridges. With better tools. it became obiious that the
ridges, mountains and valleys were substantial. How substantial was
recently demonstrated by the astronauts limited ability to climb a
small ridge. The sruface EEG is not a homogeneous, insensitive flat
serface, but a sensitive, ever-changing reflection of mood, memory,
and

alertness.

use them.

Our

tools

Particularly,

do decode differences already, were we to
were we to look carefully, with the tools

of the 1970': not those of the 1940’s.

Sincerely yours,
Max

Fink, “.0.

Professor of Psychiatry

MF:kt

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                    <text>February 26, 1971
A. M. Freedman, M.D.

TO:
FROM:

Max

Fink,

m.

Chapter in Textbook, Tranquillizers in Psychiatry

SUBJECT:

it

I have read the chapter (35.1) as you suggested, and find
quite good and up~to~date. It is easy to disagree with some opinions;
to suggest that the emphasis be changed, but any criticism would be
minor compared to the major areas of agreement.
be

80%

If you

wish

this rewritten,

very similar to Denber's

less chemical,

I can do

article,

more neuroPhysiological.

it.

The

result will

but the emphasis will be

are correct in assessing an absence of data on lithium
Kalinowsky's section on miscellaneous therapy is weak.

You

therapy.

My principal hesitation is the personal
conflict with Hy. Please assess the risks and
to the gains, and make your decision.
Mszt

one of coming
damage

into

in relation

�</text>
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                    <text>February 26, 1971
Dr. Fritz A. Freyhan
St. Vincent's Hospital
153 West 11th Street

New

Dear

York, New York 10011

Fritz,
Thank you

for the Opportunity to read the report

"An EEG

Loss During Alcoholic Intoxication" by Freeman,
Goodwin and Othmer. For the reasons described in the attached

Study of

Memory

critique, I find the report unacceptable for publication in its
present form. The subject is an important one, but the contribution
is too inconclusive to merit the space. I believe the authors have
better data ~ I hope they do, in any case ~ and that could be the
basis for an acceptable report.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
0116 o

�</text>
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                    <text>February 26, 1971
Hr. Emil

New York

J.

Drysdale

State Narcotic Addiction

Control Commission
Executive Park South
Albany, New York 12203
Dear Mr. Drysdale:

Enclosed is a copy of the most recent voucher, which
includes the expenditures to 1/31/71. One item needs explanation.
Consultant fees will rise to almost $60,000 as we have let the
,

contract with

Food and Drug Research and payment

is deferred.

Sincerely yours,
Max

Fink, MJ).

Professor of Psychiatry

MF:kt

�</text>
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                    <text>February 26, 1971

Secretariado Del

V

Mundial de

Congreso

Psiquiatria

Apartedo Postal 20—123/24

Mexico, D.F.

Gentlemen:
WCP

in

for

2

Enclosed

is our

Mexico City.

check

for $60.00 fOr

membership

in the

I wOuld also appreciate a reservation at the Camino
for arrival Sunday, Nohember 28 to December 4, 1971.

I have already accepted the invitation
symposium "EEG Correlates of Psychiatry."

Real

to participate inthhe

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1971

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.

February 25, 1971
M. Stone
Seminars in Psychiatry

Mrs. E.

591 Morton

Street

Boston, Massachusetts 02124
Dear Hrs. Stone,

I have read the

to respond.

comments on

the

ECT

issue

and would

(1)

Redundancies between Fink and [Schildkrnut] are

(2)

I agree that the relation between psychotherapy

resolved.

is a

like

and

much neglected issue. Unfortunately, I know of no one
who has made a serious contribution to this problem since the
in the 1950's.
reports by Abse, Kahn and my co-workers, Jaffe —
If you know of anyone who can contribute to this question, I would
HOT

all

be delighted to invite such a section. I could ask one of my
Hillside canworkers, Harold Escover or Joseph Jaffe to write such
a section, but I know that they have no recent data.

(3)

The

for Indoklon.

