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                    <text>November 21, 1969

Dr. Doris H. Clouet

Associate Research Scientist

State Research Institute
for Neurochemistry Drug Addiction
Ward's Island, New York 10035
New

York

&amp;

Dear Doris,

Enclosed are the two manuscripts requested for your
volume on ”Biochemical Pharmacology of Narcotic Analgesic
Drugs”.

I regret the delay, but considering our dual appearance
in your volume, I think we have done reasonably well.
My

best regards.
Sincerely yours,

ﬂax Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>Hovambar 31, 1959

ﬁr. ﬁtapban

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Bernstain, M.ﬁg

Program Baud. ECﬂEu

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to warrant nn aspandtd discussion by the ﬁcﬁﬁu group in gay.
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                    <text>,mqu

&gt;xn

u:

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...,..v

_

.vw-

&lt;

'v'

w-a-wvrmv-r

"a

'

ww-=ann'wn"kuvn

.

November 20, 1969

vane-mur-

no...

”imam"

Mr. Herman Volumen

Raffmen~Le Roche

M

Rutley,

"Y‘t

a
.éﬁ‘yll

New

Jersey

Dear Mr. Heisman,

I went to thank you for your thoughtfulness in sending
volume
me the
by Kelee and the reprint by Whitman and stern. I
had reed the reprint before, and found
most useful. The book
The
found
end
excellent.
I
was now to no,
meeting must have been
e spirited one, end I regret not having extended 1:. But the volume
is a substitute, and I found many citations of special interest to

it

,w.

‘WWW'M

my

it

work.

-

"("11

I have written the

3.4"”

’9‘51'77“

‘1‘

T‘ﬂ’ii‘x

first éreft

of the ptotocﬁl which we
discussed. Theta ere
things that I will have to check before
sending it out, but I ohould'heve these facts within the next 10 days.
a few

Again,

“WK

my

thanks for your thoughtfulness.

w"“,ﬂ;wt‘(-vl€"'ilﬁ?§

Sincerely yours,

‘
‘

I!
1

Fink, M.D.
Professor of Psychiatry

Mex

'1'”,

,

A,

‘

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.

mf/

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                    <text>.u—vw. ,

.-

w.vwwm.ﬁm.wrmwvm_ewymw_

".77

.V

,,_., WV .

w“-

”WVW

_.. ,...v-.

November 19, 1969

Dr. P. Kielholz

Psychiatrische Universitatsklinik Basel
Wilhelm-Klein-Strasse 27
4056 Basel, Switzerland
Dear Professor Kielholz:
I am

delighted that

December. I, too, plan
and we should make time
that week.

we will be able to meet early in
to attend the symposium in Mexico City
available during the first part of

I do not plan to be in

I would be

New York on December 5, otherwise
pleased to take advantage of your kind invitation.

I look forward

to seeing

you in Mexico City.

Sincerely yours,

BMthm,Mﬂ.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>November 19, 1969
,

Professor

Max

Hamilton

Department of Psychiatry
University of Leeds
15 Hyde Terrace
Leeds 2, England

Dear ﬂax,

of you to visit with us and to permit us
to tap your experience and wisdom. My associates and I think

It

was kind

you.

I
way we

embarrassed about the hotel, for that is not the
ordinarily treat our visitors.
am

Please accept the enclosed as

expenses.

a token

to defray your
~

Sincerely yours,
:
m—m

Fink, M.D.
Executive Director

Max

Mszp

�</text>
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                    <text>ra

2w:

,

November 19, 1969

Dr. Gerald L. Beckloff
Director of Clinical Phxrmacology
Marion Laboratories
10236 Bunker Ridge Road
Kansas City, Missouri 64137

Dear Dr. Beckloff:
We have reviewed the data of our pyrovalerona study
(your 010—022) in response to your letter of Havember 11.
We

carried out

one placebo.

our report.

20

trials

The placebo
The ages and

The remaining

with pyrovalerone and
omitted in Table 1 of
dates of testing are attached.
—

19

trial is

supplies have been destroyed.
Eincecely yours,
H.(.
Professor of Psychiatry

Hax Fink,

�,.

7-

“ya—“.7..." ..

..—mn

”3.7

”Kw—s

w.

November 19. 1969

Pyrovalorone

—

BEG

Study

Date of Experiments

“Age

(all

P.I.

25

4/8

M.I.

21

4/11, 4/24

5.}{.

23

4/18

R.L.

22

5/1

F{'F.

22

5/2, 5/27

26

5/9

22

5/9

25

5/26

6/3, 6/13

$%.L.

22

R.G.

22

6/.3

B.G.

22

6/25

J.B.

20

6/26

M.D.

21

7/11, 8/6

W.C.

21

7/17, 7/24

-

6969)

�</text>
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                    <text>November 18, 1969

Ex. Kaith Sehnert
COMEED

Rockvilla, Maryland
Dear Keith,

It

was kind of you

:your new position and the

opportunity.

ta sand me tha informaticn about
activities of COEMED. It sounds like a fine

Our own work has prograssed well. The EEG analysts that
projected in 1965 as a technique for the evaluation and classification
of psychotropic drugs in mag is now an oparntionnl technique. we have
rec¢nt1y classified doxcpin; previously ideptlfied the sedative propertiaa
of fenfluramine and the antidepressant qualitiea.of cvclanocine; and
are now busy identifying three navel comveunds for three different firms.
The same techniques are also under gaudy by my associate, Dr. 1:11 in
St. LQuis and he has some similar data with other compeunda.

we

I believe thg techniguaa are now at the stage where they
generally. It may he of interast to you and your
assaciates to visit our lateratory and observe the processes in operation.
can be applied more

-

to your

Again, my best wishes for your auccaaa; and I look forward
your convenience.

visit at

Sincerely yours,

Professor of Psychiatry
mil

�</text>
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                    <text>November 17, 1969
Mr. Marvin Weisberg

"

lth'ﬁ“;

War

.

Profcaaional Saminar Consultants

Oceanside,

New

York

Van-r.

~

gnu-raw

1,1

Dear Mr. Whisberg,

-'——w‘

1.5"

2-,

"."w’.

,v‘

.gm—z

ﬂ
1::-

I ragrat that fund: are not available for my attandancc
at the Third International Cousteau of the Academy of Psychosomatic

Medicinc through

my

institution.

«'0'sz

”ﬁg-p

n",
,5.

212-

..—_

I want to thank Dr. Dorfmnn and your organization for your
kind invitation, and take this oppartunity to extend my bust wishes for
a successful congrass and a successful New Year.

1,1-

A,

Sinc'rely yours,

yaw".

r;

-.&lt;arxw&lt;yzz,zqrv52rwy~pm

Max
21‘5"».

vv‘rt‘yv'

3:
out:

19513;?”

5»,

95721;”

fw—‘Qw,

Pink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>Novembar

V41

.

""z'E-umVi.ur-vr

Mr. Garage

13. 1969

Salazar

Intonavno da MBxico
,g-L-

New

York, R.Y.

J'Nm'w'.r

“3-4,;

Dear Mr.

Salsar,

a supplement ta

Enclosed

is

PTA 35625

behalf for

my

check in the amount of $30.00, as

which

you to issue the ticket
the amount of $270.

will petuit

on

my

39

Kindly send the ticket to my home address*
Arleigh Road, Great ﬂack, Haw York 11021.

rx—nwt-awurﬁ:

NY—MEK~HIA~JFK,

1n

.Awmvv—‘wrn.

An
Frag-Wavy

portion

'open'.

JFX~MEX

I explained to your lauistanc, I want only the
November 30. with tha remainder

ticketed for sunday,

Thank you.

Sincerely yours.
Max

mf/

.w

/

.
A.

\RTWF

a

.‘.'—‘,r‘l¢"f‘IWWn€"Ii'Y“-Irﬁ‘i

.1

Fink, M.D.

�</text>
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              <elementText elementTextId="41353">
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                    <text>November 13, 1969
Dr .

Fritz Freyhan

St. Vincent's Hospital
153 West 11th

New

Dear

York,

New

Street

York 10011

Fritz,

In making the arrangements for the president's reception
are faced with certain decisions and I would like your
judgment.

we

A

cash bar will require each guest to pay $1.65/drink.

Our charge would be $35 for each
two bartenders be available.

bartender and

I am

requesting

Canapes may be purchased in one of two ways « a fixed fee
of $6.50 per person for a two hour cocktail party; or our
purchasing a quantity of food that we think is adequate at
varying costs per tray. A copy of their costs is enclosed.
The management suggests sixteen pieces per person as a reasonable
average, especially at that time of day and for a two hour period.
I

am

unsure as to the number of people who might attend

but estimate 80 to 100. If we accept the number of 1500 pieces
and use the minimum costs, I come to $700-$800.

If

take a fixed cost per person we are then dependent on
the management providing enough food. If we do it by the tray.
I believe I can request the managmenet to deliver more trays
within a short while if the demand requires. I would like
to request a variety of hors d'oeuvres initially on the basis
of 1200 pieces (12 pieces/person) with the proviso that we
order more as necessary (and funds allow).
we

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

3F:kp

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                    <text>I‘ 1

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&lt;-

Advil-1115!!!

w;

Rovomber 13, 1969

Dr. Dieter Bente
Universitats-Nervenklinlk
University of Erlangen

Schwabachanlage

Erlangen,

10

West Germany 8520

Dieter,

Dear

regret the necassity of sending the night
from the presentation. 'When we first
withdrawing
letter
received your invitation, neither Dr. Freedman nor I were
really aware that this was our holiday weekend. We both
have sons away in college and for this holiday our children
are coming back. Thanksgiving has always been a family
holiday and we both feel the necessity of staying home.
I very much

Harijuana, however, has become an important problem
in this country, and from what I hear, In Europe also.
I am trying to arrange a session on marijuana at the GIMP
in Prague. We are carrying out active studies in New York
and I am also planning a study in Athens late in the spring.
Perhaps there will be another occasion on which we can present
our data on marijuana in Europe.
My

best wishes for

a successful symposium.

Sincerely yours,
Fink, 3.9.
Professor cf Psychiatry

Max

Mszp

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                    <text>wry-avF'r‘rv‘w—W

‘4‘w-"m‘

~x'--‘

Hummer-m4“

way. u-

.

.11.

w y vw.‘

r q-«nwm-y-W-xwumuu-w~-~—v.(.-ym-M‘wa

aw" u.- -N—v V.....,.-,

»

,l

7-.-

“w

‘

a...

w

.

n...

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.7".

WV

November 13, 1969

Dr. Alfrod

M.

Freedman

ﬂepartmont of Psychiatry
New York ﬂedical College
New

York,

New

York

Dear A1,
In making the arrangements

for the president's reception

are faced with certain decisions and I would like your
judgment.

we

A cash bar will require eaoh guest to pay $1.65/drink.
Our charge would be $35 for each bartender and I am requesting
two bartenders be available.

-

mwwmrv-yr

l
‘

:u'v’w

Canapos may be purchased in one of two ways - a fixed fee
of $6,50 per person for a two hour cocktail party; or our
purchasing a quantity of food that we think is adequate at
varying costs per tray. A cepy of their costs is enclosed.
The management suggests sixteen pieces per person as a reasonable
average, especially at that time of day and EOr a two hour period.
I am unsure as to the number of people who might attond
but estimate 80 to 100. If we accept the number of 1500 pieces
and use the minimum costs, I come to $700a$800.

If we take a fixed cost per person we are than dependent on
the management providing enough food. If we do it by the tray,
I believe I can request the managmenot to deliver more trays
within a short while if the demand requires. I would like
to request a variety of hers d'oouvres initially on the basis
of 1200 pieces (12 piocos/person) with the proviso that we
order more as nocessaxy (and funds allow).
Sincerely yours,
Fink, M.9.
Professor of Psychiatry
Socretary

Max

MF:kp

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November 13, 1969

Dr. Joseph G. Bird

Director of Experimental Medicine
Sterling-WinthrOp ResearCh

90 Park Avenue
New

York,

Dear

New

Institute

York 10016

Joe,

Enclosed are the latest group of reports on cyclazocine,
representing patients #0100 to 0114. You will note that most
of the subjects of this group received an induction period
which was much shorter than previously and as a consequence
suffered insomnia, floating feelings, nervousness and irritability.
In most instances we have given the patients oral naloxone first
as soon as symptoms occurred and more recently on patient demand.
Thank you

for your assistance in carrying out this study.
Sincerely yours,
Max

Fink, M.D.

Professor of psychiatry

Mszp

�</text>
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                    <text>mvwmr.-_

.ﬁ

w»,—

V

7l_

&gt;

&gt;

rw.—_m

m.-vv-»_v____..__._,_.'.,v7 w.- _____.._-l.__

wt- l

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v

.mé"

‘K'

‘

{-2

I
‘4

.64,‘

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natu'gsw.

i

i

November 13, 1969

l

‘maxurt

Br. Michael Taylor

9309 Murillo Avenue

"kﬂk-;£&amp;

Oakland,Callfornia 94605

$5M

Dear Hickey,

@519“.

can't recall sending tho drug dosage paper

anywhere else.
would
he
wish to
send
Sr.
like
Kety
may
to
to
if you
publish it. Kathy can send a c0py from here, forging your
V

and

I

it

signature
My

on

the appropriate

rugs“

-

letter.

.

best regards.
Sincerely yours,
«11—A-

N

Fink, M.D.
Professor of Psychiatry

Max

an:

-

w...»

