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                    <text>September 5, 1970
Dr. William Tabor
A. H. Robins Co.
1407 Cummings

Richmond,

Virginia

Dear 3111,

In Istanbul, I first heard the summary data of the studies on
butaperszine in Istanbul, Furnington and St. Louis, including a most
interesting comparison of the data with that of Denber - Bente. All
Keskiner presented the data well, and I am writing to suggest that
you will find the report of special interest. I am sure he or Tursn

Itil

will
My

make

it

available.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>w

...

we,

r
A-

“m"v—V‘V'

'1.‘w—’meK-'

1'1"

September 3, 1970

"‘"lr‘vwm.

WWW

—-r~w-—

.-

‘

Durrin, Chief
Investigations Division

Mr. Kenneth A.

Compliance

United States Department of Justice

Bureau of Narcotics and Dangerous Drugs
Washington , D . C . 205 37
Dear Mr. Darrin:

rv-mr’ww.

WW

to use import permit #2532 on this trip and an
and green copies, to request their cancellation.
both
the
yellow
returning
I was unable

Thank you

for your cooperation.
Sincerely yours,

mmmw—m-

Fink, M.D.
Professor of Psychiatry

Max

”ﬁlm
one. (2)

�</text>
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                    <text>September 3, 1970
Dr. C.

J. Miras

University of Athens Sdhool of Medicine
Department of Biological Chemistry
Goudi, Athens, (609), Greece
Dear Costas,

Enclosed is a copy of the 1969
I do not have the 1970 list.

list of

NIMH

cannabis grantees.

It was a pleasure to work with you in Athens. I will approach
the contract people for an adjustment of our project and advise you as
soon as I have any information.
you for your thoughtful
courtesy and the time you spent with us.
My

girls thank

My

best regards.

gifts,

and

I, for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kt

enc .

your

�</text>
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                    <text>v.

.

mmsm.--mW—wwww...s-.ww.~...-.,.w

Septenber 3, 1970
Dr. Arnold

J.

Mandell

University of California,
P.

O. Box 109

San Diego

LaJolla, California 92037

owu—PWWrsw

.“ww...

Dear Arnold,
I look forward to seeing you in sunny California in February.
There are two topics under study here that would interest the Society.

l) Antggonists in Opiate Dependence: The conditioning model of
opiate depen ence suggests that ”do-conditioning“ could occur if self-

stimulations (needle + drug) went unrewarded repeatedly. Successful
treatment of opiate dependent subjects with narcotic antagonists
(cyclazocine and naloxone) provides support for this theory, and the
basis for a useful therapy in this and other addictions (as amphetamine
and alcohol) (presented with A. M. Freedman).
Convulsive Therapy:

2)

Recent modifications of convulsive therapy

(unilateral convulsions, multiple monitored seizures, inhalant induced
seizures) have focussed interest on the relation of memory change,

altered brain function (EEG) and behavioral change (improvement).
Unilateral induced seizures produce significantly less change in various
asymmetric EEG changes and equivalent behavioral changes
to bilateral induced seizures. This dissociation of therapeutic and
”side" effects allows multiple seizures to be given in one sitting -

memory

tests,

with therapeutic benefits. These observations are of interest to the
theory of convulsive therapy and to the relation of brain function and
tests of memory (both immediate short term and delayed).
I
My

trust that either topic will interest the

members.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>September 3, 1970
Dr. Paul Janssen
Janssen Pharmaceutics

Research Laboratory

N.V.

Boorsc , Belgium

Dear Paul,

First of all, let

of the

CINP.

have selected.
My

I can

me congratulate you on your election as Treasurer
think of no one more qualified that the College could

interest in the classification of novel

compounds by EEG

criteria

to review the printed data on sulpiride. It has been
studied extensively by P. Borenstein who has found interesting EEG changes
and for this reason the compound was brOught to my attention by an American
pharmacologist in the v.5. You may recall that I discussed this compound
with you in Prague and I am writing to request any proprints or published
data regarding the pharmacology that you may have available from your
laboratory.
has recently led

me

I would be most grateful if you might also list the
of your acquaintance who may have worked with sulpiridc.
My

personal regards to your wife.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

names

of investigators

�</text>
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                    <text>September 3, 1970
Dr. P. Simon
91 bd. de l'Hopital
75

Paris 13, France

Dear Czardas,

It

was a pleasure working with you once again. While the program
was larger than we both wished, I left with the feeling that
meeting was a successful one. I know that my family enjoyed Prague

in Prague

the

very much.

You may

recall that

stand that the

subjects.

The

I discussed

my

compound has a wide range

interest in sulpiride.
of psychoactive

literature is quite confusing and

I am

I under—
effects in some

writing to ask for

any information that you may have available. I would appreciate any preprints and reports regarding studies from your lahoratories. Also can
you tell me who may have carried out clinical studies?
My

best personal regards

United States you will favor

and I hope

me

with a

that

visit.

on your

next

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

visit to the

�</text>
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                    <text>September 3, 1970
Dr. Hans Hippius

Nervenklinik der Freien Universitat
Ulmenallee 30
1 Berlin 19, West Berlin
Dear Dr. Hippius:

First let

me

congratulate you

on your

election

as

President-

implied criticism of the
Elect of the
had
more
to do with the patent
actions
nominating committee's
America, particularly
from
CINP
North
of
the
rejection to Fellows
of your nomination
criticism
than
any
the United States, rather
which I endorse
nominations
both
or that of the new treasurer,
GIMP.

You

know,

that

my

heartily.

I am

As

writing because

I

am

interested in the

I discussed with you, the data suggests that

new drug,

it

may

psychoactive properties and as such I an interested in

sulpiride.

have unique

its

EEG

profiles.

I would be grateful for any preprints which you may have of
your work or that of Dr. Degkewitz, as well as any pharmacological
data which may be useful to me.

Also, I would appreciate the

may have

It

studies this

was fun

names

compound.

German CINP

My

and I hope that I will
see you sometime soon in your new laboratories

sessions

—

interest to participate

once again

the ones in Nurenherg were most stimulating.

best wishes for your success.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HFtkt

who

getting together in Istanbul

have the opportunity to
in Munich. Perhaps it would be of

in the

of any investigators

�</text>
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Dr. G. F. Blane

Clinical Research Co-Ordinator
Benson Lane

Hull, England
Dear Dr. Blane:
we

would

studies of

your copy

like to continue our exploration of antagonists

M5050.

I have

is enclosed.

by

obtained an import permit (#2533) and

Can you make a small supply

available?

available a description of the completed animal
toxicology, and a description of the fbrmula, chemical synthesis (in
narrative outline or literature references), address of site of
preparation, and a copy of labelling data. I will need these for
the U.S, F.D.A. to file an IND.
I trust these are the next steps, and would like to proceed.
Can you make

You

will note that the permit lists

M99

be ignored.
Many

use of

thanks for your cooperation.

this interesting

compound.

as well -

this is to

I hepe we can make some

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt
611C 0

clinical

�</text>
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                    <text>l

September 3, 1970

Dr. A. Bruner

Experimental Psychology
Lovelace Foundation

5200 Gibson Blvd., 8.E.
New Mexico 87108

Albuquerque,
Dear Fred,

In my recent travels I visited the harmacology laboratories of
Organon in 055, Netherlands and net Dr. venReCzen. He has a well
equipped neurophysiology center and is specifically studying psycho~

active drugs that seen to alter
and compounds were new to me.

memory

processes.

Some

of his techniques

I described the 1970 Aspen Brain Research meetings
with such enthusiasm that he inquired as to the possibility of his
attending in 1971. I am writing to ask how this can be arranged. I
believe he can make a useful contribution, if asked.
I found

that

Dick Rech called me in June and we outlined some suggestions for
a symposium on drugs, brain function and EEG measures and I trust the
program will gel.

project? We had
great difficulty in obtaining a continued supply of naloxone, and only
recently were able to get a fire comeittnent for another year.
what progress has been made on the addiction

My

best regards

~

and

my

thanks for your cooperation.

Sincerely yours;
Max

Fink, M.D.

Professor of Psychiatry

Mszt

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                    <text>September 3, 1970
Dr. J. R. Wittenborn
Rutgers ~ The State University
New Brunswick, New Jersey 08901
Dear Dr. Wittenborn:

It was great fun in Istanbul, and I do think Turan did a most
admirable job in organizing such a fine meeting. I an writing about
two different thoughts, and ask your advice.
1. In Prague, I met Dr. Peter Fell, a research director of Organon
(Netherlands). Dr. Fell is a most knowledgeable psychopharnacologist and
I believe can contribute to our ACNP sessions in Decenber. I would like
to invite his attendance and ask that you send him such forms and notices
as he may need. His address is:
Dr.

Peter J. Fell

Basic

Human

N.V. Organon

Research Department

Oss, Holland

2. You will recall that l have been posted as Chairman of the ACNP
Nominating Committee. In the business meeting of the GIMP, I was impressed
by the totally undemocratic and restrictive nature of their nominating
procedures, and was stimulated to think of our own procedures. Our own
method is much better, but perhaps it can be enhanced by an invitation to

the membership to recommend nominees to the Nominati z Committee. If it
is not too late, would you accept a request for a mailing of the enclosed
note to the members; I am aware that it may be too late for this year, and
will not be disconfeted if unfeasible.
Thanks

for your coOperation.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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«

1

,.y___1-__,w—-W

.

-w-ww~r“w“mww

n...

w'ﬂ-IF-m"

,.
.7

rqvww-u-nvvgyw-nmw-mraw

1-

September 2, 1970

‘

Queen's Printer
Ottawa, Canada

E

Dear

Sir:

would appreciate a copy of the LeDain report,
an enquiry into the non—medical uses of drugs, as recently puhlished.
Would you advise us as to the proper procedure to follow ?
We

Thank you.
WWF"EWW'SJ'PAWW'MP¢VF"W1

Sincerely yours,
Max

-ngm—n~mw

Pink, M.D.

Professor of Psychiatry

WW.

mf/

�</text>
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Dr. John L. Schimel, Editor

Career Directions

40 Gramercy Park North
York, New York 10010

New

Dear Dr. Schimelz

Enclosod is a corrected capy of the summary "Toward A
Rational Theory of Behavior". I regret that the previous
copy which was submitted hurriedly had many errors.
I

trult this

new

draft is satisfactory.
Sincerely yours,
Max

mm,

mm.

Professor of Psychiatry

MF:kt
011C.

�</text>
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                    <text>September 2, 1970
Dr. Arnold Friedhoff
550 First Avenue
New York, New York 10016
Dear Arnold:
amount of $10.00 from William E.
Bunney, Jr., H.D. who has accepted membership in the APPA.
Please add his heme to the membership list.

Enclosed

is a check in the

The address of Dr. Albert J. Silverman should be changed as
indicated on the attached card.

Sincerely yours,
Max

Fink, M.D,

Secretary

MF:kt

enc .

�</text>
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                    <text>September 2, 1970
Dr. Muaaki Kato
Chief, Addlt Mental Health
National Institute of Mental Health
l~7-3 Koonodai, Ichikawa City
Chiba—Ken, Japan

Dear Dr. Kato:

It

to seeing you in Ann Arbor in November.
will give us an Opportunity to discuss Dr. Miura's application.
I look forward

As I

wrote,

it

will not

be possible

to arrange for

an

additional

facilities
fellow in this laboratory until
The new facilities are not available to us until late in
1971 or 1972, at the earliest.

expand.

our new

give us space to

Sincerely yours ,
Max

Fink, 34.9.

Professor of Psychiatry

Mszt

�</text>
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                    <text>September 2, 1970
Dr. Shiroe Miura

Department of Neuropsychiatry

Tokyo Medical College Hospital

6u7-1 Nishishinjuku
Shinjuku~ku, Tokyo, Japan
Dear Dr. Miura:

It

of you to apply to work in this laboratory,
you have obtained funds independently.
As
wrote, however, we are unable to accommodate any additional
staff until our new facilities are completed in 1971 or early
and

it
I

was kind

is useful that

1972.

As

plans

I

will see Dr.
fully with

more

Kate in November, I
him at that time.

will discuss your

Sincerely yours,
Fink, ”.0.
Professor of Psyohiatry

Max

MF:kt

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                    <text>August 20, 1970
Mr. Robert

Petersen

Grass Instrument Co.
101 Old Colony Road

Quincy, Massachusetts
Dear Mr. Petersen:
one Grass Mechanical Timer, Model MT7A,
Serial No. 70208. We would appreciate your having it
repaired and billing me at the above address.

Enclosed

is

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>E

g

E

E

E

August 3, 1970
i

”“5“

"-1-“.

