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                    <text>June 24. 1969
Dr. Fred Clark

A. H. Robins Company
1407 Cummings Drive
Richmond 20. Virginia

Dear Dr. Clark:

In our studies of AHR-l900

we need additional supplies.
please ship us 500 capsules, 200 mg the an equal
number of placebos. Sample labels are attached.

Would you

Many

thanks.
Sincerely yours ,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>June 24. l969
Dr. G. Verdeaux

Leboretoire a la Faculte
48, Rue de Grenelle (VIIe)

Paris. France
Dear George.

If three references are all that are required, please

ones marked on the attached xerox copy.
I hope that the summary
the completed manuscript.
I

was

trust I will see you in

use the

useful and I look forward to seeing

New

York

after the

San Diego meetings.

at my laboratories either Nednesday,
September 24. or Thursday. September 25. and I will write to you soon.
I an

trying to arrange
My

a session

best regards.
Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 24 , 1969
Miss Jo Hawkins
Associate Director

Rush Research Foundation

9201 Sunset Bled.
Los Angeles,

California

90069

Dear Miss Hawkins:
I have checked my files and find neither a letter to
Dr. Grinker nor a letter stating that I have made such a

request.

Enclosed
Dr. Brinker.

is

a

letter

which I have

Just sent to

Sincerely yours .

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>June 25, 1969
Dear Ernst,

There are only a few references 00 the

EEG

effects

of cannabis, and none recent. The most interesting is an unpublished
report by K. Miran, describing some increased slow wave activity
in chronic hashiah users. This will appear in the symposium on
marijuana edited by Wittenborn.

other reports are old and include:

The
Amen,

F.: J.

Ment.

Sol.,

1958, 104:972~999.

Williams, Himmelobach, Wikler, Ruble

&amp;

1946, 61:1059~1083.

Lliyd: ?ubl. Hlth. Repto.,

Wolstenholme, G.E. and Knight,J (Eds.): Hashiah: Its Chemistry and
Pharmacology. Little, Brown &amp; 00., Boston, 1965, 96 pp
has some

also wish to examine the LaGuardia report which
data (although poor) and the preliminary report by

You may

EEG

Hiklar and Lloyd in Fed. Proc., 1945, #:1él.

My own into is in progress; and I have recently analysed
tapes front Reece Jones at Langley Porter, but this data, too,
is incomplete.

some

You

will

be pleased to know

that I

a symposium on cannabis/EEG/psychological

am planning to add
to the next CINP meeting,
,

if my co~chairmon let me got away with it. If not, perhaps you will
present your data somewhere public so that we can discuss it.
It is

obvious

we

need more modern data, so good luck

I trust I will see

you in

California.

Have a good summer.

Sincerely yours,
Max

mf/

3

Fink, M.D.

�</text>
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                    <text>NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST lOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

RECEIVED

JUN

June 24, l969

301959

R. .W. MAYQ

Dr. Roy Grinker, Editor

Archives of General Psychiatry

American Medical Association
535 North Dearborn

Chicago,

Illinois 606l0

Dear Dr. Grinker:

writing to request permission to republish a figure
my reports which appeared in the Aachiveé 06 Genenaﬂ
Paychiatny. I would like to include this figure in a summary of
our experiences with depot fluphenazine which will appear in a
volume entitled "Changing Patterns in Psychiatric Care", edited
by T. Rothman of Los Angeles.
I am

from one of

May we

have permission to republish the

figure

from the

article "Long-Acting Phenothiazine (Fluphenazine Decanoate)
Treatment of Psychosis" which appeared in Vol. l8, page 479?
Thank you

for your cooperation.
Sincerely yours,
Max

ﬂ“, EMA,

Fink,

M.D.

Professor of Psychiatry

MF:kp

cc:

7x3

Miss Hawkins

PERMSSSSCN
UPON

swam

5,
cam-nan, CONTINGENT
APPROVAL BY AUTHDR.

JOHN H. TALBOTT, MD, EDITOR. JAMA

‘33

DR.TALBOTT
&lt;'

JUL 2

$5

‘9

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§§¥ {Kg

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�</text>
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                    <text>-;-w~u

June 24. 1969
'rw-w'nww-ur-pw.

Dr. My Brisker. Editor
Archives of Genera! Pa chiatry
Marian Medical Assoc etioe
535 North Durham

'

Guiana. Xiiimia

60610

Dear Dr. Brinker:

i as writing to request per-iaaion to republish a figure

aredinthemumaﬁw
thia figure in a emery of
mid like to mlude
ma «pot fiuphenuine which will appear in a

fmmofwreportawhicb
1
Pa

.
our expe emu
roiuu entitled
by T. Reuben

of

“Changing
Lou

Pattern: in Psychiatric Care“. edited

Monies.

have permission in republish the figure from the
Phenothiazine (Muphemine Decanoate)
articie
Treatment of Psychosis“ which appeared in Vol. 18. page 479?
Meg we

Long—Acting

Thank you

for your cooperation.
Sincerely yours.
ﬂax Fink.

"m'kf‘qaf

.

‘0:

ng-p-r-z-«yaw

cc: Ilia:

u.-,

Wy

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".0.

Professor of Psychiatry

:

Mina

�</text>
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1969

Mss Jo Hawkins
Associats Mmtor

Rush Rosssrch Foundation
9201 Sunset ma.
Los Angaiss, California 90069
Dear

um

Hawkins:

I have checked av ﬁles and ﬁnd author a letter to
Brinks!- nor a latter stating that I have made such a
roquss .
Dr.

Dr.

Enclosad 1s a

Maker.

letur

which I have Just sent to
Sinosro‘ly yours .

Has

Huh. ".0.

Professor of Psychiatry

�</text>
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                    <text>December 3, 1968

Dr. Ted Roth-In
Rush Research Foundation
has Angelou, California
Dear Ted,

Fluphenazine

is the draft copy of the report, "Depot
Facilitation of Treatment of Psychosis", summarizing

Enclosed

the experiences with both long-acting depot forms, in Missouri and

in

New

York.

are pleased to have had the opportunity to participate
in your volume, and wish you all success in this venture.
We

My

best regards.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

MF/

�</text>
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                    <text>June 24. 1969
Miss

Stockert. Chief Pharmacist

Monmouth Hedicel
Long Branch. New

Deer Hiss

Center
Jersey

Stockert:

Recently. I visited the Monmouth Medical Center on an
seminar. New aspects of the program were impressive.
but the most imdietely velueble was the up-toedete fomlary.
Our Formlery Cmittee has struggled with the need and
desirability for a detailed compendium of available drugs.
IBM

if a

recent

mny

ﬂaws.

we would be most

copy of the

grateful.

fomlery print-out is available.

Sincerely yours .
Fink. OLD.
Professor of Psychiatry

Hex

Hrskp

�</text>
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                  <elementText elementTextId="102915">
                    <text>w

y1
_.-:

”.iﬂhﬂ'ylgm;

«.w,

waxy?

SCW-MIW

“Vivi“

"‘1

Juno

2’5,

1969

Soorototy

o! Roooorch rocilitioo
um annoy
Broio Bcioocoo

in

Notion).

lotionol

Mouth
Aoodooy

ﬂoohiostoo. n.c.

Council

of Sciooco

boot Giro:

hook you {or o copy at tho mo Botvoy of looootoh tocilitioo
ond Honpowot in Main Scioncoo. It io indood o moivo took. gonotolly
won. dooo, out o voluoo thot will hovo iuoodioto utility.
-

a

writing
io ooticipotod thoto oto oooo ottoto. ond I
tho out
to count oolo choogoo which ohooid ho incorpototod innow
York
tho
oditioo. I wito “cording tho oootioo doyotod to
hoodod
by
Llodicol Couogo. pogoo 213-215. rho fiool mogropho
"tho Btoio noooorch ..." contoio oooy ctroto.
Ao

Doportoont of Poychiotry. hoodod by A. ll. hood-on (Choinon)
(Editorial Boord. Anoticon Joutool Orthopoychiotty) hoo on oxtonoivo
lRho

in two
pronto: in tho tolotioo of broio function to hohoviot. dividod
N.
(
Pink.
principoi divioiono - tho Divioion of Biologicol Psychiatry
R.
B.
Ditoctot).
John.
Diroctot) ood tho ntoio Roooorch Lobotototioo (
tho Divioion of Biologicol Poychiotty io mootood with tho roiotion
of BIG chagoo ond hohoviot in non. opocificouy tho iotioonoocf

ioduood oonvoloiooo. poychotropic and holiucioogonic drugo. ond opiotoo
lobotototioo. coo with oo-iino
on no. no ﬁocilitioo includo thtoo
oooiyoio ooio; on Ila-1800 oyotoo; toot topo oyotono; and 25 bodo for
poychiottic tooootch. Tho ooiootioto includo Dr. D. u. Shopiro, cooputot

m

molyoio of biooloctric oignolo; s. Foidotoin, poyoholinguiotico;
3. Dornhooh. ooooty oochoniooo;
J. Volovko. nonotivo quootitotivo no;
H. Koolot. odvotoo offocto of
J. noobicok, BEG out! holluciuogooo;
hoilucinogono ood comb“; out! )4. Fihh (Ditootor) . quontitotivo
drug offocto. induood convuioiono. and hohoviot in poychiotric
m.
ouhjocto ond natal volootooto.

Division will mo to o tic-unity Montol Boolth Contot in
1970, vhoro opportunitioo to: ditoct clinicol - oourophyoioloxiool
otudioo win ho oxpoodod to o 50 bod rooootch unit.
rho dooctiptiono of tho Btoiu Roooorch Lobotototy oro oooontiouy corroct.
lrho

hook you for your cooporotion.
Siocotoly youro .

7123‘

“I",

“523:3!"

”C.

F
771.

I'm-mom»

Ho: Fink, 24.1).

Professor of Psychiatry

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                    <text>&lt;

n

w

w

Y,._..—»-v...r-—"4~wn‘

.

7

.....

2

“m w—

W...

,m.

«wrwvvmew—F

................................Y1kildliq33&amp;u3 3330nqqﬁ

eﬁz 30

ahrsbntjs as?

ion at jroqox std? :notouisqgg

03 qu

goljeovejnk aid: amines:

Try—r‘. -~.——»——.-—w—w——,&gt;.——_.

has 332

.lsnzuot

30

valnujroqqc ed:

103 uov

333

inng

June 23, 1969

.zboje anilq

Dr. Peter Kallaway

Baylor College of Medicine
Houston, Texas
Dear

Peter,.31unv vtexsonkl

I have read and re~rssd the article. "EEG and Hypnotic
Susceptibility"; and when my recommendations appeared imprecise, I
shared the report with my associates. Our conclusions are mixed, although
the recommendation is specific.
.W.V

ﬂirt? ts”

v133errmmect

is a

good one, and the problem important.

desire to relate a behavioral variable (hypnotic suggestihility)
with a quantified set of EEG variables is coeesndabls. hath measures.
that of behavior and EEQ are well selected, and seeaingly are the
most efficient available.
\lv
The

Negative: The attempt to relate an attitudinal variable
with EEG measures collected at disparate points in time has been
unenccessful in most studies; and when a relationship is reported,
it is usually not sustained in later studies. The best relationships
are those measured in close temporal relations-- the closer the better.
so

of

that errors

64 spa

due

The sampling rate is low: the filtering inadequate,
to aliasing are highly probable. (A sampling rate

leads to folding of

60 cps

in 3-5cps).

The Grass 3 dB

contribute to this difficulty and especially if the authors are
not aware that many Grass instruments bypass the filters for the
tape outputs. This should be enquired into in their system.

filters

Sample sizes are very small, and the use of means
spurious. What variability measures were used? Were split samples
(#5 vs £5. or 30vs30v930) assessed to insure that the variability of
these very small samples was not excessive ?

may be

Five significant measures of 96 (at a minimum) or
of 600 (at a maximum) are not impressive. Especially if they are
derived statistically and not from any theoretic point of view.
The absence

of a priori hypotheses degrades

studies, and I regret the authors did not choose to make their ideas
clear and test them. The statistical approach to science is very unsat~
isfactory.

«Wm-r

.—

�QMG
‘\~.

WMWt1¢samttbintyo3uoco39.303.3333333933313393...

6033133133: 11113

Journsl.

EEG

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report

than

239: .33 sent

13,

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                    <text>.7,,.,~-V....V.,.~.—.mmm‘

qmﬂmﬂvwaw-

~

.

..

u",
M
fF//&lt;(
I

fa

,1?”

/;JVL

Juno 22, 1969
Dr. Jo Dragoons

Jansaen Phnrnaooutica
Baotou, Balaton
Door Dr. Brugmnna,

R—6218.

Thank you for the dolcriptivo litoraturo on R-6238 and
which both my nusooiato, Dr. Jovuu Stucco and I havo road

much interest. The special nature of tho population for whom
pinoxido to rcoolaendod is clearly scatod, although the juatifioation
cacao-I on. Ruvnrtholoaa, we are interestad to those compounds, ond
I an writing to suggest that you visit those laboratories on your trip
to tho U.8., which you indicated would be focthconina at the and of

with

Mypmvmwwc:

m
‘

this

I can be roachad at my office most afternoon: (212-369 7900)
and would be plcaood to arrnoge to have you visit both our laboratories
and our clinical £3c111t1cn.
Again,

V&lt;'Q\'.

-

“7mm“,

month.

my

sections in Lingo,

thank: for your help in tho trunclattonu of tho
for the description; of pioozide and fluopirilonc.

and

Sinooroly yours,
Max

mf/

Fink, M.D.

Professor of Psychiatry

�</text>
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Dear Dr. Boyer,
no are in the midst of an evaluation of the initial
pyrovalerone data and it should be possible to review this on
Friday. May I ask that you join me at my office at 5 East 102
at 1:30 p.m. ?

I look forward to your

Street

visit.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>June 20, 1969
Dept.

A

Upjohn Co.

Inglewood, California

‘9

Gentlemen:

I would appreciate additional information on your new
program of Laboratory Procedures, as described in tho recent issue
of the

JANA.

Thank you.

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Mr" .

June 16, 1969
Committee on Brain Sciences

National Research Council
Washington, D.C.