'
4m.

MF:kp

yr-gqg.

.mr

N

�</text>
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. "—w

w,

,,

.—

m

vawwmwmw.”V...v..w.—

m... "w F—Vv'-

November 13, 1969

Dr. Gaston Castellanos
Instituto Nacional do Neurologia
Insurgentes Sur 50. 3877
Mexico 22, D.F.
Dear Dr. Castellanos:

It

of you to invite me to attend the Second
Seminar in Mexico City. I have been notified

was kind

International

by Aeronaves of a

ticket

—

thank you.

In checking the program I believe I an scheduled for
December 3 or 4, and I will arrange_to be there at that

time.

I look forward to visiting Hexico City and I am taking
this opportunity to bring my two young daughters with me.
The notes do not state where the mooting is being hold, nor
For this reason, I have
am I clear as to:hotol arrangements.
made arrangements with hotel Camino Real. If this is satisfactory
with regard to the meeting site, please let the reservation stand.
If not, may I call on you to make a more suitable reservation?

I will need a room with
one twin.
1

look forward

regards.

three beds or

to seeing

single

two rooms, one

you about December 1.

My

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MP

:kp

best

and

�</text>
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                    <text>my:
-

\

Wu

'“29&gt;'

murmx

w—v

r-—.

wwvmww-r

November 12, 1969

.

Dr. Richard

J. Glavin

Director, Division of Psychiatry

North Shore Hospital
Community Drive
Modhcssct, wow York
Door 9r. Glarin:
A

few weeks ago, Dr. A. Learner

invited

me

to see a patient

tho psychiatric service of North Shore Hospital. is I
told him, the nursing staff was most cooperative, and expressed
a superior understanding of the patient. The records were
excellent, and my review was an unusually satisfying experience.
on

When

North Shore Hospital opened, I was in

Great Neck and participated in

‘

its early

practice in

development. ﬂy interest
electroencephalography permitted me to develop

in clinical
the laboratory at North Shore ﬁospital (and also at Long Island
Jewish and aillsido). My intorost in the community led to
an active program with ﬁassau ﬂ? ﬁocicty, with my cloction
as president in 1959~603 and the fbunding of tho Nassau NP
Newsletter as historical phases of that interest.
Since 1967 I have been teaching at

Now

York Medical

College,

primarily for rosoarch programs in biological
particularly in addictions, psychopharmocology

and roSponsiblo

psychiatry ~
and convulsive therapy.

During those throo years I have frequently regretted
not rooostoblishing a community base. I live in Croat ﬂock
and the daily commuting to ﬂow York is becoming more of a
chore. Stimulated by my recent visit I am writing to explore
the possibility of ro—ostablishing a relationship with North
Shore-Hospital. A copy of my curriculum vitao is enclosed.
I

will call your office next

Thank you

week

to discuss this further.

for your interest.
Sincerely yours,

‘4“ Fink,

434.0.

Professor of Psychiatry

Mszp
cc:

William

'1‘.

Human

�</text>
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                    <text>"""W"?

a.“
L‘

1

November 12. 1969

Dr. ﬁichael L. Grozier

Associate Clinical Research Director

The Squibb
New

Institute for Medical Research

Brunswick,

New

Jersey 08903

Dear ﬁr. Groaior:

have reviewed the clinical records and the summaries
of forty patients in a cross—over fluphenazine decanoate fluphenazine enanthato study completed in our laboratories
in 1968. The report previously submitted to the conference
at Sitges included 62 patients treated with decanoato.
We began our study with dooanoate and many of the
early
casos suffered secondary effects, in part related to the
trials by the staff in obtaining their experience. The data
of the crossover group will be more comparable and a more
representative picture of the secondary effects is shown
on the attached table. It is apparent that the compounds
are quite similar in their effects in this population.
We

.uuuvi'al'

Sincerely yours,

_

'
vi.

.u,

vrww

MM

are-aw»

MF:kp
'xiys‘wwlwﬂk‘,“

-:-

tam.

2..

"nai-

A,TWAWMMK”W'W'?M'VWWW

w

'

"an”

Pink.

‘10:)-

Profossor of Psychiatry

"New."

�ﬁgx

I.“J

Novambor 12, 1969
FLUPHENAZINE

DECANQATE

-

ENANTHATE

Crossover 1967-68

8&amp;ng

Parkinsonism

Elma

m

125

so

FF.

4

3

s

2

4

s

4

4

s

9

s

5

13

17

12

11

32%

42%

1m

27s.;

AN“

Akathesia

&amp;

Restlessness

Other
Sum
%

N

”L

,
~.;.-.

:7

1'...

a;.wmvvv:1.-v:rn

I

40

incidcnce

�</text>
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                    <text>.1

1......"

m -

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. &lt;~r1m
v

"v”;

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.

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Wang-m.-w- .. w-wrw...-——~w,......«.

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my.

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own

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-

Human

‘rs-

Novewher 12, 1969
wavy-wmmvwwywmm

Dr. Richard B. T. Cowan

my

-:

“my“,

w‘mawr-z

Rational Institute of Mental ﬁealth

Clinical Research Center

Leestown Pike
Lexington, Kentucky 40507

,.
vu-ﬁzr

A.

ﬁear Dr. Cowan:
We

would be pleased to have our questionnaire used in
A copy of the report and the questionnaire form

Lexington.

are enclosed.

questionnaire is under continued study here, and we
to share any data with yOu. iichard Rosnick,
of
in
this study and Stanley Feldstein, Ph.ﬁ. has
charge
is
data
the
supervised
handling. It may be useful for you to
write or call these men about specific questions that you
may have (R. Resnick (212) 360-6740; 3. Feldstoin (212)
369-7900, Ext. 248); or weuould be pleased to welcome a
The

would be pleased
&gt;

:.V":',

,-

:rvmv-anvm

4-4.

w
v‘

49“:va

visit.

Sincerely yours,

.am

av-wv

wrap:-

Max
'F'ﬂ‘WC-‘WHU’VWII

"an

1.

{F'v‘l‘li

.:
u
-

«av-v.2

r
WM.“

"1'

0;

«any»?

«'1

vi?!"

r!
"

w

gagggwnrr:

“and,

or.

'
[Venmvw

Fink, M.D.

Professor of Psychiatry

M.D.

,

V

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7,.

-—

A

A...

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".Vw.w—~W——v—w—w~rn-mwvw

November 12, 1969

Dr. A. G. Karczmar
Pharmacology and Therapeutics

Loyola University

Stritch School of Medicine

First Avenue
Hines, Illinois 60141
1400 South

Dear Alex,
I look forward to welcoming you in New York
Movember 18, about noon. May I suggest that you

to LaGuardia and a taxi to our offices at 5 East
(corner of Fifth Avenue).
I have asked Dr. Abrams,who

is

my

next Tuesday,
take a flight
102nd

Street

co-worker in the project,

and Dr. Ehrenpreis, of the Department of Pharmacology of the

New

York Medical College

to join our discussion.

would like to focus our discussion on the biochemical
aspects of the convulsive therapy process. I am particularly
interested in assaying cholinergic mechanisms, possibly in the
spinal fluids, in patients now undergoing selective varieties
of induced convulsions.
I

Dr. Abrams has just completed his residency, but did have
two years of military experience and so is Board eligible.
Dr. Ehrenpreis is noted for studies of acetylcholine.
we

will, of course, defray your expenses

honorarium.

I look forward

to seeing

you.

My

and provide an

best regards.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

.

uku—u—

MF

:kp

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                    <text>November 12, 1969
M. Kraft
Professor and Chairman
Department of Psychiatry

Dr. Alan

The Albany Medical College
Albany, New York 12208

of Union Univ.

Dear Alan,

for your inquiry about an asoociate for psychoto mind - Dr. Martin Keeler, who
pharmacology.
North
from
Carolina,
appears to be unhappy
is at our College
Thank you

Two names come

New York-living
too expensive and all that, and
Dr. Gerald Klerman of Yale. He has had a new chairman and
has given up his position as Clinical Director of the
Connecticut Mental Health Center.

with

—

an eminent drug therapist with a keen
interest in hallucinogens. I find him sophisticated,
knowledgeable and capable.
Dr. Keeler

is

Dr. Klerman

is

nation's leaders in psychointerests in theoretical biochemical

one of the

pharmacology, with special
aspects of drug therapy.

I can recommend both men highly.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>November 12, 1969

Dr. William Westlin
Ciba Pharmaceuticals
Summit,

New

Jersey 07901

Dear Dr. Westlin:
I look forward to seeing you on Friday afternoon,
November 21. This division of the Department of
Psychiatry
has maintained active study programs for new drugs in

adult psychotics, ambulatory neurotics and addicts since
1966 (prior to that I established ECDEU units at Hillside
and St. Louis).

5'“
-‘

'
.

ju'ﬂn'a'

E.

i
1

g
E

§
gr
E

E

About one and one-half years ago we decided to
establish a child psychopharmacology unit for the purpose
of developing techniques to assay new drugs in children.
Prior to accepting new drugs, however, we would like to
have experience with established compounds. A protocol
of that study is enclosed. You will note that we desire
to work with Ritalin first, preferably in a liquid syrup

or concentrate.

E

I look forward

l

to discussing this with

you next week.

g

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>November 12, 1969

Dr. Benjamin Pasananick

Associate Commissioner, Research,
Department of Mental Hygiene

Albany,

New

York

Dear Ben,
I

am

grateful for your call and wish you all
to Albany. I am pleased that the move
closer relationship to the medical school.

most

success in the

may

allow a

move

Dr. Freedman has begun negotiations with Al Miller
regarding our relationship to a section of Manhattan State
Hospital, and it is probable that Dr. Morton Wachspress
may fulfill the role of a joint director of the unit.
Dr. Wachspress was a young researcher with me at Hillside,
who progressed to administrative psychiatry. He is soft’
spoken, knowledgeable and alert to the needs of research.
I am pleased to recommend him, and if he is appointed,
I would look forward to undertaking some studies with him.
I would urge you to take the time to meet him when the

occasion permits.
My

best regards.
Sincerely yours,

WE‘T‘WV’PWY”

.

Max

“1’9”?

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>m

w&lt;v’ “mi—“VD.

.

.

.-

m

~.~

».-

._.—w...‘» mm—movw—nw—s—
u-«-—.w1,v~n.=y,...‘.m. w, (1".1.

Novambcr 9, 1969

Prof. Dr. P. Kielholz
Paychiatriache Univcrsitatsklinik Basel
Basel, Switzerland
Daar Prof. Kielholz,

ER‘

I have waited before developing the 1970 program of the
with you, until the many small details aboat tha maeting,
the dates wet: settled; and anticipating your visit to New Yorkspecifically
as
being sufficiant time for us to deveIOp the program.
CIR?

In year

at the beginning of

letter

Daccmber.

you remark

that

you

will be in

Please note that I V111 be away from New York tron
to December 7. Can you givn no a specific time when you
will be in New York for us to meet 7
November 27~29.

perhaps

we

I plan to attand ch: German CIHP 1n Nﬂrenberg from
If it is possible for you to be at the same meeting,

can discuss the program than.
My

best regards.
Sincerely yours,

w

‘rw‘w‘

-

rvr-

Max
0

:1.”

haw"

Nani-W

‘-

1

‘m'zd‘n‘hpw'.

pnr

'1”:

n'v'w

:~.,.nw

.m’:’r

Fink, M.D.

Professor of Psychiatry

"may;

mf/

y

ﬁ.

York

Novamber 26

m'

"wow

New

‘

ﬂ
;
‘

g
A

”

�</text>
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                    <text>November

7,

1969

Dr. William Tabor
Robins Company

A. H.

1407 Cummings Drive
Richmond 20, Virginia

Bear 8111.
To correct an oversight, I have requested approval by
the Formulary Committee of Metropolitan Hospital for a 1 year
trial of butaperazine (Repoise) tablets. If agreeable to you,
would you either ask your reprosontative to make supplies
available to the pharmacist, Mrs. Crusade or deliver a supply
to my offico. I could suggest 1000 tablets each of 10 and
25 mg

to start.

Whoa

;

approved, I will ask Dr. Simeon to make our

reports available to the staff.

Sincerely yours,
Fink, M.D.
Profossor of Psychiatry

Max

Mszp

�</text>
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                    <text>November

7, 1969

Ur. %. Ralph Kaufman

Department of Psychiatry

Mt.

New

Sinai Hospital

York, New York

Dear Ralph,

is applying for a fellowship in
psychiatric research (psychopharmacology) for July 1970.
He reports a 2 year residency in psychiatry at Mount Sinai
Dr. S. Venkat Ramani

HOSpital, July 1966 - June 1968.

It

helpful to obtain
Sinai with emphasis
intelligence and dependability.
would be

service at
Many

Mt.

an
on

evaluation of his
his individuality,

thanks.
Sincerely yours,
Max

Fink, M.n.

Professor of Psychiatry

�</text>
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                    <text>.,_.

o_.,.._~r_...—.V.—v,

w..."

m.

November 7, 1969

Dr. Robert A. Turner

Consulting Pharmacologist
289 Greenwich Avenue

Greenwich, Connecticut 06830
Dear Dr. Turner:
Thank you

for your letter regarding the

EEG

changes during

a cycle of Opiate addiction in nan. Enclosed are reprints of
our clinical studies; and a pro-print of our latest report on
the EEG effects of heroin and naloxone as submitted for

pUblication.

