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                    <text>w—p.

..

“my—(”rm (y..—

.V‘n-v—‘~"

wuvwnnw-mv'm-n—;mvu"‘m--tm.

. I-r'u,‘

ww.’ ‘1 “W1”...-w-¢m_v_.__,,“w"; "—7,.” n— ‘1”.‘Fwn—n

July

1m,

www
_

22 , 1970

Dr. Louis S. Harris
Department of Pharmacology

University of North Carolina
School of medicine
Swing Building
Chapel Hill, North Carolina 27514
Dear Lou,

Enclosed

is our

You know

that the

check as reimbursement for expenses

the June 4 meeting on narcotic antagonists.
appreciate your participating.
published in §gienge,

summary

I very much

for

of the proceedings are to be

sure you heard that Endo (PuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility“,
called DuPont and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

am

—

My

best regards for

a pleasant summer.

Sincerely yours,
Max

Fink, M.ﬁ.

Professor of 9sychiatry

MP

:kt

enc.

�</text>
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                    <text>v.
—,

A,

,—

wmyv

July 21,

1970

Mr. G. G. DcAngelis

Director, Special Communications
Pfizer Pharmaceuticals
235 East 42nd Street

New

York,

York 10017

New

Dear Er. DeAngelis:

for your letter of July 14. Cepies of the face
curriculum vitae are enclosed.

Thank you

sheets of

my

For announcements, the proper designations

are:

Dr. Max Fink, MA).

Professor of Psychiatry and

Director, Division of Biological Psychiatry

Department of Psychiatry
York Medical College.

New

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>July 21,

1970

Dr. William R. Wartin

Chief,

MIME

Addittion Research Center

P. O. Box 2000
Lexington, Kentucky 40501
Dear

Bill,

release form of antagonist is
13
of
clear.
letter July describes some steps which may
be necessary to test the feasibility of Sr. Yolles’ preparation.
The need

Your

for

a sustained

Al Freedman is in Europe and I am leaving on August 4.
and I will both be together again in ﬂew York after September 3
and I would suggest that we arrange to meet - with Dr. Yolles and
any other interested participants ~ during the second or third week
in September. This can best be arranged on our return.

He

you are aware that Endo Laboratories on
announced
decision to discontinue supplies of naloxone
a
July
for clinical trials. In re5ponse to inquiries from friends on
the New fork ftmes and CBSeTV, Dupont reversed their decision
and our clinical programs, despite the improhanility of its
success, will continue. A copy of “r. Serchuck‘s letter is

Incidentally,

3

enclosed for your interest.
My

best regards.
Sincerely yours,
Wax

Fink,

M.D.

Professor of Psychiatry

MF:kt
811C.

�</text>
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                    <text>way-v.1

ww—u-

.m..,..«.—,.-...

..,

."w

"1w,“

__

&lt;

July 21,

1970

Dr. Albert Kurland
Spring Grove State Hospital
Baltimore, Maryland
Dear Al,

efforts at reversing the policies of Endo Laboratories
have been successful. Enclosed is a copy of a letter which I
received from Mr. Serchuck confirming this change.
Our

Having survived this crisis, I do believe that it may be
useful for us to continue our informal communication so that
we can be prepared to deal as effectively with future reversals.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>July

21 , 1970

Mr. Joseph Lelyveld
New York Times
New York, New York

Dear Joe,

this opportunity to express my personal
thanks for your assistance and efforts in reversing policies
of Endo Laboratories in the production of naloxone. Your
inquiries served to alert DuPont to the public health importance
of this project in a way that we could not accomplish.
I want to take

vp.-v-r"-V

v-

WW.“

wry-7*

n

p,“

Enclosed is a copy of a letter I received from Mr. Jerome
Serchuck of Endo Laboratories, confirming that they will supply
naloxone for the next phase of the clinical studies.
My

thanks for your fine

article

and your

assistance.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
811C .

....Y

‘.
.

~

-;.

.v-«m

“n"r'L-ur'CSQ‘IF'YI

)axwzmlmrvnnv

I"

,.
r'J'FI'!

writ-9‘

FWI‘Wﬂ'ﬂr—vz“

�</text>
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                    <text>-

.1

'1,

--..n—~A,~....«

mr-Ww-Vwam—rn

ransom

”2:15"

"rw

July 21,

'w'r

.1“:

1970

Mr. Jerome Serchuck, Vice Pres.
Bndo Laboratories, Inc.
1000 Stewart Avenue
Garden City, New York 11530

DW-a'ﬁzuﬁm

mn'r'rrnpum

or“,

Dear Mr. Serchuck:

TJ‘J'SW

Both A1 Freedman and I thank you for your prompt reply and
favorable consideration of our request to continue supplies of
naloxone for clinical trial in the treatment of opiate dependence.
The proposed supply

of

6

kilograms of naloxone,

3

kilograms

by November 1, 1970 and 1 1/2 kilograms each by December 1, 1970
and January 1, 1971 is satisfactory and will permit us to undertake

our present

clinical assay.

We have discussed with Dr. Jacobson the formulation of naloxone
and he has assured us of his coeperation in providing the supplies in
either tablets or liquid vehicle, as most feasible for the study.

On behalf of the College and the New York State Narcotic
Addiction Control Commission we are indeed grateful that you are
considering supplying this at no direct cost to the people of the

State of
on

.

New

York.

My personal thanks for your cooperation
behalf of this program.

and sincere

Sincerely yours,
mawr{mm.xrw.w

Max

Fink, M.D.

Professor of Psychiatry

“1r-":w=-vmmmvzwm'“wf’w

'1'":

‘W

WWW)?”

we

m
‘

MF:kt

efforts

�</text>
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                  <elementText elementTextId="105927">
                    <text>July 22,

1970

Dr. Joseph Cochin
Boston University School of Medicine
Department of Pharmacology and

Experimental Therapeutics

80 East Concord

Street

Boston, Massachusetts 02113

Dear Joe,

Enclosed

is our

check as reimbursement

for expenses for

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.

thet the
in
published
§c§g§gg.‘
You know

summary

much

of the proceedings are to be
’

Also, I am sure you heard that ﬁnds (ouront) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility”,
called DuPont and within the Week the edict was rescinded.
Supplies are assured for 1 year was reported-by the New York
Times (July 14).
—

~

My

best regards for

a pleasant summer.

Sincerely yours,
Max

Fink, ”.3.

ProfesSOr of Psychiatry

MP

:kt

one.

�</text>
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                    <text>w. ‘—

July 21,

_,

.-.,

1970

..

Mr.

.‘nVr

am

up,"
.

an

m.—

o
v

Earl Ubell

CBS-TV

51 West 52nd

New

York,

New

Street
York

1:11-‘wwv-p

.

.

e

w.

u

Dear

‘
.

mm,

'
WW

*V"
—w

”Hr-m

Earl,
I want to personally thank you

W»

for your assistance

and

advice in continuing the study programs of naloxone in the
treatment of opiate dependence. Your suggestions were most
helpful and your inquiries at DuPont served to communicate
to that organization the public importance of this program.

pleased to enclose a copy of the letter I received
today from Mr. Jerome Serchuck of Endo confirming the reversal
of their decision and their continued support of this program.
I am

"MM.IWHV'II

"an".

un-unlr-Rlv‘m,

,1",

Incidentally, I watched the first installment of your
new series on drugs. It was well done and I hape that the
one. I
rest of the series comes across as well as the first
kind
refer~
the
thank
for
indeed
you
am embarrassed, but must
ence to

My

,‘qu’wr'ewﬁ-ﬁ

my

participation.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszt
enc.

�</text>
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                    <text>5*:

July 17,

1970

Dr. Ivan K. Goldberg
New York City
Dear Dr. Goldberg,
1....-

.r.

qua...

Thank you for your kind invitation to participate
in the development of the Behavioral Science Library. I regret that
my present commitments already overwheim me, and I would not be able
to give the project the attention it deserves.

W.«Wm~.w.——r..~r_.wn-”

—.-:vaw‘.w

May

I suggest that other

members

of this Department

be in a better position to contribute, especially Drs. Arthur
lake and Richard Resnick, on the subjects of treatment of opiate
dependence by narcotic antagonists; Dr. Jovan Simeon on the treatment
of outpatients with psychotropic drugs, and the special problems
of the use of drugs in adolescent behavior disorders; and Dr.
Richard Abrams on the comparisons and applications of unilateral
and bilateral convulsive therapies in the treatment of depressions.

may

Good luck

u-memee.w-ww

!

Sincerely yours,
.u.

Max

‘m-mw—mmr—

Fink, M.D.

Professor of Psychiatry

mf/

.—D

‘i

�</text>
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.wv W

T

.V.

..

.,

July 17, 1970
Dr. Allen P. Borger, M.D.

Dept. Clinical Research

Pfizer

&amp;

Co.

Groton, Connecticut 06340
Dear Allen,

of

Doxepin,

7/15/70.

a draft protocol for the EEG Profile Analysis
Comparison of Pamoata and I101 Fomulationo, dated

Enclosed

III:

is

In reading the initial human data, it seems that the
reduces
the rate of absorption, and we are projecting an
pamoate
extension of the duration of each drug experience to 3 hours, rather
than the 2 hours we found sufficient for oral doxepin (3C1).

the time you read this, I will have tried to reach
meet on Wednesday afternoon, if possible; or
you to ask that
another afternoon later in the week.
By

we

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>rw—wn.vs“

'w—u

-wrb~w‘wwxvv'wm¢iwrwmg

_

,»

,

_

,

"an”

“.7 ., .7..,......w..,.

.-- p. “cw-wuu.

mmy

~V‘W-

_‘—.—_—m—Wr_c~m

7...“...

,. m...

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..

van-«w

I-Imwﬁw

Fe

ww-

.m

Fwy-,1.”

y...

v-

....~&lt;~

1

ayw_,'11-vL—W‘ﬁ'vawrw

.1-

nrﬁyrrnv-“WWJWH

July 17,

1970

Miss Eileen Milling
PRA

210 East 47

ﬂew
Wamvwmmrmmwrmmwrwwr

Street

York City 10017

Dear Miss Milling,

In response to your request, enclosed is a summary
of a special meeting, convened on June 4, 1970, to review the
available data on the use of Narcotic Antagonists in Opiate Dependence.
-'.'"{&gt;".2

rg—mem

y.

:

E

-

of this ﬁepartment is under the personal
M. Freedman. He is Professor
of Fsychiatry and has been chairman since 1960. He has supervised
a narcotic addiction treatment and research program in the Department
since 1961.
The work

direction of the

Chairman, Alfred

I joineddthe program in 1966, and am Professor of Psychiatry,
and Director of the Division of Biological Psychiatry.
we

have accommodated requests such’as yours, making

available the resources of our center as the project may require. In
each instance, particularly with profitnmaking concerns,or agencies
operating under reimbursement contracts, our fees are negotiated in
advance. I would be pleased to discuss your program with you before
August 1, or you may wish to negotiate with the chairman after September
1.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.
.

mf/

.

�</text>
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                    <text>H,

..

u

Wyn-Kw.‘

July 17, 1970
Mr. John

Director,

Ingersoll
BNDD

Department of Justice
Washington, D.C.
Dear Mr.

Ingersoll,

For more than four years, we have been using
diecetylmorphine (heroin) in our studies of the role of narcotic
antagonists in the treatment of opiate dependence. Because of
existing regulations, we have received our supplies from the
Department of Justice on an informal bases.

requested an additional 10 grams of
were assured that our request would be
recrystallized heroin.
filled. It has not been to date.
In March,

'wrrm-nwww‘"

We

supplies for study purposes is exhausted, and
I am writing to request 10 grams of recrystallized heroin for research
purposes—- purposes which are in the national health interest. This
work is supported by funds of the New York State Narcotic Addiction
Control Commission, the national Institute of Mental Health, etc.
.

“

we

Qur

Thank you.
"WW-Um"

Sincerely yours,

v
3,
"2w,

um

v

Max

mf/
av

'VEI-rv

,

Fink,

M.D.

Professor of Psychiatry

-~m&lt;~»:awwvwwrjrmrmw&lt;

�</text>
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                    <text>July 17,
Ampex

1970

Corporation

Hackensack,

New

Jersey

Gentlemen:

Please repair the enclosed amplifier for
Serial #15l728, Cat. lOO5lZ~080.

Bill:

SP-SOO,

Fink. M.D.
Department of Psychiatry
New York Medical College
5 East lOan Street
Max

New

York,

New

York l0029

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MFtkt

�</text>
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July 17,

1070

Dr; Charies Shagass

Eastern Pennsyivania Psychiatric Institute
Henry Avenue and ﬁbbottsford Road

Phiiadeiphia, Pennsyivania
Dear

Charlie,

EncloSed is a copy of the appiication for a
study in Greece as submitted on August 12, 1959.
pleased if you would assist us.
I look forward

hopefully, Greece.

feasibiiity

I would be

to seeino you in Prague, Istanbui, and
Sincerely yours.
Max

Fink, “.9.

Professor of Psychiatry

MFtkt
enc .

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nv-xnm-r-v

.
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',;r-vv-v&lt;

mun-

.:

,w»vr;«rxmavrram

July 17,

:x-u

w

1970

Dr. E. N. Terry, M.D.

Medical Director

Pharma—Research Canada, Ltd.

Montreal, P.Q.

Dear Dr. Terry,

I have received and read with interest the descriptions
of PR—F—36-Cl, Ko 1313, and Ko 1366. The laboratory data describes
these compounds to have significant adrenergic blocking activity.
The evidence for central nervous system activity is slim, and it
would be of great interest to investigate compounds of this activity.
We are now studying propranolol and will
begin a study of PCPA

this

summer.

The brochures lack and reports of single triils in
these been done ? If so, may I have an opportunity to
review the single dose behavioral and laboratory data ?

man. Have

reports,

Thank you for the opportunity of reading these
and I look forward to discussing them in greater detail.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

mf/

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                    <text>...

