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                    <text>g—Mv-"ﬂm

May

a,

1968

Dr. Fletcher Owens
A. H. Robins Company
11407 Cunmings Drive
Ridmcmd, Virginia

Dear Dr. Owens:
Enclosed is a copy of the report which we recently
read both in Tanagona and in Atlantic City. I believe
it will be published in the Proceedings of the CINP.

Sincemly yours ,
Max

Pink,

M.D.

meessor of Psychiatry

HP:kp

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                    <text>Vm‘m.wvmr

W imam-qty“ .u .w”
1‘

..

_T...,.v.,..‘...m.n.,‘,—»,

,‘Tmr.

-.

u-

t,_..

47...",

._\

.,

k

.w

v.7 .1,

.

w. ,,.

_

_

&gt;

-.

.0

"n.

-.

Irv&lt;=lm

,,
mun—w

w,

v
-

___.~..—,...—w-

May

a,

1968

Dr. David N. Greubcr't
3 Sl'xelter Rook Road
Manhasset, Long Island 11030
Dear Dr. Gmubert:

It was a pleasure talking to you on Sunday. I an pleased
to enclose a tearsheet of an article on fluphenaaim that my
associates and I have recently published, as well as a copy of
the swam-11y of the proceedings of a recent meeting held at
Sitges , Spain. In addition, copies of articles by Blachly
and Kurland are enclosed.

Fluphenazine enanthate is available as a oonmemial
5 cc ampules of 25 mg/cc.

preparation in

I

study.

am

also enclosing a

copy

of the protocol of our ongoing

In the event you would like to undertake such a study, I
to assist you and will contact the representative

would be glad

of Squibb.
My

best mgaxds.
Sincerely yours ,
Max Firﬂt, M.D.

Professor of Psychiatry

MP:kp

cc: Er. Marital

�</text>
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                    <text>'

a.”

w
v.

._~.--’~

-..-....-....

‘

.‘V

May

Henry

M.

a,

1968

Stretton, Inc.

381 Park Avenue South

New

York,

New

York 10016

Gentlemen:

I would like to have two copies of the recent
issue of Comprehensive Psychiatry devoted to computers
in psychiatry. I understand there is a charge. Please

bill

us.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

,7

Avatar".

'
tuna-tr

.1.,

,v

.
-

"wan-‘-

&gt;mww

-.

.i

an"

:uwewwgrx

:4

MF:kp

�</text>
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                    <text>.~_,,,

Hay

8, 1968

Paul de.ﬁaen, Inc.

ll

New

West

Nan Street

York,

New

York 10036

Dear Mr. de Haen:

I am interested in the "Drugs in Use" service
and possibly the "Drugs and Research". I would be
grateful for a quotation.
You may recall that we discussed this at the
recent meeting in Atlantic City of the American

College of Clinical Pharmacology and Chemotherapy.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max
MF3kp

�</text>
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«.

.1

,mvyu

nr'r‘p'twvw

-v~mwm',wv"~

'A-WE'W'A‘tw-w-

"I
V"

my 9,

1968

Dr. Richard A. Lindsay

Division of the Social Sciomu
State Urdvamity

West Texas

Cmyon, Texas 79016

mm Lunacy:

Ymmletmaddresudmminﬂissom‘imjustbem
moivodinNewak. Immmycmago. Ina
taldngtlnlibu'tyofmdingywletwmm.mxwkiner,
Associate Noam of Psychiatry at the Univmity of Miami

Sdmlofhdicimuﬂlmostymoontaothimformylulp

thatmyasaociatescmgiveyou.

Intlncvmtmiswtof

tamymmywiahmmachw. .H.C.Ho1dmatthem
instim‘tim.

‘

airmen yours ,
Max

Pink,

M.D.

Hofessor of Psychiatry

MP:kp

cc: Dr.

A11 Knsldner

Miami Institute of Paydﬁatry
51:00 Mam]. St.
St. Innis, Miami 63139

�</text>
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                    <text>my 9,

Ir.

Richard A.

1968

May

Division of the Social Sciences

West Texas State Unimity
Canyon, Texas 79016

Dear 1r. Lunacy:

Ymmletteraddreeudmminmmimmstbem

mivadinNawYmk. Imovodm‘twoyeareago. Ian
tﬂdngﬂulibwtyofwxdﬁugyamlemmm.mmm,
Associate Professor of Psydxiatry at the University of Miami

SdnolofMadicinearinWymomtmthimformyhelp

trutmyasaociatoaemgivoyou.

Inﬁnevmtmisoutof

tomyoumnywiahtomachm.J.M.C.}bldenatt}nm
institutim.

Sincerely yours ,
Pink, M.D.
Professor of Psydziatry

Max

MF:kp

cc: Dr. Ali Keakiner

Institute of
Mami
SHOO
Arsenal St.

St. Innis,

Wm

mam 63139

�</text>
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                    <text>May

9, 1968

Dr. Perry Black
2006 South Road
Baltimore, Maryland 21205
Dear Dr. Black:

Enclosed are corrected pages for the manuscript
"Drugs, EEG and Behavior" following your suggestions

0:

‘mrr-wu—

—-

yesterday.

free Levin for the whole
volume, although if reprints are to be made available
if the publisher
to the authors, I would be grateful such
use, set up my
would, as partial compensation for
reprints with this paragraph as a frontispiece.
Table II should be corrected so that the heading
You may

use the quotation

for:

.

Ia

Mai

nly increased s].oving
Alpha
Seizure Activity

Increased
It With
Ic With Increased
IIa With Increased
IIb With Decreased

Amplitude
Amplitude

in each column should be listed alphabetically,
but the parentheses should be maintained wherever indicated.
of
Also, in Table II the type selected for the title
be
should
class IV and V, alpha increase, alpha decrease,
and
Page
7,
III.
for class I, II
the same as the typeface
h marked in italic are to be rpplaced by
3
and
paragraphs
the paragraphs appended.
On page 8, a footnote should be added with the asterisk
after the word "phantastica". The footnote is appended.
EEG Applications” should
The title on page 8, "Clinical
The drugs

—

be

deleted.

page 9, the two paragraphs relating to the
should be replaced by the paragraphs appended.
On

deliriants

�-2-

Dr. Black

references
as follows:
The

May

on page 2 and 3 can be

at 3;. Digital
Psychophernacology.

9, 1968

brought up-to-dete

Analyses in
In Kline, ﬂ. and Leeks E.
(Eds) Congntere and Electronic Devices in Pezchietrz,

Fink

Grune and

Computer

Stretton, H.Y., p.

EEG

109—123, 19

.

Itil, T. and Fink, M. EEG and Behavioral Aspects
of the Interaction of Anticholinergic Hallucinogen:
with Centrally Active Compounds. In Bradley, P.
and Fink, M. (Ede), Antioholiner ic Dru e, Eleevier,
Amsterdam, p. 1&amp;9-163, 1937.
The citations should be changed on page 8 from Fink 35 e1.
(in press [a]) to Fink 33 e1., 1968. The reference to the
other citation was changed in the section on deliriente.
Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>;

E

Mira-7' ‘

5/

4

W
T0:

Dr. A. h. Freedman

FROM:

Dr.

M.

Fink

DATE:
SUBJECT:

May

l0. l968

Application of Dr. Dinnerstein
for research program on marijuana.

The theoretical problem posed by Dr. Dinnerstein is a
relevant and important one. especially the desire to measure
the effects of marijuana on automobile driving behavior.
This has public health implications as well as some theoretical

value.

The

large -

Drug

slightly

choice of subjects is good but the number seems unusually

250

trials is

a very

large sample.

administration is clear and perhaps might be modified

by drug experience.

test battery is

adequate to the theory. The number of
which these are going to be administered
is probably too large. but I assume Dr. Dinnerstein plans to run
some trials first and then select the most interesting test models.

tests

The

and the time

at

Criticisms: Perhaps the biggest criticism is the comparison
with ethanol for this puts the study on the basis that the ethanol
group was selected for some logical reason. This is not clear in
the text and I do not think the two drugs are either opposed to
each other or are necessarily similar to each other or that the
findings in a comparison bear any necessary relationships to each
other. Because of this comparison group, the number of subjects
.

becomes so
The

large.

section of significance of research leads

that the selection of ethanol or

me

to feel

even the study of cannabis
arises not from the public health interest. but from the popular
enthusiasm for cannabis. I would have thought that a study of
motor performance under cannabis on acute and chronic administration
of cannabis would contribute to our understanding of its physiology
in a shorter time than the proposed study design.
Dr. Dinnerstein does not make clear that he is aware of
the difficulties of obtaining permits to carry out marijuana
research.

�Dr. Freedman

~2-

May

10, l968

It is probable that our own acute and
- Behavioral studies could be significantly amplified
by psychomotor studies such as outlined by Dr. Dinnerstein and
a collaborative study might be considered if the goals were
simply stated.
Recommendation:

chronic

EEG

,

_

Considering the present funding policy of NIH, I think

this application is too large to

be reasonably supported and
the Research Committee might be warranted in recommending a
less anbitious program as an initial experience with marijuana

for this investigator.
MF:kp

�</text>
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                    <text>May

10, 1968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

draft

is a
I have

copy of the summary of the Sitges
Symposium.
prepared this as a summary for my staff,
but
may be useful if you plan to prepare a volume of the

Enclosed

it

Proceedings.

that

you do prepare a volume, we would
like to summarize our observations in New York more adequately
than are represented in this summary.

In the event

As I

indicated

Dr. David Graubert

on

the phone. one of

my

is anxious to undertake

a

former associates,

clinical trial

of depot fluphenazine and if such a study could be structured,
we would be pleased to process the data in our center or assist
in any other way.
Thank you once again
the symposium very much.

for your kind remarks.
My best regards.

I

enjoyed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Hey 10. 1968

Dr. E. Ned Schultz
Director, Medical Affairs
E. R. Squibb &amp; Sons. Inc.
460 Park Avenue
New York. New York 10022
Dear Dr. Schultz:
On my

enclosed

return

summary

would be useful

from the Sitges conference I prepared the

for presentation to
to you.

my

staff.