Q &amp;

ECT.

and

A,

if

not the clinical.

contribution will focus

(4)

My

(5)

There are no new data that

on these
we

theoretic issues.

have found on drugs and

I asked that the data be reviewed in the clinical section,
if not there, I will put in some questions in Q A.
&amp;

(6,!) I agree that these are critical questions. Date may
and memory section. If not, I'll try to get some

in clinical
answers in T &amp;

be

single clinical section is for ECT; there is another
special proglrms described will be covered in the

The

A.

�--r W~

--

a":

v wv

~w~w~—-.—v—v—-vm.

«my...

'I’l'w-RHV

Mrs. Stone

.

,,

,,._._..-,,,,..,..

w..."— .7»

.-_...., v

n _ ...__..

M,

—2~

,.,...,..,.._._...,

.

.. -v. -..

February 25, 1971

I heartily concur with the reviewer's last

comment.

In

thinking about the questions about psychotherapy, combinations
with drugs, overtreatmant, abuse of ECT, etc., I think we might
consider a section on ”needed studies" or the questions that
might be looked at critically. This is a section that could be written
by someone with tho various texts in hand, noting the omissions
and needs. I can think of two men who could do this well - Milt
Greenblatt and Jack Ewalt. May Ichavo your advice?
thanks for the fine comments. I find the project
most challenging and trust we can get a fine issue.
Again,

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc: E. Bartmann

�</text>
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                    <text>.-.

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February 25, 1971
.__,_

n
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Dr. Peter Crown
Mediache Paculteit Rotterdam
Dr. Moleuaterplein 50
Poetbus 1738

Rotterdam, Holland
Dear Dr. Crown,

.7-

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mat-9-

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m"

The

on clinical problems
of
our funds are in
sources

studies in the Division are focuased

clinical populations.
support of clinical treatment of in~pationta at Metropolitan Hospital
(studies of ECT: new drugs in anxiety, depression and schizophrenia);
the treatment of opiate dependent subjects (antagonists in opiate
dependence; methadone, heroin): and research programs in the clinical
pharmacology of cannabis, the quantitative assessment of EEG anoman
and the EEG effects of opiates.
and

The major

of operation can best be described as collaborative,
focussed research, designed by a project leader in association with
other participants. Projects are usually described in writing: critiqued:
and if approved by the Division, sent on for school approval. There
is a hierarchical structure in this Division and promotion is as rapid
as the studies and energy expended warrant.
Our method

You

should know that the Department Chairman

in biological

psychiatry and

is actively interested

is the principal investigator of the narcotic

antagonist and cannabis studies.

are integral to almost all our studies and these
Volavka and myself. In your initial assignment
Dr.
Jan
are supervised by
I would ask you to aasiat him in his projects. Right now his principal
work is the analysia of the ECT and methadone/heroin data. The
studies of marijuana effects on EEG and behavior are in the data collection
phase, and the next BOT/memory and chronic marijuana studies will begin
The EEG programs

data collection in March/April.

Our EEG work is concentrated on the ongoing
planning any averaged evoked potential studies.

signal;

we

are not

.\

um“, a...

�-W=_w-w»--«—~=-v.vw~‘-mI_meﬁ_-Hn.“.m—w‘s‘vmwvi—H«—‘H‘W17Z.Pw&gt;’n~w&lt;‘q._«—w“1r~__vvrrnw&gt;~w.1~“m‘r\'m‘~‘w‘“"'

mm

m-w..___m.v—m-.w._—w-w

Vi

u.

~.«

~—

Dr. Crown

..

..

r

w.... y...

7......“ -"-’~

Hl'vw'v-Vrv-c ”ml-t."

‘

February 25, 1971

~2~

Host of our space is used for laboratories and our office
facilities are very crowded. But we have learned to adapt for
there is a new facility with adequate space that was due for completion
the summer of 1970, and now should be available the winter 1971-72.

