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                    <text>ﬁecember

ll,

1968

Dr. Leon Hellman

Hontefiore Hospital
210 Bainbridge Ave.
Bronx, New York

Dear Leon,

“Newborn

a paper
discussed with you, I am enclosing
Process
Pertum
Post»
and
Pre~
Sex Ratios Associated with
of
our third
one
who
is
Schizophrenia“ written by Dr. Taylor
is either a very important one,
year residents. The problem
interesting footnote.
as I think it is. or an
Dr. Gallagher would read
I would be pleased if you and opportunity for us to
arrange an
this and I would like to this
Please call me as soon
further.
discuss
to
together
get
chance to read this report.
As I

as you have had a
Science and until it
The report has been submitted to
ask you to use your
would
I
has been accepted for publication, this report.

greatest discretion in discussing

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>[WW—
I

I

-,

_

__—wmumw.w_mr-

December
Dr. Stanley
York,

Dear Dr.

l968

Feldstein
Street

255 West 88th

New

ll,

New

York l0024

Feldstein:

The International Association for Psychiatric Research
is pleased to have you as a member of its research staff
at an annual salary of $3,000.00.

to having you participate in our study
both
lDan
Street and at Gracie Square Hospital.
at
programs
I look forward

Sincerely yours,
Max

Fink, M.0.

Executive Director

Mszp

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                    <text>Decadbmr 10, 1968
Dent 3111,

I plan to be in Miami on Dacembar 12~13. and as I havu to
be in Puerto King on Daccmber 18. that: is a pessibility I will stay
ever. For that reason, I hesitate to make a apacitic date to discuaa
the fenfluraminc extancab study. If I do return on Sund‘y, Dacamber
15. I would like to man: with you on Eanday, attar your athur appointnnnc
or on Tuesday.
ﬂaw York

If I can

Hilton.

maka

it.

I will leava a message far you at the

In the aaauwhile, I will rand tha matarial you sent
and will discuss it with Br. Ittl.
My

best regards.
Sincerely yours.

”3: Fink ’

H. Do

Professor of Paychintry

:2.

William Tabor

A.ﬁ. Robina Co.
Riehmond, Va.

�</text>
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                    <text>December 6, 1968
Dr. Henry W. Elliott, M.D.
Annual Reviews, Inc.

4139 El Casino Hay
Palo Alto, California 9e306

Elliott:

Dear Dr.

It

was indeed a pleasure to prepare a review of EEG
and human psychopharnacology. The question in your letter
of December 2 is unclear. The nest suitable reviewers of
the subject of EEG and human psychopharnacology are Charles
University of
Shagass, Temple University, Turan H.

Itil,

Missouri School of Medicine, Missouri Institute of Psychiatry,
or Carl Pfeiffer. New Jersey Rents-Psychiatric Institute.
For a

or

Leo

critique, you could approach Dre.
Hollister.

A. Wikler (Lexington)

for other topics that should be reviewed in subsequent
the question, I believe the effects of
drugs on the averaged evoked potential in man and animals
would be of great interest. Dre. Ed. Domino, Charles Shagass,
or E. Roy John could, in my opinion do such a review handsonely.
Dr. Shagass has completed a review in men.
As

if that is

issues,

EEG, drugs and sleep is a most important
I do not think there is sufficient material yet
for a satisfactory review, but I may be incorrect.

The

new

area.

subject of

The EEG changes

with drugs as measured by amplitude

interaction was covered adequately in 1965 and I do not think
that sufficient new data has been published to warrant another
review at this time. The citation is Goldstein and Beck.
I trust this is responsive. Thank you once again for
kind
invitation and I trust that the review is up to
your

your standards.
'

-

Sincerely yours,
MIX Fink. MOD.
Professor of Psychiatry

Hkap

�</text>
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                    <text>December 6, 1968
Dr. Henry H. Elliott, M.D.
Annual Reviews, Inc.
4139 El Camino Way

Palo Alto, California

9&amp;306

Elliott:

Bear Dr.

It

was indeed a pleasure to prepare a review of EEG
and human paychopharmacology. The question in your letter

of December 2 is unclear. The most suitable reviewers of
the subject of EEG and human psychopharmacology are Charles
Shagaua, Temple University, Turan M. Itil, Univcroity of
ﬁisaouri School of Medicine, Missouri Institute of Psychiatry,
or Carl Pfeiffer, New Jersey Nauro-Poychiatric Institute.
For a

or

Leo

critique,

you could approach Dre. A.

Hollistor.

Hitler (Lexington)

for other topics that should be reviewed in subsequent
the question, I believe tho effects of
drugs on the averaged evoked potential in man and animals
would be of great interest. Dru. Ed. Domino, Charles Shagass,
or E. Roy John could, in my opinion do such a review handsomely.
Dr. Shagaoa has completed a reviaw in man.
As

issues,

if that is

subject of EEG, druga and sleep is a most important
I do not think there is sufficient material yet
for a satisfactory review, but I may be incorrect.
The

new

area.