The drugs of greatest need in opiate addiction is an
antagonist of long duration of action (24 hours minimal,
7-14 days optimal), of high potency, with minimal secondary
effects, and without dependence potential. Cyclasocine is
potent and of long duration but the secondary effects so
cannon as to preclude general usage. Naloxone is potent and
without secondary effects but its duration on oral use too
short. We would like to see a long acting analog or form of

naloxone for
-.

'5).

.
w-m

”Maritza

'

.mmvmm

r”.

'J’ﬂ'wwna‘m'w'

mac-r-

a

clinical trial.

Your Specific question is difficult to answer categorically.
Subjects taking opiates during the development of dependence
show EEG changes from their baseline record. When dependence
is established, the BBC shows a characteristic highly synchronized,
alpha dominant record. As withdrawal is instituted, the record
is upset and slow waves, irregular patterns and fast frequencies
become prominent - only to have the record return to the alpha
dominant record with an opiate.

If the opiate dependence is relieved, a more “normal”
record will assume prominence - this may be of any type, and
should be distinguishable from the addicted record, in most
instances.

�'

‘n

Dr. Turner

~2-

November 7, 1969

There is, however, no single characteristic "drug" record
and ”clean" record, and the differences are to be found in

comparative or sequential recording.
Thank you

for your interest.
Sincerely yours,
Max

5

Fink, M.D.

Professor of Psychiatry

f

Mszp

�</text>
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                    <text>November

Dr. Thomas Spitzer
E. R. Squibb and Sons
Georges Road

New

Brunswick,

New

Jersey

7,

1969

08903

Dear Dr. Thomas:

Enclosed is a protocol approved by the appropriate
committees of the College fer the development of a psychopharuecology study in childhood and adolescent behavior
disorders. Fluphenezine is one of the compounds that we
are interested in testing in our initial studies.

desire to assure the delivery of medication
to our patients, we are making every effort to provide the
medications in liquid vehicle or concentrate form. I am
writing to request your support for this study program by
providing us with Prolixin elixir 0.5 eg/cc as well as
identical placebo. It would be most useful to have a supply
of the 60 cc droPper assembly bottles. May we request an
additional quantity of 100 bottles and 50 of placebo? It
would also be useful to have twenty of the pint bottles of
active Prolixin made available.
Because of a

Based on our initial experience, we should be able
judge our use more accurately.
Thank you

for your cooPeretion.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

to

�</text>
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                    <text>November 7, l969

Dr. Robert A. Buchanan

Parkeabavis Research Laboratories

2800 Plymouth Road

Ann

Arbor, Michigan 48106

Dear Dr. Buchanan:

Enclosed is a protocol approved by the apprOpriate
committees of the College for the development of a psychopharmacology study in childhood and adolescent behavior

disorders. Zarontin (ethosuxinide) is one of the compounds
that we are interested in testing in our initial studies.
Because of a desire to assure the delivery of medication
to our patients, we are making every effort to provide the
medications in liquid vehicle or concentrate form. In checking
the PDR I note that Zarontin is not clinically available in
concentrate form. In the event that such a concentrate is
available for experimental purposes, we would request an
Opportunity to test

it.

If not, we would consider its trial in capsule form
and would request your support of this study in making
available supplies of Zarontin and its placebo. Would it
be possible to provide us with 12 bottles, 100 capsules
each, of Zarontin and 6 bottlestf placebo? If a liquid
preparation is possible, I would like an opportunity to
discuss

its

study.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>November

7,

1969

Dr. Allen P. Berger
Chas. Pfizer 6 Co.
Groton, Connecticut 05340
Dear Allen,
As

I discussed, we are undertaking a study of various

in childhood disorders. For the reasons described
in the protocol, which is enclosed, we desire to provide
medication in liquid vehicle wherever possible. Our preliminary
compounds

.

study of Nevane (thiothixene) in concentrate form assures
of its activity.

me

necessity of filing an IND or any other
FDA
like to request supplies of thiothixene
concentrate 5 mg/ml sufficient to begin this study. May I
ask for 50 of the 30 m1 bottles with eye dropper and
15 placebo to start?
Thank you for your cooperation. My best regards.
Even with the
forms, I would

__.

Sincerely yours,

-,

.
.
A.

.1.

.N.

.2...“

-m.v-

w

.:.

n:‘-Iwrnr

:r-n-au—

fur-.7

”w-

"‘W““Wl“§'f

ﬂex Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>November 7, 1969

Dr. Edgar Grunueldt
Geigy Pharmaceuticals

Ardsley,

New York

Deer Ed,

Enclosed please find a protocol of our proposed child
psychopharmacology study progrlm. This study is designed to
give us experience in studying drug treatments in children
and adolescents so that in the future we may be able to

assess

new compounds.

described in the protocol, we are anxious to provide
medication in liquid vehicle. At this time I would request
your assistance in making available to us imipramine in
liquid vehicle, both 25 mg and 10 mg/toaspoon. If 4 oz.
bottles are available may we have a dozen of each.
As

this

In addition,

compound?
My

may

I request 12

bottles of placebo for

best regards.
Sincerely yours,
Fink, ﬁ.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>November 7, 1969

Fritz Freyhan

Dr.

St. Vincents Hospital
153 West 11th

York,

New

Dear

New

Street

York 10011

Fritz,
Please sign the card

two account
my

office.
Many

on

the

first line

statements,as President,

and

and the
them to

return

thanks.
Sincerely yours,
Max

Fink,

Secretary

MF:kp

M.D.

�</text>
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                    <text>November

7,

1969

J. H. H. Nieboer
Accts. Department
Excerpta Iedica Foundation
119-123 Herengracht

Mr.

Amsterdam, The Netherlands
Dear Mr. Nieboer:
I have looked into the invoice that you requested
in your letter of October 30. Please be advised that
the above invoice was paidoon February 20, 1969, our
check #29490. The check was in the amount of $1,315 and
covered items in the amount of $1180, $20 and $115.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                  <elementText elementTextId="103172">
                    <text>November

7.

1969

Dr. Allen P. Berger
Chas. Pfizer 5 Co.
Groton, Connecticut 06340
Dear Allen.

the

year trial of doxepin (Sinequan) in the clinical units.
representative
If agreeable to you, would you either ask yourMrs.
Cruzado,
the
pharmacist,
available
to
to make supplies
500
would
I
capsules
suggest
them
office.
my
to
or deliver
50
and
25
mg to start.
each of

a

W'wtﬂwmm

At the suggestion of my associates, I have requested
Formulary Committee of Metropolitan Hospital to allow

1

comparison
report of our doxepin - cllordiaaepoxide
EEG
data is
The
doxepin
and
in
final typing.
is
is complete
be
Both
available
will
draft.
and
in
is
its initial
complete
for distribution to our staff by the year's end.
The

’m‘v

tr
Yam

:

Sincerely yours,

72am”

.7."

an?"

-,
v.

iu'r'

Fink, ELLE).
Professor of Psychiatry

Max

qup-

L‘Astz'lrurv-nnvu

MF:kp
'WWIKMW»

1?
"7

1
‘

’

‘3’?”‘9‘1"!

9'“
.5?

�</text>
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                    <text>3=/
T0:

Alfred

FROM:

Max

SUBJECT:

Zelson Proposal

M.

Fink,

Freedman, M.D.

‘

DATE:

November 7, 1969

M.D.

I have read the proposal and can understand the Review
Committee's comments. The proposal is unfocussed; the ideas
too general; and dependence on outsiders to do ”their thing”
prominent. The staff has experience with opiate dependent
mothers and infants and the proposal appears to have been
formed by the buckshot method - try everything that sounds

sood.

is to help them. The focus is
therapy but on diffuse biochemical effects in infants.
Why these tests were selected is not clear.
Perhaps they
should be encouraged to focus their interest, explain their
foci, and this would be useful in defining a new protocol.

not
warm

my;

1‘1:qu

I

on

-‘"‘NI“§"7-qw

recent relevant publication

most

Mr. Rich

and

&lt;.

(
'w

4mmv—W1-u-r

‘

Jpnﬂi'ﬁm};

Mszp

...).

his

is the statistician of the Department of Pediatrics

is held in

"um"

vwwm».

1930 and lists as
1957 (1952, 1948

Asides: Dr. Zelson graduated in

“awfuyam

.

do not know how one

good

repute by

Don.

�</text>
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                    <text>November 7, 1969

Dr. Robert A. Turner

Consulting Pharmacologist
289 Greenwich Avenue

Greenwich, Connecticut 06830
Dear Dr. Turner:

for your letter regarding the

EEG changes during
Enclosed are reprints of
our clinical studies; and a pro-print of our latest report on
the EEG effects of heroin and naloxone as submitted for

Thank you

a cycle of opiate addiction in

man.

publication.

of greatest need in opiate addiction is an
antagonist of long duration of action (24 hours minimal,
7-14 days optimal), of high potency, with minimal secondary
effects, and without dependence potential. Cyclazocine is
potent and of long duration but the secondary effects so
common as to preclude general usage. Naloxone is potent and
without secondary effects but its duration on oral use too
short. We would like to see a long acting analog or form of
naloxone for clinical trial.
The drugs

specific question is difficult to answer categorically.
Subjects taking opiates during the development of dependence
show EEG changes from their baseline record. When dependence
is established, the BBC shows a characteristic highly synchronized,
alpha dominant record. As withdrawal is instituted, the record
is upset and slow waves, irregular patterns and fast frequencies
become prominent
only to have the record return to the alpha
dominant record with an opiate.
Your

—

If the opiate dependence is relieved, a more "normal”
record will assume prominence this may be of any type, and
should be distinguishable from the addicted record, in most
—

instances.

�Dr. Turner

—2-

November

There is, however. no single characteristic "drug" record
and "clean" record, and the difforoncos are to be found in

comparative or sequential recording.
Thank you

fbr your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

7,

1969

�</text>
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                  <elementText elementTextId="103175">
                    <text>November

5,

1969

Dr. George Gardos
Boston State hospital

Boston, Massachusetts 02124

Dear Dr. Gerdos:
I have read your preposal ”Perceptual-Cognitive Training
High and Low Dose Thiothixene"
with interest. It is an unbitious study and our laboratory
is pleased to cooperate. The use of the Branch and Kornetsky

of Chronic SchizOphrenics under

data in conjunction with the EEG changes may give us some
important information on the relation of EEG and behavior.
The following comments are meant to elaborate the EEG

details.

range. This is too broad, and if possible should
The EEG changes are different in young
and old people. If ago is not controllable, perhaps years of
prior drug use should be a factor in the assignment.
1.

Age

2.

Medication

3.

During the placebo period, on

be narrowed to 25-45.

to assure intake.—

may

be given in liquid vehicle or concentrate
BBQ

discarded.

The second

should be done and

placebo record will be the baseline record.

Records should be attempted
4-7 days, 1,2 and 3 months.

Leads:

at time of

CPT

testing:

left occipital vertex
left frontal - occipital
left ant.-temporal ~ vertex
—

bifrontal

needle preferred

Electrodes:
Recording:

15

minutes eyes-closed.

180 seconds

5

hyperventilation

minutes post hyperventilation

�-2-

Dr. Gardos

4.

The use

1969

of amytal as a night-time sedative is a problem.

If necessary, recordings

should be delayed 48 hours

after

a

Perhaps, chloral hydrate, paralydehyde, or methyprylon
be as useful (and productive of less EEG beta activity).

barbiturate.
may

5,

November

5. Analysis will be of 20 second epochs for
pre~drug and 4 post-intervals.

2

leads,

statistical analyses, will

measure the low and high
course of change, and adaptation (if any).

The

dose drug effect,
It should be possible to rank the subjects for degree of
change. The data may allow a measure of change in slow (1-7 cps),
alpha, and fast (13—25 cps) frequencies to relate to the CPT and

tests.

other

invited to visit Boston on January 15, 1970,
that time. The details of
tape recording, amplitudes, calibration signals, etc. can be
discussed then, and I would like to see a calibration tape
I have been

and I can see the laboratory at

tested.

made and

If

funds

it

may

be requested from NIHH or Roerig

for this

be advisable to include a budget for analyses,
and I can discuss that with you in January.

study,

after

We

my

The

may

can arrange

visit to

for

Miss Logourtz

Boston.

abstract for the

GIMP

to

work

will be sent to

Chairman of the Program Committee.

in

my

laboratory

Dr. Vinar,

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

P.S.

associate, Dr. Shapiro, reminds me that a task to insure
average level of alertness during the EEG
recording is
no
"hgzzzziyghewgugggogmgnd the use of a simple auditory signal
c
scones
This will not i ntlrfere
with drug induced effects and drowsy.
minimise the eve .0
effects of sleep. A simple device will be shes: wgring
y u on
your next visit.
:iny

.

�</text>
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:wn‘r‘ w—wuwr-Mu'ww"r'\ﬁ._'.~'v

~

"¢i\y~

Y

u.

.ww

u. ~.'nww«v—,- .mp1..-«,;w,,m-rsr.v~g.w,...,.,.Vin.