W

""‘ﬁ'vmfﬂdr'd’aJ'Fu-JKWu'yy‘n-w

Dr. Jack Freund, Vice President

A. H. Robins Company
1407 Cummings hrive

Richmond, Virginia 23220
Dear Jack,

I have read the reports on sulpiride (Dogmatil) with interest.
data consists of translations from French of 17 clinical studies
and one animal assay, published 1968-1969. The principal clinical
reports of Borenstein gt_§&amp;; (Ann. Med. Paychol., 1: 90~99, 1968;
and 2; 560~74, 1968) are frequently cited but are lacking in this
The

collection.

In the continental manner, case records are cited in general
terms and it is difficult to assess the data. Four groups of patients
have been treated: schizophrenia, depressive psychosis, depressive

neurosis and neurovegitative disorders.

I found the reports of Collard (1969), Mathey gt §£;.(19693 and
Naviau (1969) best for clinical material, and that of Borenstein 33 a1.
(1969) for an animal EEG study. From these data, it is probable that:

l. sulpiride,

300-1600 mg/day,

is

an

agent, with alerting and stimulating features;

active antipsychotic

2. it may have less potential for parkinsonism or seizures
than other active antipsychotic compounds;
3.

it

has antidepressant

activity, particularly in agitated,

elderly patients (Renault. 1969); and,

4. it has some anti-vertigo activity
anxiolytic features in neurovegitative states.

and may have other

citations are difficult to interpret, since the reader is
faith in the observers (it is assumed that they are known,
or that their clinic will carry the weight of authority behind the
observations), and controlled data are not presented.
These

asked to have

�-"-~“"W«W"‘

"‘N‘”V~w- "W- \"n'

s

'

u

.

~

.

‘YW‘WV1”'WWx-r4umw"‘ﬁwa-H'll'xw'va u.1~~r)'w'-UL-rwwmuw—-V". -.wo-u~.~u-‘_..,ru

“—um-v-uwr

WM!"

n;
,1
&lt;

anvvnrurv-

"yur'""b.'z

my...“

-2-

Dr. Freund

August 3, 1970

I have known P. Borenstein since 1958. He is an able electroencephalographer and clinician. He is dour, carries a heavy burden
of studies, publishes often and has well trained European assistants.
In Liege, in Harch 1959, I heard him discuss a new, all-purpose
psychoactive compound, with well defined EEG activity. I don't
recall the name of the drug, for he told me that the compound was
not available for American studies; but I believe it must have been
sulpiride. His enthusiasm did not get a good reception, since many
in the audience were preoccupied by other new compounds, chiefly
pimozide and fluspiriline, two Janssen compounds in early clinical
trial. (The conference was in Liege with Janssen support, and many
of the participants were his investigators.)

Collard’s report is also a good one. I know the director of
his choice, Professor Bobon, as well as his son. They are enthusiastic

and probably able psychoPharmacologists, and perhaps these observations
should be treated seriously.
.

If

you seek another psychoactive compound, the data of these

studies are sufficiently supportive of a broad spectrum antipsychotic
(and antidepressant?) to warrant further study. It also has interesting
anti-vertigo properties to support its antipsychotic potency.
I would suggest Borenstein's initial reports he read and his

present views be obtained.

Also, the present views of Collard and

to visit these centers, to
discuss the clinical material in detail, and to assess comparisons
with other active compounds in the same clinics. In the case of
Borenstein, it would be interesting to review his EEG material.
Bobon and Naviau.

It

may

be useful

I am attending the CINP in Prague in midsAugust. As this is a
biennial Opportunity to discuss new compounds, I have checked the
list of titles and sulpiride appears only once. J. M. Sutter, g£_&amp;l;,

of Marseille are reading:

effects of

a new drug:

”Controlled study of the psychotropic

Sulpiride.”

for the opportunity to review this material. It
that I should take better notes at huronean clinical
meetings, and will try to do so. (I am returning the translation
separately.)
Thank you

reminded

My

me

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

cc:

Dr. Tabor

�</text>
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                    <text>August 3, 1970
Dr. Noreen

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Norman,

have completed the next step in the EEG profile analysis
of CP 14,368. In a comparison of single 250 mg oral doses in
male volunteers, we did not elicit a systematic EEG pattern,
although the usual behavioral and BBQ effects of a placebo were
we

inhibited.

Failure to

or the dose of

elicit

CP

the profile may relate to the sauple site
to the possibility that at this dose,

14,368 - or

its central effects

are variable and unsystenatic.

.

mw”

-ww-wn

ww-ymw.r'.

I an not convinced that the sample site is too snail, since
elicited a well defined profile with the same subjects in
another compound, under the some conditions. If the problem is
the dose selected, then we should consider a repetition of the
study at a higher dose or a multiple dose study.

we

I would like the opportunity to meet with Al ﬁeissman and
other scientists at Pfizer with an interest in C? 14,368. This
will make it possible for no to check my experiences with theirs
and provide the basis for recommendation.
I will be away until September 1. but would like to arrange
1 meeting,
that is possible, early in September. Separately
I am sending you three copies of the data books and the summary

if

report.

Thank you for your cooperation ind
examine this interesting compound.

for the opportunity to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
cc: Dr. Berger

�</text>
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                    <text>August 3, 1970
Dr. Hermon

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Hermon,

Separately I as sending you three copies of the summary
report and the statistical data of the EEG studies of ore!

thiothixene.

s pilot phase and a preliminary
These data become the basis for the study

As you know, we undertook

profile study.

presented here.

profile of a single 10 mg dose of thiothixone is
cleerly defined, distinct from placebo, and identical for both
the capsule and concentrate formulations. The profile of
thiethixene is consistent with the sntipsychotic class of drugs
in our published classifications. (Ann. Rev. ﬁtment” 9:
The

EEG

241-258, 1969).

I went to thank you for the opportunity to undertake this
took much longer than I anticipated.
study and I regret that
much
and I am pleased with the outcome.
we
did
learn
However,
very

it

My

thanks for your coooeretion in this study.
Sincerely yours,

u
w

.&lt;.-»-

Fink, M.D.
Professor of Psychiatry

Max
"ﬂ'ml4lmﬂ'w’m”4m‘

VIM-vrmmw‘r

-

Mszt
cc: Dr. Berger

�</text>
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                    <text>nxrm

.

v—

‘

»

--——

rr—twwu-w-mwv.v- w, . ewpu- w. m —

November 30, 1970
Dr. William Guy

Biometric Laboratory
1145 19th St., N.W.
Washington, D.C. 20036
Dear

Bill,
Thank you

for the print-outs

and the cards of the

Hamilton data on our ketipramine study. The data is
most interesting and clear. I have a question about the
what does "p" or "g" mean for ”type”?
summary letter
In checking the new manual, (which is most useful), I
could not find these symbols.
—

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>ii

11

-m"-AW-»~N_J-

mmw

v

-

r
-.

v'm.r‘v"v'wnwmﬁ‘5rvrﬂ

November 30, 1970
'1
s

Dr. Chris

Zerafonetis,

M.D.

University of Michigan Medical Center
Department of Postgraduate Medicine

Ann

Arbor, Michigan 48104

Dear Chris,

that

I very much enjoyed the sessions in Ann Arbor, and regret
I was unable to remain the full week. I look forward to

the publication of the Proceedings.

Enclosed is a draft copy of my report, "A Rational Therapy
of Opiate Dependence: Narcotic Antagonists”, for your consideration
for the volume.
The unusual interest in methadone surprised me.
practitioners are accepting methadone maintenance as

Many

a quick

cure of the opiate addiction problem. It is a facile solution,
but one which promises much more than it can deliver. But in
our experience, it merely exaggerates the problem and delays
any definitive solution. With all their limitations, the
antagonists provide a possible "real" solution.
I trust the report will be acceptable, and that any
summaries or overviews may reflect the dilemma and its doubts

that trouble us.
Again,
meeting.

my

congratulations on the organization of a fine
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>November 29, 1970

Dear Bob,

It

and I am

has been some time since

we

have heard from Texas,

writing to bring you up~to~date with the programs here, and
to ask if your plans for 1971 are sufficiently clear to be discussed.
I have just written to Mickey, and have offered him a position in
the Division.

wuw

wmypwwr.

»

1";"0‘merélwmw‘

During the past month we have negotiated an agreement
with Albany that permits us to assume responsibility for Kirby
Hospital-- training and research- and the necessary clinical
programs. We plan to start with the MMHC units (5 &amp; 6): we will
name the unit directors, send residents from the MMHC pool, and
be responsible for teaching and treatment. The director will be
Kesselbrenner, who will be part of the NYMC faculty. We asked to
have the funds through the College but this was refused, and
we will appoint to their budgets. All appointments will be joint, and
for the two units the appointments will be to the Division of Biological
Psychiatry.

1,2,3 or

We

do

not

know whether we

will divide the

4

units into

number depending on the staff we can recruit
and the type of research programs we wish to start. ECT and penicillamine
4

sections, the

are already projected;
Would you

studies are in the planning stage.
like to join this Division this summer ?
new drug

If so, I will be pleased to

work out the details. (There are so many
other projects in the works, that the choice is a good one, now that

we

have some funds
Keep

again).

well,

and

write soon.
Sincerely yours,
Max

Fink, M.D.

�</text>
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Dear Mr. Poterba,

I regret that my schedule of appointments made it
you in person for your thoughtfulness in making
a drug administration kit available for this laboratory. It is
a useful addition to our facilities, and I thank you for your con-

difficult to thank

sideration.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

mf/

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                    <text>November 24, l970

Dr. Sheldon Gaylln
Dlrec+or of Psychlafry

Grasslands Hospllal
Valhalla, New York l0595
Dear Shel,
am pleased To subml? my appllcallon for appolnfmenl
to fho Dlvlslon of Psychlalry 5+ Grasslands. l hesllafe lo
submlf lelfers of recommendaflon, ofher than Al Freedman's,
for any ofhers would be redundanf and BEE formg.
I

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlalry
MF2kT

�</text>
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                    <text>November 24, i970

Dr. Sheldon sayl'pn

Grasslands Hospital

Valhalla,

New

York

Dear Shel,
i

Abrams

pleased to recommend the appointment of
to the staff of Grasslands Hospital.

am

Dr. Richard

Dr. Abrams completed his residancy in psychiatry in our
Department in l969. He has been a scientist of the Division
of Biological Psychiatry since l968. He completed two years

military service.

Since |968 he has been the project director of our
study program. He carried out this study well, and has
written more than five fine reports.

to

He

has Just been qualified by the Boards and
his promotion.

recommend
l

heartily

recommend

l

was

his appointment.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kt

ECT

pleased

�</text>
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                    <text>Fﬂ'wxwmw

.—

Novembar 24, i970
5

Dr. Sheidon Gayitn

Grasslands Hospifai
Vaihaiia, New York
Dear Shel,
I

am

pleased

To recommend Dr. Arthur
He compiefed

to fhe sfaff of Grasslands.

Zaks

for appoinfmenf

his residancy in our
Departmenf in I968 and has been an acfive researcher since i966.
He is one of +he nafion's principal sfudenfs of fhe opiafe
anfagonisfs; has wriffen exfensiveiy on cyciazocine, naioxone,
and heroin; and is now The director of fhe addicfion service
(Ward iE—A) a? The Mefropoiifan Hospifai Medicai Cenfer.
i

hearfiiy

recommend

his appoinfmenf.
Sinceraiy yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kT

�</text>
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                    <text>November 26. 1970

Dr. Sidney Marlin

Central Islip State Hospital
Central Isllp, ﬂew York

Dear Sid,

I have read the list of candidates for membership in the
I believe the committee ban a difficult responsibility,
to select the most capable from among a list of eminent researchers.

ACNP

and

I would like to endorse (if that is appropriate) the nomination
of the following from the list, no scientists whose work I know
and who I believe would contribute to the work of the College:
Samuel Barbados
C. Keith Connors

Ronald S. Lipman
Donald A. Overton
Eugene Stern Paykel

Burton 3. Goldstein
Jerome K.

Joffe

Allen Raskin
Richard E. Schultoo
Andre Villenouvo

Ali Keskiner
Milton Kletzkin

Sincerely yours,
Max

Fink '

2‘1

0

D-

Profesaor of rsychiatry

MF2kt

�</text>
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                    <text>w.

.

m

'T‘v’rY‘VM

v-W-wmmwnmmmaw-w‘
,

,

w .w

m‘wu-wruw-KXVvvn-wv-wwxmv.l- u
-

,

w

v.

v w”w-

um

«w .;i('&lt;.v»wn'v1.

“mum

1:- :.—

mm. ._.. v—v g

x» .-v.--.

~.:

-

November 23, 1970

Dr. Benjamin Pasamenick

Division of Mental Hygiene

80 Holland Avenue
Albany. New York

Dear Ben,
Al and I met with Alan Miller last Monday, and I believe
that a viable relationship between DHH and NUMC is likely. For
my part, I look forward to extending our clinical studies and
residency training activities to the pOpulstions at Kirby.