There are a reasonable number of research assistants. technicians,
computer console operators; and funds for equipment and supplies
are adequate. Travel funds are virtually noneexistent, except on

invitation, and these are fairly frequent. Secretarial aervices are
also restricted, so that most of us do our own typing (except for
final reports). Calculators, typewriters, computer time, library

facilities and copy facilities are freely available. Our teaching
commitments are minimal and the Ph.D. staff devote 992 of their time
to research.

associates will tell you, it is neither the best and far
from the worst of laboratories. Your "progress" will depend on your
energy and productivity on one hand, and on the rate which we meet
As my

our shortvterm goals.

work

I trust you will join us and udll find the same satisfaction in the
that we have found. If you have some more specific questions

about the EEG work I suggest you address them to Dr. Volavka. If
you have some questions about our organization or attitudes, you may
wish to write to Stanley Feldstein, Ph.D., Associate Professor, and
project leader in clinical cannabis studies; or Rhea Dornbush, Ph.D.,
Assistant Professor and a project leader in ECT/memory and cannabis

projects.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

wnanw—zma

w...”

_

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                    <text>February 25. 1971
Dr. Allen P. Borger
Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Allen.
EEG

Enclosed is a supplementary statement regarding the
effects of thiothixene 1n depressive outpatients.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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r

‘r—

«VP-um r'.‘ .—.~.vv««we W..,..,..—-mw

—-.—....mm_. .,... w...”

w.—»,.--u-u.»———-——w—v_.

,7, ..

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.

- .. ...

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w. '7

,

w,

,

February 25, 1971
Dr. Michael A. Taylor
9309 Murillo Avenue
Oakland, California 94605
Dear Mickey,

I have read your set of ambitious and moat
them aeriatim, I made some

Both Dick and

interesting proposals. In reading

notes and these are included with suggestions.
In

4), I believe

sum, (page

you could

set

up a study of

lactate now, for application to NIMH before June 1. I think
this is the most fundable of the projects. The need for funds
is not obvious to you now, but will become obvious by the end

of the year. I am enclosing an outline of an NINE application
and a copy of our ECT application to give you an idea, both of
an application and Dick's ECT project. I suggest you write up
the sections on Aim, Methods (subjects), Previous work done
(by others, by ?.I.), significance, references. I can write
description of facilities and the budget.

For the

rest

~

a

neuro~endocrine effects in schizophrenia,

you will receive notes and reports
from Dick or myself to keep you up~to~date, but there is no urgency

penicillamine, ECT~depression w
in these.

The relationship with Kirby State Hospital is agreed to, but
the final steps can only be taken when a budget is approved. The
present ”freeze” on appointments to the State should be lifted by
April 15 and I am confident Dick will be in Kirby by that date.

It was a pleasure to read the notes. Try your hand at a
grant application.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkpt
QBCB a

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                    <text>nﬂmw“wv.€wmmn

&lt;Wv a, nu.WW

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E

5

February 25, 1971
Daniel Blain, H.D.
2100 Clarkson Avenue

Philadelphia, Pennsylvania 19144
Dear Dan,

There is one member of the Association, Joseph Zubin, who
has been most intimately involved with the association for half
its lifetime. He has written the most recent history (1965) and
I have asked him to answer your inquiry.

affiliated with Hillside Hospital, and
of the dramatic impact that Israel Strauss played
in New York psychiatry between the two World Wars. While Hillside's
impact on American psychiatry may be considered modest, it had a
great influence on New York psychiatry. Historical notes can best
be obtained from Joseph S. A. Miller, the medical director to 1961.
came

For ten years I was

to

know

Also, many research institutes were established with much
enthusiasm and optimism as the way to cure schizophrenia during

the 1950's and 1960's. I was intimately involved in setting up
the Hissouri Institute In St. Louis (1962—66) and notes about
this history may serve as an example of this trend. But then
you could document the centers in Omaha, Galesburg, Iowa City,
New York, 335,, with as much profit.
Good

luck in the project.
Sincerely yours,
Max

Mszt

Fink,

M.D.

,.

-.

.

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                    <text>February 25, 1971
Dr. Joseph Zubin
722 West 168th Street
New York, New York 10032
Dear Joe,

enclosed letter from Dan Blain should be answered,
and I can think of one—one better qualified than you.
Would you answer this request?
and

The

A1

Many

thanks.
Sincerely yours,
Max

Mrzkt

cc:

A. H.

Freedman

C. Shogass

Fink,

M.D.