Gontlenen:

Facilities

would appreciate a copy of the 1380 Survey of Research
and Manpower in Brain Sciences, as doacribad in a recent issue

we

0; the Mental Health Digest.
Thank you.

Sinceroly yours,
”may—'wW'i

Max
-73;

ka, rm).

Professor of Psychiatry

KC

m

(

‘.

X
a

\

r

a

in}?

G

a

l

.h
-.

Ti

,\\

�</text>
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                    <text>-r-'(~

...

m,¢:m"pr

w,

.1'

(1,1;

mﬂku;

F—uwv

June 16, 1969
Columbia University Praas
York City

Raw

Gantlanon:
Ha wnuld like to rocive a copy of the W80 Technical Report
#381, Neurophysiological and Behavioral Research in Psychiatxy. If

that: in a chargn,

we

wil; remit promptly.

Thank you.

Sincerely yours,

Max

Fink, 3.0.

Professor of Psychiatry

at]

�</text>
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                    <text>June 16, 1969

Office of Public Information’
National Library of Medicine
B¢thaada, Md/

Gentlemen:
my.“-

w.“

We

would appraciate engine of the following two

bibliographies:

.A.,;,.mw,y—nm.

3-69
4*69

PsychotrOpic drug addition or withdrawal symptoms

in

man

Cannabia toxicology

Thank you.

Sincerely ypurs,

Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>June 12, 1969
Mr. Robert L. Marlin

Sandor Pharmaceuticals
Hanover, New Jersey 07936

Dear Mr. Harlin:

Enclosed are two draft copies of our protocol for the
study of S 4-25h8, and a form FD 1572.

In the event this protocol

appreciate receiving 50,

2 mg

like
tablets are not available,

and a

is satisfactory, I

tablets (capsules) of

may

initial

S

-

"gr

Sincerely yours,

v'

.
—-l

-u'

.w

-;.V-.—

,r
v

_-

Pink, 11.1).
Professor of Psychiatry

Max

H.

1.2;“

,~
v.

,r
.-..

'

v

‘vxna...

'v-z'xaxxwwr

112m“

~15"-

wvw'."‘,"X7.nij'.:

MFtkp

4-2548

supply. If 2 mg
I request 100, 1 as active

number of placebo as an

and 100 placebo.

would

�</text>
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                    <text>June l2, i969
Dr. Thomas Williams

National institutes of Mental Health
5454 Wisconsin

Chevy Chase, Maryland

Dear Tom,
look forward to seeing you at Gracie Square Hospital
(420 East 76th Street) on Thursday, June l9, at IO:OO am.
i

Please

come

to the laboratory

Enclosed is a

the

first floor.

draft cepy of the report

the data until April
My

on

i.

which summarizes

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

fokp

�</text>
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                    <text>~._-.—,-.m—w- ,,.- 3:“-:v

.1"

L &gt;7.

xx c“.

.

vv¢-v.vwv-1~vuvw' -vrq—w;a..—r--rmr-.

~

gamma-um

-

~

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~,

w-w—r

m

7-7,

-

vw

we .Vmwwrn

&lt;

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——

.m

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June 11. 1969

nwvlr‘r‘

.A-

m

..

nut-mm

Dr. Joseph Hortis
Haimonides Comun‘lty Henta1 Hea1th Center
4802 Tenth Avenue

Brooklyn.

New

York 11219

.

Dear
“rue—V...“

aw

m?

W

yw;vm-wwm.m—rnr'us—m

7mm“.

.Aer

u...“

v_,;.v.e

b'wv‘.‘

Joe.

report “The Cerebrai Reactivity Modei in Schizophrenia
Re-Appraisai' was not presented at the Society of Bio1ogica1 Psychiatry because we had not comp1eted the ana1yses in time.
It is un1ike1y that I wi11 have the paper ready within the next
few months and suggest that you de1ist this
report.
The

A

Sincere1y yours,

Fink. M.D.
Professor of Psychiatry

Max

rt _,,,_,,

wet-v

v

�</text>
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                    <text>W

Dr. Allen P.
Associate Director

(has. Pfizer

8

00., Inc.

Groton, Camecticut 0630.0
Dear Allen,
Enclosed is a proposed analysis of CF 115368. Instead
of the usual two-step, I am proposing a three-step study in
which the first few subjects will be studied in an Open
eituatim in order to determine dose - time relationships.
A defined Open study will give us the approﬂnate classificatim
and

this will follow Dr.

Itil's

reconnendatims.

If we

are

successful with both these steps , we will have the necessary
infometim to do a definitive classificatim study.
Dr.

Itil was most helpful.

If this program meets with your approval I would appreciate
a supply of 50 capsules (tablets) of 50 mg C? 114,368 and an equal

umber of placebo.

The study can be begun as soon as supplies

are

made

Sincerely yours ,

1m PM,

2". DO

Professor of Psychiatry

MFﬁcp

,

n;iw,v.,mw.y..,

«w

~/('

.w

.

“r.

.
.

June 3, 1969

available.

�</text>
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                    <text>W

"W

v

weanww—J-w-

7.w_mnrwnw——vrvw—wmm

,
gyuguqmr

nun-

H“

_

...“

,,

,_

”no“.

I,

.v

J._

_

”...", mum,”

_‘..r v;

,1, w.“ ..i. ,V‘“.

.

W“

WWW“ ,mw-

.

...

W7-

.-

t

,, vul- Awm-‘m-q-

,m-rm‘m

-

'v

.

-: —,r..«-u-.—--

w;

~:

,-:

June 3, 1969
Dr. B. G. Caille

Phitre de

Redmes

du Service de Santa dea Armees
Chef du Centre d‘Etudes at de Recherches
du Service de Psychologie Appliquee
de

Arsenal

la Marine
- Tmlon,

France

Dear Dr. Caille:
had hoped to be able to attend your meeting, but find
that our funds for international travel are frozen. I am
saddened by the thought that we are unable to participate in
We

ymrfinemetingandoanmlyasktlmtifﬁmds caz'xbemade

available from your- crgmization we would be pleased to send
Dr. Shapiro or myself to present the work of this laboratory.

'wulﬁ'm

.wmm

n":

‘r‘c'x-n-

:rrr

Um

.‘Q’

It was kind of you to invite us and I trust that your
organizing committee may be able to assist us in this participatim.
Sincerely yams ,
Max

PM,

24.13.

Professor of Psychiatry
Hfzkp

”V.

..

V

-

,~-

“w“.

....

-

.

--‘

v

�</text>
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                    <text>June 3, 1969
137'.

Cosmo

Ajm Mar-am

Natimal Ins'tituteﬁ of Health
Bethesda, Maryland

Dear W.

20011}

W:

Imﬂymmmdesimtommtotkmmmsof

the Cawsmdamplemitoabidebymemles, trusting
ﬁxatﬁxecmzait‘tw willbeequally judiciom forallnwbem.
The mgm "2338 Changes of the Narcotics Heroin ma
,
He'dmdone" shmld be listed with the
PM). ,
J.
Mimic,
J. Volavka, PM)” A. Zeal-cs, HA). and A. H. Freeman,
Hub.

mm

The

report “Lib

Mas of Opiate imtagmists” is wiﬂximm.

Mummmysioalﬁodeloftmmkowmseto
Mum
is witrmn.
WW
Pentattml”

I mule: like to subatimte the 611610866 abstract ”EEG
Patterns as an Index of clinical Activity of Psychoaetivn Lungs"
by ﬂax Fink, PM}. md Daniel 1%. gimpim, D.Sc. imtaad of the
report "Mtitative 2136 Analysis of mug-Induced
in

mammas in Mm" by Pink,

ﬁaﬂcyoufmyourooopamﬁm.

“inﬂating WW8.

A1th

mu: Emapim.

11:11

Wheatwishesfwa

Sincerely yams,

rm Pink,

1M).

Professor of Psychiatry

�</text>
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                    <text>.

7. ..

.77...

,

.

.7.

W

“ms

7..

...,, .

i “m: .

«vy

..~

... (3' ___,7,.,‘ m... “av-.mvn—pvmm
~

w:

hmrnm.

v. mw..~..r-w..—mu--w\

u—u-

KMVv-uw-V . w- “WWW“.

-.

.

w .~\.m-vw—~,.»v-‘—— www&gt;‘&gt;w'

‘w-v-

“a .—.,...1_.... m.

,7

.

A

”m,

.v.

m

V.

.—»-

1

i

i

E

t

E

June 2, 1969

E

l

i

I

E

S

E

E

Dr. v. G. Longo

Institute Superiore do Sanita
Viale Regina Elena 299
Rom,

Italy

Deer Enzo,

It was

a pleasure to mxk with you in Rome and Liege.
received the promsed summary of the proceedings

You have by now

E

E

E

i

l

_»

g

g

in Liege.

In our discussions with Alex, and in Liege, I was impressed
with the progress in the understmding of cmtnal neurolmnors ,
including the "Initiative" ores. For some tire I have been
particularly interested in the CNS effects of re .eted grand-—
mal convulsions (as in electroshock ﬂumpy [ECT ) when I
reviewed the available biodxemistry in 1959—60 and again in
1965 , I enpimsized dwlinergic molmisms because the data was
available; and because of my special ecperiences with anticholimrgic
drugs.

Isupposeoneomldnekeasgoodaceseforcentml
ECI’ as for dwlinergic. Perimps
the time is right for some ackiitional study, and I am taking
the liberty of sending some of w reprints in the hope that
their critique may become the basis
for dismesim.
I would be particularly pleased to have you visit New York
Bywaﬂxaninetic d'zanges in

m.

~«Mwwm‘.

.

this fall; and want to take this opportunity to them:

your hospitality.

“an

‘

‘

My

best regards .
Sincerely yours ,

rm Fink, 14.0.
Professor of Psychiatry

you

for

in».

.mwnww-‘

.

.

�</text>
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                    <text>"W",

,

Wm.

-

June 2, 1969

W

Cmter
Parkinson
New York Neurological Institute
722 West 168m

New

Street

York, Hm York

mar Dr. Yahr,
'
'
pamiwlarly interested in the
effects of peydloﬁxemqueutio drugs , notably the neumleptics;
and the EEG and behavioral effects of mticholinergic drugs.
We

leave become

‘

Ihavebeenmfezmdtoymmmter,toeekfcralistof
be available
(PIG-Search?) which

reviews
litme
from your center. If such a list is publislwd,

available

may
may I

request a

www.mlreqwstnylabomomybepiaoedmyourmiling
list?

My thmka.
Sincerely yours,
Pink.
m
Professor of Psychiatry
MOD.

Hf‘ucp

Division of Biological Psychiatry
Departmmt of Paydﬁstry

New York Medical College
5 East 102nd Street
New York, New York 10029
.

�</text>
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                    <text>mung-n

uwr-rl/v'v

a...

n

-—.w'

&lt;

m».

:vnw-

m...

v:—

June 2, 1959

ﬂW:-Ww\m‘

-

Dr. A.

(5. Copper)

Clinical Investigation

Ward

of

Medical Resend} Council
West Park Hospital
Epsom, Smey, England

mm,
Dear Alex,

It was

a pleasure to participate in the GIMP program
I believe the final program to be a.

committee with you and
well balanced one.

discussed, I an enclosing, some reprints of our BCI‘
in 19 57 - the neuroxﬂiysiologim
available biochenzical—psydmlogic
data as well as the interest in psychologie neurohumrs. The
recent observations that drugs altering brain function can
directly alter psychologic mallards-ms lend more weight to the
first part of the theory and less to the second.
As we

studies.

The hypothesis proposed
adaptive - tried to encompass the

In 1959—60 I was impressed-Mitzi; the date of the olnljnergic
neclwxism and especially by the results of my studies with anticholﬁnergic drugs. Perhaps the same results could leave been
achieved with sympathondxretics (indeed, LSD did antagonize Em‘
produced EEG slowing) but I did not study them carefully.
men no

new

reassess the

301‘

date appeared

by 1965 I submitted the draft for
enclosed. Perimps it is time to
process with as web entimsiasm es sleep, lithium

publicatim, and a

copy

is

therapy and mnomnines have received.

Sincerely yours ,
Fink, Md).
Professor of Psychiatry

Max

�</text>
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                    <text>May

Dr. Henry

29, 1969

Brill

Pilgrim State Hospital
Stanwood, New York
Dear-Henry,
Al has matched Dr. Yolles; Stan passed

to

Non:

Miller;

andIhaveadatetometNortMilleramlSidCohmon

TImday.

Ifthemammy hitcheslwill call you. Inthe
mantithavemtyetheardfrmDrJﬁmsbutwill
have
giveanymrmssage mmnday.

My

Enclosedisaoopyofnympomtobn.

best- regards.
My

W1.

best regards.
Simaemly yours ,

Fink, my.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="102929">
                    <text>May

29, 1959

Dr. Sidney Cohen

National Institute of rental Health
5451+

Wisconsin Avenue

Chevy Chase, Maryland

Deer Sid ,
Following our

dismiams of a

long acting form of

nalom,

Ihadocoasimtoepeaktorr. Waboutevieitthatl
had carpleted to the University of Mime. I suggested that
itwwldbevaluable toserdatemtoAtlmstoemdy this

years,
group of patients who have been taking marijuana for many
and to define, if poesible, the (magma of brain change which
my have occurred.

sufficiently interested to call Dr. Yolles;
the matter was referred to Dr. Filler; consequently, Dr. Miller
today suggestedthathe joinusatmmmeetingmﬂmday. I
amencloeingacopyoftheobeervatime as Importedthemto
Dr. Freedman and my menu: to him regarding a proposed project.
Time permitting, I should like to discuss a cmtrect for
amarijumastudyinAmem andacontract forthe studyof
nalomne in a eilastic vehicle to extem its duration of action.
6136' Separately, Dr. Preednm has written to you requesting
large scale study of the clinical,
m extentim for a proposed
CNS
aspects of marijuana to be mdertaken
logical and
in this laboratory.
yoreeeox. o; Lehcprgxzm
Dr. Medium was

1m

2.3.1110 II-I'D'

gruoemﬂx home '

more ens 911A bmpjeue) °
page“; euq any p6 erghmfi

to

94: 4:116 (316M (31926 pacer. 1-0qu II
a : 30 9131’ Jynmqgh (I MIN p6 mum'ﬁ was nrﬁp;
14: 3'00}? 3mm ms nigh game e pnel 110me
I 3'00}: Louver;

366211.13

DL' @3161!

hon

g;

-5-

gm sa’ Iaea

�-2-

Dr. Cohen

29,

May

1969

Itlodcslikewemayhaveabusymrrdng. Ilodcforwm

toaeeingyouatQ:30am,'nmsdq(Iwillbear-rivingﬂnnight

befmmwﬂlbostwﬁxgatmomumemwwdgaif
Wmmypmblm).
Sincerely yours ,

m
m. of Psychiatry
Professor
MOD.