There are two programs which are of immediate interest.
In 1968, I renewed my interest in ECT and we have completed
a study of unilateral-bilateral ECT. Electrode placement is
significant for memory and EEG changes, but not for clinical
behavioral results, suggesting the feasibility of developing
an accelerated ECT schedule without memory impairment. It is

this possibility

we

are

now

investigating,

and would

like to

extend the study to Kirby. I am enclosing a copy of the report
and the protocol of the proposed study.
we

are also interested in continuing our studies of

hormonal factors in schizophrenia and, as one study, propose
to examine the effects of penicillamine. That proposal is
being revised and I will send you a copy when completed.

It may not be too soon to review the procedures for
experimental studies at Kirby. I have the assurances of
Al Freedman, Alan Miller and of Israel Kesselbrenner, but
an unclear as to any additional steps which may, at this
time, be necessary.
Any

suggestions?
Sincerely yours,
Pink, M.D.
Professor of Psychiatry
Me:

MF:kt

eat

0

»

7

,

,

,

l

�</text>
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                    <text>November 23, 1970

Dr. Hans Lukas Teuber

Professor of Psychology

Mossachusetts Institute of Technology
Boston, Mbssachusetts
Dear Luke,
Thank you for the two sets of interesting reprints.
After a flurry of excited activity, the suggestion for a
conference on ECT and memory is on the desk of Washington's

satisficers.

After a few more weeks, I will try to extract the
proposal from the mountain of papers above it.
my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>November 23, 1970

Dr. Leo E. Holliater
Veterans Administration Hospital
3801 Miranda Avenue

Palo Alto, California 94304
Dear Leo,

After cending you the abstract, ”Alert EEG Classification
of
Psychoactive Drugs", I reviewed the presentation and
believe the enclosed revision and new focus is more appropriate
to the Society.
New

Bioavailability is a principal concern when drugs are
role
prepared in new formulations. If the EEG has a specific
CNS
index
of
be
useful
an
effects,
as
in drug evaluation, it may
and as a measure of equivalence of dosages or dosage forms.

If possible, the enclosed abstract should substitute for

the one sent
Many

earlier.

thanks.
Sincerely yours,
Pink, ”.0.
Professor of Psychiatry

Max

MF:kt
one o

�</text>
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                    <text>Hovember 23, 1970

Dr. William Martin

National Institute of Mental Health
Narcotic Addiction Research Center
Lexington, Kentucky
Deer

Bill,

Enclosed is a xerox copy of the salient documents from
Alan Corporation, relevant to their participation in the
development of a long acting antagonist. As it is unlikely
that we, alone, could obtain such funds or encourage such a
project, we would appreciate your advice.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
811C

0

�</text>
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                    <text>L7:

in:

‘41::

“1

November 20. 1970
The Honorable Melvin R.

Secretary of Defense

Laird

Washington, D.C.

Dear Secretary Laird,

Reports of increasing use of drugs and deaths from opiate
use in Viet Nam prompts me to bring to your attention the enclosed
studies of opiate antagonists. These agents provide a logical
prophylaxis of opiate dependence but do require additional

research effort.

contracts are

now

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

enc

o

eb‘mx.;::~:

its“-

,2,

in progress under New York State
would
be
useful for the Defense Department to
auspices. It
view
towards supporting, encouraging
review the data with a
or undertaking efforts in this development.
Some

.4}.

"tat-ti:

VJ.

ww-

,.

�</text>
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                    <text>v

,- ~wwmm~zv~rvo~w

.

\\-'€-(Mw.Vaalvm'

.

-.-.- Fwy-n

mmv «sh-w" "'lr'x'

.

»

w—w-n

rnr-v

a—

wva..-..- . r.w--ew'.w-'W a... ".17...

:w

l 1..."...— ‘NW “c.

-:

i,

r-.."

November 23, 1970

Va.-

l“-‘.v1y‘~‘

——-. (-u-r.“ ”VVW—gw

Virgil A. Place
950 Page Hill Road
Palo Alto, California
Dr.

Alza Corporation

Dear

94304

Virgil,

I appreciate your interesting suggestion for the development
of a long acting antagonist. As you know, there is a public
committment to methadone, and it may be difficult to achieve the
requested level of support immediately, but I an optimistic that
the interest in antagonists will be re—awakened.

it.

1)

My

associates

have read the proposal and we

will

2) A copy has been sent to Dr. William Martin, for
and comments. Re is on the appropriate NIMH committee.

recommend

his support

will be included in our l971«72 contract renewal
York State Narcotic Addiction Control Commission, for
review on or before April 1, 1971.
3)

with the

A

summary

New

I have read the Alas annual report _ 1970 - and wish to support
your efforts in developing more physiological release forms of
psychoactive drugs. Our interest in the antagonist is part of a
broader interest in the effects of drugs altering the CNS for
prolonged periods for therapeutic ends. In 1964, fluphenazine
enanthate was the first formulation that provided a solution to
the problem of recidivism in seemingly successfully treated psychotics
patients who responded rapidly to treatment and relapsed when they
felt so well that they "forgot" to take their medication. In
numerous studies, many in our laboratories, this formulation has
been successfully applied in patients now in continuous treatment

for

3—4

years.

~

._

.3.

�aa,..mwnv-.N.Wy

—

‘

-2-

Dr. Place

There

It

may

next you

November 23, 1970

is a need for similar formulations for snt1~psychot1c,

anti~epileptic

and

anti-depressant drugs.

be useful to discuss such needs and

are in the East.

applications,

Again, my thanks for your presentation, and I
submit it for support.

am

Sincerely yours,

«-

v

amw‘vv

Max

'1rmnmmmmuumu-mm—v

a
--

'4-1-W‘r

I’l-n:w'lmwrn~iuplnv7—Y

.fF-"wv

-rnrwrvrm-.wrmn

mus-.W-mm-u—M

W"m~’3."'“

-wﬁwyr

Fink, M.D.

Professor of Psychiatry

«w:

Mszt

_.

when

pleased to

..(.,V_-.......r\

"pen-.5

�</text>
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.

.m-wwvw—awm. MW..."

.«r .»

m

a...

November 23, 1970

Dr. James MCGaugh
Department of Psychobiology

University of California at Irvine

Irvine, California

92664

Dear Jim,

tell you that I very much appreciate
candid
and
response to my inquiry. The proposal
prompt
your
for a conference on memory and ECT (ECS) has been favorably
received, and is now ”in process". As soon as I have any
Just a line to

"news",

I'll write or

Many

call.

thanks for your

interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszt

-'-"'—'—mmwu :Vnw- p.

q

way-.2

.mw—

�</text>
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November 23, 1970

Congressman Mario Biaggi
House of Representatives
Washington, D.C.
Dear Congressman Biaggi:

During the past few months, one of your assistants has
inquired as to our progress in developing a useful opiate
antagonist treatment for heroin addiction. On each occasion,
I indicated that there was no need for additional funds.

I now have two proposals for studies which are
in developing a long acting narcotic antagonist as a necessary
in opiate dependence, with budgets of $400,000 a year.prophylactic
At a recent educational session

Scheuer expressed an

for physicians,

Congressman
making

interest in obtaining assistance in

methadone treatment more readily available to the addicts of the
My associates and I are both willing and able to
assist
in this program, using the medical practitioners as methadone
therapists, under prevailing Federal and medical guidelines.
we suggested that such an effort focussed on an imuediate
”solution"
would be of interest chiefly if it provided a basis for the
deveIOpment of a prophylactic approach.

Bronx.

It

may be

their impact

apprOpriate to discuss these proposals, particularly

on your

constituents.

Sincerely yours,
Vita}!

Fink ’

:4. D u

Professor of Psychiatry
MF:kt

�</text>
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                    <text>~m-r-swmm v arm-V.—n- u v ﬁvm‘x

November 23, 1970
The Honorable James H. Scheuer

House of Representatives
Washington, D.C.

Dear Congressman Scheuer:
and concern of the attendees at the Michigan
methadone
was obvious. Your question, that of
conference in
methadone
available to your constituents
assistance in making
with
my associates, and they concur
discussed
was
in the Bronx,
The

interest

in the sense of our discussion: support for the further
development of the narcotic antagonists in exchange for

methadone guidance.

on my desk,
Addiction
Narcotic
York
State
which I
which
and
optimism)
with
Commission
(although
little
Control
would be suitable for support.

I

It

have two

useful proposals for antagonists

plan to send to the
was

New

stimulating to discuss the addiction problem.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

nf:kt

�</text>
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                    <text>'v-AWW

rw—ww—o.

"Wm

~u

w-W,

November 20, 1970

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardsley, New York
Dear Ed,

Last

we embarked on a sequential drug evaluation study
and adolescents. Seventeen patients have been studied,

fall

in children

and a summary of our

initial

data is enclosed.

vehicle, and a summary
patients received Tofranil in liquid forms
and
are enclosed.
Geigy
the
laboratory
record
of each case
Two

study was both difficult and expensive. As Dr. Simeon
has returned to St. Louis, I have deferred further admissions to
the project.
The

I want to thank

you

for your assistance

and encouragement.

Sincerely yours,
Fink, rm).
Professor of Psychiatry

Max

nrzkt
enc o

�</text>
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                    <text>-'.xz--V.~anwvwwrs- rut-r

'

'r'r

1“qu __.,.. w." .,_w, y........_“~-q_~,.qn
V

Nut-"‘1“ .n-a

WWW—"m

war.

.m $-emw-wv»a.»

-w.-

“tent

wsmv&lt;

nvw— «-—=-w-n.4,.

November 20, 1970
Mr. James

J.

Mynatt

Assistant Director
Legislative Council
State of Tennessee

Committee

Nashville, Tennessee
Dear Mr. Nynatt:

Enclosed are two recent reports describing the present

findings in studies of narcotic antagonists.

The use of the antagonists is limited by their short
duration of action. The need for laboratory studies is
great, but these are funded inadequately.

of a long acting depot antagonist will
provide a logical treatment of opiate dependence, particularly of
young persons, and a prophylactic. my estimate is that, with
financial support, such a development may be available in 1972.
The development

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
enc 0

.

7.9.“

A

�</text>
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                    <text>rum

‘T‘iw-vﬂ“

n,‘

«w

-

-

wine-1m

:‘.‘$-uu)'

y 'u; “4.x";

wmmmwsw.weuwy:+_a~‘ruw.’v¢-K'Wru-‘v&lt;'wV"”rr:u‘|.n-'T~WIW rv'vww‘

«Mm

m

I("'arlyF‘-,vv -

1

.77;

.

'."~'-".‘——

r

.,

rm,

November 19, 1970

Dr.

Fritz

A. Freyhan

St. Vincent's Hospital
Street

153 west 11th

New

York,

New

York 10011

Fritz,

Dear

correction for the ﬁinutes will
trust the record reflects our discussion.
Your

For your information, I have asked

the information regarding the Editorial

entered,

secretary to make
journal.

It is clear that

Sincerely yours,

7"“.w—u—vﬂ.

rm.p:"

Max

3.”

mm,

..,

MF:kt

w
‘-

P"»"WF'uI/D—v~

c
»

-‘uTmM'

Fink, M.D.

Secretary

&lt;

me

I

Board of the

,-

~1ﬂm'wmwmguv‘mr

and

the journal is a creature of Dr. Stratton,
that the designation of "official journal" is nominal. In
view of the other changes at Grune &amp; Stratton, it would be useful
Councillor) could review
if you (as Editor-in~Chief and an APPA APPA
and suggest to the
the relationship of the journal to the
which
would
perhaps establish
publications committee a course
the journal truly as the "official journal"?
and

Vnr'M‘I—v'

my

be

.—.~

7-.

~34."

�</text>
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                    <text>w. r."

,

‘m ;u~.-.

,

November 16, 1970

Dr. Lester S. King
American medical Association
535 North Dearborn

Chicago.

Illinois

Street

60610

Dear Dr. King:
Thank you for your consideration of our brief report
on naloxone treatment. We are enclosing an 80 word synopsis

for this article.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry'

Max

MF:kt

,
.

F.’

T'm'v'r/E'uj?‘

�</text>
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E

g

F

E

'-

w—uv'

mmwvz—uwm

November 13, 1970

Dr. Sidney Nerlis
Research Division

Central Islip State Hospital
Central Ialip, ﬂew York 11722

Dear Sid,

I have read the volume, "Non-Scientific Constraints in
Medical Research" with much interest. It is a fine volume,
and serves a need which (I will admit) I did not see until
you brought it to my attention.

m.

in
v
wu—v-

I

You

are also to be congratulated on the rapidity of publication
report published so well, so rapidly.

have never had a

I look forward to the success of the

rsur—nw-nrvn-

volume.