Perhaps

it

take this Opportunity to thank you for your kindness
during the meeting and your recent consideration.
Hey I

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszp

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                    <text>..
,-.

.

“Er—v

mm».

w

May

’ru
-rrr

1
raw

your

;»~:

.5,,

l0.

1968

Dr. Robert Summit
St. Paul-Ramsey Hospital
St. Paul. Minnesota SSlOl

V'er

s:
vr-v

,rrwa'm—H'u

w

mnww

ﬁv—rmwwm/mw

W:

vmm-

Wu:

W:

Dear Dr. Gumnit:

Enclosed is an abstract for your consideration for the
forthcoming meeting of the American EEG Society.
I

trust this is acceptable to

Thank you

for your consideration.

you and your Committee.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>May

10. 1968

Dr. Michael C. Barry
Medical Department

white Laboratories. Inc.

Ksnilworth.

New

Jersey 07033

Dear Dr. Barry:

Enclosed

is

a proposed Statement of

Investigator

Form (FD l572) for the high dose fluphenazine study.
In addition. I am enclosing copies of the report presented
at the CINP and a summary of the proceedings of another

related confsrencc in Sitges, Spain.

Please edit these and the proposed project to your
satisfaction. I look forward to hearing from yen.
Sincerely yours.
Fink. NJ).
Professor of Psychiatry

Max

HF:kp

cc: Dr.

Itil

�</text>
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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

�</text>
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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

�</text>
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May

Dr. Barnard C. Giueck,

Director of Research

22. 1968

Jr.

Institute for Living

Hartford. Connecticut
Dear Bax.
My

associates

and I look forward to

visiting your facilities

Shapiro. the director of our Biomadicai
Information Processing center viii Join me. as wiii three of our
proqrammers and one of my associate psychiatrists.

on Monday. June 3.

Don

In addition to the centrai processing

terminais in the clinicai units.
to visit with Dr. Stroebei.
Thank your

I would

for your assistance.

facility

iika to

My

and the
have an opportunity

best regards.
.iSincareiy yours.

Hal Fink.
MF/

3.0.

�</text>
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                    <text>23. 1968

May

Prof. Jean Babe»
Ciiniqua Psychiatrique
Liege. 8eigiqua

'

Bear Professor Baton.

It

kind-of you to consider

was

my

participatian in the

fbrthcoming ”Interdisciplinary ﬂeet on "unrelentics” in May, 1969.
i mania be pleased ta participatn. and 109k farumrd to doing so,

subject to the vicissitudes of the prnsent restrictions

on the

use of our funds for internationli travel. as yam may have hanrd,
since March 11. 1968 we have not been permitted to use any of the
usual fund: for such tnivoi, tad wt viii have tn try to obtain
new funds from other than our ntuai sources. As this it a new
situatien far us, I an unabio ta be optimistic at the present time.

interests

I did enjoy meeting your
and by

bit futility

in

tan,

who impressed an by

war ianguage.

Ha

his

would be giensed

consider an appiicatien from him to continue his studies in our
iaborateries which are deveted primarily to studies of the effects
of psychoactive drugs on the human EEE.
Again.

my

thanks for your kind

to

invitation.
Sincereiy years.

Fink. M.D.
Professor of Psychiatry

Max

”Fl

I

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102503">
                    <text>ﬂay 23. 1968

Pref. Dan H. Espiin
University of Utah
Salt Lake City
Dear Dr. ESpiin,
Your

recent report.

"A

Techniques Used to Study Drugs”

Critical Appraisal of Eiectrophysioiogicai

at the hiami

Beach symposium is
I
unabie to attend that
was
Regretfuiiy,
meeting and I am writing to ask if a prepriat may be avaiiahie.
For the past decade I have been specialiy interested in the
induced £56 changes in man by the variety of psychoactive drugs,
and have focussed on digital computer analytic methods, notabiy
period analysis. I look forward to reading your views on this

of special interest t0

me.

important problem.
Many

thanks.
Sincereiy yours,

Fink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>May

24, l968

Friedrich Hoffmeister
Katernbergerstrasse 262
Huppertal-Elberfeld
Dr.

Germany
‘

Dear Dr. Hoffmeister:

.

_,

,.,‘.

.,...w

w.“

.‘a‘wuqu

It

pleasure to hear your report at the CINP and to
discuss the problem of narcotic antagonists with you. As I
indicated, we are particularly interested in the use of antagonists
in the treatment of opiate dependence. Two reports of our work
have already appeared. and a third is in press. I am enclosing
preprints of each of these.
was a

aspects have been of special interest: the potential

Two

use of cyclazocine as an antidepressant, and the expense and
short duration of action of naloxone.

With regard to cyclazocine as an antidepressant. we were
stimulated to these trials by the similarity of the EEG patterns
of acute and chronic cyclazocine to that of imipramine. In two
clinical trials. we are impressed that cyclazocine is indeed an
and the preliminary reports of that work are
antidepzessant
enc ose
.

But it is the antinarcotic activity of naloxone that holds
the most promise. Because of its short duration of action. not
exceeding 4 hours in our trials, it may not be useful in clinical
treatment. We are encouraged. however, that other antagonists
similar to naloxone may be available in the chemists laboratories compounds with similar potent antinarcotic activity but of longer
duration - hopefully with as long a duration of action as the
long—acting depot fluphenazine enanthate or decanoate. We are
interested in hearing from you whether Bayer has such a compound

available. and if so. whether it is available for clinical trials.
there other laboratories that may have a long-acting narcotic

Are

antagonist?

�Dr. Hoffmeister

I should

-2-

May

also like to take this Opportunity to invite

24, 1968

you to
next you visit the Uiited States.
I would like to review our programs and to arrange for you to meet
the Chairman of the Department of Psychiatry, Dr. Alfred M. Freedman.
who has stimulated these studies.

visit

our

clinical facilities

Thank you

when

for your assistance.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp
ENC .

�</text>
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                    <text>'"I
v-'
»

x’ymwwl-ﬁ'ﬁf"

May
wmwwwﬂ

cw.

_«

:jlm

w-UW;

W;

27, l968

Dr. Leo Alexander
433 Marlborough Street
Boston l5, Massachusetts
Dear Leo.

Enclosed is an abstract of a presentation for the session
the forthcoming October meeting of the
C.I.N.S. in Milan. As you know, this subject, the relation of
EEG changes to behavior with psychoactive
drugs, has been of
great interest to me and my colleagues since l954. The recent
symposia at the Society of Biological Psychiatry (1965) and the
on psychopharmacology at

"m!

'cwm

:
aw

(l966) on the dissociation problem laid the groundwork for
these theoretical summaries.

CINP

Thank you

for your consideration.

r

Sincerely yours,

Amt-arm“,

K

Fink, M.D.
Professor of Psychiatry

Max

Mszp

cc:

Prof. C. L. Cazzullo
Prof. T. Ban

�</text>
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                    <text>May

28, l968

Dr. Paul de Haen, Inc.

ll

New

Nest 42nd Street
York, New York l0036

Dear Dr. de Haen:

Enclosed are the terms that I believe would
cover the range of psychoactive drugs of interest
to psychopharmacologists. I would like to ask you
for an estimate of the cost for a subscription to
the 'de Haen Drugs in Use" from the beginning of
your collection to date and an annual subscription
rate for the compounds in these classifications.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

A

“Song”

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                    <text>wv-r-n

awn

May

29, 1968

Dr. Ali Keskiner
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear

Ali,

He have just received the reprints of the long acting
phenothiezine report. Separately, Kathy is sending you a
large supply of reprints and tear sheets. He will answer
some of the re rint requests here. but if they get to be
too many we wi l send them on to you. Please fill those
that come directly to you. since we are keeping a small supply
of reprints.

“Ii-w

imam-v:—

vrpv'i‘lv’w'z'vl'ﬂvx

.v

'(F‘WW‘Q‘K'

y7;

www-‘WW

"tjl'rﬂjr

ay-

-r--

.1»

Tepkapi
My

is doing will as

you

will hear separately.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>May

Dr. Paul Blachly

University of Oregon Medical School
Department of Psychiatry
3181 S.N. Sam Jackson Park Road
Portland. Oregon 97201

’

Dear Paul,
Thank you for your letter of May 22. I would be pleased
to participate in the Institute, especially since Dr. Jaffe
will also be present. The idea of such an institute is new
to me and I probably will plan to be there on August 14 and 15.
I will plan to discuss the psychopharmacological treatment
of opiate addiction, emphasizing some of the newer experimental

approaches.
Your

run our

visit

encouraged us very much and I am planning to
ECT during the forthcoming week.

first monitored

Thank you

for your kind invitation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

’

"
~‘

.“"
‘

:‘ﬁw'vweanﬂhmw

kifﬁﬂW.-/

_

,W

ran?

29, 1968

�</text>
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                    <text>January 2, l968
Dr. Hilliam Karliner

Franklin Road
Scarsdale, New York
20

Dear

Bill,

Miss Harriet hernstein had a repeat electroencephalogram
on December 28. The record indicates that she received dilantin,
390 mg/day and Tofranil. 150 mg/day. She appears less depressed
and is in good contact. Emotional lability is no longermmanifest.
The electroencephalogram was repeated (#406). The rhythms
were symmetric with the same amount of alpha and beta activity
as previously. The amount of theta activity was increased and

the beta activity

was more prominent

in all leads.

0n hyperventilation, high voltage spike and wave
activity
appeared for let seconds after 180 seconds and after llO seconds.
There was no additional seizure type activity in the record.

There is no evidence of increased seizure

result of imipramine.

would suggest

it

activity as a
status,

In view of her improved mental

that she continue

on imipramine.

In the event that you plan to discontinue her medications

may

be useful

to repeat the

dose of imipramine.

EEG 7 ~

l0 days after her last

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

I

�</text>
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                  <elementText elementTextId="102496">
                    <text>‘w-"C‘LWJ‘.

Karly—71"!”

,

.77.

Harem-www-

January 8, l968

raw,m&lt;~A-w~‘-‘v'

.