,,

November 5, 1969

Dr. Roger P. Maickel, Ph.D.
Professor of Pharmacology

Indiana University

Medical Sciences Program

Hall,

Myers

Room 360

Bloomington. Indiana 47401

Dear Dr. Molokai:
as a

for your invitation to articipnto
of
the new journal Mouton anmacology
editor
consulting

Thank you ﬁery much

and PAychophanmacaﬁogy.
The only

potentially suitabla manuscript

on my desk now

is enclosed. ”Electrographic Effects of Diacetylmorphino
(Heroin) and Naloxone in Man" was originally prepared for the
Bnizébh Jouhnat 05 Addictionb, but I would be pleased to have
appear in a new journal. The subject of heroin addiction
it
and its treatment with naloxone is an important research issue
today and we would like to have this material appear within
a reasonable time. May I ask that have your decision
within six weeks?

t

Again,

my

thanks for your kind

invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
CDC.

..

�</text>
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                    <text>November

5,

1969

Dr. Leon Eisenberg
Harvard Medical School

Chief of Psychiatry

Massachusetts General Hospital
Boston, Massachusetts 02114
Dear Lﬁon,
I am pleased to accept the invitation to join the
membership of the Psychiatric Research Society and am
grateful to A1 Freedman for his kind recommendation.
I look fcrward to joining you in LaJolla.

Sincerely yours,

,...

-'.rw'r,1-I;-v.—_-fvm‘,4

Max
"W,

1'
nr

rum-W

&lt;‘:rw:-

wamn-rn-wwmrwn

_7

‘

v;,.A_‘,....A.wr,,,w,v."

W”"m"WWLVWMVmW¢;-&gt;j

Fink,

M.D.

Professor of Psychiatry

wan-r

Jszp

�</text>
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                    <text>November

5,

1969

Dr. Alain Sanseigne
E. R. Squibb and Sons
Georges Road
New

Brunswick,

New

Jersey 08903

Dear Alain,

grateful for your kind assistance last week.
The study is now under way and I will submit protocols to the
idea, that
investigators you suggested. It is an intriguing
and
that we
I
hope
of a child psychopharmacology study unit,
will learn something new in the process.
I have continued to recommend Prolixin Enanthate in
problem cases and now have two patients who have required
more than doc/week for maintenance. Perhaps these higher
dosages, tested in Europe, should be made more commonly
known to the psychiatrists in this country.
I

am

most

Again,

my

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>November

4,

1969

Dr. S. Clyde Strickland

Merch Sharpe 8 Dohme
West Point, Pennsylvania 19486

Dear Clyde,

Since 1966 we have been active in assessing various
treatments in Opiate dependence. Rather than relying on
clinical criteria alone, we have developed the technique
of progressive heroin challenges to determine the duration
of methadone, cyclazocine, naloxone, and now centrophenoxine
in treatment.
At the recent methadone conference I was reminded by
Paul Blachly (Portland) and Jerome Jeffe (Chicago) that a
long acting form of methadone has been resurrected from

laboratory shelves for clinical trial. They suggested that
may make new supplies of the active forms of e long~
acting methadone available for study.

nerck

Our recent studies indicate that presently available
methadone is effective against 25 mg intravenous heroin

(-

$15~25

be of

When

street heroin) for

hours.

such compounds are available for

interest to test

My

60

them in

this

model.

trial, it

would

best regaras.
Sincerely yours,
nax Fink, M.D.

Professor of Psychiatry

MF:kp

cc:
3110.

A. M.

Freedman

�</text>
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                    <text>November 3, 1969

Dr. Ralph Jacobson
ENDO

1000

Laboratories
Stewart Avenue

Garden

City,

New

York 11530

Dear Ralph,

to confirm the telephone conversation of October 27.
You will be pleased to know that Dr. Zaks has been successful in
extending the duration of antagonism to heroin by naloxone. In
a subject receiving 3 Gus/day, 26 mg heroin, 25 hours after the
previous dose was experienced as a "blank", the subject exhibited
neither behavioral, physiological or EEG signs of heroin administration.
I wish

Dr. Zaks was planning

to retest the subject at

50 and

perhaps at 75 mg (at 24 hours). This experience is very
encouraging and I have asked Arthur to send you a detailed
summary and a plan for continued study as soon as he completed

the present series of experiments.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>.4
P».

rP‘4‘W-‘vvp'

...,

74""

n.

November

3,

1969

Mrs. Anna E. Sorrell
Grants and Contracts Management Branch

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Mrs.

Sorrell:

RE:

5 R10

MH

13358-03

for your letter of October 24, extending
year to 3/31/70 and the project period to 3/31/71.
With this approval, I assume the application for continuation
support will not be due until February 1, 1970, rather than
November 1, 1969. I plan to submit the completed application
for continuation in hid-January. If incorrect, please advise.
the

~03

Thank you

Sincerely yours,
Fink, 340DProfessor of Psychiatry

MEX

MF:kp

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                    <text>November 3, 1969

Dr. Nathan S. Kline
Rockland State Hospital

Orangeburg,

New York 10962

Dear Nate,

If the program at the AER? in February allows, I would
like to present a report of our EEG studies in normal volunteers
co—chalrmen.

in the committee of which you and Dr. Evans are

Two years ago the date with major psychoactive drugs
presented. Since that time I have expanded the method
to assay new psychoactive drugs and I now have some unusually

was

fine date.
”EEG

The

If an opportunity is made available the
Profile Analysis of Psychoectlve Drugs in

authors are
My

Max

Fink,

M.D. and D. M.

title

Shapiro, D.Sc.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MFtkp

should be

Normal Volunteers“.

�</text>
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                    <text>January 31, 1970
Dr. Seymour Katy

Professor of Psychiatry

Harvard Medical School
Boston, ﬁassachuaetts Oleé
Dear 8y,
The meetings were excallent in Aspen, and I very much
enjoyed your presentation of catechol amines and memory function.
I In writing to requast a copy of the paper, so that my associates
and I can hava the luxury at reading 1c in detail and digesting

v'

ur-

'
"W

"inwwnm'mlw’xw

”mu-r

J.’
A:

the material at leisure.

Perhaps there is an occasion vhnn some of the students
of tha convulsive therapy prunes: can get together to discuss these

new

findings.

w“

I look forward to seeing

-muwr

you

at the

APPA.

_

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

.

~

r
wanna"

nag,

mm.

‘uu;..;lﬁ»"/'M"H

4-;

um?»

rw‘ww-

mam

-;vm

�</text>
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                    <text>January 31, 1970

Prof.

C. A.

saleuink

Department of Grgnnic Chemistry

University at Utrecht
Utrecht; ﬁcllané
Dent Yrof. Salamink,

to vial: my laboratary ané $hare your
expuxienC&amp;s with cannabig with us. I ragret that yvur viait was so
short, and trust thﬁt we will have a mere extanded apportuzity 1n
the near future. 1 have bean inﬁormeé that there may be a conferance
on ennnabia in NQW York later this yaar, ané I hava taken the
liberty 6f suggeatimg your mama as ena of the participants.

It

was him&amp; of you

During yam: visit, you nauticaed the posaibility of supplying
marijuana and haghigh of kncwn strangth for our studiea. I wnuld
ha pleased to take advantage of your offer, ané in axchange, sead
you copiae oﬁ our finding&amp; as amen as shay are available. We have
a limited supply 9f marijuana and the bathtub is of avnragc quality.
Ha would like to undertake systematic studies in about 38 subjactg,
2 trials each, using the equivalent af 1 Ga. mariju&amp;na each experimant,
for a total of 60 grams (marijuana) 0r aquivalenz in hashinh.

available

I would be grateful for yout sdvica as
£nd how
is to be shippad.

it

Many

ta what

may

be

thanku.

Sincerely yours.
Fink. M.D.
Profeasor of Psychiatry

Max

mf/

�</text>
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                    <text>tram" —_‘—w‘~m-~ww~—n77,_.wy

7‘

.,.

~

v...“

777——

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.

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I‘VlﬂwT-Vdnm-Wu'nwu

.,

w-

mlm'mv

7

January 23,

‘vg‘w’uwxl

1970

m

Strickland

Dr. S. Clyde

Merck Sharp
West Point,

&amp;

Bohme

Research Loboratories

Pennsylvania

19486

Dear Clyde,

ﬁnclosod is a protocol of a proposed study ”£-o~Acetylmethadol
as a Maintenance Treatment of Opiate Dependence”.
This protocol has been presented to the sopropriato committees
New York Medical College for approval and we will be able to
undortako the study whenever supplies are available. I am enclosing
a copy of my curriculum vitae and will sign a 1523.

of the

My estimate of an initial supply based on five subjects x
ten weeks is 10 Grams. If the supply is adequate, 20 Grams will
allow us to continue over a longer period or ten patients for
ten woeks.

Thank you very much

this study.

for your cooperation

and I look forward

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Ml?

:kp

one.

to

.

7

�</text>
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                    <text>We”:

WWW-mvh

W—»r-Wm—v

mtw“'

,7 . “v Iw'le-val w

mmwmw"

uvﬂt'w‘.

n
—

January 22,

1970

Mr. Seymour Weingarten

Plenum Press
114

New

Fifth

York,

'

Avenue

New York 10011

Dear Mr. Weingarten:
Thank you very much for lunch. Enclosed is the APPA
Program. I trust we can get together during the meetings.

Sincerely yours,
Fink, 34.0.
Professor of Psychiatry

Max

Mlzkp

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                  <elementText elementTextId="103186">
                    <text>January 22,
Dr. H.

1970

Billing

Facharzt f. Neurologie u. Psychiatrie
Max Planck Institut for Psychiatric

Kraepellnstrasse
8

2

nod 10

Mﬁnchen 23, Germany

Sehr geehrter Dr. Billing:
Boer Brief ln welchen Sie nachfragen ﬁber Cannabis-Psychosen
sehr lnterresant, hauntsachlich dos Haschisch wird jotzt in
Burcpa mehr gebraucht, so wie in Amerikn. Es ist mlr unbekannt
von den anderen Nachforschungen von Haschisch, aber ich sende
euch das material welches wir hier hahon wegen diesen Problem.

was

Hnsere Naehforschungen begrenzen etch an akute Experimenten
mit marijuana and THC so dass wir das EEG Bild untersuchen konnen.
In der letzten Zeiten haben wir das Studium von chronischen marijuana
Effekten angefangen, aber unsere Ergebnisse 51nd noch sehr karg,
und wir habon noch nicht unsero Findungen publiziert.
Ich habe Ihre erste Frage ﬁber die Europaischer Spezialisten
mit Herrn professor Alfred Freedman hesprochen, aber weder er noch
ich 31nd fahig Ihnen eine positive Antwort zu geben. Das Problem
der Hasehlsch-Psyehosen wﬁrde von elnigen Amerlkanischer Arbeiter
studiert, zum Beispiel Professor Freedman (New York Medical
College), Dr. M. Keeler (New York Medical College), Professor
D. X. Freedman (University of Chicago, Illinois), und Dr. L. Hollister
(V. A. Hospital, Palo Alto, California). Ich bin sicher dass elner
von diesen Herren gerne Euro Frage beantworten wﬁrde and auch an
Euro Tagung anschllessen wﬁrde.

hat mich gefreut dass Ihr Each an uns gewendet heben, und
Sie frei sich wieder an uns zu wenden wenn Sie andere
fablen
bitte
haben
wir persdnlich antworten kennten. Unsere Crﬁsse an
die
Frags
Herr Professor Herz.
Es

'

mlt freundliche Cmsse verbleibe Ich,

Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 22,
Dr. Alfred

M.

1970

Freedman

Department of Psychiatry
Now York Medical College
5 East IOan Streot
New

York, New York 10029

Dear A1,

its

The Research Committee at
meeting today was unwilling
an alternate for my membership on the
committee. I withdraw the suggestion.

to accopt the concept of
I

find that

I am unable

to attend the meetings of the

ResoarCh Committee with sufficient frequency to be a useful
participant and ask your permission to resign.
I would commend Dr. Stanley Foldstein, Associate Professor
of Psychiatry, to your attention as a suitable substitute.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

”szp
cc: Dr. Lohr

�</text>
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                    <text>January
Dr. Wayne

53.

22 , 197!)

Jostrmd

Marketing Roprosontntlvo
Data Processing Division
475 Northern Blvd.
Great Rock, New York new
ﬂoor

Wayne ,

For three years we have been renting an In”. 1890,
assembled at 5 East 1023:! Stroet, under your Invoice 330. #287722.
This equipment was paid for by a grant award from the National
Institutes of Mental Health to the New York Medical College.
This award expires March 31, 1971.
I“'«7;»'4aaaj~mm'«wrn=m‘m¢~wK

NW

‘

.

In order to continue support, we must apply before Juno 1,
We wish to purchase the equipment listed on our invoice,
1970.
now installed at this location on Avril 1, 1971. Would you please
obtain a quotation for purchase on that date?
We

will also

ask

for a quotation of the charges for maintenance
April 1, 1971, so that

of the equipment on an annual basis, offectivo
we can make the necessary applications.

Sincerely yours ,
Max

Pink, 54.3.

Professor of Psychiatry

M? :kp

�</text>
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                  <elementText elementTextId="105812">
                    <text>January 22,

1970

Dr. Doris H. Clouet

Associate Research Scientist
New

State Research Institute for
Neurochemistry and Drug Addiction

York

Ward's

Island,

New

York 10035

Dear Doris,

Enclosed are copies of the two reports which
submitting for publication in your volume.

we

are

The reference to Wikler 1965 should be deleted from
the electrophysiological report.
The quotation of Lewin was originally published in 1942
German.
In 1964 his work was translated and published by
Button and Co. and
is that edition from which the quotation
I
believe the quotation an appropriate frontispiece
is taken.
and would be pleased to have
heed the article. The way in
which the 1942—1964 discrepancy can be justified would be by
adding at the foot of the frontispiece: Lewin, 1942 (translated,

in

it

it

mm”,

'a'ww‘rn

1964).

