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                    <text>dawn-7w

April l0, l970
Commanding Officer
365 General HosplTal
iOO NorTh ForesT Road

Buffalo,
Dear

New

York

Sir:

This leTTer is in supporT of Dr. Zaks’ requesT To be
assigned To ForT HamllTon during The April 25 Through May 9
reserve Training period.
Dr. Zaks is involved in The TesTing of several drugs
in The TreaTmenT of nercoTic eddicTion. These are poTenT
agenTs and iT is imporTanT TheT These paTienTs be closely
moniTored. The assignmenT of Dr. Zaks To a feciliTy in The
New York Area would allow him To deal wiTh any problem siTuaTions
TheT may arise during ThaT Time lnTerval. Because of The complex
problems ThaT may arise during The TesTing of new drugs, iT is
necessary for The DeparTmenT of PsychiaTry To have available
Dr. Zaks experTise in This area.
Or. Zaks' assignmenT in The New York area would be The
soluTlon To a difficulT problem ThaT we would oTherwise encounTer
aT The DeperTmenT of PsychlaTry of The New York Medical College.
Thank you for your serious consideraTion of This maTTer.

Sincerely yours,
Mex

Fink, M.D.

Professor of PsychlaTry
MF:kp

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                    <text>April

10 , 1970

Dr. Jonathan 0. Cole

Boston State H05pital
Boston, Massachusetts 02129
Dear Jon,

After your telephone call, I asked Dr. Volnvka to check
on the question of hyperbnric oxygen and EEG, and the following
are his notes:

literature deals basically with two aspects of the
problem: oxygen convulsions and the therapeutic use of hyperbaric oxygen. The most recent work on convulsions (Morel,
Kerom and Levy, 1969), apart from asserting that the seizures
have a random origin (at least in the rabbit), also provides a
useful survey of the older literature.
The

Therapeutic hyperbaric oxygen effects on

were reported
by Levy-Alcover gt 31;, (1965), Marinchescu and Poilici (1966),
and Goulon et alt (1968). In patients with cerebrovascular
diseases, hyﬁergaric oxygen caused widely heterogeneous EEG
changes (either some flattening, or an amplitude increase, or
sharp elements) and this was interpreted as indicating that
oxygen might have resulted in cerebral vasoconstriction in some
cases. This would have accentuated any pro-existing hypoxia.
EEG

In London,iin 1966, a heterogeneous group of neurological
patients convalescing from brain anoxia or injury were introduced
in a hyperbaric chamber. I reviewed the records of 5 patients
and in this inadequate couple, saw changes reminiscent of the
initial stages of sleep ~ a lower of amplitude and slowing of
dominant frequency .

�Dr. Cole

The

April 10,

~2—

1970

references are:

Harel, D., Kerem, D. and Levy, S. The influence of
high oxygen pressure on the electrical activity of the brain.
Electroenceph. clin. Neurophysiol., 26: 310—317, 1969.
Dordain,

G.

Goulon, M., Levy-Alcover, M., Nouailhat, F. and
The BBC

clin. NeuroPhysiol.,

in hyperbaric oxygen therapy.
25: 90, 1968.

Electroencephl

Levy-Alcover, M., Goulon, M., Nouailhat, F. and Augustin, P.
of
study
patients undergoing hyperbaric oxygen therapy: first results.
Electroenceph. clin. Neurophysiol., 19: 608, 1965.
EEG

the

Marinchescu, C. and Poilici, I. ﬂyperoxic effects on
background activity in cerebrovascular diseases. Electroenceph.
Neurophysiol., 21: 95, 1966.

EEG

clin.

I

trust this is helpful.
Q

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

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                    <text>:~wW"m-cm‘n

&gt;--mlwwﬂ9‘wr'n‘va- ad‘Qw'rw.

vow-w:

‘u‘a—"ﬂ‘mw"

WW ,vw'ww :u- at

April 9, 1970
Mr. ﬁerman S. Weisman
Eeffman La Roche

Nutley,

A.

y-v

ﬂew

Jersey 07110

Dear Mr. Heisman,

.mp-

«pm—um”;

;
-

—

'v

Despite the outcome, I wish to thank you for the
your
efforts you have made in presenting our point of view tothat
the
proposition
to
accept
associates. It is difficult
there is a clear relation between brain function and behavior.
I hope that the data we are now presenting serves to change the
general point of view , that the EEG is a useless instrument,
and that more applications will be made, particularly in
psychopharmacology.

that we have already begun our
find a clear profile at 25 mg
to
failed
initial
chlordiszepoxide, but the changes at 50 mg are consistent.
You should know

survey, and

Again,

my

you

will

such a study will always be
come and visit at your

thanks for your kind presentation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

,

wan—«r

r

:-

participation in

I trust that
earliest opportunity.

welcome, and

,,

m;':—N;

Your

mfl

�</text>
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                    <text>TO:

Alfred

FROM:

Max

SUBJECT:

Fellowship Status, Dr. Jan v. Volavka

M.

Freedman, M.D.

DATE:

April 9,

1970

Fink, u.n.

Dr. Volavke requires two years training credit to achieve
entrance to the New York State licensing examination. One year
may be in psydhiatry, and the second in another clinical discipline,
3.5;, medicine, neurology or pediatrics.

For

this year he requests

an

accredited program in psychiatry.

Following our discussions, I suggest the following curriculum
which, if satisfactorily completed, should meet our ”training”

requirements.
1.

2.

3.

Course work - any of the following:
(a)

Introduction to Psychoanalytic Techniques.

(b)

Principles

(c)

Continuous Case Conf. in Group Psychotherapy.

Clinical Supervision

ﬁr. Wolherg

and Techniques of Group Supervision.

~

Dr.

c. welter-

Dr. E. Fried

Either of the following:

(a)

Individual psychotherapy,

(b)

Group psychotherapy

by Dr. Negler (and
Dr. Sadock (and

~ 1

2

cases, supervised

staff).

group, supervised by

staff).

Clinical Service.

Case management and responsibility for patients in one
of the following projects of the Division of Biological Psychiatry.

(a)

Comparison of

(b)

Anti-narcotic activity of

(c)

Child Psychopharmacology program

anti-depressants in
PCPA

subjects - Pink, Zaks.

PHP

- Finger. Simeon

in opiate dependent
~

Simeon, LaVietes

If these suggestions meet with your approval, I will try to negotiate
the details with the supervisors and clinics involved. I prOpose Dr. Volavka
be given credit for an academic year, 1970.
MP

:kp

�</text>
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                    <text>April 9,

1970

Dr. W. Keup, President
Eastern Psychiatric Research Association, Inc.

681 Clarkson Avenue
Brooklyn, New York 11203

Dear Dr. Keup:

In today's mail we have distributed copies of the EPRA
program as you requested. I plan to attend the meeting and
look forward to seeing you there.

Sincerely yours,
Max

Fink, M.D.

Secretary

�</text>
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“wwuy‘.«-mewovw-;www- mu.

.-

‘ q:

'

T__

i7

April 8,

,

.

1

m

1970

Dr. Arthur M. Sackler
William Douglas McAdams, Inc.
130 East 59th

New

York,

New

Street

York 10022

Dear Dr. Sackler:
Thank you for your interesting papers, presented before
the Second International Congress. The emphasis on alcohol
as a toxic substance is, of course, consistent with our own
experience.
We have tried for a number of
years to support the techniques
of antagonists in the treatment of opiate dependence and found
that political cooperation was very difficult to achieve. However,
the work of this department stands as the single most active unit
in the United States dedicated to studies of antagonists. like
cyclazocine and naloxone in opiate dependence. It is an interesting
story which has not been well told.

Again,

my

thanks for your comments.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
MP

:kp

-

va"

,

;

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                  <elementText elementTextId="103288">
                    <text>“mumw

7

v

,

,

'mwmmm‘mw

,

April 8,

1970

Dr. James A. Shield, Jr.
Branch

Clinical Resenrch

National Institutes of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Jim,
As

MH~15561~02

RE:

I discussed with you today, we have

great deal of data in our

out the proper

ECT

study.

statistical tests

of the college‘s computer center.

It is

we

collected

a

In order to carry
have utilized the facilities

understanding that these charges may properly
by the transfer of funds from Personnel
or Supplies to the category ”Other“.
my

be paid from

this grant

If this in in error, please notify

me.

Sincerely yours.
Fink, M.D.
Executive Director

Max

Mszp

cm" V,

�</text>
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                    <text>war-Fr.

April 9,

w...

~..

'R.'vm'r-rv

Dr. Milton H.

«”qu

.u—s

u

~

Chief,

Joffe

Drug Sciences

‘1‘

WWWvu-su—n-v mmwm-wmw. W"

w—w—rz—r-«w-n—v-v

1970

Division

United States Department of Justice

Bureau of Narcotics and Dangerous Drugs

Washington, D.C. 20537
w“.

e

Dear Dr.

Jeffe:

There are two programs relating to substance abuse in the
Division of Biological Psychiatry of this Department.

study program "Quantitative EEG Studies in Psychopharmacology”,
partly supported by MH-lSSSB is dedicated to determining the relation
of changes in brain fonction in psychiatric patients and volunteers
in response to established and experimental psychoactive drugs.
A summary of this work which has been continuous since 1954 was
published in 1969 and reprints reflecting this experience are
enclosed.
The

Our second program is dedicated to substance abuse, particularly
opiates and alcohol. This program is largely supported by a contract
with the New York State Narcotic Addiction Control Commission. The
focus has been on determining the clinical efficacy of various psychoactive drugs in altering the drug dependent state. We have published
our clinical results with methadone, cyclazocine, naloxone and tybanate.
Because of our interest in neurophysiology, we have applied the
techniques to our abuse studies and have reported the EEG changes
with methadone, cyclasocine, and naloxone.
Copies of these reports
and some of the preprints are enclosed.
same

.wwwg...‘

W'-‘l

-n—

;.-,m-rwmrv.

\
‘3

;
i
F

g
k
P

,

This program of research in substance abuse is new extended to
alleged substances of abuse, notably marijuana, hashish and THC. While
this work is unsupported, we are optimistic that the National Institute
of Mental Health may look upon this work with favor.

mwv u".-

�Dr.

Joffe

April 9,

~2~

1970

One of the special issues which has interested us has been
the pharmacology of heroin and methadone. We have utilized
intravenous heroin as a “challenge” to the cross tolerance of
methadone and the antagonism of cyclazocine and naloxone.

put this program in its proper perspective, you should
that the principal investigator of some aspects of this
nrogram is the Chairman of this Department, Alfred M. Freedman, H.D.
Me is also co~director of the Center for Studies of Substance Abuse,
another division of this Department, under the direction of
know

To

Professor Richard Brotman, Ph.D.
I

trust this information is helpful.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mﬁ:kp

�</text>
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                  <elementText elementTextId="105871">
                    <text>April 7,

1970

Dr. Joseph Zubin

722 West 168th Street
York, New York 10032

New

Dear Joe,

Enclosed

for the

My

1970

is a typescript,

proceedings of the

"CNS
APPA

Effects of Convulsive Therapy",
on “Disorders of Mood”.

thanks for your invitation and the opportunity to take

part in this interesting

symposium.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc .

�</text>
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                    <text>Mic—WW

r—w-zr-w—va—w- u—v .

.

wwwxw‘:‘l~.

m o—r‘w—

,

,

-

~

,

,

'I-u' mn’nvww'. "aw-v

0

April 3,

W mow
-

7-.“

\

1970

Dr. Ali Keskiner

”issouri Institute of Psychietry
5400 Arsenal Street
St. Louis, Missouri 63139

Bear Ali,

It was a
comments are
is

me

pleasure to read your application. and
hand-written in the text.

many

of

ﬂy

In general, the ideas are presented well and the argument

to

it

I found
repetitious
make some suggestions.

good.

in

some

parts.

which

inspired

is excellent, and the methods are clear. There are
The greatest
~ some are indicated in the margins.
weaknesses
some
weakness (and one that effected MB 11381) is in the initial selection
The aim

and testing of patients. It is not clear how the experimental
group will be selected, nor whether they will be drug free (did
I miss something?) and for how long.

I would also question your estimate of statistical and computer
costs. These are always much higher then estimated, and your
estimates are very low.
I wonder why you

omitted a

summary

you related it to am. this summary
drugs and special remedial training.

As

case summaries as

MS?

of the Stuart experience.

showed the interaction of
Or is she included in the

There are many subbestions for special therapies for schizophrenia.
But none are given in isolation, and combined therapies are the rule.
One of the principal assets of TRP was the control of drug therapy ~
and while you suggest

it

in the

test, it is not explicit

enough.

�I __,.

w.

wan-mm”

3"

«Wm-a

my.

y

‘.

V,

.-ww-

V

or. Xesklnor

W.

.

n... m. n WM...”

....

.

._,-

,r-

.nyv

.

mm W.

»

..

‘

H

.

,-

,

,

n

~2»

A...“ ...,._

.v

,

r_~

~

an

V,

‘1,th

rxiul-I‘wr 7,. .w-

April 3.

A

1970

All patients should receive standard medication, not experimental,
I am imrressed by Philip
plus romedial (or plus control therapy). ethasizing
the value of
Kay's hook on therapy of schizorhrenia, could be placed in the
combined therapy. Perhaps your project
same framework.

your
between this program
Finally, is there a connection
out.
be
should
spelled
Special aftercare? If so, it
of
The project is interesting, novel and a logical follow-up
command
attention.
some
should
the TRP. Within this framework, it
and

My

best wishes.
Sincerely yours,
wax Fink, W.ﬁ.

Professor of Psychiatry

Mszp

�</text>
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                    <text>April

2,

1970

Dr. William Tabor
Robins Co.

A. H.

1407 Cummings

Richmond,

Virginia

Bill,

Boar

Enclosed is our final report on AHR-IQOO. I believe it is
suitable for publication in Currant Thortpoutic Research and will
Such publication would
submit it, if you think it is advisable.
AME-1900
be
of
studios
useful
were planned.
furthcr
only
if
and

I have received the data analyses from tho Biometric Laboratories
separately I am sending a copy of their report and a duplicate

data deck.
We

and I

are proceeding with our fonfluraming roaction time analyses
will be in touch with you shortly.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MP

:kp

�</text>
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                    <text>April

2,

1970

Dr. William Tabor
Robins Co.

A. H.

1407 Cummings

Richmond,

Virginia

Bill,

Boar

Enclosed is our final report on AHR-IQOO. I believe it is
suitable for publication in Currant Thortpoutic Research and will
Such publication would
submit it, if you think it is advisable.
AME-1900
be
of
studios
useful
were planned.
furthcr
only
if
and

I have received the data analyses from tho Biometric Laboratories
separately I am sending a copy of their report and a duplicate

data deck.
We

and I

are proceeding with our fonfluraming roaction time analyses
will be in touch with you shortly.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MP

:kp

�</text>
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                    <text>~s

m,

Ayn—cram.

nu- . 4-,.

awn—aw

“1",!“m‘x ‘1'11'pPI1: rum“, wry-:15:tern-r.Mw—nﬁr».vrw'rwwuwmiw ' arnxs-vwwwmvmvv-w vr-vr-wnwvcm run-v

-

.

w.

.7..-

,Yr-I-v"

W"

at“

May

Dear

26, 1970

Everett,

Thank you for your invitation to participate in the
Duke symposium. As I mentioned on the phone, I am running a meeting
on Narcotic Antagonists in Opiate Dependence on June 4 and
I have
enough energy
will fly down on Friday, since I am particularly

if

left,

interested in the Saturday presentation.