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                    <text>February 24, 1971
Mr. Nathan
NAPAN

Strauss

250 West 57th

New

York.

New

III,

President

Street

York 10019

Dear Hr. Straue:

It

was kind of you to send me the January

NAPAN

bulletin.

extent of the activities of the association is interesting
and you are to be commended for your interest in the difficult
field of addiction.

The

I noted with some nostalgia that Arthur Fatt is a member
of your board. I met Mr. Fatt years ago when I was Research
Director at Hillside and we were interested in funding a research
building. I am sure he will recall the meetings with Israel Strauss
and Herbert Beskind.
Perhaps this is an opportunity to suggest that the next
methadone conference may contribute even more if other bidlogical
modalities were discussed, particularly in answer to the question,
"After methadone, what next?"
Thank you again

for your interest in the

Academy meeting.

Sincerely yours,
Pink, 3.9.
Professor of Psychiatry

Max

Mszt

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                    <text>arr v-.~.--um._.—-u.~ nw—Wn'mm.— 1.,,,_..,,.__,

.,

a”, rumamwmw

,wrm.u...‘"1_m MW...” ,.,,.._.....~....,.
.

..

.

.

.__ -W. . “F‘WNV
_

,

cm

ﬂ W._‘.

February 23, 1971
Dr. E. F. Domino
Department of Pharmacology

Medical Science Building
University of Michigan Medical School

M6322

The
Ann

Arbor, Michigan 48104

Dear Ed,
.m..—qrw&lt;w

to receive your review of the biochemical
studies in ECT. It may be obstinacy, but the
possibilities in
primary problem is acetylcholine, not the cholinesterases. That the
leech muscle is insensitive is a severe barrier, and these studies
will then have to wait the refinement of methods. The studies and
theories of epinephrine, norepinephrine and serotonin in psychiatry
received their heavensent thrust from the chemical description of
means of measurement, not from a theoretic model. Hepefully, the
same will follow when a new method for ACH is develoPed.
We

v-cwnv—r,

l-—

r

were pleased
CSF

Many

"Nu...

thanks for your frank discussion.

Sincerely yours,

mmvynpwy

-

V-mw'rwa

a

Fink, H.D.
Professor of Psychiatry

Max

In:

.

7m-ml'vmrrw

:mstn'qu

vm“-m~wwwr

r
1::
aw:

"we

Mszt

�</text>
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.vn-v

.a—vr,»-.w»m

—‘v1w—W.

awn-w"

Mr. Paul Argeros
13945 N.E. 10th Avenue

North Miami, Florida 33161
Dear Mr. Argeros:

It

was

kind of you to write about our research program.

The drugs are still in experimental trial and are not
available outside our institution. For the meanwhile, we suggest
you continue with methadone. We are confident that as soon as our
treatments are approved for general use, they will be publicly
available in your community.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkt

�</text>
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February 23, 1971
Dr. E. F. Domino
Department of Pharmacology

Medical Science Building
University of Michigan Medical School

M6322

The
Ann

Arbor, Michigan 48104

Dear Ed,
We

were pleased

to receive your review of the biochemical

possibilities in CSF studies in ECT. It may be obstinacy, but the
primary problem is acetylcholine, not the cholinesterases. That the
leech muscle is insensitive is a severe barrier, and these studies
will then have to wait the refinement of methods. The studies and
theories of epinephrine, norepinephrine and serotonin in psychiatry
received their heavensent thrust from the chemical description of
means of measurement, not from a theoretic model. Hopefully, the
same will follow when a new method fer ACH is deveIOped.
Many

thanks for your frank discussion.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
A

A

vale...

n

.W

�</text>
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erIm.'lww'—~—-1h.

‘

,

i

t‘r‘."',—-I,wrv~

/‘V.~rrr

:5”:qu ,Was..wﬁ..

7...