0r. Jerome Levine. Chief,
Barlow Building

PR8

5454 Wisconsin Avenue
Room lGCOl

Chevy Chase, Maryland

Dear Dr. Levine:

RE:

I am writing with regard to rebudgeting
(EEG and Human Psychopharmacology).

MH-l3358‘0l our

account 4l-382-l

MH-l3358-0l and ~02

In reviewing the expenditures for 1967 there are $5500 in
unexpended funds which may be carried over into l968. A revised
25-90~l (Section III) is enclosed. THIS XS UhAUDITED AND COMES
FROM MY RECORDS ONLY.

This sum should be used to reduce the award of Mh-lBSSB-OZ.
We

be aware

also reviewed the request budget for l968. You may
that HH-l3003—02. a grant to complete studies at the

have

University of Missouri runs concurrently from 9/1/67 through
8/l/68. Except for some consultation and travel items, it has
not been necessary to utilize this budget and $9,000 remains.
This will be used during the first few months of l968 and it is
suggested that MH«l3358~02 be reduced in this amount.

revised request budget for the ~02 year is attached. The
sums carried forward and the balance of MH-l3003 will be used to
reduce the personnel item.
A

These modifications in the l968 budget meet with the approval
of the executive administrator of the Department of Psychiatry and
the Vice President. both of whose signatures appear below.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max
APPROVED:

B. §chwartz
l.Executive
Administrator

Department of Psychiatry

“FL Haydn Morgan. Vice

President

Research Administration

�</text>
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                    <text>January 8, 1968
Mr. w. H. Bold

Manager, Clinical Research Associates
Squibb Institute for Medical Research
New Brunswick, New Jersey 08903
Dear Mr. Bold:
an

The Prolixin study is going well. He do, however. need
additional supply. of oral Proloxin. l mg. would you

kindly send us

4

bottles.

500

Thank you very much and

tablets each?

my

best wishes for the

New

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Year.

�</text>
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                  <elementText elementTextId="102494">
                    <text>January 8, l968

Arthur J. Lunny
Chart Paper Sales
Grass Instrument Company

Mr.

Quincy, Massachusetts 02169
Dear Mr. Lunny:
boxes

On

our outstanding oeder of

to

my new

laboratory.

EEG

paper. please ship

25

Dr. Max Fink

Department of Psychiatry

Metropolitan Hospital,

First

ﬂew

Separately

December 29,

we

Avenue

at

Room l5A9

97th St.

York, New York 10028

are sending you an additional order, dated
100 boxes. Please bill us promptly.

for another

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                  <elementText elementTextId="102493">
                    <text>January 10, 1963
Dr. Daniel Siiverman
269 South 19th Street

Philadeiphia 3. Pennsylvania

Dear Dan,

Enclosed

American

EEG

discussion.

is a final copy of the presentation at the
Society. as well as modifications of the
I

trust this is satisfactory.

for your patience.

Many

thanks

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Mex

NF:kp

�</text>
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          <element elementId="50">
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              <elementText elementTextId="32604">
                <text>Correspondence to: Silverman, Daniel</text>
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                    <text>January 10. 1968
Dr. Heinz E. Lehmunn

Clinical Director

Douglas Hospital
6875 Lasalle Blvd.
Verdun, Quebec
Canada
Dear Heinz.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
New York MedicallCollege on May 3l.
The seminars are held
at the Metropolitan Hospital (97th Street and First Avenue)
in the conference room on the 15th floor at 11:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss “Psychological Tests
and Drug Effects.“
We

I

will defray your expenses and there will be an honorarium.
will call you before Hey 3l. Thank you for accepting

our invitation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 10. l968
Dr. Nathan 5. Kline
Recklend State Hospital
Orangeburg, New York

Dear Note.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
New York Medical College on June l4. The seminars are held
at the Metropolitan Heepital (97th Street and First Avenue)
in the conference room on the l5th floor at ll:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss “Psychopharmecology

Research in Private Practice."
We

I

will defray your expenses and there will be an honorarium.
will call you before June 14. Thank you for accepting

our invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>32‘.

V-w

Mr

was
'u.

January

l0, l968

Dr. Charles Shagass
Temple University

Department of Psychiatry
Philadelphia. Pennsylvania

Dear Charles.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
ﬂew York Medical College on April 5. The seminars are held at
the Metropolitan HOSpital (97th and First Avenue) in the
conference room on the 15th floor at ll:00 a.m.

s-‘wrrwx-wws

;~

I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss "Drug Response in

Classification.“
we

our

I

will defray your expenses and there will be an honorarium.
will call you before April 5. Thank you for accepting

invitation.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>‘M’u":

u

January l0. l968

wrw.

Irv“

Dr. Jonathan 0. Cole

Boston State Hospital
Boston. Massachusetts
Deer Jonathan,

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmecology at the
New York Medical College on March l5. The seminars are held
at the Metropolitan Hospital (97th Street and First Avenue)
in the conference room on the l5th floor. at ll:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss the clinical antidepressants.
he

our

I

will defray your expenses and there will be an honorarium.
will call you before March l5. Thank you for accepting

invitation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>January

l0. l968

Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39

Dear Taran.
Enclosed is the galley protf and the letters on the
fluphenazine paper. I have made all the corrections that
they have requested and would ask only that you please check
Table I. I think that “years“ under the average number of
hospitalizations is unnecessary.
I am ordering 1,000

for everybody.

If you

directly to

reprints,

which should be enough

have any additional changes. please send them
Miss Slotky with a copy to me. My best regards.

Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

Mfzkp

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                    <text>v

January 10. l968
Miss Karon Slotky
Copy

Editing

ﬂepartment
American Monica Association
535 horth Deartorn Street
Chicago. Illinois 60610

war

~wwm..wr:wrmwm-

Dear Kiss Slotky:
I am returning the text of our report ”Longuncting Depot
Phenothiazina Treatment of Psychosis,“ which is to appear in
the forthcoming issue of the Aachivea og Gaaaaat Raychzatag.

rsmuv'u

Please change the

0:"

Wm.”-

The

«v.3,-

.A-

name

of the coauthor to Turan

M.

Itil.

M.o.

address listed is a permanent address.

V.

wm.

With regard to the reference now numbered l6, this appears
The original text is incorrect and reference l5
ei
page be 2t.
0:
s.ou
.

l967

l 0.

The personal communication

of reference

There are minor corrections in the
In Table

text

11 was

oral, July 22,

on pages 1, 2. 9 and

”yaars" for average number of
ambiguous. That should be deleted.

I, tho subscript

hospitalizations is

In other regards the

text appears correct.

Finally. I believe the layout can be improved. The layout
shows the report beginning on the left side of the page. This
is awkward and if at all possible. perhaps this report should
two of the results and the
start on the right side. Paragraph
4
do
go together. If we start on
figure which now is on page
a right~hand page than the first paragraphs of the rasults
will appear on a page facing the figure. I would also suggest
a realignment of those pages so that tho figure and the legend

�Miss Slotky

«2-

January 10, l968

appear on the upper left~nand side. in the location on page 3
where Table 1!! now appears. By continuing the copy so that
extends on the loner half of the left column and the upper

it

half of the right column. Table
of the right column of page 3.

111 can occupy

the lower half

For page 4. Table IV might suitably occupy the upper righthand part of the page so that the text fills in the left side
and all of the left column. The comment would then appear under
Table IV and would continue to page 5. It would not be necessary
to change page 5.

if

the recommendations for page

The

reprint order is enclosed

are unsatisfactory an:
in the lower half of page 4
filling out the right-hand corner, allowing the copy to complete
the left side and the upper right part of the page.

alternate approach is to

h

,

“am“.

,.,‘.

.—

_-;&lt;«

.n
.urv

_

-,
:-

will follow.

4

have Table IV

and a formal purchase order

r,

Thank you very much

“urea-wry;

for your assistance.
Sincerely yours .
Fink, ".0.
Professor of Psychiatry

Max

MF:kp

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                    <text>January l0, l968
Dr. Carl Salzman
ECDEU

Psychopharmacology Research Branch

National Institute of Mental Health
5454
Wisconsin

Chevy Chase, Maryland

Dear Dr. Salzman:
The members of my staff who
attended the ECDEU meetings
week were very much stimulated to
participate in this
collaborative program. I believe the meeting
was a success
and I am grateful for the extensive work
that was done in

last

preparing the forms.

As we undertake new
studies, the forms will be included
and I look forward to the analyses
as projected.

Dr. Itil shared with me the reluctance
of the participants
to use a more definitive laboratory
rating
scale.
This appears
to me to be the only form of importance that has been
omitted.
I plan to use his and we will
process this ourselves.
Thank you

for the courtesies

you extended to

my

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

staff.

�</text>
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                    <text>January

ll.

l968

Hr. Robert Shearman
IBM

2ll

Corporation

Montague

Erooklyn, haw York
Bear Bob,
I am sorry that I missed you during
your recent visit. but
had told me of the change in your assignment. I want'to
thank you for all your help in establishing our small computer
unit. It is exciting to realize that we are operational
and
in less than one year.
Don

May.

still some question about the demonstration in
but this should be resolved within the next few weeks.
There is

thanks again for your help and
continued success.
My

my

best wishes for your

Sincerely yours,
Fink. n.0,
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>1-. —..

January

ll,

«wwvv—mmrmrmmwWLWVPr—v'
,

l968

Dr. Francis Latteri, Chainnan
Pharmacy Committee

Metropolitan Hospital
97th Street and

New

First

York, New York

Dear Dr.

Avenue
‘

Latteri:

During the past few months, patients of the Mental Health
have received medication not prescribed or amounts that
were insufficient to provide for the time between visits from
the pharmacy at Metropolitan Hospital. Such events were occasional
early last year but have became increasingly frequent.

Clinic

'

staff of the Department of Psychiatry have reviewed
of the newer dosage farms of established pharmaceuticals and
would like to recommend that these be made available.
some

Also, the

May I

and would

agenda?

inquire as to the next meeting of the

it

Pharmacy Committee
be possible to have these two items placed on the

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

ﬂszp

�</text>
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                    <text>January

ll,

l968

Dr. Joseph 6. Bird

Sterling~hinthr0p Research Institute
Rensselaer, New York l2144
Deer Joe.
I

have received the supplies of cyclazocine (0.25 mg) and

placebo to match.