Sincerely yours,
~4mvmmmm-

Fink, M.D.
Professor of Psychiatry

Max
"VII"IN"'v-r'mr.

V'I'cml-

i‘mrm'nr

~“ﬂﬂ(‘~5wwﬂ“s.“r7"rr:

o.

nvuw'mlwc-

mm»

I'W'IWF'W'V".

&lt;

a

mew-Mm-

{W

MF:kt

-

�</text>
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                    <text>November 12, 1970
Mr. Howard Lane
81 Central Park Road

Plainview,

New

York 11803

Dear Mt. Lane:

I

am

I have read your letter with interest,
unable to assist you.

I do not know of a
short of transfusions.

nor

way
We

and

regret that

of increasing red cell cholinesterase,
effects of choline

have not studied the

L—Dopa.

seem of interest and if these are sufficiently
section
advanced, perhaps you have contucted the clinical chemistry
Your

of

studies

NINE.

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>5“wath ,w—.-rr -n.

-.—.

mvm~v~r

mum-u-

'

-

v:

.

.

'

“V"' '-W

‘

.

,

,—_mr~

W.1—,mwwww .vr~.

.

Novnnbar 12. 1970

w—x

Wwww'w‘nv-naa-

;

E

Dr. Daniel P. Bobon

Cliniquo Psychiatriqne
Univnrsity of Liege
Rue SaintvLautent, 58
Liege. Belgian
Dear Dr. Bobon:
Dr. 1:11 has raised a quastion uith regard to our uumaary
in "The Reurolcpttcl", and an I concur with his opinion. tn
writing to ask that..1f reissued, the text be corrected.
q

On

page 14, the sentence,

"It is possible..." omits the

unjor class of thn ncuroleptics (Intipsychotics) and includes
the analgesic:. The untlgcsics havo not been adequately tested
to form a class ~ but the Intipsychotics form our largest class.
are to be congratulated on presenting n fine volume,
a acnnnto of a was: intereuting convucation.
You
My

has: regards.
Stnccrely yours.
Max

Fink, M.D.

Professor of Psychiatry

Hrzkt

cc: Turan

Ma‘w‘aw'

4‘s

Vr’uif‘v

M.

1:11,

M.D.

�</text>
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                    <text>-—-u-

v

a"

saw

----~ '-wo‘..rVw.YW¢7:
&gt;

"my.

v,‘

November 12, 1970

Mrs. Marilyn L. Tinsley

Stanford University medical Center
Stanford, California 94305

Dear Mrs. Tingley:

have re~drafted the

NRIE reports as the rules require,
with the suggestion that one be reported when~
ever the rules allowal The report by Drs. Dornbuah and Freedman
is from my laboratory and should be included with my franchise.
we

and submit

Many

all,

thanks.
Sincerely yours,
Fink, Md).
Professor of Psychiatry
Max

MF:kt

enc .

_

‘—.--|, “m

_,__

N

�</text>
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                    <text>"Mm-"-

nx—an

mm mu“..-

.

_I.

7.

,

_

,

r.

,

.l

.

“www.mw, we“. ”aur.:g2;qusm;

W"..-"

uv'

U,

~

rap-mum‘-

November 12. 1970

mnmv-w—Vm

mem

7

Dr. Allen Rankin
Research Psychologist
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015

Ya

qr

.FWy—v—

Dear Allen,

for the opportunity to read your report on
depression subtypes. Taken together with Jonathan's heroic
effort to be optimistic about the variety of new studies,
your study indicates clearly that the present antidepressant
drugs are an unsatisfactory answer to depressive illness.
In part, this was presaged when, in reviewing the neuro-~
physiology of different psychoactive drug groups for the
ACNP in 1968, I found four drug classes with four different
neurophysiology patterns a reflection that no one treatment
Thank you

“var

.,

_...,.._..._,~.

,1...

_

A

_—..

—

.-..-H.—rv,w-v—u—

was

satisfactory.

.

Vx-wn'rnwv~

.w

.4
..

.0.

a

,ivﬂ-

warm-”v...“

”Wm

The reawakened

interest in

1966-67

in unilateral electrode

in multiple treatments in convulsive therapy led me
to reopen my studies of ECT, and we have made some interesting
observations. It is possible to effectively treat depressive
or
patients (of any age) within 3-5 days, without measurable
made
by
possible
is
Such
treatment
rapid
clinical memory loss.
seizure
of
and
rate
oxygenation
placement,
changes in electrode
induction.
that ECT is the primary treatment for a
It is apparent
and
that drug treatments may be most useful
depressive state,
regimens.
and
maintenance
as adjuvants

placement and

- ECT comparisons are probably useful in
the combinations
delineating the relative dosages of each, andThis
"radical" view
Imipramine

most

suitable for each depression subtype.
the initial startle reaction
it, despite
needing answers are two:
questions
specific

has much to commend
may excite. The

it

.w.-m,1.._...

WNVWW w'o. maln&gt;wwmm

�w.

-lwwww-

ww

“V.

W,”

._....A.,.

.

,~(v,'q

ww

_&lt;,..

,._—._

.t.

,W...‘,_

m

‘.,

“a “j ..

Dr. Raskin

November 12, 1970

-2—

(1)

For each of the

psychotic, schizophrenia), is

3

ECT

depressive subtypes, (neurotic,
equally useful?

(2) To what extent is a supplementary drug therapy
necessary for each subtype; and which ”antidepressant" drug is
most useful?
A direct comparison of EC? and imipraminc should confirm
the superiority of imipramine, as the Greenhlatt-Grosaer and
Shepherd~NRC studies showed. (There are 5 other studies quoted
by Klein and Davis showing ECT equal or better than imipramine.)
Perhaps, the typology and predictor approach is more useful new.

We

‘wwv—mr-wnu

-

y”

Mandela

have tried to confirm the Carney, the Robson and the
predictor scores in our recent ECT study and were

unsuccessful.

is our latest report as sent to the Archives. I
of the active ECT workers, and I look forward to discussing
this work with you in Puerto Rico.
Enclosed

know many

.-—

Again, thanks for the preprint.

.m.

wry».

Sincerely yours,
‘Wv-Fm-Mn

Max

.wrw-v

«ow—pp

mr’

-

:WﬂvT'WTW’WJrV-‘WW_Z~UWMM~

r-u

Fink gen.

Professor of Psychiatry

r,"

‘(F :kt
811C 0

�</text>
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                    <text>c“

&gt;=W1"\W“DX.\YV

-._-.V_._..,u.~;—v.,.

m... ...,. 7-“

,

1/ra”... _M u, a........,:w-wyn: .—
a

he?

m.V‘!-'-c“:v.‘rw—

November 12, 1970
Miss Bernice Scott
New York State Narcotic Addiction
Control Commission
1855 Broadway
New York, ﬂew York 10023
Dear Miss

Scott:

pleased to enclose our report "Treatment of Heroin
Dependence with Opiate Antagonists" which appeared in Current
Psychiatric Therapies.

I

am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc. (5)

�</text>
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                    <text>v

-

x

m- ;"3\ v.

v" w»—

--7-m-&gt;

'u"-“'

wwm

V-“J'\wa:.n:"“-”‘:Wﬁ

,V

a.“

,i

‘

.1; (uwwiiln-MIW,mvv‘” www m-«umu

rul‘w‘w

November 12, 1970

Dr.

J.

York

H. Willis
Clinic

Guy's Hospital

London SE 1, England
Door Dr.

Willis:

At Dr. Freedman's suggestion I am writing to re—open the
negotiations which you held with him regarding an appointment
in our programs on opiate dependence. Our studies have been
extended to encompass marijuana as well as the antagonists,

L~a1pha~acety1mathadol.

If the opportunity to

to you

may

I ask that

you

work in this Department is of interest
write to me.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1mm t. .r ya.

- .

1n'vumt'

-

- .

,-

,

�</text>
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                    <text>“Any—n,”

November 12, 1970

Mrs. Rose T. Goodaon

Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Mrs. Goodson:

I am embarrassed to bring to your attention an arithmetic
error in my requeet for changes in categories of grant
MH—13358-0d. A copy of your signed authorization is enclosed.
If we add the changes there is a $1,000 error (plus $8800 minus $7800).

To rectify this error I would suggest decreasing the personnel
category from $123,695 to $122,695 and the approved changed amount
from minus $4500 to minus $5500 leaving all other categories the

same.

Thank you.

m...

Sincerely yours,

mun—7r”...

*w.

v”,

,

Pink, M.D.
Professor of Psychiatry

Hex

Mszt

�</text>
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                    <text>November 12, 1970

Dr. William Triebel
353

New

East 19th Street

York,

Dear Dr.

New

York

Triebel:

For two years we have been guests at Gracie Square Hospital,
and with your cooperation, have accomplished the mission originally
set - to compare unilateral and bilateral ECT. Our studies have
been gratefying. Four reports are completed, and two are in press.

I

am enclosing a preprint of the summary report as submitted to
the Archives, in part to thank you for your cooperation and indulgence.
Without the help and tolerance of the staff we would not have been
able to succeed.

Because the next phases of the study require special control
we are moving the study to Metropolitan and Kirby

of the cases,

(Manhattan State) Hospitals.
Again,

my

associates, Drs.

and Volavka, and our

Abrams, Dornbush,

Feldstein,

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry
MFtkt

P.S. I

am

Roubicek

assistants, express our gratitude for your assistance.

specially indebted to your support.

many

thanks.

�</text>
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                  <elementText elementTextId="106028">
                    <text>November 12, 1970

Dr. William Karliner

Franklin Road
Scarsdale, New York

20

Dear

Bill,
For more than two years

we

have been gueats

at Gracie Square,

and with your splendid cooperation, have completed the mission set
for us — to compare unilateral and bilateral ECT. Your special
tolerance and cooperation has made this study possible, and I am
deeply indebted. Four reports are completed - two are in press
and our overall report, as submitted to the Archives, is enclosed.
Because the next phases of the study require special control
of the cases, we are moving the study to Metropolitan and Kirby
(Manhattan State) Hospitals.

Dick, Rhea and

thanks.

My

my

other associates join

me

in expressing our

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>-

, 'ﬁu’i‘v

.«

-vvszr—

.

7m. -1vwwm-"‘

~x~

.

4-3-47. ,»

.n

~"n'.‘.w,'_

,

"r vwom-hmr .79—

..

mu‘lmu' .w—ngew wqw—g

.

a»

7M-WK’»;JIL1IM'-

as:

aw r vm: fr:-

,

w 1M2“? N"

rat- luv

7,”...

Novenber 12, 1970
Dr. G.

Harjsrrison

Associate Professor
University of Saskatchewan
Department of Psychiatry
Saskatoon, Canada

Dear Gordon,

I

am

pleased to enclose a draft copy of our

first report

changes, new in press; report on memory changes, also
in press; and a more elaborate summary, as submitted. The path
of current apparently influences the degree of EEG changes,
and the seizure also results in EEG changes (as after flurothyl)
and the separation of these effects interest us now.

on

2r

.
my

We are also interested in Inglis'suggestion of bifrontal
electrode placement yielding (in theory) less memory (and EEG?)
changes and have collected a few cases done this way.
—

.wwmw.‘

war

4
—n'

iww-W

EEG

EEG

Can

Another important issue is the possibility of left temporal
accentuation after ECT with hitemporal electrode placement.
you confirm this observation?

.

My

Inn-y

best regards.

w

Sincerely yours,

01er

r,-.

v-

wwwmwkuarma

Fink, M.D.
Professor of Psychiatry

Max
,:

my

”‘Vw.1~|-':v'zn

new

*

-,er«nv.wnr-'=$::

Mrzkt

-

&lt;

v-r"

' “*W“

�</text>
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                    <text>A

V

”wwwnr.

I-Icvuu-n

,wv

A

mar—w

wt,

November 12, 1970

w

Dr. Charles Shegaas

Eastern Pennsylvania Psychiatric Institute
Philadelphia, Pennsylvania 19129
Dear Charlie,
Would you

letter to

please

make up a form

each member of the

candidates for membership?

APPA

so

that I can send with a
that they can nominate

Thank you.

I

a

Sincerely yours,
Fink,
Secretary

Max

Mszt

M.D.

�</text>
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                    <text>November 12, 1970

Dr.

J.

Willis

H.

York Clinic

Guy's Hospital

London SE 1, England
Dear Dr.

Willis:

At Dr. Freedman's suggestion I am writing to re—open the
negotiations which you held with him regarding an appointment
in our programs on opiate dependence. Our studies have been
extended to encompass marijuana as well as the antagonists,

£~alpha~acetylmethadol.