~———-.~,. ”was...“ ".4

.Mruns n..." svw..., ... “urn—.1. ”mam. ...v -___[.- VM. .m. .. .W

February 23, 1971
Mr. Paul Argeros

13945 N.E. 10th Avenue
North Miami, Florida 53161
my

Dear Mr. Argeros:

It

was

kind of you to write about our research program.

still in experimental trial and are not
available outside our institution. For the meanwhile, we suggest
you continue with methadone. We are confident that as soon as our
treatments are approved for general use, they will be publicly
available in your community.
The drugs are

Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
«ran-n

Err-

,

MP:kt

_.

.,

,

_

�</text>
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                    <text>in?”

n.—

sz-aw

-

--

*lW-mvnrv‘ ’i-‘orarw~y.-w—._..mwv~w
Isa-um)...
v

,

W... IAﬁmyrxnn’m'wm'ndwﬁ‘wl-mv4wV1-‘V‘ﬁ

NVTWv'n-l'wu‘nr'vwm'vvrnw.

v m,w

-mww-m-«aur‘w—mqwngnm "w?" r—u-w

February 22, 1971
Dr. William Martin

National Institute of Mental Health
Lexington, Kentucky
Dear
v,

”.mpnwwma...

,1."

,..7..,.,.

Bill,

Art Zake reported that the data on EN 1639 is as interesting
as you hinted last fall. Unfortunately, illness prevented my
attending the meeting, and I am writing to ask if you can make a
copy of the report available to me.
Hwy thanks.

‘uv‘ll

Sincere ly yours,

.

.

“Al-runtrw'mwwwrr-vw.

arm

.......,_.,&lt;

wwmm~mmwmwu

Max

Fink,

M.D.

Professor of Psychiatry
MP:kt

me 7-:

.

-

,-.

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                    <text>. "*0...”

V.“

..

,_..

.w

H.

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.--.,

a.

.5

..

v.

-...,,.,-,

,

.

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y

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,

=

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.

”r,

February 23, 1971
Dr. Walter Essman

Queen's College

Flushing,

New

York

Dear Walt,

sw'associates and I very much enjoyed your visit, and
forward to our collaboration in studies of the BCT process.

we

look

To confirm our understanding, we will re-write the protocol of
our next study to allow the collection and assay of CSF before and at
various times after seizures. We will be responsible for the behavioral,
memory and EEG data, trusting to use your facilities for the chemical

assays.

practicable, you or one of your associates, will
technician who will be appointed to our staff. I would
appreciate your recommending a salary range and working hours; and
we will establish the salary and perquisites.
As

soon as

recommend a

The Association is a non—profit corporation which supports various
research efforts in mental health and for the past few years has assisted
I am pleased that the Association will
me in supporting this ECT program.
appoint you as Consultant in Biochemistry, for an indefinite term at an
annual salary to be negotiated.

While our funds for equipment are limited, we are more liberal in
”supplies” and "personnel” and should be alle to honor such reimbursement
requests as may be agreed upon.
We

look forward to working together. In the event the data is
it has been our practice to defer the presentation to the

publishable,

scientists most intimately responsible for the data collection. I would
results will warrant publication and further study, and in the

hope the

processing of support applications, I would urge the use of the agency
of IAPR.
I believe

association, as
My

this is the essence of our discussion.

do

my

co-workers.

best regards.
Sincerely yours,
Fink, M.D.
Executive Director
Max

Mszt

I welcome

this

�</text>
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.

a
.

...-.my..~wvwvnw,....

February 19, 1971

.r-en—«mqu...._.-:W—«rm».

Dr. Jan VolaVka
York medical College
York, New York

How
New

Dear Voita,
mwmpnmwwwnww

n-w-wrwv

_--m

.

seminars in Psychiatry, a new quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I am pleased you have accepted the invitation
to contribute the report on "Neurophysiology of ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120-160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

meet the publishers deadline, can you make a
by the end of June?
To

.u
1‘

.A

~vwa-wm-wvvrv-u

draft available

It is a policy of the seminars to re—issue reports of general
the
interest in hard cover. If we are successful (and I anticipate
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.
I

ammo-awn-

hope you can

join us.
Sincerely yours,

2‘:

u

u-wzw-

.

Max

ﬁrearm

-»'.m.

'4‘

”E‘N'1‘1

a...

.m—y-

.r-W-um

w‘

9

-‘J‘W‘f‘

Fink, M.D.