The EEG changes

with drugs as measured by amplitude

interaction was covered adequately in 1965 and I do not think
that sufficient new data has been published to warrant another
review at this time. The citation is Goldstein and Back.
I trust this is responsive. Thank you once again for
kind
invitation and I trust that the review is up to
your

your standards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

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                    <text>iii

December 5, l968
Dr. Harvey Tompkins

.

Chairman. Panel on Neurology and Psychiatry
Health Research Council
Department of Hospitals

l25 North Street

New

York,

New

York l0013

hear Dr. Tompkins:
The HRC review of the proposal "Methadone in the Treatment
of Chronic Active Psychosis" was read. I am taking the opportunity
(as the suggestion of Dr. Lehr) to acquaint you with our progeam
and the reasons for our interest in this compound.

This study is part of an evaluation of centrally active
compounds to determine what relations can be defined between
drug induced EEG changes and clinical behavior in man. Most
commonly used drugs have been assessed (see review) and we
are non attempting predictive studies. Examinations of

cyclazocine. fenfluramine, thiothixene, and sulthiame have
been completed and those of doxepin, nalouone, marijuana, THCs
and heroin are in progress.
Methadone is widely used in treating opiate dependence.
have found no useful reference to its use in psychosis.
Methadone evinces EEG characteristics that warrant the prediction
that its use will be associated with a sharp reduction in active
psychosis. If true. the EEG~behavioral theories will receive

We

some affirmation; if not true. the theory will require reasseSSment.
This project is not a simple clinical evaluation, as the reviewers
imply, but a test of this hypothesis. We have carefully justified
each experiment (especially this one) to the hepartment Chairman
and the Research Committee of the Colbge.

is part of

an RIMH supported program, “Quantitative
Studies in
Psychopharmacology” ~ supported since 1962
and
in Missouri
since l967 in New York. A copy of the relevant

EEG

The study

Human

portions of the grant application, as completed in l966, are
enclosed.

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.—

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Dr. Harvey Tompkins

The

v33?

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-

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December 5, l968

-2~

rejection of this project, justified by conventional
justice neither to the Panel, nor our

catechisms does

scientific progress, nor the treatment failures who may be
helped if the method is successful. I trust the Panel will
have an opportunity to review

its

recommendation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
cc:

..

Dr. David Lehr
Dr. Alfred M. Freedman

u;

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�</text>
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                  <elementText elementTextId="102738">
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December 5. l968

Dr. Richard E. Gordon
Acting Medical Director
Computer Sciences
J. Hillis Miller Health Center

University of Florida

Gainesville, Florida
E

3260l

Dear Dick.

g

i
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wanna-Juana;

gar

.

Enclosed are the specifications for running our period
program on the IBM lBOO. It runs under the Time
Sharing Executive System (TSX) and requires a minimum of.
l6,000 locations of core storage. The associated disk file
requires 205 sectors of 23l¢ disk storage. The following is
a list of the routines required for this system and a brief
statement as to the purpose of each one;

analysis

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108-71?

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- This is the main program which reads input
parameters, initializes process and error indicators, prints
output, builds disk file and calculates means and standard
RESET

deviations.

an assembly language subroutine which samples
analog input and keeps zero cross. first derivative and amplitude
INPUT

vﬁnvnw'n

.1
2:
v

mnw-n‘bw’x’w’wxe'ﬂn-Iwrn-

W

~

is

data.

- delays sampling to allow the technician time to
previous sample.

DELAY

artefact

MYERR

- sets [/0 error indicators in

LOGBL

- writes

CONVP

- rounds numbers for printing.

w:

ar

'

on

CONNOR.

the typewriter the number of

instructions executed during each epoch.

X10 BLAST

.

_

V

.7.”

..

K

ﬂ

m"

)

�f?

E

E

-2-

Dr. Gordon

December 5, l968

FLASH flashes a light on the EEG console and waits
for the start button to be depressed before returning to RESRT.
gay - is the analog interrupt routine.

SETUP ~

sets the address for the timer interrupt.

The coreload is built as SIGMA. Sampling rate. epoch length,
analog input point, number and frequencies of bands to be analyzed
are all variable parameters entered through cards.
PAPRL from the raw

is the

name

output.
build the core load:
EEG

of the program which calculates statistics
following routines are necessary to

The

statistics
statistical data

PSTAI,~iis the main program which calculates

prints out either both the
or just the statistical data.
and

raw

data and

line

39939

~

rounds raw data and

DINIh

~

reads one record of data from the disk

prints

one

sent separately. If
additional help, please call.
The cards are being

we

on

Fink. H.D.
Professor of Psychiatry

Mszp

file.

can be of

Sincerely yours,
Max

the l443.