Thank you

“Myrrh-Hr

my

for your kind statements about the articles

best regards.

w-wwarwxv

Sincerely yours,
“no"

,.

Max

Fink,

M.D.

Professor of Psychiatry

HF:kp

:‘vrnvw

A
&lt;

u

it?!“

and

�</text>
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              <elementText elementTextId="41773">
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              <elementText elementTextId="91501">
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                <elementTextContainer>
                  <elementText elementTextId="103189">
                    <text>January 20, 1970

&lt;
.
v,
a

”at

’&gt;"IV.u—&gt;r"'

.vr

:u-.-

q.

,-

.Avﬂesnmnmm

rt"

71

an
an
w‘...

1..-

V-zr

shim

-.-=.~.

Dr. Allen P. Borgor
Chas. Pfizer &amp; Co., Inc.
Groton , Connecticut
Dear Allen.

is a revised protocol of the EEC « thlothixene
concentrate and capsule study. You may recall that in the
first definitive study we misjudged the time of onset as
Enclosed

well as the dosage.

Based on this experience, we have retlsod tho study
which now is in progress and is approximately one~quartor

completed.

Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

HF

:kp

�</text>
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m.

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"va“.

January 19,
Mr. Robert

w_m_-»-- w._;_r~.WW. "tn“...

1970

Harlin

Sande: Pharmaceuticals
Hanover, New Jersey

Bear Bob,
Dr. Rothwell

DeceMber 22, 1969

called to discuss our interim report dated
of S~421548.

His criticism was well founded. I
of enclosing a revised page 8 and 9. I
you would remove page 8 from the report
to me or destroy it.

am

taking the liberty

would be grateful
and either return

Sinceraly yours,
Pink, %.D.
Professor of Psychiatry

Max

MF:kp

one.

if
it

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..._-u.p.4.mw 1w-1-wm‘171w‘nrlm»-nm‘w-w—w—-Iwmn3w"r~"*

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January 19,

—.

M..-

1970

av..-

:vrr

Fr:~‘"w','v'l:KV4—-.‘mvrr-yulvm

Keup, President
Eastern Psychiatric Research Association, Inc.
Dr.

W.

681 Clarkson Avenue
Brooklyn, New York 11203

Dear Dr. Keup:
WWI'met-Wntvn-o»

sending 170 copies of the program of the
grateful if you would ask a member of your
them
staff to mail
to your members. We will, of course, pay
and
for postage
his or her time.

APPA.

Separately I
I would be

am

I look forward
EPRA program

of the

Many

to reciprocating
to our members.

and sending the announcement

thanks for your cooperation.

Sincerely yours,
Pink,
Secretary

Me:
FéF

:kp

M.D.

.- 7......

.

“.7”,

.,. ._

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                    <text>January 19, 1970
Dr. Allen P. Berger

Associate Director
Chas.

Pfizer

&amp;

80., Inc.

Groton, Connecticut 06540
Dear Allen,
I will be pleased to participate in the meeting at
Kings Park State Hospital on February 4. In the event
that it will be difficult for mo, I will ask one of my

associates
My

who knows our work

thanks for the

to attend.

invitation.
Sincerely yours,

a!” Fink,

MJJ.

Professor of Psychiatry

Mﬁzkp

-'y
r.
V

_

'

5RX"“'

«aw-r

‘1'2~"'.r.~"1‘

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W”

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                    <text>r.—m-m-m-~1n.

January 19,

1970

Dr. Allen P. Berger
Chas. Pfizer E Co.
Groton , Conno ct i cut
Dear Allen,

Enclosed are three copies of the final report of our
study of doxepin and chlordiazepoxide in anxious outpatients.
This report has been sent to Cuttcnt Thehapeut£c Rebeanch
for their consideration.

Separately, I will send a more complete final report,
and copies of the various rating scales used in the study.
Earlier, you obtained a copy of the statistical analyses

of the Biometric Laboratory.
Again,

study.

my

thanks for your cooperation during

this extended

Sincerely yours,
Wax

Fink,

M.D.

Professor of Psychiatry

Hﬁzkp

enc.

�</text>
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NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
TO-

FROM'

°
Dr. Jack L. Rub1ns

Max

Fink,

DATE

_,

‘

ALB.

0
1/1J/70

SUBJECT

Are you aware

that

5-day

13

is the

week

of the

APA?

Unfortunately, I am scheduled to give a lecture in
Westchester on *an 20. ‘Iay I suggest that you schedule these
two

HF

lectures for

:kn

May 27

and June 3.

�</text>
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                    <text>,.

v.,-

wq‘mr

.

,

WM

.-

an.»

V

m.,—ywru.m n.1—WW‘
,

'Wwwvv _..Nwmu—»m..__~w

January 16,

7......m—m .,.,

1970

Dr . David Lohr

Dcpartmont of Pharmacology
Now
New

York Medical College
York, New York

Dear Dr. Lehr:
While I very much enjoy

my

membership on the Resourch

Committce, I find it difficult to attend tho scheduled
meetings with sufficient regularity to be an active
participant. In discussing this problem with Dr. Freedman.
I suggested, and he concurrod in asking you to appoint an
alternate from our Bapartmont.
We would recommend Dr. Arthur Zaks as alternate to the
Committee on Human Research; and Dr. Richard Abrams. to the
parent committee. If you agree, I will continue to attend
whenever possible, asking the alternates to accompany me when
they can, and to replace me when I cannot.

If this

recommendation

for altornate suggostions.

is unacceptable,

I would be

Sincerely yours.

Professor of Psychiatry
MF:kp

grateful

�</text>
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                    <text>F'"‘“"w‘""W-Wv—— v—v—m w‘

-

-

hr-VM'H—

WV“ wrwv.~—~—- ..,..,‘r..,~‘—-W.‘Wm

7.4

w.—vy-—mv-v.—.W._w ”mam—w... ..‘..w-~...‘

.77..

y

.w.“

m.

,

.

-

«mun-w

ww'

January 16,

1970

Dr. Allen D. Burger
Chas. Pfizer % Co.
Groton , Connocti cut
Dear Allen,

is

interim report dated January 4, 1970
of the first ohaso of the EEG profile analysis of C? 14.368.
The report summarizes our observations and concludes with a
reCOmmendation that we use 250 mg as the single dose for
the phase two studios.
ﬁnclosed

an

list

of oxperiuonts
sheets
for the
and subjects, I am enclosing the actual data
be
These
useful to any other
behavioral observations.
may
investigators who may be interested in the effocts of CP 14,568
in normal volunteers. I am also enclosing summary work sheets,
insofar as these may be of interest.
In addition to the summaries and the

Two

additional copies of the

distribution.

summary

are enclosed for

The phase two study has begun and should be completed

within four months.
Thank you

for your cooperation.
Sincerely yourg,

.

1

Mszp
0116-.

ﬂax Fink, H.D.

Professor of Psychiatry

�</text>
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v..—:.m-..:-,--

~»

.uwamm-sdew-was.“ .m "mm... memmmnﬂu...

.—.. mar ..V,_ w“...-

mu

“.v‘

V.....,.wm....

...~.....,... NV.- 1..., ..

w ...

January 15, 1970
Dr. Robert Kokoski
Spring Grove State Hospital
Baltimore, Maryland
Dear Dr. Kokoski:

Recently I was discussing the problem of the measurement
of chemical substances with Al Kurland. He reminded me that
you are running a quantitative laboratory and offered your
services when I had a special problem.

is

a sample which may contain an Opiate and/or
barbiturate.
grateful for a qualitative assay.
be made of an opiate substance,
can
If a quantitative assay
I would be grateful.

Enclosed

We

I would be

will, of course, defray

be incurred.

any costs and charges which may

Thank you very much

for your services.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFPkp

..

.....

.

_

_

, .7

,

,

»

a

�</text>
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                    <text>~

.A

m

*1

W'Iﬂ‘w'mw'mv

.v

|"

..:-

ww‘

,‘W~y~&lt;-VV

v
xan:

«mm—mu

«PW:

'v—xuwll

..

‘

va‘ﬂyw-I

-quwﬂf'w1~

mm

tun-var

.r—Ir

/

wn-n.-,,_-._~"1....

Huron-AW“,

mu “w..."

.Vuvwr. “air...”

w.

.......

.V...

,

"V‘erm‘.

,

1970

Psychiatrische Universitatsklinik Basel

Wilhelm-Klein~5trasse 27
4056

Basel, Switzerland

Dear Dr. Kielholz:

Before the holidays I sent the enclosed suggestions
regarding the CINP program. As I have not heard from you
I am taking the liberty of sending you a copy of that letter
and ask

for your

comments.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

,M—

”a...“

.

Dr. P. Kielholz

..,..

va,n.~_q,-w..¢.r

at: “Hum“ m"".~gw—-MMIK&gt;W‘A-—.‘ .nw—«M -,,

January 15,

«Vinwnﬂngnw

4,...V

»

6116.

�</text>
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                    <text>«v.-

1:
oz:-

Wm

t5"

saw-wave

«w

vmmpa'u'wl

January 14, 1970
Dr. Roger P. ﬁnickel, Ph.B.

Professor of Phsrmacology
Indiana University

Meéical Sciences Program

Hall,

Myers

Room 360

Bloomington, Indiana 47401

Dear 9r. Maickel:

sent a copy cf ”Electrographic
Effects of Diacetylmorphine (Heroin) and Haloxone in Man"
for your consideration for the new journal ﬁgggppharmacq}ggx
0n November 5, 1969 we

and Psychopharmacolqu.

must be very difficult to liunch a new journal.
Nevertheless, we would like to ask whether this manuscript

It

is acceptable or whather
Thank you again

we

should submit

it

elsewhere.

for your invitation.
Sincarely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kp

�</text>
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                    <text>w—-w«

-

January 13, 1970
Dr. H. C. B. Denber

\.

Manhattan State Heepltal
Ward's Island
New

York, New York 10035

Dear Hy,

Enclosed are two copies of the report "Laterallzed

Changes

after Unilateral

and

Therapy” for inclusion in the

Bilateral Electroconvulsive
GWAN.

Sincerely yours,
Pink, “.9.
Professor of PsyChlatry

Max

Mszp

EEG

�</text>
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                    <text>January 13,
Dr.

Peter

1970

Kellaway

Baylor University College of Medicine
1200 M.D. Anderson Blvd.

Houston , Texas
Dear

Peter,

Enclosed is an abstract,”Lateralized EEC Changes after
Induced Convulsions,” of our presentation before the EAEEC
of 1969. The abstract sent prior to the meeting contains a
few errors wlich have been corrected in this draft. If the
abstracts of that meeting are to be published, would you
please use the enclosed as the text?
Thank you very much.

My

best regards.

"an?!

Sincerely yours,

.

Fink, 3.0.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>January 10, 1970
Dr. Wolfram Keup

EPRA

681 Clarkson Avenue
York, N.Y.

Raw

Dear Dr. Kaup,

It will be a pleasure, to have the abstract of my
ptesentatiau to the Hovembet meeting of EPRA, incluéed in tha
report of the proceedings, with the literatura citations.
I am taking the liberty of enclosing an announeamant of
the forthcoming meeting of the Amarican Psychopathological
Association, in Haw York on February 13~14. Since the subject
is can of intcrest to members of the EPRA, perhaps it may be
useful for us to circulate copies of the prograa to mambars;
or, at least, announce the meeting to those that may be interested.
If such circulation is possible, I will make copies a! the prograa

available.
EPEA,

I look forward t0 participating in the

and thank you

for the invitation.

activities of

gincarely years,
Max

Fink,

14.9.

?refesaur of Psychiatry

mf/

�</text>
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                    <text>January 10,

1970

Editor, Calendar
SCIENCE

1515

Massachusetts Ave.

Dear

Sir:

Washington, D.C.

we wanid appreciate inclusion in the calendar of
a record of the next meeting of the American Psychopathological
Association, in ﬁaw York am February 13«lé, at the an York
Eilton Hotel, on the subject of " Mona Discréers“. Requests

for information are to be directed to the Secrataty,
at 5 East 102 Straet, New York City.

Max

Thank you.

Sincerely yours,
Ha: Fink, H.D.

Secretary

Finka M.D.,

�</text>
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E

i
E

E

?
F
E

r
E

E

January 7,

1970

National Institute of Mental Health
5454 Wisconsin

Chevy Chase, Maryland

Gentlemen:
May we please have three sets of application fbrms for
Public Health Service Research Grants.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 7, 1970
Grass Instrument Co.
101 Old Colony Road

Quincy, Massachusetts
Dear Bob,

In order to provide for the play-back of some of our tapes
need, as soon as practicable, another Model 79 portable polygraph 9
particularly the chart drive, regulated power supply, oscillograph,(1),
I

and

signal marker.

I already own

For

a 7P5118.

until this

can be supplied.

me an approximate delivery date by phone.
come through the International Association.

checking and giving

The order
Many

will

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.v

.r—ynr

amplifier should be

this purpose, I would be willing to Obtain a used
if such is available. I would appreciate your

instrument

--

A-

The

I need this instrument as soon as practicable and if it can
be supplied sooner without the 7PSll, I can use one of the many

e—r

..-

Peterson

Mr. Robert

MF:kp

�</text>
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                    <text>rww'... ,,__, ﬁwm..m.~.r—

y.-_m.