”curvy;

mum-m

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.

n.

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w

&lt;

m

,_.. I'tﬁf&lt;'lw—)"¢ up

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.

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w"... .‘wpnr... ._..

v...

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=7

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.

....

v

July 16, 1970
Dr. Allen P. Berger
Chas.

Pfizer

&amp;

Co.

Groton, Connecticut
Dear Allen,
A

Enclosed is a corrected version of the cidoxcpin study.
small addition was made on page four.

I find that Dr. chtanaga will be able to start the study
in August 1‘ the supplies are available now. we have asked for
10 mg capsulca, and matching placebo. tau you make 1000 of
each cvailable?
Sincerely yours,
.
at
'v
"or.

"r“,

Fink, 14.1).
Professor of Psychiatry

Max

r-wrr

""1

MP:kt
one a

MM;

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5.5,;

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.

.. ,

�</text>
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                    <text>July 16, 197°
Dr. Lois Chatham

National Institute of Mantel Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015

Dear Dr. Chatham:
Dr. Freedman and I have reviewed the Narcotic Addict
Reporting program forms, and believe that our participation
in such a record keeping activity wotld be useful.
How

many

in participation established?
thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
..

.w

awn)V'-'.‘r~""_"-w;“wr‘.-rﬁv&gt;

o

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WW.

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37.

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                    <text>July 16, 1970
Dr. Everett Elliuwood

Duke University Medical Center
Durham, North Carolina

Dear

Everett,

It was kind of you to invite me to contribute to the
volume on amphetamine abuser I would like to do so, but would be
unable to give the project any time until after the trip to Europe.
If you mean for the fall, I will do my best. If sooner, you may
wish to ahk one of the others.
I trust I will see

you

in Prague.
Sincerely yours,
Fink, M.D.
Profsessor of Psychiatry

Max

mf/

�</text>
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                    <text>July

16 , 1970

The Honorable William G. Milliken
Governor of Michigan

State Capitol Building
Lansing, Michigan

Dear Governor Millikan:

I am writing at the suggestion of Mrs. Donald A. Blonquist,
869 Canterbury Road, Grosse Pointe Woods, Michigan 48236, who
asked that we
you of our experiences with naloxone.

tell

met

Scientists experienced in the treatment of opiate addiction

at the

New

York Academy of Medicine on June 4.

They concluded

that narcotic antagonists, particularly naloxone, was the most
interesting new treatment of opiate dependence. They suggested
a number of lines of investigation ~ including the development of
a long acting form and additional clinical trials. A summary of
the proceedings of that meeting is enclosed.
Unfortunately, naloxone is produced by a small division of
On July 8 they indicated that their support of naloxone
would
research
cease because the promise of naloxone was so high
that they feared that they would be unable to meet the public

DuPont.

demand.

a reported of the New York Times called DuPont, they
became sufficiently concerned to temporarily resound their decision
and indicated that they would make supplies availible only to the
When

present three clinical investigators.

I trust that this information is useful to you.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkt

enc.
cc: Mrs. Blomquiat

�</text>
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                    <text>it
mm:

“‘Jrﬂﬂ'

July 15, 1970
Dr. Michael Taylor

Oakland, California
Dear Mickey,
Thank you for your letter of 24 June. I do understand
reluctance
to join the V.A. My recommendation was based on the
your
of
the
next few years~» shortages of funds, etc. —~ and the
realities
awareness that the V.A., being a lumbering giant, will change slowly.
It will provide funds and space and patients.
'

relationship to Kirby is progressing very
in
(Irv and I wrote it) and Dick
is
negotiation
contract
I visited Kirby today. The Metropolitan wards are understaffed

well.
and

The

However, our

but there are patiente,space and we will have the reaponiihility for
their care. I am sure we can work something out there within the
next few months.*
The report on lactate still stimulates interest. Our
idea of using the lactate test as an index of anti-anxiety drug
effect is now under trial at Pfizer laboratories. They are setting
up an experimental unit in a prison in Connecticut and will try
the experiment there. They are also planning to use our system to
analyze their EEG records. I suggested they not try their own compound
alone, but compare it to an accepted standard.
Have fun

in California.
Sincerely yours,
Max

Fink, N.D.

mf/

will have a position and salary, commensurate with
your experience, at either Kirby or MBCMHC. We will work out the
details in the winter. (Salaries are changing so rapidly, and the
structure at Kirby and at HHCMHC are too diffuse to make a firm
offer now-~ but I am sure we will find a basis for your continued study here.

* Assume

that

we

�</text>
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                    <text>July 14, 1970
Dr. Thomas Williams

Clinical Research Branch,

Room 10Al9

National Institute of mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear Tom,

I visited Martin Kat: late last month, he told me that
Con~
you were returning to head the section on depression studies.
success!
wishes
for
and
best
your
my
gratulstions,
When

studies of ECT are progressing well. We have completed
the first study, s comparison of unilateral and bilateral HOT,
and found that unilateral electrode placement provides less
memory loss, less EEG abnormality (with non-dominant accentustion)
but, alas, less clinical ”improvement" as well. The data supports
Our

our

ECT

hypothesis of 1961 and 1966.

have begun MMECT, and in our pilot studies, confirmed the
only for unilateral electrode
feasibility of the techniques, not We
well.
are monitoring oxygenation with
placement, but bilateral as
EEG
during the seizure.
and
continuously
the
ear lobe oximetry
We have improved our techniques so that we are ready to undertake
a more definitive study in the fall.
We

,

._

..

“s
".1

.
,__._

.
:5,

"My“,

,4

-ms-Wu;.n.,-.,,

w-

“W‘FI-‘m-‘mem

discussed, there have continued to be some problems
in patient control at Gracie Square Hospital endows are now
negotiating for beds at Kirby Hospital (division of Manhattan
As we

State Hospital). This issue should be clarified by mid-September.
We have also begun some CSF collections and measurements,
collaborating with Alex Ksroznar of Loyola University, who is
willing to do the neurohumoral assays.
I am writing, however, not only to give you a progress report,
but to suggest that the time may be appropriate to call a meeting
of the scientists working in ROI and in memory, to review the
impact that unilateral electrode placement has on our understanding
of brain function, memory and behavior. My associates would
like to organize such a meeting, and would like your collaboration.
The meeting would
A tentative list of participants is attached.
and multiple ECT and memory mechanisms, with
from
chemistry and neurophysiology. The questions
contributions
of memory functions and the impact
localization
of concern: the

focus on

unilateral

of seizures, repeated or single; the possible alternate routes
of behavioral change with less memory impairment; and, the biochemistry
of seizures and their relation to memory mechanisms.

�‘-

era-czar?“

rr

Dr. Williams

-2-

July 14, 1970

Such a meeting could be held independently or in conjunction with
another society, as the Aspen Brain Research series (held in January).
We would be willing to contribute
substantially to financing the
meeting. It may be possible to generate an interesting volume on
ECT

in such a meeting.

martin suggested I send you these thoughts. As I will be away
would like to invite you to visit us in early September,
to discuss this meeting and to review our ECT program.

in August, I
Again,

my

congratulations on your

new

mission.

My

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc: Dr. Katz
J. Shields
enc.

best regards.

�</text>
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                    <text>July 16, 1970
Miss Deveede Ross

c/o

New

England Medical Center

171 Harrison

Boston, Hessachusetts 02111
Dear Miss Kass:

I have reread your letter of July 2, and in the light of
your illness I would like to recommend the following.

3"
‘
-'

I have reviewed the combination of sick time, vacation
of 17 days, and overtime due you and find that your first day
of work is September 8, Tuesday, the day after Labor Day.

.

“v

Inn-:uvw"

5
1m

In the event that you decide to start your schooling I suggest
that you call my office at least a week ehedd of time.

‘3‘

'm-wmwvnu

I trust that you will be
work
to
on September 8.

V"
1‘»

7.

'/~‘M~'W1&gt;'s“m"",'h

sufficiently recovered to return
Sincerely yours,

J.»

,.,~;

,y;.-

Fink, M.D.
Professor of Psychiatry

Max

w],

.

en...”

~’
:20:

's"-'.?=

"Maintain,"

emvnr'Wv—m-Lv

~'

"-wwmmrw-vmru

Tm;

?

�</text>
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                    <text>July 14 , 1970
Dr. Marvin Perkins

Chairman, Planning Committee
Third National Conference Methadone Treatment
National Association for the Prevention of
Addiction to Narcotics
250 West 57th Street
York, New York 10019

New

Dear Dr. Perkins:
Dr. Freedman has left for his holidays, but before leaving,
asked that I communicate our suggestions for the Third Methadone
Treatment program.

duration of action and means of extending methadone's
useful topic. Comparisons with other treatments,
the
narcotic antagonists, would provide an appropriate
particularly
Tho data on
may be a

action

contrast.

Sincerely yours,
Fink, M.D.
Professor of ?sychiatry
Max

Mszt

�</text>
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                    <text>“(v-e-«nww-l

July 13, 1970
Dr. Richard Rech
Department of Pharmacology
Dartmouth Medical School
Hanover, Raw Hampshire 03755

Dear Dr. Roch,

In Aspen this year, Fred Brunet suggested that a session on
and drugs be organised for 1971. I believe I was supposed
to send you some saterial, and some recent reprints are enclosed.

EEG

Sorry for the delay.
From

active

the point of View of human psychopharmacology, the most
is being done by the following:

work

C. Shagass

I. Itil

A. Kales
C. Pfeiffer

—

-

~

Evoked responses

Sleep EEG
Sleep EEG
Amplitude Integration

Recently, I have become interested in the effects of unilateral
on the EC! process, and we have
observed differential EEG effects which are closely related to changes
in visual or auditory memory tasks. .This type of study, in animals
and nan may also be of interest to the participants of the Aspen
and

bilateral electrode placement

sessions.

Is there anything that needs doing in September/October? [I
away in August.]

will be
My

best regards.
Sincerely yours,

5

Fink, H.D.
Professor of Psychiatry

wnwr:

Max

mam-nu:

r
.-

w-v..-e~

Mr:kt

,v

cc: Dr. F. Brunet
BBC e

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                    <text>July 13, 1970
Dr. Msaaaki Karo

National Institute of Mental Health
1—7~3

Koonodai

Ichikawa City
Chiba-Ken, Japan

Dear Dr. Kata:

Dr. Henry Brill kindly sent me the curriculum vitae of
Dr. Shires Miura. I note with interest that he has extensive
EEG

experience, particularly for research purposes, in implanted

electrodes in cats.

We would be pleased to have Dr. Miura visit our laboratories,
and would give him the opportunity to meet our investigators, who
can discuss their work. Our focus this year is in the quantitative

assessment of

EEG

changes following heroin, methadone, cannabis

and various psychoactive drugs.

Our methods

are primarily period

analysis, using a digital computer analytic system.

We have no facilities for animal studies, and suggest that
Dr. Mints could obtain a profitable experience with Dre. W. Martin
(Lexington), Khazan (Mt. Sinai, N.Y.) or Collins (Upjohn Co., Kalamazoo,
Mich.) - each of whom is doing detailed animal studies.

Unfortunately, Dr. Miura is applying late for a fellowship
and space are already allocated until
the academic year 1972~l973.

for 1971-1972, as our funds

I also plan to attend the meetings in Michigan in 1970 and would
be pleased to discuss our studies at that time.
Sincerely yours,
I‘m Fink, 14.0.

Professor of Psychiatry

M?:kt

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                    <text>Iv:'-IV\raax‘.-VI7'

ma "fair."

u. v.-

v,

'I‘h‘ ..._

“qwmv

.3.

,w aw”-

-.

{levymvhwwynwg—‘m".»m~.‘l-; Inl'l’.!'l""~

;-

,.

wz-wnr

,

'w-w v wow-wr-

wan»,

‘Vv-

“y‘awam-‘wmwnna—wm)‘V‘fdlmi‘ﬂswan-I-xev'n'm m—~,~rv..vu-ww.mm—v—

&lt;

u.

.

July 13, 1970
,7..,‘,,..,____‘._..r—.4i-

Dr. Henry

Brill

Pilgrim State Hospital

Box 22

West Brentwood, New York 11717

Dear Henry,
This week we received a contract to collaborate with Dr. Miran
A1 and I are planning to he in Athens in mid-August
to arrange the details of the study which will be carried out

in Athens.

this fall.

I deeply appreciate your suggesting this study and your
recommendations, which assisted us in the negotiations.
Our studies of cannabis are progressing well. and as soon as
the reports are written, I will send copies to you.

_

§

i

I would also like to tell you of an unfortunate development
in the studies of naloxone. The June 4 nesting on antagonists.
concluded with an optimistic view that antagonists represented a
meaningful approach to opiate treatment. This week we were notified
by Mr. J. Conlon, Vice President of DuPont and the new leader of
Endo Laboratories, that they were notlonger supporting clinical
studies - neither provide naloxone nor allow the use of the IND.
We have asked to buy naloxone for further trials, but Mr. Conlon
has indicated the request cannot be net. They say the basis for
their decision is the expense of naloxone production; the extremely

;
!

limited world supply of the precursor, thebaine; and the probability
that when the clinical trials are successful, the demand would
rapidly outstrip the supply.
I have reviewed the c.v. of Dr. Shires Hints and have answered
Dr. Karo directly. Unfortunately, both space and funds are limited
for the coming year, until our new facilities are equipped and
funded. In reading Dr. Miura's history, I note his experience
in animal neurophysiology which may be useful to those investigators
with on-going animal studies as Khaaan, weeks, Vikler and Martin.
we would entertain his visit to our laboratory to become acquainted
with our methods.

�-2-

Dr. 3:111

Again.

in Grace...

:1

that:

for your

July 13, 1970

”statue. in «twitching a
“unruly your: ,
Mu:

Pink,

11.1).

Profuoor of Pcychiutry

)4?th

study

�</text>
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                    <text>rs—nynmvuw

Tuﬂm‘wwtﬁnwrx’u‘«WV-K14W‘m‘f'1m'ﬂ't‘W-Wlm

i

,

nul»w.
‘

-

,

mr

u— u

.
up“ r,‘rw

s—an,

r
.