�</text>
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                    <text>‘3‘

December S. 1968
Dr. Richard E. Gordon
Acting Medical Director

uter Sciences

J. Hillis Miller Health Center
University of Florida

Gainesville, Florida

3260l

Dear Dick.

Enclosed are the specifications for running our period
It runs under the Time
analysis program on the IBM 1800.
and
(TSX)
requires a minimum of
Sharing Executive System

disk file
l6,000 locations of core storage. The associated
The
is
following
disk
storage.
requires 205 sectors of 23l¢
and
brief
a
system
this
for
a list of the routines required
statement as to the purpose of each one:
- This is the main program which reads input
parameters, initializes process and error indicators, prints
output, builds disk file and calculates means and standard
RESRT

deviations.

- is an assembly language subroutine whichandsamples
amplitude
and keeps zero cross. first derivative
analog input
INPUT

ata.

- delays sampling to allow the technician time to
artefact previous sample.
DELAY

sets l/O error indicators in

COMMON.

MYERR

—

LOGBL

- writes on the typewriter the number of

instructions executed during each epoch.
CONVP - rounds numbers for printing.

x10 BLAST

�‘

Dr. Gordon

-2-

December 5, 1968

- flashes a light on the EEG console and waits
for the start button to be depressed before returning to RESRT.
FLASH

the analog interrupt routine.
w - -is sets
the address
the timer
CAN

for

SETUP

interrupt.
Sampling rate. epoch length,

The coreload is built as SIGMA.
analog input point. number and frequencies of bands to be analyzed
are all variable parameters entered through cards.
PAPRL

-

from the raw

is the

name

output.
build the core load:
EEG

of the

which

calculates statistics

The f0] program
owing routines

are necessary to

PSTAT
is the main program which calculates statistics
prints out either both the raw data and statistical data
or just the statistical data.
—

and

data and prints one line on the 1443.

ROUND

- rounds

DININ

- reads one record of data from the disk

raw

The cards are being sent separately. If
additional help, please call.

we

can be of

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

file.

�</text>
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                    <text>A

w.

u

w.

.4

.“

-v—m

«Va-1.....-

vvarm-m'rm—w.

wwrwv-wu

awn—”rpm

December 4, 1968
wrzw'mrtrwv

nyx-Wiw'uﬂr'fina

v:

Dr. Arnold Kendall
Deoartuont of Psychiatry
Univ. of California at Irvin:

Irvine, California

J’f-‘l'llbr

r
H

.w

car—

Dent Arnold,

in"?

.

“.mu'rfz

.

.

rm”:

.
V

A; we diocuosod, I am enclosing thrco abntracts for the
consideration of the Fsogran Committee of tho Boeioty of Biological
Psychiatry.
and
and

will

The abstract on cetubral reactivity in the one toquostod,
be a review of tho pant for your: work in our laboratories

others.

The unilatera1~bilatora1 EC! is submitted to bring to
the attention of the Socioty son. of the new tindinga in this
reappraisal of the convulliva thetopy protein.

The maternal schizophrenia—sex of offspring report is
tho most important, potentially of the three; and probably fita boat
into the theme of experimental roooaroh in schizophrenia. I am so
impressed with the data that I on oncouraging thoso young residents
to write a definitive report and uubnit it for the prize contest of

the Society.

for a

Thank you for your considerution, and
moot successful program.

my

best wishes

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

M33

mil

�</text>
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                    <text>-'

mun

.w ~‘Y"V\‘!

warm-myur-n»:

w

:

x~151§~n~v&gt;m4w£aﬂ yo. aw.

«n» .-.v

.

x

_

,t,

,.,

,

..--.

3—»

—_‘V‘_-'~,11'.'u

-

r..._;-,.g.—

..-

..

._..

.

ym;

, Y7

.,

December 3, 1968
Dr. Savoringhauae , Editor

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New York

Dear Dr. Savoringhaua:
We are pleased to submit the report, "Liquid Butaporazinc
in the Treatment of Chronic Psychosis in a Hantal Health Clinic"
for your consideration for publication in Current Thorageutic

Research.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>E

t

E

i

December 3, 1968

1

»

i
:
{

Dr. Peter E.

Siegler,

M.D.
Company
Haines and McCallum Streets

The

National Drug

Philadelphia, Pennstlvsnia
Dear Dr.

19144

Siegler:

is a draft protocol for the study of aletamine.
divided into three parts, which are successive
approximations of the analysis of the problem.
Enclosed

It is

The initial EEG trials are designed to test the dose and
time relations of a single dose as it affects the EEG profile.
These trials provide the basis for the definitive classification
trials which are comparative with knoan standards. As soon as
the classification is defined with surety, a clinical study can
be designed and undertaken in the appropriate papulation.

this procedure may be greater than the conventional
open or double-blind clinical trial, it has some distinct
advantages in providing the conventional data as well as the
While

theoretically significant neurophysiological profile.

