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                    <text>*

,

annwn—mm.w_ww

,

I'W

~WIR

March 30, 1970

Dr. Sidney Malitz
722 West 168th Street
New York, New York 10032
Dear Sid,
The request of Dr. Joseph Meiers for a volunteer task force
of psychiatrists to support opiate dependent subjects in the
community using methadone was reviewed by an ad hoc subcommittee
of the Committee on Biological Therapies of the New York Society
for Clinical Psychiatry.
We

are aware of the public need and demand for care, but we
direct action be taken by the Society at this time.

recommend no

To recommend a single treatment model in a condition as
complex as opiate dependence is not satisfactory. The apparent
need is for recommendations regarding the applicability of an
apprOpriate therapy for each case, i. e. , substitution therapy

(methadone, heroin), antagonist therapy (cyclazocine, naloxone),
withdrawal and rehabilitation, group therapy, etc. To document
such a recommendation is complex and may be undertaken by the
Society. However, the issue is of national, not local concern

alone, and an APA task force may be a more appropriate body to
provide the necessary resolution.

The subcommittee, aware of the motivation for Dr. Meier's
motion, suggests that the Society review pending Federal legislation
(particularly HR 13743 and Senate 3562) to lend support to those
aspects or bills that may serve the interests of Dr. Meier's motion.

Respectfully,
Fink, M.D.
Professor of Psychiatry

Max

MF

:kp

For Drs. A.

M.

Freedman,

M.

Nyswander and V. Dole (ad hoc

consultant).

�</text>
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                    <text>”v»:-‘.-w»«;.u-..-g

”mnt'n‘:

any!

(«mu-‘WWW v...

.

—w0'ﬁm”'—m wwwmmwmscmxw

-,~

‘

or.

Mow

ﬁnnnuol Parlnuttor
York limos

m

3a.

1979

new York, Ron York

Door

ﬁr. Porlauttor,

Your article reporting acoroooototlvo attlogor'a plan to
introduce a bill “. . . to Fight Youth Addiction” (av? 3/29, pg. 61)
is misleading in associating ruporto of‘horoln and unsuish under a
single addiction hoaoing. Tho rtuort doocribos a program to control
heroin adalotiou; includes, without o.brook, a roport on arroats for
hashlsh; and concludes with c tooort of two docths ascribed to heroin

ovordocago.

Tho sanéwlchlng of hsohlih botwuoo two atories of heroin undo:
a single addiction title associatos two alsparoto drugs under coo
opprohrlous title, and is not up to tho yroﬁhsaod standards of the
Row

York

limos.

l. Hashish is not horoin, is not an opiate, ls not dopendenco
producing, and has distinct pharmacology, chooistry and offbcts on
tissue: (ruforonccs may be supplioé). one could oaks as good a
caso for associating ethyl alcohol god oulatos, as cannabis and opiates.
2.

There is no proven biological tssocintiou between the two

drugs. All associations are legal and social.

3. The confusion ongondoroé by equating the two drug classos
oncourngos mlslntorprotatloua by the goblin. Lawyers weaponsible
for low: equate cannabla and opiates (sou the omnibus urug Bill

Earljuano users are rooortod to try horoln
of addiction when marijuono importation is
risks
attending
its
curtailed. Criminal gonoltloo for too abusa of‘tho two drugs or.
often confusod.

gauged by the $onoto).

with

sincerely yours.
us; Fink, ﬁ.5.

Professor of Psychiatry

2%?

:kp

bcc:

A. O.

Sulzborger

be encouraged to review the differences
in drugs with some scientists. I imagine a seiinar in clinical
pharmacology would be useful. It can be arranged.
Your

staff

may

�</text>
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                    <text>w
-..

v

«gm-wr

A

Mm...»

March 26, 1970

Dr. E. Leong

Way

Department of Pharmacology
University of California Medical Center
San

Francisco, California 94122

Dear Ed,
'
""‘

"‘

"
“r“

"(w-39?"

ur..-.w;,;--ur-=-

yumv-yum)

m“,

y.

*‘1'

"11W“

interested in the catechol amine theory of
and read your 1969 NRC report with interest.
In discussing the possible mechanisms with Doris
Clouet, the
read from your review for her book, and I am
writing
to ask
you can make a copy of this summary as well as other relevantif
I have become

opiate dependence,

reports available to

me.

Your data suggests

that serotonin
like
cinanserin, may reduce opiate dependenceantagonists,
(and opiate drive?)
in post addicts, and if this is possible, it should be
tested
in man. Have serotonin antagonists
been given to post addicts?
With what results?
Many

thanks.
Sincerely yours,

«-

..

uyyyv.’

mgmn

Max
‘:

'
awn:

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>March 26, 1970

Dr. S. Clyde Strickland
Herck Sharp 5 Dohme
West

Point, Pennsylvania 19486

Dear Clyde,

have been notified by the FDA that INU 5590 dated
March 30, 1970. has been issued for our study of £~a1pha~
acetyluethadol. Enclosed is an IRS 2513 for 20 Grams.
We

Many

thanks for your cooPeratlon.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>”r.‘me-WVM7

-

yam

w-

March 26, 1970

Dr. E. Leong way

Department of Pharmacology
University of California Medical Center
San

Francisco. California 94122

Dear Ed,

interested in the catechol amine theory of
Opiate dependence, and read your 1969 NRC report with interest.
In discussing the possible mechanisms with Doris Clouet, the
reed from your review for her book, and I am writing to ask if
you can make a capy of this summary as well as other relevant
reports available to me.
I have become

Your data suggests that serotonin antagonists, like
cinanserin, may reduce opiate dependence (and opiate drive?)
in post addicts, and if this is possible, it should be tested
in men. Have serotonin antagonists been given to post addicts?
With what results?
Many

thanks.
Sincerely yours,
Max

Fink,

%

D

Professor of Psychiatry

Mszp

�</text>
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                    <text>.T. 1,,” 3,.”

var

‘,».,

ﬂu, -

m...-W. w...“ “Arum“ "haw ~.:W_4..mw‘.rywn-ww~ .-...v~.-m",

,

rm

tnw

.

”mm.

.,

‘

w...

.m

._w~w..lm.—mm

'w-nqr'mmir-r‘w

March 26, 1970

Dr. A. Dlmascio
Boston State Hospital

Boston, Massachusetts

02124

Dear A1,

his oo-workers, Drs.

Robson and Castanaga,
the meetings on child and
adolescent psychopharmacology. I was most delighted to hear
Dr. Simeon and

were very much impressed with

fine presentations, particularly that of Don Klein.
Congratulations and many thanks for permitting my staff
to attend.

of the

many

'

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>WWW

March 26, 1970

Meditoch, Inc.
65 Rogers Street
Cambridge. Mass.

Gentlonon:

and

I have read the report of your automated patient interviewing

clinical laboratory reporting programs for hospitals in the latest

issue of Computerworld, and would bo interested in obtaining any
public information regarding the availability of the programs,
whether their input may be adapted for psychiatric use, and the
charges for programs and/or services.
Many

thanks .

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 25, 1970
Mr.

Earl Ubell

CBS—TV

New

Dear

York, New York

Earl,

have been requested by an assistant of Dr. Stanley
Yolles, Director of the National Institute of Mental Health,
to make available any visual material concerning our research
We

presentation to the White House. I would be grateful
available copies of the naloxone and
marijuana reports, both of which I consider excellent
representations of our work.
for

a

1F you could make

I am most

grateful ion your cooperation.
Sincerely yours,
Max

Fink, %.ﬂ.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>a“...

.—

m—w‘.‘

-

-wm“

—.

«nu-m”!

W"

W“

'March 25, 1970

-

San Francisco Hilton

Mason and

O'Farrell
California

San Francisco,

94109

Actuation: Raservation Manager
Dear

Sir:

With regard to my reservation for May 7. I will be arriving
on American Airlines Flight 15 which is scheduled to be in
San Francisco at 10:00 p.m. Please change checkain timc to 11:00 p.m.

Sincerely yours,
Max

Fink , Md}.

Professor of Psychiatry

�</text>
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                    <text>March 25, 1970

Dr. William Guy

Biometric Laboratory,
1145

washington .
Deer

Rom

618

Nineteenth Street, N.w.
D.C .

20036

Bill,

called your office yesterday and spoke to Ron regarding
that we needed. Enclosed is the formal request for
the forms which I asked to be shipped yesterday.
I

some forms

I also inquired about the status of the data of our ARR-1900
study and Ron was surprised when he checked our file for he stated
thet nothing was due. He clso checked the files for Dr. Simeon
and the same was true. On December 4., Dr. Simeon sent the date
of our study. I would appreciate your checking.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

�</text>
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                    <text>March 23, 1970

rr’.

w.

w—

Dr. John A. Sclgliano

Executive Secretary (NIﬁH)
Psychotomimetic Agents
Advisory Committee
FDA—NINE

Center for Studies of Narcotic and Drug
National Institute of Mental Health

Abuse

5454 wisconsin Avenue

Chevy Chase,

ﬁatyland 20015

Dear Dr. Scigllano:

Enclosed is a progress report of our work, a record
of the usage of marijuana, and a copy of the IRS Tax Stamp.
each.

Qur present schedule anticipates 40 experiments, 1-1.5 Grams
We would like to begin in mid—April and work
through the

summer.

If available,

may we

request

100 Grams

marijuana of

potency approximately equivalent to our present sample, VINE-l?

Sincerely yours,
Max

Pink,

”.9.

Professor of Psychiatry

MP

:kp

enc.

Tax Stamp

Progress report 3/1/70

Use

of Murijuana

�3/23/70

RECORD OF MARIJUANA USED

12/4/68
12/18/68
1/15/69
4/18/69
11/29/68
12/6/68
12/20/68
1/22/69
1/29/69

.
.

17.0
11/10/68
through 11/26/69

(1.0

1

Gm/day)

3/2/70«3/S/70 4.0
(1.0 Gm/day)

Gm

2.0

Gm

3/6—3/11/70

3/5v3/6/70
3/5/70
3/6/70
10/31/69
7/28/69

3.0

1.
1.

Gm

G

»

.0
0

�</text>
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                    <text>March 21, 1980
Dear Andy and Betty,

very much

for our

Congratulations on Deborah Jane's arrival ! I
name Deborah, and in fact, Martha and I used
daughter, Rachel Deborah.

like the

first

it

I look forward to seeing you in Prague, for indeed,

planning to attend, having been asked to monitor a program
in hallucinogen and amphetamine abuse. I am not sure that my
family will be with me, for I am planning to get a house somewhere
on the Meditteranean and spend many weeks away drom work. I
have a project proposal to study marijuana in Athens, which is
before NIMH and if they consider it useful, they may fund it
before the summer.
I

am

_

The family is well. Jon is away at Colby College
and
we
hear from him every few Weeks. He is a ski
in Maine,
and
seems to enjoy College between ski runs. Martha
enthusiast,
is enjoying her teaching; the girls seem to survive the many
crises of young people.
’

is progressing well, despite a very hectic
college is planning to move from Manhattan
organizational situation.
Our work

.
,._

news",

..

.7,

1:1,“

.
v.—

Our

to Westchester, and while we thought it was many years away, the
realities of our economy forced the school to decide to move as soon
as possible, preferably before 1972. So, we are involved in planning
programs in Westchester; moving part of our Department to the
new Mental Health Center which should open this winter; and keeping
up with the demand for service—- particularly since we are involved
in studying and treating Opiate dependence. In this period of
rapid growth, I am sure that we will be able to find a place for you.
(I forgot, we also have a new relationship with our local state hospital,
and one of my students has become the Director. I am to assist them

in setting

up a

center like MIP).

.«.-.A..-‘.w.-«.r..

best study has been our ECT work. We have
that unilateral ECT does indeed have less memory effects than
The

wr-H

'YI’vy‘W

Tani—,1

«pwmw

In.“

‘74-“

I'_".'r.w

found

bilateral, with

Hoppital, where we are dning the study, is planning to visit South
Africa in late April or May. Dr. William Karliner is an excellent
clinician, and you may enjoy having him visit with you and those of
your associates interested in ECT. I will give him your name,

trust

he

will call.

brother. He
return
enjoyed his trip very much and is saving busily to
trip. Indeed, he has tried to seduce my family into talking me
into going to Africa—~ and perhaps we will.
‘

”Ruin:

.
.

.

w_w

IVL'E'W

-rm-—

clinical response. This has encouraged

try multiple treatments in one sitting, and we now are examining
the possibility of treating depressive patients in 3 sessions, 4 seizures
each (so-called multiple monitored ECT). It is quite successful, and
the anticipated memory effects are just not observed, even on sophisticated
tests. Incidentally, one of the practitioners at Gracie Square

us to

and

'rPV'nr-a'“rmvsp-

almost equivalent

dinner in Prague.

Many

thanks for discussing

Keep up your work, and
Mv

SA

with

my

make a

I look forward to

hear rewards: to which Martha adds her

own.

�</text>
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                  <elementText elementTextId="105821">
                    <text>March 21, 1970

Prof.

H. Lechner
Graz, Austria

Dear Helmut,

IBM

is

have programs for period analysis, power
spectrum, and amplitude analysis, as well as aleep programs.
Difforeut methods are useful for different problems, and
I would be glad to advise you if you will describe the problem
for which you wish to quantify the EEG.
We

work.

Ev

am

sending you some reprints of our

beat regards.

sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

33',

gr

\

Separately I

If I have the Opportunity to spend some time
in Europe, I will surely try to visit Graz~~ hopefully to
try sailplaning with an expert.

:.

z

it

methods.

rmrvwaawu—avmw

.4

Our method of EEG analysis is based on an
1800 system, which was put together in 1965. For 1970,
too expensive and I would not suggest you try to use our

..

�</text>
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                    <text>\March 21, 1970

Dr. Mohammad Rashid Chaudry
83 Shah Jamal Colony

Lahore, Pakistan

Dear Professor Choudry,

It

of you to write about the tbssibility
Nadees. It is my understanding that his
training director will permit him 2 months time away from the
College this summer and, if he wishes to undertake a longer
project, to do so next year for 6 months.
of a project with Dr.

,I

was kind
A.

believe that

do

2

is too short to
setting, but I am

months

accomplish any meaningful mission in a new

delighted to cooperate by suggesting a number of projects which
he could examine with your staff; and if the proposals are
satisfactory to you as well, we can try to do as much of the
peeliminary work here, so that his six months sojourn may be most

useful.

which we

Among

the possible projects are the following,
him, and he may examine in greater

will discuss with

detail with you:

A

comparison of

unilateral

and

bilateral

ECT:

are particularly interested in the new techniques of delivering
ECT within 3 sittings, usually 6 days. The technique, called
multiple monitored ECT (MMECT) is quite successful but needs a
larger population for validation.

We

An evaluation of concentrate vs. capsule
phenothiazines, with blood level monitoring in the treatment of
schizophrenia.

Treatment of acute schizonhrenic patients with

cupriming~— a

chelating agent.

available,

If opiate dependent (heroin, morphine) are
are particularly interested in the use of antagonists,

we

and these may he made

agree.

available for experimental purposes,

if

you

There are other projects as well, and these may
be discussed with Dr. Nafees. I will give him some reprints of
our work as Well as some preprints and protocols of ongoing
studies so that you can see the projects in the context of the
ongoing work.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 21, 1970

Grune

&amp;

Stratton

381 Park Avenue South

New

York 10016

Gentlemen:

on

my

Kindly enter a subscription to
behalf, effective with the January,

annualyy

Comprehensive Psychiatry
1970 issue, and renewable

until cancelled. Please address the subscription to

office at:

Max Fink, M.D.
39 Arleigh Road

Great Neck,

New

my

York 11021

Thank you.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�March 21, 1970

Headley Bros. Ltd.
Ashford, Kent, England
Gentlemen:

I should like to reinstate my subscription to the
British Journal of Psychiatry, beginning with the January, 1969
issue, if that is still available, and continuing annually until

cancelled.