I think these will suffice for the remainder
of study #l. I have asked Dr. Simeon and Dr. Zaks to replace
the active medication with placebo in each of the patients and
to observe the changes which follow.
May I take this opportunity to thank you for
your thoughtfulness
in sending me such a fine holiday gift. I took this
home and my
wife and I are pleased to thank you.
My

best regards.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

�</text>
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                    <text>January
Mr.

Gilbert

M.

ll,

1968

Barcus

Mcﬂeil Laboratories Inc.
33l0 Nostrand Ave.

Brooklyn,

New

York

Dear Mr. Barons:
I regret that your failure to call my office for the opportunity
to present your questions may have led to some confusion. You must
know that a consultation in the hall is highly inappropriate.

If I understand your question, it was whether we were willing
to undertake a clinical study of haloperidol or any other procedure
which would make this drug available for clinical use.
Please be advised that for the past year the Department of
Psychiatry has had an established committee to review recommendations
for new drugs for clinical use. This committee, the Psychopharmacology
Study Group, meets at irregular intervals at the request of the Chairman
to review the available data prior to making recommendations to the
Formulary Committee of the Medical Board of Metropolitan Hospital.
If

McNeil

Laboratories is interested in having haloperidol

would suggest that you write a letter to me and submit
six copies of any information you wish to bring before the committee.
I will be pleased to have the committee review this recommendation at

reviewed,

its

I

next meeting.

~

Incidentally. the administration of compounds not accepted in
the formulary by members of the staff is governed by the
ulotions
regarding research in humans. To comply with those regulat cos it
would be necessary to submit a formal protocol to the Research
Committee of the Medical School. the Medical soard of Metropolitan
Hospital and to the Commissioner of Hospitals of the City of New York.
For this reason. I would urge you not to distribute samples of this
compound

for clinical trial as

you attempted with me.

indicated. I would be pleased to hear
your research division at any time.
As I

from members of

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr.
.,
,w

m

me'rv-

V.

Slotnick

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                    <text>January

ll,

l968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue

New

York.

New

York

Dear Alain,
I look forward to having you join us on February 2.
Enclosed is a list of the seminars in psychopharmecology
for the residents and I look forward to having you discuss
with them the practices and problems of new drug evaluations.
The presentation will take place at ll 00 am at
Metropolitan Hospital (97th Street and First Avenue) in
the fifteenth floor classroom. The group will consist
primarily of first year residents and some additional
members of the staff.

.

AV:

V

w-wvauw;7-l\-

"

'~‘r

At l2:l5 pm we plan to meet with the whole staff to
present our experiences with long acting fluphenazine.
Dr. Bucci is away, but as soon as he returns he will summarize
our data and we hope we can get it to you before the presenta~

tion.

www-

'
xv:

_my:~mtrnvmr

Incidentally. I received the corrected text from the
Anchivea 05 Genenaz Payehiatay of our report and this should
appear shortly. I have called Mr. Bold and asked him how many
reprints he would like.
I look forward

-

to your participation in our program.

best personal regards.

Sincerely yours,
Fink. h.D.
Professor of Psychiatry

Max

MF:kp

My

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                    <text>w»

.mmmw

warp.

"win!"

January

ll,

1968

Dr. William R. Tabor

A. H.

Robin: 00.. Inc.

1407 Cummings Drive

Richmond, Virginia 23220
Dear

Bill.

Enclosed is a copy of the abstract submitted to the
Society of Biological Psychiatry. Unfortunately. the abstract
was sent too late and the Program Chairman has indicated that
he is unable to include this presentation.

Nevertheless.

can and

will send

I

plan to complete this report as soon as

you a copy.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

I

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                    <text>January l5, 1968
Dr. Ralph Jacobson.

w‘»

Associate Medical Director
Endo Laboratories
1000 Stewart
Garden City. New York ll533

“

av:

v"

w

Dear Dr. Jacobson:

1.?

Lawn-m7.“

Enclosed are two copies of the prelﬁminary report "Naloxone
(N-Allylnoroxymorphone) in Opiate Dependence."

inquire as to the present status of the production
of naloxone for further clinical trials?
May I

Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max
'4".-

:I
"
'-.'r:.;,.~:;-.'-

11-;-

ﬁt?

1'.

~2'.‘~E¢r

.Q'

-'
’7:

{wa.;gu"ﬁv§.h2?§~

"

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-.'.:-i-!'-

grrrogdl

ff}
1v
'

'
‘A'w

‘75")

"-

2mw=zm¢agr

3p";

MF:kp

one .

�</text>
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                    <text>January l5, l968
Mr. Harry Henderson
World Wide Medical News

l30 East 59th Street

New

Service. Inc.

York, New York 10022

Dear Mr. Henderson:
We have recently completed a small study regarding the
treatment of nercOtic addicts using a new narcotic antegonist.
The compound is of sufficient potency to be of great clinical
interest. Unfortunately, the compound is no longer available
because of the expense of production since the patent is held
by a small pharmaceutical corporation.

If. after reading this report, it is if interest to

you,

appreciate your calling me regarding the necessary
releases from the institution prior to public description.
I would

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>January 15. 1968
Dr. Alan

Miller.

Commissioner

Department of Mental Hygiene
Albany, New York
Dear Alan.

at the ARNMD. we have recently completed
of an interesting new compound in the treatment of
narcotic addiction. A copy of the report is enclosed. I have
also sent a copy to Dr. Brill.
A: I mentioned

a study

Further studies

seem hampered by

limitations of the supply.

This compound has been produced by Endo Laboratories of Garden City,
Long

Island.

He

would. of course. like to continue these studies.

Your

cooperation in making supplies available for further study would
be appreciated.
Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

Mszp
ENC .

�</text>
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                    <text>..

”v.

.
.

.A..

aim-«ﬂyhm

K'n'ﬂ‘xI-nvw,‘

January
Dr. Henry

Brill

narcotic Control

l5, l968

Commission

l855 Broadway

New

York, New York

Dear Henry,

pleased to enclose two copies of our report ”Naloxone
(H-Allylnoroxymorphone) in Opiate Dependence.“
I am

v

.

Further studies of naloxone are necessary. As I mentioned
available.
to you, Endo Laboratories has not made supplies
have communicated
whom
we
with
0r. Ralph Jacobson is the physician
with regard to this problem.
Sincerely yours,

«Iv

.A

Fink. M.D.
Professor of Psychiatry

Max

mmvwemnw—

‘w

MF:kp

�</text>
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V,

$1er

ww‘wm

January 16, 1968

are:

:1:
,

9-4187”

.x-W:mggi

Dr. Richard Ellingson
Nebraska Psychiatric Institute

602 S. 44 Avenue
Omaha, Nebraska 68105

m?v&lt;m.w:mn

Dear Dr. Ellingson:

It

was a

My

best regards.

pleasure to participate in the Sugerman project
I am taking the liberty of enclosing copies
of reports recently prepared which summarize our present view
of the relation of EEG. psychotrOpic drugs and behavior. These
reports were prepared for the recent ACNP meetings. and are to
be considered drafts requiring additional editing.
review on Friday.

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

MF:kp

&lt;
-

,.
wt
21.1»

v
'1

Livtwrpﬁqugnwj

a'qx..ﬂExI-fgg;g

.‘ﬁ'sJS-f,‘

"1‘,
V,

�</text>
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                    <text>January l6, 1968
Dr. Sol Goldberg
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chane, Maryland

1

.A:ynn‘nw,._.-..

-w

.&lt;.wr«

.1

w
.7»;

«In

V7,,—

m

Dear Dr. Goldberg:

It was a pleasure being with you on Friday. The discussions
of the Sugerman proposal suggested that draft capies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing. but
they do describe our present view of EEG. drugs and behavior.
ﬂy

best regards.

w".

&lt;

Sincerely yours,

”

mmw-

r?!

a“

w

aural

Fink, M.D.
Professor of Psychiatry

_

Max

Hszp

�</text>
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                    <text>January l6. l968
Dr. Sol Goldberg
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chane, Maryland

Dear Dr. Goldberg:

It was a pleasure being with you on Friday. The discussions
of the Sugerman proposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing. but
they do describe our present View of EEG, drugs and behavior.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>January

l6, l968

Dr. Carl Salzman

Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase. Maryland
Dear Carl,

pleasure being with you on Friday. The discussions
of the Sugermangproposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing, but
they do describe our present view of EEG, drugs and behavior.

It

was a

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>January 16. l968
Dr. Burtrum C. Schiele

Professor of Psychiatry
Department of Psychiatry and Neurology
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dear Burt,

It

was a

My

best regards.

Friday. The discussions
of the Sugermen proposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing, but
they do describe our present view of EEG, drugs and behavior.
pleasure being with you

on

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January l6, 1968
Dr. Richard Ellingson
Nebraska Psychiatric Institute
602 S. 44

Avenue

Omaha, Nebraska 68105

Dear Dr. Ellingson:

It

was a

My

best regards.

pleasure to participate in the Sugerman project
I am taking the liberty of enclosing copies
of reports recently prepared which summarize our present View
of the relation of EEG, psychotropic drugs and behavior. These
reports were prepared for the recent ACNP meetings, and are to
be considered drafts requiring additional editing.
review on Friday.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January l7, l968
Dr. S. Clyde Strickland
Merck Sharp &amp; Dohme
West Point, Pennsylvania l9486
Dear Clyde.
have received the supply of 2400, 2 mg tablets of
Cogentin. I want to thank you and to tell you that I regret
the difficulties. we have not been able to trace the first
We

package.

Thank you very much

for your couperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>.

.

Jammy 18,

"mam-w

V:',vc"nmu'.