I will be pleased to have you visit once again to discuss
these proposals in greater detail and wish to thank you for the
opportunity to read this interesting material.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>we, ,7

—;

w‘ (

winery-en

.nﬁ-r»

..

av.v--v.~-w»—.r .. --

*-.-\

..:,-,

w—r

y,

v77". 7-9—7 '

'rw'wvv

December 3, 1968
Dear Turan and

Ali,

Enclosed are draft copies of the summary report
of the fluphenazine experiences, as sent to Dr. Rothman for his

book, "Changing Patterns in Psychiatric Care".

While I anticipate
comments, you may assume that it will be published
as submitted. As soon as I know the publisher, I will let you know.
some

editorial

My

best regards.
Sincerely yours,
Max

mil

Fink,

31.1).

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                    <text>December 2, 1968

Stetler, President
Pharmaceutical Manufacturers Association
Foundation, Inc.

Mr. C. Joseph
1155

Fifteenth Street,

N.W.

Washington, D.C. 20005
Dear Mr.

Stetler:

During the past few years

we

have

in clinical psychopharmacology in this

an unusual

a program
Department of Psychiatry.

is one, Dr. Arthur M. Zaks, who has demonstrated
talent in clinical pharmacology, both as a resident

our students

Among

established

physician and since July as a Research Fellow.
encourage additional training

scientist.
that

~

and

we

wish to

his development as

a research

am writing to request information and application forms
may be available for our participation in the faculty

I

development award program of the
Thank you

PMAF.

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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J’K'a—

.,

—.—s-_'_:

e

December 2, 1968
Dr.

J.

Douglas McLean

Director of Edication
The Provincial Hospital

Postal Station
St. John,

New

B

Brunswick

Dear Dr. McLean:
Dr. Haque was a resident physician at the St. Louis State
Hospital during l965~1966 and elected as part of his training
program, to participate in research studies at the Missouri
Institute of Psychiatry. His work was directly supervised by
Dr. Turan Itil, and my contact with him was limited to the
reports which he presented and the occasional research meetings.

‘

I found him cooperative, alert, and enthusiastic. He carried
his responsibilities well and was responsive to the needs of the
patients. He was of good spirit and enthusiasm. He was among the
better residents which the hospital produced.

m..-

"11"

1-"

mm"...

I

am

pleased to

is qualified.

recommend him

for

any

position for

ny—g-v

7

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

which he

�</text>
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,,
:1

Dr. Lee

mw-mm—z

Hollister'

Hospital
Palo Alto. California 94304
V. A.

.

Dear Leo.

t

wwmvw—

Enclosed is a draft copy of the presentation for
Pharmacology far Physicians. 1 have tried ta make it less technical,
and feel that I may have succeeded in the second half only. It
represents the synthesis of the work of tha past decada from many
laboratories and while I believe it to be true and accurate, there

is

much

that will raise

some eyebrows.

If there are portiohs that are unclear. or changes

mm

«

w

wish to make. please feel free to suggest them Or,
please sand on to Dr. Madell.

you would

if acceptable.

van-y.

n
vwl

Many thanks for the invitation and the Opportunity to
reformulate these thoughts.

Sincerely yours,

awt'an-uvrwvmrp—xwmuzn-uv—wmuc—n‘

Max
I

‘V'JIGX'CS

-

u
M

‘mw‘d'

mam

'-

.mxmr'rwmw’mnwmﬁwwmﬂmw7.

mum—w

.v‘fm-yﬁ

mf/

Fink,

H.D.

�</text>
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                    <text>wermrnrmwu

December 2, 1968
Dr.

J.

Douglas McLean

Director of Edication
Provincial Hoapitel

The

Postal Station B
St. John, New Brunswick
Dear Dr. McLean:

Dr. Hague was a resident physician at the St. Louis State
Hospital during l965~1966 and elected as part of his training
program, to participate in research studies at the Missouri
Institute of Psychiatry. His work was directly supervised by
Dr. Turan Itil, and my contact with him was limited to the
reports which he presented and the occasional research meetings.

alert, and enthusiastic. He carried
and was responsive to the needs of the
patients. He was of good spirit and enthusiasm. ﬁe was among the
better residents which the hospital produced.
I found him cooperative,

his responsibilities well
I

am

pleased to

is qualified.

recommend him

for

any

position for

Sincerely yours,

371m

(a.

r‘w-Wznhy

Max Fink, M.D.
Professor of Psychiatry

which he

�</text>
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                    <text>wmnr

.m-

'1

-"?~-':“

awn»;

'I‘R-VJV'Q

\-

w'I-na-

~

~ "l'VzH

.-

-

.‘r'.r“--3v".\

u

'wm ,

“-1“... sun r

nr'iw‘“ .3...

-

-'r"o'"7" .. an:

‘

ava- "mgr-~-

:.~-~.:.~.&lt;

7:.

.