Your paper submitted to the CINP is accepted in the
co-symposium on amphetamines, and will be presented on Thursday,
August 13 in the afternoon, I will be chairman of that session.
The main symposium will be held on Wednesday afternoon,
and a copy of that program is enclosed. While the Program Committee
viewed the sessions as separate, I convinced them to allow me to
one symposium~- which they agreed.
join the two and to call

it

For your program, I note that you have omitted the
neurophysiology of amphetamines as seen in man-- a small but important
distinction. If you plan to publish your proceedings you may wish to
ask either C. Shagass, T. Itil, Ian Oswald or myself to contribute
a small report or overview of the recent EEG [clinical data. John
Kramer has some EEG samples and data, and could augment his report

if

you remind him.

you.

Have a good

session,

and

I

hope

that I

may

be able to

My

best regards.
Sincerely yours,

W'm-‘wlv-—

~

.77“

r-

WWI—wwu-gr

'v
-

Vvy’yw'q—ﬁm'v—W

i.
.w

.m

,un-”

—:--—I

,

Ch “.195
Efﬂ‘kw'f‘.“a

"rnw-mt-F

'vm~

_

Fink, M.D.
Professor of Psychiatry

Max

join

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                    <text>wwwwwqmr—“n

-.

unrw-

man-

May

Dr.

29, 1970

J. Alan Burdick

Univereity of’Manitoba Faculty of‘Medicine
Winnepeg 3, Manitoba

Dear Dr. Burdick,

I have

considered your suggestion
of a chapter in your volume, "Quantitative EEG Analysis", and were
left with a few questions, the answers to which would assist us in
defining our contribution.
my

associates and

1. The chapter

titles already

2. Publieher and

approved and

their authors;

publication date;

3. The intended audience and the secondary audiencegand
4. the

contract specifications for contributors.

It would also be helpful for us to know from which point of
view the volume is being written, i.e., historical, technical (primarily
methode ?), applications, or ? ? ?
a volume.

I have

I

for your invitation. There is a need for such
recall that Paul Naitoh had planned such an effort and
Thank you

outcome. we believe such a venture to be
would
be pleased to assist in its development.
and

not heard of the

interesting,

Sincerely yours,
.4sz Pink, I403.

Professor of’Peychiatry

mﬁ/

�</text>
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May

29, 1970

Ellen Grass
Grass Inetrwnent Co/
Quincy, Mass.

Dear Ellen,

electroencephalograph will have been
I trust the smallthank
want
to
you for the loan of the machine
I
when I found my work overwhelming.

delivered safely.

at a

time

In checking, I find that I have used the various
the
supply package, and I wish to ask you to send me
parts of
the
use of the machine and these parts, shipping, etc.
a bill for
Again,

my

thanks .

Sincerely yours,

E

i

Max

Fink,

M.D.

Profesaor of Psychiatry

Mf/

.

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                    <text>P;

~ -

~

~

--

m-

.

-—u

«were

w».

7-

—-.

"-w-zw-van-WJ;

xrv'rm"r&gt;mv -.-

~

Wﬂ'nmi'ﬁ'v um-nw..¢~mv.

r3!

wmmml’i-VW'9Cwmyuwirm'w-qu—mn.

May

i.

.

»V.-.
--

.
sung-u--

~

. A..

rV

m... W,

wwa .

,
,.—

Y.N.—p.m-v.m—- wran— m.

25, 1970

W,

Dear Arnie,

’I‘"W:'Y-N.1"w-fr;y-n-

;

?

*

Enclosed is the formal acceptance of your report
Amphetamine Metabolism in amphetamine psychosis for the CINP in
Prague, as well as the registration materials. If you have not filed
these before, it may be helpful to do so promptly, since a visa
is required for admission to Czechoslovakia, and the room situation

is not like

.

g

Miami Beach.

Please note that the Program Committee wishes to publish
the reports and ask that 2 copies be submitted at the time of the

presentation.

Many

é

thanks for your

participation,

and

best regards.

my

Sincerely yours,
Max Fink, M.D.
Chm, Symposium

mf/

4,

CINP

ﬁn...

�</text>
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'V'Ff'nwu-n m»-5 qua-um

av

_

.

.

r
w ‘wnw‘w-4
. vmr—w—W
hwrﬂvt'wi!WIW~4"mw-WJPw-w-rgnwywwuw.m,k.,m,-v.,n;....~

pm

.

,

.

May

”W.

.

.

.,

,

"u

T.

26, 1970

Mr. Jonathan Coven
BA

Humboldt Ave.

Providence, R.I.
mgr.—

Dear Mr. Coven,
"IV-4.54““

..

‘-n‘n—

wmww—w—w

manure“

Your

letter

23, 1970 was received and I have
with the Chairman of the Department. We are

of

May

discussed its\contents
pleased to have your interest in the treatment of opiate dependence
with naloxone. It has been difficult to obtain supplies and the
studies are not ongoing at this time, due largely to the lack of

supplies.

part of your letter contains

general
using
approach of embedding chemicals in a silastic
research
chemicals
technique
of
a
is
such devices for the slow delivery
the
occasioned
by
reports that
of wide applicability. Our interest was
New
York
was attempting to develop such a deliv—
the Population Council of
ery system for birth control agents. The similarity between their
problems and our own led us to investigate their techniques and to
use their consultants as our own.
One

Good luck

error. The
membrane and

an

in your studies.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

.whym

u

were——

�</text>
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                    <text>May

26, 1970

Dear Oldrich,
Symposium

I believe I have carried out each of your wishes for the
4, and I am delighted with your cooperation in the matter of

the co-symposium.
As

I understand

and Ladwig, sending them the
have already registered.

it,

I have written to Drs. Griffith, Friedhoff,
assume the others

registration materials. I

I have written to Dr. Bradley about the support, and as I
have not heard from Dr. Davis, assume he needs no
support. I will check
again, but if you do not hear from me in 2 weeks, assume he needs none.

I have reminded each of the participants that their reports
are due for publication, at the time of the meeting.
I plan to have a meeting with the participants before the
will ask you, in Prague for a suitable restaurant or
meeting place, where we can discuss and plan the meeting and also
become better acquainted. I would be delighted
if you will find the
time to join us. (The evening of August 11 or luncheon August 12 ? )
symposium, and

symposium

(I have

assumed

Keep up

the

that

after your letter.)

Dr. Ladewig

good work.

will present in this

I look forward to seeing you in Prague.
Sincerely yours,
Max

Fink,

M.D.

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                    <text>Nay 26, 1970

Dr. Fini Schulsinger

medical Director

Konmunhospitalitet

Copenhagen, Denmark

Dear

Fini,

It

we have written, but I
friend, Dr. William Karliner,
summer is is interested in visiting
some of the facilities . Dr. Karliner is an expert in convulsive
therapy and has an extensive clinical practice with chronic

has been some years since

writing at the request of
who is visiting Denmark this
am

a close

schizophrenics and the acute depressive psychoses. Would it he
possible for him to visit your facility and meet with anpropriate
members of your staff ? He plans to be in Copenhagen about August
(Wm. Karliner,
1749 Grand Concourse, Bronx, ﬁuw York 10453)

7 ?

I keep hearing good things about your program~ in part
from Jan Volavka who hears from Mednick, and in part from Seymour Kety,

has presented the findings of your studies widely. Last I heard
Sarnoff was planning another decade of study plus an adventure ior the
Who in Hauritius. I hope these go well.

who

studies continue, focussed on EEG and drugs-— now
the narcotics, cannabis and their antagonists, as well as the special
problems of ECT. We have become the local experts on the narcotic
antagonists, particularly cyclazocine and naloxone, and have even been
asked to plan some studies of cannabis in Greece. (These are unrelated
studies, but there is a great overlap in the funding of the narcotics
and cannabis). Volavka seems to be enjoying his work although he is
Our own

concerned about

life in
is

New

York.

and in college and away from home. The
girls, 12 and lé are doing well in school . Martha is teaching first
grade and seems to enjoy it very much.
ﬂy son

now 19

about calling us the next time you are in New York ?
My staff would love to hear about your studies first hand, and I will
be pleased to arrange a seminar. Please call.
How

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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              <elementText elementTextId="43463">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="105877">
                    <text>Humvr'w-x-vvauvn—

_,

"wrwwrw

,.

,..

WV”

n

n

a“. W.w.r:,~.q¢;.~“

nulw

«

«canvas:

mwﬁw-mwvn“—0..“ W... «ems-1m“

,u~.vm.:».‘.;,r-.ym;

-

«MW

May

Dr.

mvru "a.

. wuv..~

y—wwv-

«y".-

.0"?

-u,w.,»n-,,..:,~u‘ mfg-,m-ww-rww

26, 1970

Philip Bradley

The Medical School

Birmingham, England
Dear

Philip,

Dr. John

The only nominations for Symposium 4 support are
Griffith, $400 and Dr. Ian Oswald,_$200. The other

participants have not asked

and I have not

offered.

If additional funds are available, I would appreciate
the opportunity to meet with the panellists and hold a pre-meeting
Such is best done about a meal and I may,
ask your indulgence in Prague.

session.

tight,

if

funds seem

Ivy-:1"

MW

"WA

the

I look forward to seeing

Duke symposium.

w—

My

m-

you in Prague,

if

not earlier at

best regards.

..

Sincerely yours,

“arm—l'nxmvr.-.'n

m:

‘ww—;

Nun—um

»

r

rnr

Mm;-

any;

.—...,

awn-aw»-

-w

~&lt;~w¢mz~w~w~a

r—s-xa-

vr-

Max

Dr. John

Griffith,

M.D.

Department of Psychiatry
Vanderbilt University
Nashville, Tennessee

Fink,

MUD

Dr. Ian Oswald

Department of Psychiatry
Royal Edinburgh Hospital
Edinburgh, EH10 5 HF, Scotland

._ .m

‘rw

w,

�</text>
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              <elementText elementTextId="43472">
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                  <elementText elementTextId="103294">
                    <text>'WI-"HW-‘u-

-

VII-FKW—v—wzmi-‘ﬁ1) we

~

.

.

.

,

,

May

.

“mummervww

26, 1970

Mr. Jonathan Cowan
34

Humboldt Ave.

Providence, 8.1.
Dear Mr. Cowan,

Your letter of Key 23, 1970 was received and I have
discussed its contents with the Chairman of the Department. We are
pleased to have your interest in the treatment of opiate dependence
with naloxone. It has been difficult to obtain supplies and the
studies are not ongoing at this time, due largely to the lack of

supplies.

error. The general
part of your letter contains anmembrane
and using
chemicals
in
a
silastic
embedding
approach of
research
technique
chemicals
a
of
slow
is
the
delivery
such devices for
that
the
occasioned
by
Our
was
reports
wide
interest
of
applicability.
deliv—
such
a
New
develop
York
was
to
Council
attempting
of
the Population
One

their
ery system for birth control agents. The similarity between and
to
techniques
their
to
and
led
own
us
investigate
our
problems
own.
use their consultants as our

“nu-"w"

Good luck

in your studies.
Sincerely yours,

;V;€Y-F”—-rV-V4'-'

.
air

m-wa—

Max

.
.7

rm

'yvrm.

GT.

m

1'~m

mnwrww

W

”a.

mm

.

«Us:

_.-y—.w.wm

Fink, M.D.

Professor of Psychiatry

yew-amp“:

mf/

�</text>
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                  <elementText elementTextId="103295">
                    <text>“rip—w»

n...

--

,

I‘KIVYVHVF‘4‘WJ“.

.

«v- -.

vrrwv,» q—w‘, Awfw\«

("f-S. ti”‘;.mm'-Ir_-u—xmw'ﬁ'.
"Wz'rs; v..."

May

25, 1970

Dear Dr. Ladewig,
and

it is

final details of the CINP symposia are now completed
understanding that you will present a report, Amphetamine

The
my

and Hallucinogen Dependence in Europe, as a joint presentation with
Dr. Battegay.

I am enclosing the application forms for registration
at the meeting as well as the formal acceptance of your report for
the Program Committee.

Please note that the Committee has requested a written
for
paper
publication be submitted at the time of the presentation.
I would like to accommodate the Committee and am asking each of the
participants to cooperate.
I lookeforward to your presentation and to meeting
in
Prague.
you
My

best regards,

and

my

thanks for your cooperation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Chm,

mf/

Session 4,

CINP

�</text>
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..

v...“ or... .9.» awnwwu

’

&lt;anr-nnm

May

hiss Janet

25, 1970

Swanson, R.N.

Division of Nurse Education
New York University
New York 10093

.

Re; Daveeda 8. Ross

L

.

Dear Miss Swanson,

I

am

pleased to submit this

for additional nursing training at

New

letter recommending ﬂies Kass
York University.

Miss Ross joined my staff early in 1969 and undertook
special training program in electroencephalography. She soon became
experienced in this technique and exhibited sufficient independence
and interest to asSume responsibility for studies in normal human
volunteers, In these studies, normal subjects are given novel
psychoactive drugs and the nurse (technician) and an assistant record
and evaluate the behavioral and physiological effects of the drugs.'
In these studies she has acted very much on her own and has yielded
interesting and reliable data.
a

'

She has also assumed responsibility for a drug evaluation
in anxious psychotic patients, completing the usual evaluation forms
and maintaining records, interviewing patients and summarizing the data.
In both these activities she has shown a sensitivity to small behavioral
changes and maintained good relations with the subjects, patients and the

staff.

Daveeda is a cooperative, pleasant, enthusiastic and bright
nurse. She has made important contributions to my programs this year,
and I would be reluctant to.lose her participation. I recommend her
highly for additional training, in the anticipation that I will be
able to enlist her assistance in my programs in the future.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
mf/

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                    <text>May

21, 1970

Dr. Jerome Levine
Chief, Psychopharmacology Research Branch
National Institute of Mental Health
Chevy Chase , Maryland

Ref:

101
(MI-i

13353-04
13172-01)

Dear Dr. Levine:

writing to request a re—allocation of the funds
to allow the purchase of the IBM 1800
now
on
a rental basis at this center. This request
system,
requires no additional funds from NIMH end will make
this facility available for continued EEG analyses in

of

I

MH

am

13358-04

psychopharmacology at the annual cost of maintenance.

Specifically, we request the transfer of $71,000 from
the category ”Other” to ”Equipment,” thus reducing "Other”
to $10,000 and increasing "Equipment" to $77,500.
This total purchase price of our system, based
credits for rental is $136,945.

on

the

additional funds are available from NH 18172,
allocated fer equipment to process
the studies of the neurophysiology of cannabis. Purchase of
the 1800 will permit the analyses of the cannabis data
for a $3000 annual maintenance charge.
The

where $48,000 has been

�-

2

-

balance of $12,000 is available in funds of the
Department of Psychiatry and their allocation to this
project are approved by the Chairman, Dr. Alfred M. Freedman.
The

This proposal will make the equipment available to
these study processes beyond the period of MH-l3358. In
the event that these programs are discontinued the equipment

will

be

available to

NIMH

for other scientific applications.

discussed with you, we have carefully assessed
other instruments, notably the PUP-12 and PUP-15 which are
being recommended in similar studies; and while the initial
outlay is slightly less than the IBM 1800, the expense of
re-programming and the interruption in ongoing programs
make the approach to continued work less attractive.
As I

present rental cost is $4330/month. We are
predicating this request on an expeditious approval of
the transfer of funds, effective June 1, 1970 or July 1,
at the latest.
Our

Many

1970

thanks for your considerationaand patiente.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

cc: Dr. Robert Petersen

Chief, Ctr. for Studies
Narcotic &amp; Drug Abuse

ARPROVED:

Alfred M. Freedman, M.D.
Professor &amp; Chairman
mf/

Lorraine Lasker

Direcoor, Research Administration

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                    <text>"w—

...m W's: ‘ ,. "upg-. —~mzn~wmwu¢ror v-ry'r-m-h—rmmnmwm"

May

18, 1970

Dr. Stephen Bernstein
ECDEU Program, N.I.M.H.
5454 Wisconsin Avenue
Chevy Chase, Maryland

Dear Dr. Bernstein,

In preparation for the ECDEU meeting, I have read the
ECDE! studies finished and reported June 1969 to May,
of
the
report
1970. One one of our studies, that of doxepincchlordiazeponide is

listed.
w—

at least

period:
~vv-1Wmmau—m-ww

3

In discussing

this with

additional reports,

Dr. Simeon, he assures me

Form 22, were

that

submitted during this

Thiothixene in anxiety/depression

AHR~1900

in schizophrenia

Ketipremine-imipramine in depression.