1'”

M8

NPOUROIA‘

mmqumgnbecmozmﬂmmpsmw
wquwgmcmeqyuﬂcmaumozqn

one.

Weir PW use Mtg-w
1):»

In a ensure more so mam
mm
qmﬁmaam-wvmmgowm

mm'

co hon mdneemﬁ

mam: o; wagon:Lonmaquo;

33m

mbmzmﬁ’xamqmmmasowmgm

WW
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:oqskwﬂeucqmcwkwmuammﬁwm°
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ml

we must. use mgensq :0

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DL'

”171er

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madman» Dr:
:mysx.
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Mb 0; baggage tape was pew 5W £191;an wank hm'
umqpcnqnspjw
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Db“

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Imqocmmcoabesxconv
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D691

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�</text>
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                    <text>May 29 ,

1969

Dr. Norton Miller

National Institute of Mental Health
5&amp;5“ Wisconsin Avenue

Gravy Chase, Heryland

Dear Dr. Miller:

I

look forward to seeing you on Thursday homing,
to be at no. Cohen's office at 9:30 am. As I
indicated, one subject for discussion is the possibility
and expect

of developing a long acting nsloame. Mover, the principal
focus of our meeting should be the possibility of a study
at the Urdvemity of Athens to determine the central nervous
system oranges, if my, of Chronic marijuana use.
I am enclosing copies of the mport that I submitted to

mm

Bar. Freedman on my
from a visit to Athens on May 8-10,
and a
of a. proposed project. It was the latter
which was the basis of Dr. ﬁeedman's call to Dr. Yolles.
I believe that such infomatim can be gained rapidly in
such a study, not only with regard to the patimts but with
regard to cooperatim of the staff in Athens.

mom

IlookfozwaxdtoseeingyoumJuz-nes.
Sincerely yours ,
Fink, h.D.
Professor of Psychiatry

Max

Wakp

‘
&lt;
.

gins“

-..-.aw:.m...,

�</text>
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v

.‘nrr-v ......

__,.

p..lv|--.v:a«'-V~‘u(«n

v.

way-mph...-

nu». 'I'Wm/‘ "ﬂaw-Tu“ "WV

,

y

'w'Wm—&lt;

V,

._

—w-—-~

4

~...~

May

28, 1969

Dr. Strat’cm
Game 8 Stratum Inc.
381 Park Mann. South
New York, New York
Dear Dr. Strut-Cm:
A

tiny-"Av

w'x-

v'

a.“

a..
Jr“

m

nww

Ir.JowphZub1andﬂutIoemﬁmtoym
formattmﬁm.
Sinesmly yours,
Pink, NJ).

mm
Max

m .1. "WW.
.

,..,_L.

"vr-

Wu 'Fmvm“’umrwwwr

~3va

�</text>
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                    <text>28, 1969

May
"r
:.

r:

‘wz‘u—t

"aw.

1-k

w
5

Dr. Mary A. B. Brazier
Brain Research Institute

University of California Modical Gunter
Loo Angolan,

California

90024

Dear Mollie,

Enclosed is a copy of a report describing a mathematical
approach to the EEG response of pontothal. We have workod on

this for

you

in

I

many months and you may

December.

would be very

recall

grateful for your

my

discussing

comments and

‘
.

My

best regards.
Sincerely yours,

3514“"‘w’ﬁ‘u'urﬁr-ran’wr";wu

Fink, M.D.
Professor of Psychiatry

Max

v?

getf-tﬂxku,

m.”

,.-

;

”W.

.n"

.n,_

wnwmamm'ﬁ-‘m

~.-.'"‘?w‘~s.‘;

4"

“-W-I"

‘Wﬂf-Wﬂv

4275'5‘

Mszp

with

criticisms.

H..-

m-

it

�</text>
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                    <text>"ﬂaw“

w'wl'

'___¢_,_

May

‘

28, 1969

-~rv...-——W~ww&lt;-

aw,

mumv—

“WV"

““4

W"ﬂ)‘w~w‘nwﬂﬁ'ﬂl"ﬂa’ﬂuvw-‘y-erW‘WrI-r—v—ummmn-

Central
Central

Islip State Respite].

Islip, Hen

York

new Sid,

Immitingmmmﬂw.8eymmenpmis for
Wipinmmw. wmmnajoimminmmming
Ir.

Wis.

Inavemofhiawoﬁcformtiuebutmlyhmm
occasimtomthimsﬁneahejonmfmﬂty. Rial-«names
Whalmumxwdmhiamm
«retaliated, despite hm meant we. Hie interests in the
phmmlowofmtyldnlimmdotmbiogmicmat
ﬂmmlomlm‘levelmldamchprmiaeformundomtanding

mm

ofﬁmmdeofwﬁmofpsydwtiveagema,mdlrnpem
make
the work of the College.

will

sigufieam:

to

Sixwely yours ,

WWW-Jr

.V.

Mu...”

max I’

, £4.13.
Professor of Psychiatry

urn-:1

AWW'ETW!

@sz

.5._.

bcc: Dr. Bumpreis

�</text>
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                    <text>May

28, 1969

Dr. Allen P. Berger
Associate Director

Pfizer

Chase

&amp;

00., Inc.

Groton, Connecticut 06340
Dear Allen,

It is

kind of you to

make

lithium available for our

clinical trials, and an FD 1573 is enclosed for filing.
I have asked Dr. Jovan Simeon to assume responsibility for
this project, and have submitted his curriculum vitae for
filing. If you wish additional curriculum vitae's,including
my own, we will send them as well.
arrange
If the protocol is agreeable, would you please
be
should
This
tablets?
of
1.000
send
supply
an
initial
to
sufficient to get the group started.
Our

other protocol is being sent separately.
Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                  <elementText elementTextId="102935">
                    <text>May

28, 1969

8m

I». Stm'txm

Gnme 8
Inc.
381 Park Avmue South
New York, New York

Dear Dr.

Strum:

Dr. Joseph Zubin suggested

for your attentim.

that I send mesa to you

Sincerely yours ,
Pink,
m
Secretary
HFﬂcp

MOD.

�</text>
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              <elementText elementTextId="38608">
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              <elementText elementTextId="38613">
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                <elementTextContainer>
                  <elementText elementTextId="102936">
                    <text>May

28, 1959

Dr. Norman E. Pitts. Director
Department of Clinical Research

Pfizer

Chen.

&amp;

00.. Inc.

Groton. Connecticut 06340
Dear Harman,
on
I have rend the Hurstorio. Msggini and Hurri report
Subjects"
"Effects of P-3693A on the Night Sleep of Depressed
with much interest, having heard this report in Spain but failing
it all
to grasp the significance at that time. I appreciate The
report
doxepin.
the more for having our own experience with
of
sleep
with
recent reports
is good, and the data is consistent
doxepin.
with
EEG in depression and with out experience

Despite the repetitious style, the authors describe disordered
frequent awakenings
sleep among their depressive subjects ~ with
A as the principal effects.
3
and
and decrease in percent tine stages
with high dosage doxepin, within one week there is a reduction in
awakenings and an increase in deep sleep. The increase in
REM~tine is unusual, though probsbly drug related.
These changes appear drug related. The adaptation after 2
weeks is a possible problem; we would have wished some data in

weeks 4 or 5 of treatment.

discussion in relevant. The authore‘ distinctions for
doxepin from other drugs, while possibly true, is interesting and
data
reportable, but I would hove gishsdggﬁerg ggrgpggrgzsecure
be
few
to
for antidepressants and BOT. “wheaggporgopsre too
definite, although the results parallel the findinge reported
on
here for doxepin.

ﬁhﬁkb The

impressed by the dasgycoadyxanAAggsk that the dosage
be confirmed (it scene high); that if any similar data for week
should be reviewed; and what subsequent
a orwi ﬁlelxléﬂahday
studies (with dorspin or other psychoactive agents) have the

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up.

mum: make].

Key

mt.

621 Dwal

Street
Harlan

1969

33mm

mm.m1:

Wlwbesynpaﬂnticmﬂnpoaitimmﬁchyou
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Sincerely yams,

Max

Pink,

M.D.

Professor of Psychiatry
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                    <text>May

27, 1969

Dr. Joseph Zubin
722 West 168th Street
New York, New York 10032
Dear Joe,

'

be

m

Idohothmkmtomrthismquestmdlmﬂd
it dimctly or advise
mum if you wand eitherSincerely yours ,
PM

PM,

Semataxy

MOD.

�</text>
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                    <text>hay 27, 1969
Dr. Oldrich Vina:

University
Biometric Laboratory
1145 Nineteenth Street, K.W.. Room 618

The George Washington

washington, D.C. 20036
Dear Dr. Vinar:

I have read the summary of tho CINP program and find
the report accurate. May I ask, however, that the title
usudly
The word "dependence"

is
of symposium 4 be changed?
without
argument.
not applied to amphetamines or hallucinogena
and
"Pharmacological
Perhaps the title should be changed to
abuse".
and
hallucinogen
therapeutic aspects of amphetamine
I note that your secretary has misspelled the cans
of Dr. Sarwer-Fonar.
I look forward to seeing

next week.

ﬂy

best regards.

you

at the

ECDEU

meetings

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Hay 27, 1969

Dear Dick,

It was nice to receive your letter and it aoonda as if
achieved
less than you had hoped for but more than most on a
you
European visit. I had the occasion to visit Alex Koreans: in Rome
last week and hie experiences match your own.
I called Dr. Wbrtis, so you requested, for we had not
heard about your report. The volume is no longer being published,

instead the Society is issuing a new journal, Biological Psychiatry,
is to come out six times a year. The first ieaoe is now
in distribution (it was exhibited in Miami early in May). He said
that the paper has been accepted by one reviewer ("high marks") but

which

the second has not yet returned the menuaeoript.
I am sorry
that we are caught in a bind, in the issuing of a new journal. And
Joe wortia is not the most efficient of editors. I would suggest
we wait another month; and if you do not hear from him by lune 15,
I would write to him (or, better, call) asking the status again;
and if he gives you the usual doublewtalk, perhaps you should
consider publishing it elsewhere.

is foousoed

more on neloxone (how long
by increasing the
single oral dosage) and on methadone (how long does the usual
daily dose of methadone protect a patient against injected heroin).
and less on cyclexooine, although we have completed one essay on the
We are also trying
typology of patients who do well on cycleaocine.
to extend the duration of neloxone by embedding it in a plastic
polymer, like Sileetic, in the hope of achieving a 30 to 60 day treat~
Our program

can we extend the

antagonistic actions

meat.

’1 attended a meeting on peyohotropic drugs in Liege and met
a group of pharmacologist/ohemists from Sweden headed by Foxe of
Karolineka. They are doing fine work and if you do not know their
reports, perhaps you would look them up.
Keep up

the good work

!

My

beet regarde.
Sincerely yours.

�</text>
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                    <text>May 27 ,

hp. Charles Shagass

1969

Eastern Pennsylvania Psychiatric Institute
Remy Ave. and Abbottsford Rd.
Philadelphia, Pennsylvania 19129
Dear Charlie,
Al has just amnoanced that you will be lecturing on
June 6. I am very disappointed that I will not be here
as I will be attending the ECDLU investigator meetings
in Waslﬁngton.
Two

Czechs have joined my

staff

and

I

would be

for you to get to 1mm than. Dr. Jiri Roubioek and pleased
Dr. Jan
Volavka both know your work and if you have the tine, they
would be pleased to take you to lunch.

I an enclosing a copy of a report that we have just
oozpleted on pentothal. If you have a chance to read this
before your visit, perhaps you would care to discuss your
suggestions with Dr. Feldstein.
I

am

terribly sorry, but

other soon.

My

best regards.

hope

that

we

will get to see each

WW

Sincerely yours ,

r—rm

Fink, M.D.
Professor of Psychiatry

Max
mmywmvvv-w"

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Dr. Roubicek
Dr. Volavka
Dr.

Peldstein

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Ir.

Saul Roommig
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Legislative Budget Analyst
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                    <text>Dear Mr. Glickman,
The program

Medical College had

in the study of opiate addiction at the

its inception in

1960 with

New

the opening of

York

narcotic

a

treatment service at Metropolitan Hospital. Since that time, various
treatments and have been assessed, icluding psychotherapy, social
and group

therapies, therapeutic

community,

Abuse Study center was created (under the
Brotman) and

etp.

special Substance

A

direction of

Dr. Richard

this unit has studied’the sociological aspects of

substance abuse, contributing to the understanding of the typology of

addicts, the spread of addiction

A

in the schools and campuses, etc.

Beginning in 1965, a specific study program focussed on the
use of pharmacological treatments was developed, following the K/

legal

and

ethical breakthroughs initiated

by the ¢¢ pioneering

U’

of Drs. Vincemt Dole and Marie Nyswander.

We

efforts

undertook studies

of methadone, and when other substances for the treatment of opiate
WA‘AC/forzy?
4‘35”»! that ’0 j' "",
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With the

assistance of the

Commission, the City of
we

New

New

York State Narcotic Control

York and the National

have been able to assemble azgxnnpzaf

r!(&lt;.u.(ra.ﬁ

Institutes of Health

/

scientists interested in opiate

addiction and are carrying out a variety of studies.

Some

have already

been reported, and copies of those summaries are enclosed for your

informationiilht present,
a

group, and onpther
'gESnp has been

based

22

we

9

patients in our out—patient
The

out—patient
iWad-v
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limited largely by our inability to/éstablish

titles:

77

-"

35/

a community

and rehabilitation.