WWIdlIb‘MK’u‘K'

ww.

'IA" vuw-«.uwv:=r

December 2, 1968
Dr. Reginald Bickford

Mayo

Clinic

Rochester, Minnesota

Dear Reg,

I

pleased that IBM has indicated a willingness to provide
for the 1969 meeting in San Diego. To provide an
Opportunity for our programs, I am attaching a capy of the
configuration of components with which our 1800 is equipped.
It is my understanding that they will provide this machine
if requested.
an

IBM

am

1800

I suggest that

you write to Dr. Wayne Jostrand, Marketing
Medical
Services, 475 Northern Blvd., Great Neck,
Representative,
New York 11021, indicating the time and place of the 1969 meeting,
and your willingness to exhibit this machine.
May

Perhaps, an announcement in the next newsletter from the
Committee on Arrangements as well as memoranda to the EEG Journal
and Trace may provide you with other workers in the field who may
wish to demonstrate their programs. As an initial guess I would
suggest you contact Ernst Rodin at the Lafayette Clinic, Niel Burch
in Houston, Walter Christ in Chapel Hill, and Bernard Salsburg in
Tulane.

I trust this is helpful.
Sincerely yours,
Fink, M.ﬂ.
Professor of Psychiatry

Max

MF:kp

-

w

.

-.

�</text>
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                    <text>December 2. 1968
Mr. C. Joseph Stetler, President
Pharmaceutical Manufacturers Association
Foundation, Inc.
'

1155

Fifteenth Street,

Washington, D.C. 20005
Dear Mr.

N.w.

Stetler:

During the past few years vs have established a program
in clinical psychopharmacology in this Department of Psychiatry.

Among

is one, Dr. Arthur M. Zaks, who has demonstrated
talent in clinical pharmacology, both as a resident

our students

an unusual

physician and since July as a Research Fellow.

we wish to
encourage additional training and his develoPment as a research

scientist.

I am writing to request information and application forms
may be available for our participation in the faculty
development award program of the PMAF.
that

Thank you

for your cOOperation.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>December 2, 1968

Dr. Robert E. Dixon, Director

Profeslional Services

Roche Laboratories
Nutley, New Jersey 07110

Dear Dr. Dixon:
Some months ago you were kind enough to send my associate,
Dr. Jovan Simeon, a copy of the "Compendium of Psychopharmacotherspy'
by Walter Poeldinger.

and

I

Dr. Simeon was kind enough to share his copy with me recently
have used the material in one section in my course in

this College.
that this volume is not available

psychopharmscology at

I

presume

bookstore and so

available, for
Thank you

my

am

writing to request

use.

a copy,

if

thgough our
one is

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

still

1

�</text>
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                    <text>Novumber 30, 1968

Dr. Dean E. Wooldridge

California Institute of Technology
Borkolpy, California
Dear Dr. ﬂooldridgc,

I

am

writing to roquont permission to use a paragraph

from your volumo, ﬂochanictl‘ggg , II an introduction to an article
that I on writing at the request of
tho editors of Pharmacologz for

thoioians. I wish to quote tho paragraph ending the summary of
Chapter 14, on page 156.

I have read the thrac volume: of your views of
biological science with considerable intorost. Our own studies,
devotod to nonsuromnnt of tho changea in brain function and in
behavior associated with the administrntion of drugs and biological
trnataont of the mentally ill, have led on to the conclusion that
small alterations in cerobral chomiutry do, indcod have profound and
monournblo

affects both

on the scalp rooordod EEG and on interporaonol
revicu for which I requcot permission to quote your
summary, is the result of out atodies and those of others and in
consistent with your message.

behavior.

The

Thank you

for your oooporation,

intorelting expositions.

and

congratulations on your
Sincerely yours,

‘,

,o.w;wk...v

Fink, M.D.
Professor of Psychiatry

Max
"

‘
-

’7”

“33"“

'-"-’-

WW

:

-‘=

"

w‘v‘r

2"”-

Wan-er-er-v

mf/

�</text>
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                    <text>November 30, 1968

Dr. Shervert Frazier
Committee on Program
Washington, D.C.
APA

Boar Show.
Thank you for your kind letter, indicating that tho
Committee had too many fine articles to present in the 1989
meeting, to be able to include this one.*

I recognize your difficulties. and am writing to bring to
your attention the unusual significance of roporto of this kind for
our society. Tho.presoot trend is for more and more governmental
rootrictihn on research, and we have had to undortako this study
in a foreign country precisely because we were unable to file on
IND

here.

Since completing this study, and the political conooquonooo
of such a venture are grout, we hovo been able to file an IND hero
and presumably can undertake the study. The problem still oxiats,
however, and an opportunity to shoro the difficulties with the
memborship was the mission of the report.
Perhaps there will be another opportunity at the wanting
to discuss the FDA~rosoarch rolotionahipo, or to describe the unusual
(indings of thin otudy. Incidentally, it in not trivial to oboervo
the safe application of a treatmont at 100 timoo the ooooptod
dosage range.
Thank you

for your kindness.
Sincerely yours,
Max

Fink, H.D.