Copies of those

to vou.

reports are enclosed,

if

the originals failed to get

rm"

In my recent telephone conversation, I indicated that I
intended to request a continuation of the program, MH—13358, "EEG and
Human Psychopharmacology" in two parts-— one focussed on EEG and another
on ECDEU in juveniles. The ECDEU application, "Psychopharmacology of
Juvenile Behavior Disorders" is now at our Research Committee and
should be in Washington by June 1.

not meet the June

1

The EEG program

application will

deadline, but will be submitted soon thereafter.

I look forward to seeing you in Boston.
Sincerely yours,
Max

Fink,

M-D.

Professor of Psychiatry

mf/

�</text>
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                    <text>J

v

r

,

‘

'rvgle7grA"IWT~7¢‘—n"2«vwf'

‘3?
.
:vhw'w‘r

v—w

May

Dr. Joyce
1315

W.

Shall,

16, 1970

M.D.

Tenth Street

Indianapolis, Indiana

46207

Dear Joyce,

and

I

It

was nice spending some time together in son
much
enjoyed your presentation at the SBP.
very

Francisco,

I am writing to ask you send me a copy of the letters
to)
Joe Bird of'Sterling Winthrop regarding cyclazocine.
from.(and
am
distressed
that they are discouraging testing of’this interesting
I
compound. I don't think I can do anything directly, but I do talk to
JOe Bird occasionally and I may be able to have him review his decision,
if I know the basis he gives.
at 58?.

Many

thanks, and

my

congratulations to Iver on his election
—

Sincerely yours,
Max

Fink,

M.D.

Professor of.Psychiatry

mf/

�</text>
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                    <text>-

«nu-mm"

-.v--

May

_&lt;-‘-.—.

Mr. E. H. Belter
The Addiction Center
2000 Domanik Drive

Racine. Wisconsin,
Dear Mr.

14. l970

53404

Belter:

Enclosed are copies of our recent reports on cyclazocine
in the treatment of opiate dependence. I trust these are

helpful.

Sincerely yours,

Max

Fink,

M.D.

Professor of Psychiatry

Mthr
Encl.

�</text>
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                    <text>nunsawv Wm—“

w—w w

'm.‘-1'1‘

,

-

,

May

:

}

‘

l

i

E

.W

,

“‘\.n.'~.

16, 1970

Mr. Max Singer
Hudson Institute

Croton~on~Fudson, N.Y.

Dear Max,

E

k

E

E

‘

r

l,

I have read the "First Draft of Final Report”, dated

interest, enthusiasm and some eventual disappointment.
Interest, because the report is well-written and some expressions(such
as the need for better enforcement against heroin) are clearly stated.
Enthusiasm, because I know the problem is urgent and any thoughtful

Hay

1970 with

approach should be listened to with care. Disappointment, because I
find the medical aspects treated tritely, even diffidently, and with
an immaturity that casts doubt on the value of the effort. Perhaps my
original doubts are re-enforced by this report. Let me give you a few
examples.
"Moreover, physical damage from even

protracted use of heroin

is rarely serious or irreversible.” (pg 16,par. 1); and, "Current addiction
. . . . is a dﬁseaee one can treat, and in most cases is not terribly
serious even if untreated." (pg 19, par. 2). What fatuous comments !
Death is irreversible, and death is an ever~present aspect of opiate
dependence. So is liver dysfunction and heart disease and post~traumatic
}

g

‘

brain disease. Your views of opiate dependence are the views of the
upper classes who rarely saw the dangers of syphilis or tuberculosis,
diseases of 'those other people', and therefore could say that they
were unimportant—~ until it affected their children. Heroin addiction
is a serious, fatal disease, especially among the young.

seems likely that many or most of those who take up heroin
are weal or immature personalities, perhaps psychologically dependent
types. It also seems likely that the addiction experience strongly

"It

reinforces the tendency tpvard immaturity, weakening the character of
those who might have been stronger when they began." (pg 19, par 1).
There is no evidence for these views, and they are eqyllly fatuous.
How

does

it

help to see the

ill

as "psychologically weak" except to

superiority. I suppose it makes you feel better, for after
not
addicted, therefore you must be 'strong' or have a
are
you
all,
'mature personality'. Come off it, Mr. Jack Armstrong, All—American
assert your

own

Nixon hero.

There is more. I am disappointed that we know so much that
research is not needed. I am delighted that there is little danger
of methadone spillage, especially if the delivery system is computerized.

more

-ps

�WI" We."

.

351w

-

mm,-

W

.

){ax

,

Singer OOOIOOIOOC-l-QOODOI...P8882

w

1W wmrmww:WH-+r

mv~w¢rmau~z("4" ‘W“&lt;:Vm"rm

COCOOOCUODOOCOOIOUBIay16’

It is valuable to

know that a methadone delivery system can be
and
indeed could eventually replace off~track
self—supporting,
as a source of state revenues.

"Wm—W

Remind me

1970

betting

There is some hppe in the future, I am glad to see.
to have faith in the democratic process, if does work.

"WWW.

v...

I

thanks for sharing this preliminary report, and
sure you will appreciate the candor.
My

WW...

am

..

My

Wmvvaum

best regards.

_-

--

Sincerely yours,

E

Max

Fink, M.D.

Professor of Psychiatry

[

mf/

P.S.

Truitt position paper on legalization of marijuana is
equally trite and superficial. The issue is not the medical
data on marijuana, where I agree we need more information, and we
are participating in obtaining the necessary data. The present crisis
is the disparity between the severity of the legal penalties for
marijuana use and possession and the complete lack of evidence of
any harm from occasional use (or the harsh comparison with alcohol
use and its prominent medical complications). The political issue
is in a relaxation of legal penalties for marijuana use and the
clear separation of its relative safety with the severe harm of the
The

opiates.

"1'

~.

w«unm.~n~vw~

many-r

�</text>
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                    <text>May

:4, l970

Mr. Gradwell

Confracf Managemenfs Branch
Naflonal lnsflfufe of Mental Heellh

540l Wes? Bard Avenue
Chevy Chase, Maryland
Dear Mr. Gradwell:

In response to your request To Dr. A. M. Freedman regardlng
confracl proposal for The sfudy of cannabls ln Alhens, we are
pleased To answer The two speclflc quesflons —! the role of The

The

lnfernaflonal Assoclaflon and a budge? breakdown.
Slncerely yours,

Flnk, M.D.
Execuflve Dlrecfor

Max

MF:kp

�</text>
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                    <text>May

Elsevlar Publishlng
P. O. Box

le

l4, I970

Company

Amsfardam, The Nefherlands
Genflemen:
The Aprll l970 lssue of EEG. clln. Neurophyslo|., Vol. 28,
No. 4, was received damaged beyond use.

"gamma"

If at all posslble

-

we

would appreclafe a replacemenf copy.

4pm.,

Slnceraly yours,

17.

.

”my-ﬂy

Max
my

v-v

.w-«u-nqn'

1'!’

Ayn-VI".

‘I'v'

-—-v

v

.mrvwn

W7:""‘(

11'

“war.

5:

run—nan”

1-H.

Y:-

NWMV’MA’VW

011””:me

:vv

wt».

.

'

.—

Flnk,

M.D.

Professor of Psychlalry

ryw—rrv

MF:kp

�</text>
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                  <elementText elementTextId="105883">
                    <text>May

Mr. E. H. Belter
The Addtction Center
2000 Domanik Drive

Racine. Wisconsin,
Dear Mr.
1n

14, 1970

53404

Belter:

Enclosed are copies of our recent reports on cyclazoc1ne
the treatment of opiate dependence. I trust these are

helpful.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

MF:hr

Encl.

,

.

Ham-1v

"JV—7r.

«,r'VV"

To

�</text>
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                    <text>May
7

,

arc-n...

u

ralY‘Zer-Ifr‘ﬁ

Mr. D. A. Geickle

Secretary, Commiffee

CMA

House

i3, i970

on lnformafion

'

|867 Alia Visia Drive
8, Canada

O++awa

Dear Mr. Geickle:
Dr. Lionel Soliersh presented anforcefui sfafemenl abouf

The changes in affifude on medical uses of cannabis in Canada.
in a discussion, he suggasfed l wrlfe To request copies of the
“Brief on Non-Medical Use of Drugs“ and The CMA Review and

Posilion papers, if These are available.
Many

fhanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF:kp

�</text>
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                    <text>T,,.

.14,

,_

“mm, ,

-~

NJn-na-nmnrrrw

mirrﬁh—iﬁwvm

wuaqﬁaﬂ

wwwwzmm»ww "W"

4, l970

Universily Clinic

Allan+a, Georgla 30322
Dear Cr. Skellon:

Enclosed are some of our recenl reprlnfs, including a copy
of fhe Q~scale reporl. The Techniques for cyclazoclne are
dascrlbed ln sufflcienl defail To be useful. Cyclazoclne can
be obfained from Sferlingnwlnlhrcp Laboraforles in Renssalaac,
York. Naloxone is no? available for Trlal.

New

You can ”lune ln” cyclazocina by using fhe scale and
lnducfien schedula, and as paﬁianls are in freafmenf, revlewing
fhese wifh us. We would be pleased +0 have you vlslf us, or have
one of us consul? wifh you in Allanfa if you wish.

Sinceraly ycurs,
Max

Fink,

M.D.

Professor of Psychlafry

"r.

1‘

.

Dr. w. Douglas Skelfon

Emory

'M.

v

.rrw,» “a“, ,.

May

«y-

.vwvnvx-my.

1,3;

NF: k5)
GHC.

�</text>
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                  <elementText elementTextId="103300">
                    <text>33?"

'3‘ wr-rvmmumu‘nmmn‘w.“ﬂ

-...-,

,

-

w

«lax-war

May

Dr. G. F. ﬁlana

Clinical Research
Rackiff

&amp;

Calman

4, 3970

Co—Ordlnafor

Dansm Lane

Hull, England
Dear Dr. Blane:
Thank ycu

for your reply

To my

inquiry about

SOBO—M.

are lndeed Inferesled ln Gaveloplng a long~ac+ing opiafe
anfagonlsf, and if some clinically usable supnlles of 5050~M ware
available, would be wllling To underlake or underwrife The Tesfs
nacessary for an lNDA.
We

I

am

no? acquainted wlfh 320~M, bul will Try To obtain lhe
which i presume comes from Dr. Seevers.

available dafa,

leek forward +0 gafflng logefher in July in New York and
ask fhaf you write as soon as your Trip plans are crystallizad.
l

Slnceraly yours,
Max

Fink, M.0.

Professor of Pchhlafry

Mszp

.m

.,r

awry-u

warms;

w

.A,

mum-nay”;

"fully”

A

.

.

*wzmmnnrr'“

�</text>
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                    <text>wx. ,..‘,. ('"rpum

May

Mr.

4, 1970

Harberf Sfurz

Vera lnsTifufe
30 Eas? 39+h Sfreef
New York, New York
Dear Mr. $+urz:

‘n reading The lafasT WHO reporf of 1+5 ”Expert Commiffea
on Drug Dependance”, concerning ifs l7fh mee?lng, Augusf 25~30,
1969, ! nofed commenfs which ara ralevan? To our lnfaresf. I
am Taking fhe liberfy of sendtng you fhe anglosed pages (24-26)
of who Technical Rﬁporf #437, Geneva, 5970.

Sincerely yours,
"an Fink,

#900.

Profassor of Psychiafry

Mmkp

enc.

�</text>
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                    <text>~

~wm-n-.v.mwvm"‘m-Wssmw may...

. “0.:

.m:mu.-, .‘wuyn—Ig J‘JI'WC'mmm-

.

-

,

7

May

u

g

,

.vur y'arth-‘g-Wg ;7~‘,.‘..W,»Wmlmn,— rvvv-v

4, i970

Dr. Maurice Seevers
Univarslfy of Michigan
Deparimeni of Pharmacology
Ann Arbor, Michigan
Dear Dr. Seevers:
in a leflar from Dr. G. F. Blane of Reckiff and Colman
describing sfudles wifh narcoilc anfagonlsfs, he menflons
320*M as an inferesilng cempound 3? Michigan Unlversiiy which
failed “To prolacf dapandenf monkeys againsf sympfoms of
morphine wlfhdrawai”. i presume the work comes from your
laboratory and would appraciafe your raferring This nofe +0
fhe appropriafe co-worker for any pre~prin+s Thai may be

available.
Many

+hanks.

Sincerely yours,
Max

Fink, ”.0.

Professor of Psychiairy
MF:kp

-x-.-—_

'.-‘:V

-

‘ni‘Vm‘mﬂ‘m'n

~

,
-..;,-

'v‘

u:.~muu.;.~—~,,vvy—«ww‘w-m.w:mmgmmvw

.v

,

.,.

.

�</text>
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                    <text>‘

ﬁ

f. ‘1

May

Dr.

W.

4, i970

Douglas Skeifon

Emory University Clinic
Allanfa, Georgia 30322

Dear Dr. Skelfon:

Enclosed are some of our recenf reprints, including a copy
fhe
of
Q-scale reporf. The fechniques‘for cyclazocine are
described in sufficienf defali To be useful. Cyciazocine can
be ob+ained from Sferling-Winfhrop Laborafories in Renssalecc,

New

York.

Naioxone is no?

available for Trial.

can "fune in" cyciazoclne by using the scale and
inducfion schedule, and as pafienfs are in Treafmenf, reviewing
These wifh us. We would be pleased To have you visif us, or have
one of us consul? wifh you in Allenfa if you wish.
You

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF:kp
GﬂC u

�</text>
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                    <text>ﬂay

i, |970

Dear fir. Refer: :
On

ihe advice of Professor Danlal Efren 0f fhe National insilfufe
i am
adﬂresslng lhls lefler f0 ask whefher your

of Manfal Healfh,

laboraforles

can produce

clinical quanfilles of Naioxono,

narcnflc anlaganisf, for our sfudlas.

a

Naioxone (l~n~aliyl~7,8-dlhydrn—l4~hydr0xynormorphlnone
hydrochloride) is useful in freatlng
dependence,
but The clinical irlals have been law,opiate
llmlfnd by an lnadequafe
supply. As l understand the problem, naloxona is produced from
Thebaine, and if is The prescription of lhls compound which
curfalls

producllon.
We

have found That 3.0

oral naloxone a day are naeded +0
and would lika f0 verify fhis
observation in a clinical lrlal. wﬁ need 2-4 kilograms naloxone,
and i am wriflng f0 inquire whether Maker Chemical
produca
lhls cempcund in fhis quanfify; and if 30, a? whaf can
and in
ccsi
whai lime. WE are capable of wrlfing a
contract
60 days,
wilhin
and wmuld hmpe lo d0 5G as soon as a bid is received. While
is on fhe narcoflc iisTs-of This caunfry, we have haen assurednaloxona
nf fhe necassary impart llcansas; and as fhls supply will
net be
sold, are assured of fhe coop@ra+lon mi The licensee.

sustain antagonism

i

To

Gms

cplafes,

look forward To hearing from you.

Sincarely yours,

m1wwarumw.

Max Flak, M.D.
Professor of Psychiafry

Mfzkp

cc: Dr.

A. M. Freedman
Dr. 3. Efren

“‘th-

r
-

7.-:I.k.-a

AIR LETTER:

Dr. Z. Rofen

Direcfor

Chemical Lfd.
6570

MAKOR

PO

Jerusalem, lsratl

f
my!

SW!)