“wag—.WWMv.»

w-

July 11, 1970

Peter Halasz
Budapest, Hungary

Dr.

Dear Dr. Halasz,
Dr. Volavka and I have reviewed your

credentials. I plan to

be in Prague

August 10 to 15, and am staying

If

letter

and

at the C.I.N.P. meetings

from

at the Parkhotel.

you can arrange to attend the meetings,

us an opportunity to discuss the programs of

it will

this Department.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

give

_

7,

”rm”,

»

--:v»-,_ hvaJI-"m‘ldrgwu

,2

�</text>
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                    <text>"wamw

\\

‘gv-I-

‘w

wwwmmwvv

-

~

July 10, 1970

‘

Dr. Leah Lehrer

Consultant, Hospital Programs
City of New York
Department of Hospitals
125 Worth

New

York,

Street

New

York 10013

Dear Dr. Lehrer:

for your inquiry of 7/3/70. Enclosed are the
three protocols you requested, and I trust these are sufficiently
descriptive.
I have called our Research Administration, and Mrs. Lasker's
response is attached for your information. Perhaps Mr. Constantine
can be instructed to send the material as complete as submitted, and
Thank you

more promptly.

Sincerely yours,
;

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

encs.

�"Tu-w ' 'M-w-

V

~—-w—r~ Vwa’avw~—

u...

»»-Ar~"~wi\-

V'HDWMﬁ'Tﬂ/ﬂ'tilwuy ,«vgg-g-u-r. “-7.; vlq‘p'wﬂ

'nr‘wu' »

.imvm-‘m—~...,,...,..(&lt;.--~—.r- Wlﬁ\\_u--ﬂW-qr‘ "4...“.

July 10,

,w.........e.,,.w..,

..

‘3”.‘v‘m ”Wm".

...~

i»...

1970

Mr. John Thompson

Bristol Laboratories
Syracuse,

New

York

Dear Mr. Thompson,

For a number of years we have supported the development
digital computer analytic system for EEG analysis, using an
IBM 1800 central processor. Our programs are of two kinds-- period
analysis and power spectral density. These run in real time and our
outputs allow for a variety of statistical techniques. Our present
approach is to determine drug effects by comparing the sequence of
changes in eny variable after medication by linear regression. Our
period analytic program yields data describing changes in frequency
bands, in amplitude, and in the variability of both; as well as changes
of a

in

first derivative activity.

are able to process 1/2 inch IRIG compatible tape,
300; and will soon be able to process 1/4 inch
using an
IRIG tape. For our collaborators, we deliver either the data of the
primary analyses on cards or magnetic tape; or carry the analyses
through to the final stage using the school's IBM 360/40.
We

Ampex SP

Our recent efforts have been focussed on assessing the
numbered
novel compounds with preseumed psychoactive
profiles of
potential for industry. We would be pleased to discuss.this work

with
so

members

of your research division (although I recollect doing

last year).

Thank you for your inquiry.

Sincerely yours,

.m-unww

.

Max

Fink, M.D.

Professor of Psychiatry

mf/

v

.

.._, your”,

V,

0.. ,.
,

�</text>
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                    <text>W'xwm\;m.

v.

-W:w:m"r

xwx

wrumnra

um.

we

N'Ixr’m.

we".

"r,"

m",

t

1""wv.mrn v“."W"!
.

,W

..

..gqm.wﬁmw_w

W,—

mm’uW'Y-rpij‘n'mx-r‘w

,w.‘

e._r_..,,.._.,,.,,

WNW mﬂmwﬂ,

_,

.

,4,‘

m

V

.

«1w.

,

_

__

v

,

iw'wm

.

’

_

,.

'

July 10, 1970
Mr. Joseph

Lelyvald

The New York Times
229 was: 43rd

New

York,

New

Street

York

Dear Mr. Lelyveld:

I was pleased to have the opportunity today to continue our
conversation, although, I must admit, that I was distressed by
the turn of events.
of the June 4 meeting on Mucous Antagonists in
Opiate Dependence is enclosed, with s list of participants. This
summary has been accepted for publication in Science.
The summary

We

have been

notified by representatives of the

Endo

Division

of DuPont — Mr. Joseph Conlon, Vice~President of DuPont and two
associates — that they would no longer support studies of naloxone
in the therapy of opiate dependence; specifically, they would not
approve studies under

tion) before the

clinical trials.

FDA,

their

IND

(Investigational

nor would they

make

New Drug Applica—

supplies available for

I indicated that we were prepared to purchase a supply sufficient
for our immediate needs, 6 kilograms, at an approximate price of
$10,000 per kilogram - a price suggested in 1969 by Mr. David Kline

of Endo Laboratories.

since

,um‘u

"W”,hwm‘

”new: rnmmm-qvvv-mqu-"w-,m-.-.._.....,

a

.

it

was

Mr. Conlon asked us

unlikely that they

would honor

Our request was sent today, and a copy

copy of a

not to

it.

make

this request

is enclosed. Also, a

letter sent to other participants of the

June

4

meeting.

is to obtain supplies of naloxone for clinical trial.
either Endo or DuPont in their une
Any
decision.
help
you can give us to attain our primary
fortunate
be
that, we will cooperate fully
Failing
appreciated.
goal will
American
Our aim

We

have no need to embarrass

to make the complete antagonist story available to the
press - a story with many strange and sordid elements.

�~2‘

Hr. Lclyvnld

hnvc 1130 brought this issue to tho attcntton
CBS Noun, a friend and follower of our work,
havc Icrvcd an ad hoe consultant: on nu-crous occasions.

Incidcntclly, ﬂ!

chll

of Mr. Burl
and for whom

v.

of

Thluk you in advance for your holp.

Sinccrcly yours,
Pink. M.D.
Professor of Paychiatry

Max

ﬁrzkt

July 10, 1970

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                    <text>t

v 4.- "'7»‘¢‘ 2:154.

~

a)x-,v“-givr"'V‘-“

'5'

‘w «4:»:u‘,
.~

~=

:w

mmewmswu1vsa m‘ﬁw‘w’n «92's.. c—mw “HF-’7'

..,~

“"1"

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. 15-71? -1- A~-

'7‘“

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July 10,
Pragotur
U

Obecniho domu

on:

1m,“

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n’

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an

m

-

'er',

,, r— ;chrr—

A

v“;

1970

2

Praha, 1, Czechoslovakia

Ref: Matejkova
CINP

Gentlemen:

Tour # 66

I am in receipt of your letter of 8 July confirming
double rooms with bath at Parkhotel. Enclosed is prepayment in the
requested amount of $ 192, our check # 543.
2

August 10

arriving at

I ask that the reservation arrival be changed to
are arriving from Amsterdam on KL 281 on August 10,

May

? We

1025.

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

.wmmm

u yr”,..v..v_..,.,w.,,,,,,v,,,.

. ,. ‘w...w,, ..,,;
,

�</text>
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                    <text>w."-

rm»; '31“. arm—«avws-mm: "‘I'I‘mbwrmtﬁ-thzy‘uu.—_

,

ml“

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-

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July 10,

14w

19 70

.w-

-mm~.~.~

mne-

Mr. R.

J. Gradwell

National Institute of Mental Health
5454 Wisconsin lvenue
Chevy Chase , Maryland

Re: Contract HSM—42-70-98

Dear Mr. Gradwell,

Enclosed

is

a signed

DREW

certificate involving

subjects. as requested in your letter of June 22.
In reading

this letter

human

which seems to follow a standard

prior approval for foreign travel must be obtained. It in my
understanding that this contract, in justifying foreign travel as
essential to the purposes of the project, yields 'prior approval'.
I am leaving for Athens on August 4 to negotiate the subcontract, and
if this interpretation is incorrect, please advise.
form,

we"-

‘_

May I also request your secretary to send us blank
copies of Form 1034, 'Public Voucher for Purchase and Services other
than Personal'?

.,.,V

Thank you

”.77",

for your assistance in negotiating this contract.

«um-7...,”

Sincerely yours,
.z‘K’UI-'l"'g‘|nn"“z‘n-

"sun-um

Max

mf/

Fink ,

31. D I

”ms.

v-u

#‘U:WWW"W(AW

�</text>
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                    <text>July 10,

19 70

Dr. Fred Kazan
Upjohn Company
Kalamazoo, Michigan
.

.

Dear Dr. Kaban,

?
:-

h

.

--

Wm-r-mwv'u

rwv-wwwr

:mvw

ZW'u‘VCInv

‘
‘

”adv—”WW3!!!

I have checked with the New York representatives of
Honeywell, regarding the Honeywell 8100 tape recorder. They report

that the instrument was Specially designed, and does not follow IRIS
standards for head configuration, and would therefore not yield tapes
compatible with our reading system.

They indicated that Honeywell did make a Special head
which could be used to modify the instrument but this would be

expensive-~ almost as expensive as buying a new instrument. They
suggested you contact their Detroit office for further data.

“.mp1

7
w,

..

We are planning to purchase a 1/4 inch A—channel IRIC
compatible instrument for another project and would suggest that this

instrument be duplicated in Upjohn laboratories
to send us tapes. (Hewlett Packard 3960A

laboratories.

Again,

my

4

if FM
it

channel

thanks for the opportunity to

seems useful

recorder, $4,285)

visit

Sincerely yours,
Max

Fink, M.D.

your

�</text>
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                    <text>w."-

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July 10,

14w

19 70

.w-

-mm~.~.~

mne-

Mr. R.

J. Gradwell

National Institute of Mental Health
5454 Wisconsin lvenue
Chevy Chase , Maryland

Re: Contract HSM—42-70-98

Dear Mr. Gradwell,

Enclosed

is

a signed

DREW

certificate involving

subjects. as requested in your letter of June 22.
In reading

this letter

human

which seems to follow a standard

prior approval for foreign travel must be obtained. It in my
understanding that this contract, in justifying foreign travel as
essential to the purposes of the project, yields 'prior approval'.
I am leaving for Athens on August 4 to negotiate the subcontract, and
if this interpretation is incorrect, please advise.
form,

we"-

‘_

May I also request your secretary to send us blank
copies of Form 1034, 'Public Voucher for Purchase and Services other
than Personal'?

.,.,V

Thank you

”.77",

for your assistance in negotiating this contract.

«um-7...,”

Sincerely yours,
.z‘K’UI-'l"'g‘|nn"“z‘n-

"sun-um

Max

mf/

Fink ,

31. D I

”ms.

v-u

#‘U:WWW"W(AW

�</text>
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                    <text>3

m

‘unmwm"

m.»

Ir ..,.

“WW?

July 9, 1970
Mr. Fred Brunner
IBM

Corp.

475 Northern Blvd.
Great Rock, New York
.,..

.7".

v

Dear Mr. Stunner:

«mpv

W

..

Pleas. arrange to cancel

day the ordered

RPW

1443 (1800)

is installed.

rental

on the same

~wwmv:'vl—:E.w—

Sincerely yours,
«V:

-&gt;-

Fink, M.D.
Profeesor of Peychiatry

Mex

‘nl-D-gl-"

.A...

VA

auxrm-q-m-vwwwu—uur

r.

wry-v»,

T_

'muﬂmv/vvwmmwwwp‘mWWﬂL-“FE

WWW

Hrzkt

�</text>
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                    <text>,.

r..4,‘.~.‘

.m,‘

.

v

,.

..‘ v

. .w, ‘ .

w

..

.,

”-1

. .

, .
7,,,, .ﬁ,

5

_

.

u

..,r “HMLWW .
.

,.,
“W“...

_'_,l,_.,_,,. ,,.,

_

.a; wuﬂw,

,t

,

‘

.

y“

..

. r“...

71”.“.

V-.«_ ...

”u...

........

”km“.

W»; ,,«-.~.,,.A,

n-

.-

xd-Y"

"'.(I ngnu-ra-v -"v

~

rm

v‘m'wr‘wpwdu

w.

.

w‘vavrp—

w...—

Yamnwnwmww.

‘—

'wwavﬁ

July 9,

u.

,7,

,r,

3

E

E

é

1970

Dr. Allen Berger, M.D.
Associate Director
Pfizer Pharmaceuticals
Groton, Bonnecticut

:

g

Dear Allen,

%

g

the

FD

Following your message, I recalled the envelope with

forms enclosed, and added the following?

E

E

%

68—06~26:

68-06-25:

g

i
i

68—06—27:

for the lactate study, including,
form
Anxiety scale for infusion
Forms

Initial evaluation

Taylor Anxiety symptom check

list

Article from Archives gen. Psychiatry, by Curry et 31.,
Factors Affbcting CkZorpromazine Plasma Levels in Psychiatric Patients,
vol. 22:209—216.
I trust these are useful.
Sincerely yours,

.A

"w"

Max

‘va‘nI-Kﬂqup‘—VV7

mf/
ru-u'ﬂ’

-:
'

r-vwwawrxv-v

w'

vxvn-

u-

‘wﬁwmn"w"ﬁw'mwxw~

Fink,

M.D.

‘

._.

v

n

~-«

-,

-- ~-.-,—,.\._

q . Jam-w urn-cavin—

�</text>
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                    <text>.
&lt;
-

July 07, 1970

wﬂ'm""-‘

A,

.
.v

-v~'."!va14

Hearing Clerk
D. H.E.W.

Fisher’s

5600

Lane
Rockville, Maryland

”raw-1tma

Re: Methadone Regs, Proposed

Sir:

Dear

I am writing in response to the proposed regulations
”Conditions
for the Investigational Use of Methadone". Since
entitled,
1965, this laboratory and Department have been involved in studies of
methadone maintenance and other forms of narcotic antagonism (cyclazocine,
naloxone). I believe the exclusions listed, namely peegnancy, psychosis,
physical disease and age less than 18 are too restrictive, and possibly
illogical. I would suggest that these exclusions not be written in the

regulations.