Ihe studies in progress

the following

60

in the in—patient center.

facility for aftercare

5LWw4 /

are treating

are—meny—aad may

be described under

of

Duration of antagonism to heroin £9 chronic oral
5?

methadone; Specificity of antagonism to heroin of naloxone; Duration

�action and

oﬂ

c
.

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r,"

linical efficacy of naloxone in/opiate addictiOH;
I

Comparison of the

CNS

effects of opiates

and

antagonists;

addicts: Significance for therapy choice in

Typology of

cyclazocine and methadone treatments
Application of tybamate in the barbituarte withdrawal syndrome
‘ﬁaﬂy—

Behavioral and

EEG

effecst of marijuana

ﬁmd7d.ocwa5M

and $3336.?

Behavioral effects of chronic marijuana use
measurable

Is there a/withdrawal

phenomenon with marijuana use

?

I trust this will be sufficient to give you an overview
of the programs. The Director sf—the-pregrams

is the Professor of

Psychiatry and Chairman of the Department, Dr. Alfred

JM

M

M.

Freedman.

M4Qp4nnkfmwu¢ian_ismthatxe£ Project Director and Director of the Division

M

.9

442111

of Biological Psychiatry/eé—éhe—Depertment*Uf—Psychtatryu——l—wéll—

enquiries, —altheugh—éf—yeu—énﬁeﬁé—ﬁewVISit
dwgyéa7-{ﬁ Zirit$‘-’M :1
“cote.
made

be pleased to answer your

W

Our—eeatery

it

would be was: useful for sash—arrangements to he

stethe—éémE‘that Dr. Freedman is available.

Sincerely yours,

ﬂee
o”...—
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9MI

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              <elementText elementTextId="38722">
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>May ‘26,

1969

Dr. Bug-m 8. PW].
Assistant Professor

You

How

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06519

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(Baum
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Wm,

Pennsylvania Psydﬁm‘ic
Abbottufom Rd"
Pamlvmin 19129).

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unampyofmm.mdl
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                    <text>J's Uw-va'rwt'evx- «mm.

‘VV—WK,"""\'W

aura-rm

—-

.v-.:

v

erm'ﬂ’lW'Il‘AvrqvnwmAm-xw'VWWrw-vnwl‘wrrﬁ'nx-Ynuww- . uv-WV—

May

——:~r.-v

,.-

1‘.

"WW "
v

cw...

run-WW...”

- v—vv

exvvv-

26, l969

V

.‘_.4_

,._.._

Dr. Barry Blackwell
Wm. S. Merrell Company
Clnclnnatl, 0hlo 452l5
The

.r.——,,....,

rev,

..

Dear Dr. Blackwell:

lt was a pleasure to dlscuss our drug evaluatlon programs
durlng the recent meetlngs of the Soclety tor Blologlcal Psychlatry.
Whlle we have undertaken many cllnlcal drug trlals In psychotlc
and neurotlc subjects, we have found these of less relevance to
our eventual appllcatlons than our EEG studles whlch show
lnterestlng predictable relatlonshlps. Untll we have exhausted
our lnterest, we are devotlng our prlnclpal cllnlcal energles
to

comblned EEG-cllnlcel
A

"w

trlals.

sample protocol and some

relevant reprints are enclosed.

”to

.v“,

“FEW.

.«mg»..,.,.

you

lf these

vlslt

methods

lnterest you,

I

would be pleased

our laboratories to discuss your compounds.

Thank you

for your Interest.

y—my—

Slncerely yours,
Kev»

Vv-I-‘T

mm

WWW:4:

aw"..-

\w

'va

vr‘l-wv.

“NH-J

m
‘

Flnk, M.D.
Professor of Psychiatry
Max

to

have

w.

.... . m-

.

..

.V

v

.n

.

�</text>
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s-r.‘

nu»... ...n-uwuw-—nm~

r-~

'nm‘v‘m

mug-r

umv—vw --—- m

May

26, l969

Dr. Maurice Dongler
Dept. Psychologle Medicaie
Ed de la Constitution i53
Liege, Belgium

'

Dear Dr. Dongler:

it

was a

Liege, and

I

pleasure to work with you in the meetings in
want, once again, to thank you for your hospitality.

sent the preposed summary of our conference
to each of the participants and asked that you send your comments
to Dr. Verdeaux for integration. i found our discussions most
interesting, not because we disagreed, for i don't believe we
disagree about the facts, but for the difference in viewpoint.
am taking the liberty of enclosing a few of my recent reprints
which review the literature of the diagnosis of mental illness
On

Friday,

i

I

using neurophysiological

criteria,

and my own efforts at
and Fink (Eds): Antlcholinergic

classification. (See also: Bradley

Hallucinogens, vol. 28, Progress in Brain Research, Elsevier,
l968.) Perhaps my view is Optimistic because i have enJoyed
the benefits of quantification of EEG and have come to discard
most of the available psychiatric studies because of inadequate
design or measurement.
i

and in

look forward
York.

New

Again,

-,
'
"

L

my

to continuing our discussions in

best personal regards.
Sincerely yours,

saws-W

:ts-rimm-nww

:

Mex

4:

wr

rymzrarrr'ﬂr

Mszp
gamjzkmf

“,3,

_.
-

'.
'.

a-zng:w.-v;rrmwrwmmn

magma.

Hun

Fink,

M.D.

Professor of Psychiatry

1;.

San Diego

�</text>
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                    <text>May

26, l969

Dr. Jerome Levlne

PsychOphermacology Research Branch
NlNH

5454 Wisconsin Ave.

Chevy Chase, Maryland

Dear

Jerry,

Since our discussion of The chlorpromezlne blood levels
and
measures, l have had an opportunlfy +0 discuss #he
proposal shortly wlfh Sam Gershon and at greefer length wllh
Dr. Julius Korein. From befh, I found the expecfaflon The?
the bgggd levels should correlate wlfh The EEG signals. This
Ian ¥9§8$8 unfounded.
8§Bec
EEG

sfudles of biodd levels and some
measure of brain function, and in each fhe correlaflons are
poor. This is usually "explalhéﬁ‘68i°+hﬁlpbaeiﬂdgohefhe
m“'Kb‘l'here have been many

in sﬂﬁdlbs El
barrier'.
if is possible to malnfeln

Héﬁfofhal anasfhesla,
a steady blood level,
EEG
shows specific sequences of changes which
and yet the
are correlafed wllh The subjecf's aneslhellc slefe and nof
with The blood level (raulconealumbsmelzm; 15: 3m, I952).
In a
of cﬂéggdlazepoxlde Whlfmen and Sfern found no
sludé r5981»
ills $5858 WNW antnnahrepol-ted
t8l'l‘8‘t3ﬁ
oﬁhdlllﬁeOEEGtehahgeughel are
laahdc‘l"52¢
'blood—breln
for example,

studyii“6l‘3a‘i‘ll

levels for
with
§¥Bhl8
b18§*
i9 fheﬁﬁlood

+

r

53'”th

a'lenfs receiving bulaperezlne.
$3oT°E§cqeiﬁﬂine, was There a
Phleptadgluﬁcmmdesem mauve

oﬂiég183%.:
mean
W
' EBBMH
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twin
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5%
(Ella ggé‘ianl‘ls‘l ko‘ﬁrgiﬁbqe

will

'lrbl’l‘d'lﬂ’llll?

W‘eTLWEEG’WIWW quﬁﬁlum
Wivewmbsmﬂe .EE0 “1993“” Mel-8 bummed

pe ;egzeq on; woe; coLelnpgA'
bee; oxboLgouco ga ena+olusq)‘

suh Loggegoue Mill pgAe so
+pe ebeC4g4goue
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Qu+gc1bg4e eye;
euq anLegA he can bLOque ¢pe EEC weeanLee'
plooq IGASIQ Ml4u pSpSAIOL suq M1;p o;peL dnou;149;ghe wegenLoe‘
monlq p6 bleeaeq 4o boL4gc1bg4e gu suo+peL a4nqh leg4gua
msA

Quq

g

3

BL. 16LOW‘3 rel/HUG

—Sa

INS-1A

‘9‘ '695

�,

.

".smwW

—,,.——....—._'....--y——~-«—..—.—w..-.——v—w.vu“,r»vrﬁ..¢_—w—7.-~..~wlv-—.,_N.V.——w

Dr. Jerome Levlne

-2—

May

“m..- {~__,,,__‘_

w

26, I969

I would be
pleased to parflclpate ln anofher study relating
blood levels wlfh behavlor and wlth other quanflfaflve measures,
and surely we can provlde The EEG measures. l anflclpafe That

expecfatlons

The

may

be

unfulfllled for blologlcal reasons (If

pas? experlence ls susfalned), and any relaflons wlll have *0
be leased out mos?

carefully.

'EEG measures were provlded
W'héWPaﬁlw
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59‘ 1595

wvw

—.

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                    <text>May

Elsevier Publishing

P.0.

Box 211

26, 1969

Co.

Amsterdam

Gentlemen:

I as writing with regard to

subscriptions to
journal,
unfortunately, may have become
confused. I have subscribed to the Journal since its
inception, and my present subscription seems to have termr
inateé with the last issue I received, that of February 1969.
The subscription was to have been paid by my College and
the

EEG

perhaps

to

my

which

this has been

two

a confusion-

I also requested a second subscription addressed

office, for the use of

my

laboratory

staff.

This

also to have been paid by the
College, has been paid, but the subscription has not yet
subscription,

which was

begun.

,

_

it be possible for somewone to check our
and send me a note which would permit me

Would

subscriptions
to establish these subscriptions:
1.

Fink, M.D..
Arleigh Road

Max

39

Great Heck,
2.

New

York 11021 U.S.A.

ﬂex Fink, M.D."

Department of Psychiatry

Rev York Medical College
5 East 102 Street
New
New

Thank you

York City 10029'
York, U.S.A.

for your efforts.
Sincerely yours,’
Max

Fink,

M.D.

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                    <text>'.’"*V~'.~

-

May

26, l969

Dr. Enoch Cellaway
Langley

Porter NeurOpsychletrlc Clinic

40l Parnassus Avenue
San Francisco,

California 94l22

Deer Noch,

This year

i

have been

particularly fortunate

in having

three resident fellows who have made outstanding contributions
to our research programs. One, Dr. Michael Taylor, is assigned
to the naval base at Oakland Naval Hospital and has asked me
to write to you, in the hope that you may assist him in continuing
his research interests. Or, lacking that, in studying with you
while in the service.
Dr. Taylor and his co-worker, Dr. Robert Levine, have
Just received the A. E. Bennett Clinical Science Award of

the Society for Biological Psychiatry for their study,
"The Interactive Effects of Maternal Schlzophrenie and
Offspring Sex". A copy is enclosed. They have continued
these studies and have more data, all of which is still
consistent!

introduced them to Reece Jones in Miami. i am asking
Dr. Taylor to call you when he arrives this summer, and l
i would be peeased for him
commend him to you most highly.
academic
in
an
career once his service is over,
to continue
and have indicated my willingness to have him rejoin my
staff if he wishes.
l

My

best regards.
Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
Mszp

—

d

thnwcthx‘

w.

P.S.

have recently completed a paper on the mathematical
analysis of the pentothel response which we have Just
sent to ScLence and which i think will interest you.

We

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                  <elementText elementTextId="105755">
                    <text>“mm...“

r.

.,:mew~uw.«

:r-w

r'

amt-"W9"

“mi-«M

«awn-r

w

“Iv—u

uv-

~~ W...

-v

1‘

r:,.‘-~-o “no"...

_.
‘V‘WV
,

.

.

, «Ur—"VW1-

_.—,,‘.H,..w-au...w

May

wu—ww

26, l969

Dr. Maurice Dongior
Dept. Psychologio Medicaio
Ed de la Constitution l53
Liege, Belgium
Dear Dr. Dongler:

pleasure to work with you in the meetings in
want, once again, to thank you for your hospitality.
Liege,
On Friday, i sent the preposed summary of our conference
that you send your comments
to oach of the participants and asked
discussions most
to Dr. Verdeaux for integration. i found our
we
interesting, not because we disagreed, for i don'tin believe
viewpoint.
disagree about the facts, but for the difference
recent
few
of
reprints
my
a
of
enclosing
i am taking the liberty
mental
of
illness
of
the
diagnosis
which review the literature
at
using neurophysiological criteria, and my own efforts
Antichoiinergic
(Eds):
Fink
and
classification. (See also: Bradley
Eisovler,
Hallucinogsns, vol. 28, Progress in Brain Research,
i have enjoyed
because
View
is optimistic
l968.) Perhaps my
discard
was a
itand
i

come to
the benefits of quantification of EEG and have
of inadequate
because
studies
most of the available psychiatric

design or measurement.
look forward
and in New York.
i

Again,

my

to continuing our discussions in

San Diego

best personal regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>n.
;

w

m-

r-vrmvm—w.u.w....,u

urn—arm

a-rsw

mun-w

g

May

26, l969

Dr. Barry Blackwell
The Wm. S. Merroll Company
Clnclnnafl, Ohlo 452l5
Dear Dr. Blackwell:

pleasure to dlscuss our drug ovaluaflon programs
recon?
moeflngs of lhe Soclofy for Blologlcal Psychlafry.
during fhe
Whlle we have underfaken many cllnlcal drug Trlals ln psychotlc
and nouroflc subjecls, we have found These of less relevance To
our eventual appllcaflons Than our EEG sfudles which show
Interesting predlcfablo relaflonshlps. Unfll we have exhausted
our lnlorosf, we are devoflng our prlnclpal cllnlcal enorgles
to comblned EEG¢¢llnlcal frlals.
l?

A

was a

sample profocol and some relevanf roprlnts are enclosed.

If fhese mefhods lnforesf you, would be pleased #0 have
vlslf our laboraforles To dlscuss your compounds.
I

you

Thank you

for your lnferesf.
Slncerely yours.
Flnk, M.D.
Professor of Psychlafry
Max

MF:kp

�</text>
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                    <text>May

25, l969

Dr. William Bunney

Clinical

CenTer

NlMH

5454 Wisconsin Ave.
Chevy Chase, Maryland
Dear Dr. Bunney:

Enclosed are The reprinTs we discussed on Friday.
enjoyed your visiT very much, and wish To congraTuiaTe
you on The fine program which you and your associaTes are
I

direcTing.
May

i

suggesT you

also

Thumb

Through The volume,

"AnTicholinerglc Hailuclnogens," vol. 28, Eisevier,
Magma in Bum Rumch, I068.
My

besT regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry
Mszp

A

y.”