Please address subscriptions to
Prof.
39

Max

Fink,

Arleigh

Great Neck,

1969

my

home,

M.D.

Road
New

York, U.S.A 11021

receipt of statement, I should like to
subscription and prepay 1970—1971.
Upon

pay

Thank you.

Sincerely yours,
Max

Fink,

M.D.

for the

�</text>
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                    <text>,W’
M7

5“

March 21, 1970

fr. Richard de John

146 Main

Street

Maynard, Massachusetts
Dear Mr. de John,
We

(a,
:—

.y_

a“,

mid-15‘»

V’ﬁ'ﬂ‘wmﬁnwn

4-:

yuamwm-ni

'1

wsw

w-

”-1;

"w

WW

met during the Aspen Brain Research conference, and

I was very impressed with your presentation. Since then, I have
investigated the various problems in my laboratory, and I am
writing to obtain your cooperation in the following problems.
My present work is focussed on the analysis of EEG
signals in real time by period analysis. Our programs also permit
power spectral analyses and sleep prints. Outputs are by

The data
printer and on scope. The work is not interactive.
and
then played back in
is collected in various centers on analog tape
The
treatment,
statistical
the computation center.
outputs undergo
used.
and for this card outputs or disk are
Our present configuration is Grass polygraph Model 7;
Ampex SPSOO; and IBM 1800 (2 disk drives, 16K memory) printer).
The questions: For our present applications, what is the

appropriate configuaation of the
To

ﬁ/‘u‘v‘r-K'rai'qumuwmwvs"v-xaﬁ'u‘ur'I...

facility

-—

*mvrmnwwv—

'T‘”

at

what cost

7

transform our present programs,

what may be a reasonable cost
x

PDP—lZ,

7

I would appreciate the opportunity to have you
to discuss this.
Many

visit!

our

thanks for your consideration, and your patience in Aspen.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/
*

or one of your associates/

�</text>
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                    <text>March 21, 1970
.A

‘
WW

‘w—Ww‘

Prof.

H. Lechner

Graz, Austria

-

Dear Helmut,

IBM

is

Our method of EEG analysis is based on an
1800 system, which was put together in 1966. For 1970,
too expensive and I would not suggest you try to use our

methods.

we

have programs

for period analysis,

power

spectrum, and amplitude analysis. as well as sleep programs.
Different methods are useful for different problems, and
I would be glad to advise you if you will describe the problem
for which you wish to quantify the EEG.
work.

Separately I

am

sending you some reprints of our

..
..

m

1-—.

...¢..,..,.,.,.,w.-Vw,

If I

have the opportunity to spend some time

in Europe, I will surely try to

try sailplaning with

an

expert.

visit Graz-- hopefully to

y.“

“y

My

best regards.

.

..~.-.—'r.-._..

‘~'wvv"n

mm-

Sincerely yours,

.m',--w“‘

mmM—m.

Wm'ycrw‘Tﬂw-‘ﬁ-ﬁ'l—‘mn'mw

:Rﬂ.‘r"‘:w

~

ro-mw—wn—u

.v—q:«.muw-«pwy-mewwaxwrap-1w

uwvw-w—w-

it

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Herch 21, 1970

..

A.

'Wr‘n:rv‘m.rz“r‘

Prof. Neil Burch
Texas Research
Houston. Texas

Institute of Medical Sciences

,.~,.v.m.-uww-,W~v;w;

Dear

Neil,

m.”-

-.—v

Iu'f'a‘rI/I-

W'ﬂ-m‘wvwlr“

v‘n‘

m-A

uwwu

-

x

‘mmzm-w

‘-‘DWVP'LV¢

Recently, I read of your repeat, Outline Classification
of'Pbegraph Responses, and I am writing to ask if you can rake
a copy available, or the citation.
continue to use period analysis and find it
useful. Is anyone else using it for EEG ? I keep reading about
power spectra for everything; and when that is not used, then
We

averaging

will
grateful if

Abrams
"Jn'r‘lw'nt-

.--_—-

a"

13

the technique of choice.

of my staff, Dre. Jovan Simeon and Richard
be at the VA meetings next month, and I would be
you would arrange for one of your residents to show them
Two

around; they are interested in seeing other programs.

1?

Mont

1mm

v‘

thanks, and

my

very best regards.

~=wz

m
.

Sincerely yours,

‘Z'w—AH—

V

Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>.m_ww.m

mmwm'wm

n—wrwaw

4‘:

«2-—

March 20, 1970
Mr. Max

Singer, Prosident

Hudson Institute
Quaker Ridge Road
Crotcn—on~Hudson,

New

York 10520

Dear Mr. Singer:
ouch has happened sinco I received your interesting letter
of notch 12. I appeared beforo Senators Hughes and Javits in
support of a proposed bill (S~3562) to establish a division of HEW
dedicated to a national effort in treating and studying drug
depondonce. Mr. Javita became interested in antagonists and
when

his office called

NINE, they were told that our
was rejected.

contract for a long acting naloxone

is to your questions.

present Facts or

dogma; but

unsolicited

Most are unanswerable according to
here are some tries.

”Craving“ after detoxification as a metaphor, “there is
nothing in his body which one can hope to influence”: There is

that tissue cells

change when exposed to opiates, and
a single exposure, are long lasting.
When animals are exposed to an opiate days or weeks after the
initial exposure, their response (however measured) is significantly
altered from the response of unexposed animals. Thus, opiates are a
some evidence

that

such changes, even

after

potent signal and ono~trial [or fow~trial1 learning occurs ~ with
consolidation of “learned“ behavior very rapid and persistent. Such
evidence supports the view of opiate dependence as a biological
How to induce “unloarning” or forgetting is our problem.
problem.
We need means to enable selective forgetting (g;g;, in such diverse
illnesses an phobias, allergies. penicillin and rﬁ sensitivity,
935;), and the “cure” of opiate dependence may be viewed in this
framework.
By the dictionary, it may not be a ”medical“ problem,
but it is a biologic, not a aociologic, problem.

�nw-w-v—IVWW

»V..-———-.wW——n..—..w

‘W~WW WWW—“WW""a... ,_
.

Mr.

w. .

.

,7 Wwe...

1..

pm_—w.wwmmm. Maw—.wm.

..

.

-2-

Singer

March 20, 1970

The problem with methadone maintenance (and

2

’

.

heroin maintenance)

is that these agents consolidate learning. A principal hone of
treatment by antagonists is that they may serve to reduce opiate
"memories.”

.

H

of ldroin Addiction: A spontaneous cure reflects
some subjects to resist tissue demands for opiates
fer sufficiently long periods to reduce tissue changes by disuse
atrophy. Whether the drive to withstand tissue demands is socially
determined (as in asceticism), physically (as in incarceration) or
biologically (antagonists) may be irrelevant to the outcome of
discontinued addiction. RAV is an interesting term that needs
clearer definition.
The Nature

the ability of

._m.ww_,m,uus

WV.

“Wu—A

.«

Hwy

«r
-.

..v7-—.r‘—vr”mMW-Irmv-——M

Heroin Use and Disease: Some interesting ideas, I have responded
with marginal notes, agreeing with most, and disagreeing with some.
1. A reason for reducing a habit may be expense and strain, but
this sounds like a rationalization. Perhaps, a reduction in drive
for opiates occurs because of hormonal changes (stress, age) or after
an illness which may alter tissue responsiveness.
2.

Like with other addictions, as alcohol, tobacco or barbiturates,
seems necessary to assure availability of the drugs.

social participation
shawl-

cw,-

:wgq.;n~v

Perhaps contagion is re—enforced in opiates because users know
To assure an adequate supnly, they wish to increase their
connections, so that if one connection is disrupted, others will be
available to sustain the dependence.
3.

it is illegal,

”pr

w—

.,

4.

Theoretically balanced, but is there any evidence?
had apple in the barrel analogy is applicable.

5.

Surely, [repeated] exposure to opiates is the necessary

likely, the
,wvwwrwrwmwl

and

sufficient causal factor.
These are

.‘y

”.7,”

More

my

responses.

Perhaps I

am

over-emphasizing the

biological bases of addiction, but this model seems to provide a
better theoretical framework for the study of your questions than
sociologic or psychologic theories.
I look forward

to your recommendations

- which I hope will
some other techniques

balance the psycho-mania and methadone-mania with
for study.
Sincerely yours,
rwﬁwww

:‘zax

Fink ’

:51. D

a

Professor of Psychiatry

Mszp

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                    <text>mm"?

March 20, 1970

Dr. Edgar Grunweldt
Geigy Pharmaceuticals

Ardsley,

New

York

Dear Ed,

Enclosed is our report, “Ketiprauine in the Therapy of
Depression in Outpatients”. Separately, I am sending case
summaries: cepies of all forms; the NIMH Biometric Laboratory

data analyses and duplicates of their output cards; and the
Biodata clinical laboratory outputs.

I regret the delay in completing this study and wish to
thank you for your patience and cooperation.
we would like to submit the report for publication in
the Journal of yew Drugs, if you have no objections. To do
so, I would appreciate a list of published references on
ketipramine, and as many of the reprints as you hay have
available, so that the study can be put in the proper context.

Again,

my

thanks.
Sincerely yours,
“or Pink, 3.0.
Professor of Psychiatry

Mkap
911C.

�</text>
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                  <elementText elementTextId="103248">
                    <text>~— -.v-;——vv--_~u~

Wuwww.wwn——.W.T— m—

mw

- «"I’w‘vwv‘w... «.m..- .._

.i-

.

.7

,

v7.7".

m”

r—- ___, ‘_.._m-——r——W-—-—rv—-—v—--—vww—w

"w.

a—
—

March

~—

i9, l970

Dr. Allen P. Borger
Chas. Pfizer &amp; Co.
Gro‘ron , Connecficu'l'
Dear Alien,
,
w“:

.
~

.‘w

.~

-

.wmwewvwmwfw.»

3.,ww-wwnww

'—

.—

Separately i am sending you The complefed dafa sheets
of +he doxepin—chlordiazepoxide sfudy. You have already
received the Biometric Laborafory analyses of this dafa.
i am enclosing the card ouT-pufs as
supplied by fhe Biometric
Laboralory for fhe use of your sfaficlans.
in addifion

Biodala, inc.

i

am

enclosing a laborafory dafa oufpuf from

Enclosed wifh This ioffor is a more complete final reporf.
This includes some fables no? submiflad To Currenf Therapeufic
Epseargh, Thu? report has been accepted for fheir April issue.

if

mifflwm‘”

has boon a pleasure working wifh you.

Sincorely yours,
.--.

Max

v

"3‘

,...

van.»

V-i.v

‘40.“.

v-

Fink,

M.D.

Professor of Psychiatry

aer‘I-err-ra'w-y—

MF:kp

�</text>
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                    <text>vv.‘.“‘l

-vw—~x'wl|‘i|"'-"1'~ﬁ~Vr

"ww:

March 19, 1970

|p';ﬂva-Tvrn

Br. Allen P. gorger
vagwwra.w--—ku.w

Chas.

Pfizer

ﬁ

Co.

Groton, Connecticut
”-

'x-u

.

Dear Allen,
As you will recall, Hrs. Simeon and Nikolovski
interested in treating the failures of the doxepin~

became

chlordiazepoxidc study (as well as the doxepin successes
after 8 weeks) with a ”stander “ drug. They selected
thiothixene and the enclosed short protocol is the
modification of the doxepin-chlordiazepoxide study that
they used. Also, enclosed is the summary of their
observations.
Separately I am sending you the case summaries, and copies
of the various NIHH study forms - personal data inventory, drug
study resume, brief psychiatric rating scale. clinical global
impression and treatment emergent symptom scales. The Biometric
Laboratory hes analyzed this data and their report with a set
of the data card outputs are enclosed.
The

v—w

-'

«saw-‘2‘"rr'wrnmzw

laboratory data

was analyzed by

their output is also enclosed.
Based on this information,

we

Biodata, Inc. and

have proposed a more

study. s protocol of which has been sent to you.

I onticioate submitting the
JOurnaZ of’th Drugs and I will

answer.

report of this pilot study to the
notify you as soon as I have an

“NI—Www'!‘

Again,

my

thanks for your cooperation.

rT

'rIir-.4i

definitive

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>w—vn-Lmvz

"W

March 19, 1970
Mr. Stephen Miller
WCBssﬁditorial Office
51 West 52nd

New

York,

New

Street

York 10019

Dear Mr. Miller:
am enclosing two sets of
narcotic antagonists and our proposal for
and the other on the proposed drug abuse

In response to your request I

information, one
a long

acting

legislation.
tried for

be

on

form;

preposal for a long acting naloxone should
a long acting cyclazocine as well.
The

With regard to legislation, 5 3246 has been passed Err
the Senate and now appears before the House Public Health and
Welfare Subcommittee of the Interstate and Foreign Commerce
The new bill before the Senate, 8 3562.
Committee as ”-13743.
the
response of a few Senators to criticisms of the
represents
administration bill.
My testimony and that of Professor Daniel
of Chicago are enclosed.

X.

Freedman

r

I

A-m—

1|“er

trust this iiformation is useful.

"r"

Sincerely yours,

&lt;

Max

Fink,

M.D.

Professor of Psychiatry

Mszp
one .

.

�</text>
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                    <text>March 18, 1970

Dr. Enoch Galloway

Chief of Research

Department of Mental Hygiene

The Langley

Porter Neuropsydhietric Institute

401 Parnassus Avenue
Sen Frencisco, California 94122

Dear Roch,
and I look forward to the program
Rework.
I am delighted to discuss the
you have set up in
neurophysiology of biological treatments and would be glad
to cover convulsive therlpy end/or drug therapy. It seems
November 7

is clear

if

Charlie discusses the changes that occur in
might be interesting to describe the changes
it
that occur with treatment and while we may not come to any
conclusions, the comparison msy he of interest to all of us.

to me that
psychoses,

the extent that it is relevant, I will include the
changes in the sleep EEG following these treatments, although
I hove not done the work myself.
To

My

thanks for your

invitation.
sincerely yours,
Max

Pink,

{‘50:}.

Professor of Psychiatry

�</text>
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                    <text>March 18, 1970

Dr. Henry

Brill

Pilgrim State Hospital

Box 22
West Brentwood, New York 11717

Dear Henry.
Thank you very much

in the Institute
on September 22.

on

for your invitation to participate

Hospital and

Community

Psychiatry Service

I would be pleased to take part subject

only to the reservation that my holiday plans are not yet
firm and I may be away during the month of September. In
that event, I would like to feel free to ask either of my
associates, Hrs. Arthur Inks or Richard Roenick, to participate,
since both have the most clinical experience with methadone.
Depending on how broad a spectrum you would wish to
present, I think the antagonists should he discussed as a
model and the problems compared to the problems for methadone
maintenance. I think one should also try to present the
methadone treatment in the 9:83pective of other biological

therapies, including heroin maintenance.
I look forward

to hearing

from you.

Sincorely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�March 18. 1970
Dr. Jose

M.

Musacchio

University Medical Cantor
Department of Pharmacology

New York

550

New

First

York,

Avenue
York 10016

New

Dear Dr. ﬁnsacchio:
I

am

pleased to participate in the pharmacology teaching
to discuss the ”Clinical Pharmacology of

program and propose

Oplote Dependence". I would like to present our approach to
the treatment of heroin addiction, comparing the pharmacology
of heroin maintenance, methadone maintenance, and cyclazocino
and MI oxone antagonism

.

wish to bring some
would be useful, however, not
I

may

Thank you

2 x 2

slides

and a smell

essential.

for your invitation.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry
(Soc. Sec.

Mszp

#

016~18-2080)

projector

�</text>
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                    <text>!

V

i

t

Marth 18, 1970
Dr. 0. Vine:

Psychiatric Research Institute

Prague 8 - Bohnice
Czechoslovakia
Beer Oldrich.