4""

1968

Miss Karen Slotky
Copy Editing Department

Meal

American
Associatim
535 North Dearborn Street
Chicago, Illinois 60610
WWW»7«W‘&lt;1'z‘waywavxe-ww

A

Dear Miss Slotky:

I am writing with regard to the report "Long—Acting Depot
Phenothiazim Treement of Psychosis." My associates in St. Louis
have reviewed the paper and I an enclosing pages which they feel
warrant correction.

_
«ray-W

'W

'

The page nunbers referred to are your page numbers, marked in
the upper right hand corner. On page It, the last line of paragraph
lshouldmsd’WtoQSmeks." InpamgraphZ, tmelinesfmthe
bottan delete "(Table 2)." The last sentence should
be changed by
deleting "disoonfort and secondary" and replacing by "eutrspyrmnidal."

'I‘i-‘AWUW'TW

64"

l'.

On

page 5, the paragraphs require a few changes and these are
the attached page 5.

marked on

principal changes are in the results and I have taken the
liberty of retyping pages 6 and 7. Following your editing, please
use these to substitute for all of 6 and most of page 7 up to the
portion marked secondary effects.
On page 8 , we Nomad suggest that paragraphs be deleted foam
the section starting "10 patients in group Eb" and "9 patients in
The

group 2" .

Similarly, the section on page 9 "there was no weight loss"
is logically a continuation of the previous paragraph.
_

In the smmsry, in paragraph 2, the third line should be
charged to read "discmrgeable, and seven did not improve. The”

(the

word secondary should be

deleted).

�-2-

Miss Slotky

January 18, 1968

Finally, the tables have became inverted and table 3 should
2 and table 2 shwld be marked table 3. m1: is,
2
in Individual Symptoms with Fluphenazine
"Changes
table is
Decanoate" and table 3 is "Mode and Outoane of Treatment."

be mrked table

Thank you

for your cooperation.
Sincerely yours ,
Max

Firm, M.D.

Professor of Psychiatry

MF:kp

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                    <text>«~3-

armarn

‘r‘r‘

”WW-u-

man-r

"qr-(mum

:w

W

-,.w

"Irw-o-m—wmmmmv

r

January l9, l968
Dr. Jerome Levine
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Uisconsin
Chevy Chase, Maryland
Dear

Jerry,

Enclosed are two cepies of the report "Naloxone
(N-Allylnoroxymorphone) in Opiate Dependence."
my coworkers and l are saddened by our
additional supplies of this compound.
obtain
to
inability
To us, further studies are important as the therapeutic
potential of this compound appears extremely high. we
would appreciate any efforts that you can make to obtain
the cooperation of Endo Laboratories in further production
of this compound.

As

you know,

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>January 22, 1968
Dr. John L. Voigt. Director

Pharmaceutical Extension
Rutgers - The State University
l Lincoln Avenue

Newark,

New

Jersey O7l04

Dear Dr. Voigt:
be

Thank you very much for your invitation. While I would
interested, I will be out of the country on March 2.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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Dr. Gerald L. Klerman, Director
Connecticut Mental Health Center
P. 0. Box 1842
New Haven, Connecticut 06508
The

Dear Gerry,

It was kind of you to accept my invitation to participate
in the resident training seminars in psychopharmacology of the
New York Medical College.
have requested a special meeting of the class on Tuesday,
at 4:00 p.m. The meetings are held at Metropolitan
97th
Street and First Avenue.in the fifteenth floor
Hospital.
I

March 19,

classroom.

it

would
you can see from the enclosed list of seminars,
would
in
discuss
social factors
the evaluation
helpfulif you
of treatment and in the effects of psychotropic drugs.
As

be

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>~

.A.«

.i

v

.n.

r'

-'-w--"\"

‘
-

M‘V-ﬁ/rwp'wn—W‘W'Wmm-‘vu-I—vr

January 24, l968
Dr. Turan H.

.

.uwvzns

.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Turan.
I have

received a

letter

from Dr. B. Lebedev of the World

Health Organization inquiring about our Turkish collaborative
study. A copy of his letter is enclosed as well as my reply.

1’!

wow

4.7K.

‘Vl'i.§&lt;

Would it be possible for you to visit with us on Friday,
February 2, to discuss a presentation before the Separtment
staff? Drs. Bucci and Simeon are presenting our observations
with depot fluphenazine and we would be pleased to have you
discuss this presentation. The meeting is held at l2:l5 pm
in the sixth floor auditorium at Metropolitan Hospital (97th

Street

var:

My

and

First

Avenue).

best regards.
Sincerely yours,
Fink, N.D.
Professor of Psychiatry

Max

MF:kp

_
A

.»

:ﬂwwm‘ﬁwtﬁ'ﬁlhr'y-s-

new-v»

a1"

‘1'

�</text>
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                    <text>January 24. l968
Dr. 8. A. Lebedev

medical Officer

Mental Health Unit
World Health Organization
Avenue Appia
Geneva « Switzerland

lle

Dear Dr. Lebadev:

It was

good to hear

that

you are

still

considering a

meeting of investigators interested in international studies
with psychotropic drugs. Our study programs with the

University of Istanbul are progressing well, and it is on
route to that Center that I plan to stop in Switzerland.

I am confident that Dr. Itil would be pleased to represent
this program. He is PrOQEssor of Psychiatry at the University
of Missouri School of Medicine and holds a concurrent appointment
at the University of Istanbul. His address is:
Dr. Turen

M.

Itil

Professor of Psychiatry
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri

My

63139

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>v7”.

January 25. l968
Dr. Perry Black
Division of Neurological Surgery

Johns Hopkins HoSpital
60l North Broadway
Baltimore, Maryland 2l205
Dear Dr. Black:

Enclosed are two copies of the report "Orugs, EEG and
and the
Behavior." as a contribution to the symposium "Drugs
Bra n.‘

mammm

.wn‘

w"

1:
u,

is.

For publication purposes the prooer academic affiliation
Professor of Psychiatry. New York Medical College.

31-me-

Thank you

Wm

r

for your kind invitation.

"'

1;:-

Sincerely yours,

.
~,\,/€?:Il,

1»;ngst

Fink. M.D.
Professor of Psychiatry

Max

wan-man:

&lt;WF“K:V(J!Z-!‘

QWER'm-J-mewat

‘-'
W?

‘-’-”'?'-'«""‘

:»

raw-«xv

i""ww1eermmi-1

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mmgm

IZZY-.7

Mszp
GHC.

�</text>
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                    <text>January 25, l968
Dr. Daniel Silverman
269 South l9th Street

Philadelphia 3, Pennsylvania
Dear Dan,

in no position to advise you on how to act with
delinquents. Perhaps reconstructing the remarks of recalcitrant
discussants or omitting their remarks all together are the
I am

principal solutions.

delighted if the; were to appear as a supplement
Journal. I have no objections to editorial assistance

I would be

to the

EEG

from Hoffman-LaRoche.
Good luck!

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

a

‘

WWII.”

�</text>
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                    <text>January 26. 1968
Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School

5.”.

3181

Sam

Jackson Park Road

Portland, Oregon

97201

Dear Paul.

project at Gracie Square

has begun and like all such projects
have obtained the concurrence of the staff and
appointed both a nurse and physician to the staff. I am recommending the
appointment of a psychologist whom I have Just met. The EEG equipment was
delivered this week and the laboratory will be set up early in February.
We have written some computer
programs for diagnosis using the Hamilt‘n
The

is progressing slowly.

Rating Scale.

We

expect to
bilateral treatment in
MMECT in the early summer.
and

'
.
*’

‘*2

I

make some
March and

A few days ago I received a phone call from Dr. Strain who heard
of my interest in ECT. He reminded me that he is coparticipant in our APA
panel, and while I have done little for that presentation, I look forward
to it.

I read your

notes

on

and the observations are very

'
M"

-'
’

-,.
-

12:11:.s,»‘~'=«;~

.«pr

1.0.2:»

"w

-

systematic observations in unilateral
and should be ready to start

April,

Pyridoxine.

interesting

this
further study.

I know nothing about

and warrant

compound

Enclosed is a preliminary report of our experiences with naloxone,
as well as a reprint of our cyclazocine data. Of the two drugs, used in
the same population, the naloxone gave us less complications, was better
accepted and seemed more promising as a therapeutic agent than cyclazocine.
I regretqi very much that we were unable to continue our study because the
manufacturer discontinued production because of expense. I am trying tn
every reasonable political way to urge continued production of the compound
for I think it holds much promise.

-.?r.".«':‘rW€;.-N+f.~.m.

Fem

ﬂat—ﬁle.

for

Incidentally, your

comments on acetylmethadol

are most interesting,

have never heard of this material. A year ago we asked Sterling Winthrop
(and were supported in our request by NIMH) to produce a long acting cyclazocine.
This has not yet been done.
I

My

WWW

"ﬂ

best regards.
Sincerely yours.

HT’VK-Willi-

'1713i75m7W-u72'v'ﬁ”

Fink, M.D.
Professor of Psychiatry

Max
W

FV‘T'

if"
—

5
~

MF:kp

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                    <text>January 26, 1968
Dr. 3. Clyde

Merck Sharp

West

&amp;

Strickland
Dohme

Point, Pennsylvania

19486

Dear Clyde.

In Monday's mail we received an additional 2400 tablets
of Cogentin. There was no packing slip nor any date on the
outside wrapper. so I cannot tell which of the two supplies
came

first.

Many

thanks and we

now

have more than adequate

supplies.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

l

�</text>
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                    <text>January 26, l968
Dr. Harris

Lexington. Kentucky 40506
Dear Dr.

acetylmethadol or compounds like
Many

sir—v4-

thanks!

Fink, M.D.
Professor of Psychiatry

Max
r2.

”nun

it?

Sincerely yours,

4-

w

lsbell:

In the course of our studies with addicts we, like others,
have tried methadone maintenance. In a communication from
Dr. Paul Blachly, he indicates that you have had experience
with acetylmethadol - "slow dope." Can you tell me if your
experiences have been reported? what is the availability of

7-

wy'rvvwrm-u

Isbell

Professor and Acting Chariman
University of Kentucky
College of Medicine
Department of Medicine

MF:kp

�</text>
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                    <text>January 26, 1968
Dr. Bernard Swerd10w
336 Third Avenue
Long Branch, New

Jersey 07740

Dear Dr. Swerdlow:

Enclosed are some of the rating forms which I d1str1buted
lecture last year. as weli as two in use in our c11n1c.
which may be of interest to you.
1n the

Thank you

for your inquiry.
Sincerely yours,

m.
um

72a»

A
.