'

The treatment of pregnant women is a logical step in
the methadone maineenance programs. After all, who is in more need of
help out of the sordid drug addiction cycle than mothers ? We do
not know whether methadone is safe and surely every effort should be

to investigate this application.

made
lﬂ’m'l'cmrwtwﬂ'w‘ﬂrw"

effects in
seems

Psychosis

some

be helped by methadone, which has antipsychotic
and such a study should he encouraged. Again, it

may

reports,

illogical to restrict this medication, if it is indeed helpful,

to healthy addicts only.

.rnwrmrr-n-r.

squash-F“qu

.

applies to serious physical disease. We have
successfully treated a number of older patients with eveidence of
cardiovascular disease and methadone may have heen life-saving in these
subjects. Rather than restrict the studies, I would encourage these
The same

trials

as

are to

we

particularly helpful.
If one restricts methadone to persons over 18, what treatments
offer the younger addict ? What is the magic of '18' ? While

it

would be unfortunate to start younger persons on
one may agree that
a life of addiction to methadone, is the same not true for an older person

the

These
and

artificial

restrictions are illogical to

puritanical

me, and may represent
views of the authors of this regulation,

little experience with treatment of opiate
dependent subjects with methadone. If they had, the regulations would
reflect an expression of the need for these studies, rather than their

who, I suspect, may have had

exclusion.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.......

as. ......_ ...

?

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                    <text>July 7, 1970
Mr. Robert V. Ornea
Managing Editor

Science

1515 Massachusetts Awe., N.W.
Washington, D.C. 20005

Attention:

Miss E. Johnson

Dear Mr. Ormes:

our meeting report,
I have reviewed your suggestions forhave
corrected each of
I
and
acceptable.
and find them useful
(I am not
the checklist items and enclose a citationa list.
and 7 and 9];
and
6,
[aee_items
sure how to handle repetitions
please correct).
cogent
Since submitting the report, A. Wikler submitted amarked
have
2.
I
1,
page
addendum which appears as paragraph
version for
my new page as you did, but enclose the earlier
your checking.
Thank you

for your able assistance.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

em: a

�</text>
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                    <text>:g—vtw-r-wn-m—nxv-umw ‘TwAkz-“w4v'ug

ww‘w ',V"-~v,v1"-V“»‘.x _‘-V.':‘ we.

,

V

A

n

‘37-. 1-

~

w.

”r... .,

July 7,

..

-

-.,.

Mm...» ,7.

"v.

“1.”...

“nu—nun"

m

w,

M

1970

Dr. E. N. Terry, M.D.

Pharma-Researcb Canada Ltd.
250 Hymns Blvd.
Ponte Claire, Quebec Province
Dear Dr. Terry,

I am pleased to accept your kind invitation to
the laboratories of Behringer (Ingelheim) in August.
.

visit

I will be in Athens From August 21 to 26; and hold
reservations to leave Athens for Frankfurt on wednesday morning.
August 26 on TWA 741, arriving in Frankfurt at 10:30 a.m. I also
hold reservations to leave Frankfurt for New York on Monday, August
31 at 13:45 on PA 73.
wife and two daughters (age 14 and 12) are accompanying

My

me.

I will be available to visit both installations, at
Thomas on Thursday, Friday and Saturday. If necessary
and
Ingelheim

or advisable, I can delay

sights

departure to

New York

for September 1 or 2.

make arrangements for hotel accommodations
would
be pleased to rent a car and visit the
family
about Frankfurt, and the castles of the Neckar during my
Would you

near Frankfurt

many

my

? My

kindly

working hours.

Many

opportunity to

thanks, again, for your kind invitation and for the

visit

your laboratories.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

P.S.

May

I

tell

compounds

you

that

that I have not received the descriptions of the

you discussed with me

?

V

.

_r

&gt;

( .

V.

_

”A

if,

�</text>
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                    <text>,

-

,

H...

.

t

‘.

._

&lt;

:vmlr

«

“ www

rm

«my»,

.

,1,

.\ .‘wwa-mv‘w—P

a

u

r

w»-

July 3, 1970

56Vaaﬁ'
.3

60?:

Dr. Konstantine Miras
Professor of Biological Chemistry
U
iversity of Athens School of Medici ahe

Athens, Greece
Dear Costas,

While we have not yet received the formal
from N.I.M.H., both A1 Freedman and I are proceeding oncontracts
the assumption
that we should take advantage of our forthcoming trip to Europe
to meet with you to discuss the details of the project.
Dr. Freedman can arrive in Athens from Tel Aviv about
August 13, but I am scheduled to be in Prague until August 15. I hold
reservations Prague (ZRH) Athens on Saturday, August 15, arriving
in Athens at 1835 ()A 723). We both are scheduled to leave for
meetings in Istanbul on Monday, August 17 ate 1700 (BEA 438).
We plan to
stay at the Grand Beetagne Hotel, and would
appreciate meeting with you on Sunday and Monday. It would be useful
to meet once again with Dr. Stefanis, and other members of the staff
who may participate in the
project.

After the meetings in Istanbul, I plan to return to
my family for a holiday in the city and among
the islands. This will also give us an opportunity to meet
again
to continue our planning sessions, if this is necessary.

Athens (August 21) with
I

Our

best regards.
Sincerely yours,
Max

Fink, M.D.

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                    <text>'wamw'l‘van’

-)

July 25, 1970
Dr. Charles Socarides, H.D.
210 East 78

New

Street

York City

Dear Dr. Socarides,

I thank you for your kind invitation to participate in
a panel on the ”Efficacy of Treatment of Narcotic Addiction" on
February 2, 1971 at the New York Academy of Medicine. The subject
to my associates.
is of importance and of keen interest to me andabout
the treatment
to
have
say
nothing positive
Unfortunately, I
are unconvincing,
other
laboratories
tron
of addiction, since the results
the
If
title or
are
incomplete.
and our own data, while promising,
under
study,
of
the
approaches
discussion
the focus were changed to a
scientific
approach,
its
unique
describe
our
then we would be willing to
and

theoretic basis,

and the

initial results (if

we

have them by that

are testing the theory of opiate dependence
time).
you know,
therapy based on de~conditioning using narcotic antagonists like
cyclazocine and naloxone. This approach is rooted in experimental
studies, chiefly from.Lexington, in animals and man, and bearsthelittle
resemblance to the emotional approaches usually described by
other workers listed in your letter.
With this caveat, and in the spirit of inquiry, I will
be pleased to accept your invitation, if you choose to accept these
remarks as descriptive of the presentation that we may make.
As

Again,

we

my

thanks for your

invitation.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

P.S.

be based on the joint efforts of Professor
Resnick, Dr. Arthur lake and myself.
Richard
Alfred Freedman, Dr.
The

presentation will

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                    <text>July 6, 1970
Dr. John A. Scigliano
Center for Studies of Narcotic and Drug Abuse
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Dr. Scigliano:

have completed one study with the marijuana recently
supplied us and are planning to undertake two studies during
August. In one we will use marijuana left,es£ the amount left
is adequate for our needs.
We

we wish to test the marijuana extract
hand the three ampules 880 #61152 rated
have
on
distillate.
AQ-THC.
To
17.12
at
carry out this study we will need an additional
three ampules.

In a second study
We

it

would
be
few
weeks?
next

possible to obtain this supplement within the
\

For your information I am enclosing a summary of our recently
completed marijuana experiment as well as a record of our drug use.
Thank you very much

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>”m w-nW.
V

July 6, 1970
Dr. Stephen B. Bernstein, Program Head
Early Clinical Drug Evaluation Unit
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Steve,

Enclosed is a contribution for the ECDEU Intercom. If it
is too long, I will be glad to edit it. Our programs are, as
you see, quite extensive, and perhaps this report should be
divided over a few issues.

In thinking of this summary. and

perhaps an

article

can be

my

recent cell to you,

written in Intercom to describe the

populations available to each unit. It would give us a better
view of the basis for the results discussed.
Another topic of interest is the prison methodology for
early phase I studies - who does it, where and how?
Thanks for the invitation to contribute, and my best wishes
for the success of this endeavor.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

ﬂxn'géa

_

r.

�</text>
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                    <text>vﬂ‘v'p'...“

w-w—wu.-us

”wan-mu

-1«p

1'
..

.mmnv

[Win-("wwnz-m'QUW‘WV-U—r

JN'H

July 6, 1970
Dr. S. Clyde Strickland
Merck Sharp &amp; Dohme
Welt Point, Pennsylvania 19486
Dear Clyde,
we would

appreciate

acetylmethadol.

Enclosed

an

is

additional
a signed

10 Grams
IRS 2513.

of L-alpha-

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>\\
July 4,

1970

Dr. Robert Gerber

President, APA
Carrier Clinic
Belle

Mead, New

Jersey

Dear Bob,
The form APA letter of June 30, signed by Mrs.
_Frances Davie, epitomizes the basis for my resignation from the
APA. In reading this letter, I was prompted to think of the reasons
for my abrupt action, and a relationship of almost 20 years prompts
me

to express the reasons for

my

distress.

I joined the APA about 1951. I was active in my district
branch, the Nassau NP Society, founding its Newsletter and becoming
President in 1959. I was also active in the APA, serving as an officer
of the Section on Brain Function for many years; have often presented
papers and participated in round tables at meetings; and refereed many
articles for the Journal. For the past year, in my district branch, I
have served as chairman of the committee on biological therapies. In
view of this active relationship, why this action and why now ?

I believe the APA is much too big and too impersonal. It
is insensitive to the needs of individual members. It tries to speak for

all,

not

and

my

I fear

views.

may

Speak for none. Surely the views of the

APA

are

Some of the impersonality is seen in the following incidents.
In 1966, I returned from St. Louis, where I served for four years to
establish the Missouri Institute of Psychiatry. On my return, I was
invited to participate again in the committees of the Nassau NP Society.
Because my office was in New York, and because it served the interests
of the Department to have me participate in that society as well, I applied

for membership in both, and was told by the APA that it was illegal
to be a member in two district branches Dutifully, though disappointed,
I resigned from the Nassau NP Society. (Incidentally, the threat in the
last paragraph of Mrs. Davis' letter is childish.)
1

APA.

For years I have participated in section meetings at the
Host general sessions are much too big to allow discussion. The section

�small, and though it occupied only one day of the meeting, served
to provide continuity for discussion and growth of ideas. The demise
of the sections provided another loss of the personal touch of the society.

was

The APA meetings receive many abstracts, and the
Program Committee complains that
is overburdened. For a number
of years, I have recommended presentations by younger men, only to
have them rejected. Surely this would not be a problem, if we were
not repeatedly faced by programs in which some participants present

it

more than once,

often the

same

material in different sessions.

For example, in San Francisco, the NIMH Bunney—Goodwin team presented
many times. This is another example of lack of sensitivity.
The dues increase, while necessary to assure a larger
administrative structure, is another symbol of 'hig business', and
served as the triggee to my resignation.

Perhaps this explanation is merely a rationalization
for frustrations; or, perhaps it is a reflection of the necessary
growth of the association. I hope it serves the Trustees to consider,
if only in passing, the drive to impersonality in the association.

Is

it trily

necessary
My

7

best regards, and with the awareness that the
is often thankless, I remain,

job you are doing

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>“cg-pm...

..

gunner... n.

w

".m‘mw...~.—m.;.

..

‘1

.r

1.1.1,;

ﬂyww .q.vv..-»,—lwm~

July 3, 1970
Dr. William martin
Addiction Research Center-

Lexington, Kentucky

.
..

Dear

Bill,

’lWlU-m.NV1'-

”Hwy-e

ea;

Following our June 4 meeting, Al and I have discussed the
next steps in our narcotic antagonist program. He suggested I call
Dr. Seymour Yolles, to see if his preparation could be assessed in

clinical trials.

I called him this week and found him most cooperative
and enthusiastic about his preparation. He can make some samples available
for human trial this fall; and for animal assay now. He seemed reluctant
to deal with us directly, indicating that his supply was made under N.I.M.H.
grants, and that rightfully, they should decide the next steps. He wished
to first obtain your approval for release, as well as the permission of
Dr. Sidney Cohen.
Since you have been instrumental in setting up his program,
be
not
useful for you to assume the responsibility of’assuring
his cooperation as well as that of N.I.M.H. (Dr. Cbhen ?) to bring this
method to early trial ? Al and I would be pleased to make our facilities
available for these studies, and would be grateful to you and Dr. Yolles
the program can be implemented.
would

it

if

Incidentally, the summary of the June
the
editor of‘Science for publication.
accepted by
ﬁg

4

meeting has been

best regards.
Sincerely yours,

.
WV.

Max

.7

Fink,.M.D.

Professor of'Psychiatry

«w‘w.wv.w‘,m...

mf/
cc: Alfred Freedman
seymour Yolles

10..."..1‘

..

x

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                    <text>July 3, 1970
Dear Helmut,
have
Iand

discussed your questions about EEG analysis with
with Itil, and suggest that the best methods for
my associates
your applications are still the frequency analyses using the filter
techniques available in Europe. These techniques, as provided in
the analyzers made by Kaiser in Denmark or the fixed filter units
available from England will db the job very well, at much less expense
than any of the computer methods. As I understand your problem, it
is to measure the EEG changes under different conditions of‘cerebral
dysfunctoin, and for this a frequency analyzer is ideal; particularly
since you will be able to compare the differences between electrodes
pairs on two sides of the head. Our focus in computer methods is
largely because we are assessing the methods for special problems
in which the changes are small and we have to depend on changes from
session to session or after a drug.
The equipment has been used by the Czechoslovak group
working in Prague with good results, and they have had the Kaiser system

for

many

years.

Good luck I

thank you fbr your kind invitation to visit. I will be
at the CINP in Prague this August, but my present schedule is complicated
by the desire of'my family to visit some of the sights in Greece and
Turkey, where I have projects. I do not think it will be possible

I

to visit Gras with them this trip, but I will be in Europe again this
year, and will make a trip to Gras, not only to visit your laboratory
but to try gliding as well.
,

It

was good

My

best regards.

answered your questions.

to have you

visit,

and

I trust that I

Sincerely yours,
Max

Fink,

M.D.

have

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                    <text>v-rr—uv

wrw-r

thml-vzwu.vwwwww

m

v.