Enclosed is the abstract from Dr. John Griffith
will present in the ysnel "Pharmacological and Therapeutic
Aspects of Amphetamine and Hallucinogen Abuse".

who

John Davis has agreed to discuss the Friedhoff paper
in our symposium. He has written to me asking whether he
could present a full report of his work in the free communications
on amphetamines. Enclosed is his abstract. If the abstract cannot
be published with the free communications, I would be pleased
to have it published with the abstracts of our panel.

separate abstract was sent to me by Professor N. B. Essman,
asked that this be included in the free communications. If
space and time permit, his work is among the best in the v.5.
and I believe it would be interesting to our eenbers.
A

who

Sincerely yours,
ﬁe: Fink, M.D.
Professor of Psychictry
HF:kp

encs .
v

.

Firm-aw"

.

�</text>
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                    <text>l 3 1 1 11

.w-

~11

,

-n‘:'~'r-v

“r

uj'v

.

"7mm ~—..w.w—-—..—

VFW

,

v—"r-I—I—u

wwmmrF-m-V

n

mjw—W-._.m._v.wﬁ7-..."

----_....-mw-.ww.-w_1

V

m,7.....-A-..A-‘._._...._v--,-_

“Hwy",w,“

March

l7, I970

Dr. Wllilam Tabor
A. H. Robins Company
I407 Cummings Drive

Richmond 20,

Dear

Virginia

Bill,
if seems rldlcuious fo val? for fhe ﬁlamefric

revtew of

Laborafory

Separafoly, I am sending you Two books
confalnlnq fho date of AHR-IQOO - your sfudy voiume which
Includes our summaries, data sheafs and +ho dafa evaluation,
and our laborafory dafa output.
AHR-IQOO.

As

soon as The Biomefrlc Laborafory lnformaflon ls
I will
ship I? #0 you and wrifo a publicaflon

My

has? regards.

available.
report.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychtafry
Mszp

�</text>
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                  <elementText elementTextId="105825">
                    <text>"In—1m m.

2“,." . .,.»...m.\.....Mum-4...”....

-,,.-

_ ,

rrwuw-wwu-‘mmr-rm .- .—.._.....—_.w....

v.1,

r

,

.

iv"...

..

..~

ﬂ...

—_

-MW ”rm“. 2...“...W—W

..,,.

.7. ,.- N... 7....”

u 7.. w.

w

.y-.-

W.

v-wrﬁrm-

March

l7, l970

--

wvrw-w-z-L

To Whom

it

'»—w-

i
,.

.mg-wr—mﬂ.

am

May

Concern:

writing this letter in support of the application of

Mr. Peter lrwln for admission to medical school. i heartily
recommend his admission, believing that he would make a knowl»

edgeable contribution

m

sum-guw.

‘n-JN

e

'

”WWW

“Wu

Nam

hava known Mr. lrwin since January l968 when he Joined
my staff as a research fellow in lieu of military duty. He is
a registered conscientious objector. During the past 26 months
he has prograsslvely assumed greater and greater responsibility
in my research programs, evaluating psychoactive drugs in normal
voluntears. He has exhibited abllltias in interviewing and assessing
drug effects. both gross and subtle; he has developed a facility
in reading and analyzing the human electroencephalogram for
research purposes; he is capable of handling electronic equipment, including an lBM l800 computer; and most importantly, has
l

an

szwmwnwv

to medical science.

ability to relate to
He

is

a

members

of

«um—tr.”

staff.

personable young man, friendly and well liked.

At

has assumed responsibility
assertive.
with
and
good Judgment and for
sxoacitas
responsibility
gladly
confidential matters, with discretion.
times he is brash and

«an.

my

He

His uncle, Professor Samuel lrwin, of the University of
is a well known research sciantlst in psychopharmacoiogy.
His uncle's stimulation led to his working in this laboratory and
he has developed an enthusiasm for psychiatric research which is
commendable and which i have encouraged.
Oregon,

Wrpr'm—W.Y

pleased to racommand his admission for medical training
despite the apparent lack of basic science interest during his
early college career.
i

ra—u-

2

am

Sincerely yours,
Wﬁ'wi'l'm‘w,mﬂ_lwlw

Max

Fink, M.D.

Professor of Psychiatry
Mszp
.

..

�</text>
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                    <text>~w

March

l7, l970

Dr. Charles Shagass

Easfern Pennsylvania Psychlafrlc lnsflfufe

Henry Ave.

&amp;

Abboffsford Road

Philadelphia, Pennsylvania
Dear

Charlie,
Enclosed is a

ieffer

from Dexfer Ballard

consideraflon of the Membership

Commi++ee.

Sincerely yours,
Max

Fink, M.D.

Secretary

MF:kp
BBC.

for your

�</text>
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                    <text>March 14, 1970

Dineecio
Director of Psvchophnrmacology
Boston State Hospital
Boston, Massachusetts
Dr.

A1

Dear A1,

It was kind of you to recommend that I review your
Handbook oj’PwyohopharmaooZogy. I find
an excellent

Clinical
it
representation of prevailing opinions, and I am confident it
will serve a most useful purpose. I particularly enjoyed the
section by Sy Fisher, whose principles delighted me; and the
reviews by Klerman, Cole, Kornetsky, Friend and Ching~Piao.

interest to

section

by Allen Mirsky, holever, of particular
is out of keeping with the rest of the volume. Hie
animal data in a clinical volume allows the presentation

The

me,

emphasis on
of views that are irrelevant (or the least) and incorrect for men.

that he knows better.
this material is included. A
I

know

enclosed.

and I am at a loss to understand why
copy of my comments to him are

Since neurophysiology represents

my

principal

identification in this volume, I hesitate to recommend the
whole (since I disagree strongly with this part), lost my
approval be misinterpreted.

Alas. for the rest is well worthy of support.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>:1

inwnv-«marﬁ

1-va

“run.

r

bin-ah 15, 1970

Hr. David ﬁgyden
81310! Editor

sextant Hausa
Raw fork Clay
Ema: Mr. ﬁaydﬁn,

I have read the valunu, €2in£aal ﬁandbaok af‘Psyaho~
phanmaaalagy, adxtad by Diwunaia aaﬁ shudar, with grant interact.In samurai, tha aaaciena are well written, nuthazitativu sné typrsoant
the grcvmillng apinion a! ch: leﬁdurt xn psychaphuraaaolcuy as
unually oxyraaaed in mattingw and writinga.
r

mmwe'rm‘mw:

vv

¥her¢ is and seating. hgwavur. whiah in proacncad
to gently as to dqatwuy ch; vulva a: aha valumn for am. Enfartunately,
I tn partieulatly intcroqtﬁé in and identiftaa with neurophysiology
of psychoactivu ﬁrugg. Tbs aaatian by Miruky is too poo! to be
acccytqblc to m¢, and my gppravnl of tha rust of the Voluma
(which I mania gladly give) may ha migtakmn as my apprawal for
this cactiun as well.

‘1‘3N‘R-

Thank yam

warm-r3157,-

publieacian.

my

{at the opportunity ta cea thia

Ea»: wiuhna ﬁat

its

Vulumn

hater:

aaeoptaaes. ﬁespiae 1:9 flaw.

‘1
~

V

Kinccraly yearn,

-mvlm"éwsiwvt".=w¢

.9123

Fink, H.n.
Profaaaor at Psydhintxy

Max

W'Eemmxw

mywsm

W552“.

4-.

aura”

m

‘
1-

~mwm

mmwyﬁmrm

uf/

�</text>
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                    <text>March 14. 1970

Dr. Allen Hirsky
Boston n.1versity $chool of Medicine
Boston, Massachusetts
Hoar Allcno,

the publisher of the Clinical Eondbook of‘Pbychapharmuoology
to write a testimonial, and I was about to do so without
reading (the cxcollenco of the cast who sufficient), but was
intercoteﬂ in your chaptor. Alas. you must have doshod it of! in
your early period, for surely tho viowa are not yours today. Or,
are they 2
asked

me

The out of animal EEG data and single dosages leads to
such atntcmcoto on " Fig. 3 and Fig. 4 illustrate tho relatively
simplo affect [sic] that chlorpromnzino has on the EEG, as compared
with the variety of effects seen over time with cccobarbital”.
Chlorpromnzine is no more slmplo in its EEG affects and no dose 3
time sonaitivo as aecobarbital.
'

1..

"It is not the case, however, that there will always
EEG effects of drugs."

"."TYW‘IZ‘C'

‘4'.“

.1

"’wa'i‘i-E’“

'54.

TILL

573917

277317.13

"9

be concordancc between the behavioral and

Rotorooco to Wiklor emphasizes again tho fact that the Ems may
not ha related to motor bohavior, especially in dumb beasts. The
aissciiotion seen by Uikler and emphasized by Bradley is not the
tuna in man, for heaviors that may be relevant to psychiatry, and
this statement in a clinical volume presents the wrong vicw of

human

data.

’

‘

“

ﬁ‘Ji“

~&gt;Wm=w-;w~

"3‘93""1":

The selection of Tables 1 and 2 increases this erroneous
View. Bradley's ‘oxcited’.'drowsy' and ‘oormcl' reflect no behavioril
moosurement or tank, but simple observation of motor behavior.
Do you roally believe that 'excitod' after LSd and after atropine

are the

some [even

'f’marﬁ'

.t‘té.‘

:;'~'t:'.'v_r»

'

:-,

:.

;

.mvﬁl‘vﬂczﬂ’f‘

mammal:

;:

57'FTSITV5“;W€IE‘K:

3,12.“

.91»

hold for

Table

sumo

2

in the unspecified species deccribed'by Bradley]

is

dose dependent, and thcso

doses. but not for others.

relationships

may

1

�Mirsky

O

O

I

C

O

I

O

D

O

D

I

I

O

C

O

O

I

O

O

O

O

O

O

Page

2

There is more, but this should be enough to show where
I disagree. I horn quoted your work in animals, as you know,
as examples of what can be learned by careful EEG analyses plus caroful
and relevant behavioral measurements. How can you quote Bradley's
1957 data in 1970. after your own work 1 Or, even after our
review, that is, Bradley's and mine, of 1958 (Antioholinorgic Drugs
and Brain Functions in Animals and Man, volume 28, Progress in
Brain Roosarch,_£1oovier )

?

;

Perhaps, we should review the problem of EEG and behavior
anew. Dissociation or Association are in the eye of the beholder,
but presenting the viow of dissociation. based on animal data [without
specifying spacioo l] in a volume devoted to man (CLINICAL HANDBOOK .'.]
should be done cautiously and humbly, not carelessly, for the students
for whom.the volume is intondod, will he unablo to assess the
correctness or incorrectnoss of the text, and may be misled.
my

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

mf/

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                    <text>a

vv—w-u

«my—mum ~—- v—wpumw—ww.

V” qr... “r4m1"¢&lt;)lr'leA-'Wr.“wA w

mum.

.-

“an,“ _. .71 awn-was.

March
Mr.

w

-

N's-n-vW-‘wvv

an. 1,." w.

.

,

e

V

___...., -

an. ”a-..“ w...“ .v. w_,w .v-..,.1_-v _. a...“ ,7 .7

l3, I970

Jack Bernsteln

Boston State Hospital
Boston, Massachusetts 02l24
Dear Mr. Bernsteln:

Separately we are returnlng the sample tape. As Mr. lrwln
dlscussed wlth you. your tape recorder ls fully competable wlth
ours, except that there may be some I problem In the footage counter.
would appreclate your sendlng
To obvlate any footage dlfflculty,
a paper playback, marked In footage wlth the next tape so that
we can compare the footage meters.
A

EEG

problem ls the proper settlng of the galns of the
For those channels recorded on tape, please set the

crltlcal

machlne.

ampllfler so that

50 uv

'

l4

mm

pen

deflectlon.

suggest that as soon as you have some EEG material from
a subject on tape that you send It and the playback for us to
check agaln.
May

I

am also encloslng the output of the sectlon on zen medltatlon.
Because the sectlons are short It ls dlfflcult to Interpret. Epochs
ll-lB show llttle change from the llstlng, but epochs l9-27 may be
dlfterent,‘13g;, a decrease ln amplltude and In verlablllty, an
lncrease ln average frequency and ln fast frequencles, wlth a
decrease ln delta.
I

Slncerely yours.
may

.

w...

":41"

own-WW}

w-rmqvwv

s-

1v‘-Inr‘

Max

Flnk,

M.D.

Professor of Psychlatry
Mszp

Wmv

V

,

,,

,

�</text>
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                    <text>March [3, |97O

Dr. 0. Vlnar

Psychlafrlc Research Insflfufe
Prague 8 Bohnlca
Czechoslovakia
—

Dear Oldrlch,

Enclosed ts an absfracf from Brs. Friedhoff and Schwelfzer.
I
am also enclosing an absfracf from Professor Renner?
which I recalved foday. This absfracf does no? seem appitcable
to +he symposium on halluctnogens and I am sending If on +0 you

for procasstng.

S!ncere|y yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF3kp

�</text>
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                    <text>March 12, 1970

Honorable Lester Wolff

House of Representativun
156A Main

Street

Fort Washington,

New

York

Dear Mr. wolff:

Separately I havc tent you a packagn of material describing
work
in opiate dependence and marijuana, in conjunction
our
with my request that H.R. 13743 not be approved in its proscnt
form. As an example of the impact of Federal Laws on research,
I am enclosing a copy of a two pogo letter which I have just
received from NINE in response to my requeot for an additional
supply of marijuana to continue our research program.

While none of the requirements are difficult to meat,
each onc has an inhibiting influence. Even NINE has the
misfortune of appointing administrators of limited capacity.
Thank you

for your interest.
Sincorcly yours,
Max

Fink,

M.D.

Protozoa: of Psychiatry

�</text>
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                    <text>Maren 12, 1970
Dr. Nathan 3. Kline
Rockland State Eospital
Orangaburg, Raw York
Dear Hate,
The

rules of the

ACRP

are probably too

I have already agreed to sponsor one of Dr.

strict, for

Itil's

co~

workers for this year. I think that Br. Schulta should
be a member and will be glad to second his nomination if

I had tnother vote.

Sincerely yours,

Professor of ?sydhiatry
Hszp

�</text>
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                    <text>March 12, 1970
Dear Bob,

It

last wrote. The
studies are still exciting papular interest, with many reprint
has bean sumo weeks since you

requests continuing to coma in. There are also kooky
some of which I have sent on to Mickey.

letters,

I am enclosing Carl Ffoiffer's lotto: to you-» he aunt
it to the Biological Psychiatry, but it is meant for both of you.
As he in an oxpotioncod investigator with an extensive exporieoco
in schizophrenia, I enjoyoé his report ané on sure you will also.
you

Surely, this work should be continued, and I hope that

will plan to continue as soon as this chore in over.

Will you be able to come to San Pranoioco ? If so, the
Biological Psychiatry meetings are May 8~10 at the San Francisco
Hilton. I hope that you will be able to join us for dinnod sumo

evening.

.

.

Stanley has some of your work dooen- I asked in response
to Mickey a request, but it is unclear what has to be done next.
I suggested you or Mickey write directly to him. ané I am sure

he

will answer.

_

There is much that is going on here~- tho College is
increasing the paoo of its discussions of the move to Westcheoter;
our affiliation with Kirby Hospital (1/3 Manhattan 3toto) has
progressed to the joint appointmont of the new director (a former
student of mtno, Mort Woohoproao); and our contract for studies
in Athens has boon approved.
Stay out of miaohiof.

Sincerely yours,'

�</text>
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                    <text>March 12, 1970

Dr. Svetislav Vonov. 3.9.

Upjohn Company
Kalamazoo, Michigan
Dear Dr. Vanov,

Both the afternoons of April 20 or 21 are {too for
your visit to those laboratories to discuss U~28,774. I look forward
to roodiug the material that you have sent. and ohould be able to
provido a protocol to mac: your toquironontu.

Please call my office
confirm the date best for you.
Room

62.

The

office is at

S

(212—369 7900, x246,248)

to

East 102 Stroot, 8th floor,

Sincerely yours,
Max

fink,

M.D.

Profoasor of Psychiatry

m?!

»

_

'_

y‘nrnmhuyg-zmww:

W3V'

”TIEY’I‘".