Fink, M.D.
Professor of Psychiatry

Max

vary!»

;

‘»
«r

Prat:-

rat-17.

,‘YMKJﬂfhh

’;‘!-'u

r'

me‘&amp;ﬂs:w‘mmw

WW-

.z"

g

Mszp

�</text>
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                    <text>January 29, l968‘
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39
Dear Turan.
Dr. Karczmar has asked us to revise the 1966 ACNP
report.
In view of the fact that this paper reports our
original
descriptions of cyclazocine and of the subsequent importance

of this observation,

your participation.
I hope

I have changed

the authors to reflect

this meets with your approval. File copies are enclosed.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

enc.

"7"

‘
m
o

“r:

5:w-:-.~

331.?

w-V

Wraimwv

I

”I.”

,1,

�</text>
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                    <text>January 29. 1968
Dr. Joseph G. Bird

Steriing~winthrop Research Institute
Rensseiaer, New York 12144
Dear Joe.

Enclosed is a revised and updated capy of the report

of our EEG studies with cyciazocine. The originai was
presented at the ACNP meeting in 1966 and it is now going

to press.

‘

of the clinical experiences with cyciazocine
as an antidepressant is continuing and we should have a report
The review

avaiiabie very shortly.

Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max
NF: kp

enc.

�</text>
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                    <text>.
",4

m—Apﬂ',’(‘ﬁv~hrjmwrr&lt;

January 29. 1968
Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York.

New

York

Deer Alain,

Enclosed is a copy of the staff announcements for
this Friday's presentation. and a copy of Luigi’s notes.
Dr. Simeon will report on the data from Missouri, and a
copy of that report is enclosed.
As I mentioned, I would be grateful if you would join
me about quarter of eleven, l5th floor, Metropolitan Hospital
in the Mental Health Clinic (inquire at the psychiatric office).
At ll o'clock I would like you to Join me in talking to the
resident physicians about the methods ind problems in new drug
evaluation. They have had two lectures already, one on the
history of psychooharmacology and one on models and classifications
0 drugs.

Turan

is planning to Join the

can have lunch afterwards.
My

noon

lecture

and perhaps we

best regards.
Sincerely yours.

4.,

Fink, M.D.
Professor of Psychiatry

Max

_.

we!

we

Wm

.mm

MF:kp

�</text>
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                    <text>,

at“

an

—,

.r‘

.-..-,7.-.

meq-uuc—

ﬂanuary 29, 1968
Dr. A. Karcznar
Loyo1a University
Stritch Schooi of Medicine

Hines, I11inois 60141

Dear Dr. Karczmar:

Enciosed

is

of Cyciazocine.

that:

Note

A

draft of our report.

a revised

Narcotic Antagonist." and

.

"or.

#0353“

0
o

a

050'?

o

a

Patterns
additionai figures.
“EEG

Authors - revised

Credits
Pages

—

4—9

revised
- revised

Reference pg. 1.

citation

Freedman gt_gl; - updated
Figures added
Legend added

Please revise the draft in your hands according1y.
Sincere1y yours.

Fink, M.D.
Professor of Psychiatry

Mex

Mszp
GRC .

.
q.

WVMWW

'

‘

�</text>
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.7

My...”

run-wwu

'B-nU—WU—w-H‘Wkw

w»&lt;W-mrnwmvtwwlvw~ns

r

'1

-~

WW,

..-..-

-

:v-

1',u~&lt;

.

...

p -:v~ ‘IY'V" wm‘ww-r'wm"‘

"-v-

“a;

January 30. 1968
Dr. A. Karczmar
Loyo1a University

Stritch

Schoo1 of Medicine
Hines, I111nois 60141

Dear Dr. Karcimar:

P1ease rep1ace the 1egends by this page which has two

corrections.

Sincere1y yours,

Max

Fink, M.D.

Professor of Psychiatry

MFtkp

,

mwzg,

�</text>
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                    <text>February 1, 1968
Dr. T. P. 5. Watts
Geigy Pharmaceuticals

Ardsley,

New York

l0502

Dear Paddy.
I am

sorry

I missed you

your office you were out.
Enclosed

at lunch today.

Please read

best regards.
Sincerely yours .
Fink, M.D.
.Professor of Psychiatry
Max

MF:kp

enc .

called

is the status of the ketimipramine study

which I had planned to share with you.
and call me at your convenience.
My

When I

it

�</text>
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                    <text>February 5. 1968
Br. Henry L. Giordano

Commissioner of Narcotics
Federal Bureau of Narcotics
633 Indiana Avenue, N.H.
Washington, 0.6. 20226
Dear Mr. Giordono:

During the past year we have studied the clinical efficacy
of naloxone in the treatment of narcotic addiction. The
manufacturer, Endo Laboratories. has been unable to supply
additional material because of the expenses involved. At their
request. we are enclosing a copy of a preliminary report of our
experiences. It is my understanding that David L, Klein,
Senior Vice President of Endo Laboratories plans to discuss this
project with your office.
Your cooperation in making this compound
be appreciated.

further study will

available for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.

Hszp

�</text>
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                    <text>u

February 6, 1968
Dr. Jacques F. Remeroue

Elsevier Publishing

Company

P. 0. Box 2ll
Jan van Galenstraat 335
Amsterdam, The Netherlands
Dear Dr. Remarque:

I received Volume 28 of Progress in Brain Research and
wish to compliment you on an excellent technical production.

It

would be most useful

for

you to send the remaining

complimentary copies of the volume to
Medical College, 5 East l02nd Street.

my

ﬂew

office at the

'.»~'.Ilr'~x

York

inquire as to the policy as to the publishers with
each
of the contributors? I do not recall the contract.
to
regard
the
contributors
are not to receive a copy of the publcation
If
then I would like to send each of them a cupy. would you be kind
me what the price for additional copies are to the
enough to tell
May I

ed

tors?

u‘

"when“

New

York. new York l0029.

It

has been a pleasure to work with Elsevier.

Sincerely yours,
""I'K'rv-l-Jr'ruw'

Fink, H.D.
Professor of Psyhhiatry

Max

Mszp

�</text>
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                    <text>February 6, 1968

Jostrand
Corporation

Mr. Mayne
IBM

211 Montague

Brooklyn.

New

Street

York 11201

Dear Mr. Jostrand:

that unless the
defined
there
computer is clearly

months ago I reminded Bob Shearman

Many

billing for the
will be continuous bookkeeping
The

IBH 1800

bills

hold

are addressed to Dr.
5th Avenue

IBM

Max

difficulties.

reference 64762-06. 083081. These
Fink at the New York Medical College,

at 106th Street.

.

it

does not define the
This is unsatisfactory since
unit as separate from other units within the medical complex.
Would you

please ask your bookkeeping office to send a

all invoices for 1967 to me and arrange to have the
account readdressed as installed at the Department of Psychiatry,
New York Medical College, 5 East 102nd Street (8th floor).
copy of
New

York 10029.

Also mark the invoice to the same location.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>...

.

.m

..

ﬂ.
.,

..._,-..

alas-r

February 6. 1968
Dr. Alain Sanseigne

Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

It

was very kind of you to participate in our program on
I enjoyed very much your hospitality.
and
Friday

mentioned in our discussion, I recently came across
the following citation which will interest you.
As I

Czerwenka-wenkstetten, H. and Hoffmann. @Clinical Experiences with Helleril-retard.
Mien. Klin. Wschr., 1966, 78-48: 845-847.
Again my thanks.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

P.S.

Enclosed

is

a

the ticket with you.

ticket for “Titicut Follies.“ Please bring

�</text>
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‘n

rune-mammal

«

.mmmwr

c—‘I-wvvenrtum

February 6, 1968

-u7ﬁww

Mn‘ﬂﬂmi.m~ww—

«--

Mr. Henry N. Elliott, Editor
Annual Review of Phanmacology
4139 El Camino Hay
Palo Alto, California 94306

'm‘mw—rw-mn

v.7

r
own-«w;

v

Dear Mr.

Elliott:

Thank you very much for your kind invitation to contribute
a review on "Human EEG and PsychOpharmacological Agents" for
volume 9 of the Annual Review of Pharmacology. I am pleased

to accept your invitation and will prepare this review
the spring.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

later in

�</text>
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                    <text>a..- ...,&lt;,.

,.

.

....

-"'.1‘ n.

n;

February 6. l968
Dr. Leo E.

Hollister

Associate Chief of Staff
Veterans Administration Hospital
380l Junipero Serra Blvd.
Palo Alto, California 94308
Dear Leo,
Dr. Henry

Elliott

has invited the review of

human psychopharmacology and I am very

EEG

and

grateful for your

recommendation. In preparation for the ACNP meeting I
did complete the review until early summer l967, but I
will continue with the literature and trust that it will be
as useful as your reviews have been.
Again,

my

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 6. l968
Dr. Nathan 8. Eddy
7055 Wilson Lane
Bethesda. Maryland 20034
Dear Dr. Eddy:
Dr. Freedman wishes me

to thank

you

for your kind

comments

in your recent letter to him. He are pleased to enclose original
glossy prints of the four figures which we included in the

report

on naloxone.

As we have described in the report, naloxone appears to
us to be one of the more interesting new compounds and we

strongly recommend its continued study. Unfortunately, the
supplies have been curtailed for a variety of reasons which
seem to us alterable. He will appreciate your efforts in making

this

compound

available.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Nszp

�</text>
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                    <text>February 6. l968

9r. J. Roubicek
Psychiatric Research Institute

Prague. Czechoslovakia
Saar Dr. Roubicek:

My plans for the trip to Europa this month have
crystalized sufficiently for me to give you my itinerary.
Because of flight schedules. I will be visiting Istanbul
first and plan to arrive in Prague in the afternoon of
February 28. Because of the possibility that I may be in
Istanbul an extra day. I will cable the exact arrival
wlich will probably be on 0K 952 from Vienna at 4zl0pm.