July 3, I970
Mr. John E. Ringle

Science
Washingfon, D.C.

Dear Mr. Ringle,
In re—readlng fhe reporf of The meeflng on Narcotic
Antagonists in Opiata Dependence, we have made a few smaII correcflons
In +he fex+. A correcfed copy Is enclosed and we would ask Thaf fhe
copy edlfors use +his correcfed version for preparafion of fhe

galleys.

Many

Thanks

for your cooperaflon.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
mf/

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                  <elementText elementTextId="105954">
                    <text>r
..

mm“

“Hwywr

M

-

wvw-ucv'wr W. ”Minn-'M

,

r'

way-rm:n .

3‘

‘I'S’WmMun-1w new

‘wm'm 'm—Ur 4mm? m:m.ww—nr

-

.w

'[vpv-p—n!‘;.

s..ww‘wu‘m.

"WW4.

July 3, 1970
Dr. Vilma Harrison
Geigy Pharmaceuticals
Ardsley, New York

mm.

.

---Im‘-'Zv";r

Dear Wilma,

n‘

w:

As

I mentioned

on the phone,

I have

discussed the

willing, interested and able to evaluate the
list of clinicians
and
antianxiety effects of new compounds with some
antidepressant
and
with Dr. Stephen Bernstein of the ECDE'U program
associates
my
of
The
MIMI.
following
investigators should be considered for
of
an evaluation of GP 41399.
Schiele and Abussahab:
University of Minnesota
Cole, DiMascio, Schader:

Goldstein:
Rickels:
Merlis:
Klein, D.:

Boston State Hospital
University of Mimi

University of Pennsylvania
Central Islip State Hospital
Hillside Hospital

There must be others, but they do not come to mind in this
review. Occasionally, Hollister (V.A., Stanford) has taken on a new
compound; Sugerman has done some OPD studies at a private hospital in
New Jersey; and Gallant (Tulane U.) has reported on cmtidepreseant and

antianxiety
to

compounds

in alcoholics.

is anything
I trust this is helpful.
Ifonthere
me.
in
call
this
assist
venture, please
My

I

can do

best.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry
mf/

.

,: m.wan—m ,r-wW

:s

...,..w

a. «Y w-l-

�</text>
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  <item itemId="4476" public="1" featured="0">
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        <authentication>2b1971c9d3be1ed80750d66cc5298272</authentication>
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                  <elementText elementTextId="105955">
                    <text>N‘—

"

4»

-'~~=-

-

u-u-

.—

~-r-r..~u.w—

u- . , grim

"w' ..:,

w. ‘v-‘(M' v.

,

.

.. .-..._..m=—~wmw~wqur-.muvv.nw 2-“

«W

.5 .‘If‘l:

no. ”warm... .7,..,,.,

July 3, 1930
Dr.

J. Alan Burdick

university of’Manitoba Faculty of Medicine

Hinnipeg,

3

Manitoba

F
E

Dear Dr. Burdick,

Perhaps there

is

need

for such a

volume as you

and we should contribute to it. I do not know when
find the time, but should try to do so this fall.

I will

project,

be able to

I'would like to describe the development of.EEG
emphasis
quantification of’special interest to psychopharmacology, with
the
to
analysis,
frequency
in
analog
on the historical beginnings
as I have in my
present digital computer methods. I will weemphasize,
considerable
had
have
EEG,
human
although
waking
studies, the
As a
methods
recordings.
to
sleep
these
experience in applying
useful descriptive title, I would suggest:
Quantitative

EEG

and Clinical Psychopharmacology

Spectral Analysis and Clinical

Pharmacology

or,

EEG

or,

Applications of'Digital Computer Analyses of the
EEG

Ag

to Clinical Psychopharmacology.

co~author will be Donald

Good luck

M.

Shapiro, D.Sc.

in your venture. with such a project,

you should be able to interest a good publisher and obtain a
which may bring a return to the contributors.

to have you

.Lf you

Human

visit

New

York,

visit our laboratories.

my

associates

I believe
contract

would be pleased

Sincerely yours,
muﬂw‘

was:

Fink,

M. D.

Professor of.Psychiatry
mfy

�</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="44757">
                <text>1970 </text>
              </elementText>
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            <elementTextContainer>
              <elementText elementTextId="44758">
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              </elementText>
            </elementTextContainer>
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                  <elementText elementTextId="105956">
                    <text>July 3,

1970

Dr. Allen Berger

Pfizer

&amp;

Co.

Groton, Connecticut
Dear Allen,

first

I enjoyed your visit
installment of the material

on June 23, and I

we

am

discussed.

enclosing the

have prepared a protocol for the assay of the
Infiuence of.PCPZ"5h Tolerance and Physical Dependence in Opiate Addicts.
We have reviewed the administration schedule, and following your discussion,
have added trials of PCPA on alternate days and daily, if the schedule
of every 4 days is inadequate.

1.

PCPA.

We

,

for this project, that
is one technical problem5-HIAA.
we do not have
and
5-HT
urinary
blood
of the measurement of
have
contract these
and
to
will
the facilities for this measurement,
can be done in
unless
they
commercial
laboratory,
measurements with a
assuming the
contract
the
costs,
Our
for
estimate
your laboratories.
is $3,000.
number
tested,
of
maximum
cases
project proceeds to the
There

have reviewed the data on cidoxepin and
Presumed Anti-Anxiety,
prepared a protocol, Elinioal Trial of CidaxapinWe
would
like to assess
Dependence.
Anti—Depressant Agent~ In Opiate
2. Cidoxepin.

We

in this
the possibilities of clinical trials of anti~depressants
of patients.
number
limited
a
in
and
a
suggest trial
special population,
and
clinical
dosage
define
range
a
able
be
to
In this study, we should
definitive
a
be
able
to
suggest
will
activity, and based on this data,

trial.

We

the

summer

holidays,

the supplies

be able to begin the cidoxepin
on or about September 15.

will

trials

only

after

(we can begin the PCPA study in mid-July or as soon as
are made available. 200 capsules of 25 mg. each should

be adequate to

3.

start; with
EEG

matching placebos

if possible.)

Trials in Prison Volunteers. This suggestion is

most interestingT"EEa‘yaﬁf'f5116ﬁ=ﬁp’feliphoﬁ3'call to indicate that
your technician will visit us on July 17 confirmed our enthusiasm. To
will be necessary that equipment be available
carry out this program ,

it

..,.,

,
a
A-

.
-‘Wrwv

�at the prison to insure recordings that will be useful. I will
describe our procedures and caution the technician, but the following
should be considered:

equivalent to Grass polygraph with 7P511 amplifiers.
Grass Instrument makes a small 4 channel instrument, which can be
initially equipped for recording on 2 chainels only. $4,500 ($3,000)
EEG,

Tape—recorder for FM.

to the Hewlett Packard

A

3690A.

small 1/4 inch unit equivalent
$4,285

Oscillator, equivalent to the

2020

HP

$

425

Oscilloscope, for monitoring, preferably dual

beam, any make equivalent to the Tektronix 561

inexpensive.

The

tapes, paper,

$1,000

and other supplies are

relatively

it

would be useful for me and one member of my staff to visit the installation and develop the initial
protocols in collaboration with your staff there. I would envisage
the recording of EEG samples on paper and magnetic tape; having the
paper records examined in conjunction with the clinical data; and then
analyzing those tapes that seem the most useful for the definition
of drug dosages using the advanced computer techniques of the EEG

Prior to the studies,

laboratory.

not have a 1/4 inch FM tape
unit in out computer center. It will be necessary for us to provide
a duplicate unit or for you 00 lend us your unit whenever we undertake
the analyses of the tapes.
As

I mentioned,

we do

4. EEG Profile Study of Doxepin Pamoate. I have not
received the pharmacological data for this formulation, and so have
hesitated to prepare a protocol, but will do so as soon as the infor—
mation is received.
The thiothixene-EEG

reports are progressing rapidly.
Thank you

these diverse studies.

profile,

and the

for your suggestions,

CP

14,368

EEG

and I look forward to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

profile

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:r’alww .mu-zw—a—wwq-p-mvm

w-“

July 3, 1970
President
Mallinckrodt Chemical works

St. Louis, hissouri
Dear

Sir,

Since 1968, we have carried out clinical studies of
naloxone in the treatment of’opiate dependence. Supplies have been
provided by Endb Laboratories, but they have been unable to
make sufficient nalosone available for oral studies. In December
we requested additional supplies and these have not been forthcoming;
they have indicated that the supplies are male in your laboratories.

In discussing this with the officials of the New York State
Narcotic Addiction Cbntrol commission, they offered to make funds
available for our independent purchase of'naloxone; and such a
contract has been received by this Department.
would like to purchase 3 kilograms of'nalcxone; preferably
in 300 or 500 mgm tablets or capsules. Is it possible for
your laboratories to make such a quantity available? At what cost
we

made up

and with what delivery schedule ?

are unable to supply this quantity, can you direct
If youlaboratories
either here or abroad that can ?
other
to
us
an...

We

am..-

'1

--

either

U.S. customs,

have

or can obtain the necessary

etc. clearances.

FDA, BNDD,

my".

Thank you.

Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

mf/
cc:

Endb

Laboratories

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                    <text>a.
u.

rv'u‘vr

aux—nu.

.7

,_",.c,m..",

,

r u .

nwvw-c raw—W

'

'v-r

:

raw

1"

July 3, 1970
Dr. Ed Domino

Lafayette Clinic

Detroit,

Michigan

Dear Ed,

It was kind of you to spend so much time with me on
Tuesday. I was very impressed with your facilities and with the
catalog of interesting studies which ydu and your associates are

undertaking.

I am particularly interested in your studies of
acetylcholine and cholinesterases. For the past 18 months, I have
studied the behavioral, EEG and memory changes induced by unilateral
and bilateral ECT, and recently have expanded the
study to include
multiple monitored ECT, in which the subject receives
3-8 seizures
1g one sitting. In reviewing our data, and in View of the
interest
in CNS neurohumors in depression, I became interested in measuring
the neurohumors in the spinal fluid of these subjects.
Alex Karczmar expressed enthusiasm for this study, and
have planned to send him samples, taken before and
after the
induced seizures. As you know, the techniques are
notoriously
difficult, and any collaboration and assistance, would
be most welcome.
If the problem is of interest to your associates, I would
to make samples of spinal fluid available to you as well. be pleased

we

If the problem is of interest, may I ask that you arrange
to have your assistant write, describing the necessary
to be taken in sample collection, sample size, shipping,precautions
etc.; and
we will send you a detailed protocol (now under
revision) and make the
necessary arrangements for the fall.

trip

my

thanks for your time, and my best regards in your
It sounds interesting and I look forward to a report

to Russia.

this fall.

BSncerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>A.

.
t

WW,

n...“

“F...

July 3, 1970
Dr. Ralph Jacobsen

Endo

Laboratories

Garden City, New York
Dear Ralph,
Thank you

for the corrections to the

summary

of the

meeting. I will make the changes, and I am pleased to
the
that
summary has been accepted for publication in Science.

June

4

we

tell

you

have had an opportunity to discuss the problem of continuing

our studies of oral naloxone. Aware that our request for additional
supplies for oral trials remains unfulfilled, we have requested support
from the New York State Narcotic Addiction Control Commission for our
independent purchase of naloxone from any available source.

It is my understanding that Mallinckrodt Chemical Co. is
the principal U.S. source of the compound. I have written to the President
of that company, enquiring as to the possibility of their supplying
naloxone for our use.
I

would appreciate ypun cooperation in

this request.

It would also be helpful if you could tell
potential sources of supplies of naloxone.
Many

us of other

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>July 3, 1970
Dr. William Martin

Addiction Research Center
Lexington, Kentucky
Dear

Bill,

meeting, Al and I have discussed the
next steps in our narcotic antagonist program. He suggested I call
his preparation could be assessed in
Dr. Seymour Yolles, to see
Following our June

4

if

clinical trials.

him this
I called
about his

week and found him most cooperative

preparation. He can make some samples available
reluctant
for animal assay now. He seemed
trial this fall;
for
N.I.M.H.
made
under
was
his
supply
to deal with us directly, indicating that
He
wished
the
next
should
decide
steps.
grants, and that rightfully, they
to first obtain your approval for release, as well as the permission of
and enthusiastic
human

and

Dr. Sidney Cohen.

Since you have been instrumental in setting up his program,

it not be

assume the responsibility of’assuring
his cooperation as well as that of N.I;M.H. (Dr. Cbhen ?) to bring this
method to early trial 7 Al and I would be pleased to make our facilities
available for these studies, and would be grateful to you and Dr. rolles
the program can be implemented.

would

useful for

you

if

to

'

accepted by

Incidentally, the summary of the June
the editor of’Science for publication.
my

4

meeting has been

best regards.
Sincerely yours,
Max

Fink,

M. D.

Professor of’Psychiatry

"#7

cc: Alfred FreedMan
Seymour

rolles

�</text>
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                    <text>«equw-r-au

~

mgmrwnvmmgv

nun-‘3.

cur-\—

rw

ﬁi'wﬂlw

nan-"Iv

Ms...

July 3,

1970

Dr. Alex Karczmor
Stritch School of Medicine

Loyola University
Chicago, Illinois
Dear Alex,

notified by EIMH that our application for
supplementary support [or the studies of CS? in the ECT process
We

was

have been

not accepted.

Dick has sent one sample, and during the past 2 months
we have been writing up the results of the first tsudies and planning
the new ones to begin'in late September. I do not know what
arrangements we can make, but I believe that we will be able to make
samples available and hope that we can work something out.

I will call

and we can decide then how
My

after

return
to proceed further.

you immediately

best regards for a

my

from summer holidays

happy summer.