�</text>
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                  <elementText elementTextId="105830">
                    <text>March 12, 1970
Dear Mickey,

reprints,

Your
Some

sent to you).

nail continuaa ta
are ’crank'

cone 1n«~ moot requests are

letters, and some ara interesting

for

(and

The latest inane cf 81olag1cal Psychiatry has Carl
Ffeiffer’a response to your work, and his supvort is intaraating. He
is a very kuowledgable yharmacologist and has extensive experience.
313 snggast1ons are good as thay reflect the reapense of the

'establishmant' to your work.

I,

and a {aw 02 tha

staff, plan to

be in San Franciscc

far the B1elogical. Panchiatry Inﬂ APA.meet1ngs. Try to get a few
dawn off and 1010 the meetingo~~ ﬂay 8~10 for EioPsvch (E11ton
Hotel) and 1.135 £0: A?A.

,

’w-Wﬁ-rhu

;
"Nu-gm:

As for our untk—~ nothing new on lactate; I have given
to stanlay and get an amtiguous response (Write to
message
yaur
him diractly and his cultural heritage will elicit an answer [his
wife wag just delivered of a fine seal); and Dick aaams to hava been

unable to negotiate the member system to taut the penicillamine
hypothea1s. But he is busv u1th othar t111ngs, including a fine

theory.1ar the testing of an antagonist to alcoholism; and his
is progressing well, albeit slowly. Ha took his fitst spinal
fluid sample today and is on h1a way to test thc cutacholamine
and acetylcheline hypotheses of ECT.
ECT

The.achool is planning to push its move ta Westchescet
rapidly;-ve have just appointed the new superintendent of the
Kirby Boapital (1/3 Manhattan State) to an: ataff; our aontract
for a study in Athens has been approvad (marijuana, of coursa); and
lots more. It W111 keep until May. Plan to have dinner with us.
Keep up

the good work.

Sincarely,

�</text>
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                    <text>,_.,_.V,~,

A-

~.~

'tw-M'nw'r"

w-

March 11, 1970

on”

.43.

—

.m~.M-u,.*..a

51.5.,“

‘

Dr. Sholdon Gaylin
Depateucnt of Payohiotry

Grasslands anspital
Valhalla. How York

~J....,,._.V.v

Door Sheldon,

It

was kind of you

to

to amok time with no_
toﬁny. I was inorouaod with orogtaou that has boon made in tho
psychiatric facility, tor when I left tho hospital two yoato ago
after a oimilar visit, I was doprenood about the Collage moving
soond

to Hostchostor, but I fuel vary differently today.

trust that

I look forward to our continued collaboration and
some studios may ho dovolopod in Grasslaoau to augment

the ongoing program».

Stocorely yours,
Fink, M.n.
Professor of Psychiatry

Max
a!"

w":

.

,
"

"WI:

7

“a

“afar-.-

2-

31'

H

U

..

:n.-.:4.‘-:e';v,aw

v.

.-

49:13:74»,

.4

17,0]."Zl

,.

mf/

�</text>
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                    <text>March

l0, l970

Dr. William Tabor

A. H. Robins Company
i407 Cummings Drivo

Richmond, Virginia
Dear

Bill,

A review of our AHR~|900 laborafory data for changes in
blood glucose suggesfs fhal a hypoglycemic effect may occur
in some subjects, but our data is unimprossive. An absfracl
of fhis dafa is enclosed.

Blood glucose (88) measures during AHR~i900 and placebo

periods are available for

6

subjecis recaivlng

AHR~l900 in

400 mg. in L.F., J.M., A.G., and J.V., blood
dosages
in one measure each than during lho placebo
lower
glucose is
and
D.K.
in
period;
0.5., blood glucose remains of the some
in
blood
level.
L.E..
glucose is low bu? no preudrug oonlroi
AHR*l900 for 9 days only and The
received
is available. J.L.
no?
88
is
value
consfrucfive. Subjocf M.D. did not
single
have leafs while on N4R—l900 and R.L. and E.H. received placebo
only. When i asked Dr. Jones, our lnlernisl, she reiafed The
low 86 readings in 3 of The palienis lo dosages of l20 mg or
more of AHR-IQOO.
up To

available for shipmenl, as
ind
for
final
is our roporl, excopl
analyses from The Siomofric
To
do
awai?
these
complale fhe publicalion reporl.
Loborafory.
The ofher data on NlR~i9OO is

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mkap
911C

.

�</text>
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                    <text>March

l0, l9?!)

Dr. 0. Vlnar
Psych lafrlc Rcsoarch l ns‘ll ‘lu‘l’c
Prague 8 ~ Hohnlco

Czuchoslovakla
Dear Oldrlch,

l.

.Smposlum

paml for

ﬂu

I? has bwn dll‘flcul'l' fo assemble a sulfabla
symposlum on amphetamlm and halluclnogen abuse,

bu? l bellcw +ho aﬁached outline
look ln a few weeks. 2'53“ to
_2m

ls The way #ho program wlll
stilt provisional and {a not to

winked.

for flu publlcaflon of absfracl's, you may use ﬁlls
We
oul'llns for
panel, and as The formal abstracls arrlvo, l wlll
‘l'hom
sand
pow-hash 'l’o ym. lf may arrlvo ln flm. they should
be publlshed as wall; lf not ‘l'ho wawlow should do.
To allow

1’0 your earl lor suggesﬂon of a report on
abuse
by Angrls‘l‘ and Gershon, l have dlscussed ‘H’lIS
whommo
wl'lh Prcfonor Frladhofl, and Ms presanfa'rlon, whlch l prefer,
ulll cover such of fhls matorlal. The Angrlsf-Garshon report
may be lncludod la ﬂu fr» mulca‘l'lons.

ﬁlth referent»

2. Travel funds .
I

shall

la‘rfor (2/0/10) -

usoyup f0 $l.000.00 as suggoshd In your

I”: ll

ponlblo.

�«2-

Dr. Vinar

3.

Prqgram Cnumltfoo

March

l0,

W70

nofosll2/25/70).

Co~symposlaz

A

useful

mama,

principal of chairing these prosonfuflons.

and l agrao with the
The spocial IosSIOﬂs:

For elecfrophyslclagy: llll as co~chalrman; if you wish on
animal nauraphysloloaisf as ca~chairman, I would sugges? Dr. Hilfon
Klefzkln (Hallaca Labaraforlos. Crunbury. Hun Jarsoy 085l2).

Far clinical frials, Ennis or a reprasaniallvo of The Germanw
Swiss unifs should be considcrnd.
For

prediction, perhaps

van would wish sdmeone who uses

physiological predictors, as C. Shagass (Tampio Unlvorslfy) or

H. Eysenck (Mandalay).

For panolrallon 0i drugs in inn brain, Dr. John Rach (Oarfmoufh
College) or Steven Sharwood (Sfanfard Universliy).
As for llmillng prasantalians,
aufhor.
par

4.

You

ara dalng a fine Job.

its? of formal

sympcalum

i

in

would agree

Keap

l? upi

participants shoriiy.

i

will send 1h.

Sincaraly yours,
tam F‘nk’ M09.

Professor of Psychlafry

Mszp

cc: P. Kloiholz

ona prasenfailon

�</text>
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                    <text>March

i0, l970

Dr. P. Kleiholz

Psychiairlsche Unlvsrsifniskllnik Basel

Wilhelm-Kisin-Sfrasso 27
4056 Basel, Swifzoriand
Dear Dr. Kielholz:
Some

offend.

i

of the

earlier suggesfed parflclpanfs

have sea?

The second round of

were unable +0

invifafldns.

Dr. John Griffifh accspfs, he will presen? his data on
amphefamlne abuse in The U.S. Your observafions, on drug abuse
in EurOpe, should be a logical accompaniment of this dais. either
as discussion or as a confrssllng (parallel?) reporl. Would you
please send me a fills and a lOO-iSO word abstracf, as soon as

if

pracflcabie?
As

soon as the various

immediafsiy.

invitees

have agread,

i

will write

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychialry
Mszp
one .

�</text>
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              <elementText elementTextId="42693">
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                    <text>W.

l0,

March

l970

Dr. John R. Smyfhles
Depatfmonf of Psychiatry

Unlverslfy of Edinburgh
Edinburgh l0, Scofland
Dear Dr. Smyfhlas:

have been commissioned by rho Program Commiffee of fhe
ClNP lo esfablish a panel on ”Pharmacological and Therapouflc
Aspects of Amphetamine and Hallucinogen Abuso” a? i The iorfhwould like
coming mooring in Prague - Angus? ll~l5, l970.
to focus fils program on The biochemical and pharmacological
aspocfs of amphetamine use and have asked Drs. Friedhoff,
l
have read
To parTlcipafe.
Griffith, Kielholz and Oswald
NRP
”Mode
of Acllon of
session on
your recon? summary of The
i
Psychofomimoflc Drugs“ and would like To invifo your parflcipaflon
in This CINP Symposium, asking That you summarize The NRP views
(porllcularly your own), as exempllflod by rho data on
amphofamlnes. The symposium will fake place befwoon Augusf ll-IS,
and i would allow 20—25 minutes for your preseniallon.
l

but

i

The ClNP does no? ordinarily provide funds for These meofings,
have been given a limited budgaf and i would propose to

divide if
As

i

have been delayed in puffing fogofher

and am abouf To be

absfracf (l50~200
Many

parllclpanfs according to need.

among The

chasiised,

words) by

Thanks and

l

may

air

i

this panel

ask that you sand

mail special

delivery.

hops That you will bo able To

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
HF:kp

me

an

parflcipafe.

�</text>
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                    <text>13

--

«www- WWI-v“ mmvmh’cv

-

n—W—W w

»

.~—.

'WW... ._,.... _. m’-..‘

"""m"""“""!

‘

March

i0, i970

Dr. John Griffith
Department of Psychiatry

Vanderbilt University

Nashville, Tennessee
Dear Dr.

37203

Griffith:

i am pleased to invite your participation in a symposium
on "Pharmacological and Therapeutic Aspects of Amphetamine and
Hallucinogen Abuse“, at the forthcoming meeting of the GIMP in
Prague, during the period August li—l5, l970. We would like to
focus on a review of sociopsychiatric, biochomlcal and CNS
aspects of amphetamine abuse.

The emphasis is on ”abuse" tolerance and dependence, rather
than amphetamines as a model for schizophronia.

would like to ask you to prasent an overview of amphetamine
other sympathomimetic abuse in the United States, as wall as
your studies on the behavioral effects of amphetamine use. The
invited participants are listed in the enclosed abstract.
i

and

For your

if

you

presentation

you should allow 20—25

are able to participate,

i

minutes.

should be grateful for

return mail.
title
(l have delayed overly long in putting togothor this panel and

a
i

short abstract

(i50«ZOO words) by

about to be chastised.)

am

will

and a

Details of the meeting, as to hotels, location, gtgl.
return mail.

come by

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

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                    <text>March 1. 1970

Dr. Ivan R. Reilaen, Ph. D.

Loma

Linda ﬁniversity

California

Dear Dr.

9235a

ﬁeilsen,
Thank you

for your inquiry abaut our

EEG

analygﬂa

taking the liberty of enclosing a copy of tha
letter I wrote today in answer to a similar inquiry, and trust
it will answer your initial questions.

syntam. I

am

If there are specific problems that you face in
the application$ at yaur canter, we wvuld be pleaseé t9 try to
£3313! in any practicabla way.
Sincerely yours,

Fink, H.D.
Professor of Paychiatry

Max

mf/

�</text>
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                    <text>Hatch 10, 1970
Dr. Turan

M.

1:11

Missouri Institute of Psychiatry
5400 Arnonal

Street

St. Louis, Missouri 63139

Dear Turan,

have never receivad reprints of the trifluperidol
paper. These are the only two requests I have received.
Would you care to answer these and perhaps send us a few?
Wu

Also,

this is the only sleep classification reprint

raquoat.thnt I have not answered.

Sincerely yours,
Max

Yink, M.D.

Professor of Psychiatry

Hszp

7A.“.

A};

A

‘

‘

‘\

‘

‘

'

�</text>
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                    <text>March 9, 1970

Dr. Alice A. Lead:
Chief International Belerence Center

for Information

on

Psychotropic Drugs

Psychophermacology Research Branch
National Institute of Neural Health
5654 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Alice,

Following your suggeetion, Dr. Shapiro and I have edited
of our program review for the "Paychepharaecology
Bulletin”, and we trust it meets your standards. We would be
pleased to have the summary included in a review of ongoing
psychaphermagology programs.

the

summary

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 9, 19l0

Dr. Joan Giambalvo
Smith, Kline &amp; French Laboratories
Philadelphia, Pa.
Dear Dr. Giambnlvo,

I have just read the latest newsletter of the BIA,
and noted the call for papers for the Septenbar meeting. I am
not sure that the work which we are now completing is of airect
may be useful for you to
interest to the Association, but

it

profile analysis of psychoactive drugs as a
classification procedure. As'you may recollect, we have been
active in defining drug specific EEG patterns in patients and in
normal valunteers, in an effort ta defina tha characteristics of
haw comrounds before thay have gone through artensiva and extensive
clinical trials. Tha work has had some interasting results. notably
in the classification of cyclazocine as an antidepressant, doxepin
as an antidepreasant, fantluraminc as a reﬁttiva anorexigenic, etc.
If there is a panel or symposium dedicated to novul
consider the

EEG

methods of assay of paychoactiva drugs;

or, with an emphasis on
the types of naval data nalyaen that may be useful in tha next
few years for psychopharamcology, perhaya you «bald consider

3

of

presentation by my associates and myself. on the general topic
“EEG Profile Analysis as a classification of Psychoactive Drugs".
Thank you

for your consideration.
Sincarely yours.
Max

rink,

H49.

Prcfaasor of Psychiatry

Mf/

�</text>
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              <elementText elementTextId="42753">
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                  <elementText elementTextId="105835">
                    <text>-.

-

,V,-

m

”mi—Viv”,

w.

Mltch 8, 1970
Dear Jon,

Yoatotduy. I met woth my local Congressman, Lasts:
Woiit, and discussed the Kongo bill transferring control of
rasoareh to the Justice Department. He was most oympathotic
and askod if the boat approach might not be to hold hoarings in
Raw York. on the basis of tho bill, to describe the present
efforto in drug reaoaroh.
This may have been a

'put~off'. but

he seemed

sincere

(are thoy not alwaya ?) and askod that I lend him some additional
data. I left the tootimony you gave mecwith him, and promised
to send additional.

material

list

Plooae add his name to the mailing

on the

bill:

of any direct

Hr. Lester Wolff, Coagrosnnln
156A Kain

Street

Port whohingtoo,
Many

Now

York

thanks.
Sincerely yours,
Max

P.5. I look forward to seoing you in

Fink,

ﬂow York

M.D.

Friday.

�</text>
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                <text>Correspondence to: Cole, Jonathan O.</text>
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            <name>Date</name>
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                <text>1970 </text>
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            <name>Creator</name>
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              <elementText elementTextId="42758">
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            <name>Relation</name>
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            <elementTextContainer>
              <elementText elementTextId="42762">
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            <name>Source</name>
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              <elementText elementTextId="42763">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            </elementTextContainer>
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        <name>Correspondence</name>
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    <fileContainer>
      <file fileId="2639">
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                    <text>.

-.

n

p

,,.A,

‘7.‘.V‘.__....'.

"WWW-w

wr

“"me m..- «;“...._—..¢r.*-i.-~‘

"WVY~‘-1Wu-.~“n~‘ wuv

v.»

“:7

v

--~

....

ur-

~-—-w---—-—v—~v-/

-

-*—" '«

WW &gt;-

-

«~-

"~—-“ --‘

-

W‘WWﬂ/A

1--mwv~un&lt;mm

r
w

“.mw-

.3,"

'l'iih'Iv-Emrn.

r-n—

”arch 8, 1970

—£rFY'-4WW.

Muy

mung—raw

"vi.