15%

‘

-.-an

�</text>
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                    <text>.

l:

May

l,

i970

Dear Oldrich,
have received our proposed program, and I
has been accepfod. i am wrifing foday To ask your

By now, you

assume

it

approval of supper? for

pr

of The parilclpanfs.

Drs. Davis,

requesied supporf. Dr. Griffith
has some aid from his unlversify for his slay in Prague, but
Dr. Oswald requires
should be awarded $400 to aid his Travel.
Friedhoff

and Ladewig have no?

fare lo Prague,

and should be awarded $200.

Will you write To These men,

Philip Bradley?
Many

Thanks, and

i

or,

may

i, or

should

look forward #0 seeing you in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF :

kp

air

�</text>
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                    <text>WW‘Z’

:v-unv m .mrw-ww’.

"K‘Jru'n'.

mmquswnmW‘s—w.«a wr ywlm.""x’0wvn :
I ~

arm

“aux-.-

».-

nu ma: Iw-B'WF&gt;IS:- m. 1" V

-

.uuv.» vum-m-uuan

-

yws—u—w—v-wwww(.mqanryump-u;

(us-W,

v
r—‘Vy'rmx14‘r'nvvm‘w"~»~uw:w~.wn‘mxﬂ]uv""r“l.wvn‘

June 29, 1970
T0

WHOM

IT

MAY CONCERN:

psychiatric assistant

Mr. Robert Sharp was employed as a

in the drug addiction research program of this Department of
Psychiatry from October 1967 to April 1970.

During this period he assisted us in interviewing patients
with opiate dependence; supervised other assistants; participated
in group therapy sessions; and coordinated ward activity programs.
In these efforts he was diligent and reliable. He assumed
responsibility and carried it out.
he

left

us for personal reasons, wanting to be with family
I regretted his leaving, indicating that
California.
in
could have his position back as long as it was unfilled.
He

members

I

am

pleased to

recommend him

for

a

similar position.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>June 29, 1970
Dr. F. E. Shideman
Department of Pharmacology
University of Minnesota Medical School
Minneapolis, Minnesota
Dear Dr. Shideman:

I am pleased to recommend Mr. Peter Irwin as a candidate
in your doctoral program. Mr. Irwin has worked in this Division
since January 1968, and during those years he has assumed more
and more

responsibility, exhibiting industry, reliability

and

enthusiasm in a research program for
little training.
has learned how to record and process the human EEG; to use an
IBM 1800 digital computer and auxiliary electronic equipment; and
which he had

He

to record and analyze
In

assumed

human

behavioral data.

this work, he has been reliable

and capable.

He

responsibility for analyzing behavioral data of

has

considerable complexity and approached the problem with
interesting and novel methods.

I highly

his additional training,
without reservation.

recommend

to your program

and commend him

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

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June 29, 1970
Mr. George Griffenhagen

National Coordinating Council

Washington, D.C.

on Drug Abuse Education

Dear Mr. Griffenhagen,
Thank you for your kind invitation to participate in
the July 15 meeting at the Chalfonte Haddon Hall in Atlantic City.
As I anticipated, I will be unable to attend, and I have asked Dr.
Richard Resnick of my staff to present our data.
Dr. Resnick is an Assistant Professor in this Department
and has been a project leader responsible for our studies of cyclazocine
since 1967. He has developed a typology of characteristics predictive
of outcome in antagonist therapy, and has been able to deliver a full
cyclisoeine induction in 4 days with minimum symptoms. I am confident
that he will most ably satisfy the needs of the panel, and I am
sending him the material you sent me. He can be reached at the above
address or by telephone at his office (212 MO 2 1899).

Again,

my

thanks for your invitation to

this interesting panel.

participate in

Sincere;y yours,
Max

Fink,

M.D.

Professor of Psychiatry

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June 29, 1970
To Whom

it

May

I

Concern,

pleased to endorse the application of
membership in the Central Association of
Itil,
Electroencephalographers.
Dr. Turan

am

for

rue-m.

»

w"

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Anvme-H'mW-erw

mo:

v

I have known Dr. Itil since 1958, and have been closely
associated with him in his research programs at the Missouri Institute
of Psychiatry since 1963. In the programs which he developed
there, Turan has shown an unusual enthusiasm, ability and integrity.
His approaches are novel, and his technical ability exemplary and
impeccable. His work in the EEG effects of drugs, in sleep research,
as well as the applications in the special problems of therapy
resistant schiz‘phrenia and clinical effects of new drugs are among
the heat produced in this country in the past decade.
knowledge

society.

I

that

recommend

he

will

his application with enthusiasm, with the
outstanding contribution to the

make an

Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

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evsd 9W .srujui rsen ed: nl sidsiisve 5d IIlw vsdj 33d: {inﬁlinu at 31
Editav,nthgVRbeeerabahdpendsobnﬁ saute 33d: .Ylismroini .bselvhs need
Washingdbnbsbucanoo 21931330 rind: yd mergorq aid: 30 waiver ed: .3HOQUG
.9.1) aseu AGE 5&amp;3 to} bevrsesr ed bluoda snoxotsn in asiquue ed:
Dear Site 103 jsﬁrsm on 25w axed: scale and: bus 3(eeu Isrejnsreq .sjuos
antbuienl .msrgorq aidj 101 jroqque Iis .sonebnsqeb sjsioo at ﬁelnonenns
Q€591

I read thebaselinseofeﬂhbdbodprogedﬁqnnanaboxonilﬁniyeur 933
issue with some surprise and unease, for it is filled with
important errors. An earlier report, alleged to come from Washington,

June 24
was

(AS

aﬂiorltit‘d withe‘quoi‘s ow: n1 anion seed: gnljkiw me I
snub) Jroqsr aid: in soruoa 9d: Jed: Jeoggue 03 has .bsviovni asueei
annuoabe as: sbfzddoFueadsaddtddnnqtdsedr sndoaheinnsdvoiqthdn bns

Depardienﬂioﬁﬁlsydhilbri bﬂvthebﬁeldtdsbIﬂqétcoﬂJCubldgd,.ludanOIesggue

Hﬁbxoisn lo vanes 10? manorq ed: nnljroqqua ei obnﬂ Jed: aeliqml 310q91
.eetwrsdjo uiurj are 83953 ed: nsdw ,snnshnsqeb ensign almonds n1
2. The program for the study of neloxone is under our joint

directionﬁm ti sort-opporudonyzfnndsoosdchethlomdtitute of

Mental Healthdnvhd hiltigrostinoddestodcanannppsesed aseltbcsstedyslawsn
of antagonists was in 1968. Since then we have been supported by the
New

York State Narcotic Addiction Control Commission

of narcotic sntagoﬂisbs.rfsxsant?

in these studies

In the spring of 1969 we did recommend a program for
the development of a long acting naloxone in silastic vehicle to the
National Institute o£.ﬂendnldﬂeshth, requesting a contract. That request
has never recordedaﬂ iorsatesapiﬂ, although informally Dr. Cohen has
indicated that the Institute has another program that they are supporting.
3. Endo has an

they are awaitin approval.

NBA

for

Narcnn

for acute intoxication.

snd\3m

Since 1967, four investigators have received supplies of
naloxone for trial in Opiate dependence. Three have assayed more than a
few patients and these attended the conference on Narcotic Antagonists,
sponsored by the National Institute ofMental Health and our College,
held at the Academy of Medicine on June 4. It was apparent at that
meeting that more study was necessary before oral neloxone would be
useful in the treatment of opiate dependence. Suggestions that the data

for this application are satisfactory for

an

NBA

are premature.

�run——

.,, m

ave

.

l‘::'erV

‘

‘

-~‘~u.wnw

‘p

:np:

It

-

_

~

~

was the recommendation of the

,

u.

-

n'avwrqu rd—r'sﬁ' white:

"or

ulwmm’ﬁr

.

“.7”

rv.

investigators at this

meeting that further studies be undertaken, of the clinical applications
of antagonists (particularly naloxone and cyclazocine) with concurrent
attempts at the development of long acting forms, and trials of other

antagonists.

lnfortunately, supplies of naloxone for clinical trials
We requested additional supplies in December 1969,
and despite many proﬁﬁiﬂs,8€hoanthave not been made available, and
it is unlikely that they will be available in the near future. We have
been advised, informally, that since Endoahaaquthasaadﬂvgaidn.aﬁalbﬂ
DuPont, the review of this program by their officers concbudednbhgnldesw
the supplies of naloxone should be reserved for the NBA uses (i.e.
acute, parenteral use); and that since there was no market for aura 159a
antagonist in opiate dependence, all support for this program, including
the mklahilhbxodﬁnsnpphsaonhedurﬂeincubateded: baa-1 I
are in short supply.

djlw b91113 at 31 101 ,sesenu bns sslaqrue smoe djlw sueel AS snuL
,noigntdesw nor} anon on bogslte ,3roq91 retiree nA .erorrs insjroqml

I am writing these notes in two attenptsﬂjta bbdttfyoeha
issues involved, and to suggest that the source of this report (June
and tbdjptevhmkndpobns mamacbabhaabootﬁonlﬁda the accounts

asw

24)

Suggestcdnhbna,,bgbldnDtﬂlatbphidabﬂbu.ﬁduﬂivad QIOIIﬁerﬂeﬁorhnsﬂbcsqu

Endo is supporting the program for assay of naloxdﬂl
in chronic Ipiate dependence, when the facts are truly otherwise.
Inlet ruo rsbnn sl snoxolsn lo vbuje 9d: 103 mergorq 5d? .3
io azunnmﬁoD-npenausedthaootbenirquotuxamearing in tourmaline-11b
newsleqbevsaldjlaad biasedqlnGnI0303noﬁboctincrgfJﬁhd bﬂUthddlseH is3n9M
9d: yd bsjroqque 599d svsd 9w ﬂed: eonla .8891 nl sew ejelnogsins 30
eolbuie seed: at noteatmmoO IcijnOD nolsolbbA alioorsK 93838 ﬂxoY wsH
Sincer81y.)outaogsins alnoorsn 30

report implies that

101 margorq s bnemmoosr bib 9w QBQI 30 entree ed: nI
on: 03 elatdev aljaslle nl snoxoisn gnljos gun! a lo ansmqoievsb 9d:
jasupsr 35dT .3osrjnoa s gnljasupsr ,djﬂanHFilhseH.ho sjujlaenl Isnoljsﬂ

and nsdoD .1ﬂ vIIsmroinl dguodjls .thﬁcadonuof Estehiablx raven and
.Rnljzoqque are ved: 35d: margorq radions esd ejujljenl 9d: and: bsisolbnl

mf/bns .nolnsaixojnt ejuos to} nsozsﬂ :03

lo asllqoue bsvlsosr
s and:

even

AGM

arojsgljaevnl tool

ns and obnﬁ .E
.Isvoxqqs nljisws srs 19d:
,VGQI

sonlz

bsvsees svsd esrdT .9onsbnsqeb saslqo ul I311: 101 snoxolsn
,ajalnogsjnA alsoDIsM no eonerslnoo 9d: bsbnsjjs seed: has enaelieq we}
,sgeiIoD ruo has djlssH Isnneﬁlo ejujijenl {Bookish ed: yd bsrosnoqe
33d: 33 insunqqs saw 11 .A snuL no onlolbe” lo vmsbsoA an: is bled
ed bluow snoxolsn I510 stoled viseasoen asw vbuje 930m 35d: gnlnssm
sash ed: 35d: enokaeenguz .sonsbnsqsb ensiqo lo jnsmsssrn 9d: at Iuiseu
.szunemerq era AGM as 103 v303oslal3se are noljsothqs 21d: :03
970m

7

weigvﬂlr-‘g'v'w’vu-

way-u—r-y

V

—

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                  <elementText elementTextId="103303">
                    <text>L.=i-r..

;

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a»

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,

“m .‘w,’~augvt.r‘...vswvup--N...h.

ma.vr;\r.:§ll“§llrpVy-1n'wua’l'7‘0

June 29, 1970
Br. Jorge Garzon

83-30 Victor Avenue
New York

Elmhurst,

Dear Mr. Garzon,

I am pleased to accept your invitation to present
of our data on the EEC profile of doxepin. For purposes of
reference, the following are pertinent.

some

I am Professor of Psychiatry, New York Medical College;
and the Director of the Division of Biological Psychiatry of the
Department of Psychiatry. I have been at this college since 1966.
Prior to that, I was the Director of the Missouri Institute of
Psychiatry in St. Louis and Research Professor of Psychiatry at
Washington University (1962—1966); and the Director of the Department
of Experimental Psychiatry at Hillside Hospital in Glen Oaks, Queens
from 1954 to 1962. I graduated the New York University College of
Medicine in 1945 and an certified in Neurology (1952) and in Psychiatry
(1954) by the American Boards.
Thank you for the

invitation to participate.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

gum-mour

,

777,—..."

,

�</text>
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«v-

'm’m'l""

rwr—U‘

June 29, 1970
Miss Irene Jeryn

Hospital for Sick Children
Toronto Canada

Dear ﬂies Jeryn,
Your recent request to the Psychiatric Research
Foundation of Missouri to purchase a copy of PRF 66~1 was referred to

me

for reply.

Unfortunately, the supply of this report is exhausted, and

your order cannot be

filled.

In the evnt the

specific questions,

we

to the address above.

scientist requesting this report has

would be pleased

to anauer these, addressed

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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            <element elementId="50">
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      <elementSet elementSetId="1">
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NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
Mr. 11 B. Schwartz
TO'

Max
FROM:

Fink,

June 29, 1970

DATE

M.D.
SUBJECT

attached

memo

Please request honorarium of $50.00 to be issued to Dr. Sarnoff Mednick,
2 Perry Street, New York, New York 10014.
This should be charged to
Research Training Funds and is for seminar which he presented on
April 14,1969.
Thank you.

mm:

Kﬁ}’:i

2X5

�</text>
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                    <text>“a

—

-

a

”A... m...

,u—W nwl.‘.‘y€'WIV-m—’;r‘-

.gwwqms

”w:

‘

(W's.

r

w

~

a...

N

'

-&lt;

'x'rz- rm...

-.::

.

x

.

awn

~

:

wrv—vw

v... .u.mvasn-.-.

l

raw--

vvv

a

—

up

June 28, 1970
Dr. Russell Taylor, M.D. Ph.D.

Philadelphia General HOSpital
Philadelphia
Dear Russ,

If I understand your question, there is a proposition
before the
to develop a certification in clinical pharmacology
A.M.A.

by the American Board of

Internal Medicine.

For those interested in the clinical pharmacology of
affecting the central nervous system (or other systems
not ordinarily considered part of internal medicine as eye and
skin), an examination as part of the Boards in Internal Medicine
would be unsatisfactory. I believe clinical pharmacology to be a
derivative art, and not limited to internal medicine, being part of
each subspecialty.
compounds

Certification in clinical

pharmacology by each of the
be
but
this would be unwieldy.
considered,
may
would
serve to upgrade the discipline, however, and in Psychiatry
It
the development of an examination in child psychiatry has apparently
done much to improve the training in this specialty. If there
is a need for upgrading and certification, I would tend to favor the
model of child psychiatry, rather than certification in one board
only (e.g. ad internal medicine) or even the development of new

specialty boards

specialty or a conjoint board.

It is

a complex qyestion and

opportunity to expeess these views.

I thank

you for the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>r'

wan——

7.

m

'

.

:4

.mwn-w—ww-onmxmnmmw mum-w W‘x-‘Iv‘r—V'Wﬂurm

»

~~m~

m

"—-

.,

”ﬁr ”wry“. m“. .mwm. V.m._...,,.vw-

v-wmﬁorf‘

June 28, 1970
Miss Bernice RoBerts

Lilly Research Laboratories
Indianapolis. Indiana
Dear Miss Roberta,
Your request to the

Missouri for a copy of

Psychiatric Research Foundation of
sent to me for reply.