Sincerely yours,
Pink, 3.9.
Professor of Psychiatry

Max

P.B.

we

should have a dinner in Prague, at

_

least

1

W

�</text>
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            <elementTextContainer>
              <elementText elementTextId="44821">
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            </elementTextContainer>
          </element>
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            <name>Rights</name>
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            <elementTextContainer>
              <elementText elementTextId="44822">
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          <element elementId="48">
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="103348">
                    <text>rumm‘pwm.t-“W,

Wynn-n.

”WW—W5 ---A1mw wﬂ-r‘

n—de—WJ'M

.,

w

"NV-V

“a

';:I-«urql’."‘ ”aw:

warm r" WV-v' WW

*1

4

W"? “V“

' " “'

July 3,

"‘

'

1970

.

"are—xv

«um-WW“

,,
,.

Dr. Ernst Rodin

Lafayette Clinic
951 East Lafayette

Detroit,

Michigan

,.,

H,

.,
v

rpm".

Dear Ernst,

our".

A

.w‘twﬂ'mI-T‘qunw;

r

('"Y‘lxﬁ'wv'rn‘nv-t

m,

_-i-Vyrt&gt;

-("th,

em.

3-5:",

I want to thank you for your courtesy and patience
in explaining the operation of your IBM 1800 system, and particularly
your use of that system for data acquisition and processing. It
was kind of you to take the time from your busy schedule, and I
am

most

grateful.

Perhaps, I did not express my enthusiasm for your
observation of very fast frequencies in the EEG. When Turan and I
looked at fast frequencies, we looked at 80-150 cps, and in one study,
of the effects of pentothal, we found interesting frequency changes,
but these were not unique to the fast bands, and we were not sure that
we were not dealing with artefacts. Your focus on truly fast frequencies
is most interesting and I look forward to the report and the responses
at the EEG meetings this fall.

-.7,Wawwn

My
.12y.~

best wishes for

a happy and healthy summer.

Sincerely yours,

Iii-(vsm'mmtmmﬁ

Max

WHHW

mf/

Fink, M.D.

�</text>
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September 30, 1970
Dr. Milton Tarluu
Kew Gardens General Hospital
80-02 Kew Gardens Road
New York, New York 11415
Dear

is an abstract for your consideration for the
meetings. If the topic interests you, I would be
pleased to bring the membership up to date with an interesting
Enclosed

1970 EAEEG

set of practical developments.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

"HT-WW

‘
t

1

”ﬁrm

Murrow

~x

Milt,

Mszt

—r~.—-.-wv.

"’J-rww‘

-

�</text>
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                    <text>....

v vw "nav'uwl: m'JKIL-‘r

-:"'n;'!.‘—K\

urn-n

u n. v-ww:""~ "'0’..’ll"~ ~r-wrmn~m

hwy-‘4

w.

at;

Wu.-

..~...--

._.

.

v

m

.7

,.

r,
v,‘,-.—
_.. “re—v7“
“'Kif’ . Kan—".7 '11 .w.
,

,

wVlrr‘ \m- w... Vg....N:
,

.

.

M

2 -.~

September 30, 1970
Addiction Research Foundation
344 Bloor Street West
Toronto 4, Canada

,..._.,

.

.Jymwuwu.

Wham.

rm

ﬁn-

Gentlemen:
I have received "An Interim Guide to the Cannabis (Marihuana)
Literature” by Oriana Josseau Kalant and I have read it with great
interest. I wish to commend the author for a clear and unbiased
review of a difficult subject. For those articles which I already
knew, I found the technical statements clear and usefhl.
Many

thanks for sending

me

a cepy.

Sincerely yours,

WT:

Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 29, 1970
Chairman

Internship Selection Committee

Dear

Sir:

to me as a Summer Research
Trainee in 1968. He participated in our study program of EEG
changes with psychoactive drugs in normal volunteers. He became
Mr. Alan D. Morris was known

acquainted with the normal human electroencephalogram and developed
an appreciation for the subtle changes accompanying threshold

drug dosages.

an intelligent, cooperative and friendly young man.
grﬂat efforts to accomplish his assign-ants. He exhibited
an enthusiasm for pharmacology and I very much enjoyed discussing

He
He made

is

his ideas.

Since his freshman year, I have occasionally met him at
meetings in the College. He continues to exhibit an enthusiasm
in medicine and I would recommend him highly for continued

training.

Sincerely yours,
Fink, M.D.
Professor of PsyChiatry

Max

MFtkt

�</text>
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w

A-

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.v

rwwwn-u.wumAv'v‘ur’."

-

NNK‘VW"“¢ "Wm

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an:

A.“

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September 28, 1970

-'~=v't

r.“

:1
«‘u

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:c'

Dr. Wiles Harrison
Geigy Pharmaceuticals

Ardsley,

New York

-h’\r~'lw‘ﬂ’..5.m-

Dear Wilma,

91

A

2

cum;

I have read the two EEG studies of GP 41299 by Kales and
Denent with great interest. I have read of Kales' sleep studies
for a few years, but this is my first opportunity to directly
compare my techniques with his. Dement has not previously been

identified with

new drug

studies.

Both studies suggest that GP 41299 enhances REM activity a finding interpreted by Deuent as almost unique (see pg. 23).
Kales failed to elicit effects on REM at 50 or 100 mg doses.
Both Denent and Kales, for reasons that are not specified,
suggest studies in insomniacs. This recommendation does not
seen to be based on the study data, but on information which

is not clearly stated.

striking, in both studies, is the absence of statistical
sophistication in defining the drug induced EEG changes. I was
surprised by the small sample size, and the impressionistic nature
Most

of the

summary

statements.

I cannot determine the relation of this data to the alert
but I am most grateful
profile of GP 41299 as we defined
for the opportunity to examine these studies and to attempt such
a correlation. I find nothing in these data to be inconsistent
with our observations or conclusions, and would continue with our

it,

BEG

suggestions.
and

Again,
my

my

thanks for the change to read these two reports,

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>_,

,

V

mun.

v

.

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,. me.

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,

my

-v‘

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September 28, 1970
Dr. Richard H. Runser, M.D.
Medical Director
Wallace Laboratories
Cranbury, New Jersey 08512

Ire":

14.

Dear Hank,

inv—

“1.1m.

I was pleased to have the opportunity last week to discuss
the continued evaluation of W 2354. While I am most interested
in applying the EEG profile analysis methods, it seems that such
a study now would not serve your long-term interests. As we
discussed, it may be more profitable to continue clinical studies
in arthritic patients, at various dosages below those reported
from New Orleans as producing gross

CNS

effects.

In these subjects, the concurrent sampling of EEG, with
suitable attention to time of recording, dose of w 2354, electrode
montage and amplification, will provide additional information for
an EEG profile study. It may be useful to have the EEG records
from different centers obtained according to a common protocol,
particularly if you wish us to review the records for evidence
of central effects.
We will be glad to cOOperate, and both discuss with the
electroencephalographers, our recording needs, and review these
records on your behalf.

If this project continues, it

would be most useful

if we

could establish a consulting relationship, which will permit you
to call on our facilities as the project may require.
My

best to Milt.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

van—w..avmvmw-w-rvw-

r.‘!‘r~' .. w“ .__

�</text>
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rw'

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,

,

V

I-N.‘wnt-n'nv~wrn1lrmv\.v-'-

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‘,.._,..‘

September 28, 1970
rwwwmv“

Mr. Robert L. Marlin

Sandor Pharmaceuticals
Hanover, New Jersey 07936
Dear Bob,

I have read Loo Goldstoin’s report of his EEG analysis
of 42,548 with great intorost. The data is not inconsistent
with our own, and should therefore, be useful to you in your
3

,
r-

1",

decisions regarding this compound.

~—

vwn‘l

Thank you

for the opportunity to road this report.

w’i“|Wl-m-

‘

Sincerely yours,

Wam-m-w—u—wm

Fink, M.D.
Profossor of Psychiatry

Max
rw-

v.

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                  <elementText elementTextId="103352">
                    <text>r -W-

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u

.—

mm

, .m

“Mm...”—
,

,

.

~v——-‘

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..

r-"I

warm-Vane!

September 28, 1970
vm‘v‘vmmw

Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139

-

Dear Turan.

Enclosed

and the forms

is a copy of the letter from Dick
for the conference registration.

Would you
My

scrape up an abstract and send

it

Roch;

to

best to Ellen.
Sincerely yours.

‘

r:
_‘

"w

Pink, M.D.
Professor of Psychiatry

Max

"ﬁr

-.~«

”3“"

mwo,ﬂ.,r‘

riwwtpwunr&lt;njuxw

v»

rwv—w.

I'm

3

7'4

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:um-a

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v.“

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011C .

my

answer;

him (or no)?

�</text>
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                    <text>9

..

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H.737-

w... )Iusl‘l'w‘umw‘1Y

wnv,~mu-vmmmza.

.

w ,

«,H.“

~._v.-

w:

“‘-

"wﬂw

WWW-Av."

r
-.
&lt;

.

”mu—amu-

"a...“

September 28, 1970

um:.-v~m.-m.«-.

uwz‘.n'

IW‘V‘

Wm

Gmmm‘

mim

W

Dr. Richard H. Roch

Associate Professor of Pharmacology
Dartmouth Medical School
Hanover, New Hampshire 03755
Dear Dick,
Thank you for the outline of the 1971 Aspen meeting
program. Both Itil and I will participate. Shagass is unable

to attend but suggested either Heninger (Yale) or Seletn (Univ.
of Missouri) as capable alternates. Before inviting them, I
wonder if we don't have enough with five speakers? There are
2 hours allowed and I think we prefer discussion to another
speaker.

;

seem fine.
one for me.

Titles

enclose

Looking forward

to

I have asked

Itil

for

an

abstract,

Aspen.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

and

,_

m’- u—wvv-w.

1-

:

‘_,_ rx

m.

�</text>
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              <elementText elementTextId="44912">
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                    <text>.‘W-mvW...

-.

v

7.-

er

"1.7,...
r1-~.J“... mv .. w”...- w "w... .. as
.

.-

W

.
wJ12

, v5.

.
w “cu-u.

,

‘~ve‘4‘n‘7lww'a

.

.

mum.

vim—"vow“: .._--,........n..v—yw.....7,.

in, ...,,,,...___..,,‘"r_

_

,
..

_,__,

3“").

,~

September 28, 1970

.
envy—l“,:,.ﬂ.,mun_r,ﬂ,m,

Mrs. Pat Walter

Brain Information Service
Center for Health Sciences
Los Angeles, California 90024

UCLA
”mgr—raw

.

-.

-

run,

Dear Mrs. Walter:

I
a

I have found

.,
.m—v

.v—r

m—

,vs-wa

..

earlier citation lists helpful

to request cepies of the following:

«7

20.0, 20.1
22.0, 22.1, 22.2, 22.3

W",‘Wlw~

..-gs

W'

w.

‘
12‘.»

.

runwa-

vaqv-

mt
:32a

81"”m-‘Wmmﬁu

WW'I'P’WW‘

writing

16.1d
16.5

.

m

w

and am

In 1964, I published a "Bibliography of EEG in Human Psychopharnacology" (Blsevier, BEG supplement 923) and have maintained
It may be useful to attempt a decennial
my files since then.
addition in 1972 (the listings ended 1962). This will be a large
task, and I an writing to ask if the BIS can cooperate. If so,
I should like to visit on my next trip west.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

YWWW.

_,

m

—.

\.

.

‘

�</text>
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            <elementTextContainer>
              <elementText elementTextId="44922">
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                    <text>—v,_—A

war-1w."

“nu-mu;-

'ij

"ea-”warp

'“““

Septenber 28, 1970
Dr.

Pierre

Simon

Centre Universitaire

Pitie-Salpetriere

91, boulevard de l'Hopitel
Paris (13°), France
Dear

Pierre,

Thank you for the articles on sulpiride. These were
most helpful, and as you suggest, the data is indeed uninpressive.
An EEG profile analysis would not be sufficiently helpful to reply
the expense and effort.

For the

will restrain

Copenhagen, I hope the Program Committee
the ehairnan to, at most, two parallel sessions!

GIMP

Many, many

in

thanks for your kindness in sending the articles.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 28, 1970
Dr.

J ack

Preund

A. H. Robins
1407 Cummings Ave.

Richmond,

Virginia

Dear Jack,
Dr.

Pierre

Simon has

candidly cnswered my inquiry regarding
the enclosed articles. I have read them,
and tend to agree with Dr. Simon that the data is uninpressive.
It is particularly disturbing that the "best" results are in cases
in which other drugs were simultaneously given.

sulpiride,

and sent

me

I am disappointed with Borenstein's

had a chance to read the

than his

earlier reports.

If useful to
I

data,

now

full report. These data

that

seem

you, I will write to Dr. Nourricier.

will send the other reports, as

I receive them.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt

I have

less rigorous

�</text>
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                    <text>September 28, 1970
Dr. Edger Grunweldt
Geigy Pharmaceuticals

Ardsley,

New York

Dear Ed,

Enclosed is e xerox copy (with Table I corrected) of the
published report, "Ketiprenine in the Therapy of Depression in
Outpatients”, as published in Pszchosouetics, 11: 342-346, 1970.
Again.

my

thanks for your interest in this study.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszt
0316 .

�</text>
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                    <text>wwwmww'n’mww

'm‘mm

Hum-er

-

Wiewl‘m’v'wxum'mwr'zs-v

WWW
,

rnxmvpmvvurv-wv;

«nun..- rrmw ~l4—1Vauvs-nm‘w

,

,

w4my

Septenber 28, 1970

'U-vwr'rll'r

“wanna":

Dr. Virgil A. Place
Ales Corporation
950 Page Mill Road

Pele Alto, California 94304
Dear

Virgil,

The prosteglendin sessions were most interesting and I
went to thank you and Peter for bringing them to my attention.

Enclosed

is the marijuana pro-print

study is not yet in press.

you requested.