Rofz*Vory High Dose Fluphonazino Therapy of Psychosis

�</text>
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              <elementText elementTextId="36473">
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                    <text>a

”w".

A

November 29, 1968
Mr. Alden Bober

Acting Chief Chemist
U. 8. Customs Lab.
103 3. Gay Street

Baltimore, Maryland 21202

.n~p—rvw-,-

«rug:

:swwr-n-rn

-«.-

F1."

ww..«.r—

n
.

"‘;P'.:—c":n.'aﬂmv-"-

a-wc

Wr

v-rwafP-:WWW';rm-ﬂ“

ANW~\5,A~

wmrl

v.

Dear Mr. Bober:

"

)4»

three samples, individually labeled, of

presumed marijuana substances. Ibo of these are now under
study and we request an analysis to provide definitive
reference data. The third is a sample delivered to our
Department by a substance user and an analysis, if available,
would be useful in helping us deal with other similar users.
The sample

of

THC

was

received from

NIH

(Dr. Efren).

The sample of marijuana was received from
(Dr. Scigliano).

Thank you very much

NIHH

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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  <item itemId="3649" public="1" featured="0">
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                  <elementText elementTextId="105719">
                    <text>November 29, 1968

Dr. Thomas V. Ksicher, M.D.
Geigy Pharmaceuticals
Ardslcy, New York

last

Dr. Koichct,

I hsvs read the material submittcd regarding GP 41299 with
bclicvs that we can participate in a number of studies
interact,
consistont with your goals of establishing tho potsncy and clinical
safety of this compound as a hypnotic and/or a minor tranquillizcr.
As we review the available dots. the compound hss been touted primarily
as a hypnotic and no effort is described to ascertain its other possible
and

activities.
like to

Thres types of studies are suggested, and whilc one would

rcccumcnd each of then, neither time not
personnel would permit this to he demo.

1.

EEG

profils analysis:

The EEG

available stuff

profile of

GP

41299 can

in volunteer subjects, on single oral trials. and the
spectra can be compared to a standard sedative (snobsrbitsl or
diatopcm) and to other compounds as imipramino. fsnflursminc sod
chlorpromszﬁnc. to ascertain its clinical similarity to thesc agents
at the dosages tested.

be soscsscd

2. Comparison with chlordistopoxido in the therapy of
clinical anxiety: The use of ODE as a standard in s mantcl health
clinic population has become accepted, and as hsvs undertaken studios
of other minor tranquillizsrs in comparison with this compound. A
similar study of GP 41299 should be considorsd.
3. Soporific activity in opiate withdrawal: Patients
withdrawn from opiates with methadone complain of severe insomnia.
The standard procedure is to ndoinistsr oothyprylou (Rolodex) and
this is generally acceptable. we would suggest the direct comoariscn
of mothyptylon and GP 41299 in a random sequoncs, for 3~S nights.
Acceptance by this population would icdiccts s high dcgrcc of soporific

activity.

would be pleased to undertskc any of those studies, with
study as the most profitable for you «w the study that may
add materially to your analysis of this novel compound. May I suggest
that you call my office and visit with on on December 10-12, December 16
or December 23. Unfortunstcly, I will be out of my office at the other
timss in the next tow weeks.

the

We

EEG

�u
"Jaw-'34”

Vrvw'

"r

m‘-g—-,-‘-.

«wmwamxmw—v-

Kaichar, Gutsy

'7

Thank you

..-

w

,-.

information.

November 29, 1968

for the opportunity of tevicwing this interesting

N—'r"mp~a-'..d

Sincarely yours,

“ﬂit-3’1

www—w-

s
""25:

r."

ea)"

Fink, M.D.
Frofeusor af Psyehiatty

Max

v
v.»

-

mil

In ch¢ sweat that an EEG study is of intﬂtiﬂt, I would also
recannnnd that parallal atudiau be undertaken ta determine the
affects of GP 41299 on the 'alaap«print' -« the eomputer analysis
of the allwnight sleep E36. Tia techniquas available in this
country provide more quantitative information than reflected in the
summary from Dr. Carma, ané allow a more definitiva claauificgcion
of I ate compound and its coapnrison with established alaepvproducing
agonca in quantitativn terms.
P.8.

-

v

up"

m"

"w

~

w-

~—

r;

rrw—Ivz-wm'r-w—v

«

V...