Professor of Psychiatry

.;

MFtkt

�</text>
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                    <text>February 19, 1971
Dr.

Ferris Pitts

Washington University School of Mbdicine
660 South Kingshighway

St. Louis. Missouri
Dear Dr.

mm

a
~:L

.w.

57.

“may

“.1.

,a‘
(

WWI-V

Wnrva"

Pitts:

Seminars in Psychiatry, 3 new quarterly publication edited
by Milton Greenblatt and Ernest Hartmanu, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I am pleased you have accepted the invitation
to contribute the report on "Medical Aspects of BCT”. The notes in

the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200~3OO

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced page: (including

7

($11?"ng

63110

To meet

citations).

the publishers deadline, can you

by the end of June?

make a

draft available

"m"

maumnm.

47

m

,5.

an!)

W

It is

a policy of the seminars to re~iesue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

'01

I

x...

V.

;L-v

hope you can

join us.
Sincerely yours,

nz—w-m-wwm

I/rJ

en;

"r“:

Max

mm.

.IWV.‘7

‘HT’E'T

a
U-Z'

a.

WWW/1’

‘34

‘:

«um-"c

--

.7“!

"my"

Fink, M.D.

Professor of Psychiatry

an'

MF:kt

�</text>
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                    <text>February 19, 1971
Dr. Joyce Small

Carter Hospital
Indianapolis, Indiana

LaRue

,u
..

NLJq-yInLL-I

L"¢I~{"

"Jl‘

«aw-:12.

-,:r
\r
.1

“ygmﬁ'ﬂ”

~'E‘1-".G"I‘_'!"‘7"

‘

‘qua-uey

an?!

Dear Joyce,

Sbminars in Psychiatry, a new quarterly publication edited
Greenblatt and Ernest Hartmann, has suggested that the
Milton
by
be devoted to Recent Progress in
first issue of 1972 (February)
am
I
pleased
you have accepted the invitation
Convulsive Therapy.
Results" Indoklon (vs. KCT)".
"Clinical
on
the
report
to contribute

notes in the outline are suggestions, and you are free to expand
on the topic as you wish.
The volume is usually 120-160 typeset pages, equivalent to
200—300 typescript pages. Your report should range from 25 to 30
double spaced pages (including citations).

The

To meet

the publishers deadline, can you

by the end of June?

make a

draft available

I.
w
-,

y
a;

'Kauc'qa

-'
o;

“L!“

.

a policy of the Shminars to rewissue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

It is

"jﬁ"?1"!‘l'_

"
r?

I

hope you can

join us.
Sincerely yours,

u‘f'A‘szﬂ

:'
.

‘-

'rﬁawumz'

Fink, ELI).
Professor of Psychiatry

Max
FCWJ.‘

Mime-:5}.

"Ref:

rmmmlwaw'

in?"

7W}
laws

MF:kt

�</text>
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                    <text>February 19, 1971
Dr. Richard Abrams
York Medical College
York, New York

New
New

Dear Dick,

seminars in Psychiatry, a new quarterly publication edited

by Milton Greenblatt and Ernest Hertmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I an pleasedyyou have accepted the invitation
to contribute the report on "Clinical Results: ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.

is usually
typescript pages.

The volume

200~300

120«160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including
To meet the publishers
by the and of June?

citations).

deadline, can

'

you make a

draft available

It is a policy of the Seminars to re~issue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

.

Mvw

5)."—

�</text>
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                    <text>February 19, 1971
Dra. Rhea Dornbush and
New
New

Stanley Feldsteiu

York Medical College
York, New York

Dear Rhea and

Stanley,
seminars in Psychiatry, a

new

quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. 1 am pleased you have accepted the invitation
to contribute the report on "Memory and ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

To meet the publishers deadline, can
you make a
by the end of June?

draft available

It is a policy of the seminars to re—issue reports of general
interest in hard cover. If we are successful (and
I
the
volume to have widespread interest), the volume shouldanticipate
then be
cited both as a periodical and as a book. assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Max

Pink, 5.9.

Professor of Psychiatry

Mszt

�</text>
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