A

.V,

,

pun—WU.”

cﬂwrmmu—wmp

”.1341

“urn-war

�</text>
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                    <text>Msy

25, 1969

Dear Alex,
By now you should have received my note shout my
visit to
Athens and Bro. Mites and Stefania. The remainder of my trip was
as interesting, if not meta so, than tho first part. The meetings in
Liege were exoellent, with some presentations by biochemists and
pharmacologists from scsndioovis that were relevsny to our interests.
Much of the emphasis was on dopamine and noradrenalin, however,
,and in one discussion, when I asked about the role of acetylcholino.
I was told that it was indeed important but that the absence of a

suitable biochemical assay bed limited the studios to the oeurohumors
that could be studied easily. (Thio was also stated by Dr. Eunnoy of

EIHH who

spoke

at our College this post week.)

I so still interested, however, and so taking the opportunity
to enclose coma reprints of my studies. It seams to me that the
convulsive therapy is the most specific and the best treatment of
severe depressions in men; and that the study of its central effects
should contribute so much or more to our understanding of deprassion‘
as the study of other oeurohuoors affected by imipramino and MAO inhibitors.
In my earlier review I was impressed with sostylcholine, but this
may have boon related as much to the available studios so to any
relevant theory. The same study should be applied to the other
ooutohumors, especially oorepinsphrins and dopamine.
are treating ospreseive patients with induced convulsions,
and bilateral elect rode placements. There are
significant differences in EEG and in memory effects of the two types
of treatment, and while those may be principally matters of degree rather
than kind, it does.provide tho oppoortunity to study two éiffetent
CS? psttsrns. we should be able to obtain CS? before and during the
treatuont process.
We

competing

unilateral

‘

.

Have a good time in Greece. It is possible, though remote.
that I may be back there in August. so pleaoo send me your Greek address.
If not, perhaps you will write when you return to Chicago sad we can

discuss thui further.
Agsin,

my

thaoks for your

»

hospitality.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>g

.- “" .
‘

v-

rum-w.vawmway—we'rwmqumv-Wrw

"“‘ “4."‘ '

“

.

V

,--&gt;,

‘

,

”H

"'17
r .,.

V'WWWL'WW‘FW“

23. 1969

Dear Milt,

May

Tha Program Committee

of the

1970 CIR? met

in

Roma

on

6/7 and discussed the suggestions for symposia and lectures as

presented by different delegates and members. All the suggestions
of

made by myself and the Czecha were turned down by the majority
Tha suggestion of a symposium on EEG models in
the Committee
drug evaluation was also rejectad, and no EEG program accepted.
3

The principal foci will be on neurohumors (including
alleged naurohumnrs), lithium and amphetamine addiction.
we

will

U.8.

Y

Thank you once again for considering my suggestionw~ but
have to find ancther forum. perhaps another society in the
my

E

wr-P“

'

May

P

vwvu—v—ywv—wwrw.wnun_

__

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

m!

vu'A‘AV‘JWV-iwr«mum—m..-

‘

v

‘

-

Mm: magnum-'—

�</text>
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                    <text>May

24, 1969

Dr. Eva Kellerova

Bratislava, Czechoslovakia
Dear Dr. Kellerova,

I have received the kind invitation of Dr. Formanek
to participate in the 8th Interdisciplinary Conference on the
Study of Higher Nervous Functions in Marienbad October 9~ll.
I would be pleased to participate and am prepared to discuss the

topic:

Quantitative EEG and Human Psychopharmacology:
Theory of Classification of Psychoactive Drugs

It is impossible, however, with the present limitation on the
use of 0.8. funds for foreign travel to pparticipate without
support for travel to Eurppe from the host country. If that
can be arranged, I will be pleased to participate in this
important Conference.
Thank you for your kind invitation and I look
forward to meeting you in Marienbad.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Division of Biological Psychiatry
New York Medical College
5 East 102 Street
New York City, 10029

U.S.A.

�</text>
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                    <text>i «g. u

1-

7.,

mm,

m—m-w

,-.

... ,.

qmn—~

.15..

r—Iw

«r mm.-- (.wv"
-

May

w

"wru—"'I&gt;‘anv~-:l-—xm

..l~

w, ..

.7

..

v

'«77 Wﬁ—vrver—«yvv1

24, 1969

Dr. William.Tabor

A. H. Robins Company
1407 Cummings

Richmond, Virginia
Dear

Bill,
I

have just returned from a very intereating and useful
to
Euroye to find that our studies have gone ahead. Our
trip
first patient on AER-1900 is now receiving 7.5 mg per day.
Because we are keeping the patients on a placebo period of 2
weoka, I will need an additional 10 x 50 capsules placebo for
ARR 1900. The label is attached.
As you remombor, we have maintained two

patients

on

butaperarine elixir and we would like now to transfer them
to tablets. These are not available in our formulary and
I have taken the first step for their approval. In the
uaantima, would it be possible to make 500, 5 mg tablets
available? If this request is not appropriate for your
office, should I call Mr. Corners or is there another

rapresentative

who you can have

call

on me?

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MP:kp

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                    <text>May

T0:

23, 1969

Dr. Borenstein
Dr 0 Dongle!"

Dr.
Dr.
Dr.
Dr.
Dr.
Dr.

Itil

Longo

Hellerio
Nequet

Peepiglione

Titece

Enclosed is a copy of the report of the symposium
"Experimental and Clinical EEG" in Liege. Would you

please

make any

corrections or additions which you feel
relevant citations using the same

necessary, and add

style that I did?

corrections
directly to:
The

and

citations should be sent

Dr. G. Verdeeux

Centre paychietrique Saints—Anne
LGbOtBtOira d 'EoEoGo
1, rue Cebuaie
75

Paris lee

France

that it was a great pleasure to participate
I look forward to each of you visiting
in
when
next you are in New York, hopefully
my laboratory
the
International EEG meetings in San Diego.
immediately after
You

must know

these sessions and

my

best regards.
Sincerely yours,
Fink, 24.x).
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>'II-vx'vvbwv'Vtga

.-

hay 23, 1969
Dr.

Kjell

Fuxe

Karolinoka Institute
Dept. of Histology
Solnavagen l
106 01 Stockholm 60
Sweden

Dear Dr. Fuxe:

Enclosed is a cOpy of the report of the symposium
"Experimental and Clinical BEG" in Liege. Would you

please make any corrections or additions which you feel
necessary, and add relevant citations using the same

style that I did?

The corrections
directly to:

and

citations should be sent

Dr. G. Verdeaux

Centre psychiatrique Sainte-Anne
Laboratoire d'E.E.G.
1, rue Cabanie

Paris lée

75

France

I was very much impressed with your theory of dapamine
and noradrenalin sensitive systems for the neuroleptice.
I hope I quoted
correctly.

it

For many years I have been interested in the convulsive
therapy process. Some time ago I summarized the biochemical
evidence for cholinergic mechanisms and attempted to relate
the changes in EEG and behavior to the little biochemistry
that I could find in the literature. I am taking the liberty
of enclosing a copy of that report and would like to ask your
comments regarding the following questions from your experience:

for ECT for
any of the neurohunore similar to that
which you presented for the neuroleptice?
Is there

m:
.x
-'
V

'F‘IM‘

Jewry

‘waywx

1%)»?me

““3"!”

any evidence

�May

~2—

Dr. Fuxo

Can you

recomnd

any

23, 1969

additional

workers or references regarding the
cholinergic mechanisms or other

nonrohunornl mechanisms which may be
involved in induced convulsions?
Do you have any theory of the
mechanism of convulsions from a biochemical]

pharmacological point of

I

would

like very

much

that when noxt you are in
so that I can arrange for
Many

View?

to continua our discussions and hope

New

York

that

you

will let

you to meet some of

my

no know

associates.

thanks for your participation in our seminar.

Sincerely yours.
1m Fink, 111.1).
Professor of Psychiatry
Mfzkp
‘

.

,
,

fanny-r,-

emu,

~

~v

V'ngmiﬂmuw

534491

‘1'“?

7.1;..:q,7h~,,..,

,.~,:.vv.

\
ﬁ

r

"A"

fury-r53

�</text>
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                    <text>May

23, 1969

Dr. G. Verdeaux

Centre Psychiatrique Saints-Anne

Clinique de la Faculte de Medecins
Laboratoire D'electro-encephslogrsphie
1, Rue Cabanis

Paris

XIV, France

Dear Professor Verdeaux:

It

great pleasure working with you in Liege
pleased to enclose capies of the summary report.
Following your suggestion I have only added the references
from my laboratory which I think are important and trust
that the other participants will do the same. To expedite
the integration of the various comments, I am sending the
reports directly to Drs. Borenstein. Dongier, Itil, Longo,
Mellorio, Esquet, Pampiglione and Titeca and ask them to
send their comments to you as well as their recommended
and

I

was a

am

citations.
I have also sent a copy to Dr. Pure and Randrup
asking them to send their corrections to you.

Dr. Roubicek was very pleased when I told him of our
meeting, looks forward to your visit in September, and sends
you

his best regards.

Sincerely yours,
Fink,
m
Professor of Psychiatry
MOD.

Nszp

�</text>
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                    <text>;1

i
{E

I

my 23,

1969

Dr. Axel Rendrup

Sect

Hospital

Hans

4000 Roekilde

Denmark

Dear Dr. Rnndrup:

Enclosed is a cepy of the report of the symposium
"Experimental and Clinical EEG" in Liege. Would you

make any corrections or additions which you feel
necessary, and add relevant citations using the same

please

style that I did?
The

corrections

directly to:

and

citations should be sent

Dr. G. Verdeeux

Centre paychietrique Sainte-Anne
Laboratoire d’E.E.G.
1, rue Cabanis
75

Paris

France

I

was

very

and noradrenalin
I hope I quoted

14c

much impressed

with your theory of dopamine

sensitive syntems for the neuroleptice.
it correctly.

For many years I have been interested in the convulsive
therapy process. Some time ago I summarized the biochemical
evidence for cholinergic mechanisms and attempted to relate
the changes in EEG and behavior to the little biochemistry
that I could find in the literature. I am taking the liberty
of enclosing a copy of that report and would like to ask your
comments regarding the following questions from your experience:
In there any evidence for ECT for
any of the neurohumors similar to that
which you presented for the neuroleptics?

�t

11W‘V‘ﬁwt'quﬁWxI'awa-rr

Hum/m!

‘

'-

.-'—n.'.

-2-

Dr. Randrup

Can you recommend any

May

23, 1969

additional

workers or rcforonces regarding the cholinergic
nochonismo or other nourohunoral machinisns
which may be involvod in induced convulsions?
Do you have any theory of the
mochaninn of convulsions from a biochemical]

pharmacological point of View?

and hope
to continue our discussions
know
me
let
that when next you are in New York that you ofwill
associatos.
my
meat
scan
to
for
you
so that I can arrange
Many thanks for your participation in our seminar.

I

would

likc vary

much

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkp

�</text>
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                    <text>May

23. 1969

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardaley, new York
Dear Edgar,
have an additional supply of 1m1pramine
for the ketimipramineeimipranine study. A label
is attached.
May

12 x 100

I please

Your daughter

is doing very well

important asset in our program.
Ky

and

is

becoming an

best regards.
Sincerely yours,
“83 Pink. ‘40”.
Professor of Psychiatry

Mszp

�</text>
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                    <text>. “.HV‘
..
mﬁ‘n—naqr'vr.-W’~Fthﬁ'—IIDJI\“"$WW

av.

. —.

-—er- mwm

~..: on;«Nu—(m. o. u- wv—I
,

.

May

22, 1969

Dr. Fink
Dapartuont of Pathology

Metropolitan Hospital
1901
Haw

First

York,

Avenue
York 1002.-

New

Dear Dr. Fink:

It is

obvious that no should get to know each other
I hava bean rocalving your calla and lettera,
I an aura you hora baau recalving mine. would you ploaaa
toll your oacratary that I can be roachad at 369-7900 Ext. 245
or 360-6746.
booauoa as

I

would

appraciata your calling

her where your calls can ha put.

my

aacrotary and telling

Sincaroly youra.
Fink, H.D.
Profaaaor of Psychiatry
Max

Mrskp

�</text>
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                    <text>May

22, l969

Dr. Nathan 8. Kline
Director of Research
Rockland State Hospital

Orangeburg,

New

York l0962

Deer Nate,
Thank you very much for referring Dr. Andermann
Karl worked with me at Hillside Hospital in i959-60.
I

found his work

reliable

to

me.

and useful insofar as we remained

in the category of descriptive encephalography.

Quantification
required the exercise of additional effort which he apparently,
at that time was unwilling to assert.

the ClNP met in Rome and we missed
The
dominated
sessions
were
by the basic scientists and
you.
at one point when the votes appeared to go consistently against
The Program Committee of

the clinicians (including myself) attempted to assert your
vote in addition to mine, but was turned down by the Chairman.
Part of the problem may have been the opportunity to induct
Alex Karczmar as a coworker in the Committee. The program that
I

finally unfolded is well balanced

and

i

think very good. There

will be a symposium on lithium as this seemed to be a most
important commonly accepted subject.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>w

w

:w-—-

(IIIwrﬁwﬁm‘nmwvwvvldnwv—mraa

20, l969

TO:

A. M. Freedman, M.D.

FROM:

Mo

SUBJECT:

Collaborative Project with Dre. C. Miras and C. Stefanie,
University of Athens

DATE:

May

F‘i‘nk' MOD.

'Avgr‘I-WN‘W

mﬂ-‘wmwmwhwpfmwfuir-V'IVW-w-Ir

V‘r—-

w”

-———~w

-nw~w‘

Attached is my report of the facilities at the University of
Athens. These are ideal to answer certain important public health
problems.
Do Chronic marijuana users exhibit a syndrome of
organic mental changes related to this use?