.

'm'v"m'-«w

,

.m- ¢t"

'vrr

. ~

‘

n ‘u

v-uww_.....-—.w

..

_-

.

-

'vwwvw

wrm

--.——v-.. m“

Iw'w—V4w-K

-.r‘..—‘,...

V

.7... “K "W...— ....w........._.

van-w”.—

January 5, 1970

--:~

-

g

Dr. Wilfred Dorfman
1921 Newkirk Avonue

E

Brooklyn,

New

York 11226

l

Dear

I

Bill,

E

time ago you asked that I roviow the volume by
"Clinical
Wittenborn,
Psychopharnacology of Anxiety". I regret
do
for so long~~ I guess I repressed the
that I neglectod to
it volume
found
the
less interesting than many othera—~
project since I
found
and
time
the
the result 10 enclosed. If it
but I finally
still interests you, please use it. If not, perhaps you'll try
Some

r

another.

My

best.
Sincerely yours,

:

_

.

”HIW'PV'NW",&gt;'IW—nvr

1'

.

_,

mun-,-

,,

Max

Fink, H.D.

a..." m,..-—_.w...__rw.“-.. ...v v

�</text>
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                    <text>January 4, 1970
Dr. Allen P. Eorgar, M.B.
Associate Director
Pfizer Pharamceuticals
Grotoa Connecticut
Dear Allen,

Enclosed are tha

1573 for the study of thiothixene/
anxiaus suhjacts in the partial hospitalitation
program at our College. This atudy has met the ayproval of the
ralavnnt local cnmmittees and will be prasented to tha Resaarch
Coamittce at it: wanting later tits month. I believe the study
can begin as soon as the supplies art made available.

thioridazina/placebo

FD

1n

we will submit a
rtqutat for support for this study,
based on the anticipated completian cf 30
subjects before tha and
of the year, of $10,000, plus $3,000 for Sallega
overhead. In the
evant the study 13 not comglated, tbs suppctt will be negotiated.
Paymant 13 to be made at the and of the study.

Enclosed also are Farm

FD 1573 Gor the thiothixene
capsule
study in children and adalescants, following the protocol we submitted
soma aontha ago. It in my understanding that as seen
as it is
feasible, you will reconsidar the possibla use of thiothixane
1n
concentrate form in this study.

Many thanks for your coaparation, and
a successful 1970.

my

best wishes for

Sincerely yours,
‘

‘

'

c..d""

Max

.1231»

a
"
5'"

&lt;

w

awn

wrmumxe“

mlmpﬁwm

Fink, M.D.

Professor of Psychiatry

(“an

at]

�</text>
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                    <text>”I".

in

1

wnmmWw-v'm'mns

'3'"

W‘

--v

.1.

Mr.

ya!!!»

-r--

January 2, 1970
Dr. Oldrich Vinar
Psychiatric Rssearch Inatitute
Prague. Czachoolavakia
Dear 01d:1ch,,

Enelosaé la an abntraet far your consider-ting for the
fraa communicatians at the forthcoming SIN? mneting in Fraguc. I
think it would be upplicabla fer the communications in relation to
the symposium on ch: evaluation of ant1~anxiaty drugn.

I have not recaived a reply

as yet and so have an more to
My

report

ﬁram

Proteasor Kielholx

an the amphetamine sympenium.

best regatds.
Sinccrely yaurs,
Max

Fink,

M.D.

rrofesnot of Psychiatry

mil

�</text>
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                    <text>.. .

- two

...x..m~-...w—n;(—7....

~......—‘w,“..-W.—ww-vw,..,

.w

‘e'-‘

v"...

1,... ~....r~wu4-.r

...

.-

.

:

‘.

mmr-u

7W v.—.,_—vi,..,._.,~, ‘

V

,,..,_

1““!m'n-mevI-Iv‘r-"w-

A-

‘
v

&lt;

January 1, 1970

~w1;w.W1an-vwv

:I‘V'J-v

1.
«a

"wwwsmww.

Dr. F. A. Froyhan. M.D.
153 West 11

New
-

Dear

Street

York City

Fritz,

It

was kind of you to invite me to portioipato in the
District Branch program in March, and I vary ouch regret that
I will be in Denver during the neck of the noeting. I have discussed
the problem with A1 and he concurs in the recommendation of our
associate, Dr. Arthur Zakn to complement his presentation.

APA

Dr. Arthur Zak: is an Instructor in Psychiatry in the
Department. Since 1966, when he was a resident. he has been intimately
cosociatod with our studies of oyclazocinc, heroin, noloxonc and mathadono. He is fully acquainted with our data, add has attended the
rcccnt meetings of the HAS-NRC committee, no that he is fully
acquainted with the work of other investigators. (Incidentally, he
is also a yrincipcl in our studies of cannabis).

I underntcnd the proaontation in on March 12 at the
Academy of Hodicine. I will anoint him in the preparation of his
roport, and am confident that he will do a commendable job, in
doocrihing tho ptoocnt approaches to the treatmcnt of Opiate de~
pendonce and a vino of tho future. with particular emphasis on the
development of a long acting naioxonc.

‘A'W‘I'

.'
.m

.vww

.-

rwm-w,s.-;m:ywm

van-YT

mmxvm

.
1571909.

'7.)

an
.7:

“FHP'

veer.

”.31;

4'1

Im-

Incidentally, for the January prosontation (Halon), A1
recommends Dr. Myron Denholtz as a discussant. Dr. Denholtz has
been a student of Wolpo's and 13 an activn participant in our programs.
Sincerely yours,
ﬂax Pink, M.D.

�</text>
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                    <text>.w

«7.,wv..‘.m.¢

_,

.

V

._,..._

.

.‘._

—..,.,.,,

,.

.‘

fwwy

-._n_....i‘.

____

,

w. “in...

,..

,

.__.

M-

n

“77.7.“.7 V,“

7.

“no

.
‘rw-rw'

u.—

«.

"vn‘amr

January 1, 1970
Dr.

J.

Mondale, M.B., M.D.

Depression Research Unit

V.A.

hospital

University and Woodland Aves.
Philadelphia, Pa. 1910é
Deer Joe,

It was kind of you to invite my participation in your
volume, "Textbook of Biological Psychiatry", and I am pleased to accept.
An I read the list of prospective titles. I so surprised that you
see the EEG as a companion piece to the many biochemical essays planned
for the volume, and I hope that I will be able to accomplish the mission
in a satisfactory fashion.

I presume you wish an outline and you will not a reedonahle
deadline for the final manuscript.
You should know that I am working on e cimilar section for
the Textbook of Psychiatry, 2d edition by Freedman and Keplen. I have
diocuased your outline with Dr. Freedman, and we both agree that it is
possible to make the presentations sufficiently distinct as not to cause
either you or him any embarrassment.
My

m

best wishes for

a successful 1970.

-,
Lyra-

r"

Sincerely yours,

m-mvnumu'v

“If“?

Fink, M.D.
Professor of Psychiatry
Mex

:rpxmw'w.‘

No-

4:
I,"

mf/

9.9.

Would you be so kind as to post the enclosed announcemoot of the
1970 APPA meeting on some suitable bulletin board at your hospital ?
Bony thanks.

�</text>
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                    <text>"I'M

l

.

:‘rl‘auwlv"w'lwmrp‘.u~.x

www-

,

January 1, 1970
Br. ?.

J. Fell,

N.V. Qrganon

H.B.

035, Holland

Doar Dr.

Fell,

It woo kind of you to write about our interest in
computer analysis of tho EEG. Your miasion. as described in your
is a commendable one, and I will do my host to assist you.
mothods of

letter,

Thare is indeed much conflict about the value ofoortain
ascoasmont. The history of the problem is very clear.

EEG

Since almost all practitionorl of EEG analysts dopond exclusively on
visual analysis (done rapidly and profitably for clinical purposes),
there are very few who have taken the timo to do quantitative assessmonta.
Among the few who have used various quantitative methods, there in little
disagreement; for ouch of on will anawcr the qunstion about relativo

merits of each technique by asking, ”Merits for what purpose ?" Each of
the quantitativo techniques have been useful in some project. This is
true for analog power spectral density analysis or analog amplitude
integration or analog period analysis: and similarly. digital computer
methods for power, period and anplltudc; as well as digital mothoda
for sleep prints, shape analysis, averaging, etc.
In

questiona.

this framework, I will attempt to answer each of your

l.

The most sensitive oathod ? For what determination ? In
are able to distinguish small doses of psychoactive drugs
in volunteor human nubjocta using period unalyaio (320 samples/soc, 10 or
20 second epochs) or power soectrum (100 samples/second, 50 lags). We
have separated 50 and 100 mg anobarbital; 50 mg fenflurnmiue from 50
amobarbital and 10 dextro-amphotamino; ate.

our hands,

wo

digital computer programs era written for the IBM
K), disks (2) and a fast printer. Those are
available to qualified investigators approvoé by the ﬂlﬂﬁ agonoios
who oupportad our work; or at nominal coat to industry. However, I
would suggest that it is not the packngos that you need (although those
are helpful) as tho opportunity to work through town of the programs
with members of our staff, particularly if your machine is diffetont.
1800

with

16K

2. Our

(or

8

�_

”m“

a,

._V

r,
.t

dwl

.

uwxnmrmmn

“i;
d

l

\

PCJO

Fall-OOOOIIOOIIOOOOJanuary1, 1970 It...OOUOIOOOCOOOOOOIOOUI0.0.0.02

The programs can run on

the

IBM

360/40 with 1827 converter.

3. The various technicalities I mention in my article
small
technical tricks that we have learned, painfully
are the many
and expensively, over 13 years of effort, to tease out drug effects
from EEG records. The changes are there and when working with human
subjects we are aware that it is necessary to control the environment
for noise, alerting taska,, blood sugar, etc. These controls sound
formidable on paper and are very simple in practice.
A. The

“W‘

same

programs for sleep

conditions as the other programs.

prints are available

on the

recently been invited to consult with two other
pharmaceutical firms, one in the U.S. and one in Europe, who have
expressed similar interests to your own. We have found it helpful to
visit us.
suggest that a technical representative of your laboratory
and
attempt to
we will make our facility available for your inspection
make
decisions
the
allow
to
you
work through the questions that may
you seek. In the event that it is useful, one of my co~workero or I
could visit your laboratories, to describe the available processes,
We

have

particularly in the context of your interests
I trust those

your inquiry, and

my

comments

and needs.

are responsive.

Many

best wishes for a successful 1970

thanks for

!

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>{/fﬂr

\ﬁgﬁko‘;

X“,

Vabruary 28, 1970
Dr. William Ogle, M.D.

Street
Seattle, washington
1107 NE 45

Dear 3111,

It was kind to invite my participation in the
North Pacific nsyohiatric meetings in Vancouvor~~ and I would
have been honored to participate. I have been away at meetings
for more than three weeks, aad this is my firnt opportunity to
answer directly. My secretary tells me that the program is
completed, and I regret this. but thank you for the honor
of the invitation.
At the ACNP I mot Jerry and we discussed our mutual
friends. He is well, seems to heap an active interest in teaching
and research, and has maintained the leadership of the Psychiatric
Reaearch Society with Hy Bomber (who also was at the mooring
and is busy flying his own plane about tho country).

Again,

delighted to

My

my

visit

thanks for your thoughts~- and I would be

in the future.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Foychiatry

Max

�</text>
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A
\ng

February 28, 1970
Miss Janet Grono
Delphoo, Ohio
Dear Miss Grone,
Your letter to Dr. Taylor was sent to me for roply,
since Dr. Taylor is now in the military service an&amp; is unable
to continue his brilliant work. The war in Viet-Nam, which is
so destructive of lives, is also destructive of other good things
in our societyv~ including research.
The boat has already been published, and there have
boon no other studios. I hope that as soon as the military
releases Dr. Taylor, he will return to carry on this important

work.

Good luck

in your studies.
Sincerely yours,
Hot Pink, M.D.

Professor of Psychiatry

P.S. For a good discussion of schizophrenia, may I suggest you
request any textbook of psychiatry, particulariy the
Comprehensive Textbook of Psychiatry, edited by Freedman
and Kaplan, published by Williams &amp; Wilkins, 1968.

�</text>
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                    <text>February 28, 1970
Dr. William Drew

University cf Kentucky

Lexington, Kentucky
Dear Dr. Drew,
The

antidepressant paper is published in:

Pink, M., Simeon, J., Itil, T., and Freedman, A.N.: Clinical
Antidepressant Activity of Cyclanocinc~ A Narcotic Antagoniat.
Clin. Pharmacol. Therap.,_lg;élmé8, 1970.
Kaella and Karczmar citation is correct, ané the

articlc is chapter
The

52«71.

A, pp

preprint

activity of cyclazocine

on the

by

part of the article cited

EEG

identification of clinical antidepressant
criteria was not accepted anﬁ is

above (Clin. Pharmacol. Therap.)

Reprinta of chase articles arc not yet available,
but I will send them whcn they do come in.

It is good to have thc work on cyclazocine continued. It
an effective compound an&amp; I hopc that something therapeutic
can be made of it. Incidentally, we hcve bacn able t6 induct soma
patients on cyclazocine on a schedule of 1 mg, 2 mg, 3 mg and
4 mg in four days. For any side effects we have givaa either
parenteral or oral naloxone (2 mg IV or 50 mg oral) and the patients
can be discharged m uch sooner from the heapical than with methadone.
is

Sinceraly yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Eebroary 27, 1970
Mr. autumn Weioaman
Hoffman La Rocha, Inc.