If the opportunity to

to you

may

work

in this Department is of interest

I ask that you write to

me.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>"r

~

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November 12, 1970

Yi‘v'mruwr',

vwi

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,.

Dr. Lothar Kalinowsky
115 East 82nd Street
New York, New York

wraneruw—

Dear Lothar:

Vw-_—ﬂ\'~"l‘~!"’

“£1.11

WWI-ayw-W

,mr

mtg-V

-

For two years we have been guests at Gracie Square Hospital,
and with your cooperation, have accomplished the mission originally
set - to compare unilateral and bilateral ECT. Our studies have
been gratefying. Four reports are completed, and two are in press.

am enclosing a preprint of the summary report as submitted to
the Archives, in part to thank you for your cooperation and indulgence.
Without the help and tolerance of the staff we would not have been
able to succeed.

I

Because the next phases of the study require special control
we are moving the study to Metropolitan and Kirby

of the cases,

(Manhattan State) Hospitals.

Again, my associates, Drs. Abrams, Dornbush, Feldstein, Roubicek
and Volavka, and our assistants, express our gratitude for your assistance.

Sincerely yours,

vies-wr-

an

Max

Fink, M.D.

Professor of Psychiatry

Hszt

we

wmv

:rrvma

l""

ran.

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’~.;—.-

-“-'nrlg'(rn-

“v.

-v

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7

4'

If,”

P.S. You know how we valued your support and cooperation, for
without them, the study could not have succeeded. Many thanks.

.,

”.7

,e

,V

.

.

.

�</text>
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                    <text>-.:

.

"WV:

wawurm

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u.

_

w," swung.” ‘m.,.,,&gt;£__.,.,_,.,,...,u_..V“_F:ﬂ.

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«any

-.....

7..-»...w

._...._

,,.__,_

November

"‘5'

.rr

6, 1970

Dr. David Lehr, Chairman
Research Committee
New York Medical College
New York, New York
Dear David,
The study "Anticholinergic Drugs, Convulsive Therapy and
Man" was approved September 23,
1968, and initial work was performed by Dr. Robert Levine. The

Alterations in Brain Function in

attached protocol "Multiple Monitored Electroconvulsive Therapy"
is submitted as an amendment of that project. The essential
differences from the previous protocol are:

mmmvwW-n

May

1.

Administration of electroconvulsive therapy
multiple treatments each session.

2.

Addition of newer

3.

Addition of behavioral ratings (Hamilton
Rating Scale for Depression, Beckomberga
Rating Scale for Schizophrenia)

4.

puncture for assessment of
biochemical changes after ECT.

5.

Deletion of syntactic analyses, administration
of anticholinergic compounds.

memory

Lumbar

tasks.

CNS

I request this continuation be filed as an

that project?

Thank you.

amendment

Sincerely yours,

A
V

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

of

�</text>
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                    <text>November

6,

1970

Israel Kesselbrenner

Dr.

Hanhattsn State Hospital

Island

Wards
New

York,

New

York 10035

Dear Dr. Kesselbrenner:
We are submitting the enclosed protocol: "Multiple Monitored
Electroconvulsive Therapy" to the research committee at Kirby
State Hospital for approval. We wish to develop a more rapid and
safe method of administering electroconvulsive therapy with

minimal memory-loss.

the

The

subjects will be those appropriately referred for

staff of

Kirby Hospital.

EC?

by

This protocol (in a prior draft) has previously been approved
the Research Committee of New York Medical College and by the
Commissioner of Hospitals for Metropolitan Hospital.

by

The work will be undertaken by personnel assigned to Kirby
Hospital from the Division of Biological Psychiatry of the New York
Medical College, and will not require direct costs by the State.

us

will need

2

rooms, one

for

an

EEG

libsratory

and one

for

an

interview room; and any modifications will be subject to your
approval and at our cost. We plan to use the available ECT treatment
facilities at Kirby without significant change.
We

are prepared to begin

Thank you

on November 15 1970.

for your cooperation.
Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

HF:kt

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                    <text>November 5, 1970

Honorable Jacob Javits

U.S. Senate

Washington, D.C.
Dear Senator

Javits,

The 1970 Comprehensive Drug Abuse Prevention and Control
Act contains the provision for the establishment of a commission on
Marijuana and Drug Abuse. The efforts of such a Commission may have
a significant effect on future drug abuse laws and community attitudes.
While
is always foolish to volunteer, I am taking the liberty of
enclosing the curriculum vitae of Dr. Alfred M. Freedman, chairman
of this Department of Psychiatry and the mainspring of our studies
of opiates, opiate antagonists and marijuana; as well as my own,
If there is an orderly process in which such recommendations are made,
and if you and your staff deem it useful, I would be pleased to have
you recommend either for service on or with this Commission.

it

Many

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

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                    <text>van—m

w

7,,

vnyw—m

,,,,.

fJ-‘m'

November 5, 1970

Congressman Paul Rogers
House of Representatives
Washington, D.C.
Dear Congressman Rogers,

I

am

myself for your

writing to express the gratitude of

my

associates

and

efforts in re-writing the drug abuse control laws. In
holding the hearings, you gave many scientists and concerned citizens
opportunity to present their views to the Congress. I believe the
final bill is better than the original versions (though far from the
best) and we are grateful for your efforts in achieving this measure
of improvement.

that
bill for

hope

when Senator Hughes has an

opportunity to
again present a
an institute devoted to drug abuse control-the present leadership in Chevy Chase being so inadequate—- that you
will lead your associates in a fair review of that bill.
We

Again, our thanks.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.

an

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                    <text>1,
5

November 5, 1970

Senator Harold Hughes

U.S. Senate

Washington, D.C.
Dear Senator Hughes,

Just a letter of congratulations on your efforts on behalf
of more effective drug abuse laws. Your efforts in reviewing the initial
bill hastily passed by the Senate, and the final bill, represent a
more rational approach to drug control. I hOpe that your suggested
center will indeed come to pass, as it will do much to improve the
quality of the research in addictions.

efforts at developing a successful long—acting antagonist
are proceeding, albeit slowly, and with some optimism. There is still
too little leadership in Bethesda, but we will succeed.
Our

Again, congratulations on a job well done

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>i!”

won.

waxwrvvm-u-wa-w»—rmw-y—m:mxmmvmmwAWN:

.

'

V
.

'

'

r

,

rmwvww-w

'

.

..

,

«mm.

,

"\mw‘WN-«hﬂvar'N-o-HIW

November 5, 1970

Dr. Jonathan 0? Cole

Boston State H08pita1
Boston, Massachusetts

Dear Jon,

Just a letter of appreciation for your efforts on behalf
Americans in achieving a better drug abuse control law. I have
read the Congressional Record and the final bill, and believe that
the differences from the January bill are significant—— much of
it due to the efforts of the Committee I presume.

of

all

I trust that the Committee will not disband
skirmish seems to have been won, but will continue.
Many

now

thanks.
Sincerely yours,
Max

Fink,

M.D.

that a

�</text>
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                    <text>November 5, 1970

Dear Mickey,
The

Enclosed is another piece of fan mail for your answer.
other reprint requests have been answered by Kathy.

Work here is going very well. Dick's ECT project
has completed its ftrst round of studies and the reports are good.
For the next phase we have moved the study to Metropolitan Hospital
and Dick has assumed responsibility for all ECT in the Department.
We are also working on an NIMH Sponsored
meeting that will star these

studies.

Jovan returned to Missouri. I was sorry to see him go,
but his reasons were personal and seemingly unrelated to our work.
Dick has taken over the unit, and it will continue except for the

children's project.

is now ours and the laboratories and the
studies are running well. Stanley and Rhea are enmeshed in their
studies of cannabis and heroin, and Voita is doing the EEG studies.
The computer

EEG

Recently

we

were approached by Sarnoff Mednick to

collaborate in his long term studies of schizophrenia in Denmark. I
had spoken to his co-worker, Fini Shulsinger in the late spring, and
I hope that we can launch a joint project. The population and the
studies should have particular interest for you. Indeed, Voita tells
me that in-a review of some of the data already available, he found at
least 3 boys born to schizophrenic mothers who were rated as psychotic
suring their pregnancy. These should be reviewed.

Our relations with Kirby are still in negotiation. The
at 99 Steeet should be completed by June, or so Al Freedman says.
contracts in Greece and form the narcotic antagonists are approved.

MHMHC

Our

There

is so

much going on and

I sometimes wonder

how

it

gets done- but

Dick asked if we had a position for you. Yes. Let me know
3-4 months before you wish to come and we can work out the details.
Keep up
My

the

letter writing (to the journals, that is.)

best regards.

it

does.

�</text>
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                    <text>November 5, 1970

r

"IX-"Ir

Mr. Neil Chayet
Box 572
1629 K Street H.W.

Washington, D.C.

.

Dear Mr. Chayey,

Please accept my congratulations on a job well done I
I have read the proceedings in the Congressional Record of the last
few weeks, and I was pleased that so much good could come after the
very bad bill of last winter. I trust that the Committee will not
disband, but will continue to express the voice of rational drug
laws.

-

If copies of the final bill

and the Congressional record

testimony are indeed available, I would like copies for reading by our

students.

Again,

my

thanks for your strenuous and

fruitful efforts.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>November

Dr.

J.

4, 1970

F. Remsrque, Vice President

Elsevier Publishing

P. 0. Box 211

Company

Amsterdam, The Netherlands
Dear Dr. Remsrque:
Supplement 23, "A Selected Bibliography of Electro~

encephslogrsphy in

in

1965.

Is

it

Psychopharmecology”, was published
possible to obtain a count of the number of
Human

copies distributed since the printing?

I have been asked if I was planning to issue an up-dsted
version, and I wonder if the interest warrants the effort. Do
such supplements serve a useful purpose?
I would be grateful for your comments.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry
MF:kt

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E

E

E

'»&gt;n9-n'-n

~,—

-

417'?“

__

m'v‘wrsw

Wmm‘ﬂrx -v~:--wv-v-~4x

v-v -

'«s-asapr- ww-nw 'r‘I'V’Y"WF6‘~V;r\Tvr"IIr-w!,~‘K'¢"V'.w.\V‘-.~p'll

November

,

”mu

4,

'4

l-n’xr‘n‘ w-muv .—».

~.

.“ m _.,,._..

~

gnaw

1970

Dr. Turan M. 1:11
Missouri Institute of Psychiatry

Street
St. Louis, Missouri

5400 Arsenal

63139

Dear Turan,

Please read the attached notes from Dr. Sonowski
call me next Thursday or Friday. I will be out of town
until Thursday afternoon.
and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkt
em: 0

,» -

nv

u.‘

,

..

..

,.....~‘y- u—

w‘

�</text>
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                    <text>November 6, 1970

Dr. Samuel Mule
205 Arborley Aye.

Mbrriaville, Pennsylvania 19067
Dear Sam,

Enclosed

is

200 mg £~alpha~acetylmnthadol

establishing standards for urine testing.
My

for use in

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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a»...

.7

,,,,,,,..._,. , M

_

m!,

,

,‘ a...“

Mums». H unvr “qr”...
7,.

,

,

.w

V'wanrv-cﬁuh'wm‘

.

,

,q
. r ,., ,‘____m,_,,,.__
-

-.—...

mtwlm-W-wmx-”

.

..
., ,v,-.v
in .

mu». s."“'i".rm"’~"“
~

November 4, 1970
Mr. Richard

Zirinsky

Chairman, Board of Governors
Gracie Square Hospital
420 East 76th Street

New

York, New York 19021

Dear Mr. Zirinsky:

It is with gratitude that my
and I complete our
studies at Gracie Square Hospital, associates
and relinquish the laboratory
which you so kindly made available. The
Opportunity to study the
treatment programs at the hospital was most
valuable, allowing us
to compare the clinical, memory and EEG changes
in three forms
of ECT.
Reports of these studies have been presented
and

at meetings of
national scientific societies (Eastern EEG
Association,
December 1969; Psychiatric Research
Miami Beach, 1969;
Society,
Eastern Psychiatric Research Society, April 1970). We have
completed four reports (see enclosed preprints)
defining various
aspects of the convulsive therapy process; two are
in
press. Additional reports are in progress and willalready
be forwarded
local

to you

when completed.

We believe that the work done
at Gracie Square Hospital
has greatly enhanced our knowledge of
the convulsive therapy
process, and improved the stature of scientific research
this field. The governmental support we obtained for thisin
project underscores the national and public health importance
of investigations

of this valuable psychiatric treatment.
You will also be pleased to know,
that because of our interest
and the special nature of these
we have recently been asked
studies,
by the National Institute of Mental Health
an inter~
national meeting of the scientists studying tothesponsor
treatment
of
depression, to assess these optimistic ECT results.

�Mr.