Can a withdrawal

characteristics

What

state

be Induced?
in behavior and in

What
EEG?

are

its

are the physiologic and neurophysiologic
smoking in these subjects?

effects of marijuana

relationships can be defined, and
are these related to differences in response?

What dose

Assuming radioactive THC may be used in man,
what is its distribution and fate in human
tissues, compared to available animal Species?
in View of the active Public Health and Department of Justice interests
in marijuana, it may be appropriate to undertake a pilot study this
summer. Funding for a trial would include:

�.W

rwwhmw-WVWv-u-

-

W‘Plvr»

Dr. Freedman

~2—

Personnel

May

Supplies

U. S.

Psychiatrist

Greek

Psychiatrist

(SIBOOO/yr.)

5

20, i969

Salary

Travel

-

$I000

2,500

Maintenance
$

800

~

—

Laboratory Support
‘

Chemistry ($2000/mo)

$4000

-

—

-

(SiOOO/mo.)

52000

~

—

-

EEG

Travel: Additional for
2 American Supervisors

$2000

Volunteer fees

$l000

Telephong! cable

S

300

$7000

contract request

5

2500

$3000

S

800

be negotiated with the NINH (Dr. Yoiles);
and failing that, the Federal Bureau of Narcotics and Dangerous Drugs, the
Ford Foundation or the Foundation's Fund for Research in Psychiatry. Since
an NiM‘i contract is more likely, i would suggest we call first, then write
to Dr. Yoiios promptly.
Such a

may

This'hontract" is best presented separately from the proposed Kaéler-typo
application, although collaboration with Dr. eras should be included in that
application. This may present special problems and could best be handled
as a separate, concurrent application, possibly even one submitted through
the international Association for Psychiatric Research, which may be more
flexible in its fund management than the College.
Mszp

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                    <text>any 19, 1969

Editor

Psychosomatico

Irvingtan,

Dear

ﬂew

Jeraay

Sir,

Enclosed are the carrcctad gallay proofs at our articlu
rgvtewing the alinical 3nd EEG effects of Doxapin. Tha dcl‘y in
their return insulted fro: my being nuly in Europe, und I trust that
tbs corrections may yet be undo.

Please revise aha 11:: of authors as indicated.

Sincltcly yours,

Fink. H.D.
Profeanot of Psychiatry

Max

mf/

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                    <text>Krm—w—tw.—

May

i9, i969

Miss Ellen Kaplan
E. R. Squibb &amp; Sons, Inc.
909 Third Avenue
New York, New York l0022
Dear Miss Kaplan:

in rereading This summary,

l

became concerned

lbs?

it

The Topics were covered in a haphazard manner, making
difficult for The reader. l have had fhe paragraphs re~

constifufed,
i

am

and

frusf fhaf This is heifer.

assuming you will add fha approprlafe references.

Am i corrocf in assuming also fhaf you will publlsh
tho compiefe reporf of our studies, submlifed under The
Title "Depot Fluphenazine in fho Treafmonf of Psychosis

in a Communify Menfal Health Clinic," by Luigi Bucci, M.D..
Marla Fuchs, M.D., Jovan Simeon, M.D. and Max Fink, M.D.?

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

enc .

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WW

WW.

"W

May

l9, l968

Dr. w. Keup

Dlrecfor of Research
Brooklyn Sfafe Hosplfal

Research Faclllfy
68l Clarkson Avenue
Brooklyn, New York ll203
Dear Dr. Keup:
Thank you for your kind lnvlfaflon fo parTlclpafa ln fho
l969 annual meeflng of fhe EPRA. I would be pleased to review
The EEG effects of varlous halluclnogens, proposing a
classlflcaflon based on the central neurophyslology. An

approxlaale

flfle ls

"Neurophysiology of Halluclnogens

~

Sympathomlmeflc, Antichollnerglc and Oplalo", and wlll besf

ill

ln secflon Sb-c.

I

would Ilka

to propose the followlng partlclpanfs for

your conslderaflon:

I. Dr.

lfll:

3c,

3d

3. Dr. Arfhur Zaks: 39
4. Dr. Jan Volavka: lc
Thank you

for your lnvlfatoon.
Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MFskp

�</text>
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                    <text>May

l9, i969

Mrs. Frances Nyberg

Assistant to the Director

American Medical Association
535 North Dearborn Street

Chicago,

lllinois 606l0

Dear Mrs. Nyborg:

Dr. Rosnick is a member of the staff and devotes 2/3
his time to our teaching and research programs. it is not
possible for us to insist that any member of the staff be
affiliated with any organization, and therefore hesitate to
give this message to him.

-

.

Please do whatever is consistent with your rules, including
and we will accept the outcome.

dellsting Dr. Rosnick,
‘Wﬂwm‘ﬁw‘vlwwmrQ1Wm4wm-‘J‘.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
wr-Wm-

‘1

,

m

Mszp

�</text>
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“7v

4'

»-‘.rv~v-;“-.. ,_ Iu'w~4'-’r ——.W,. «a»... NN..n‘V»m..—-.r.,.wmmr—wmm‘...

TO:

Mr. Schwarfz

FROM:

Dr. Fink

v.3...wm-..

‘.‘.._.._.v..._

ﬁn.“ "w.“

”\wauwr ..

DATE:

..

V,

.,

n...

‘

.

.

May

m,

.. 7,...

19,

SUBJECT:

I.

concur in Ken Skrlvanak's recommendafions wITh
regard to fhe Division of PsychOpharmacology.
How

I

are fhese

+0 be implemented?

2. Can Tradeaoff an office af Mef for The one
usad 3+ £02nd Sfreef?
I

Mszp

Ken

,

IQCQ

�</text>
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                    <text>T0:

Mr. K. Skrlvanek

FROM:

Dr.

Max

DATE:

May

19, 1969

Fink

SUBJECT:
.v'.wu~w—

Nvm—‘V—m-W‘WI’WTIWW-"T

rm...

is wtfh greaf regref The? received a cepy of your
of
laffer
restgnaflon. Your associaflon with This Dtvislon since
your appointmenf Two years ago has been 3 mos? useful and pleasant
one for me, and The pafients and sfaff have beneflffed from your
in?eres+ and enfhuslasm.
IT

My

,.._

hes? wishes In your

of Mental Hyg!ene.

sum-W

w-v-Vrv‘vu,

I

MF:kp

new

poslflon wlfh

The Deparfmenf

�</text>
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                    <text>May

18, 1969

Dear Carl,

have no objection to the circulation to other ECDEU
invastigatoro of the demography data of our studies. Some weeks ago.
however, in anticipation of this meeting, I asked Dr. Simeon to
update the recorda of all our studies, and these revised forms were
cant to Dr. Guy. we would prefer to have the corrected listing
presented, if at all possible.
We

1

look forward to seeing you in June.

Sincerely yours,

Max

Fink, N.D.

Professor of Psychiatry

mf/

�</text>
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                  <elementText elementTextId="102966">
                    <text>..

uwn "w w

—'

wwvvz-

smwv

~

—--

1w

,mea-vv-

H'L-ﬁu‘s-Rﬁr:

-u.'1u—)Ir-» .|

vn-n“ mvmrwmzmmz-v-wwx wr-Wm K‘C,'&gt;~I!4‘_“

Dr.

um

Fritz Freyhan

New

York.

mus-news

5,

I

'W.‘"w1“"'l—'

Wam'\nv.

,

"rrww um.- a'wru—ruu-v

w evv war» '

‘Ilv‘

mea' 97"

1969

St. Vincent's Hospital
153 West 11th Street
Dear

New

York 10011

Fritz.

for the
suggestions are pencilled in
novel approaches or data.

My

The program format

APPA

and

is quite satisfactory.
reflect opinions as to

Robins probably presents a more general overview than

Ninokur.

For discussion of neurophysiology, both Perez-Reyes
relevant and novel data than Gershon.

and Bnyder have more

For an overview. Roth and possibly Dewhurst have more active
interests and relevant data than Grinker.
The meeting
My

place is shifted to the

New

York

Hilton.

best regards.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry
and Secretary

Max

xi."

—_.

ran

May

‘4’“

--v

'

Mszp

.ﬂ

,

,

�</text>
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                    <text>Kay

1. 1969

Dr. Ra Pa “nickel
Aaaoctaca Proton-or of Pharaacology
Laboratory of Payehopharuacology

Indiana Untvaraity
Paychology Building
Bloc-ington. Indiana 67401
Dear Dr. Haickalx

Thank you vary such for your invitation to aarva on the
Board of Con-ulting lditora for tha Jouanal 06 Behaulonal
9y. If I can ha of any halp in launching your

purpoaad nan journal,

1

will ba plaaaad.

Goad 193k.

Sincaraly youra,

“I! Pink,

Hana

Profaaaor of Psychiatry

Hrtkp

�</text>
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                    <text>F11!
u

‘mm-rvl‘v- 17" :‘omil‘

. w
Y-mewi'lw' ”I ”mud“:
.

“"7
.

,

,

.,

,_

,

rat-e

,

vw-r,

mwm..~5-uxm—.wmw

yawn:n..w.-a-nn:.-wurm,«—

A‘erv-l

(212) 359-7900 Ext. 245

Mey

1, 1969

Dr. Sanghee Park
Wright Trailer Park

Rt.

A

Chapel

Hill, North Cerolina

27514

Dear Dr. Perk:

Dr. Freedman has been referred to me
please send me a copy of your curriculum
for reply.
vitae? 0n the occasion of your next visit to New York, please
Your

write

and

letter to

Would you

I will try to arrange

an

interview.

Sincerely yours,
Fink. MOD.
Professor of Psychiatry

M88

Hrzkp

cm?

m...

“$5”wa

W.

,

yawn",

unwww

prod-I'v—

�</text>
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wmmv—rv'l'v"

W

May

1, 1969

Dr. Marossa H. Orzcck
Boston University School of Hcdicine

Division of Psychiatry
80 East Concord Sttcet

Boston, Massachusetts 02118
Dear Dr. Orcack:

I look forward to caning you on the afternoon of May 21.
If that is unsatisfactory, MOnday, May 26. Please come to
my office at 5 East 102nd Street, 8th floor, room 42, at 2 pm.
call

If there is

my

any

difficulty with

secretary at (212)

any of these
369-7900 Ext. 245.

dates, please

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

MFskp

�</text>
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                    <text>May

1, 1969

Dr. R. P. Mbickel

Associate Professor of Pharmacology
Laboratory of Psychopharuacology
Indiana University
Psychology Building
Bloomington, Indiana #7401
Dear Dr. Maickel:
Thank you very ouch for your invitation to serve on the
Board of Consulting Editors for the Joulnal 06 Behavional
PhaAMacotogy. If I can be of any help in launching your

purpoaad new journal, I
Good

will be pleased.

luck.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFskp

�</text>
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                    <text>August 29, 1969

Dieter Bente
Universitat3~Nervenklinik
Dr.

Schwabachanlage 10

Erlangen, Germany
Dear Dieter:

is our

letter.
though
I had not heard from you, I anticipate
that
will
you
he in the States for the EEG meetings. I look forward
to seeing you in San Diego and, in View of your
extensive experience in EEG and psychiatry, I would
be delighted if you could Join us.
My best regards.
Sincerely yours,
Enclosed

follow—up

Max

Fink,

Even

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>re

a..- 1.."

mas—u.—
,

"mm-W...”“m" :,

WW...

4vw—v '1"‘WVW1"H&gt;
i

1 :r. um ,_,»¢-

.u.

"WINK“Zhuuwn'ﬂmv—n-vwnvi
~~1wtcn¢ ...... «wavy-wane
4

.

.-—n ,
,

n... ..

,

..w .,:-» -

Ww'

rm sunmgv

w...-

u...» ”nun,“

.,., . _,_, ,, "nu-ww- vw.

1

,,

7v:

,-

WWI

v&lt;vugmvvzvu~m

i

:

T0:
FROM:

Adsinistration,

New Community

Metropolitan Hospital

Fink, M.D., Professor of Psychiatry

Max

SUBJECT:

Hental Health Center,

EEG LABORATORY

- Metropolitan Hospital

DATE:

8/29/69

mental Health Center

The development of a Community Mental Health Center

requires

the application of the best available methods of diagnosis and
treatment to reduce the time for treatment and improve the results of

interventions.

Based on

this premise, the Center is required to

have a diversity of services.
During the past decade, the role of brain function in mental
illness has assumed a greater interest and techniques measuring
and
changes in brain function have found application in diagnosis
management. The changes in brain function are measured principally
by psychological performance
Much
EEG

research has been done

analysis are

now

tests and by the scalp recorded EEG.
and clinical applications of quantitative

available in a

few medical

centers. In our Department,

analysis is available for research purposes,
has been limited by contracts to patients in the Narcotic
Addiction units and the Psychophsrnacology Clinic.

quantitative

The

EEG

and

clinical applications include:
1. Diagnosis of therapy resistant psychosis.
2.

Determination of adequate levels of antagonists in

the treatment of heroin addiction.
3.

Classification of brain injured children in the
Mental Health Clinic.

4.

Selection of drug therapy in psychotics.

..‘..‘-..... --- -

�"nu-rm
If the

m m,‘- ”mi—,ﬁﬂwmlw"
‘sw

.

equipment were available,

these lethods to

we

propose to apply

all pstients adnitted to the

Mental Health

Center, and for selected out-patients referred by the

staff.

Steffing funds already exist in the clinical staffing contrscts
available to the Department.
The

techniques used require careful recording of the

brain waves, storage
and

reporting.

The

tape, analyses by special programs,
individual pieces of equipment and their
on

functions are:
Electroencephalograph (Grass 78) and Couch: Used to
amplify brain waves.

The Grass

instrument provides signals

specially suitable for analysis since they
"chapper" type amplifier.

(The

do

not use

3

Offner, Medcraft, Gilson

units, although cheaper, are unsuitable).
Tape recorder (Ampex SP 300).

configuration, 1/2 inch tape.
analysis.

While Anpex

Seven channel,

Used to

FM—IRIG

store signals for

is reliable, other

vendors

may

be used,

as Sengemo, Honeywell.

Oscillator (Hewlett-Packard

2026K).

To

provide s standard

for tape units, especially for amplitude comparisons.