Honorabla Lancer Wolff

Henna of Representatives
156A ﬁnin

Street

Port ﬂashington.

New

York

w-

V.”

us
v-

Bear Mr. whiff,

It

was kind of van to listen to my presentatian
regarding ER~137é3, now before the Public Health &amp; Walfara
Committee.

It

my experienca that our prasent laws and
police nuthoritigs havg inhibited zesaarch,
both in epiat¢s &amp;nd cannabis, and aontributaé matarially to our
preoant confusions and hysteria. Our labcratories, at the New

has baan

that: execution

by

York ﬁedical College, are davateé to obtaining some of the needed
informatien. Sons of the results are already publiohod; others
are preliminary; and other: are in the planning stagcs. I am
enclosing some matarial from our files that may he 0: interest.

y.»

am

»

-..

"WWI-mm

vu-

The

is

suggestion of holéing lagiatacivn hearinga in

a good suggestion, and I would be pleuaad to converata.
I an.cncloaing a list of suggestad witneaae; who would bu
scientifically. and perhnpa* politically interesting. With proper
preparation, tha quaationn of the effect. of tha law on therapy
and on research may bu elaborateé.
new Ybrk

Again,

my

thanks far your patience.

Sincerely youra,
ﬂax Fink, M.D.
Frofaasor a? Paychiatry

4

.

7-"lF'

«run—g

'1
.
.\

w&lt;-:~'?JY«;-—:

z-m—n

”warm-4'1.

..

'nm

mf/

�APPENDIX

Enclosed Documonts

I

Opiates and Antogoniata

l.

A

Program to
1970.

Restrict Opiate
Dated 2/3/70.

Dopondonca~rhe Urban Epidemic of

2. Antagonists in the Treatment of Opiate Dopondonce, 1969.
3. Intravenous Discotylmorphine (Heroin) in the Stndtlont of

Opiate Dependence.

1969.

6.
4. Basic Concepts and Use of Cyclazocino in the Treatment of

Narcotic Addiction, 1968.

5. Naloxono in Heroin Bopendeoco. 1968.

é. Cyalazoeine and Methadone in ﬂarcotic Addiction, 1967.
7. A Proposal for the Development of Long Acting Opiate Antagoniats,
1969.

v.
7:.

'rvv.-'¢

.aswn

-

V,....

.,,,

w'uﬁmemig.prx;‘V_—vku'wr.rw

Marijuana
8. Forspectives on Marijuana Research. 1968.
9. Preposal. Clinical Phatlnnology of Canoabio, 1969.
and Behabiorol Effects of Long Term Cannabis UseFoasibility Study, 1969.

10. Proposal,
A

‘ﬂ‘irre'wr:

‘Iltl‘lfﬁ'hz’wv

1:1"!

or

EEG

Poraonnol
11. Curriculum

vitae,

Max

Fink, H.D., Professor of Psychiatry

,ms'."

1:1".

I.’

Froedman, H.D., Professor of
Psychiatry anﬁ Chairman, Department of Psychiatry.

12. Curriculum

m",-

vitae, Alfred

mm".

List of Proposed Witneoses

APPENDIX 11
.f‘wiﬂv-

New
N'wwmrvz':

York Medical College

Alfred

3-”

Fink, M.D.
Arthur Zako, M.D.

"lﬂi’W-‘Iﬂ°£w*ﬁui-

New

York

State

'7.

m“:,‘fi‘i‘vv"

,
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Froedman, H.D.

Max

1:19.,

so“

M.

Richard Brooms“, Fh. D.

my

”I

M.

Max

Singer, Hudson Institute

Vincont Dole, Rockofollor University

Brill, Pilgrim Stats ﬁosoital
Christopher Torrance, 8Y8 Narcotic Addiction Control

Henry

Comm.

�</text>
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                    <text>.

.

.u—

.

.

W,qrvuwmm

-v.-...,—n.

m‘:».‘rw .7.

,_ ., "Iaw-xw...u-r. 710-1.. ,, __‘3‘...._ “WVM“"m ~‘

--.-. 7‘ .n-w
...—.....(...-. ’.\w|»§l'l

:w

7-

w'vr-v

Yr .m- mmw

.

W..Mw~..—-v».n,w:«u-r

'lwv.

‘

:1

-

March 8, 1970

Dear Dr. Gaberg,
and I

Please call
will arrange to

through our program.

office on your arrival (212w369 7900)
have somecnu frcm hbe staff escort yau
my

You may be interested in the presentation by members
.of our department Thursday evening, March 12
at Gracia Square
Hospital (420 East 76 Street) at 8 p.m. A visit there may give

you an overview of the program and a progruas report on our present

arperitnces.

'

Sincerely yours,
Max

Fink, M.D.

Profeauor of Esychiatty
mf/

awn-w

.
w»

lwvvgﬁ‘w‘

.w-m

mm”,

�</text>
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                    <text>March 7, 1970

near Irene,
Thank you for the inquiry about a coufaronce on
phenothiazines. As you know, my primary interest is in the I have
neurophysiology of compounds, and not their chemistry, so
not had much of direct interest to contributa.to anrliar conferences.

be hald, preferably in
ﬁeverthelaaa, I think such a confarencu should where
much of the
England
1971 (late), in Europe, preferably in
work seems to be progressing rapidly.
An is generally experioncad in many confarenccs, a
amall mnetjng of £O—60 participants and an additional 30~50
observers 333mg to he the most useful.
The theme of the meeting shoulﬁ deciée on the participants,
and suraly the lander: of tha last nesting may ha the best to
assess the relevant interesting tapicn.
My

best regards.
Sincerely years,
Max

Fink, M.D.

Professor af Psychiatry

mf/

�</text>
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                    <text>‘-

mw-wmn-vu

:—

1,:—-.m-

«r»

n;

:45»;

:er

m.

-'V""P‘u'&lt;1"nz"ymu

Hr. Ha: Singar

March 7, 1970

Hudscn Institute
Cratenmen-Hudson, ﬂew York

Dear Mr. Singer,

I hnva read your interim report and apttndices with
interest, particularly since tha viawa are both novel and
engaging. A heroin diﬁttibution system, if faaaibla, may indeed
be a useful interim step in reducing the opiata abuae probleg.
An immediate reaction is raferanta to tha reputed failura of the
Britiih system, and your teviaw of that 'failure' is too superficial
to be convincing. I 3139 believe that our present climate will
not allaw such a system unlass it is encumbered by psychotherapy,
social tharapy, rehabilitatian, gtuup therapy. ggg,~ and this will
increase the costs markedly. Is this not nae of the handicaps of
the ﬂaw York State system, that it pays lip setvica to all systems.
much

having none

at its can i

I wauld immediately agree that tha heroin addiction
ptoblem~is not purely a medical problem, and that the solution
is not purely a madical oat. But that was also the status of the
syphilis, the tuberculasia and the leprosy problems. before medical
sclutiona wart definad. These medical solutions plus tha social
has had tht major impact in raducing the tragedies of these, now
curable, diaeaaea.

Since discussing our praposal for unloxona with you, we
have reviewei tha cyclazocint data, and find that the same approach
is feaaible for this drug as wall~~ that increasing the costs of
our proposal, since two drugs ought-to be studied. We are not
optimistic that either the ﬂaw York State nor the National Institute
of Mental Eaalth will provide fundu~~ both have said all the nice

things like the idea is excellent and tha awed is great. BUT . . .
differ in their ”BUT’S"? the results will be the same. we have
aleo made a presentation to the lawyers cf the Vera Institute, who
alao spoke highly at the ideas but "BUT«TED” the possibility of
They

tunding away.

�Max

Singer

0..HOODGIO.QiﬁtboblotOO‘OIOOIOOIOOOUOOMarch 7, 1970

principal question of your letter relates to the
of
channeling
opiate users to other substances if a concerted
governmental action inhibits the use of heroin. Indeed, that is
likely. Let us suppose that the heroin (opiate) use is severely
inhibited, and marijuana use increases markedly. So long as the
penalties for marijuana uoe remain the same, the results iutterms
of crime will be the same. But is it necessary to maintain the
fiction that marijuana in as deleterious as opiates ? I have
worked with both types of substances, and have read the literature
carefully. There is no relation in pharmacology or physiology
between the substances. One is Beverly toxic to the body, causing
extensive chemical chengeo that persist for weeks, months and
perhaps years; the other, minimal changes, of a transient nature.
Deaths do not occur with cannabis; they do with opiates. That is a
sufficient basis for me to consider the channeling of opiate users
to marijuana to be a social good, not evil, in the present climate
(provided the penalties were removed for marijuana use).
The

for the ’soft~drugs‘, here too, the pharmacology and
of
physiology
methedrine, amphetamine and the barbiturates are
sufficiently unique that the distinction from ooiatee is easy.
Addiction may occur, but deaths are lose common; dosages necessary
are very large for fatality; and while I am not so enthusiastic
about channeling to these drugs from opiates, I consider them
eo much less damaging, one addiction so difficult to achieve, that
e ‘uer' on opiates with a resultant increase in the abuse of
these drugs is still a useful 'wer’. (In the balance of nature,
the abuse of these drugs seems less commonly achievable than the
abuse of alcohol, and we have been able to live with that abuse
as a nation.)
As

-

You mey be pleased to know that the National Institute
of Mantel Health has looked upon our suggestion that a team of
atientiote be sent to Greece to study chronic (20»30 year) heehieh

users with

some

favor, and called to any that that contract will
effort to obtain some

be awarded effective June 1. This will be our
data on chronic cannabis abuse (use).

for the comments, the questions, and especially
for the preliminary reports with their novel (7daring?) suggestions.
Thank you

Sincerely yours,
Fink, M.D.
Profeaoor of Psychiatry

Max

mf/

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                    <text>March 7, 1970

ﬂoat Irena,

far the inquiry about a confatence on
phanathiazinas.
you knaw. my primary interest is in the
naurophysiology of compounds, and not their chemistry, so I have
not had munh of direct intereat to contributa.to warliar conferences.
Thank you
As

Heverthaless, I think such a eonferencc should be held, preferably in
1971 (late), in Europa. preferably in England whit: much of tha
work seams to be prngzeoaing rapidly.
As

is generally expariencad iuv

many

confurences. a

small wanting o£ aowse participants and an additional 30~50
observers anew; :0 he the moat nacful.

of the m&amp;ettng shauld decide on the participants,
9f the last wanting may ha the best to
lmadara
the
suraly
the
ralavant
internating topics.
assaaa

and

The them:

My

best regards.
Sincernly yours,
Max

Pink, M.D.

Professor of Psychiatry

mil

�</text>
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                    <text>17

.
n—w,

Wm:

"er

.-.-n

wan»

.

"any“.

‘

t..-.‘-,_r.,..,....

if.

7.0

.ww,..w,_......__

__

~_m1-qu»w.—_,mn- .ﬂtwm—mwmmwwm. .d .m

-

mwwv

‘4‘W'V'~

March

.. -‘ ,, 7., ...u

6,

,

.

.

_

..-,

v

.7...

u» -

N

v

7

in

._-.

....

....- "r...

1970

Dr. G. F. Blane
Rackitt &amp; Sons
Hull , England
Dear Dr. Blane,
Tue

yanrs ago I wrctv to obtain information on

narcotic antageniats, particularly SOSO—M. it the recent
NRC meetings in Washington, a format associate, R. E. Lister,
mantioned that you had worked on a long~aeting narcatic but may
have discardad it because of its unusual length of action.
long acting narcotic with cross tolerance to opiates
useful adjunct in the treatmant of cplatm
dapendence; as would a long acting and potent narcotic antagonist.
A

would be a most

I am writing to raquast any infatuaticn that may be availahle
regarding patential human trials with either 0f these compounds.
Bava trials with 5050~M progressed to aageasments in man ? Is
there, indeed, a vary long acting analgaaic with cross toleranca
to opiates available ?

bafcre, we are actively involved in
of
these
aubstancea, and unuld appraciate the
trials
opportunity to extend theaa investigations in any masningful

human

As we wrote

way.

Thank you

far your assistance.
Sincerely yours.
Max

Pink, M.D.

Profesaor of Psychiatry

mf/

cc:

A. M. Freedman

,_

"y:-

,

.4 w

-

7-“

-.

‘

,

V...,

-

.....,

—

�</text>
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                    <text>March

Dr.

J. J.

5,

1970

Lasky

national Institutes of Mental Health
lOAlO Barlow Building
5454 Misconsin Avenue
Chevy Chase. Maryland
Dear Jack.
I am pleased to enclose five copies of the report
"Lateralized EEG Changes after Unilateral and Bilateral
Electroconvulsive Therapy", as requested. In addition I
am also enclosing a preprint of a manual of convulsive
therapy which we have submitted to the APA for publication.
In presenting the principles of this treatment to our
residents, we found the usual texts to be incomplete and
we wrote this document as a teaching device.
My

best regards.
Sincerely yours,
Max

Fink, M.0.

Professor of Psychiatry

MF:kp
ENC.

�</text>
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/~un

Wmav

Wad

March

5, 1970

Dr. Phillip Tannenbaum
Smith Klina and French Laboratories
lSOO Spring Garden Street

Philadelphia, Pennsylvania
Dear

Phil,

Enclosed are copies of the screening interview forms
subject permit used in our laboratory. I propose to
in the doxepin study.
these
use
and the

In addition copies of the other forms are enclosed

ymwianmﬂmn
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
811C.

for

�</text>
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                    <text>March

5,

1970

ﬁr. Anthony Kales
Department of Psychiatry
University of California Medical Center
Los Angeles.

California

90024

Bear Tony.
1 have just returned from California and in checking my
notes find that I had promised to send you the enclosed information
with regard to our experience with doxepin.

I am also enclosing a sample protocol and interim report
of a compound which is now undergoing study. This information is.
of course, preliminary and I trust will be verified in the ongoing
study.
Come

visit

us when you are in new Yorkk

Sincerely yours,
Fink, M.D.
Professor of Fsychiatry

Max

MF:kp

�</text>
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                    <text>March

5, l970

5. Bureau of narcotics and Dangerous Drugs
l405 I Street. n.n.
Washington, 8.6. 20530
U.

Attention:

John Mayer

Bear Sir:

M

'
J14

I am writing to request 5 grams of recrystalized purified
heroin to continue our studies.

did receive l0 grams in Qctobor l969, but recently
we noted that the remaining supply has an acetic odor and has
become slightly yellowish. In checking old pharmacy books, we
find this to be a sign of deterioration which is ordinarily
prevented by keeping the supplies closely sealed and in the
dark. I regret that our supply has deteriorated. If purified
heroin is available at the Bureau. we would be grateful for
5 grams and will return our present supply for rocrystalization.
we

Thank you

for your cooperation.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

:4
at
.31..

.
)..ae_

1“

�</text>
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                    <text>March

5,

1970

Dr. Anthony Kales

Department of Psychiatry

University of California Medical Center

Los Angeles,

California

90024

Dear Tony,
I

have

just returned

from

California

and in checking

my

notes find that I had promised to send you the enclosed information
with regard to our experience with doxepin.
I am also enclosing a sample protocol and interim report
of a compound which is now undergoing study. This information is,
of course. preliminary and I trust will be verified in the ongoing
study.
Come

visit

us when you are in

New

Yorki

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 4, 1970

Dr. Alexander 6. Karczmar
Professor and Chairman
Department of Pharmacology and Therapeutics
Loyola University, Stritch School of %odicine

Chicago,

Illinois

Dear Alex,

to

Enclosed

NIMH.

is

a capy

of the supplement application

Dr. Abrams is looktig for a suitable
touch with you as soon as he finds one.

subject

and he

Sincerely yours,
Max

Pink, M.E.

Frofessor of Psychiatry

MF:kp
BBC .

as we submitted

will

be

in

�</text>
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                    <text>March

4.

1970

Br. Turan M. Itii
Missouri Institute of Psychiatry
5400 Arsenal Street

St. Louis, ﬁissouri

63139

Dear Turan,

Separately I am tending you fifty reprints each of the
cycioserine and oyciazocine papers - just to prove that I
am

still

working for you.