F";

«-

SW'WFMF"

J

.sv—n

Km”

mnwrmﬂwrmwawwv

vwmqmvmnwﬂl"

"Ha

�</text>
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            <elementTextContainer>
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                    <text>»

“urn-«r

x-

r

November 29, 1968

uma-w-vmx—w-wwwwa

mm»

'"v'grwamr-mnw

Mr. Alden Bober

Acting Chief Chemist
U. 5. Customs Lab.
103 S. Gay

Street

Baltimore, Maryland 21202
Dear Mr. Bober:

Attached are three samples, individually labeled, of

presumed marijuana substances. lVo of these are now under
study and we request an analysis to provide definitive
reference data. The third is a sample delivered to our
Department by a substance user and an analysis, if available,
would be useful in helping us deal with other similar users.
The sample

of

THC

was

received from

NIH

(Dr. Efren).

The sample of marijuana was received from
(Dr. Scigliano).

Thank you very much

NIMH

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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            <elementTextContainer>
              <elementText elementTextId="36502">
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                    <text>Novombor 28, 1968

Door Joyce,

plooocd to talk with you and I look forward to
Gracia
Sonata Bospito1- tho cite of our convulsive
your visit to
therapy study. on Thursday morning. I would oak that you moot
with my nooociatoo and discuss your :tudy, roviow our records and
stuéy and assist us in tho further develoonont of this program
by amounting thou: questions whioh already have no onowor.

I

won

The

on the main

hospital in at

float.

we

would

Street and our laboratory is
anticipate touting about 9:30 a.m.
620 East 76

I thall try to attond tho Eastotn EEG nesting and we
should bo ablo to make the plans-morn dofinito at that time. In the
event that I cannot coho, I can be rooohcd at 369-7900 or in
the ovoning at 516~666 5A44.
The

physician: involved are

physician and project leader; Dr.
’

and

recently amigrotod

Our

psychologist, Dr.

Jiri

from tho Prague

Dru. Riohntd Abrams. a roaident

Rouhicok. Visiting Profoooot

Psychiatric Institute;

and

Dr. Martins Green. and attending neurologist and long time ocuworkot.

I

on most

Rhea Dornbuoh

grateful for your assistance

to matting with you next weak.
My

will also attend.

Eavo a good

and look forward

flight

I

best regards to Ivor.
Sincerely yours,

Max

Fink, H.D.

�</text>
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              <elementText elementTextId="36512">
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              <elementText elementTextId="36513">
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  <item itemId="3652" public="1" featured="0">
    <fileContainer>
      <file fileId="2129">
        <src>http://exhibits.library.stonybrook.edu/mfp/files/original/9652a0b930e69aa28e2e029a02f6c50e.pdf</src>
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                  <elementText elementTextId="102755">
                    <text>Roveeber 28, 1968
Dear Joyce,
was pleased to talk with you and I look forward to
your vieit to Gracie Squero Hospital—~ the site of our convulsive
therapy study. on Thursday morning. I would not that you meet
with my associates and discus: your etudy, review our records and
stuuy and easiet us in the further development of this program
by answering those questions which already have no answer.

I

hospital in at 620 East 76 Street and our laboratory is
floor. He would ontioipete meeting about 9:30 e.u.

The

on the main

I shall try to attend the Eastern EEG meeting and no
able to make the plane not. definite at that time. In the

ohould be
ovont that I cannot cone, 1 can be reached at 369~7900 or in
the evening at 516—466 saaa.

physician: involved are Dre. Richard Abrams, a reeideut
and
physician
project leader; Dr. 11:1 Rouhtcek, Visiting Professor
and recently emigrated from the Prague Psychiatric Institute; and
Dr. Martin; Green, and attending neurologist and long time cowworker.
Our psychologist, Dr. Rhee Dornbush will also attend.
The

on moot grateful for your eonietenoe and look forward
to meeting with you next weeke Have a good flight !

I

My

best regards to Ivor.
Sincerely yours,

�</text>
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                    <text>November 23, 1968

Dr] William Tabor

A.H. Robin: 00.

Richmond, Virginia

Dan: 3111,

I look forwuré to meeting you on Hooday, December 2.
3
I will be a: a conference on ﬁatropolitan Hospital at 10‘. 00 «.m.
and will be back at my oﬁfioo at 5 East 162 Street by 11:30. Consider~
ing your appointment at 2: 45 can VD meat at noon and try to be through
~

by 2:15 p.m.

?

if that is

at 10:00 a.m.

T

not satisfactory. can

Tho tyhamnte

§

3
E

The

f
g

wo

meet Tunsday morning

protocol for

AHR~1900

'\
\.

Our

wo

can demon~17

have completed our clinical fanfluramine study but have
yet to summarize the data and to complete the cane reoorda.
We

It will be a pleasure to diocusa these projects with you.
Incidentally, both Dr. Simeon and Dr. ﬂashing: were pleased with the
exhibit in Chicago and stimulated us to look forward to another.
Please call

X‘\

has been approved and on1.y requires

laboratory data program is operational and
jatrate the next step as provided Dr. Itil last week.
f

x\

laboratory data and toport are both completodL

your aoquioaconca.

V.