.-n»r.—--mv.w~-———.-~way—Fwwvuw‘

�“yaw-"T

-

I

A

.,m'—

A

V

my..."r.rwmmmMW—wqw—uuvww-«m-w—.m

vwn-a—Wn

&lt;w—w-w--—.—w-u~

wry—v»

Oscilloscope (Toktronix RH 564. dual channel). Monitors
the recordings on tape. Either single or dual been are satisfactory.
A

store's

scope

is necessary to allow its use also for photographs

of the analysed output.
IBM

1800 Process

power and amplitude

but

much

Controller. Analyzes

EEG

waves by

analysis. Other instruments are available,

less efficient. This device. though expensive, is

the one for which a library of programs has been written and
can be used immediately.

flexible

and

completed in

require
2

Other computer systems would be less

programming.

(Our programming has been

1/2 years.)

wm-w

w-vw

-r-

-1"

period,

Respectfully Submitted,
Fink, M.D.
Professor of Psychiatry
Max

�m"—

V

_

V

.1-I»'

“—3.2".

-

u-mv—nmz‘w—

EQUIPMENT FOR EEG RECORDING

Grass Instrunsnts
Quincy. Massachusotts

Roo- 4-17

1

console 7816p43.75 with 763800A-1230-16P

1

power supply 67RPS-A

1

Signal markers
8

HT7A

885.00

$

800.00
($165

as.)

botwson channels

and 9

165.00

8

Oscillogrsphs 6080 ($140 as.) with 1" spscing

8

830 Data

1

78MPRr8

1

678525-12 canneric pushbutton electrode

1

78THIEB ZO-N

amplifiers

1120.00

7P511A

3200.00

Master record playback

150.00

w”

,,

v—r-ﬂmrwzmyw—v

selector

400.00

high impedance electrodo board,

300.00

standard numeric

,_

--..

TOTAL $

.‘t-w-I-v-VWW'gw-vm‘

7020.00

.WA7F_

~._-_-w—w,&lt;

Room
1

.mrw..v~.—

é~17
Anpcx Modal SP-300 Record/Reproduce

1/2" wide tale,

»

7

track,

7

portable,

amplifiers

1

Mbdcl 704 Head degsnssor

l

Rsnotc control table top unit plus 30'

:Wwwm‘

8450.00

$

9.95
74.00

w

.-

cable Cat 596520-01

mum

&amp;

#4050100-10

-

m"

W1

TOTAL

—-

mmwm_mnmmlmww'r

1

Tcktronix dual bosn OscilloscOpe

1

Hewlett Packard Oscillator,

1

Inwood Couch H-4900, antique white (Scully Wslton)

RM

564,3A72, 2367

ZOZCR

$

8533.95
1250.00
330.00
144.00

�EQUIPMENT FOR

886 ANALYSIS

-u-———w—-

4-22

BOOM
~m-a-

rr'

may

.7,

.

One

rm...

-

IBM

1800 Process control system consisting

of:

m

WW

lSOl-Zcb

Processor controller

1816—1

Printer-keyboard

1828-2

Enclosure

1851-1

Mnliplex terminal

1856—1

Analog output terminal

23lO-A2

disc storage

1442—6

Card~read~punch

1443—1

Printer

Coat, single:

Approximately $168,000.

ZRWW”W"'

13w";-

rv-

”Ev-WW"

rwuwwrr-rv

m—u-wr-rpm

gwm

(For detailed specifications, ploace

call

Dr. Max Pink or

Dr. Donald Shapiro, New York medical College;
IBM,

or,

475 Northern Blvd., Great Neck, New York.)

Dr. Wayne

Joatrand,

�</text>
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                  <elementText elementTextId="102973">
                    <text>August 28, 1969
Miss Eleanor E.

Carroll

Acting Chief
Center for Studies of Narcotic
and Drug Abuse
National Institute of Mental Health
5&amp;5“ Wisconsin Avenue
Chevy Chase, Maryland 20015

Carroll:

Dear Miss

questions of August 25 are most interesting, and
I can answer immediately.
I use cannabis as the general term for the plant species
and products to include marijuana, hashish, and themr extracts,
as the cannabinols. In a broad sense, the word can also "cover"
the synthesized tetrahydrocannabinols, if we assume these to be
related to the active principle of the plant.
1. Strength of cannabis. Two problems are involved ~
the cannabis used by the subjects for years, and their present
samples. Dr. Miras has assayed samples for some years now add
we will depend on his estimates of the quality available
of the subject's
historically. I expect that direct doassays know
be
done. I
not
present materials will
if a history of
cannabis quality during these decades can be compiled, but we
can attempt this. I will being your question to Dr. Miras'
some

Your

attention.

Definition of "Chronic". In Dr. Miras classification,
we are focussing on the B, 8-0 and C groups. The initial step in
the project is to identify the population and assess their reports
of cannabis use. The subjects introduced to me claimed daily
hashish use since their early adulthood, approximately 20-30
years. We will examine as many as we can and report their statements. "Chronic" will be defined by these records.
3. Sample size. Dr. Miras speaks of 200-300/subjects
in Athens. We would survey as many as we can, and study in
2.

detail 30-40.

�Miss

Carroll

August 28, 1969

~2—

Drug use forms. I will write to Dr. Miras
requesting a copycf his form. The DCMH form and our cannabis
inventory (derived from Haertzen) are enclosed.
Dr. Miras' classification does have "overlap", and he
emphasizes the fluidity of subject's use, allowing him to
classify subjects as A/B or B/C. Perhaps we will be able
to define these classes more satisfactorily. I expect it
to be difficult since it is likely that the reports by each
subject will fluctuate widely depending on their trust in us.
Our experience with Opiate addicts may be useful - for we
usually disregard the reports given initially, and depend

u.

more on

their later reports.
5.

Sibs and family members.

Yes.

Vilunteers. We wish to bring some subjects into
the hospital for testing; allow them to smoke their products;
and examine them for 2h~48 hours (or longer) thereafter. To
induce their cooperation, we will pay them for lost income pﬁus
a bonus for volunteering (plus, on occasion, money to buy their
hashish in quantity sufficient for trials and for assay). If
we get 30 subjects, it averages $100/subJect. This may be too
high, but we can report our exact costs and return any balance
6.

of the requested amount.

"Hashish'. In my initial interviews, I was
men claimed nbt to use alcohol or opiates.
We are interested in drug "associations" and
synergistic uses and will inquire, not only for their present use, but their
historical use as well.
8. Anthropological, Sociological Consultation.
This is a defect in the present proposal which may be remedied.
I am asking Dr. Feldstein to make the first examinations, and
he is aware of this issue. I have written to Dr. Miras about
this question, and he has yet to answer. You will note I
request funds for 2 consultants, and have named only one
(A. M. Freedman). I would like to consider, once our initial
data is collected, to ask Richard Brotman of the New York
Medical College to assist us.
Some forms are enclosed. The rest will follow as received.
Sincerely yours,
7.

impressed that the

Fink, M.D.
Professor of Psychiatry

'Max

Mszp

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                    <text>August 27 , 1969

TOWITWCORW:
Fonmingtherequestofl‘b. J.

W.

StanciloftheBoard

of Veterans Appeals to Dean J. P. Eagle, Nov York Medical College,
the record of T. B. anday, C-‘W62879 was received for review
on 8/21/69. The record consists of depositions, military record
and

letters to

w:

and

has

V.A. claims

offices.

at the age of 30.
visual acuity defect, correctable to 20/1“).
Ming military service training, he claims to have suffered
a. fall on 5122/“, breddng his glasses, He was di
in June, 19m, A pension was wood, which on review 19“?
it»

Exaninat on showed

Monday enlis- ted 3/11/Im
a.

wasdeenedtobeinemcr, andmscirded,asthedisability
not service-mooted.

was viewed as

Claim: Progressive visual defect, aggravated by military
service, and yielding a state now of virtual "blindness".

ions: Mpsyohistricquestions misedbytimmﬁner,

Wmﬁmbasisofthemcord,mz

to

and

1. Does the veteran have a functional visual defect?
Diagnosis?

g3.

Data:

status.

Be

probable that it advanced during military
itservice
(19%)?

5.

Is

u.

Istheoowseofthedisozﬁermthanwmld
beacpected?

The record

is

is alleged to

have managed a fwnily type
Only one

sparse with regard to psychiatric

have completed hiya school; and

retail store prior to service.

psychiatric emiration

was found, dated

to

3/25/69, from the V.A. Center, Mountain Hone. Johnson City,
Tennessee: "...except for the possibility of fmctional
visual defect, he shows no recognizable evidence of mumsis

at this time."

�-2The depositions

present a

mixed

picture - loyal friends

citizens alleging severe interfermce with vision since
191m; entertainers finding a dissociation between his behavior
(in store, street, daily affairs) and the mninations, which

and

severe

show

bilateral acuity loss.

inion. The record presents no evidence for a hysterical ’
dissoEEEE’
state, and lends itself to the interpretation
that acting-out ("malingering") for secondary gain is likely.
of a detailed psychiatric exanination which
such
supports
a diagnosis takes the following opinions temnus.
The absence

l. 'Iheclaimantmyhaveafmctionaldisorder20
wiﬂxcm:

its rapid onset in

lean and persistence for
years
outward evidence of organic progressim are supporting evidence.
2. A psychiatric diagnosis is not possible on this
record; altlwugm psychosis, as camrticnnlly defined, is
mlikely. The absmce of evidence of neurosis, makes malingerdng
as well as an organic state more likely.

psychiatric state could have been precipitated
daring military service. 'Ihe very natme of the stresses of
service, the unconscious wishes to escape, the acceptance by
society of physical disorder as justification for military failure,
3.

A

andcoupensaticnlmsermanceandsupportthedevelcpmntof
corzversim pimmena and malingering. In addition, the
culture franwhioh Mr. Norway derives, may invest such in a
credible, aggressive military service; and Mr. Monday's apparent
"failure" could be excised, if it were mdically derived.

detemination of the presence of a conversion reaction or
"nialjngering" shmld be made by a psychiatric eminatim dedicated
to such a determination. The record by P. A. Vesey (3—25-69) is
béirtcaxplete for this determination, and a more detailed study may
A

advisable.
1+.

Thecomsecfthedisorderismtmusualfor

conversion reactions or mslingsring. , occurring in situations
where secondary gains are derived fron the conﬁrmation of the
disorder ~ as is possible in this instance.

I an Professor of Psychiatry,

New

York Medical College,

York University College of Medicine, 19%;
mediated from the
licensed to practice medicine in New York and Missouri; and a
diplomats in neurology and psychiatry of the American Board of
New

Psychiatry and Neurology.

Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

a as;

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                    <text>mwvsr-kuw—wﬂ

7...“,

v-v—nv

-.-r,,~.wv‘,....._..v.r,....

.

.,.,

August 26, 1969
Mr. Herman Heisman
Hoffman La Roche. Inc.

Nutley,

New

Jersey

Dear Mr. Heisman:
a pleasure to have you and Mr. Billig visit my
laboratory last week. The questions you raised, whether
objective drug specific patterns can be defined for Librium
is challenging. Specifically. you asked whether neurophysiologic

It was

indices could distinguish Librium (in therapeutic dosages)
from barbiturates (e.
phenobarbital)? Your reference to
..
define
su
to
failures
patterns in prior animal studies suggests
the difficulty of the problem.
There is some evidence that such a discrimination
feasible through quantitative EEG measures.

may

be

quantitative EEG studies of anesthetics, Belleville
in
specific responses for different anesthetic
Studies of amobarbital by
the
barbiturates
agents, including
1.

1n

1956 showed frequency

Shagass and of pentothal by Goldman and ltil showed frequency
specific curves for these compounds in mentally ill subjects.

2. Recent quantitative studies of pentothal developed
mathematical
a
expression for the EEG response (see enclosed).
This curve differed in patients receiving a phenothiazine from
those receiving placebo, suggesting that drug interaction in
the CNS may have altered the parameters of the expression.

profiles of Librium and Valium are similar
In our study of diazepam, imipramine and
placebo. our techniques classified diazepam. and this pattern
dhffered from imipramine.
3.

The EEG

to barbiturates.

techniques used in these studies represent the
available
best
today. In addition, instead of using a period
model. the more refined power spectrum
reduction
data
analysis
could be applied for greater resolution. Using power spectrum
as a back-up, I believe it should be possible to define EEG
profiles in volunteers. This could be attempted with either
oral or intravenous preparations. Two courses are suggested.
The EEG

�-2-

Mr. Heisman

l.

August 26, 1969

Oral study.

In an oral study, the changes in EEG may be defined
during l~3 hours post-drug using a period~analysis model.- The
first step would be a definition of “equivalent" oral dosages of
chlordiazepoxide and a barbiturate.x The equivalence may be defined
from the literature or in a pilot
byu33havioral criteria, either
s

.

In a definitive study. volunteers would return for 3-4
sessions. to receive in random sequence chlordiazepoxide placebo - barbiturate; and a second dose of chlordiazepoxide
or barbiturate. Data analysis would follow established univariate
(t-tests) for each variable at different times; or, a discriminant
fonction approach for split samoles ~ using l/2 the sample to
define the beta-weights and verification in the second half of

the sample.
2.

Intravenous study.
These techniques are more adequately

tested.

The

mathematical expression for pentothal has already been defined.

study of the

changes in volunteers receiving intravenous
would allow verification
of the pentothal curve. and a statement of the parameters of the

A

EEG

pentothal, chlordiazepoxide or saline
chlordiazepoxide effect.

Either study could

later this fall.

The

be undertaken in these laboratories
questions you raise are of theoretic

as well as practical significance.

studies

have been undertaken.

In

knowledge, no such
because EEG quantitative

To my

part.

techniques before 1963 were too inexact and unstable to be useful
for the fine discriminations required by your question.
Thank you

for the opportunity to review this question.
Sincerely yours .
Fink, H.D.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>my \v—n—w-muwy

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Augult 25, 1969
Mr. T.

J. Israel, Jr.

Vandcn Brooch, Licbcr &amp; Cal
125 Maiden Lane
Now York, New York 10038
Dear Tod,
would you please confirm directly to our auditors,
Pancth, Hubs: and Zimnorunn, 135 East 42nd Stroot, New
York, How York 10017, the following information as of

June 30, 1969:

1. Security position,
2.

My

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Any

if

any.

fund: due you and due us.