PRF 66—1 was

Unfortunately, the supply of this report was exhausted

some months ago.

In the event that the scientist requesting the information
wishes to write regarding the details of that study, we would be pleased
to hear from him at my present location.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>June 28, 1970
Dr. Albert Kurland
Maryland Psychiatric Research Center
Baltimore , Maryland
Dear Al,

It was a pleasure to visit your research center yesterday,
and I was very impressed with the progress that has been made
last visit a

since

my

Clint

Brown.

few

and you have assembled an

I

am

enclosing

years ago.

exciting

"s

“w“...-

that there are

.ﬂ‘m.wﬂ

you and

for

ECT

this instrument for quantitative

-v

reports for

With regard to the PDP~12, I would like to reiterate,
many programs that have to be written in order to use

.r‘r-p'vmn‘ri-A-

WG‘mWaN—umxﬁu?

and

very fine

project, I am sure that we will be
able to assist in the analyses of the EEC data, provided the information
is collected in a form compatible with our equipment. For Clint's
information, we have l/2 inch, Ampex SP 300 7-channel FM equipment.
As soon as I have a change
to review the protocol and obtain a
clearer image of the amount of data to be analyzed, I will be able
to submit a more detailed suggestion.
With regard to the

,,

reprints

some

facilities are

The

group of co-workers.

EEG

analysis. If the various users

ﬁéfiuﬁocéﬁdﬁeﬁiﬁé§ ﬁeeﬂﬁéﬂld be possible to obtain the services of
igédigﬂﬁtbﬁgcﬂdffiifeHﬁfﬁﬁpcﬂoC§H§f§t in the programming. In addition
ﬂo'tﬁd Eaﬁiﬂfﬁants listed in Don Klein's letter, I would be pleased
to have my associates provide you with a bid on the system that may be

useful.

3"”9 383 I630

My

thanks for your kind invitation and

hospitality.

.
.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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              <elementText elementTextId="43773">
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                    <text>,.

ww- .

WWW-”1|.“r:-.--_-n;.T-.--

_~,_3

.

'

"WWW
&gt;

,

~

,

,

»

‘w-w “WWWIWWWIM gym—saw» .mw.~w-»wv-at”- 1,... .M V ,W "wt.

‘,__,_,

“f,

V”

.,

..

,.

.
.7—

,

June 28, 1970
&gt;‘nm’mvvmwv'qlmev-wun

Dear Dick,

-—m’n-w—Mn~w.mqr‘u

«4

r

With reference to the
for membership:

ACNP

request regarding nominations

I would like to nominate two of my associates, whose
work is well known to me, and who will be able to make significant
contributions to the College:

1.:“unwm

Jovan Simeon, M.D.- Assistant Professor at the
New York Medical College. He has been working with me since 1966,
and is now a project leader, working in adolescent and child psychopharmacology.
Ali Keskiner, M.D.— Associate Professor, University
of Missouri, St. Louis. I have known his work since he joined
the Missouri Institute of Psychiatry in 1965. He is an independent

investigator in schizophrenia, with particular interest in rehabilitation

-

..

wrwnr.

as

it

is enhanced by psychoactive drugs.

In addition, there are three young men at this College
independently and should be candidates in the
are
next few years:

who

now working

Richard Abrams, M.D.

Arthur Zaks,

M.D.

Richard Resnick, M.D.

Dr. Keskiner

have already seconded the nomination of
year; and will recommend Dr. Simeon next year, if

I believe that I

this

this is permissible.

Good luck

!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

I

�</text>
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                    <text>« «aw—Wm “‘"1H-3y»

"

‘“

‘

~‘

'“"‘

"*‘V‘rvr-ﬁ~é“r*~"'v--*"’r"

‘&amp;

'W

--u.—.

‘w

&amp;n~‘1-Ir:"'.9¢'~‘-WH-

,

,-&lt;.v—w.‘:r.-m-~«M. EEW'rv—W' u.‘

,7

.
.n
._..r....r....r‘....-,.~-..,..;..-,v..‘..._._.,..(n
.
_

v

..._.

.

~

.,
.

1

«a.H

,
w
hm . w . 'ry4.‘.::,
.rn.‘ -1...“
,

,

June 27, 1970
Dr. Jonathan 0. Cole, M.D.
Boston State Hospital

Boston, Massachusetts
Dear Jon,

It is a pleasure to respond to your questions of the
of
to recognize heroin and to distinguish its
post—addicts
ability
effects from other compounds. Our data may indeed be relevant.
In a variety of studies, we have administered heroin
(15 to 25 mg/icc/Z minutes), saline, cyclazocine (0.2 to 1.0 mg/Z cc/
2 minutes) and naloxone (0.4 to 1.8 mg/Z cc/2 minutes) to post-addicts
(3—20 days after last doses of methadone) and to subjects receiving
chronic oral methadone (100, 150 and 200 mg] oral/day).

addicts, between 20 and 35 years
of age, with histories of opiate use for at least 2 years. Our sample
consists of 35% Puerto Rican and 50% negro. They are voluntary admissions
to Metropolitan Hospital and their cooperation is obtained for these
experiments by indicating that these teats are necessary as prerequisites
to chronic maintenance therapies with cyclarocine or methadone.
The studies have been in progress for 4 years, add in this
time we have examined more than 100 subjects in more than 400 experiments.
The

subjects are

young male

Based on this experience, I believe the following conclusions
are applicable to your questions.
1. Can addicts recognize heroin, given intravenously and

double blind?

Post-addicts have no difficulty in immediately identifying
They make occasional eraors with 15 mg, indicating a
difficulty in positively identifying this quantity. They identify
cyclazocine as a noneopiate substance, and naloxone has always been
called a 'blank'.
25 mg

.
"urn—rmri

«mo-a-

heroin.

..
—,

u:

vl—‘W'I-r-u‘,"

Am

..

-;~,-.

‘.‘;-W'V!

«ﬂy-1.

r-p

.4.

,.

any“...

'Ivnr'i’vw

1

-

Subjects receiving 100-200 mg methadone daily, cannot
identify 25,50, and 75 mg heroin for up to 48 hours; thereafter they
rapidly identify the small doses of heroin, not only by direct heroin

effects, but

hours.

by the

relief of

withdrawal which

is present about

48-60

,
«Yo—am.

an.“

:y:

u--.“

.m

:

�For post-addicts and methadone subjects after 60 hours,
the administration of heroin is accompanied by a sequence of experiences
described in such a ritualistic fashion as to make us believe that the
effects are commonly experienced. The subjects are tense as the injection
is first made, and after 1.0 to 1.5 cc, they relax, smile, and tell us
that this 'is it': they feel warm 'all over'; and within 2-3 minutes,
are comfortable, drowsy, cooperative and tell us that they are 'high'.
u

,umv

—~

—,

sequence

is

no good', and do not become drowsy.

‘Arw¢v.4w1v‘m~4rv—|

r

is

a placebo, nsloxone, or cyclazocine are given, this
not apparent. They remain tense, complain that the 'stuff
When

our

For the patients who have had morphine, they tell us that
does not feel like morphine since they lack the skin tingling

stuff
is characteristic of morphine.

which

I would conclude, that addicts can tell 'good stuff' from
The amount necessary in our subjects is 20-25 mg. (The
clinical effects are accompanied by characteristic EEG changes; and in
the methadone treated subjects, bedore 48 hours, the EEG effects are
indeed absent, as are the behavioral effects).

the effects.

2. Our addicts can discriminate heroin from the substances
above.
They can also tell heroin from alcohol and barbiturates,
indicated
am
if I to believe their reports, but we have never made direct experiments
along these lines.

v‘

r

m'wmm

r
w.

.un'-q-I

u

.

distinguish

I have never tested the ability of our subbects to

among

I
specific
posed them, I
may be useful

have

While I do not
data to answer the questions posed in the way you
will send the reprints and preprints available, and these

I‘M/r.

If

mr'

mumpwr

-

opiates.

trust these responses are helpful.

in supporting your evidence.

it

your presentation.

is of

any help,

we

can be

available to support

/:u4-w~

A"..W5w31r.lp'-

best regards, and I do appreciate the Opportunity to
answer these interesting questions.
My

«-

w

xv

,
‘mm

Sincerely yours,

v”:

'A

vvw—w

JD'WﬂI'W

Fink, M.D.
Professor of Psychiatry

Max

yam-v

ov-nrw'wnrvv

.
nun-s.

n

-..
‘
~

”army-n:

mf/

�r Zwm'jiﬁhzx'n» ”w“

.

.p—

--. -mpmmu

,

as.

.,_.,.

June 24, 1970
Dear Costas,

Finally, I have very good news ! During the past
month, the grants management staff of the N.I. M. B. have met
with me on three occasions; each time we resolved another problem
and today, they signed a contract allowing us to undertake the
study we discussed more than 15 months ago. The problem of
cannabis is still acute, and despite many new studies, there is

still

confusioin about the possibility of chronic effects.

The contract permits the International Association
subcontract
with
scientists in Athens to study the problem
to
of the chronic effects on brain function and behavior of cannabis.
The goal is to study as many men as may be found who have been
taking cannabis regularly for extended periods; to measure the
degree to which brain dysfunction may have occurred; to undertake
acute experiemnts, in which the EEG, memory and perceptual changes
of cannabis smoking may have an effect and to record the changes,
with analyses completed in Athens or in New York. We are also hoping
to have supplies of cannabis from the men themselves, with portions
smoked and others analyzed in your laboratory. In addition, we
are permitted to ask that some THC be extracted and tested in
these clinical trials.

I do not know how much can be done. The original
been
has
accepted, with few modifications. It seems
protocol
best that I arrange to meet with you during my forthcoming trip
to Europa, and that a more definitive protocol be worked out;

particularly one in
proper

staff

which the work

is detailed

so

that the

can be recruited and a work schedule prepared.

Dr. Freedman will also be in Europe this August
and I hope that he will have an opportunity to meet with you
and discuss his goals for this project. Unfortunately, I do
not think I will be in Athens at the time he may be available.
As my

plans

now

stand, I will attend the Turkish
in Athens from

C.N. P. meetings from August 17 to 21, and can be
the afternoon of August 21 for the next few days.

If that is

not satisfactory, I could take my family to Israel for
and arrive in Athens August 25-27.

some days

We

look forward to working with you, Dr. Stefania

My

best personal regards.

respective associates. I hope that we will be able
contribution to the definition of the problem of
the effects of cannabis.

and your

to make a

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>9 upyal-rl'xn

-

,n,.,,.c‘.,(“v.19

ﬁrm“,

LN}.

“J’mefw—zﬂwy..ww :i-w

I

_

A ‘rj‘ru'

'-

-. :7"

,1...

»

.

x

,

~5w’e‘w "fr: .“rr

~v,«

'rgu-W,"

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v'w

-

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-

--

.-: tv

‘14...

23-

~-' v

June 23, 1970
Dr. Sudheer Gogte
3/37 All India: Institute
of Medical Sciences
New Delhi 16, India:
Dear Dr. Gogte:

Separately I

am

sending the reprints you requested.

Our college has a formal course in pharmacology leading
Ph.D. degree. It is not a clinical program however, In
this country, the clinical programs that are well known are at
Vanderbilt University (Dean, School of Medicine, Nashville,
Tennessee) and the University of Michigan (Dean, University of
Michigan School of Medicine, Ann Arbor, Michigan).

to a

you the

I have asked our Director of Residence Training

applications requestdd.

to eend

As to the cyclazocine report, we selected imipramine
failures since: (1) cyclazocine was an experimental treatment;
(2) the only justification for its ethical application lies in

trials

in those

We

who

fail other treatments.

have discontinued these studies because cyclazocine

is no longer available for experimental trial in depression.
It was concluded, that despite its antidepressant activity,
cyclazocine was associated with sufficient secondary effects

as to preclude its usefulness in mass trials. We are interested
in homologs of cyclazocine. ﬂow, and these should be brought
to clinical trial in the next few years.
Thank you

for your careful inquiry.
Sincerely yours ,
Max

Fink, M.D.

Professor of Psychiatry

Psinkk

�</text>
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                  <elementText elementTextId="105898">
                    <text>“1,”,7,”

.__,

,.. .._.,..r

.

.,

"um.

..

7.,w‘Jg 7W a V...”

r M-

3.71.1.1v-71 sung-n.1,

1

.1

1.1,.

inquu‘wﬁ‘rw,, ..

1,,.-cv:-:.,,r

1h

.wwxum~r:mwrr ‘gt‘cwmuew‘kwrﬂ‘ W"

w‘uué

vmwa-w

June 23, 1970
Dr. G. F. Blane

Reckitt &amp; Colman
Hull, England
Dear Dr. Blane,

?

?

and

I look forward to meeting you on July 15;
will arrange to meet either in the city or at Kennedy

airport, whichever is
Hay

L

g

most convenient

for you.

I suggest you call me on July
? I can be reached:

to confirm a time and place
0700—0830

13

1900-

516 466 5444

(home)

1000-1730

212 369 8488

(office)

I look forward to your

visit.

Sincerely yours,
Max

mf/

Fink,

M.D.

or

14

-,.~,..

_

“u. .~,-~

,,.

-~ww-~

&gt;,ay-w-

r‘w‘-'.n&lt;-r'M-Vnm

.1.

r

IPZMF" 1”

�</text>
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                    <text>June 23, 1970
_

”Ml’v:

8*-1‘1'

5-2

4

Dr. Lois Chatham

National Institute of Mental Health

5454 Wisconsin Avenue
Chevy Chase, Maryland

20015

”was"

um.

Dear Dr. Chatham:

4—.

mum-mu:

nun

:MW

I am pleased to enclose a copy of the program of the
Special meeting on narcotic antagonists and a summary which
we have just prepared for Science,
We

have just expanded our cyclazocine program in a

full clinical trial, hoping to treat 100 addicts in the next
twelve months. While this number may not be large, it does

of our ongoing program from a research
We will be seeking a way of
insuring an independent clinical evaluation, and I will bring
the NARA recording to the attention of Dr. Freedman.
represent

an expansion

model to a.demonstration one.

My

thanks for your patient and thorough explanation

of PL91~211.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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                    <text>June 17, 1970

Editor

Drug Research Reports

Washington, D.C.
Dear

Sir,

For many years we have supported investigations
in the role of narcotic antagonists in the treatment of opiate
dependence. A meeting on this subject, attended by faculty from
various medical centers and industry, was held at the Academy
of Medicine on June 4. It was the concensua of the workers, that
the results of the early studies were much better than the press
had reflected, and that further study was ind eed warranted.
The editorial in Science highlights the lack.of general
information on the role of the antagonists or the results of the
early studies. Perhaps, a small summary in your newsletter would

helpful in bringing this information to the attention of other
agencies of industry and government that may have antagonists that
warrant testing, or who face the problem in the community and
wish to he informed as to all the available methods of treatment and
research.
be

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>mm“

-w—v,a..

«yr.

.
,2

....

1..

g.

y‘v-cmwt‘lmlﬂv-Anw

w:-

vva.ﬂw‘nmggr

'

‘

.

v

Z‘IIW‘M’W—aw,.W

June 17, 1970
'

hr. Fred Brunet
135

475 Northern Blvd.

Great Heck,

New

York

Sear ﬁr. Brunet:
want to thank you for your prompt
maintenance on our IBM 1800 System.