Eutloy,

New

Jersey

Dost Mr. wolounuo,
Enclosed is the draft of tho proposed firot~phaoo
study of the EEC profilo analyoia of singlo done chlordinzopoxido
in adult volunteer male subjects, dotod 2-20h70. This study is
based on our dioouollons earlier this month, in which you and
Dr. Duff proposed a more dotailoé scooy of ohlordiaxopoxido
and phonobarbitol,1f a clear EEG profilo could be datinod to
a single oral done of chlordlozayoxldo.

It seems fruitlooo to uodartoko trials at 10 mg, since
good evidence that this amount may be suhathroohold, and
we have proposed trials with 25 ﬁg and multiples thoraof.
theta is

study will be undertaken in m1d~ﬂorch, and I would
appreciate your making a snoll supply of chlordiazopoxldo, a:
25 mg and its placebo available (23 oopsulea each).
The

Many

thanks.
Sineoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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m’wwr‘wmmwmz—a

u.

n lama—u ‘rrqr-“V—V—uw—I‘r'm—‘z'n-W'V-v-‘m.VT&lt;\

am...»

February 16. 1970
Dr. John A. Scigliano, Ph.D.

Consultant, Pharmaceutical Sciences
Center for Studies of Hnrcotic and ﬁrug
National Institute of Mental Health

Abuse

5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

”—7..."

Dear Dr. Scigliano:

studies of marijuana are continuing and 1 am writing
to request an additional supply. Our initial supply was from the
Our

sample NIMH-l.

Is

it

possible to request

an

additional

500 Grams?

Sincerely yours,

Professor of Psychiatry
Mszp

�</text>
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a

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A

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,

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m;

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February 16, 1970
Dr. Allen P. Burger
Chas. Pfizer &amp; Co.

Groton , Connecticut

w

,‘1

1

man

Dear Allen,

wart-rm

n'

-

Separately I am sending you the part of the sample of
thiothlxene which we are using in our EEG study. ﬁy staff
reports what appears to be a diminution in clinical affects.
If it is possible to biochemically check it against the
standard, I would be grateful to know that it is as active
as expected.
Hy

best regards.
Sincerely yours,
Fink. ﬁ.3.
Professor of Psychiatry

Max

HF : kp

,7—

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0'1""

wry-(m)!

m

February 16, 1970
Food and Brug

Administration

Washington, D.C. 20204

n
.Wﬁ...

um",

"gm-ow

Attention:

Merle

M.

Gibson, M.D.

Dear Dr. Gibson:

5mm

wimp-v.

Enclosed is a protocol and supporting data for a study
of ”i-alphavacetylmothadol as a Maintenance Treatment of
Opiate Dependence." This study will be done in the Uepartmont
of Psychiatry at the Metropolitan ﬁOSpital Medical Center. he
program is part of our ongoing treatment and evaluation studies
under the auspices of the New York State Narcotic Addiction
Control Commission.
have been advised by the manufacturer, Merck Sharp and
Dohme, that supplies of i-alpha—acotylmethadol (MK-790) will be
We

.availablo as soon as we obtain an IﬁD, and the enclosed material
has been prepared by them for submission.
Thank you

for your attention.
Sincerely yours,
ﬂax Fink, M.D.

Frofessor of Psychiatry

MF:kp
6116.

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                    <text>.‘

Y'ﬁes-«v'w

Irraw-

February 12, 1970
Dr. Edward Woodward,
A. H. Robins Company
1407 Cummings Drive
Ridhmond,

Virginia

Jr.

23220

Dear Dr. Woodward:

fcnfluramine-behavior study (#0761) was undertaken
following our observation that the EEC profile was more like
amobarbital than dextro-amphetanine. Since we had no prior
experience with studies of weight reduction and anorexia, we
proposed a study to observe the behavioral effects of fenfluramino
and placebo. Since this was not feasible without a protocol, one
The

was

filed.

double-blind, with neither the subjects nor
the observer aware of the medication given.
Tﬁe study was

In tho

during the

subjects, sedation and somnolence occurred
first few
2—4
days of drug trial, and did not with placebo,
initial
which

by the

1.8.,

reports of the subject

we

were able

medication they received. We confirmed this
breaking the first 7 codes.

after

to discern
7 subjects

by

An

analyses of the behavioral data indicated that sedation

At

this point,

was indeed the most prominent symptom.
we

cases. found only one
Since

we

were

continued the study and with succeeding

reporting stimulation.

ill-equipped to

questions of weight reduction,
difficult group of subjects.

we

answer the many

relevant

had prohloms in managing

this

In a telephone discussion, I indicated that I was satisfied
with the behavioral data, remarked on the difficulty with the
weight reduction aspects, and recommended the study be discontinued.

�//-

Dr. Woodward

With

February 12, 1970

~2—

this badkground, the following are Specific answers

to the questions:
1.

Study was double-blind.

Crossover resulted from a desire to assess the
differences, if any, in behavior. Also, since the subjects
signed a permit that included "placebo“, at the end of the study
they inquired whether they had received "drug” or “placebo”. For
the pationts who received placebo, a trial of active drug was
2.

offered.

3.
4.
I

\soo notes this letter.
Supplioﬁg see attached.
FDA:

trust this is reogonsivo and usefbl.
it Siggoroly yours,
'5.“

Fink, H.D.
Professor of Psychiatry

Max

‘

Mszp

/‘\\

//A7[\Jx7

�</text>
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                    <text>:‘zw. -

V»

w

;

-_r ....

Mm m

1“,.

.. w. m,

.

mwﬁm- "WT“,—K..."

m

v

v

v

n

mum...“

.7...

-7..-v-.w-_m.,v_ .. .,,v..r_.,..r

/

.n

,

h,

_-..‘.~_._,.a

.

.l.m.,

.,,,

.7

..

February 10, 1970
Dr. Martin Katz

\-.

'r
-

.w.,--,u.w.w—u—c~:,

&lt;1:

National Institutes of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Dr. Katz:

Enclosed

for
to DRG.

is

MH—lSSél-OZ.

“a

xrvuu

14

"thy

«mum.

‘

'(axwm:

a copy of the sppplement grant application
The original and six c0pies have been sent

Following the guidelines, the dates of the supplement
to run concurrent with the ongoing program so that
are
the first request is for six months rather than 12 months.
made

I want to thank you for the extension of the February
deadline and I would be grateful if this supplement can be

processed for the June Council.
wiwvv

Thank you

for your help.

mu—n»

Sincerely yours,
Max

Fink,

H.D.

Executive Director

MP

:kp

1

v

on

�</text>
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.1...

February 7, 1970
Mrs. Lala 8. Le;
Chairman, Ccmmittee on Mndicine &amp; Law
Association of the Bar of the City of
42 what 6k Street
ﬂaw York City

.Mpv..§.x.as~.r:-w.wsuw-

It

of your committee to invitc us to participate
in the symposium on marijuana, and we enjoyed the sasaion very much.
I rcgrat that our participation was limited to audition. since
there many inputs raisad and can» facts presented that were in
error. The issue of marijuana is in the public eyn. and the
extan-ive penalties for possession are indead absurd and dis~
proportionate, and this was clearly atated by Dr. Mead and Er.
Rothwax. Unfortunataly, both ﬁt. Rainlip and Dr. Zinbatg mgde
misstatamtnts of fact~~ Mr. 3513119 in regard to the studies
of THC and the allegad toxicity of cannabis: aad Br. Zinbarg in
not distinctly aapnrating the toxicity of opiataa from cannabis.
wan kind

Whila the problem of marijuana in acutc, the prablems
dopandencc and their treatment are not only as acute,

of opiate
but the severity of the illness is so much greatmr, uni the
'epidemic’ so much more severe, as to be a public health problem
of major magnitude. The legal issues of entorcad engagement with
methadone~« an oxperimontal drug~¢ or the justification for
incarcaration without traatmaut may have been discussed, but
sacm to us still :9 ba open innues. Ferhapa your committee may be
interested in discussing these problems at another occaaion.
Again,

1114mm":

x

York

Beat Mrn. Laa,

”hamburg,

”WWW‘MA”,

N$W

your excallent

my

wife and I thank you for the invitation and

haspitality.

Sincerely yours,
Fink, 24.9.
Prateasor of Psychiatry

MRI

uf/

�</text>
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                    <text>February 6, 1970
Dr. Robert Kokaski
Director, Drug Abuse Laboratory
Spring Grove State Hospital

Baltimore, ﬂaryland
Dear Dr. Kokoaki,

Thank you for the report of the analysis of our
unknown
of
substance, which apparently contained
sample
heroin. This is indeed helpful, and we are grateful for your

assistance.
at the

NRC

I trust I will have

meetings.

an opportunity to see you

sincerely yours,
Fink, 3.9.
Profeanot of Psychiatry

Max

mf/

�</text>
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                    <text>February 6, 1970
Dr. Bidney

Halitz,

APA¢Diatriet Branch
250 west 57

New

M.D.

Street

York City

Dear 51d.

I thank you for your axptasaion a! confidence in
the appointment as Chairman of the Cammittaa of Biological
Tﬁnrapisa of the district branch. and would like to accept,
but an unclear as to the reponaibilitien of the asaignuent.
Is the committee appointed already. and who are the Numbers ?
0:, may I recanmend a committee from the membarchip for your
approval ?
Are there questions before the committee? Are share
ongoing projects that may be raviewad and centinuad, at is the

coumtttee beginning

anew ?

I will call you to éiscuss these questions before
replying ta your kind recommendation.
My

best regards.
Sincerely yours,

Blnfatnhr ufnroychiacry

�</text>
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                    <text>February 6. 1970

,w

Mr. Robert Marlin

mwvrP-KI-"p—‘Il—IIWVF‘

Sande: Pharmaceuticals
Hanover, New Jersey

mm—m

..

Dear Mr. Marlin,

w-v.-u..y

&lt;

”-..—W)“-

"-

usu-wm-u

rmvl'"

,

7

Thank you for the information on thioridazine in
the treatment of anxiety in out-patients. The data is helpfui.
suggesting both a very broad range of dosages that may be
effective (30»300 mg/day) and a high degree of safety. There
is no satisfactory comparison against a standard antiﬁanxiety
agent, however, and I wonder why this has not been examined.
I checked my reference texts as well, and found some references for
a few of the antipsychotic agents. but none for Meiiarii.

.-u-

m

-qrv~

As I mentioned, we are inciined to undertake
of Meiioril in out~patient anxious neurotics.

The

a

study

study of 542.548 is progressing well.
Sincereiy yours,

-

7mm-

n.»

.....u—unyq-wwa-w

Fink. M.D.
Profossor of Psychiatry

Max
urn-w")

Jaw

A,»

.‘A‘v-W‘uy,“

,;,~w~g_

«m.

A

“’lwr'wa'yn’"!

wWVVm‘A't."

.
w

mf/

�</text>
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                    <text>-,y....,,.

r,“
I.

Febmary 6, 1970
Mr. Barry Henderson
World Wide Medical News
110 East 59th Street
New York, New York

Dear Mr. Henderson:

for your inquiry about our presentation at the
This report was an up-dating of a review I completed
in 1968 and our recent studies in opiates. Copies of both

EPRA.

Thank you

are enclosed.

Sincoroly yours,

Prodbssor of Psychiatry
MF:kp

�</text>
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                    <text>~—

V

".7"...

, ....m- ,m

A

-

‘vrym-‘uw

--'"'n"mv-m|n ~,J—a.v1.:m, D’s-Inv'm—p'r.

-

r,

n..- N‘v‘muw-m

mgv..-~w-vmn—.W‘www

.n-uw—w;

~7y.a'-&gt;wav~wwu-~PI“V—Frrf—I'wvw

Fibruary 6. 1970
Dr. Robert Iokcski

Director,

Drug Abuse Laboratory
Grova
State Keepital
spring
Baltimore, Maryland
Dear Dr. Kokoaki,

for the raport of the analysis at car
substance. whiah apparently containeé
Bangle of
heroin. This is inﬁaad hnlpful, and wa are grataful for your
assistance.
Thank you

unknown

a: the

I trust I will hava

was meetings.

an apportunity to see you

sinceraly ycnrs,
Fink, H.D.
Preteens: of Psychiatry

Nan

mf/

1..

~

,

“WV

‘

v

r". “w. (”W— _,

�</text>
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                    <text>wow-w—

.~
&lt;

m

.,

r
w,

u

wwmw.u.r.wn

mwr

”Ir.-

February 5, l978
Dr. ﬂax Singer
Quaker Bridge Road
Croton on the Hudson. ﬁew York l0520
Bear 3r. Singer:

visit

a few weeks ago was a disturbing experience.
The State authoritias wara once again seeking a review of drug abuse,
and the chaice of a team without prior exparience in similar medical
Your

problems. highlighted the bankruptcy of tha existing

ﬁat,

if we

state efforts.

are prﬁsumad to be experienced, what pro rams
burst of activity, I éictated the ant osed

do we suggest? In a

untes.