Zirinsky

—2-

November

4,

1970

The next phase of the study requires more extensive laboratory
examinations, a larger papulation of long-stay patients, and a timeconsuming treatment method (multiple monitored ECT). For these reasons
we will transfer the project and equipment to Metropolitan Hospital
during the next two weeks, vacating our office at Gracie Square
Hospital by November 10.

wish to express our deepest gratitude for the hospitality,
and active coOperation that you and your staff have
extended to us during the past two and a half years. Drs. Abrams,
Dornbush, Feldstein, Volavka and our co~workers join me in expressing
our appreciation. Without the support and tolerance of the attending,
clinical and administrative staff, this project would have been
impossible; with it, we have once again demonstrated that scientific
research can be successfully carried out in a private institution
We

cordiality,

with private patients and.with important results for clinical psychiatry.
Warmest personal regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
MW:kt

cc: David Shapiro

.

A

nrmm

�</text>
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                    <text>lovember 2, 1970
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
we

have analyzed and re-analyzed the data for

this

are now satisfied that it is presentable.
Don and I would appreciate your comments. I would like
to send it to the Mohivu 05 Gum Pagdbémy, and
if you agree, I will add the citations and promptly send
study, and

it

we

out.

Sorry for the three year delay.

Peale.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt
Enc.

Amob—Fen—DA

Study

�</text>
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                    <text>October 31, 1970
Dear Hi,

last spoke, I

became concerned that you were
between
the College and the DNH. I
negotiations
think I understand your discomfort, and I am writing this note to
bring up to date the state of the negotiations-— hoping thereby you
may be able to accept Al Freedman's reluctance to make any separate
'deala' with Albany until the principal 'deal' is completed.

distressed

6

When we

by the

We have met with Mr. Dubois and Dr. Kesselbrenner on at least
occasions since late spring, the latest on October 1.

There have been at least 4 drafts of 'agreements', with the
from Albany, vitiating completely all previous
received
as
latest,
agreements, and reducing the negotiations to the same state as they

held in 1969, and earlier. I- is clear that DMH is not interested in
an affiliation, nor in providing any funds for teaching and training,
nor in anything more than using the name of the College to bail them out
of a training

difficulty.

I had been hopeful that the College would establish a
direct relationship with Kirby, such that our patients would be treated
on a long term basis at Kirby; thereby allowing my staff to study the
therapy of the severe mentally ill. We did not ask for a research ward;
indeed, we insisted that there he a clinical center first, and that
research only of a clinical nature be encouraged. The first project
that I wished to encourage was the ECT project now at Gracie Square

Hospital.

Since the negotiations have failed to achieve any closure
have moved my project from Gracie Square to Metropolitan

for 1970-71, I

HOSpital.

Both Al and I were dubious that DMH were sincere in their
interest, but favored them to the extent of particpating in the discussions.
The matter has now been referred to the Commissioner with the statement
that Al Freedman sees no point in meeting with anyone else. (I encouraged

this decision).

Perhaps this will

you have contended with

for

clarify the difficulty. I

many

years,

Peace, and Happy Flying.

and admire your

know now what

fortitude.

�</text>
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                    <text>October 31, 1970
Dear Arnie,

Please pay the Hotel Hilton (attention Mr. Paul Steiner)
final charge for the 1970 meeting. Letter enclosed.

$137.42 as the

Please send a list of members, as of the latest date,
to Dr. Charles Shagass for the membership committee; to Jon Cole,
for the Nominating Committee; and to the AMA (address attached).

If you have an urge to invest some of the cash of the
Association, I can arrange to obtain Treasury Billaa for 91 or 182

dollar lots. It seems that you will have no
until late February, and if you wish to buy 91 day
bills, call me. There is no reason to touch the savings accounts;
and the securities are probably in as good a shape as one could
find. It is not prudent to invest in straight securities (the amount
being small) and other funds will do no better. I would suggest,
however, that additional funds be used to invest inn other securities,
and that dependence on one fund is unwise. In March, after the
returns for the meeting and membership are in, we can discuss the
possibility of selling some of the Lehman stbck (they pay their major
days

in

multi—thousand

major eXpenses

dividend in the spring) and investing in another fund.
Peace.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>October 31, 1970
Hr. Jay Cutler

Assistant, Senator Jacob Javits
U.S. Senate

Washington, D.C.
Dear Mr.

law, I

Cutler,

Now that the Drug Abuse Control
would appreciate a copy of the final

You may

recall that

we

legislation has
legislation.

become

are particularly interested in

continuing work toward the development of a long acting narcotic
antagonist, both to treat and to “immunize” against opiates. From
your knowledge of the law, are there any portions of this legislation

utilize to obtain the support necessary for this effort

that

we may

work

thanks for your cooperation, and also for your fine
in assisting the final formulation of this Act.
Many

Sincerely yours,
Mex

Fink, H.2.

Professor of Psychiatry

mf/

?

�</text>
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                    <text>October 30, 1970
Dr. Lester S. King
American Medical Association
535 N. Dcarborn

Chicago,

Street

Illinois

60610

Dear Dr. King:
We are resubmitting our revised draft of "Naloxone Treatment
of Opiate Dependence: A Progress Report", for your consideration
for the J.A.M.A. Your suggestions were excellent, and we have

adopted each one.

Again, our thanks for your consideration.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>October 28, 1970
Dr. Monique Brande

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

Dear Monique,

RE:

Fink (98H7)

Following your recent request, I have put together the enclosed
report of our marijuana studies, and our various interim reports.
The memorandum answers the questions; the reports are all internal
except "Marijuana, Cognition and Perception“ (9-10~70) and "The
BiOIOgy of Cannabis" (5—4~70) which may be quoted.
We

will send subsequent reports as they are produced.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>-1yv.w-rw«'r-'“¥".m'r

,-v.x,u.,‘....m

v

..

October 28, 1970
Dr. Wayne 0. Evans, Ph.D.

Research Institute
of Environmental Medicine
Natick, Massachusetts 01760

U.S.

Army

Dear Wayne,
Thank you

for sharing your thoughts

and your apparent disappointment.

delighted with the quality of the Fellowship, and
albeit expensive
so found our considerations interesting and pleasant,
best
possible
the
and fatiguing. I hope we succeeded in providing
the
increasing
by
College
of
our
base for the continued vitality
As
ably,
so
said
Council.
you
participation of the Fellows in the
not
we had many from whom to choose, and the selection represented
the
nor
pOpular
most
the
necessarily the oldest, the best known,
shown educational
most erudite ~ but those who, by their record, had
and
were responsive
leadership, could make administrative decisions,
who
meet these
could
others
and innovative. That there were many
qualifica—
additional
met
the
men
requirements, I am sure, but these
served the Fellowhhip

I,too,

am

tions of being
recently.

recommended and

not having

do so because two committee
of
end
the month, and we were asked
members were too busy before the
As

for not meeting,

to abide

by

we

failed to

the requirements of the By-laws.

There is an omission from your letter that I noted with some
disappointment - we did institute one novelty, that of broadening
set of
the nominating procedure. I regret that thisbutinteresting
useful
most
was
it
data was not considered useful by yourielf,

to

me.

You must be aware that in nominating Fellows who had not previously
be
served as officers, we provided an Opportunity for new thoughts to

important Fellowship. I am
expressed in the Council of this vital and
nominees, and I trust that
the
confident that the Fellows will approve
service.
our recommendation

will be rewarded

by

their creative

Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

HP:kt

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                    <text>Qctober 27, 1970
Hr. Gaston

Castollanss,

Secratary ﬁencral

M.b.

wprld Songress of #sychiatry
ﬁaxico Slay, maxico
was: ﬁt. Cnscellanos,

of devaleping a symposium on thq "EEG
Mental
Illness”
Catralatas of
is must welcama, and I ﬁaliave a fina,
be
devuloped.
ginaral program :33
Your suggesting

inturesting and mania ha most helpful
than
Rathar
chairmen.
to the orgnnixing
go inta the upccific nominces,
I would commend tha tallawing as most knowleégeable and capabla
saiautiats ané psychiatrist: who could be entrusted with ch: respansibility
Your 113: of namineea 1a

of organizing the symposium.
Turan ﬂ.

Itil,

%.D.

11:1 acubiczk, ﬁ.§.
Chnrlas ﬁhagnss, H.§.
Inn wswald, ﬁ.§.

Turkey

Czachoalovakia
U.S.A.

grant Britain

I also believe that that: men me$t capable act only of
organizing a fine wasting, hut also of raising the monay nauasaary t9
support such an umdettaking~v provided they are invasted rapidly tad with a
well dafined mission.

I look fatward to visiting your unguificant city, and
r¢~nwaken1ng my {and namorieo of pleasant and stimulatiag visits.
Sincaraly'yours,
yiﬂk, gig.
Protester of Psychiatry
23m

af/

�</text>
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                    <text>%

%

i

5

‘

§

5

TO:

A. M. Freedman, M.D.

FR M:

Max

SUBJECT:

Child Psychopharmacology Project

Attached

is

Fink,

a
PsyChopharmacology

DATE:

Outober 26, 1970

M.D.

report on the first year of the Child
Project.
patients in active treatment now, treated

There are 11
by
Drs. Robson and Caztanaga, Miss Formicelli, H.S.w. and Mrs. Korein, M.S.W.
and Boone Durbin, R.N.

I antacipate difficulties in maintaining this special unit
without a replacement for Joven Simeon. In View of the need for
additional staff in other programs, I will recommend discontinuation
of this special project. Dr. Gaztanaga and Miss Durhin will continue
in the adult program; Miss Formicelli and Mrs. Korein reassigned to
the narcotic addiction unit; and Dr. Hobson should be re~assigned
to Child Psychiatry, full time - with reassignment of her salary
from 47—072—5 (narcotic addiction) to child psychiatry or other
departmental funds.
MF:kt

�</text>
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                    <text>%

%

i

5

‘

§

5

TO:

A. M. Freedman, M.D.

FR M:

Max

SUBJECT:

Child Psychopharmacology Project

Attached

is

Fink,

a
PsyChopharmacology

DATE:

Outober 26, 1970

M.D.

report on the first year of the Child
Project.
patients in active treatment now, treated

There are 11
by
Drs. Robson and Caztanaga, Miss Formicelli, H.S.w. and Mrs. Korein, M.S.W.
and Boone Durbin, R.N.

I antacipate difficulties in maintaining this special unit
without a replacement for Joven Simeon. In View of the need for
additional staff in other programs, I will recommend discontinuation
of this special project. Dr. Gaztanaga and Miss Durhin will continue
in the adult program; Miss Formicelli and Mrs. Korein reassigned to
the narcotic addiction unit; and Dr. Hobson should be re~assigned
to Child Psychiatry, full time - with reassignment of her salary
from 47—072—5 (narcotic addiction) to child psychiatry or other
departmental funds.
MF:kt

�</text>
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                    <text>...,,._

v,‘

,.v-v

r—

T

“W”

w.

,..

,

.

vary-.7",-

October 26, 1970

“WW

.
,..

"1,“,

Invn'bwww—w—V’

Dr. James

Inglis

Department of Psychology
Queen's University
Kingston, Ontario
CANADA

Dear Dr.

Inglis:

”Shock. Surgery and Cerebral
I read with interest, and enthusiasm except
for your insensitivity in continuing to use the barbaric non—
descriptive term of ”shoe ”.
Thank you

for your reprint,

Asymmetry” which

My

associates

have

treated

a few

patients with multiple

induced convulsions using frontal electrode placements. While
induction is more difficult, it is practical, however, and
the results comparable to bitemporel and unilateral placements.
We are now studying the memory, clinical and EEG effects in a

systematic way.
A

preprint of our recent data is enclosed.

Again, many thanks.

Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

mrzkt

�</text>
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                    <text>October 26, 1970
Dr. Michael Shepherd
Maudsley Hospital Institute

of Psychiatry

Denmark

Hill,

London

Dear ﬁihhael,

It was a pleasure having you visit our school, and after
hearing your impromptu responses to our questions, I am more
confident that the large attendance the day before was in

anticipation of your participation. Also,

my

best wishes for

the success of your new venture, Psychological Medicine ~ yea,
I have subscribed, I trust in time for the ”special offer”.

I am enclosing a number of additional (older) reprints
on the subject of EEG classification of psychoactive drugs,
as well as a prennrint of a report of an analysis of a new
compound. It has been my custom to review the various drug
classification schemes in my second lecture in a graduate
biological psychiatry seminar. Host published classifications
schemes do not fare welL for their limitations exceed their
utility. The neurophysiology scheme is explicit and testable;
modern techniques provide excellent quantification; and
replication is feasible, limited only by time and expense.

I

commend

these techniques to your review.