I

attention to our needs

I was as startled as
been made since
had
cells
you that no preventive maintenance
issued
October 1969 and that none of the engineering changes
date.
same
the
by IBM Had been installed since

for

In our meeting with

Mr. Bull on

6/16/70,

we

agreed that a

would be made on 6/22, and bi~weekly thereafter until
were indicated.
we were assured that less frequent calls
responsibility.
PM

call

Hrs. Traynor of

my

staff

was

assigned the liaison

ﬁr. Bull indicated that there were 15 hours (approximately)
parts and as soon
of EC required. He has requested the necessary
to be installed
these
for
as these are assembled he will arrange be done no later than 6
on week—ends. I assume that
weeks hence, about July 30.

this will

the frequent pattern
also shared our anxieties regarding
we
were assured that
and
of downrtime after EC's are installed,
plus croesnchecking
diagnostic
all EC's would be followed by full
We

against our running programs.
in this purchase and
I am most grateful for your cooperationdetails
of this significant
in assisting us in the many administrative
re-arrangement of our relationship.
Sincerely yours,
Max

Fink ,

3‘10 D u

Professor of Psychiatry

HF:kt

cc:

2%?)

'5:

Dr. D.

miner
M.

Shapiro

.w.w("vl'

�</text>
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                    <text>June 17, 1970
Dr. Harold Meiselas

New

York

State Narcotic

Addiction Control Commission

1855 Broadway

New

York, New York 10025

Dear Harold,

regretted your prior committments
that precluded your attending the meeting on Opiate antagonists.
We have been encouraged by the latest editorial by
Philip Abelson
in Science to summarize the proceedings and submit these to his
journal for publication. A cepy is enclosed for your information.
Beth Al Freedman and I

Perhaps

we may

meet soon to review

this data.

Sincerely yours,
Fink, MD.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>Wm—vwv

,

-

'~-

_.

June 17, 1970

Editor

Drug Research Reports
Washington, D.C.

Dear

Str,

For many years we have supported investigations
in the role of narcotic antagonists in the treatment of opiate
dependence. A meeting on this subject, attended by faculty from
various medical centers and industry, was held at the Academy
of Medicine on June 4. It was the concensua of the workers, that
the results of the early studies were much better than the press
had reflected, and that further study was ind eed warranted.
The editorial in Science highlights the lack of general
on the role of the antagonists or the results of the
studies. Perhaps, a small summary in your newsletter would

information

early
helpful in bringing this information to the attention of other
agencies of industry and government that may have antagonists that
warrant testing, or who face the problem in the community and
wish to be informed as to all the available methods of treatment and
be

research.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>Irv-w" _.... . urnv'vlwmnrﬁ‘v'vm rmt‘ arm—a

e n’

}

June 15, 1970
H. Abelson
Science
Editor,
1515 Massachusetts Ave.,
Washington, D.C. 00005

Dr.

Philip

N.W.

Dear Dr. Abelson:
”Death from Heroin,” in the June 12 issue
of Science, highlighted an important medical and sociological
problem. The conclugion that two methods of treatment, methadone
and emotional support, seemed promising, omitted what may be
another exciting and potentially significant advance in opiate
Your

editorial,

dependence hiatOry

- that of the use of Opiate antagonists.

Coincidentally, the same crisis in heroin deaths spurred
antagonist data.
early May to call a meeting to review the New
York Academy
The meeting was hastily convened June 4, at the
of Medicine, co-sponsored by the National Institute of mental
ﬂealth. We regret we did not know of your interest in this
issue, for we would have gladly invited an observer.

us in

.

have prepared a summary of the meeting for your considera—
tion for publication in Science. The list of participants includes
the American scientists actively involved in clinical trials, as
well as pharmacologiata and chemists with interests in opiate
attended
antagonists. Industrial and governmental representatives
with
an
and hopefully, returned to their laboratories and offices
appreciation of this approach to opiate dependence.
We

Publication of this meeting summary in Science may serve to
inform others, unable to attend, of this progress, and may stimulate
additional research endeavors.
Sincerely yours,
WWWT.M

Max Fink, M.D.
Professor of Psychiatry

1

.v-‘mw

Hszp
811C .
NW“.

,

�</text>
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                    <text>E

E

.3

K

5

l

I

,..,,,,....,

..

.77

h.‘

1

.

a,”

,

“was”?

...,

w

,.

,,.,....

,.,,...,,_...,..r.,.,,

,1 ..

”r“.

,.

7, ~r-.‘-"‘~r

wwnm.‘

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.

.

.3,

.s

.

.

,

.

m

.-

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.

7-

.K,

"V&lt;V"i-"W—Vw

June l5, i970
Dr. Wilma Harrison

Geigy Pharmaceuticals
Ardsiey, New York
Dear Wilma,

Following our discussion of June i0, i am pleased to include
reports of our studies of GP 4l299. The clinical report,
dated June i, l970 (iV: 6-l0-70) summarizes the data to May l, I970
with supplements to June i. As we discussed, these clinical trials
will continue to the limit of the available supply of GP 4l299.
You indicated that IOOO additional capsules will be shipped, and we
two interim

estimate this to be sufficient to add

3

additional subjects.

will complete these trials during the next 8-l0 weeks and
submit, in September, a final report with the case records, Gelgy
report forms and laboratory summaries.
We

report (ll: 6-i5-70) describing
4i299. it is clear that the EEG profile,
at single 75 mg doses, ls readily distinguished from placebo and most
resembles the drug, doxepin. For a definitive bio-classification
study, i would recommend an oral EEG comparison against doxepln,
chlordlazepoxide, imlpramine and placebo.
am

i

the

EEG

also enclosing

classification of

an interim
GP

clinical trials in progress, we would also suggest
clinical trial of GP 4l299. i am pleased with the
present pilot data which indicates that 225~300 mg/day is well
tolerated, clinically effective and safe in our laboratory tests; and
that the target symptom is overt anxiety. From the EEG profile, i
would suggest that measures of depressive mood be added and patients
with manifest depression be included in the trial. A protocol for such
a clinical study will be prepared in September.
Based on the
a more definitive

i

trust these data are useful,

Your comments on

grateful for your cOOperation.'
these interim reports will be welcome.
and

i

am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkf

enc.

interim reports

#2
#3

(iv: 6-i0~70iand

(ii:

6~l5-70)

�</text>
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                    <text>.,.._....—11.,.‘

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June l5, i970

Irv-""31-

"zrmw

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7......

Dr. Richard Philiipson
Hafionai lns+i+u+e of Menfal Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 200l5
Dear Dr.

wmmoruVNow—n-

Phlllipson:

Both Dr. Al Freedman and

i

regreffed your prior commiffmenfs
on oplafe anfagonisfs.

that precluded your offending fhe meeting

have been encouraged by lhe lafes? ediforlai by Philip Abelson
in Science to summarize fhe proceedings and submi? These To his
Journal for publicafion. A copy is enclosed for your informafion.

We

“w

Perhaps

we may

meal soon

to review fhis dafa.
Sincerely yours,

rwmeW-m

1‘

Max

7..

Fink, M.D.

Professor of Psychlafry

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                    <text>June l5, l970
Dr. Henry Brill

Pilgrim Stale Hospital

w. Brenlwood, New York

Deer Henry,
We missed you a? The meeling on
enfegonlsfs. The dafa was
encouraging, and Three issues were feel of furfher sfudy:
l) A collaborative, mulfi*hosplfai evaluaflon
of cyciazoclne (add, if supplies are available,
of naloxone).

2)

Developmenf of long~acfing

anfagonltf, with

durafion measured in months.

'9'“

’l

3)

17w»

'I-r‘

Duran“!

Preclinical pharmacology of new antagonists
now available a? Endo, Reckiff &amp; Colman
(represenfed by Lederle in U.S.), and 3+ fhe

University of Rochester.
.q'u't'!"‘1".r“f"

A

"an:

u

summary

Science.
gamma-ma.

is enclosed, as

i

senf if to Philip Abelson of

:'-‘Vw,

Your encouragemen? has been most supporflve, and

may

”will conflnue.
My

«Wuv-Wwwawnrv'v;

beef regards.

Sincerely yours,

.7»;

‘..mwf§33IZ-‘9'F‘P§§

Fink, M.D.
Professor of Psychiefry

Max
FW‘x-ir'l’h’

wr

wars

inmate's“

m

r

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nm‘nrxmr

M‘srm'ﬂm‘rewm

Inhk‘i’

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you

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                    <text>.-v.w.r~~—.~..m.

xv-

x.----—.-»

r“

r—v

V0.

nM. v:“Hm,” w. .., uv“ u

.

V

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_,

v

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v.1

pa:
.n... vv-gzv—uu'h'vx-vww'
_

..

.w-w—w-q-waw-s-u

'niW-z-I».v
‘E'w,r'-.-n“~"NM‘KNV‘TJJW'S'W'

June 9, l970
Mr.

Polar

Hammond

Execuflve Director
Naflonal Coordinafing Council

Sulfa 2l2

i2il Connecflcuf Ave.,

Washingfon, D.C. 20030

N.

Dear Mr. Hammond:

in

Enclosed is a shorl biographical skefch for your use
for the Naflonai Coordinailng Council meefing in July.

PR

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlalry
MF:kp

one o

.u

,-

.‘r:«-‘4

u...

-ur V,,_‘,.....‘

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�</text>
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715')

«I'RI-Z

n-

“no-v.7...

‘u'wv-m

«-

grrwyvvjw

Maw-r

wan-“W:

June 9, i970

'u-wuv‘wr

una-

'¥;\

WWI-759'

.

.

Dr. John I. Nurnberger
Deparfmenf of Psychiafry
lndiana University Medical Cenfer
iiOD W. Michigan 3?.

Indianapolis 7, indiana

Dear John,

if

was kind of you To recommend Dr. Fred Johnson +0 us.
spoke +0 you in San Francisco if was in response +0
fhe quesfion of Trainees from overseas. We have posifions
open for clinical psychiafrlsfs and research fralnees in
neurophysiology and biological psychiafry.

When

i

i
regref fhal we do nof have a posifion for Dr. Johnson,
buf Thank you for your recommendafion.

Sincerely yours,

A

,

‘Iv-‘rv'vr

Max

Fink,

M.D.

Professor of Psychiafry
MF:k+
.

,

«Irv.

7Iﬂ5i1‘ﬂ'alll‘w‘V

yam-V

�</text>
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”my

”—1.4.

.-.&lt;

{.‘A

-.

rug-’1'"

June 9, i970
Dr. Fred H. Johnson
l58 N. Humphrey Ave.
Oak Park, Illinois 60302
Dear Dr. Johnson:

regref
curriculum vlfee.
neuroanafomy.
in
or
neurology
do nof have a posiflon open

IT was kind of you +0 send your

The? we

When

was

in

I

discussed

for psychiefrisfs

I

opportunify wlfh Dr. Nurnberger, if
in Training who were parficularly inferesfed

The

clinical psychiafry or oplafe dependence.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychia+ry
Mszf

�</text>
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                    <text>N

mm,(

v
anvnv _,;rv,

., mun—.3...

w—

W-

nw w:.- it r~ “— n.

7

.1”

.— wrru
.

«v.

W —n-.Wm”I“., --v. 1.: M
.\

w

-

.7,

W

‘n

June
Dr.

Everett

H.

-r' ns'v'
‘

’4

v

W" r7
»

1....
. vane Wm:-a'pw.w(—»VVINuna- M1." «‘1va mum-u» in? :' 7W!“ {-1. :~»rc;z-.:-vzv
_,

,

-

, 1970

Ellinwood, Jr.

Department of Psychiatry
Duke University Medical Center
Dlmham, North Carolina 27706
Dear Everett:

I found the session on antagonists so exhausting that
I was unable to attend your session. I am sure you will mange
for its publication, and I look forward to this (albeit second

best)
v

:11”:

was

of attending.

131m again for the invitation, and I look forward to
seeing you in Prague.

,.

Sincerely yours ,

r)

1,...”

rug“...

pﬁ-

.

_&lt;

“n”,

:
.

Max

V

.
".7.

Am

-p

we

”Www—r-n—mm

W’k

nr-IW'

um

,

Fink , M.D.

Professor of Psychiatry

’3‘...“

mf:kp

�</text>
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                    <text>.

wu'ar'w-nmw.

ynvm :l-g-«Q‘Tiiw-w'i‘p‘i‘

mum.-. ..,,‘.,n.w,.-n-

.mvw.

umpw

murmw

A

.,

A.“

._

,y—rrw-v

June
Mr.

Jared

R.

Coordinator

14

, 1970

Tinklenberg

Psychiatric Residency Program
mpartmnt of Psychiatry
Stanford University Medical Center
Stanford, California 9u305
Dear Mr. Tirﬂ&lt;lenberg:
and even
I very mch enjoyed our impromptu discussion
The
problem of
most
which
interesting.
are
more , the reprints
our
to
related
is
possibly
drug altered inmediate mum

studies of

menm‘y changes

in

ECI‘ ,

and the

data was even

more

interesting to us in this regard.
Thank you for the kindness in sending these reports and
in
my best wishes that the studies continue as successfully
the future .

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry
Max

Mfzkp
,

1

3

1

r
;

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1

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                    <text>l
wwww-rm

mmr—w—vv—

-

Eww'wlav‘m"

w-"qur'nylvyﬂw'nlewvrvrtvn'mwttAwww—wa'

Juno 9, l970
Dr. John I. Nurnberger
Deparfmeni of Psychiatry

lndiana Universify Medical Confer
liOO w. Michigan Sf.
indianapolis 7, lndiana

&gt;wr1r

Dear John,

r-«mw»

—"r

-m

W...

"yr-WWW

,

if

was kind of you to recommend Dr. Fred Johnson +0 us.
spoke +0 you in San Francisco if was in response +0
fho question of frainees from overseas. We have posifions
open for clinical psychiafrisfs and research Trainees in
neurophysiology and biological psychiafry.

When

i

rum-I‘llw-ﬁ‘v

i
_

regrof fhaf

bu? ihank you

we do no? have a position for
for your recommendation.

Dr. Johnson,

Sincerely yours,
mum-&lt;4

Max

Fink,

M.D.

Profossor of Psychiafry
MF : k'i‘

�</text>
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                    <text>-“,..__..,,Y.-

WV»-

,

...‘

._m...

‘,,_.......V.

WWW“?

W. mpwqup F.“

,,

“a...” .

"Hm-,MJ ..

H...rn.,.._.,...-v_...m

nu...-

,

r»

‘.-—w~ie~,-.mv

x- ...~~

-

v-

A

7w."

m.

V.”

June 9, 1970

(.7

1—.

.

"If-wl‘tﬂ)’

Qw'w-U-vmrvw

)r

Dr. ﬂerle L. Gibson, Director
Division of Neuropharmecologicnl Drugs

Office of New Drugs
Bureau of Drugs
Food and Drug Administration
Rockville, Maryland 20852
Dear Merle,

RE:

IND 6825
Methadone

With reference to your letter of May 14, 1970, enclosed
the
additional information requested, i.e., my curriculum
is
vitae and the present protocols. I have requested a letter
from Eli Lilly regarding reference to their submissions for
formulation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

.

v“.

—.

v.

»

�</text>
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                    <text>June 9, 1970
Dr. Ivan Bennett

Eli Lilly Research Laboratories
Indianapolis, Indiana 46206
Dear Ivan,

Enclosed is a copy of a letter from the FDA requesting
since I have
information as to the formulation of methadone, studies
in
just filed an IND to permit us to continue our
opiate dependence.

written authorization to refer to the
manufacturer's formulation date for methadone as requested
in their letter.
May

I request a

Many

thanks.
Sincerely yours,
Fink, Md).
Professor of Psychiatry

Max

-

MF:kt

enc .

�</text>
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June 9, l970

Polar

Mr.

Hammond

Execufive Dlrocfor
Nalional Coordinating Councll
Suite 2i2
l2ii Connecflcuf Ave., N.
Washingfon, D.C. 20030
Dear Mr. Hammond:

in

PR

Enclosed is a shorl biographical skeich for your use
for +ho Nafionai Coordinating Council meeflng in July.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlairy
Mszp
60C.

�</text>
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                    <text>.

rah-rm TH'P-v—V-Ih".--

nun-r

I
‘:

ww‘

u-nw-

'

L

“CW“.

,,,.

.7.

.