Ito-pod oclf~addrloood envelope

your conviouco.

is enclosed for

,,__........

Sincerely yours,
Mu rink, NJ).

Exlcutivo Director

HFskp

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                    <text>August 25. 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Dr. Harrison:
Our initial trials with GP 41,299 have progressed well.
In 15 trisls in nor-a1 volunteers, we have used dosages of
25 to 200 mg. The observation period of EEG and behavior
has been 1 1/2 hours. we have also obtained the subject's
reports of the succeeding lé—Zh hours.
and

for

day.

behavioral effects of sedation, drowsiness
100 33. These symptoms persist
hours. the subjects reporting sleeping late the next

we have observed

lsssitude at dosages over

many

The EEG changes

are defined as increased theta and some
and a decrease in amplitudes.

delta; reduced beta activity;

These preliminary data are insufficient to classify 6? 41,299
but do provide the basis for the second phase study as outlined
in our protocol. Before undertaking this study. however, I an
anxious to check s few records at a longer time period (4 hours).
As soon as these trials are completed, I will send you a revised
part 2 of the protocol.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Hrzkp

�</text>
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                    <text>August 25. 1969

Dr. Turin E. 1:11

Missouri Institute of Eoychdntry
5400 Axlonal Street
St. Louis, ”issuer:

Boar

63139

futon.

Ht have cooplotod our phaao I study of pyrovalorono.
rho conclusions arc summarizod 1n the enclosed report, aunt
to Dr. Boyer. the EEG macorlnl shows pyrovalorone to havo a

,.

,

wwgyxwu

umwvw—z—e—w—av

pattern similar to tho anphotaninos. but
deflnlttvo study.

must depend on a

its classification

An wo had discuased in Hiaml. I am oloo sanding a copy
to curl Pfeiffar. If a collaborative clnnaiilcation study
wore dons wn would rooiunond clnslo 160 as dosages. and
other conditions, as describod on page 5.
‘

—

Hy

but: regoxda.
Sincerely yours.

-mwn

x
-

HI!

’1“.

”OD.

Profoaaor of Psychiatry

Misty

cc: Dr. Boyer

�</text>
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..

,.

:w-z

-

nm‘d"-’:‘,K‘.mmev:uu:v.~vamy ,- falan' “um

m—

wow‘

—

I.

m

"J‘ -.”maﬁa-urnzvavwr. (.73.... r
.

.

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7..

7,.

August 25, 1969
Dr. Philip A. Boyer,

Jr.

Motion Laboratories. Inc.
10236 Bunker Ridge Road
Kansas City, Missouri 64137
Dear Dr. Boyer:

is the ounnary of the pilot pyrovaleroue ~
EEG study in volunteers. The data is sufficiently clear
to answer the questions set for this study, 1.e., behavioral
and EEG affects aro readily apparent at 160 mg pyrovalerone
(single dose) in normal, adult volunteers; and that this dose
Enclosed

is safe

and

well tolerated.

I have sent a copy to Drs. Itil and Pfaiffer, as I had
promised in our initial discussions in Miami in December.
any

After reading this summary, would you call

additional data
my

you may

me

regarding

require for your records.

boat regards.
Sinceruly yours,
I'm Fink. 14.3).
Professor of Psychiatry

Hrakp

one.

“,3.

._v

v,“

A.

7...... ...

»...

.1...

r...

.

.3.“

5.

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�</text>
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                    <text>August 25, 1969
Dr. Carl C.
new Jersey
Box 1000

Princeton,

Pfeiffer

Neuro~Psyehistric Institute
New

Jersey

Dear Carl,

-

EEG
You may recall our discussion of pyrovslerone
and
a
in Miami. 1 undertook the single dose~pilor study,
This
information.
for
enclosed
your
is
summary
preliminary

study followed our usual procedures, to define a minimsl
end/or EEG
effective drug dose which elicits behavioral
EEG
changes in the time period of our usual EEGstudies. The
profile study.
data is sufficient to allow s definitive
Copies of this summary have been sent to Turen Itil
end to Dr. Boyer of Nsrion storstories.
Trust you have had e healthy and relaxing summer.
My

best rugsrds.
Sincerely yours,
HI: Fink. MJ).
Professor of Psychiatry

ﬁrzkp
Cm.

�</text>
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                    <text>August 25. l969
Dr. ii. J. Russell Taylor
American Medical Association

Clinical Pharmacology-Toxicology Center
Philadelphia General Hospital
Philadelphia, Pennsylvania l9l04
Dear Dr. Taylor:

Enclosed is a draft copy of our report to the A.M.A. on
July 14. It represents a distillation of our experiences with
the antagonists oyclazocine,and naloxone. and with tybamato
and methadone. The data is not original. and it should be
considered for what it is - a summary of experience and
published reports. Thus, publication as a special summary
may be appropriate; but not as an original article.

It was a pleasure to participate in the symposium. I
also pleased to read that the AMA voted to allow specialty
sections to continue responsibility for the meetings. This
should stimulate better programs.

was

My

regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
BBC.

�</text>
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                    <text>August 25. 1969
Br. Barbara 8. Brown

Chiof. Exporinaotal Phyaiology
Vatarana Administration Hoapital
Bapulvada, California 91343
Boar Barbara,

I had already anaworad tho firat call for intaroatad
participants in the "Foadback Society," but van ploaaad to
receive your lattar. I think tho idaa ia a good ona particalarly in EEG. whore tachnical breakthrougha have
ovarahadovad concoptual. The faadbaok nodal to vary intaraating
to no (Stan Paldatain, J. Volavka and ayaol!) and while
wo hava not approached tho EEG from thia point of View,
we have made one aoaay in a machaoical model of tho EEG
response to pantothal. Perhaps Stan Yoldatain has sent
the preliminary draft to you - if not, I an anclooing a
copy.

I an ploaaod to join your society.
I cannot attend the first matting but hava asked Dr. Stanldy
Foldatoin, Ph.D. to do so.

If you believe tho enclosed report
praaaot the material in 10-15 ainutoa.
Thanks, again. for the

is of intaraat,

invitation.
Siocarely yours,
NIX

F1“,

£101).

Professor of Psychiatry

Mr:kp

cc: Dr. S. Faldatain

ha can

�</text>
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                    <text>..-.

r
”w.

..

.v—qurww,

August 23, 1969
Dr. Allen Berger
Chas. Pfizat &amp; Co.

-

Groton. Connecticut

Ref: 0? 14»368

Dear Allen,
We

have completed an

initial act

in volunteers, in single eral dosages of
was in a single trial.

50

to

of

trials

of

350 mg. Thu

CP—14,368

latter

dose

To daca, nu have failed to obscrvn behavioral or EEG effects
during tha initial 2 hour obnctvation period; and the subjects reported
no behavioral consequences for the ensuing 12 to-ZO hours.

continue theta trials, we wish to ameﬁd the protocol
earlier, to allow trials (single, oral) to 500 as.
T6

submitted

Pleaae verify.
Sincerely yours,

Max

Fink, M.D.

Professor of Paychiatry
mf/

�</text>
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                    <text>August 22, 1969
Dr.

Jhstns J. van

Gounod

Dspsrtsont of Psdistrios
University Hospitsl
Laidsn, Tbs thhsrlsnds
Dos: Dr. vsn Gounod:

Enclosed or. soap reprints describing our work. Thsss
should provide tho basis for sun. oollstorsl rssding.

I would-ho pleased to hsva Dr. Hbchslse visit my laboratorﬁns,
call (212) 369-7900. arrange-onto will bo node.
The subject that interests you is under sctivo study in
s few laborstoriss. Mhy I suggsst you read the reports of
and 1! ho V111

.

"ﬁn"

mw

Peter Kallsway of Houston;
of Chicago; and

G. Lorry

G. Psnpigliono of London; John
of Paris - to nsnn a few.

sincsrsly yours,

uw-ku—vw

Truvv

as: Pink, 3.0.

Professor of Psychiatry

warrmW

ungw,

MFskp

...~

,V

A

Inc. l128,117,101c,90

Hughso

�</text>
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                    <text>Angel: 22, 1969
Dr. George Gardoe
The Barton Mental Health Center
555 Horton Street
Beaten. Haaeaehueetta 0212A
Dear Dr. Gardoe:
we did eeaaure the EEG changes with thiothixane in 1966,
and found that, in chronic achiaophrenica, in doaagee to 30 nglday.
EEG ohangea of increaaed theta dacreaaed beta and decreased alpha

were frequent. The ehangea were not ueaaured quantitatively, for
did not do a controlled atudy of thiothixena.

we

Recently,

we have begun a

quantitative etudy of thiothixene
in volunttere
thie ie in progreaa. The EEG changes are aieilar
to theee in patienta.
and

"state of
the art" today. If you viah to vieit my laboratory, I would be
pleaaed to diacuaa your project in the light of our experience.
Encloeed are aoaa anaeary reports outlining the

Sincerely youra,
Fink. H.D.
Profeaeor of Peyehiatry

Max

Hizkp

�</text>
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                    <text>August 22, 1969
Dr. Enoch Callaway

Chief of Research
The Langley Porter Neuropaychiatric

401 Parnassus Avenue
San Francisco, California 94122

Institute

Dear Roch,

For some months, Dr. Jan Volevka, fornerly of the
Paychiatric Research Institute of Prague, has been.working
in my laboratory. He is anxious to visit some centers en
route to San Diego, and I have encouraged him to see your

laboratory.

trained, enthusiastic worker, with a keen
interest in quantification and clinical correlations. I
believe you will enjoy meeting him, and would be grateful
He

is

if a visit

a well

could be arranged.

He

I look forward to seeing

you

on September 10 or 11.

My

will call your laboratory
in

San Diego and

New

best.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Hrzkp

York.

�</text>
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              <elementText elementTextId="39212">
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                    <text>Aunt-t 21, 1969
Dr. E. N. Oawald

Royal Edinburgh Hospital
Homing-Ma Park
Edinburgh 10, Scotland

but Dr.

Oswald:

m attached invitation was nut to a nuabar of paychiatriata
in July. 1):. Shaun, a what of my ataﬂ' visited your laboratoriaa
during hia holldaya and mutant! that you might be intaraatad in
attanding a

gating

of

this kind.

In tha want that you will ha in law York follwing tha
EEG matings, I will ba planed to valcoua you.

Intamtional

Sinatraly your: .

rink, 11.9.
Profane: of Payehiatry

Max

lump

_

�</text>
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                <text>Correspondence to: Oswald, E.N.</text>
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              <elementText elementTextId="39222">
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="105759">
                    <text>August 20, 1969

Dr. Fritz A. Preyhsn
'

St. Vincent's Hospital
St.

153 What 11th

New

York, new York 10011

Dssr

Fritz,

IBM order shoots for the NYMC and tho
1800
computers. The differences in
St. Vincsnt Hospital
be
and
in memory may
significant for programming, and
speed
rocounondstion
that programming changes
for
our
for: the basis

Enclosed

will take

some

srs the

effort.

sincerely yours,
Pink, M.D.
Professor of Psychiatry

Mix

erkp

�</text>
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1
w”

m

whvﬂfuJJ'

August 15, 1969
Mr. P. Bergmans,

President
Eleevier Publishing Company
Jan van Galenstrant 335

P. O. Box 211

Amsterdam, The Netherlands
Dear Mr. Bergmana:

letter of August 5, has clarified the subscriptions to
Journal very well. The addresses are correct. I wish to
thank you for your cooperation.

the

Your

EEG

sincerely yours,
Fink, M.D.
Professor of Paychietry
Max

�</text>
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9.0“...” ,euu‘ :1 up

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:3

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7.3

7

August 15. 1969
Dr. Gaston Costellonoo
Institute National do Hourolozia
Insurgentea Sur No. 3877

Enrico 22, D.F.

Dear Dr. Costellanos:
some mail with your letter. I rocoivnd the kind
of
invitation Dr. Valance-Suarez to participate in the symposium
in Decedbor.

In the

I thank

you

participating in,
A

copy of my

for your

recommendation and
what appears to be, a most

letter

to Dr. volaoco~8unroz

I look forward to

interesting progrrn.

is enclosed.

Ilt would

be most oxciting to prepare a symposium on
ond psychiatry outing the Vth world Congress in 1971.

I look

forward to hearing from Dr. do

la Fuente and will

work with you in preparing an fino a program as

for

19710

we can manage

Sincerely yours,
Fink. 14.13.
Professor of Psychiatry

Max

Hrzkp

EEG

�</text>
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                    <text>Wm

~241¥|m¢V~n .w

'Wmivpni.1. n

.

-»--.»;

~

rum.» gum—w»-

r.r),v (”yam-r- .

,

.n.»

.-.,.-. .«.~,.ym.. 4,77,“

_.,.,.mwnr,mwr

ng

.../

.

‘

August 15 . 1969
Dr. Daniel P. Bobon
University of Liege
Clinique Psychiatrique
Rue Saint-Laurent, 58
Liege. Belgium
Dear Dr. Bobon:

I am writing in reply to your letter of July 16 and I am
pleased to have you spend a month in our Department in the spring
of 1970. It has been my experience that observers who wish to
understand our methods find them confusing until they accept the
responsibility for a specific study and attempt to carry out the
steps necessary' to write a protocol, collect and analyse the data
and write a summary. Some visitors have joined my Department for
a few days and this has given them sufficient opportunity to take
back with them an overview of our methods and facilities and attitudes.
While I would welcome you for a month, I must caution you that
this time is long as an observer and much too short as a participant.

of

Unfortunately,

we do

not have funds available for the support
on an annual basis. In the event that

visiting scientists except

you are interested in coming for a year,
on your behalf to a number of agencies.

I

visit,

I can nuke an application

to consider an application for e year’s
as thia‘will be the best for your program.

would urge you

For funds for a shorter period may I suggest you apply to
or WHO. Scientists have been sent from Europe to laboratories,
including my own, by WHO. Applications are made by the European
scientist and the roquiresent for us is to welcome them.

UNESCO

My

best regards.
Sincerely yours.
’4‘! Fink.

MOD.

Professor of Psychiatry

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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="97811">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