Would

it be

too much of an imposition to have you

call one of your local hotels
me for 3 nights.
As I

wrote

originally,

and make

I am

reservations for

writing concurrently

Dr. Vojtechovsky in the hope that I can visit with
him for part of the time. Any arrangements that you
and he can make will. I am sure be agreeable.

to

My

best regards.
Sincerely yours,

Haerink, ”.8.

Professor of Psychiatry

Mszp

�</text>
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                    <text>February 7, l968
Dr. Necmettin Polvan
Abdulhak Hamid Cad 76/4

Serin Apt.
Taksim, Istanbul
Turkey

Dear Dr. Polvan:
Dr. Itil has written, I am planning to visit Istanbul
end
of February. My present plans are to leave Zurich
at the
on Swiss Air 326 on Sunday, February 25. The flight is scheduled
As

to arrive in Istanbul at 7:05
Dr.

grateful

pm.

Itil suggests that I stay at the Divan and I would be
if you would call them and make a reservation on my

Failing that, I would trust you to
at any hotel convenient for you.

behalf.

As I

understand my mission.

it

make a

reservation

is to see the patients with

you on high dose fluphenazine; to review the butaperazine project;
and to visit your hoSpital and, if possible, the Bakirkﬁy in

order to maintain our relationship with that institution.

this trip I would like to visit the laboratory of
Professor Roubicek in Prague and have scheduled a flight
from Istanbul to Prague on February 28.
On

I look forward

best regards.

to seeing you at the end of the month.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

My

�</text>
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                    <text>r
..—.~

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yum,”

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"

February 7, l968
CIA. Hispanoamericana de Turismo

Paseo de Gracia, ll
Barcelona 7, Spain
Gentlemen:

accept the reservations made for me at the Imperial
Tarraco.. It is not clear to me whether you are expecting
prepayment or not. In the meantime. please accept this
I

reservation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 7, l968
Dr. William lung

Assistant Professor of Psychiatry
Duke University Medical Center
Durham, North Carolina 27706

Dear Dr. Zung:
Both Professor Freedman and I were delighted when we
vitae. I would like very much to have

reviewed your curriculum

you

for

visit

York at
week trip

New

three

a

our expense. Unfortunately. I am leaving
this Saturday. I plan to return March 2.

is a presentation from these laboratories at a local
on March l4 and Dr. Freedman suggested that this might

There

society

visit as it will give you an opportunity
to know something of our recent work. But this is only a
suggestion. May I ask you to call my secretary at (2l2) 369~7900
Ext 245 and arrange a date which is also convenient for Dr. Freedman,
alternately to March l4, during the first week in March, except
be an appropriate day to

March 7.

It has taken me a bit more than a year to get the clinical
and laboratory facilities operational. But we now have patients
on two wards at Metropolitan Hospital and from the clinic available
for study. There are two fully equipped EEG laboratories and our
computer installation of an IBM l800. Most important to me, is
the fact that Dr. Donald M. Shapiro was appointed director of the
Biomedical Infonnation Processing Division of the Medical College.
He is co-director of the l800 unit and his larger facility (360 MOD 30)
is available for any larger data processing. This collaboration
between a computer unit. the EEG laboratories and the clinic have
been very exciting during the past few months.
join

I look forward

us soon.

to your visit

and hone

that

we

can have you

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>,

w

.,

».

. stll-rx‘nww'
.7

son an.“ nan-r" "'4’".

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ii

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Febluary 7, l968
Dr. Milos Vojtechovsky
Institute of Pharmacology
Medical Faculty of Hygiene

Charles University
Praha l0 ~ Vinohrady, Srobarova 50
Czechoslovakia
Dear Miles.

Enclosed is a cony of a letter to Frofessor Roubicek which
explains my arrangements. I want to thank you for your invitation
to stay with you. but I would prefer that I
at your most
convenient hotel. I will be grateful for anystay
arrangements
you
make with Professor Roubicek which
will penmit me to get a
personal impression of both your laboratories and your work.
I look forward to seeing you

at the

end of the month.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>WW

1,

”an,“

.mwwm.

w...”

wwqg-

m-I‘FV‘V.2}.

rs

nun-M—

”rm

.1

, .7

i

i

i

February 8, 1958
Mr. William 801d
E. R. Squibb and Sons
Georges Road
New

Brunswick.

New

Jersey 08903

Dear Mr. Bold:
w

‘4
v

i

”0"";

Enclosed is a revision of our protocoi of studies of
fiuphenaZine. These modifications are effective as of this
week and re5u1t from our recent review.

nah”,

I

.
n

would appreciate your making

this

a

matter of record.

\

Sincereiy yours,

”mks..-

.
"vi-v1."-

Max

—~
s.
A

wort.“

.m-Vyrww_

‘

A

.

w-m'vm—W—_~,n

wmmn'

Fink,

M.D.

Professor of Psychiatry

m—m‘rﬂ-mu’ﬂ

Mszp

�</text>
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                    <text>February 8, l968
Dr. Nafi Kiremitci

Jersey State Hospital
New Jersey 07746

The new

Marlboro,

Dear Rafi,

for

Enclosed are some reprints and a proposed protocol

of clopenthixal. Enough
to satisfy our initial interest, but
study is indicated.
a study

I

will call

March 5.
My

you when I

work has been done
a comparison, long term

return from Istanbul, about

best to Betty.
Sincerely yours,
Max

Fink,

M.U.

Professor of Psychiatry

Mszp

�</text>
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                    <text>February 9, l968
Dr. Nonman Pitts
Chas. Pfizer a Co., Inc.

Groton. Connecticut
Dear Dr.

Pitts:

Enclosed is a revised protocol for the continuation of

our Doxepin studies. You will note that the next group of
newly admitted anxiety cases will receive doxepin without

necessarily havtng‘a preliminary period of treatment with

doxepin.

Please

amend our

project file.

Also, thank you for the matching capsules of doxepin,
chlordiazepoxide and placebo which arrived yesterday (Thursday).
I

look forward to seeing you March 7,

3pm

at

5

East lOan St.

Sincerely yours,
Max

Fink,

M.D.

Professor of rsychiatry

MF:kp

�</text>
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                    <text>February l2, l968
Dr.

J. Hittenborne

Rutgers - The State University
26 l/2 Morrell
New Brunswick, New Hersey
Dear John,

Enclosed are two reports given in the recent

ACNP

meeting.

The report “EEG Classification of Psychoactive Compounds
in Man," is complete. The report ”EEGeand Human Psychopharmacology
IV: Clinical Antidepressants" is minus legends for Figures 7 and 8.
The third report “Neurophysiology of the Phantastica" will be a
similar review to the EEG classification of approximately 20 pages
text and lo pages citations. Unfortunately I could not
finish that before I left for Europe and rather than send you the

edited

copy from which Dr.

ask your indulgence and
Thank you

it

Itil

and I have been working, I would
should be on your desk by March 8.

for your patience.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

dictated but not signed

�</text>
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                    <text>February

l2, l968

Dr. Louis Nest

Professor of Psychiatry
University of Oklahoma School of Medicine
Oklahoma City, Oklahoma
Dear

Jolly,
My

associate,

Donald

M.

Shapiro, will be visiting

Oklahoma

City on a site visit to a computer facility late in February.
Dr. Shapiro is the director of the Division of Biomedical
Information Processing. New York Medical College. and has been
associated with me in EEG analyses since l963.

of your interest and that of your associates in
psychophysiological data handling. 1 have asked Dr. Shapiro
to try to visit your computer facility, accompanied perhaps
by a member of your staff who can discuss your ongoing programs.
I have asked Dr. Shapiro to call your office in the hope that
such a visit might be mutually rewarding.
Knowing

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>A,

w...

'33

«wt-A".

“4-4,;

Anal-

Harch 4. 1968
Dr.

Mi

1ton Tar1ao,

Secretary. Eastern Association for
Electroencephaiography

80-02 Kew Gardens Road
Kew Gardens, New York 11415
Dear Mi1t,

I take great p1easure in endorsing the membership
Dr. Aaron J. Barman in the EAEEG.

tion of

I have known Joe

for

many

appiica-

years and have foiiowed his

neurophysio1ogic studies with great interest.
surgeon with a fine research interest.

He

is

a neuro—

During the past six months I have had the opportunity
work more closeiy with him in the anaiysis of EEG data
from his brain damaged monkeys. I think the presentation
which he made at the meetings in Canada wiii 1end support

to

to this recommendation.

I endorse his appiication and iook forward to his active
participation in the association.

Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 4, l968

Drs. J. Volavka and M. Matousek
Psychiatric Research Institute
Prague 8, Czechoslovakia
Dear Drs. Volavka and Matousek:
I have written to Dr. Roubicek to thank him for his many
kindnesses during my visit but I am also taking this opportunity
to thank you for your frankness and the welcome you extended
during my visit last week. I hope that it will be possible for
you to come to New York for I think that you iill enjoy your
experiences here and I believe we can make some contributions
to quantitative electroencephalography.

taking the liberty of enclosing a copy of the book
was written as his thesis fer the
It deserved a better review than
that given by Dr. Goldman and is, in my opinion, the best
available summary of a very difficult subject. Someday Charles
Shagass will write a summary of his work and the two together
will provide the cornernstone for the neurophysiological
classification of subpopulation for the medically ill.
I am

written by Dr. Itil. This
professorial examinations.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>“an"...‘ﬂq. ,

.,.‘Mq_...‘.e.“._.x;n.,

h...

r.

...w‘

\

.

_. ..."

m,“

3 "as-..

(a, yr, ,7»,

..4 -;w.NI¥/~.:I|7_‘~rn~rw~1

v...

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v:‘.\v--

,.

My- man .

M.” ..;e, .. r

”'4

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.

..

...