Studies of the effects of drugs on sleep by T. Itil
(St. Louis), Ian Gsweld (Edinburgh) and A. Kales (Los Angelea):
on evoked potentials by C. shagass (Philadelphia); on contingent
negative variation by Dougier (Liege) provide parallel and
supporting evidence for consistent neurophysiological effects,
but the data of these studies is more recent, less complete and,
as yet, not well codified.
Again

my

thanks for your most interesting presentations.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

HF:kt

P.S. Could you tell me who the psychiatrist is in Kenya — and his
address if you have it. Do you know him personally?

�</text>
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                    <text>Wyn—w

mun-r—

October 26, 1970
Dr. Harold Heiselas
York State Narcotic

New

Addiction Control Commission

1855 Broadway

New

York, New York 10023

Dear Harold,

RE:

Contract 044116

We are actively pursuing the development of a long acting
narcotic antagonist for the prophylaxis and treatment of opiate
dependence. Our clinical studies with naloxone will be reinstituted with new supplies about November 1; the contract with
Food and Drug Research is operational; and we are negotiating

another with Alza Corporation.&gt;
At

4 meeting we became acquainted with another
ﬂ 5050, developed by Beckett and Colman of Hull,

the June

antagonist,
England, for veterinary use. This antagonist is another ”pure"
antagonist, 16»20 times as potent as naloxone in animal trials,
both abroad and at the University of Michigan in studies by

Villareal.

We have received the cooperation of Reckitt and Colman
to undertake human studies. With a permit to import issued by
the FBN, I now have 10 grams M 5050.

Before clinical assays may be done, the FDA requires minimal
animal toxicology data in 2 species, and such tests have not
been done — they are not necessary in veterinary medicine.
have submitted copies of the available data on M 5050
to the FDA, inquiring as to the minimal testing they would accept
for an IND. On the basis of our discussion and my past experience,
they will require testing in 2 species for 6 months with complete
pathology. Such work is done by various university and commercial
laboratories on a contract basis, and usually costs between $20,000
and $40,000, depending on the species studied.
We

We have written to Dr. Louis Harris of the University of
Earth Carolina for his estimate of the FDA requirements and
cooperation in this testing. He is the pharmacologiat who
developed cyclazocine at Sterling—Winthrop and is the most
capable authority in this complex field.

�~2-

Dr. Meiselas

October 26, 1970

1970~71 contract with the
Narcotic Addiction Control Commission, we requested additional

will recall that in our

You

to purchase supplies of neloxone. Fortunately, Endo
Laboratories were persuaded to make 6 Kg naloxone available
sums

at

cost.

no

We

are writing to:

l) Acquaint the

Commission with our progress and thoughts;

Request your review of the enclosed data, and ask that
an opportunity he provided us to meet with Commission representatives
to discuss this program; and,
2)

Enable us to request use of the naloxone supply funds
for a subcontract for animal pharmacology of M 5050, to shorten the
time from animal testing to clinical trial.
3)

Thank you

for your interest.
Sincerely yours,
Vax Fink, M.D.

Professor of Psychiatry

MF:kt

encs:

FDA

Ltr.

M

Submission
L. Harris

5050

reprints

�</text>
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                    <text>-

.‘Vr‘ﬂ‘UF'V'u-‘l‘”~

‘

w .'\Y‘-‘vr=rwn ,

.r

.

,

.

r

.

v.

.

”new

'wrwva-nu n-nmxm- "wwzxxmmwrmn-rmmemmrmmw
vvxm

October 26, 1970
Mr. Louis Graff, Director
Health Sciences Relations
University of Michigan
Administration Building
Ann

Arbor, Michigan 48104

Dear Mr. Graff:

Enclosed are some of the materials you requested for
the forthcoming symposium on Drug Abuse ~ a copy of my
curriculum vitae and a shorter biography; an extended text,
"Antagonists in Opiate Dependence: A Rational Therapy"; and
some additional background references, including reports
of cyclazocine, naloxone and a recent criticism of methadone

maintenance.

I trust these are helpful.
Sincerely youre,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>VIP-m -'u=?.'m.-

‘

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October 26, 1970
Dr. Michael Shepherd
Maudsley Hospital Institute

of Psychiatry

Hill,

Denmark

London

Dear Mihhael,

pleasure having you visit our school, and after
hearing your impromptu responses to our questions, I am more
confident that the large attendance the day before was in
anticipation of your participation. Also, my best wishes— for
the success of your new venture, Psychological Medicine yes,
I have subscribed, I trust in time for the "special offer".

It

was a

I am enclosing a number of additional (older) reprints
on the subject of EEG classification of psychoactive drugs,
as well as a pre—print of a report of an analysis of a new
compound. It has been my custom to review the various drug
classification schemes in my second lecture in a graduate
biological psychiatry seminar. Most published classifications
schemes do not fare weIL for their limitations exceed their

utility.

The neurophysiology scheme

is explicit

and

testable;

excellent quantification;
replication is feasible, limited only by time and expense.
I commend these techniques to your review.

modern techniques provide

and

Studies of the effects of drugs on sleep by T. Itil
(St. Louis), Ian Oswald (Edinburgh) and A. Kales (Los Angeles);
on evoked potentials by C. Shagass (Philadelphia); on contingent
negative variation by Dongier (Liege) provide parallel and
supporting evidence for consistent neurophysiological effects,
but the data of these studies is more recent, less complete and,
as yet, not well codified.
Again

my

thanks for your most interesting presentations.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

P.S.

Could you

address

if

the psychiatrist is in Kenya - and his
you have it. Do you know him personally?

tell

me who

my.—....;..w

“‘1‘ wm7ﬂw.n"r'.ﬁ—‘..

�</text>
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-—c,

v...

.mrﬂl—gg

.7"

q...

“7. .1.

October 26, 1970
Dr. James Inglis
Department of Psychology
Queen's University
Kingston, Ontario
CANADA

Dear Dr.

Inglis:

Thank you for your reprint, "Shock, Surgery and Cerebral
Asymmetry" which I read with interest, and enthusiasm except.
for your insensitivity in continuing to use the barbaric non"

descriptive term of "shoc ".
My associates have treated a few patients with multiple
induced convulsions using frontal electrode placements. While

induction is more difficult, it is practical, however, and
the results comparable to bitemporal and unilateral placements.’
We are now studying the memory, clinical and EEG effects in a
systematic way.
A preprint of our recent data is enclosed.
Again, many thanks.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

Time-v

�</text>
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                    <text>October 24, 1970
Dr.

641

Strah‘le-Vitz,
Stafford Street

3

o

McDo

Winnipeg 9, Manitoba
Dear Dr.

Strahilevitz.

Your letter to Dr. John Nurnberger requesting a research
or clinical/research position in psychiatry has been referred to me,
for the possibility of such a position in our laboratories. Dr. Nurnberger
was apparently impressed by the biological nature of your publications
and thought

that your interests might be served

by our programs.

The Division of Biological Psychiatry is the principal
research facility of a large community mental health center in New
York City. Our laboratories are dedicated to research in clinical
neurophysiology (quantitative electroencephalography), drugs,
drug abuse, and induced convulsions. Our populations are acute
psychotics stethe Metropolitan Hospital; depressives at Gracie
Square Hospital; chronic psychotics at Kirby State Hospital and
drug abuse subjects at Metropolitan Hospital. We are supported
by funds of NINE, New York State, ﬂew York City and private individuals.
We are responsible for psyciatric residency training in biological
psychiatry, psychopharmacology and research methodology. Some
recent reports are enclosed.

If such a clinical/ research program interests you, I
would be pleased to have the opportunity to discuss your appointment
with scientists of your naming at Galesburg and Ohio Statc-~ as I
know many

of the

staff at

both

institutions.

I look forward to hearing from you.
Sincerely yours,
Max

mf/

Fink, M.D.

Professor of Psychiatry

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um~-w&gt;mvms~s are-w.“ w-M ssh-w-

~..v

~u——.~

~-m4ﬂ~ nul‘amawr—

\

'Ilra'm

‘

an...

7,:

-

,wq,.maa--mxu.n

w-m‘wvﬂmn...».- &lt;,pn-

'If-rl'rr

tum:

October 23, 1970
Dr. Daniel X. Freedman

University of Chicago
Department of Psychiatry
950 E. 59th St.
Chicago,

Illinois

60537

Dear Den,

For many years, I have maintained an interest in ECT. When
unilateral ECT and MHECT were suggested as procedural modifications
which may improve the treatment process, we undertook a detailed
study focuased on the behavioral u neurophysiological inter"
relations. The data has been most consistent with the theories
of ECT based on Weinstein and Kahn'e studies. I am pleased to
submit this report for your consideration for publication in

the Archives.
Many

thanksfor your consideration.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt

enc .

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m7

V

~~

,

ya

«yr-wuuvvwnwmna

v

mnw‘? Maw-v: ~&gt;mmw&lt;-

mm

roan—pr“

‘v-Iww'r‘wawr-V“

.

,

,,.,

October 23, 1970
Dr. Allen Raskin
PRB~NIMH

5456 Wisconsin Avenue
Chevy Chase, Maryland

Dear Allen,

I very much enjoyed your presentation in New York on
Thursday, and I am writing to ask if you could make a copy of the
preprint available for my liesurely reading. If I understood the
text, the first study confirmed the Hillside findings except that

of the subclassifications which we found responsive to the
different drugs were blurred. The second study is a clear statement
of the limitations of the proposed antidepressants.
some

and ECT,

are in

?

Is there any consideration to a comparison of imipramine
or a more detailed study of ECT, now that these results

It is

a fine study and

my

congratulations.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
mf/

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~Vr.¢r7‘.wr~-

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m-

I, 7.. uns-

,,

»~,.

»

an

.v-u

v.

v

"w WHJJWTXHS'W‘Y'J".'I'3I1'Fl’,‘l'l‘ww‘7
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'

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"1'

«v

won

m— nmrz-wm—vc.

m

wm- '7' H'wmrl-UIT

October 23, 1970
Dear Mr. Glushein,
Many thanks for your kind invitation to meet with your
fellow alumni of Cornell Law School on Wednesday, December 16. I look
forward to discussing the drug abuse scene in New York with its
political overtones; the research projects, particularly in opiate
dependence and cannabis (marijuana); and some recent novel observations
which provide an optimistic View of the immediate future in one
type of addiction. As a title, you may select either

Immunization— A.Realistic Answer to Opiate Dependence

or,

Drug Abuse, 1971-1975.

I graduated from the New York University College of Medicine
in 1945, and completed post-graduate training and certification in
neurology (1952), psychoanalysis (1953) and psychiatry (1954). I was
the first Director of Research of Hillside Hospital in Glen Oaks. N.Y.
(1954—1962) and established the Missouri Institute of Psychiatry in
St. Louis in 1962. This 150 bed research facility is the principal
psychiatric research facility of the state. While there, I also
served as Research Professor at Washington University School of Medicine.
In 1966, I returned as Professor of Psychiatry at the ﬂew York Medical
College and Director of the Division of Biological Psychiatry. The
Drug Addiction Research Service of the Metropolitan Hospital Community
Mental Health Center has been my responsibility since 1967. I have
been a consultant to the National Institute of Mental Health, the
Food and Drug Administration and many pharmaceutical concerns, both
here and hhroad. Inresponse to support special psychiatric research
projects in unpOpular areas my friends and 1 established the International
Association for Psychiatric Research and I am its Executive Director.
I have published more than 150 scientific articles on drugs, brain
function, convulsive therapy and drug abuse.
Again,

my

thanks for your kind

invitation.
Sincerely yours,
Fink, M.D.
Professor 0‘ Psychiatry

Max

mf/

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N.

“amp“h warm “(Who «-

1'4 x»;.-..—.—..

.I‘Igm“*"1\'w'l“ﬁ\m

w--W&gt;'W§!‘P‘W‘wwmr\1wwwomﬁu‘wm‘m‘ﬁ'

,

w,

.