‘va

June 9. l970

)1

'x-Mw,

CepT. RoberT Levine
228 Texas Drive
Dyess AFB, Texas 79607
Dear Bob,
lT was a pleasure seeing you in California. l didn'T have
a chance To fly back wiTh Hy Denber so we dldn'T sTop aT Hobbs.

ll

have had an opporTuany To discuss The possibiliTies
of your reTurnlng To New York nexT July and There are Two opporTuanies
which presenT Themselves imediaTely. As you know, The DeparTmenT
is expanding noT only inTo The new menTal healTh cenTer (hopefully
by March) buT we have esTablished a formal relaTionship wlTh
Grasslands and The MonTrose VA. in adlelon, we are sTili negoTiaTlng
e reiaTionshlp wiTh Kirby HospiTal (l/3 ManhaTTan STaTe HosplTal).
This lasT relaTlonship is sTill in The discussion sTage elThough
each monTh I hear opTlmlsTic noises from Al Freedman.
1

and

l

The relaTionship wlTh The MonTrose VA is esTablished and Al
Freedman is Chairman of The Dean's CemmiTTee. They have a few
Thousand paTienTs, plenTy of laboraTory space and a clinical

direcTor
school.

is anxious To accommodaTe research as well as The
have discussed wiTh him The possibiliTy of having

who
i

Two members

of our sTaff appoinTed as clinical invesTigaTors.

believe ThaT These poslTlons can be funded by The VA, and
bring wiTh Them supporTing funds for research, as well as a
research sTaTus which would be mosT producTive for you and Mickey
To conTlnue your sTudles excepT for The obvious handicap of
i

having a small percenTage of female peTienTs.
has much To commend lT for your work.
i

VA

am

enclosing copies of

The

The

VA

populaTion

applicaTlon ouTline for

The

posiTlon as well as a blank i0~2850.

for your reTurn

York I Think you
should apply for This posiTion by compieTinq The form and sending
me a one page sTeTemenT of your fuTure plans and ambiTions and
a proposed research plan (6.09~b~6,7).
3A5

one underpinning

To New

pun-r

�Eyre—merrnw

s,

.

i.

.,

www-

.

WF“ “sun-7w

...._...

,

-~

'--10'

vw~_m_v—.w——

I

Dr. R. Levine

June 9, I970

~2—

in +he evenl Thaf we are successful, your appoinfmenf fo
fhe Deparfmenf of Psychiafry will be ihe principal appoinfmenf.

This appoinfmeni will nof preclude your parficipafion ln sfudles
a? olher
i

affillafed insfliufions.

i would like To recommend lwo of you for These posifions and
have asked Dick and Mickey To fill ouf similar applicaflons if

They wish.
My

besi regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp+
673C.

urn-«w «w»

�</text>
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                    <text>«ihwwt

now-w

‘-

:

'

..

'

”run—1d.”

V

1mm A-uwr-W'I'Wmﬁmw'wh «yr: WWI-F‘anw’p Hurray. ww‘luc-lnhxy,'&lt; 415‘:' -:

-.

v
A

upmrmq.

.n

-;

June 9, l970
Dr. Michael A. Taylor
9309 Murillo Ave.
Oakland, California 94605
Dear Mickey,

it

was a

pleasure to meet

your psyche in such good shape.

you in

California

and

to find

have had an opportunity to discuss the possibilities
of your returning to New York next July and there are two opportunities
which present themselves immediately. 3A5 you know, the Department
ls expanding not only into the new mental health center (hopefully
by March) but we have established a formal relationship with
Grasslands and the Montrose VA. in addition, we are still negotiating
a relationship with Kirby Hospital (i/3 Manhattan State Hospital).
This last relationship is still in the discussion stage although
each month I hear optimistic noises from Al Freedman.
and

Al

I

relationship with the Hontrose

The

VA

is established and

A

Freedman is Chairman of the Dean's Committee. They have a few
thousand patients, plenty of laboratory space and a clinical
director who is anxious to accommodate research as well as the
school. i have discussed with him the possibility of having
two members of our staff appointed as clinical investigators.

believe that these positions can be funded by the VA, and
bring with them supporting funds for research, as well as a
research status which would be most productive for you and Sob
to continue your studies except for the obvious handicap of
having a small percentage of female patients. The VA population
i

has much to

it for

your work.

enclosing copies of the application outline for the
position as well as a blank l0~2850.
i

VA

command

am

York i think you
should apply for this position by completing the form and sending
me a one page statement of your future plans and ambitions and
F5

one underpinning for your return to

a proposed

research plan (6.09~b«6,7).

New

w

�June 9, i970

-2-

Dr. Taylor

in The even? fhai we are successful, your appoinfmenf To
The Deparfmenf of Psychlafry will be fhe principal appoinfmenf.
This appoinfmenf will no? preclude your participalion in sfudies

a? ofher

affiliafed insfifufions.

would like +0 recommend Two of you for fhese poslfions and
have asked Dick and Bob To fill ou+ similar applicaflons if
i

I

lhey wish.

saw your leffer in The Brlflsh Journal of Psychiafry and
wide awake desplfe The sunshine of California.
see The? you are
I
owe you a dinner and frusf i can deliver The nexf Time we
i

slili

meel.

slill

My

beef regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

MF:kpf

enc.

�</text>
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                    <text>mar.

w»

..
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v
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'umw'“:v1r-

”Vt-0

vux'l-r-mz

-vn.-v-\.r-.

,1

”mu

A

w:

June 9, I970
Dr. Fred H. Johnson
I58 N. Humphrey Ave.
Oak Park, IIIInoIs 60302
Dear Dr. Johnson:

II was kInd of you To send your currIculum vITae. I regref
Thaf we do no? have a posIIIon open In neurology or neuroanafomy.
When

was

In

I

discussed

The opporfunIfy wITh Dr. Nurnberger, IT

for psychlafrIsIs In Tralnlng who were parfIcuIarIy Inferesfed
cIInIcaI psychlafry or opIaTe dependence.

SIncerer yours,
Max

FInk,

M.D.

Professor of Psychlafry
Mszf

�</text>
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                    <text>1—,“...

.
,‘

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as.“

W T... “a

.

awn”

germ

,xr—

—

w ...... g

”r "was.-.“ we“ ”v‘va‘wvr'. ”v

June 8, l970
Dr. Avram Goldsfein

Sfanford University School of Medicine
Stanford, California 94305
Dear Dr. Goldsfeln,
Thank you for The

my

invifafion

To

parflcipafe

pleased
membership fee, payable fo Sfanford Unlversify.

NARCOTIC RESEARCH

INFORMATION EXCHANGE,

and

I

am

in The
+0 submif

will send

As

soon as we have useful

My

+hanks for underfaking +hls imporfanl mlsslon.

manuscripts for disfribufion.

reporfs,

I

you

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry

Address of record:
Max

Fink,

M.D.

Deparfmenf of Psychiafry
New York Medical College
5 Easf l02 Sfreef
New York Cify i0029

rr',

we;

�</text>
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              <elementText elementTextId="44033">
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                    <text>June 7, 1970
Dr. Milos Vojtechovsky

General Secretary, CINP, 1970
Sokolska 31
Prague, Czechoslovakia
Dear Miles,
In making my plans for the visit to Prague, I find that
I have not received a congirmation of my reservation request for
accommodations. I have received your receipt for registration.

Since making my reservation, I have decided to take
wife and two daughters to Prague.
I

my

writing to ahk your help in rearranging my accommodations
bath, for arrival in Prague August 11 and leaving
Prague August 15. would it be possible to ask your secretary to arrange
accommodations for my family?
Would it also be possible to send 3
additional visa forms, for my wife (Martha Fink) and daughters,

now

for

Rachel

2

D.

am

rooms with

(age 14) and Linda 8. (age 12)
Many
My

?

thanks for your help.

best regards.
Sincerely yours,

mf/

Professor of Psychiatry

�</text>
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                    <text>June '4, 1970
Dr. Everett H. Ellinwood, Jr.
Department of Psychiatry
Me University Medical Center
Durban, Elorth Carolina 27706
Dear Everett:

I found the session on mtagonists so exhausting that
to attend your session. I am sure you will armamge
for its publication, and I look forward to this (albeit second

I

was unable

best)

was

of attending.

Thanks again for the
seeing you in Prague.

invitatim,

and

I look forward to

Sincerely yours ,
Fink, MD.
Professor of Psychiatry

Max

mfzkp

�</text>
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                    <text>-—

nﬁ‘

.

'

"walniwimmwrvmamwmw,Mmm‘n'.

,

June 2, 1970
P. Kielholz
Psychiatrische Universitatsklinik Basel

Prof..Dr.
-

switserland

nWJ-wmlv-V'

Dear Dr. Kielholz,
v‘rlrmw.V'-Mlﬂnlww"rl“uqx—.

Thank you for your letter 01‘2“le 28. I am sorry that
have invited Dr. Ladewig
you misunderstood the program outline.
to present during the symposium, on the topic of “Amphetamine
and Hallucinogen Dependence in Europe", as a joint presentation
with Dr. Battegay. I wrote to him on May 25, extending the formal
invitation of the Program Committee chairman, Dr. Vinar. By now,
he should have received the invitation.

I

xm'm'm

um

.

Wynn-r.

um

n
«Ir-v

vmmm:

to Dr. Vinar indicating your acceptance
I will write summarize
the symposium and co—symposium
to
the
responsibility
of
the
session.
Plenary
at
with you.

I

look forward to seeing you in Prague and working

Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry
"#7

.

�</text>
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                    <text>1——

-w'r-v.rr—

inw'H'u'Imrs-x'

WWW»

1

"rm-w

r&gt;’V£'WD‘I“-W«-R\ﬁ\‘wwuv,W.nn&gt;"vw-1m¢'-‘W"w1u&lt;":wmun"...

a ”Mg.” 7“,...

«

1....

zv—unchv '(‘VI"-u'«.v 1;».qugrmvlw—mvuvhui‘vﬁm

yr ,4”.

June 2,

~...~

n .7.v.‘.--, m." ' wl‘-».

.

.

‘

a,“

..

,7

1.970

Dr. Oldrich Vinar

Psychiatric Research Institute
Prague, Czechos Zovakia
Dear Oldrioh,
Zine to let you know that Prof. K119131013,
the co-chaiman of the symposium on amphetwnines, has agreed to
the proceedings of the synmoaizm and oo-symposium for

Just a

smize
the final Plenary Session.
My

best regards .
Sincere Zy yours,
3;,“ Fink,

4”,. Do

.,_

..

..

.

..

Wm

..

.

.....

V

.

1.

�</text>
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WWW‘WWTF'

_

Juan

..

at .nm .r-I-uw

T—

June 1, 1970
Dear

Jiri,

returned.

Enclosed

From Vbita,

letter will reach

is a letter I sent

you.

I

some weeks ago, which was

this address and

have obtained

I trust

this

intthe laboratory is progressing very well, and
for many studies we are now in the data analysis phase of our program.
Vbita has reviewed the EEG data of the ECT dstudy, and we have asked
that the records be analyzed by computer to give us better estimates
of the delta activity and the difference between the two sides of
The work

the head.

to complete the methadone data
I have also asked voita should
have computer analysis.
he
and
has suggested that this too
him
be done, and if'we
work
should
asked
that
to outline the
I have
( and I am sure we can) the records will be analyzed this
can do
summer.

it

I

have organized a special meeting of
specialists in opiate antagonists on TEursday. we hope to stimulate
more interest in a long acting antagonist. Al has received a special
contract to develop such a compound and we hope to stimulate some
Al Freedhan and

company

to carry out the chemistry studies.

Kathy has married, and will continue to work as long as
she is able. Stanley and Vbita have developed a good program for
the analysis of heroin effects and I have sent their project to NIMH
for support. we have sufficient funds to begin the study on our own
this fall and I propose to do so, if’only to get a head start on the

project.

lj’all

goes well,

with me to Prague for the
(the Turkish CINP) meeting.

in Europe, for
My

all

I plan

my children and Martha
and
to Istanbul for their
this August,
be
able
we
will
to meet somewhere
Perﬁaps
would be pleased, as would I.

CINP

my

girls

to take

best regards to Marcia.
As

4,,

ever,

�</text>
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.uwun-grp".

June 2, 1970
Dr. Henry Adams

university of Georgia
Athens, Georgia
Dear

D .

Adams,

my associates and I have read your recent report, ”Electroconvulsive Shock, Brain Acetyloholinesteraee Activity and Memory" with
considerable interest. we would like to become acquainted with any
subaequent studies from your laboratory.

are aware, Ulett and his co-workers were unable to
even with higher dosages of'atropine (oft
Johnoon et al., Arch gen Psychiat., 2:324—336, 1960). In reviewing their
experiences, and our own with various anticholinergic drugs, we became
concerned that studies (particularly in man) that dependeddbn the
anticholinergic effects in the central nervous system were often
unsuccessful because the peripheral effects of'atropine exceed the
central effects, especially at low dosages. While the same is less
true for scopolamine, this compound also has extensive peripheral effects.
we tested a variety of active anticholinergic drugs and reported that
benactyzine, Ditran and diethazine seemed to elicit a higher degree of
central activity in proportion to their peripheral effects.(cj2 EEG clin.
As you

replicate their findings,

Neurophysiol. ,

12.- 359—369,

1960) .

time ago, I reviewed the available data on central
and
anticholinergic
cholinergic activity and the convulsive therapy
and
am
I taking the liberty of’enclosing a reprint that may
process,
Some

be

of interest.

Again, our congratulations on a nice piece cf’work.

Sincerely yours,

m Fink,

M. D.

Professor of’Psychiatry
mf/

�</text>
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                    <text>mew—'4‘

"’Ir‘aﬂe‘vwr-«n‘w,"we...

G -‘-4- «mw... W.

,

.7.

————......

m

ww—

7

V

“ﬁrm

«mam-Y

,

in“...

June 1, 1970
Dr. Chris Zarafonetia, M.D.
Univ. Michigan Medical Center

Department of Postgraduate Medicine
Arbor, Michigan 48104

Ann

Dear Chrie,
Thank you verv much for your kind invitation to participate
in the International Centerence on Drug Abuse in November, 1970 at
An Arbor. I am pleased to accept and look forward to the symposium.

the format of the suggested program, I believe you
role of the narcotic antagonists in the
treatment of opiate dependence, particularly in the treatment of juvenile
abusers of opiates. As a suggested title, I would offer Treatment of'
Opiate Dependence by Narcotic Antagonists or the more general title,
Opiate Antagonists and Heroin Dependence.
From

would with a discussion of the

by
M.

In this presentation, the final report will be c0*authored
associates, Drs. Alfred M. Freedman, Richard Resnick and Arthur
Zeke, all of the Department of Psychiatry of this college.
my

Again,

my

thanks for your kind

invitation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

,.wm

-..v~—.»~an-nmv-

�</text>
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                    <text>'7
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July 31, 1970

"im‘véibmu-‘F‘Usv'ﬁ‘vsvm

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rm

ﬁnger,»

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ﬁfiss Josephine Baeala
Executive Socretary

NCPS

San Francisco

'x-vmmgz—wv.

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Dear Miss Beale,

v7?

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51.2;

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«a

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Dr. Michael Taylor is one of the best qualified residants
to have graduated our training programs. He has a brilliant future
ahead of'him, if he disregards the frivolous dbmando of organized

medicine ana ps~zzchiatry.

a resident, he
intelligence above his pairs.
Ag

pleasure to see him assume responsibility for patients and
for nis research projects. He shared the 1989 research priae of
the society for Biological Psychiatry with a fbllom rcaidknt.

was a
m~ww17ﬂxi¥fff

I am pleased

{1552!}

raw-“r

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initiative, industry and
is sincere and honest and it

showed
He

to

recommend him to the

society.

Sincerely yours,
[jaw Fink,

33!.