March 4. l968
Dr. Hilos Vojtechovsky
Institute of Pharmacology
Medical Faculty of Hygiene

Charles University
Praha l0 - Vinohrady, Srobarova 50
Czechoslovakia

Dear Miles.

that the visit to Prague was short but it was most
enjoyable. At first, I did not think there was enough time to
visit the city and also carry out the assignment I had made for
myself in visiting different laboratories. I very much enjoyed
meeting your associates and both Dr. Fink and Benesova as serious
and sophisticated workers. You are indeed fortunate in having
their collaboration and advice.
I know

Incidentally, it was kind of you and Dr. Roubicek to have
arranged for me to speak to your Society. I have made good use
of the honorarium, for at the airport I was able to buy a vase
of cut glass which will remain at my home'as a reminder of my
exciting time in Prague.
I also want to thank you and your wife for your many kindnesses
and the fine dinner. I look forward to seeing you in Spain.
My

best personal regards.
Sincerely yours.
Fink, ”.0.
Professor of Psychiatry

Max

MF:kp

.

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                    <text>.,.

March 4. 1968

Professor

Jiri

Roubicek

Psychiatric Research Institute
Prague, Czechoslovakia
Bear Dr. Roubicek:
While my visit to Prague was very short, I enjoyed every
and returned enthusiastic with the expectation
minute of
of your visiting New York later this year. I especially enjoyed
meeting Drs. Volavka and Matousek. Their spirit and excitement
in their work was most encouraging. I hope it will be possible
for both to join you in New York.

it

After leaving you in the airport I was fortunate in finding
beautiful cut glass vase which will grace my home and remain
continuing reminder the pleasant days in Prague.

a most

as a

Please extend my thanks to your wife and daughter who were
so hospitable and who made the evening at the opera so enjoyable.
My

.A

.

best personal regards.
Sincerely yours.

A,...,,_V...

.

.
_.

,A

m.

Fink. M.D.
Professor of Psychiatry

Max

..=.

—,,....u..‘—,.—~n,

MF:kp

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                    <text>March 4. l968
Dr. Necmettin Polvan
Abdulhak Hamid Cad. 76/4 Serin Apt.
Taksim ~ Taliehane
Istanbul, Turkey
Dear Dr. Polvan:
You know that I enjoyed my visit to Istanbul
very much.
Your hospitality and that of your associates was overwhelming.
But most important, I was enthusiastic about the
progress of
the fluphenazine and butaperazine.studies.

return, I found your letter requesting some medical
supplies from the United States. I regret that I had not
received this before I left for I would surely have complied.
Please excuse me.
On my

Dr. Itil about the studies and have
plan to meet earlier in the week of the GIMP
meetings to write the report for presentation. I have told
him of the tables 1 suggested and I am sure that he
will write
to you either confirming or changing the outline.
I have

written to

suggested that

we

I look forward to seeing Miss Guven in New York

early this
yourself in the fall. Please extend my best personal
regards to Drs. Ziyalar. Yagcioglu and Songar for their courtesy

summer and

and patience during my

visit.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March

4, l968

Dr. Max Hamilton

University of Leeds
Department of ngchiatry
l5 Hyde Terrace
Leeds 2, England

The

Dear Max,

of you to think of me, but I know very little
about the University of Vermont. It is among the newer schools
situated in one of the most beautiful parts of the East. Skiing
in the winter and swimming in the summer are within twenty to
Boston and
thirty minutes of the city. It is well located for
between
talent
there is an active change of professional
Burlington and that city. As Albany achieves greater prominence
in medicine, perhaps the relationship will shift to New York.

It

was kind

recollect that George Brooks was active in that area and
perhaps you would write to him for more information. Perhaps
the best source would be still be Milt Greenblatt who seems to
know everyone in that part of the country.
I

Incidentally, in the same mail I received a letter
student, Clive Tonks, who is writing with regard to the
in menstruation.

from your
EEG

changes

Perhaps we will meet in the forthcoming meetings in Tarragona.
In the meantime. my best personal regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March

Dr. Clive

M.

4, 1968

Tonks

Research Associate

Yale University School of Medicine

Department of Psychiatry
34 Park Street

New

Haven. Connecticut 06519

Dear Dr. Tonks:

changes in the menstrual
cycle are De Barenne and Gibbs; Amer. J. Obstetric Gynecology,
l942. 1944: 672-675; Lettich and Margerison, EEG Clin. Neurophysiol.
196l, l3: 606-611; Margerison et al.. EEG Clin. Neurophytiol. l964,
l7: 540-544; and Matousek Research Reports, Psychiatric Research
Institute (Prague) 9, 1967. 223-225.
The

principal references to

EEG

In addition, there is an unpublished report by George Ulett
and you can write to him at the Missouri Institute of Psychiatry,
5400 Arsenal Street, St. Louis, Missouri 63139.
The

reprint you requested in enclosed.

Please give

my

regards to Dr. Klerman.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc .

�</text>
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                    <text>'l'ﬂlm’lfrw

mtg-“rum

rrmv-wu-ri

w

1”“

March

Dr. Zdenek Fink
Purkyne Medical Research
Hradedec Kralove

4, 1968

Institute

Prague, Czechoslovakia
Dear Dr. Fink,

I returned from my whirlwind tour of Prague to be greeted
warmly by my family despite the changes in my appearance. I
told them of my trip and I showed them the many small remembrances
from the visit to Kalicha. I want to thank you for your warm

we come.

have written to Dr. Vthechovsky I believe you have
fine research program. I hope there will be more time
at the next visit to discuss at greater length the projects
As I

a very

interest us. In the meantime I am taking the liberty of
a copy of the cholinergic report that may be of
interest.

which

enclosing

Again. many thanks.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>March

Dr.

Fletcher

5. 1968

Owens

Robins Company

A. H.

l407 Cummings Drive
Richmond 20, Virginia
Dear Dr. Owens:

have recently completed a preliminary report of our
experiences with tybamate (beatran) in the treatment of narcotic
We

addicts.

A

It was

that report is enclosed.
our conclusion that the failure to observe the
copy of

reduction in drive for Opiates

may

have been

related to the

incomplete security measures on our ward. There was some
suggestion that the tybamate was effective in some of our
patients. We decided to replicate this study under better
environmental controls.
In addition, the tybamate seemed useful in withdrawal
of patients addicted to barbiturates. For this reason we
revised our protocol.
,..,

«1.,

.

I am pleased to enclose a cepy of the preliminary report
dated December Zl, 1967 and the protocol revised January 3, 1968.

—

I want

...,-

_

.
.
.—

....

to thank you for your continuing cooperation in

this project.

..,

.,

Sincerely yours.

we"

"-1-"

..

..

-‘~7-—va~.,;

Fink. M.D.
Professor of Psychiatry

Max
a
&lt;

MF:kp

�</text>
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                    <text>March

Dr.

5. 1968

J. Hittenborn

Rutgers The State University
New Brunswick. New Jersey
—

Dear John,
IV:

With reference to our

report

Clinical Antidepressants,"

and Human Psychopharmmcology
would you please insert page 73
"EEG

immediately following page 7? I am also enclosing the legends
for figures 7 and 8, which should be inserted Just before the

references.

Thank you very much.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>rr.

,r.

r.»

memuvww

March 5, 1968

r“

u

wwyljr

,Wa—=«.Wn

Mr. Vincent L. Reyaschieri
l03~l Avion Hay

Minot

a.“

"a.”

AFB

Minot. north Dakota 5870l
Dear Mr. Ravaschieri:

‘
"
'
"
'

w,

WM"-’S""

We»

1.1-

2—way

Ware-ﬂmmr‘

Thank you for your reply to our ad in the New York Times
for a Research Assistant. We are interested in your qualifications and would like you to communicate with us further as the
time approaches for your military separation, regarding the
possibility of a position in our laboratories.
Our research involves the evaluation of changes in brain
function associated with pharmacologic agents based on digitalcomputer EEG analysis. using as subjects. psychiatric patients,
narcotic addicts, and normal volunteers. The enclosed reprints
will give you an indication of our studies.

w

We

.

look forward to hearing from you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

kp

..

‘6er

�</text>
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                    <text>March

6. 1968

Dr. Joseph G. Bird

Director of Experimental Medicine
Sterling-Winthrop Research Institute
Rensselaer, New York 12144
Dear

Joe,

The question of withdrawal symptoms upon discontinuation
of cyclazocine after extended use was discussed in the reports
published in the J.A.M.A. and to appear in the American Journal
of Psychiatry. Y3§~ﬁay recall that a variety of symptoms were
recorded by the patients upon acute withdrawal. These included
increased irritability, headaches. suspiciousness. depression.

a'hrippe-like” syndrome. The sy-ptoms persisted for one to
three days and were not serious enough to warrant treatment.

and

We concluded that in the usual treatment with
cyclazocine
the termination should be accomplished over a three to five
day period, much in the way the termination of imipramine
treatment is ordinarily concluded.

In those subjects who spontaneously stopped cyclazocine, we
have never had a complaint regarding any significant secondary
e facts.

It has been our impression that the withdrawal symptoms to
cyclazocine are of an order of magnitude and most similar to the
withdrawal symptoms reported for imipramine.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March

lilliem

6, l968

Martin
Director, Addiction Research Center
Dr.

R.

NIHH

Lexington. Kentucky
Deer

Bill,
I have read

thaoozogical
reprints are

your review of Opioid antagonists in
Review with a great deal of interest.

still

I look forward

available,

to seeing

I would be

grateful for

you next week.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Max

Mszp

If

a copy.

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                    <text>March

6, l968

Dr. Marshall Gates

Professor of Chemistry
University of Rochester
Rochester, New York
Dear Dr. Gates:

associate, Arthur Zaks. who presented the report on
at the recent NR6 meetings, reported that you had As
infonnation regarding another active narcotic antagonist.
we indicated, there is great difficulty in obtaining supplies
of naloxone and I am not optimistic that these studies will
be continued. The model of narcotic antagonism for treatment
is an interesting one and we would like to continue our studies.
For this reason. I am writing to inquire as to any
information which may be available regarding additional
antagonists.
My

naloxone

Thank you

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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