In reviewing these notes. I am aware of how little we know
of érug abuse - how it starts; the physiological changas; the
pharmacology of the drugs and their antagonists. ggg;_
It is

clear, however, that there art axtensive differences betwean
apiates and cannabis « the opiate dangers are clearly definad;
the cannabis dangers overdrawn and unsuhstantiated. while
intensive research an ogiates is mandatory, a maratorium
a moratorium on imprisonment.
an cannabis can be safely antertained
new laws, legalization combined with an extensive study effert
to answer the cogent questions 9f the suprlies 0f cannabis and
m

their dangers.

cf

against opiates is not too
our nation seems embarked on a 5 billion dollar annual
expenditure against a Chinase threat * is it too much to ask
absurd
$530

Perhaps the analogy

5 “war”

~

millien for

a “Chinese“ epidemic?

May I submit a special plea. for inclusion in your report
regarding opiates? ialoxone in a silastic vehicla is a simple,
direct and feasible aid in treating this disease. The funds needed

�.

Fwy

rm-

-

~r-v-vn

wwwm'mmmm

man‘s-zap

.m-

.-,. .vﬂ—pw,

-. .V. W——M...

.

,

.uW‘wwn.—w

M, s.

"-Yw-ri wawmwx -—u—-~-mv7ww———cw——-.--:

.7“? Team-WV." -V-

-2-

Br. Singer

.......- u.

».

__,_,

“.7 ‘m,——.1_’—.-w.

wvr,....._..

.

WV

vamp—"q...”

February 5, l970

for development may be small in amount ~ we have asked $70,000 the
first year and yet, the promise is so great, that this nominal
expenditure should he "slipped in” among any recommendations. If
successful, the rewards will be most gratifying. If unsuccessful,
—

the loss
I

trivial.

while

would be

of your

understand your report may have a restricted distribution,
qrateful for the opportunity to review a copy with a member
I

staff.

Sincerely yours,
ﬁax Fink, %.U.

vrofessor of ?sychietry

ﬁF:kp

cc:

Mr. Gus Tyler
27 Stoner Ave.

Great ﬂeck,

New

York

.

.

�</text>
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                    <text>‘

"WW-"WW

rummvw-

WW.mmxiww‘

“a WWW-w“,«mp-unm
rv-m

,

V

,

,

.

“we-WW we.
,

.

,

meumw

,, W "ma-mm
_,

um .‘lm-‘WHW."M_.‘..,

w , w.

W._.w..~~,uu—w-xmWWII—V

February 4, 1970
Dr. Simon H. Nag1er

Department of Psychiatry
Metropo1itan Hospitai Center
1901

New

First

York,

Avenue
York 10029

New

Dear Sy,
he have no "innovative” ideas on how to supervise residents
mode]
in psychiatry. We have proposed that the continuous care on

emphasis
of the Division of Bio1ogica1 Psychiatry, with our
tempora1,
artificia1
a tota1 treatment approach, without
a usefu1 experience
phi1osophica1 or moda1ity restraints, may beone-ha1f
the patients
than
more
we
that
aware
are
for students.
- and higher
reuadmissions
services
are
admitted to our inpatient

emphasize, therefore, some experimenta1
of interest.
approaches to therapy, and this, in itse1f, may be uni1atera1
ECT
as
innovative,
are
Sure1y, some of our techniques
and mu1tip1e monitored ECT for depression; na1oxone, cyc1azocine
f1uphenazine enanthate
as “engagers” for opiate dependence; injectab1e
and doxepin
and decanoate, and e1ixer butaperazine for schizophrenia;
and high dose ch1ordiazepoxide for anxiety. Hot to forget ourand
specia1 interests in 1actate precipitab1e anxiety, cannabis,

for drug abuse subjects.

We

EEG.

V

,,

“WWW“,

,;
'M'm

w.»

.r-

-

a staff
Sureiy, among this wea1th of nove1 experience, withFe1dstein
(Professors);
Shapiro
Kee1er,
consisting of Drs. Fink,
Simeon, Vo1avka
(Associate Professor); Dornbush, Resnick, Rubin, and
Zaks (Instructors) Major
(Assistant Professors) and Abrams, C1are,
and
we shou1d be abie to engage a group of enthusiastic,bright
dedicated residents in a reciproca11y rewarding experience!

,.

Sincere1y yours,

“n“,

n
n

Fink, H.h.
Professor of Psychiatry

Max

‘1',“

’

.

.11"

MF:kp

wwl‘wm‘ww-we-gm,

wnwm

:i-

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“2,1218

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                    <text>-.-uﬂ

TO:

Alfred

FROM:

Max

M.

Freedman, M.0.

February 4, l970

DATE:

Fink, M.8.

SUBJECT:

Attendance at Executive Faculty Meeting

The

principal issue at the Executive Faculty

change in curriculum

third
Dr.

was the

increasing weeks for medicine in the

—

and fourth year and decreasing psychiatry and surgery.

Jaffe indicated that psychiatry

in a gentlemanly fashion.

great concern that this

The

had accepted the decrease

surgical representatives voiced

recommendation would be

disastrous

to the surgery training program.

It

that

was my impression

Dr.

Jaffe's report

was poorly

described with inadequate support of the numbers in the proposal.
He

was unprepared and

had many

errors in

On

a vote

On

a vote

insisted that the report submitted (appended)

it.

to table,

W

I

abstained.

to accept the report,

I voted

The/yote was not accepted l3 to 12.

MF:kp

against acceptance.

�</text>
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                    <text>Fébtuary 3, 1970
Dr. 3. K. Vanov, M.D.

The Upjohn Co.

Kalamnzeo, Michigan
Dear Dr. Vanov,
Thank you

for your inquiry

in the «valuation programs of

anti-anxiety

compounds.

new

and

invitation to participate

paychotrapic drugs. patticylarly

Dr. Signet may have describad, our principal interest
is in the identificatian and classification of novel psychoaetivn
agents by neuraphyaiologic, particnlarly EEG, measures. Our clinical
atudies are derivativn, and we have undertaken clinical studies
As

to support our EEG determinations. Wt have iénntified the paychoactive
properties of eyelasocine, doxepin and fanfluranine by EEG prefila
analyses, and now are engaged in the analyses 0f four ‘nuaberad’
campounds. For ant of thgsa, 641299, we hava begun the clinieal

trials.

undartake chase mtudias we require saw» evidenca of
the aafaty of the compound in man, preferably normal adult volunteara,
and a aynopsia of the desage/aninnl data. May I nuggcst that if such
an analysis in of intarest, that you arrangt to visit our laboratories
at your canvcniance, and revicw the type of progrnml which are now in
progress 7 It may be particularly helpful if you sent at a capy of the
information which we raqueat. no that we could discuss a specific
protocol during your v151t—~ but, this 13 nut necessary, and may be
defeated.
To

Thank you again

for your intnralt.
Sincerely yours,

mm.

133'!"

'a,i«

Max
-t
4,.

”my...

Wr-Q-w

.
x

«r

w—w

r’ﬁ“

Fink,

M.D.

Prefesaot of Psychiatry

”MW

nf/

�</text>
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                    <text>February 3, 1970
Dr. A. M. Schneider
Departuznt of Psychology

University Callas:
Raw York University
Bronx, Kev York

Dear Dr. schnaider,

discussions in Aspen, and have
tried to ahara my notes with my asacciates. gay I aﬁk that you
send an capiao 0f ynur more recent reports an memory changes

I vary

and

cansolidatiun

much enjoyed your
?

Enciosed is the program of tha APPA which is maeting
1n Raw York February 13 and lé. $ome of the reporters era well
known and yen may enjey the presentations. I am encouragad ta invite
you to the cocktail party, and look ferward to welcoming ymu.

Sincerely yours,
Max

Fink, M.D.

Profaaaor of Psychiatry

mf/

�</text>
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                    <text>February 3. 1970
Dr. Gerry Klarnan
50 Alston Avanue
New Haven, Ibnnocticnt
Dan: Gerry,
Tue waeks agc I had the uncond matting with editars of
Planum Publishing~~ first with My. Uball and than ﬁr. Weingnrten *w
who discusuad the foasibility and negd for an ad&amp;itiona1 journal
davoted to drugs and behavior or drugs and btain function.
I hulieva

that there is naed far such a journal, particularly if it is dedicatad
to studies in man. Mr. Whingnrten revicwad a list of our co~workera
and friands with wham he had spoken, and I ahareé with him some of
my views cf the mark they had dune.

It ans apparant that he was favcrubly inclinad to the
support of thin vanture which yen had axvralnad. and I encournged
him to continue to elicit your support. Thu mattings next wank at
the ﬂaw York Eilton may provide the oppnrtunity for a revicw of this
suggestion, and I hope that yau will provide the guidance which

ha

may

require.
My

be arrangeé.

been ragarda. and I do hope that something can

Sincerely your».
33: Fink, M.ﬂ.

�</text>
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                    <text>February 3, 1970
Hr. Scyneu Weingartan

Dear Mr. Weingnrten,
Bur laboratory

is equigpcd with

an MIST and we have a

has bean my adminintrative assistant for
well trained operator
nlaost 5 years. This unit is part of tha extensive aquipmnnt,
both alectronic and computer, of the laboratory.
who

I

do

not

know

of any other laboratory similarly

equipped in psychopharnncology, although I dié reconmand to
my good friend. Charlas Shagaaa that he opould obtain such a

unit.

Sinceraly yaurs,

Fink, H.D.
Professor of Psychiatry

Max

nf/

�</text>
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                    <text>"-

‘“

"9‘

"

x

-"-v-

'

"i” '6'“)

»\'-.r.«-

«ﬂu-«m»

saw—aw

mummww—w‘wo "ﬂ“.

-7“—

my—

Fabrunry

3.

1970

Dr. Gerry Klernnn
50 Alston Avenue
New Raven, connecticut
Dear Gerry,
Tua wegks ago I had the aecoad meeting with editors of
Plenum ?ub113h1ng~~ first with Mr. Uball and than ﬁr. Weingarten *«
who discussed the feasibility and need for an ndéitional journal
I believe
devoted to drugs and behavior or drugs and brain function.
dedicated
in
if
such
it
15
a
need
particularly
for
journal,
that there

to studies in man. Mr. waingnrten reviewed a list of our cauworkara
friends with whom he had apnken, and I sharad with him some of
of the work they had éone.
views
my
and

was favorably inclined to the
It was apparent that hehad
which
expressed, and I encourageﬂ
venture
you
of
thia
support
him to continua to alicit your support. Tha meetings next week at
the new York Hilton may provide the opportunity for a review of this
suggestion, and I hopa that yen will provide the guidance which

he

may

Inquire.
My

be drrnngad.

has: regards.

and I do hogs

that something can
Sincerely yours,
Max

.,,,

_..r,.,.

m

nvr

“7",...“

army.--

~
.

'mbuW-DVWW-

Pink, 3.9.

�</text>
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                    <text>February 2, 1970
Mr. Robert Uball

Plenum Publishing Co.
York City

New

Dear Mr. Ubell,

are trying to obtain the funds to launch the
at a date earlier than we had planned
(with NINE support). We should know by the and of February and
we succeed the meeting will be held June or July.
We

conference

on marijuana

If not,

we

hepe to hold

as soon as the funds allow.
Thank you

it

in the late

fall

if

on

for your interest.
Sincerely yours,
Max

sink,

M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>February

l.

l970

Professor Paul Kielholz
Editor. Phareekopsychiatrie
Basel, Switzerland
Dear Dr. Kielholz.
I have

just received your letter regarding

a

report

on “Methadone Maintenance Treatment" for the special issue on
Drug Dependence of Phereekopsychiatrie. This was addredsed to
Bellevue Hospital and was not received until yesterday.

pleased to contribute to such a volume,
be broadened to the general topic
of pharmacologicll treatment of opiate dependence. To review the
use of methadone alone is too restricted. since we have more ex~
perience with cyclazocine and naloxone. A description of these
three approaches. as we now use them. and as we propose to use
them in our future prograns. may be more useful than one devoted
to methadone alone.
provided

I would be

that the subject could

If,

however. someone else is already covering the

antagonists. then perhaps

he would be
methadone treatment as well.

willing to report

on the

It is not possible to meet the deadline of January 31,
l970; since that is the day I received the letter of invitation.
The report could be written during the first two weeks of March and
sent about March 2i, at the earliest.
which I

I thank you

also for the answer to the

will respond to in the next

few days.

CINP

program.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>——

l

-.~mmnu——~——vm mam_w.—.v

ﬁarch 30, 1970
Dr. sidney Merlis
Central lslip State Hospital
Central Islip. ﬁe» York
Dear Sid,

for

I would like to second the nomination of
membership in the ACNP.

ﬁt. Ali {cskiner

0r. Itil and I were responsible for bringing ﬁr. Keskiner
United States upon the completion of his treining program
the
to
Montreal.
in
Since 1964 he has been an active member of the stuff of the
Missouri Institute of Psychiatry. For the first few your: he was
in charge of the patients of the chronic schizoyhrenia project,

studying the effects of butnperetine, L59, Bitten end atropine
in altering the behuvior of the therncy resistant petients.

He has done same of the most extensive evaluations of fluphenazine
decanocte. Based on this experience, he has undertaken and is new the
principnl investigator of I study maintaining chronic psychotic patients
in a farming community. He is able te do so by delivering medication

in biweekly dates.

ACE?

I am pleased to recommend Dr. Keskiner for membership in the
as I believe he will make significant contributions to our

study groups.

Sincerely yours.
Ht: Pink, %.0.
Professor of ?sychiatry
$3? :11}:

cc: Dr.

Itil

�</text>
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