V

_

-_—,v~

October 23, 1970
Dr. John Nurnberger

Indiana University School of Meliciue
Indianapolis, Indiana

Dear John,
Dr. M. Strahilevitz to me.
have
I
his record of interest
I
written directly to him,
suggesting he indicate an interest in coming to our city. His
experience is in drug abuse, schizophrenia and EEG-- a good fit
to our programs I
found

Many

thanks for referring

Many

thanks.

and

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>October 23, 1970

Professor Stanley Grupp
Illinois State University
Normal,

Illinois

Dear Professor Grupp,
Our

strategy in studying marijuana users in

Greece

is

possible to do overseas
quite simple-~to answer the question, is it
We
?
man
in
plan to examine 60-80
studies of an experimental nature
the
and
extent of their
determine
known chronic hashish users
and
of
their drug
assay it; obtain neuroabuse; obtain samples
tests and
performance
physiological test data, psychological
and compare
damage;
measurable
brain
have
determine if the subjects
community.
from
their
of
matched
non—users
sample
this data with a
We are struggling with some of our test procedures in another
culture and by the problems of user identification (although we have
governmental cooperation, there is still a problem of user cooperation).
I trust this interests you.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry
(Project Director)

mf/

_

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                    <text>"Mm. aw ﬁw-yp'w

7:

rwa ‘nvxm'vgfv

—,.

r

:yoqlt’l

N‘w unv-gw—m

. w

Maura-V

ii.l'm"~'.~J-WVW.W“1§&amp; w-mr xu

—'Inv1,-s')W—‘¢1v

October 23, 1970
Dear Steve,

Enclosed is my reply to the population inquiry. In addition
to a classification by populations, phase of drug study emphasized,
perhaps a classification of special interests and services might
be useful, such as the units focussed on clinical toxicology,

international collaborative studies, ophthalmology

EEG.

Effective this month, Dr. Jovan

and EKG, and

Simeon has

staff of the Missouri Institute of Psychiatry

rejoined the

and he has been
replaced in my programs by Dr. Richard Abrams. Dr. Abrams has been
a research fellow for more than 2 years and has focussed on studies
of ECT, memory mechanisms and recently the treatment of alcoholism
with an alcohol antagonist and sch120phrenia with heavy metal
chelating agents. I would be pleased if he were placed on the ECDEU
mailing lists, at the above address.
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
mf/

gamma:
5 «was.
yams-» ﬂag ,

4%»:

vm

”WWW“

r~-1lerl'-RIZVI;IW'J

�</text>
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                    <text>October 23, 1970
m

,

”PU—WWV'VAH

Dr. Arthur Rifkin

Hillside Hospital
75~59 263rd Street

Glen Oaks, New York
Dear Dr. Rifkin:

wr&lt;rw-"trm~¢

‘rm'W'

"YMMV”."m‘m.

only published data are enclosed. The additional
data has been collected by Drs. Itil and Keskiner in St. Louis
and Polvan in Istanbul. My IND is nominally in Dr. Itil's
My

name now, and

you

I

am

I

have no data since 1967—68.

sending your

directly.

Good luck on your

.W..,;W-..Wr.w.r

and Hex Pollack.

letter to

Dr.

Itil,

interesting study.

asking him to answer
8y

best to

Sincerely yours,

"S.

mmwr-

Fink, M.D.
Professor of Psychiatry

Max

MP:kt
mw

cc: T.
enc.

Itil

Don

Klein

�</text>
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                    <text>‘:-'

mr'v-

y

".mumuwm

an

October 21, 1970

Philip

Dr.

Tannenbeum

Associate Director of Development
Smith Kline &amp; French Laboratories
1500 Spring Garden Street
Philadelphia, Pennsylvania 19101

Phil.

Dear

tie

Thank you for the opportunity to read the date on the
and trans forms of doxepin. I had thought there may be

distinguishing qualities which could justify our attempt
EEG discrimination. Lacking the basis for such a
distinction makes the study less interesting.
some

at

an

I am returning the data sheets for your
thanks.

files, with

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

‘

�</text>
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                    <text>,

.
arm."
4

,

wu-

w...,, a.

_

,

W4 W,
.

1 wan—v,

mmwrm“W my)”.qu W...
V

.

,

Dr. Roger Neyer

Boston University School of Medicine
Psychopharmacology Laboratory

Harrison

Boston, Massachusetts 02118
Dear Roger,

I

have read your two pre—prints with

interest,

and look

forward to the discussions in San Juan. I am left with a
question. Is a quantitative method for blood levels of
circulating THC available? Your suggestion of the use of
such a measure is based, if I understand the text, on the
need to assure the investigator of central effects of
cannabis, and to provide an independent quantitative estimate.
CNS

In addition to blood levels, have you considered direct

measures, as in quantitative
Thanks again

EEG?

for the preprints.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mfzkt

.

WWNWW

E

October 21, 1970

740

V" w ,

.

_

my"

�</text>
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                    <text>w.»

mwmu

-——m

nwmmmrtw‘vw-

“runs—"tum:

.—

Ayn-NV

Tmnn‘.»

October 21, 1970
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Wilma,

Enclosed is our "final“ report on the pilot 6? 41299 study,
and the Geigy ”Record of Treatment” forms for 12 patients. These

data are to replace our earlier interim reports.
We

anticipate the clinical

next month.

GP

41299 ~ placebo study, to

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

Mszt

start

�</text>
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                    <text>October 20, 1970
Dr. Avram Goldstein
Department of Pharmacology

Stanlbrd University School of Medicine
Stanford, California 94305
Dear Dr. Goldstein:
I found your article, "Urine Testing Schedules in Methadone
Maintenance Treatment of Heroin Addiction” of great interest, and
your analysis of the odds at finding opiates are clearly presented.
In our pregrams we have eschewed urinalyses because we have been
unable to find a satisfactory answer to the question: What is
to be done with the patient with a urine positive for morphine?
done

is your response to a ”positive” urine? Is urine testing
for research purposes, or for clinical, or both?

What

Again, congratulations on a thoughtful

article.

Sinceeely yours,
Max

Fink, H.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>w”

.rﬁvvrﬂ

1w maxv‘EWF: WW.

iv.

:—v.

,. ”a

w.» nv‘u‘c-

.

m.

.

,WV.
w

‘

.0”.

...-~.¢..,v.-

,"

,n‘.

t\a-'V~:‘

October 20, 1970
Mr. Robert L. Marlin

Sande: Pharmaceuticals
Hanover, New Jersey 07936
Dear Bob,

In response to your
We

letter of

10/15/70:

Our experienced with S 42,548 are summarized in our report.
anticipate an Opportunity to review this study, particularly

sinco the study did not

elicit

a conventionally useful

The study was done in male adult
academic populations.

volunteers, derived

Sincerely yours,
Fink, M.D.
s
Profossor of Psychiatry

Max

MF:kt

profile.
from

�</text>
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                    <text>lav

wv—mww

w.

---.-

w

,
r
V.

m

..,

A“

a-

”mum—gm“

October 19, 1970

v-aw-u—

uw—vmu

wmmvmg‘mwﬁ

.

Dr.

J.

New

Brﬁnswick 08903

Rutgers

R. Wittenborn
~ The State University

Dear Dick,
vu-rwvw

;~

v.-

.

“Fee

is pleased to submit
the following nominees for positions on the Executive Committee
and the Council of the ACNP for 1971:
The Nominating Committee of

the

ACNP

v.

,
_,.v.,

v_..,,

v..-

T‘lx"‘"';'tw

-

,J.
A,

President
Pres.~Elect
Vice Pres.
Sec.~Treas.
Asst. Sec.~Treas.

Joseph Zubin, Ph.D.
Alfred M. Freedman, H.D.

Councillors

Daniel Freedman, M.D. ex 066£c£0
Enoch Callaway, N.D.
(1971)
Morris Lipton, M.D.,Ph.D. (1971)
(1972)
Sidney Malitz, M.D.
Charles Shagass, M.D. (1973)
(1973)
John Burns, Ph.D.

m

'WJWTW'JWW

gnu,"

Arnold Friedhoff, N.D.
Richard Wittenborn, Ph.D.
Daniel Efﬂbn, Ph.D.

w

I have taken the liberty of discussing the nomination of
Asst. Sec.—Treas. and Pres. Elect with the nominees and have
received their willingness to serve, if elected. I have not
canvassed the other nominees but will do so if it is customary.
I

am

indebted to the fellow

Itil,

members

of the Nominating Committee -

George Simpson and Larry Stein ~
patience and cooperation in making these selections.

Wayne Evans, Turan

for their

vm-‘ny-e—

�~

nun

“~lI--V.‘»'\:'

---—1

v-v

-':_~v‘0'"

YVVv-gw."4..

Fl)

Dr.

.
. m..p. u. w...
.
,» . .«.r.
.~-.,»-..v-.‘.,y‘mvw-§Mm;nwm.nv
..v‘..
”re-«s. «at.
..._ u m”,
“x. .,,
farm&lt; ,.~._w tv.‘x-‘«T-'
(

,

J.

R. Wittenborn

,

»

¢"‘nrtxwv “1,..173vyrum

-.,V,.,;-

w,

f.\,-'u»' ew- '.»i"IVe-,"'-5;vvrr/.~,u—wa.p‘

Hr."

by the number of replies ~ seventeen.
in making these nominations.

The

suggestions were very useful

Sincerely yours,
Max

rimT

PKF:Izt

my-wrv-w

'7.».

17'"-

www-

a.“

u-u-w

m
‘H'

M.D.

Nominating Committee

»

«mumwwa-nwwrnu

Finkk

Chairman

v-v

.

October 19, 1970

~2~

In canvassing the membership for nominees I have been delighted

w

-»

,

,

M.“

m

a.

‘

.

.{r‘

H

�</text>
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                    <text>‘:«:'W (F.

October 17, 1970
Dr. John Tamerin

Mount Sinai School of Medicine
106 Street and Fifth Avenue
New

York City

Dear John,

I would be pleased to participate in a seminar on research
methodology for the advanced residents in the Department of Psychiatry,
and could participate in December or January. Best is to call me
any afternoon at 369-7900 x246,248 to confirm a date.

active

There are three diverse subjects in which we are now
for your staff interest. I will send

and you should pick one

the appropriate reprints.

longest study period has been dedicated to the
problem of measuring the changes in brain function associated with
treatments of mental illness; the development of the digital computer
techniques wlich can be seen at 5 East 162 Street; and the application
to the evaluation of new drugs. This is an advanced subjevt, somewhat
esoteric, but of high intellectual interest.
The

is the evaluation of ECT and the development of
its mode of action. The recent studies are
dedicated to the interrelations of electrode location, memory,
clinical effects and changes in brain function measures. This is the
most relevant to clinical practice and the most practical.
The third is the use of narcotic antagonists in the
treatment and prevention of opiate dependence. The clinical and laboratory studies are interesting, but less basic than the other
Another

an understanding of

two subjects. Our views on this treatment, methadone and the
psychotherapies are most controversial.

Thanks again

for the ihvitation.
Sincerely yours,
Max

mf/

Fink,

M.D.

Professor of Psychiatry

rc—

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                    <text>October 17, 1970
Dr. S. K. Vanov
Upjohn Company
Kalamazoo, Michigan
Dear Dr. Vanov,

I have read all the comments on the 1572 and the protocol
U~28,774 and find them acceptable, except the protocol change
page 6, marked " item 10. added.“ What is added ? I cannot
recall the exact nature of the conversation, and would appreciate

for
for

clarification.

supplies arrived and the study will begin immediately.
May I suggest that you correct your files as to my address
Your letter was addressed to the Department of Psychiatry, 1901 First
Avenue, New York, 10029. while this address 15 correct, it requires
at least one extra week, and I would suggest that you use the address
above (5 East 102 Street) for more rapid delivery.
The

many thanks

for your review.
Sincerely yours,
Max Fink. , vs. 1).

Professor of Psychiatry

mf/

?

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Vamwom.»

-

w

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«w.

WW

October 16, 1970
Br. qudos
Boston State Hospital
Boston, Massachusotts 02129
Dear Dr. Gordos:

is a note to George Zwilling regarding the technical
aspects of the analysis of your recordings. The data is of good
Quality and we have paper and card outputs for each record. He
will be able to complete processing of this data in accordance with
roquoats made in the note to Mr.,Zw1111ng.
Enclosed

would be pleased to analyze the records as each tape is
collected, so that we can have the data available when you wish
to review it. If you wish to have tho analyzed records sent to
you before the study is completed, we will arrange
we

it.

Sinccrely yours,
Max

Fink, M.D.

Professor of Psychiatry
HF:kt

cc: J. 0. Cole

�</text>
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"wa. w an.“

'

AMWI-

»..

x

'Pf‘."4"x~»."-l-'l' amour-m

,_ ».v-- wmw- , ,Iavx“'_w~1"~w-.. we:van-:r-y-y-V-wnw-nuz-v aursw‘I‘IWJWWJ-"rﬂr

mama-aw,«.7'.1—'“v»\‘ wwa......n..,., e.

October 15, 1970
Dr. Herman C. B. Denber

Director of Psychiatric Research
Manhattan State Hospital

Ward's Island
New York, New York 10035
Dear Hi,

This paper I presented in Istanbul was a summary of my
work with Turan and Dr. Polvan (published) and subsequent
studies by Turan, All Keskiner and Polvan. I do not think that
I can publish this material, but thank you for the invitation

joint

nevertheless.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

H?:kt

N

,7 -

,

[.4 V.

,ugﬂ

“,7

.

.

.

a, H,”

._

�</text>
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