Do

Profhaaor of‘Psychiatry

mﬁ/

�</text>
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                    <text>r,

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July 31, 1970

"-mwmwrwmn-

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Dear Mrs . Davidoff,

studies of lactate in anxiety were undertaken last
year, and confirmed the observations of Pitts and McClure. Since
we added very little that was new, we did not see the need to
describe our observations in detail, and simply published a
letter confirming the fact that we were able to replicate the
Pitts and McClure experiment in every detail.
Our

'

Pitts suggested that therapeutic trials with propranolol
we have not undertaken this experiment.

might be tested , but

Unfortunately, this observation is not in the
popular eye and I know of no one in upstate New York doing this
type of work. Dr. Gross of Indianapolis has examined the theory,
and has written a severe criticism.
Sincerely yours,
Max

Fink,

31.13.

Professor of Psychiatry

m

f/

Linda Davidoff MA .

St. Joseph '8 Hospital
symcuse,

New

York

�</text>
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                    <text>July 28,
Congressman

M.

1970

Biaggi

of Representatives

House

Washington, D.C.

Attention:

Mr.

Peter Ilchuk

Dear Congressman Biaggi:
In response to the telephone request of Mr. Ilchuk, I an
pleased to enclose a copy of a summary "Narcotic Antagonists
in Opiate Dependence”. The meeting was held on June 4, 1970
and was attended by the principal research scientists working
in narcotic antagonists.
They concluded that continued studies of antagonists are
important, particularly as they represent the principal, logical
treatment method for opiate dependence.

There is need for a more coordinated approach for

study.

this

Should you be interested in additional information, I would
suggest that you inquire of Dr. Bertrum Brown, the Director of the
National Institute of Mental Health, Dr. Peter Grey of the Vera
Institute (who has done an intensive study on this problem for
Mayor Lindsey in the spring), Dr. Henry Brill, Director of Pilgrim
State Hospital (who recommended the support and encouragement
which we are now receiving from the New York State Narcotic
Addiction Control Commission), Richard Severo or Joseph Lelyveld
of the New York Times, both of whom have worked on the problem,
or any of the scientists listed as attending the meeting. It
may be useful for you, on behalf of the Congress to carry on
a more public investigation of this interesting and potentially

very useful treatment of opiate dependence.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MP

:kt

611C.

�</text>
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                    <text>Tim

C"

',
F,-

a
“a.

“macho,

July 29, 1970
Mr.

Saratella

Xerox Corporation
New York, New York

Saratella:

Dear Mr.

I am sending you seven books of computer data to be
photocopied and bound. As you described, they are each to
be bound on the tap edge, like the data book. As I need
different numbers of copies for each book, please noteza
4 Drug

Stony Regression Analysis

Thiothixene Prolonged Studies

—

~ 5

3

capies

Tniotnixane Study Regression Analysis

-

~

2

copies

Placebo

~

5

copies

PCP 250 mg

~

3

copies

75 mg

~

2

copios

S

GP

4 mg

—

I would like to
possible.

capies
~ 3

copies

have these picked up Friday afternoon

Sincerely yours,
Max

Fink; M.D.

Professor of Psychiatry

MF:kt

,

if at all

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11‘

July 23,

1970

Mr. Robert Marlin

Sandor Pharmaceuticals
New Jersey 07936

Hanover,

Dear Bob,

Separately I am sending you a summary report and statistical
data of our two EEG studies of 8 42,548 in volunteers. In the
reported December 22, 1969, we defined a dose of
first study,
8
4.0 mg of 42,548 as adequate to alter the behavior of our
volunteer subjects.
'
'

NMQ—‘l’ﬁfﬂk

‘JW‘E‘M’E;

w

.-

,
,

Nvi-mu

we"

mm?»

In the second study, reported here, we compared the EEG
profile of 8 42,548 to placebo. While many differences, particularly
in behavior and systolic blood pressure were observed, we were unable

to establish an EEG profile. As we discussed, the failure may relate
to the sample size or dose of 3 42,548 ~ or to the possibility that
its central effects are variable and unsystematic (at this dose).
There are two options that are of interest to us and meet
some of your needs. One is to extend this study by additional

subjects at 4.0 mg or by an additional 6»12 subjects at 6.0 mg,
in comparison to placebo, following this design. This will either
demarcate an EEG profile, or failing to do so, satisfy the
statisticians who may question our sample size.
The second

is to accept this data

and proceed with a

direct

comparison with dextroamphetamine in a larger sample. This compound
was the principal comparison in animal studies. If we define a
profile for dextroamphetamine and not for 8 42,548, we can be confident
that the CNS effects of 5 42,548 are less than amphetamine. Failure
to define a profile for dextroamphetamine will raise doubts as to
our technique.

�-.-

:

'wwvw'wv—w‘mmvm.

z.,——_r.1x'_mu._—nw_,.\. V.‘,.,_.............n. we..-” ,_..

.w

V

.. ..v

”a", ,..-, we- . .._

we

_

is

w:

7

‘—

.—

mew.

Hr. Robert Marlin

July 28,

—2—

1970

rxu'vrv-Wii“

1'Vrtrm“w"w~

(a

Imitasmr

TWVSI'W’V

WWW,“

"'4

ym'r.‘

Before concluding the present study, however, you may wish to
arrange a review of our data with other investigators of 8 42,548,
both within and outside Sandoz Pharmaceuticals. I am leaving for
my holidays in August, and would be pleased to participate in such
a meeting in early September.

statisticians to
their analyses of the data, trusting that their results

I would also be pleased to meet with your

review

are similar (but hoping they find

more

than

we

did).

Incidentally, the study took much longer than I anticipated
Now
largely by our need to improve our statistics and programs. with
that these are fully operational, I am sure we can proceed
greater ease.
My thanks for your cooperation in this study - and my best
regards.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

Mszt

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                    <text>—

m-vr»

,

July 26, 1970

.N

11-7

a;

urnmw-J

Mr. William F. Buckley,

New
New
"rﬂvnl.ﬁ4'mr‘m

York Post
York City

Dear Mr. Buckley,

I have read your columns with interest and for the
time decided to answer what may have been an appeal. In your
column yesterday, you write that the drug problem is
literally
engulfing us and " not one living soul has suggested a program the
results of which would guarantee a diminution of the curse . . ."

first

There is one program which is nascent and which has
the promise to reduce the addiction rate in much the way that
other immunization processes have reduced the incidence of infectious
diseases. I refer to the use of opiate antagonists in the treatment
of opiate dependence, and the feasibility of developing a long term,

injectable or implantable antagonist which would be particularly
useful in “immunizing" susceptibles, particularly among
the very

we?”

young.

The program

is generally ignored

industry, although there has been

some

by Washington and
New York

support from the

State Narcotic Addiction Control Commission.

written in the press so that the only data that is reliable islittle
in
the scientific press. The summary of the meeting held in New York
on June 4, summarizing the available data, is to be published in
There has been

a forthcoming issue of Science.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>July 24,
Dear

we

1970

Peter,

thank you.

Your schedule for our

visit is

most agreeable and

are arriving in London on Tuesday evening, August
on the day flight. We are scheduled to leave London at 1500 on
KLM 132, scheduled to arrive in Amsterdam at 1555.
We

4

I ask your help in a small matter of concern to
I have received a letter from an applicant for
my Department
a fellowship in our laboratories, Dr. Paul BriEt. I have taken the
liberty to invite him to meet with me during my stay in Holland. If
he calls your office, would you arrange that he and I meet for about
an hour, at a time least inconvenient to you and Dr. Quantock ?
Many thanks.
May
?

I look forward to visiting next month. Martha and the
girls send their best regards.
Sincerely yours,
Max

mf/

fxayg~

Fink, M.D.

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                    <text>MAILED

T0:

DR. DOROTHY DOBBS

1600 s. Eads
Arllngton, Virginia 22202St . ’ Apt'

432N

_

July 23,

1970

Dr. Dorothy Dobbs
Section of Neuropharmacology
Food and Drug Administration
Washington, D.C.
Dear Dorothy,

It was a pleasure talking with you today, and finding that
views
on the proposed guidelines for drug evaluations were
our
essentially in agreement, reassured

me.

Thanks.

Enclosed is a copy of the summary of the June 4 meeting on
Narcotic Antagonists in Opiate Dependence. It will be published
in Science. The participants included clinicians, pharmacologists
and chemists with experience in the antagonists. We concluded that:
(l) The antagonist model was both clinically useful and theoretically
interesting; (2) Available antagonists, cyclazocine and naloxone,
were safe and further studies should continue; (3) A long-acting
antagonist was the ideal immunizing agent and every effort should
be made to enhance such a development.
We are continuing our clinical studies of cyclazocine; have
been reassured (after much difficulty [see New Yerk Times, August 14])
of our supplies of naloxone for one year; and have contract support
from the New York State Narcotic Addiction Control Commission to
develop a long acting antagonist. (We also are continuing a methadone
maintenance program and are studying the duration of L-alpha—acetylmethadol,
using heroin challenges as our index of duration of cross—tolerance.)

FDA

It

would be an honor, and

committee program.

There

interesting, to participate in the
is surely need for continuing evaluations

of the methadone and other opiate treatment programs. My curriculum
and I have been cleared for U. S. governmental

vitae is enclosed;

activity.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

enc.

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                    <text>5,.

n
V

W’Whjﬂ'.m1rn

July 23,

.
.y;

1970

raw

01"

Dear Dr.

Briét,

warm-”’3;

I have received your

"NWT/"Ll!

,
7.»,

LM‘M'YW“

r-

letter enquiring

about a

position in the Department of Psychiatry to study computer
applications to electroencephalography. Your suggestion interests
us, and I would be pleased to discuss it further.

,._,

wan-,mvﬂyz

«w:

Conveniently, I plan to be in Holland early next
that you plan to meet me to discuss your
questions. I will be in 089 from Thursday, August 6 to Sunday,
August 9 and will be staying at the Motel Nuland. It would be
best for you to call my host, Dr. Peter Fell at Organon
in 053 (04120-8433, and explain that you would like the opportunity
to meet me at a time most convenient to Dr. Fell and the party

month and I suggest

at

Organon.

Sincerely yours,
Vt:

’mr

Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>-

July 23, 1970
Dear Charlie,
How about skiing in Aspen in January ?
As hot as
and on the eve of holidays in Europe, it is time to think of the

ski season.

Richard Rech of Dartmouth has been asked by the
organizing committee of the Brain Research conference group to
organize a session on BBC and drugs in animals and man. He is
inviting willace Winters and himself; I suggested that you and Turan
be invited as well.
Would you care to discuss the EEG studies in man and
animals, their correlations, similarities, etc. ? He would like
to focus on the theories of EEG and behavior (association, dissociation)
and your mission, if you accept it, is to bridge the gap between the
animal workers and Tursn and myself.

Date: January 18, 1971
Meeting: January 16-22

Place:

Wildwood—at-Aenen

~r

-

-:»-:~v

‘(

See you in Prague.

“1...“:[2'

U'!"f'ﬂ’lrﬁi&lt;'f:5'l

-

.1'17&lt;

0.1

"a:

n-

an.

guyrmwu

it is,

Max

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                    <text>July 23, 1970
Dear Turan,

Skiing in January

?

Richard Roch of Dartmouth called to invite a program
group in Aspen for 1971. I suggested that
would
be
pleased to present your findings on the EEG effects of
you
psychoactive drugs on the sleep EEG. The focus is on the correlations
of EEG in man and animals. He is inviting Wallace Winters and himself.

for the Brain Research

923WL

‘57

.

Vim"

I suggested that Charlie Shagaas present data bridging man and animals;
I would do the awake EEG and would you take the sleep EEG ?

"5‘51“:

m7

The focus could be the

effects of indole
The

4ms=rmw

and

hallucinogens, particularly the

anticholinergics.

date: January 18, 1971

Meeting dates: January 16-22, 1971

r-v-

'v

Place: Wildwood-at-Aspen

(I will

be taking one or two of

my

See you in Prague and
My

children. ﬁring

Kurt and

Istanbul.

best.
—Sincerely yours,

Max

Ellen.)

�</text>
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                    <text>July 22,

1970

Dr. Joseph Cochin
Boston University School of Medicine
Department of Pharmacology and

Experimental Therapeutics
East Concord Street
Boston, Massachusetts 02118

80

Dear Joe,

Enclosed

is our

check as reimbursement

for expenses for

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.
You know that the
published in §gience.

summary

much

of the proceedings are to be

Also, I am sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial "responsibility”,
called DuPont - and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
My

best regards for a pleasant

summer.

Sincerely yours,
Fink, 32M).
Professor of Psychiatry

Max
HF

:kt

enc .

�</text>
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                    <text>-m mr—vmv.W

mwl"-IWW—nw—m

July 22,

1970

Xerax Corporation
295 Madison
New York, New York

Attention:
Dear

Mr.

Saratella

Sir:

Please make six cepies in reduces 3 1/2 xrll of our
records marked ”onepin 0ra1 Study”. Please collate.
Please

bill

me

at the

above address.

Sincerely yours,
“4.3.x

Fink

’

:1. r)

0

Professor of Psychiatry

HF:kt

wwwl‘qw—‘W

�</text>
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                    <text>July 22,
Dr. Jerome H.

1970

Jaffe

Department of Psychiatry

University of Chicago
950 East 59th

Chicago,
Dear

Street

Illinois

60637

Jerry,

Enclosed is our check as reimbursement for expenses for
the June 4 meeting on narcotic antagonists. I very much
appreciate your participating.
You know

that the

published in Science.

summary

of the proceedings are to be

sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility”,
called DuPont and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

am

—

My

best regards for

a

pleasant

summer.

Sincerely yours,
Max

Fink,

35.2).

Professor of Psychiatry

HF:kt
enc.

�</text>
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I"ua-~' . .«u “v. mw-vvvw-v-

»- v

vwmvr-r

w

y. .nmm.a._—~..V".—r*WWV~V§~‘FV.m——,*WLKAV , ‘vr.n.-Y'.-~,VJI=V

Wynn”... ._.. "a.

w ”p-

w.“ w:

,.-.«axf'lf:~9‘l‘lvv

July 22,

&lt;.-,,-,..

1970

.-

'a-rw

Ina-2v"

w‘mwwnww-r

“WI?

-

“xv-yrswr‘nvn

Dr. Louis S. Harris
Department of Pharmacology

University of North Carolina
School of Medicine
Swing Building
Chapel Hill, North Carolina 27514
Dear Lou,

Enclosed

urn-t

mn-wmw:m~‘u4~rzrnnﬁwv

check as reimbursement

that the
Science.
in
published
You know

for expenses for

summary

much

of the proceedings are to be

sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone fer clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial "responsibility”,
called DuPont - and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

mﬁ-‘l—HHHYWH“'mzwr1aﬁs‘n‘uV.-

is our

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.

My

7"mM'vvrnv'c

am

best regards for

a

pleasant

summer.

Sincerely yours,

'I'

wu'zm-‘w'

”ﬂ

r-vv,

Max

w

raw-mime»

‘j’

Mpzkt

ufn-T'vv

”rum

-

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K‘Oim-ﬂ.

Fink,

M.D.

Professor of Psychiatry

enc.

.u

m...”

.-er‘:l‘b'w

�</text>
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FYWQV“

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.

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»

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July 22,

1970

Dr. Sarnoff Mednick

Street

2 Perry
New York, New

York 10014

Dear Sarnoff,

Stanley Feldstein recently brought to my attention his
failure to request a honorarium for your visit to us, too long
ago. Please accept my personal apologies for we did not usually

Operate

this

way!

thanks for your lecture, and
continued success of your program.
Many

my

best wishes for the

Sincerely yours,
Max

Fink, 54.0.

Professor of Psychiatry

MF:kt

enc .
.

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3J4!"

WUJ‘JMFA

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4

,

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              <elementText elementTextId="98311">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