There are an additional

whose address I do not have.
My

set of reprints for

Dr. Ponce.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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              <elementText elementTextId="42892">
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                  <elementText elementTextId="103270">
                    <text>March

Dr. Ivan Bennett
Ely Lilly Company

Indianapolis, Indiana

4,

1970

46206

Dear Ivan,
I am pleased to enclose a copy of the report ”d~Cycloserine
Therapy of Psychosis by Symptom Provocation", which resultad

studies in Missouri.
application has merit.

from the
ﬂy

As

you can

tell,

we

think that this

best regards.
Sincerely yours,
Fink, .M.D.
Professor of Psychiatry

Max

Mszp
ENC .

�</text>
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                    <text>March

4, 1970

Dr. Lewis L. Levy
290 Meeting House Lane

Orange. Connecticut
Bear Lew,

After many years. the report on cycloserine has finally
appeared in press. I am pleased to enclose a copy. We found
this application in exacerbating schizophrenic behavior very

useful.

Since leaving Missouri, I no longer have chronic
schizophrenic pat ants and have no longer continued this
line of work.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

enc.

�</text>
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                    <text>”mu—Vw...”

March

4.

7 7,.

n

1970

Dr. Joseph C. Bird

Director of Expnrimenta1 Medicino
Ster1ing~winthrop Research Institute
90 Park Avnnue
new York, new York 10016

Dear

Joe,

to enciose two reprints of our paper “Ciinical
Antidepressant Activity of Cyciazocine - A Narcotic Antagonist“.
I am p1ensed

We

Stu dy.
Has

are gratefu1 for your support and encouragement in this
there been any progress

on a 1ong

cyc1azocine?
My

acting formu1ation for

best regards.

Sincere” yours ,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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              <elementText elementTextId="42922">
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                <name>Text</name>
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                <elementTextContainer>
                  <elementText elementTextId="105844">
                    <text>rum—~—

r

w“,-

..;,

.-

-aw.—¢_-m-v.v-..

..—,

“new.”

..u ..

.

\

.

,.

.

r.

Y

a

1

A“.

«a; ”we‘d";

e

. m «WW7 -~ 7“.“ Twp“ rr‘ .

March

vim-“w.“ ".~_,-

m.

"w “WW..-

7,

v.

m u—w-n w “WWW—var... “We...

4, l970

Dr. Charles Shagass

Eastern Pennsylvania Psychiatric Institute
Henry Ave. s Abbottsford Road

Philadelphia, Pennsylvania l9129
Dear

Charlie.
A

copy of the

distributed at the

list

members nominated for the APPA as
meeting is attached. To the extent possible.

of

would you please have your secretary give us the addresses of
these candidates? Hould you formulate an appropriate letter or
would you trust us to do so?

If

we

My

best regards.

be glad

have the addresses and the proposed

to send out the invitations.

Sincerely yours,

‘

Fink,
Secretary

Max

;

MF:kp

enc.

M.D.

letter,

we

will

. on

in...

«"mu".

�</text>
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                    <text>harch 4, 1970
Mr. Edward Aifeno

*

Import Spocieiist

Custom House
Bowiing Green,
’

New

York 10014

Dear Mr. Aifano:

Foilowing our discussions I am enciosing the ye110w copy
of permit #2429, dated May 5, 1969. ﬁn May 16, 1969, I returned
to the United States from Athens, Greece. I brought with me

heshish, which I obtained from Professor
was inspected
J. iiiras, University of Athens. The materiai made
on the back
and
notation
a
Internatione1
Airport
at Kennedy
1
additiona1
an
had
receiving
anticipated
of the green copy.
supp1y of THC-A-9 and kept the permit in my possession. This
supp1y was not sent nor have I received it. Unfortunateiy,
neither my secretary nor I can recoii the fate of the green
copy. we do not anticipate importing under this certificate
any additiona] suppiies.

250 Grams powdered
{3.

The materie1 brought in 1est Hey, 1ess some

a1ready used in our

et

5

that

East 102nd Street.

Thank you

for your cooperation.
Sincere1y yours.

Fink. M.D.
Professor of Psychiatry

Mex

Hszp
811C 0

we have

studies, is in our controi in the 1aboratory

�</text>
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                    <text>March

4,

1970

Dr. M. Keup
581 Ciarkson Avenue
Brooklyn, New York 11203
Dear

8r.

Keup:

Enclosed is an abstract for your consideration for the
first Muitistato Interhospitai Conforonce of EPRA. Dr. Abrams

wiii present this report. If it is at all possible, he would
appreciate a presentation on Friday since he has a prior
commitment on Saturday.
My

best regards.
Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬁszp
ehc.

�</text>
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                    <text>‘

March 4, 1970
Mr. Herb

Sturz

Institute

Vera

30 East 39th

New

York,

New

Street
York

Dear Mr. Sturz:

Enclosed is a draft proposal dated November 27, 1969, which
describes our suggestion to the National Institutes of Mental Health
and to the New York State Narcotic Addiction Control Commission for
the development of a long acting narcotic antagonist.
Since formulating the proposal we have had additional experience
with cyclazocine which makes us believe that the same principles and
techniques should be applied to the development of a long acting
form for cyclazocine as well.
For either naloxone or cyclazocine, the first step is the
development of a slow release form and a determination of a maximum
amount

that

can be concentrated in a

silastic vehicle.

The

initial

animal trials must be undertaken to determine the release rate.
These pharmacological aSSays can be done by a number of American
consulting firms. If this formulation is successful, then concurrent
animal and human trials must be undertaken in the animals for toxicity
purposes and in humans fer toxicity and the determination of the
duration of antagonism.

requested are for the pharmacological feasibility
such actions appear logical to you and your committee,
associates and I would be pleased to cooperate in any way possible.

only.
my

The fUnds

If

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
enc.

�</text>
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                    <text>March

4,

1970

Dr. N. Keop
681 Ciarkson Avenue
Brooklyn, New York 11203
Dear Dr. Keup:

Enciosed is an abstract for your consideration for the
first Muitistate Interhospitai Conference of EPRA. Dr. Abrams

will present this report. If it is at ali possible. he would
appreciate a presentation on Friday since he has a prior
commitment on Saturday.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

enc.

�</text>
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                    <text>March

4.

1970

Dr. Lewis L. Levy
290 Meeting House Lane

Orange. Connecticut
Dear Lew,

After many years, the report on cycloserine has finally
appeared in press. I am pleased to enclose a copy. We found
this application in exacerbating schizoohrenic behavior very

useful.

Since leaving Missouri, I no longer have chronic
schizophrenic pat ents and have no longer continued this
line of work.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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                    <text>xvi"

-

'

"

‘

"N

'

“‘

"

‘

‘

'W‘VM-W‘W'W“

"'

:-

"‘V‘"NI

vwv

..‘

..

m.-u...,..,.

.-

.

..

.__....

N

,

March A, 1970

Koliday Inn

?.0. 3012317
Aspen, Colorado
Gentlemen:

_
_

w—wwmw

Vleusa cancel the reservation that I made for my
attendance at the Western EEG ski tastings. I regrnt the

inconvenience,; please assign my
as I will not be «bl: to attend.

room

:0 another atcandea,

V.“

,
‘
w

9
-

w‘nv-‘w-w

Thank you.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>March

3,

1970

Mary J. Kauffman
Manager. Direct Mail
Advertising and Promotion

Book Medical Publishers
East Wacker Drive

Year

p414;

fr.

35

Chicago,

Illinois

60601

vary-smug,»

I)

.‘a't

""vawlmm-

Dear Miss Kauffman:

It has not been the policy of this Association to date to
use its mailing list fer non~scientific purposes. The next
meeting of Council is in October, 1970 and I will be glad to
present your request to the officers at this time.
Sincerely yours.

7w

Fink,
Secretary

Max
alwsyar.

Mme

[rpm-7x

1w
“

”75‘?!"

W
~'

:‘Z’mﬂrif!:1¢5'.i’v'€

.‘e’r'W

waiwram

E’s'ﬂ‘ﬂw‘l'r’ﬁ.

mmzzvmv;

MF:kp

M.D.

�</text>
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                    <text>ﬂnrch 1, 1970
Br.

A1

Bantam

ﬂinascia
Scat: Kaspital

Boston, Manaaahuuetts

meat A1,

I:

so thank you

with you at tbs Agar, 3nd I want
far participating in th: panel on training. Tau:

wan fun marking

noumanta war.

:90: haipful, Iné I

axculleuce of your programs.

must coagratultco yen an uh:

I in writing to c$k your approval for Dr. Javan Simeon
and his naaiataut, Dt. Jgnn Robson, to attend your farthcening
nympasiun on yoychaphnruncalogy 1a childrnu on unreh 11 3nd 18.
I undarltand the aynpotium will be bald A: the Cashing ﬂosyital
in Yruuinghan.

many

thanks,

an&amp; my

baa: regards.
Sinccruly yours.
Max

Fink,

M.D.

frofeauor of Psychiatry

mf/

‘

�</text>
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                    <text>Fr

,

m...

,

,

w

W -. -

.7“... .,.-_

..

.

.v.

n,

.-

“WW...

.7... ”V

_

m...

.. .._,.V _. ,

.1” .

.,..

,.

“‘

“1"

“PL

"urn-mtg“

March 1. 1970

(«II-um:

r
an:

Professor Alan Kraft

Department of Psychiatry
Albany Medical Collega of Quiet University
Albany, New York
ﬁaar Professor Kraft,

I have knawn of Dr. Keelar*a work for many years.
and nine; July, 1969, I have had more direct contact with
him in this Department of ?sychiatry. His record in North
Carolina is well known and his work there was of the calibar
tn receiva recognitian both by HIKE in its Carter Development
Program and by the University where he was promotad to full
Prefessor. Kin reasons for leaving ﬂorth Carolina seem to have

bten parsonalvv a desire of a New Yorker ta raise his family in
ﬂaw Yark-~ and not professional.

Since coming to New Ycrk Medical Collage, he has been
unable to make use of his abilitics~~ in part, because of the
liwited clinical facilities at his diagonal, and in part because
of the expcctntionu that funds ware already available, which were
indeed not yet awarded. ﬁe has carriaé out a teaching yragram
with psychiatric residenta and this has been done wall, for both he
and the students have been enthusiastic and they have raqucsted an
increase in their exposure to his teaching.

I believe him ta be a good researcher, capnble of undertaking prograns in aubutance abuse and schizophreniaww two subjects
of mutual interest. ﬁe writes well and his concaptualizatian of
a study program in cannabis was wall ptesanted. We understand that
tha project was racammended for support by the study atetian at
MIME but remains unfunéed because of the continuad lack of
a budget
for REV, rather than any inharent problem with the prtaentntion.
His persunality can best be described an raserved,
unassuming and mmdarately insensitive. He is forthright and cooperative
with his junior: and has exhibited the ability to relata to other
staff membara, particularly those in tha training divisions.

�Prof. Alan Kraft
We

.

.

.

.

.

.

.

.

.

.

.

. Page 2.

have not had an opportunity to evaluate his role as

administrator.

likeablo and cooperative in personal
matters, but uncooperative in his professional relationship with
a
I have

.
r

found him

part, this rooultad from the unfortunate assignment as
of this Division without an independent clinical base,
staff, most
requiring him to relate for patient mottoro with myRoaaaignmont
to
of whom are loyal to my ptinciplos and interosts.
him was difficult, and it soon become obvious that such a
partition of the limited clinical material woo not acceptable to
ma ; and a collaborative rolationabip with another Protease: was
him for
not acceptable to Martin. In largo port, I cannot bloom
have
not
his diaoppointmont, and I believe that his abilities
bad thn opportunity in this Department to oXprose themselves.

mo. In
member

«r.

W'fv”sz-m‘mwmuxw’mym-rsmuv.

'7‘“.

319.4,“.-

»«

v.
w

H'me

V731“

Ham

.»

'
.

l boliovo that he would do very well as a clinician
and a rosoarchot in a oooarate and well defined clinical facility.
Hie projoota will to wall prosentod and ovon in this competitive
climate» ohoold achieve rocognitoon and suyport. Ho relatos well
It
to students and bio toacniug will he acceptod with onthoaiaam.
him
this
$xooﬁmon
to
agpoﬁwtod
recommendation
that
3:.
was on my
Collage, and { bolﬁevo that if tho ?aoilitiao were aﬁoquato for
two oatallol programs, he would have been happy and have carried
out his work with distinction.
he should be given aoothor opportunity, and I am confident
he will be able
that if he to givan the facility and the authority,ﬁoxth
ﬁarnlina.
to achieve the potential doocriboﬁ in hio oath in

”M‘W‘V

.rw

v

I trust theoo

comments have

for tho succeoo of your program.

utility.

my

host wishes

Sincerely yours,

Pink, v.9.
Professor of Psychiatry

Max

of]

�</text>
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                    <text>March 1, 1970

Dr. Charlas Shagass

secretary, 83?
Philadelphia, Pa.

Re; Leo

Hollistar

.
-»

-—«“ml-‘

Dear Charles,

”at

V'

rat-r"

‘Wmtu-“ar'w'lﬂrﬁﬂllmn

Leo

It gives

Bollister for

Psychiatry.

me a great plaasure to rccommcnd Dr.
membership in the Society of Biological

I have known Leo since 1960. when we both served
in the Clinical Committce of the NIMR. l have found him to be
a sincere. industrious, creative researcher, with a flnc grasp
cf the physiology of psychoactive drugs and an extraordinary
interest in the biological effects of chess compounds. Ha has
written extensively in paychepharmacolegy, clinical toxicology
and has contributed extenaivcly to the VA collaborative study
programs.

He is among the fcw clinicians who have mace use of
the EEG in his evaluations, ané while I tcnd to disagree with his
conclusions, his data is wall collected and tell prascnted.
He

will make a fine
heartily.

recommend him

member

of the Society and I
Sincerely yours,
Fink, H.B.
Professor of Psychiatry

Max

�</text>
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Dear Professor Hippius,

for

I am writing on behalf of Dr. Milton Kletzkin,
membership in the CINP.

I have known Dr. Kletzkin for more than 10 years,
and followed his work with interest. He is an experimental
neurophysiologiet and neuropharmaoologist with special interests
in the the effects of muscle relaxants and sedative anxiolytice.
He is a fine speaker and has contributed intelligently to the
symposia in which he participated.
At the recent meeting of the program committee, I
put forward a suggestion that a symposium be organized to
relate the CNS effects of drugs in various animal species,
and I had his cooperation in mind for that program.

It gives

me

pleasure to

recommend

his

membership.

Sincerely yours,

Max

Fink, M.D.

New

York Medical College

Professor of Psychiatry

Prof. H. Hippius
Nervenklinik der Freien Universitﬂt

Berlin,

Germany

�</text>
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                    <text>M

April 30, I970
Dr. Sidney Merlls
Confral Islip State Hospital

Central

lsilp,

New

York

Dear Sld,

Enclosed is a rewrite of my prosenfaflon before fhe ACNP
In February. I Trust If us usefut and look forward fo,fhe

publlcaflon.

Sincerety yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp

enc.

�</text>
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                    <text>E

,3

g

April 28.

1970

Dr. Alejandro Zaffaroni
3401

Hillview

Avenue

Stanforﬁ Industrial Park
Palo Alto, California 94304
Dear Dr.

zaffaroni,

we are faced with a difficult drug dolivery problem, an&amp;
in reading ﬁrug Research Reports, read of the formation of A123 Corporation,
with its focus on drug delivery prohlems. I am writing to enquire whether
Alma can assist us in too following problem.