The

In reviewing data in my files on the relative potency
of antipsychotic agents, with a view to their use in 1 long
acting formulation, 3 table of relative dsily dosage ranges
shows the following:
Fluphenazine
Buteperezine

w

Trifluperesine
3Wf—WWWWWHVW

Thiothixene
Relaperidol

Stelezine

Nevene

Haldol

5-40

10-60
15-40
10-40
15—45
2—4

we

look forward to hearing from you.

Sincerely yours,

N‘WWWHYWW'W'HG

‘

”‘e‘

Fink, M.D.
Professor of Psychiatry

Max
W;

THE

M?:kt

_

.'

‘

H

V'w,,n,.

(mg)

Serpesil
I have selected representative drugs of different chemical classes
from s larger table.
Reserpine

‘-'

Prolixin

Repoise

�</text>
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                    <text>A

rv‘vvr

ImWr—V

1w-|"‘

a."

Mr. P.

TO:

Mas

FROM:

SUBJECT:
.

-m

vw—wrwng,yn—-

ru—l

"-rmra—

N.

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vac-x-

Terri, Purchasing

DATE:

September 24, 1970

Pink. H.D.
Contract with Hydrosystens,

In June

PG

0505442

negotiated a contract with Compro-Hydrosystens to
purchase a printer for our IBM 1300 system. The purchase price was
defined in relation to the compatibility with the remaining components
of the 1300 systea. In order to assure this coapliance to the equip-out
description. we added that the contract would be operative only if
the software was fully coepatible with our system.
During the sue-er, various coauunications between the aanufacturer‘s
staff and our own suggested incoapatibilities in software. 0n Septeeber 16,
1970 they indicated that proper functioning according to their contract
would require an additional expenditure of 33,000 and sons indefinite
delays in eating the systems coapatible.
we

On September 18, Dr. Shapiro, at no request notified Hydrosystens
(Hr. spadefine) that the revised contract proposal was unacceptable.
I requested cancellation of the contract that day with the understanding that the terns, both in tine and cost, would not be set.

Hydrosysteas re-opened negotiations today (Septeaber 23) by
indicating that they were able to sect the contract as specified
in June (without the prograa changes). This was unacceptable and
Mr. Spadefino then indicated we would be liable for cancellation

cut’

0

wwwv-r-

www-

n-wa

,—
A:
,.

wwwmmahmw

'm

pave

It is clear that the discussions of August and early Septeaber,
culminating in the revised contract represented a renegotiation of
contract (as of 9/16] which we did not accept (9/18) and which were
not acceptable today (9/23).
Neither a cancellation penalty nor a request to fulfill the
contract without additional costs are acceptable at this time.
Our cancellation is not based on the price alone. but on
the determination that the software problees were significantly greater

Addendua.

initially stated.

than

Wzkt
cc:

1. B. Schwarta (Ref. 41-382—‘)
Mr. T. Bannon

�</text>
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                    <text>September 24. 1970
Mr. John F. Amarosa

Eastern Regional Service Manager
Corporation

Ampex

75 Commerce Way

Hackensack,

New

Jersey

07661

Dear Mr. Amarosa:

Separately, you will receive a purchase order in the amount
of $733.00 to cover repairs of Ampex SP 300 Serial #366436 and
Channel

(AMPEX)

#7.

Per your telephone conversation this morning with Dr. Volavka,
enclosing samples which you requested. When you are ready
to return the SP 300, please let us know in order that you may
I

am

pick up the other amplifier at that time. The amplifier is located
at Metropolitan Hospital, Department of Psychiatry, 15th floor,
room lSAQ.

As

this is

a locked ward, we

of delivery in order that a
Thank you

member

will need

of our

staff

can

advance

for your assistance.
Sincerely yours.

Professor of Psychiatry

kt

notice

assist you.

�</text>
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                    <text>September 24,

197G

Administrative Secretary
Administratiye Office
American Society for Clinical Pharmacology
and Therapeutics
1718 Gallagher Road
Norristoun, Pennsylvania 19401
Dear

Sir:
I

writing to sponsor the nomination of Ali Keskiner, 3.9..
I have known him since 1964, when he
joined the Missouri Institute of Psychiatry as 3 research fellow.
for

am

membership in the ASCPT.

He is a well trained clinical
with particular
interest in clinical pharmacology. psychiatrist
He has published more than
15 experimental
papers, and is an expert in the therapy of

schizophrenics.

It is

a pleasure

to

recommend

his election to

membership.

Sincerely yonre,
Fink, H.D.
Professor of Psychiatry
Max

HP:kt

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                    <text>m,

-Fr,”

vm-

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mm,

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Governor Nelson Rockefeller
Albany, New York

September 21, 1970

Dear Governor Rockefeller,

In your campaign for re~election, your opponents are
NACC program as a failure. In one regard, NACC has

criticizing the
shown

responsibility, in supporting studies of opiate antagonists

as an alternative treatment and prevention for opiate dependence.
.
.

“rt?-

y‘a'vﬂ'mrlv"

‘45.";

_

'm,

’EZfWE.Vr"hY:'1-$'ygw1g

$7.7».

There is a substantial subcontract for the continuation
of this work before the Commission now, and if approved (as I expect
it will), may represent a legitimate opportunity for your administration
to claim public credit for an important development in addiction
research.
The antagonist studies at this College have been supported
by New York State since 1966. The subcontract is by New York Medical
College with the Food and Drug Research Laboratories of Maspeth,
Long Island. Dr. Alfred M. Freedman, chairman of this Department

of Psychiatry, is the principal investigator of this study. The
contract is now in the Commission offices, before Mr. C. Drysdale.

lame-r.

w

,

Sincerely yours,

new

-

~;
-:

“tan-mwm'nwv.

Max

9.x?

H

a

mf/

{we

Vx:,

rm,

,w¢;m7mmm;wwmw

.mwmwxlm'lﬁe

_

Fink, M.D.

Professor of Psychiatry

mm

&lt;

.v

, on

‘-

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-- .,

var ,,,
.

-

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.1

�</text>
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                    <text>September 19, 1970
Dr. Charles Shagass

Eastern Pennsylvania Psych. Institute

Philadelphia, Pa.
Dear Charlie,

It will be a pleasure to participate in the ACNP Study
Group III in December, and I would like to give a progress report
on our drug classification studies, focuasing on methodological
issues. lzere is one problem, however, and that in a potential
conflict with a symposium organized by Al Freedman on Cannabis.
As a

title:

EEG’

Profile Analysis of Alert

Manfor

Psychopharmaoology: A Progress Report.

As additional participants, perhaps you would consider
Anthony Kales,aﬂilliam Dement and Ian Oswald. These are very active

in

EEG

classifications of sleeping man.
If you have limited funds, I

wonder

if

Bradley

is the

best resource person. Have you thought of Oswald or Borenstein ?
Philip does little psychophnrmacology relevant to human clinical
problems, while Untold and Borenstein do.
An

abstract will follow shortly.
My

best to Clare.
Sincerely yours,
Max

oil

Fink, Md).

Professor of Psychiatry

“n

on”

�</text>
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                    <text>September 18, 1970
Control Data Corporation
575 Lexington Ave.

New

York, ﬂew York

Attention:
Dear

Mr. Pagano

Sir:

RE:

Customer #4596

Effective this date please cancel our rental agreement

on the 0217

digiscribe display.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

cc: Hr. Tozzi
Mr. Tozzi:
CDO

requires

satisfactory.

us out of

it,

us

to notify

them and

this letter should

be

contract has a 90 day clause. If you can get
they can take the scope immediately.
The

ELF.

�</text>
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                    <text>September 18, 1970

;

Mr. Fred Brunner
IBM

Corporation

475 Northern Blvd.
Great Neck, New York

Dear Fred,

In view of our purchasing the IBM 1443 on this date, please
IBM maintenance agreement #HlOOG? to include maintenance

revise the

on the 1443

effective this date.

Please revise our monthly charge for September rental and
maintenance of the 1443 to reflect this purchase.

will issue a new rental agreement for the
effective October 1, 1970.
We

Thank you

keypunch alone

for your cooperation.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 17, 1970

Earl Ubell

Mr.

CBS~TV

51 West 52nd
New

York,

Dear

New

Street
York

Earl,

%ile

I was only able to see the

first half

of the series,
clear exposi-

Drugs A to 2,1 was impressed that your text
tion of the state of our clinical knowledge of drug abuse. It
was a good job, and I am writing to ask whether a typescript,
Drugs A to Z, is available for us?
was a

-

Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

.

�</text>
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                    <text>September 17, 1970
Dr. H. C. B. Denber
Manhattan State Hospital
Ward's Island

New

m-VIV-

New

York 10035

Dear Hy,

Enclosed is the revised draft of the centrophenoxino study,
your suggestions included. would you like to send this
to the manufacturer, or to publish, or?

with

all

have been asked to expand our lectures in biological
lst year residents at Met. I would be pleased if
you would be willing to give one lecture (Fridays, 19-11 a.m.).
I have asked Dick Abrams, who is coordinating the schedule, to
call you for a suitable date and topic.
we

psychiatry to

Many

thanks.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

cc:
“wr-

Wr-r—rmmw-‘vmﬂvm‘vr

York,

one .

R. Abrams, M.D.

�</text>
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                    <text>m

Iw'mwvm

WWW”

September 17, 1970
Mr.

Earl Ubell

CBS—TV

51 West 52nd
New

York,

Deer

Street

New York

Earl,

While I was only able to see the first half of the series,
A to z, I was impressed that your text was a clear exposition of the state of our clinical knowledge of drug abuse. It
was a good job, and I am writing to ask whether a typescrlpt,
Drugs A to Z, is available for us?
Drugs

Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kt

�</text>
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                    <text>September 17, 1970
Dr. G. J. Sarwer-Foner
613 Cote St. Antoine Rd.
Montreal 217, Quebec
Canada
Dear Gerry,

Since returning from Europe, I have been swamped by reports
due and projects in distress, and find that I cannot attend the
October meeting. Knowing your history, the meeting will be a fine
one and I will regret not having participated.
My

best regards,

and I

trust

I

will see

you in the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

fall.

�</text>
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                    <text>”mug-wry . v-tu" ""‘y

r,

‘0 "mum-war:

_...

wr‘yivzvm'.“ wwv‘

rw:

September 16, 1970
Dr. G. G. DeAngclis

Pfizer, Inc.
235 East 42

New

Street

York City

Dear Dr. DeAngelis,

Please accept

my apologies for not appearing at the
I found that it would be very difficult to make the
trip today, I called John Kramer and his willingness to substitute
on my behalf made it possible for me to partially satisfy my committment.
I trust he served and that his presontation was acceptable. If he
did not tell you, he has been a student in my laboratories and I

symposium. When

pleaood with the work he has accomplished, particularly in
amphetamine research. Indeed, my presentation would have been a
am

distillate of his papers.

Thank you once again for your kindness in inviting
my participation, and I look forward to meeting you at the New York
symposium.
'

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>‘
,.

\\

g

‘

YR

,.

,vvmrgpu

September 14, 1970
Dr. Norman Pitts
Chas. Pfizer G Co.

Groton, Connecticut 06340
Dear Norm,
I have read with interest the proposed guidelines for evaluating
novel anti-anxiety compounds (received 9/8/70). Such an outline reflects

prevailing practice, but makes no effort to either justify the practice
as acceptable nor to highlight the hazards of our present practices.
As

on

a statement of present procedures,

special studies is interesting

evaluating methods

now

it is

acceptable.

The

section

and provides clues as to novel

under study.

Some specific comments are found on pages 3 and 4.
In the introduction, the marked paragraph may be omitted as gratuitous; and on
page 4, the section should be omitted since the NIMH—ACNP report is
and should not
a discussion of problems and issues, not guidelines
be so dignified, especially since the documents are not completed.
Would it not be premature for the PMA Committee to incorporate an
unpublished report before it is issued?
—

The initial single and multiple dose studies should be done in
paid volunteers, to assess safety and not in pagients (page 6).

qualities
that

is a statement that

would describe the steps
a potentially effective
trials,
The animal pharmacology which is used; the
(chemical and pharmacologic) of known anti«anxiety agents

What I miss most

leading to clinical
therapeutic agent.
seem common

and

criteria for

to this therapeutic group;

and

especially, those

For example, all
accepted anti-anxiety drugs are anti—convulsant, sedative (hypnotic),
produce seizures on rapid withdrawal and tolerance. But other
drugs have anti—anxiety qualities as various “anti-psychotic” drugs,
some anti—depressants, calcium salts and such,additional substances
as ethyl alcohol, opiates 33g,

aspects of present drugs that need improvement.

-

�Dr. Norman

Pitts

~.2—

September 14, 1970

In making these suggestions, I am reacting to the limited goal
of these notes - i.e., minimum guidelines for clinical assay; as
perhaps too limit33~?or industry. By broadening the document to
include animal pharmacology, criteria for early identification, and
suggesting that the drugs are symptomatic (therefore, not easily
categorized), PMA may highlight the complexity of the issues and
minimize the utility of 1970 issued, rigid ”guidelines”.
I am also concerned with the lack of supporting citations for
of the introductory statements. A detailed, academic presenta—
tion would be a more powerful statement.

many

Thank you

for the opportunity to read this

document.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>wmervw-uwanw‘

:v-ItF.’

.rvmw

'1'.~—'

-s~

”awn-v

...

”WA”...—

-.x--,-':-I-r-r\-x-~IKY‘VA"II7

September

ll.

1970

Dr. Rafael.R. Gamso

Director of Medical Services
Narcotic Addiction Control Commission
1855 Broadway

New

York, New York 10023

Dear Dr. Gamso,
would be pleased to participate in the NACC training
sessions and can join you on October 15, or November 19,
conveniently
preferably at 10 a.m. The subject should most data
of our
and
laboratory
the
of
overview
clinical
be an
by NACC.
supported
in
antagonists
narcotic
research programs
A more jazzy title is the one used by Frank Field - ”Immunization
Against Drug Addiction".
We

A

more

detailed report

on

the clinical aspects of our

studies can be obtained from the project directors, Dr. Arthur
Zaks (naloxone and L-alpha-acetylmethadol) and Dr. Richard
Resnick (cyclazocine). If you wish their participation, they
can be reached at my office (5 E. 102nd St., New York, New York
10029).