Naloxono is a spocific opiate antagonist. which we have
found useful in treating Opiate dependence (01in. Fﬁarmaool. Therap., 9:

563,577, 1%58). Go oral administration. naloxone is either rapidly
destroyed or poorly absorbed, for large cases (3.0 Cms/day) are required
to achieve antagonism to heroin for 24 hours. a minimum for therapeutic
usefulness. 0n parenteral administration, 0.6 to 1.2 mg/B hours are
needed to maintain effective antagonism.
ﬁalexone is produced from tocbcinc, a prosctibed drug,
and producing supplies for oral use is impossible. In our discussions,
we have focussed on parenteral administration. and considered the
development of a long acting parenteral form, possibly in a silostic
type vehicle. We proposed such a development to the usual research
funding agencies and have received sufficient initial support to under?

takc feasibility

trials.

If A123 is intorostcd, I would appreciate the opportunity
with
meet
to
you. I plan to be in San Francisco for National meetings
May 9w13 and can be reached at the Hilton Hotel or in ﬂew York (212~369 7900).
I look forward to hearing from you.
Sincerely yours,

mf/

cc: Prof. A.

Max Fink, 14.9.
Professor of Psychiatry
Director, Division of Biological
Psychiatry
vi.

Freedman

�</text>
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                    <text>«mm-m-mw——“ an
--

April 27,

.u'wrw.~!wﬁ‘nan—rawmm-u-vw.um ..

1970

Dr. Albert Silverman
Rutgers Hedical School
New Brunswick, New Jersey
Dear Al,

I look forward to participating in the APA Divisional
meeting in Newark in November. The program participants are all friends
and I am sure we will have an interesting experience.
the focus would be convulsive therapy.
program should focus on this, and the title
"Neurophysiological Aspects of Treatment" might be focussed in the
title, ”Neurophysiological Aspects of Convulsive Therapies”. If the
program is more general, and related to drug therapies as well, then
the title should be more descriptive, like " Neurophysiological Aspects
of Somatic Therapies".($omatic may be replaced by organic or biological).
Noch mentioned

If that is so, then the

My

best regards,

and

my

thanks for the

invitation.

Sincerely yours,
Max

Fink, ¥.D.

Professor of Psychiatry

mf/

“WV—warn.mw—v. -&lt;

�</text>
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                    <text>&lt;.'v;.rt-v—

April 24,
ﬁr. Turan M. 1:11
Missouri Institute of Psychiatry
5400 Arsanal Street
St. Louis, Missouri 63139
Dear Turan,
I have been checking my

v—qu

,rv-W

..
v-

viva“

.mwu-

5-

r
raw-aw“

mmmcr-m

1970

data
for your files.

sheets from your study.

data books, and found the enclosed
Don suggested I sand these to you

Sincerely yours,
Fink, $.ﬂ.
Professor 0f Psychiatry

Max

MF:kp
BBC.

�</text>
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                    <text>_

:

~

wwwwxw «n-r- A4

nuw

n—ww

Haw:

-v

w

1’f'I-W-'F‘I‘Tw_ﬂ”

smug-«an.

:.

~,

5‘.

,

-w "l ”.1.
,-.

:..—.;.:v—c-.~.~

vs..-“

A”.

u

,.., ,h.,.,w.r_c.,,.,,,,.,..

1.

7.7M

.4-

n.” “H“,

_,__

.V

Aprll 23, l970
_
A

l
I,
-

A

,..l-.v

—
—-.

Dr. Ralph Jacobson

Endo

IQOO

Laboratorlss

Sfowarf

Garden

Clly,

New

York ll530

mﬁ‘a-n-

‘_-.,mm—.-,;_.Wv

/v“\

‘C'IQ‘W:'-twrw"“-\vri

Door Ralph,
Some months ago, we dlscussod the posslblllly of a broad
cllnlcal lrlal of oral naloxono ln slnqle large dally doses
(2.4 lo 3.0 Gms) ln oplafs dependenf subjects. You wlll recall
That no roporfed our obsorvallon lhal dolly doses of l.2 and 2.0

falled To profecl our subjects beyond l8 hours lo 25 mg
lnfravonous heroln, bu? the? 2.4 and 3.0 Gms wore sffscflvo for

Gms

more Than 24 hours.

Upon your reassurance Thal Mr. Bovld Kloln, your vlcs~
prosldonl, had personally rooussfsd fhs suppllos be made avollable,
we rolurnod our romslnlng naloxone, so Thaf The larger lablols
could be prepared.

Durlng The pas? 6 months us have received monfhly roassurances
That naloxono would shorfly be avallablo. ln your message lasl
week, you slated fhal prlor calls on your suppllos. plus dlfflculflos
a? Molllncrodf Chomlcsl, plus expense and olher»oommllfmsn+s a? Endo,
made if unllkoly lhaf naloxono would be avsllablo for cllnlcal lrlals
before Soplember of The oarllosl, and roallsflcally, probably no?
unlll +he end of rho yssr.
Mosnwhllo, lho publlc press lndlcalss (from your release?)
an NBA for Narcan ls lmmlnonf ”wllh cllnlcal ovaluollon
expoclod To be complsled wlfhln 6 lo 8 monfhs on Tho drug's efflcacy
ln horoln and oplofo dopondonoo.“ Tns roporf makes erroneous
references lo the work In fhls laborafory, and oven allowlng for
roporfsrlal errors, l am concerned +ha+ l may be mlsquofsd - not
only #0 The press, but To rogulafory agonclos as woll.

lhaf

Our flndlngs wlfh oral naloxono ln 7 cases have been publlshed.
flndlngs wllh dosages to 3.0 Grams/day are confldenllal
and were reported lo you To supporf our collaboraflon, and were not

Our subsoquenf

avallable for

FDA

submlsslon or publlc reporllng.

V

.

,

,

‘

,ﬂ

V

_

,

�Fwwww

om

r
”aw-H

Dr. Jacobson

-2-

April 23, l970

»

A-vr

V.-—..n—P—..—«&gt;—-

i hope The misquoTaTion did noT
resulT from an Endo reloasa,
buT did come from an enThusiasTic roporTer's misquoToTion of
our
preliminary reporTs To The STaTo NarcoTlc AddlcTion ConTroi Commission.

‘i am wrlTing Today

for

The following

reasons:

i. To record my undorsTandlng of your Telephone call
oral naloxone ls noT available for clinical Trial in opiaTe dopendonco in daily doses of 2.4 To 3.0 Grams; and ThaT The earliesT
daTo for such supplies may be SopTombor i970.
ThaT

us during

2.

To requesT ThaT The supplies of naioxono, roTurnod by
The winTor, be made available To us once again. As
you

recall, we have boon able To adminisTer cyciazocino very rapidly,
proTochnq our subjecTs againsT The agonisTic offocTs of cyclazocine
by oral nnloxono. We have found ThoT 300 mg naloxone, 3 To 4 Times
a day for 3~5 days, is useful in cyciazocine lnducTion. We wish To
TosT This observaTion in 50 consecufivo addlcTs, and
require 4.0 Gms/
subjocT or 200 Ems. our presenT supplies are almosT exhausTod.
we would like To carry ouT This sTudy as
rapidly as posslbie.
Can you reTurn 209 Gms naloxono in 303 mg (or lOO mo) TablaTs To
us wlThln a monTh?

3. To suggosT ThaT we adhoro To our undersTandlng, ThaT
oTaTemenTs regarding our work, be made by prior iniTial consonT
You will recall ThaT our College has subscribed To such
an
undersTondlng. The enclosed reporT may roilecT a TransienT lapse
of ThoT undersTanding, and i TrusT does noT soT a procedonT nor docs
lT represonT a change in our undersTondlno. 0r doos lT?

public
only.

Ha.

ww-m‘rv—

layover»

&lt;-

w"

we“

u»

man-e:

r-c

.w;7~.w-

incidonTolly, Tho reporT of progress in a long acTing naloxone
prooaraTlon was encouraging. You will recall, however, ThaT The
figures you ouoTed, regarding The amounTs of naloxone
To onTagonlzo heroin in our subJeCTs, seamed ouT of Thenecessary
range of
our experience. i suggosT ThoT Those figures require revlow,
parTlcularly if The pharmacouTlcai chemisTs oro using Them as
bonchmarks in Their work.

will call your office in lo days, if i have noT heard sooner,
regarding your release of 200 Grams naloxono for a cyclazoclne-naloxone
i

sTudy.

Sincerely yours,

yruvap',"-‘WL

Max

Fink,

M.D.

Professor of PsychlaTry
MF:kp
GUC.

�</text>
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                    <text>April 23, 1970
Dr. w. Clarke Wescoe

President

Winthrop Laborarorids
90 Park Avenue

up

—

.gmq.&lt;—,,.p.~,y.‘

New

York,

New

York 10016

Dear Dr. ﬁancee:

.
.7,

WW“

We have read of your appoinfmonf as President of winfhrop
Laboraforids wifh inleresl, and 3rd wrifing To express our
congrafulaflons, and To bring To your offdnilon, cyclnzoclne ~
a valuable producf devoiopod by Sioriing~Win+hroo and now in

clinical trial.

Since 1965, cyclazocine has been under sfudy in The iron?menf of Opioid dependence. ﬁuch of ind dafa of clinical pharmacology,

parflcularly efficacy, seldcfed populafions, dosage, side effecfs
and Their managemenf, have been collecfod in our lahorafories and
have documonidd Those obsorvafions in numerous reporfs (see
aTTached 115+).

we

The clinical applicability of cycldzocino has boon impressive,
have been encouraged f0 underfakd more exronsive clinical
Trials « a siudy in opioid depdndenf subjecTs-is in progross.

and

wo

A principal
problem in fhls froafmonl is The daily administraflon
of dosage, for The oplafe dopendanl subJocf is noforiousiy unreliable.
We have urged The developmdn? of a long-acfing, injecfable (or oral)
form of cyclazocina. We are awaro of rho offorfs of Dr. Seymour
Yolles of lhe Unlversify of Delawaro, under an NlMd granf. Such an
effort alone seems inadequale lo The need, and we have suggesfed fhaf
ofhdr roufos also be fried.
w"

~

magnum

Our suggeslions have boon made lo various local and halional
health research funding sources and we have reconfiy been assured
of financial supper? for such a study.

weeks ago,
called Dr. Joseph Bird of STeriing-Winfhrop,
f0 sugges? a review of The clinical and technical sfudy programs
Some

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-

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we

_&lt;.

my

1

of cyclazocine, requesfing fhe opporfunliy To presenf our recenf
(unpublished) experiences, wilh The inienflon of sfimulafing renewed
inferesf in This compound, and a more acfive coilaborafion in developing
a long~acfing form of cyclazocine.

�I

am

*0 your

April 23, [970

~2-

Dr. Wescoe

wrtflng

affenflon,

This program.

To

bring +he programs daveioped

and

To

In your company
of
fhe presenf sfafus of
urge your review

Again, our congrafulaflons on your appolnfmenf, and our
bes+ wishes for your conflnued success.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

enc.
A. M. Freedman
Dr. Joseph 31rd

cc: Dr.

�April

2:,

i970

PUBLICATION LIST

Deparlmenf of Psychlafry
York Medical College

New

Freedman, A. M., Fink, M., Sharoff, R. and Zaks, A. Cyclazocine
and Mefhadone in Narcofic Addicfion. JAMA, 202: i9l—l94, I967.
Freedman, A. M., Fink, M., Sharoff, R. and Zaks, A. Clinical Sfudies
of Cyciazocine in NarcoTic Addicfion. Amer. J. Psychia+.,

I24: l499-l504, I968.

Freedman, A.

M.

and Fink,

In The Treatmenf of

63:
Fink,

M.

59—69,

and

i968.

iiil,

T.

M.

Basic Conceprs and Use of Cyclazocine

Narcofic Addicfion. Bril. J. Addlcf.,

EEG

and Human Psychopharmacology iv: Clinical
— A Review of
Progress

Anfidepressanfs.
I957—i967, Efren, 0., Cole, J., Levine, J. and Wiffenborh, J. R.
(E35.), U. S. Gov'? Prinfing Office, Washingion, D.C., pp. 497—
In Psychopharmacoiogy

507, I969.

Fink,

and Human Psychopharmacoiogy. Ann. Rev. Pharmacoi.,
9: 24i—258, I969.
M.

EEG

Zaks, A., Bruner, A., Fink, M. and Freedman, A. infravenous
Diaceryimorphine (Heroin) in Studies of Opiafe Dependence.
Dis. Nerv. Sysf. Suppl., 30: 89-92, i969.
Fink,

Narcofic Anfagonis+s and Subsfilufes In Opiale Dependence.
In The Presenf Sfafus of Psychofropic Druge, Cerlerfi, A. and
Bove, F. J. (Eds.), Excerpfa Med. Fdn., Amsferdam, pp. 428-43l,
M.

I969.

While, R.

P.,

Drew,

W.

G. and Fink, M.

of Agonisfic Actions of Cyclazocine
I: 3l7-330, l969.

Fink,

Neuropharmacoiogicai Analysis
In

Rabbifs. Biol. Psychia+.,

and Freedman, A. M. Anfagonisfs in The Treafmenf of
Oplafe Dependence. in Modern Trends in Drug Dependence and
Alcoholism, Phillipson, R. V. (Ed.), Bufferworlh, London,
M.

pp. 49-59,-l969.

Fink, M., Simeon, J., ilii, T. and Freedman, A. M. Clinical Anfidepressanf
Acfivlfy of Cyclazocine - A Narcofic Anfagonisf. Clin. Pharmacol.
Therap., ii: 4I-48, I970.
Resnick, R., Fink, M. and Freedman, A. M. Cyclazocine Typology in
Oplafe Dependence. Amer. J. Psychia+., I25: l256-2260, I970.

�PUBLICATIONS

(conflnued)

PRESS
0mm
IN

Fink, M., Zaks, A., Resnlck, R., and Freedman, A. M. Treatmenf
of Haroln Dependenca wlfh Opiate An*a§onlsfs. In purrenf
Psychlafrtc Theraptes, Masserman, J. (Ed.), Grune and Sfra?+on,
New York.

FjékgwM;;*Zaks, A., Resnick, R. and Fraadman, A. M. Opiafa Anfagonlsfs
In The Treafmen? of Heroin Dependence In Man. In Blochemlggi
Phannacotogy of Narcofic Analgesic qugs, Clouef, D. ZEd.5,
Plenum Publ. 00., N.Y.

.

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                    <text>-._

.
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Aprll 23, l97Q
Mr.

Charles

B. McCoy,

Presldenf

E. l. DuPont de Hemours, lnc.
DuPonf Bulldlng
Wilmlngfon, Dalaware l9898
Dear Mr. McCoy:

For more fhan lhree years, fha sfaff of fhls Department
of Psychlafry has collaborafed wlfh Endo Laboraforles ln fhe
cllnlcal fesflng of naloxone ln fhe freafmenf of oplale
dependence. Our flrsf cllnlcal frlals were reporfed In l968,
and slnce +hen we have encouraged Endo +0 make available
sufflclenf cllnlcal materlal +0 extend These frlals.

oral naloxane ls rapldly desfreyed, and fhaf
parenferal naloxone ls hlghly effecflva, we have repeatedly
recommended The davelopmen? of a longvacflng naloxona for fha
frealmenf of oplafa dependance.
Aware The?

Early In l969 we proposed such a development To varlous
agencles, lncludlng fhe Na+l0nal lnsfllufe of ManTal Health
and to The New York Slafe Narco+lc Addlcflon Cmnfrol Commlsslon.
We have recenfly been assurad a? flnanclal supper? from one of
fhase agencles, and may achlava addlflonal supporf from anofher.

for

Meanwhlle, we have requasfad Endo make supplles avallable
conllnued cllnlcal Trials, and once again, as ln l967-68,

hava recalved verbal assurances That fhe supplles will bﬁ
forfhcomlng, bu? fhey fall #0 malerlallze. A copy of our
communlcaflon ls enclosed.

lafasl

wlfh control assumed by DuPonf, and anflclpaflng The posslblllfy
of some changes in Endo's prlorlfles in fhe healfh care fleld,
l dlscussad our problems wlfh Dr.
Jurg Schnelder of your company
In February, and receivad a sympafheflc hearing.

"v“

'

�I

am

wrlflng

Today +0

brlng naloxone

To your

alfenflon.

Naloxone has some speclal publlc healfb posslbllllles. If
warrants a more rasponslva managerlal leadershlp ln maklng
oral supplles avallable for'audy, and ln exploring all feaslble
approaches To a long acllng parenferal form. May I ask your
alfenflon To fhls lmporfanf chemlcal and your encouragement ln
maklng fhe suppllas needed for conflnued cllnlcal sfudles?

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MP

:

kp

cc: Dr.

A. M. Freedman

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                    <text>“i
‘pu

w:-

we

e“

'vr

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.‘

,A,

-07.”.

r—r~.~7

n~vw

-vw—w~

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vamu

April
Wv-v'v'rr-m—ru

Hud—rm'an‘

2i,

i970

Dr. Loonfi H. Thompson
Program Chief, Menfai Heaifh Services
Confra Cosfa Counfy Medical Services
2500 Alhambra Avenue
Marfinez, California 94553

warm-‘1'.“

Dear Dr. Thompson:
w-ry

‘

applicafions for EEG analysis, as we do,if,
is of iiffle frue clinical value af presenf. if your elecfro—
encephalographer has a specific inferesf in esfabiishing a
compufer analysis cysfem, i would suggesf fhaf he confacf
Dr. Enoch Callaway af The Langley Porfer Clinic in San Francisco.
The computer

vlslf

i

would be pleased #0 have your eiecfroencephaiographer
us and describe our sysfem in.person if fhaf is useful.

Sincerely yours,
Fink, M.D.
,
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>~~u-. “7.5.”:

;-

mm

~

.77;

v:

.0

., .,

.1.

--.-

.p

--

-~.r.-

April

“7‘

--v—

2|,

,

r-iwvywv.

v:

,

w.

-.v

1',

i... .mm

.w

—

w-N

1970

Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Wilma,
Our cﬂnlcal GP sludy is prOQrosslng well buf we are in
need of additional placebo supplies. May we ask for l0 x 50

placebo?

affached.

A-label for idenfificafion of our present supply is

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

MF:kp

\

�</text>
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                    <text>,.-

y-.;

n,

«an»;

'ww"

1
ﬂy!

“:a'wv'l’w

.u-mw

‘1'

-.:

wacn

2.

-wv-..—y

r

«u—rwwnmr

rev

April

2|,

I970

Dr. Sidney Merlis
CenTral lslip SfaTe Hosplfal
Cenfral lsllp, New York
Dear Sid,
The
me In

enclosed recommendaflon of J. P. Green

error.

The

I

presume

draf+ of

in lO—l4 days.

my

fhls

was lnfended

presenfafton at fhe

was

ACNP

Fink,

M.D.

Professor of Psychlafry
Mszp

cc: Dr.

Samuel Gershon

To

wil! be ready

Sincerely yours,
Max

senf

for your commlffee.

�</text>
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                    <text>April

2i,

i970

Dr. Leonfi H. Thompson
Program Chief, Mental Health Services
Confra Costa Counfy Medical Services
2500 Alhambra Avenue
Marflnez, California 94553
Dear Dr. Thompson:
0-“.

.,
W

”mm

ynmum

The compuier

EEG

analysis, as

visif

i

Sincerely yours,
I"
A,

.t»

Max

a

navy“.

‘r

Fink, %.D.

Professor of Psychialry

rr-awurmwyrrwvmm

”VA-cushwr

do

if,

would be pleased To hava your @iecfreencephaiographer
us and describe our sysfem in person if Thaf is useful.

-

..

we

is of ilffle True clinical value a? preseni. if your eiecfroencephaiographar has a specific inferesf in establishing a
compuier analysis sysfam, i would sugges? The? he confacf
Dr. Enoch Callaway af The Langley Porfer‘Ciinic in San Francisco.

m-va-rw

.1

applications for

Mszp

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V."‘»V~'.'qV:"»-W --

»~.v&gt;~&lt;cr~-

April

0r.

Turan

M.

-

2|,

m

.wm

WW""’-

»

'~.l"av'lum~.1.n—:,

.7. .7

wﬂwﬁﬂgxw.’ v.

I970

lfil

Missouri Insfifufa of Psychlafry
5400 Arsenal Sfreef
8?. Louis, Mlssour! 63l39
Dear Turan,

Separately am sanding you fwo boxes which confain
reprlnfs and papers fhaf yau requesfed some Time ago.
I

I

*rusf

seeing you
My

you had a happy

In San

Francisco.

vacaflon and

I

look forward

best regards.
Sincerely yours,
Max

Fink,

MOD.

Professor of Psychlafry

MF:kp

V

A

WW7)!"

to

_-‘,.

7.

“Mp."

-1,

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V

�</text>
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                    <text>wwv

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mmwuvwww..n-- rumvrxwﬂ a-v-uv:

:‘r-u

awn;- "aw-v

saw v”,

i

”~st

r m.

«w-

l

, ,.

we

Aprli

A

..

2|,

l970

Dr. Charles Shagass

Easiern Pennsylvania Psychlafric lnsiifufe
Abboffsford Road
Philadelphia, Pcnnsylvanla

Henry Avanue
Dear

&amp;

Charlie,
i

would

like

for membership
copy of his curriculum

To propose Dr. Jovan Simeon

Society of Biological Psychiairy.
vifae is enclosed.
in The

A

sincc i965. He has
all
early clinical drug evaluaiion programs
parflcipafed
boih a? fhe Missouri insfiiufe of Psychiairy and in New Yerk.
He has established a program in child psychopharmacoiogy and,
i believe fhal he will continue +0 confribufe To our field.
Dr. Sinmon has been working wifh
in

#he

me

Sincerely yours,
f’iﬁX

F‘ nk,

My

00

Professor of Psychiairy
MF:kp
BBC.

�</text>
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r‘w'vnw—Vm‘xw

~

’

».

.

-

«

~

'

,;

’K?"

mpg—

‘

Aprll l7, I970

Ir.

Davld

Box I439

M.

Nathan

Amherst College

Amherst, Massachusefls

Dear Mr. Nafhan:
have presenled your leffer +0 8 number of my associates,
regref +0 say fhaf we have no poslllon lhls summer.
l

and

Your credentials are exemplary, and
anflclpafa Thu? we
wlll be worklng next summer. ln fhe evenf you are ln+eres+ed ln
parflclpaflng in sfudles of drugs in volunfeers, would be
pleased To hear from you.
l

I

Good

luck In yoursfudles.

Sincerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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c

April l7, l970
Dr. Norman

Pills

Chas. Pfizer &amp; Sons
Grofon, Connecticut
Dear Norman,
In response To your requosf, I am encloslng ceples of our
Neurosls" and
report ”Lacfafe Preclpifafed Anxiofy in Anxlely
our Ielfer lo lhe New England lgyrnal of Medicine which has been
published. The Two roporfs by Ferris Pills are enclosed, as well
as The negaflvo paper by Grosz and Farmer.
Our work wiTh

laclafe provided us with

an

lnferosfing

opporlunlfy lo Teal fhis Theory of anxiefy. Wifh fhe awareness
fhal calcium can block lacfafe preclplfafod anxiofy, sludles of
known an+l~anxiefy agonfs such as doaepln would be very
My

besf regards.
Sincerely yours,
Max

Flnk,

M.D.

Professor of Psychlalry

Mszp
GOCS o

lnlerosflng.

�</text>
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                    <text>.1,

'v’

April i6, |970
Dr. Eugene L. Nowickl

Assoclafo Director of
Clinical lnvosilgafion
Lederle Laboraforles

lll

New

Wes? 50in

York,

New

Sfreef

York

IOOZO

Dear Dr. Nowlckl:
l

and nofe
Based on

have read ins dais on Loxaplne Succlnafs wllh lnferesl,
lhaf you have an exienslve clinical ovaluaflon compleled.

fhls data your proposed sfudy is reasonable.

are focussod on lho principal of evaluating
drugs, and from The profile prodlcflng
clinical applications. We are now engaged in early Phase sfudles.
The enclosed sample profile analysis prolocol of one of our recent sfudiss
exemplifies our approach.
Our sfudy programs
The EEG profile of novel

I

The proposed sfudy is no? wlfhln our

Phase

lnleros? ai lhls flme.

in The even? Tho? you have oihar compounds which may require
I
ovaluallons, we would be pleased To review The animal data.

Thank you for your inforesf, and
opporfunify To work fogsfhsr.

l

lrusf

we

will have an

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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                    <text>'-

-ngnrw

uixwmr

u

,..‘v

r myT

."x
‘ \_,

"VI-V

,

,

‘

.

_

.

.

‘1“.

'ApPUI

Mr. Eéward

,

I6,

.A

M

-mﬂ,,.~-_n

ya...

._.

w

an“,

-m‘—mppwyv.

3970

J. Fitzgerald, Jr.

015?rlcf Direcfor of lnfarn&amp;l Ravanua
IZO

Ngw

Church Sfraw?
York, Haw York

Dear Mr. Ft?zgara0d:

Enciosad is a raquast from Dr. John Scigllano for a
cer+lflca+lan fhaf Tax 5?amp 457003 Issued on my behalf Is
proper and no? counterfeit,
tnscfar as we are In the mics? of a program of study

and addtftona! supplies era necassary,

earliasf affanflon fa fhis requasf.
I

wouId be

l

would appreclafe your

grafaful for your ceaparaflon.
Slnceraly years,
Max

Fink, M.D.

Profassor of Psychtafry

Mszp

n; v “pa-w

X‘N‘J":

"-r‘

‘v

.

7...,va

�</text>
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                    <text>April l6, l970
Dr. John A. Scigllano
Confer for Sfudies of Narcofic and Drug Abuse
Mafional lnslifufo of Manfal Healfh
5454 Wisconsin Avenue
Chevy Chase, Maryland ZOGIE
Dear Dr. Sclgliano:

Enclosod are xorox copies of my lelfer of March 23, l970,
The record of nmrijuana used, fhe pregress roporf of March l970,
and a xerox of The Tax Stamp. ln addlflon, a copy of a leffer
fhaT l have jusT wrlffen +0 fhe Dlsfric+ Diracfor of Internal
Revanue requesfing fhelr cerfiflcaflon fhaf The Tax Stamp has
indeed been lssued by fhom and is nol counfarfelf is also

enclossd.

in order To accomplish The prasen? range of

studies before

summer recess lnTerferes wifh our subjects, we would like +0
begin on Monday, April 27, and i would appreciafe your earliesf
affenfion #0 our reques? for lOO Grams of marijuana.

the

Slnceroly yours,
Max

Fink,

M.D.

Professor of Psychlalry
mf:kp

encs. Tax STamp
Progress report 3/l/70
Use of MarlJuana
Letter #0 IRS

�</text>
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                    <text>April i5, l970
Dr. Oidrlch Vinar

Psychlafric Research lnsfifufo
Prague 8 - Bohnice

Czechoslovakia
Dear Oidrich,

Just received your leffer of April 5.

8 and 9, as
in
communicafions
alphobofic order.
well as The grouping of free
My air ioffer of April i2 leff before i received Those nofes, and
i
now know fhaf you have received The full panel, including Tlfies;
and you know fhaf I have accepfed fhe l2 papers iisfed as the
”co~symposlum”, to be grouped firsi by a human ~ animal confinuum,
and second by confenf. i would suggasl an order of:
I

have

leberg

Sandison

Angrisf

Suchanek ~Frohilch
Eilenwood

Cohn

Lowander

Krwickaja
Knoll
Lyon
Guzok

Zabik
While we could hear i2
(mm

leborg - Krwickaja (ii-8)
in ”Free Communicafions”.

.A~A-,l....,v?h

w

,
.
-

Ia'nvnmvwm

"w

a-uxg-

.~

Wino

'

:r'r.im‘y

mn-

,
"'9

has

r

prefer 8 and suggesf fhaf
in
be included
fhe co-symposium, and #9—l2

reporfs,

i

would

is This feasible?

�Dr. Vinar

April i5, l970

-2—

Dr. Klelholz or I will accepf fhe responsibliify lo summarize
the symposium on Safurday, Augusf l5, in The plenary session.
As To your

You

quesflons

To The

(l)

Of course,
you should

(2)

For The co-chairman on cannabis, would you consider
Dr. Alfred M. Freedman of our College lnslead of
Dr. Keup? Dr. Freedman is planning +0 offend The
Congress, and is +he co-direcfor of a naflonei
Confer for Sludies of Subsfance Abuse.

if

a proposed chairman

is unavailable,

replace wlfh anofher colleague.

are doing a fine Job.

celebralion

Program Commlflee.

in Prague!

Keep

if

up ~

and we will have a

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychialry
MF :

kp

cc: Dr. P. Kielholz

�</text>
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                    <text>.v;...._~n-..

,

31,“.

A;.A-r~._v,._

my.

April l5, 1970
Dr. P. Kielnolz
Psychialrlsche Universllafsklinlk Basel

Wilhelm~Kleln«Slresse 27
4056 Basel, Swiizerlend

Dear Dr. Kieiholz:
have received various lefTers from fhe CiMP Program
Chairman, Dr. Vinar, and my answer To The lalesl is enclosed.
l

l.

The symposium The? has been submifled

filles lisfed.

conslsfs of fhe

2. The co-symposlum is fo be made up of submiffed "free
communicallons“. My leiier to Dr. Viner suggesfs we could have
all l2 (absfracfs enclosed) bul would prefer l—8, suggesfing
9~l2 #0 be presenfed in The "Free Communicelions“. The decision
is To be leff To Dr. Vinar.
asks That one of us summarize fhe proceedings in
The Plenary session. Since i am presenfing in fhe symposium,
3.

He

would if no? he appropriefe for you lo summarize ihe sessions?
i would be delighled To have you do so.
a

find

The papers of the Symposium and co—symposium may make
issue of a journal, and i would ask if you would consider

4.

This for your journal, Pharmakopsychlefrle? (lncidenlelly, your
leffer of February 9 was no? clear whelher you did indeed wishof
a reporf on anfagonlsfs and meihedone for a subsequenf issue

Pharmakopsychiefrie.)
i

look forward

to our

working Together in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychielry
Mszp

�</text>
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                    <text>April l6, i970
Dr. Burton w. Rocklitf
Regional Medical Director
Geigy Pharmaceuticals
255 North "D" Street
San Bornardino, California 9240i
Door

Burt,

Pardon the delay in answering your lettor, but i wished
to share your paper with Dr. Simeon, my co—worker, before
answering. We both found your report useful and productive,
and hope

that you/will publish it.

used a mean score for each item to
symptoms, before and after treatment.
showed
less change than most symptoms, and
it shows that insomnia
dopressed appearance, more change. This portrayal, however, is
poor and i would agree that if one has a large enough sample,
Anova is a good way to handle ' the data. Your reference to our
work is accurate.

report, we
develop this profile of
in our

refer to the "purely antidepressant
interesting idea, but one that may need more
actions of drugs”.
oxpounding since ”pure" depressions seem very rare in our populations.
in this regard, the assertion that anxiety, tension and fears are
not part of the primary disease process in depression is difficult
On

page l3, paragraph 3, you
An

to accept.

sorry we failed to credit your work - i did think it Wealready
was in the public domain, since l've known it for some yoars.
will give you proper credit in our next study of depressives.
i

am

Meanwhile, come and

visit

us when next you are in

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

New

York.

�</text>
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                    <text>April 11,
Pergamon Press

Elmsford,

New

1970

York

Gentlemen:

Kindly enter a continuing subscription to the
Journal of’Esychiatric Research, effective with the Januari,
1970 issue, addressed to:
Fink, M.D.
Department of Psychiatry
New York Medical College
5 East 102 Street
Max

New

I would also ask that the
sent.

York 10029.

1969 volume,

if still available,

be

If I understand the instructions correctly, this
subscription will be at the annual rate of $10., since we are

already subscribing as a Department throgh our library at
Metropolitan Heapital.
and

as

bill

Please make the subscription rehewable until cancelled
us annually.

billed.

The 1969-1970

subscriptions will

be paid as soon

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

mf/

�</text>
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