Thank you

for your invitation.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>September 11, 1970

Dr. Adrain Eisel

East.St. Louis,
Dear Dr.

Ill!

Eisel,

Thank you for your kind invitation to address the
October 1.
St. Clair County Medical Society on the evening of
"Drug Abuse",
of
While I would be pleased to discuss the subject

is a religious holiday,
I find that the date selected, October 1, celebrations.
and I will have to participate in family
faculty,

Dr.
studying and

I would recommend another member ofin our
Arthur lake, who has many years experience
for this
treating opiate dependence, as a substitute
narcotic antagonists

If I

may,

has studied methadone and the newer
from
and may answer the questions of the members of the Society office
this
reached
He
be
at
can
thh vantage point of experience.

evening.

He

or at 212-360 6748.

would also suggest that his expenses and an
honorarium of $150 would be apprOpriate.

I

is

thanks for your invitation; and if my suggestion
another
unacceptable, I would be pleased to visit St. Louis again at
Many

date.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>m—m

WW.w-m-.~._—w

-..

71

&lt;w"

A

“muwmw

September 10, 1970
Irrr—Jw

rum—“Wm“-

Dr. Norman

Dear Norm,
The doxepin pamoate

ww‘wwvl'v-v‘

~u-

2-w-wwrwwv—mmm-vvu-«w

W.

Pitts

Chas. Pfizer G Co.
Groton , Connecticut

protocol

was

revised following our

interesting discussion. I also found it advisnble to revise the
doxepin EEG report (IV: 7~21-70), 1 copy of which I gave you.
Please substitute the enclosed page 13, as revised, for the

page

is

5:1,

and no ”purer" doxepin

I was

your copy.

other preparation of doxepin has isomers in a ratio of
is aviilsble. For more refined isoner,
referred to Pfizer, Inc.

The

It was a pleasure to have you
expedite our studies this year.

visit,

and I

trust

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

we

can

�</text>
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                    <text>w-

I'd-“Yi'ﬂ’v‘

CW?

....

_

v.9

'Im'wu'v

'r|:\&lt;':‘-V'

«unww—MWY—

«yum ‘7’
.

_

Y,

._.,..,

_~-.

..

.IV-‘yﬁv"-n

new

«Vaultsv‘

.

..

September 10, 1970

v“

VIP-"Wm“

....-.-..wr. Fm

Dr. William Tabor
Robins

A. H.

1407 Cummings

Richmond,

Virginia

23225

n—rv

y-u-uwv‘uw',

mw-w

Bill,

Dear

I have read the protocol of AHR 3000—E (butaperazine) dated
6/10/70 with interest, and believe we can participate in the
assessment both of the bioavailability and therapeutic equivalence
of BPz tablets and concentrate. I find one serious problem with the

design.

'"W'JWII.

:-

.wvwns-w—wwarw-m-v

'v"

“wavy.-

'1
‘

$1:me

for

it, each subject is to receive tablets SP:
transfer directly to concentrate BPz, at the
dosage as tablets BPz. The assumption is that the equivalence
As I

WV'VX‘I'I'Fﬁ'AHWW'm

6

same

understand

weeks and then

of the

two formulations will be assessed by the continued improve~
nent of the patients.

Such a conclusion is valid only if psychotic patients deprived
of active antipsychotic medication would uniformly relapse on drug

withdrawal. But such is not the case, and on cessation of antipsychotic medication a number of patients may maintain improvement
for many weeks after withdaawal (see Gottschalk gt_gl;, Comp. Psychiat..
11: 123-140 (spec. pg. 135]; Kamano, Psychol. Rep., 19: 743-749. 1966;
Gittelman et a1., Psychopharmacology A Review of Progress. 1119-1154,
1969). Thasy“f? patients treated for 6 weeks are given placebo, not
all will relapse within the next 6 weeks.

this reason,

that the patients randomly
concentrate 8?: first; and for those who
stabilize in 6 weeks, transfer to the other formulation for a
second 6 weeks - avoiding the objection raised in my mind.
For

receive tablets
““mr.1i1-v

My
-

BF: and

I would suggest

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

up-

u.

“4..

..w--

�</text>
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                    <text>n'wAv‘W-w'v

"muv Wu"! aw-nmr

”WWW”

w. .‘s

Hwy—m u

mew—i

"7“... r—‘W‘wl-..u.-~.-.~.m.

.J.

_

w»

...vvm..,,-._._.m_m

_..,,,.;........,

.

v

.-.

7.-"

,_

September 10, 1970
Dr. Philip Tannenbaum
Smith Kline and French Laboratories
1500 Spring Garden

Philadelphia, Pennsylvania 19101
Dear

Phil,

I must ask your indulgence in correcting (for the second time!)
the summary and conclusions of our report, "EEG Profile of Oral Doxepin"
(IV: 7-21-70). Enclosed are five copies of the revised text which
should be substituted for page 13.
The change is occasioned by my doubts that doxepin can be fitted
into the 1969 classification scheme, and I am considering further
studies to clarify the data. It will allow me some flexibility in

the development of this classification.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

enc. (I)Revised

PG. 13

m.

.

..

.

..._

...,,..

H

‘

.,

�</text>
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                    <text>September 8, 1970
Dr. Monique Broudy

Division of Narcotic Addiction
and Drug Abuse

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Dr. Broudy:
I am writing to request an additional supply of marijuana for
our experimental program supported, in part, under NIMH 13172 and
13358. We have recently completed one study of marijuana and
perception in volunteers. A copy of the interim summary is enclosed.
In this study we used 46 Grams of marijuana, and have 54 Grams
remaining.
‘

In the next study, to begin October 1, 1970, we need 80 Grams
minimal. and would prefer 100 Grems to account for repeat sessions
and dropouts.

request an additional 50 Grams of the same marijuana, 2-PF;§1
(Mexican female, 1969, A9THC81.5% and cannobidiol, 0.12%). If this
is unavailable, we would ask for 100 Grams of equivalent material
and return the remainder of 2-PF-Bl.
We

As we have had recurrent difficulties with our nail,
request that you ship these supplies registered mail to:

Dr.

Max Fink
P. 0. Box 269
Great Neck, New York 11022

Thank you

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

may I

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                    <text>September 8, 1970
Dear Josh,

Enclosed is a proposed subcontract for the Athens
study. I have taken the model suggested by Mr. Graduall, and added
the modifications that I believe would cover our specific problems,
expenditures for personnel and volunteers in Greece. I have also
decided to append a full copy of the general provisions, some of
which apply Specifically and the others should provide some
evidence of NIH intent for anyone interested in reading them.
I would anoreciate your calling me at my office if the
changes are minor; and if major, I would appreciate yourrmaking
the appropraite amendments and I will send a messenger to pick

up

the corrected text.
Many

thanks.
Sincerely yours,

Max

Fink,

M.D.V

�</text>
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                    <text>September 4, 1970
Dr. Sidney Melitz
York State
722 West 168th

New

New

Psychiatric Institute
Street

York, New York 10032

Dear Sid,

pleased to nominate Jan Volavka, M.D. for membership in3 the
Society of Biological Psychiatry. I have known Dr. Volavka for
and
years. He trained with Jiri Roubicek, Creutzfeldt in Munich
and
psychiatrist.
Scott in London. He is a fine electroencephalographer
I

am

Roubicek
My

is

a

logical seconder.

best regards.
Sincerely yours,
Max

Fink, MD.

Professor of Psychiatry

Mszt
0110.

�</text>
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                    <text>r___.__________________________
g
,

E

E

;

Septeaber 4,
Dr. Ralph Dudley

1970

Mlller

Research Associate
Vanier Building, Nopean St.
Ottawa, Canada

Miller:

Dear Dr.

at Dr. Mira: last Saturday, and again at your
you were not too dismayed by the disparity of
of the reconstruction of the Miras' laboratories and

I missed you

hotel.

I

the state

trust

his ebullient optimism.
You

report.

Many

full

and Heinz mentioned the availability of the
I trouble you for a capy?

May

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psy. iatry

Max

Mszt

'

LeDain

�</text>
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                    <text>September 4, 1970
Dr. Finches Borenstein
Hopital Psychiatrique de

71, Quai Branly
Paris VII, France

Villijuif

(Seine)

Dear Pinchas,

I missed you in Prague, hoping to see you again. The
meetings were quite interesting, although too large with too
many simultaneous sessions.

Recently, I became interested in sulpiride when a friend
mentioned your studies suggesting that this compound may not
As you know, I am most interested
fit the EEG classification.
EEG
studies in new drugs, and I am writing to ask
in continuing
you would favor me with some data. Hey I have any recent
if
summaries of your work with sulpiride? In what cases do you now
—

find

it

useful,

and

at

what dosages?

are the profiles of sulpiride in patients?
volunteer data been reported?
What
Do

you think another

I will be graterl
wife and associates.

EEG

study

may be us ‘ul?

for your advice.

My

best regards to your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

Has any

�</text>
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                    <text>September 4, 1970

Peter Hales:
Ilnd Clinic of Neuropsychiatry

Dr.

Balassa—u 6

Budapest VII, Hungary

Dear Dr. Halasz:
I

regret

to Budapest

we

came

did not meet in Prague. Your
too late to allow a change in

letter of invitation

my

plans.

In the absence of a visit, may I ask that you send me a statement
activities,
of your interests, description of your hobbies and cultural
of
me
names
the
would
give
you
Also,
political iffiliations, etc.?
them
ask
to
may
work;
who
you
describe
or
can
your
three referees
write directly to me. I know Dr. Boszormenyi and perhaps you could
obtain a reference from him.
I look forward

to hearing

from you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 4, 1970
Mr. Harald Olav

Siegrist

District—Attorney

Witikonerstr. 468
8053 Zurich, Switzerland

Siegrlst:
Enclosed is a transcript of the NBC-TV program you requested.
pleased with your interest. I returned from EurOpe last week

Dear Mr.

I am
where I found much concern with drug abuse, including heroin.‘ This
tragedy which besets our nation, seems to be contagious for Europe.
Hopefully, our efforts will be supported here and successful in a

short time.

Sincerely yOurs,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>.

"a"

m

W-m.muvww.m.

.

«71171; rams:

W.w

.

.

.

r

'

.

war". wry

«

-

wax-r

l-"WWW

'c—Iw—qm‘r‘r‘

V-

September 4, 1970

—‘

Mr. Thomas Stevens

Hi-Tor Apartments, Apt.
Haverstram, New York

14A

Dear Tom,

regret your decision to leave us, but am pleased
that your special experience in narcotic addiction will not be lost
to New York. It is our fate to be a proving ground for personnel
moving to the NACC programs, and both Dr. Freedman and I are pleased
to be able to contribute in this indirect way.
My best wishes for your continued enthusiasm for your work, and
for your success in your new association. I think you for your
interest, enthusiasm and extensive efforts on the behalf of our
patients and programs.
I very much

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>-'

“17 war”..w-vw .

.

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"

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,.

v
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mt.

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up... _, w. w,_n_»mwylw.,_,,., v

September 4, 1970
Dr. Adam

J.

Krakowski

International College of Psychosomatic Medicine
Plattsburgh, New York
Dear Adam,

m...

nvmw

sea-yr.-

-.-.-v;

-.

interested in your suggestion to support the Inter—
national College of Psychosomatic Medicine; but as is generally
true for our academic programs, find no funds available to send
our staff to foreign meetings. As I am unsure of our participation
I

am

in Mexico City, I must decline your kind invitation.
It was fun discussing the Academy at the Pfizer symposium.
My

best wishes for the success of the

ICEM.

Sincerely yours,
Max
.

a
31‘

‘z=-':—:.c

“’r

.x
_..

1,,

n.9;

7
:.‘._.

rw’w—‘VW-

—.

a
:

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:1

v

13,—ng-

xmﬁ'ﬂVwrm-rlrW-vwwqqqm

run“

Fink ,

w).

Professor of Psychiatry

u—ywwp

MF:kt

�</text>
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                    <text>September 3, 1970
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Deer Turen,
You organized and ran a most interesting and stimulating meeting.
Most important, I admired your keeping your ”cool” despite Iany extre-

ordinary pressures, including the cholera scare: Congratulations!
Al has told me that the Friday session was most successful and I
I
specielly regret massing that. My trip to Athens was necessary, forhas
found that the estimated costs for this study (like so many others)
doubled in a year and I must negotiate once again with Washington.
I know you have had extraordinary expenses in your meeting.
Enclosed is a contribution in support of your meeting, which will in
a small way indicate my enthusiasm for your efforts.
My

best ﬁersonel regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

mf

�</text>
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                    <text>September 3, 1970
Dr. Paul B.

Briet

Schoutenburgst. 32
Oegstgeest, Holland
Dear Dr.

Briet:

pleasure meeting you in 033. I have discussed your
qualifications with the Department Chairman, and found him receptive
to my suggestions. Unfortunately, your curriculum vitae (description
of academic experience) has not arrived.

It

was a

still interested in working with us, may i suggest
a request for appointment, specifying the dates available,
and 3 copy of your curriculum vitae.
If

you send

My

you are

me

regards to Dr. Michelse.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>September 3. 1970
Dr.

Pierre Etevenon

2 Rue

Paris

D'Alesie
14 ,

France

Dear Dr. Etevencn:
Dr. Simon introduced us in Prague. and I am writing to ask
thct you send me such preprints of your studies of computer analysis
of 886 changes with drugs as may be available. Separately, I am
sending you cepies of our recent studies.

I trust you will
United States.

visit

us in

New York

on your next

tour of the

Sincerely yours,
Fink, M.D.
Peofessor of Psychiatry
’

Max

MP:kt

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