"

my

office to confirm the date.
Sineeroly yours,
Max

Fink,

M. D.

�</text>
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...&lt;»

November

l9, l968

Mr. Carlos M. Rios

at Large. Manhattan
3l4 East l05th Street
New York, New York l0029
Councilman

Dear Mr. Rios:
Thank you very much

our program.

for referring

Mr. Luis Collazo

to

—.

.7

vmwwtw.

—.-

"(——

that he be admitted under commitment
procedures is not feasible since our only program is for
the treatment of opiate dependence on a voluntary basis.
In addition. patients who apply and who are under jeooardy
of imprisonment are usually unable to participate in our
Your request

treatment program since our program requires the long
term continued maintenance on narcotic antagonists.
A

member

of

my

staff indicated the various locations

In the event that these measures
have arranged for him to be
are not acceptable to him,
seen at the next available screening date.

for

immediate commitment.

we

Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>November

l9. l968

Mr. Carlos

M. Rios
Councilman at Large, Manhattan
3l4 East lOSth Street
New York. New York 10029

Dear Mr. Rios:
Thank you very much

our program.

for referring

Mr. Luis Collazo

to

that he be admitted under commitment
since our only program is for
feasible
procedures is not
the treatment of Opiate dependence on a voluntary basis.
In addition. patients who apply and who are under jeopardy
of imprisonment are usually unable to participate in our
Your request

treatment program since our program requires the long
term continued maintenance on narcotic antagonists.
A

member

of

my

staff indicated the

variOus locations

In the event that these measures
for
have arranged for him to be
we
are not acceptable to him.

immediate commitment.

seen

at the next available screening date.
Thank you for your interest.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Hszp

�</text>
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                    <text>November

l8. l968

Hr. A. Mahmood
Managing Editor
The Pakistan Medical Review
505 Quamar House, Bunder Road

Karachi. Pakistan

Dear Mr. Mahmoud:

Enclosed are two capies of our report "Psychoactive

Drugs and the Alert EEG"
Medical Review.

to

for publication in the Pakistan

its

publication and would appreciate
receiving a capy of the Review as well as the reprints you
‘suggested.
I look forward

Sincerely yours.
Fink. ".0.
Professor of Psychiatry

Max

Mszp

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                    <text>Septembea 1, 1968
Ma. A. Mahmood

Phhiotan Medical Reuimm
Kamchi, Pakistan

Dena Mn. Mahmood,'
Thank you 60&amp; you&amp; bind

in the special edition

the Pahiaxan Medicot Reuiwm.
I do not know goua fouanaz, ozonextabzy, and.ao 51nd
digﬁicutt
to know if the monk we have been angaged in wouzd Lntenaot youn
neadena. Pemhapo a ££At of tho conﬁnibuxnno to the volume

it

In the event that
doeo Lntnneot you, I «outd be
oend
paepaked to
you an «dilate entizzzd, "Paychoactive Dnugé and
the Aleat EEG”. It £5 apnaoximazezy 20 paged in £engzh, doubﬂa
apaczd; uuik.50 neéeaenczb; and adom 3—5 tabled and 5~8 giguaeo.
Such an atticta could be paepaaad by the and 05 ﬂczobam.

I

own-,1

vr

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wouzd

appneciatn knowing the

numbed 05 conLeA 05

the Reuéuo,.nep&amp;£n£5 and honoaaazum which authoao may aecetoe
in pamtécépation In thio vozume; in add£t£on to the Eiot 05

inuﬁtad conznlhuzoaa.

Thank you again 504 gout

thd £nvi£at£on.
ﬂincemezy gonad,

Fink, H.D.
Pwoﬁeoooa 05 Paychzatng

zhxx

Pineatoa, Divialon

m“!

-Hn'

it

mould be 05 help.

1:-

.:-‘='AV,'aI'-‘.r'~

invitation to pantietpate

on poochiatng 05

MF/

06

PAgchoohaamacozogg

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                    <text>r-«ar-x—rwm

an.

“an“:

uhmwzwmm-vvw’ﬂ'ﬁuﬁtwﬂ'r a -w-Iva~.‘:".w

.4

-wn;.~‘\&lt;’-'

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we. “mu-w

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A
A

warn—v."

-

r

Wk-w

"WW—«mwmvm—w

November 18. 1968

Br.

A. Mahmood

Managing Editor
The Pakistan Medical Review
505 Quamar House, Bunder Road

Karachi. Pakistan

Dear Mr. Mahmood:

Enclosed are two copies of our report "Psychoactive

Drugs and the

Alert

EEG“

Medical Random.

I look forward

receiving a copy of
suggested.

to

for publication in the Pakistan

its

publication and would appreciate
Review
the
as well as the reprints you
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

‘7'?er

«ar “—3-:

..-.-~»

“Mm-{w-‘n'nwt

.

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_

November 12. l968

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New

York

Gentlemen:

Enclosed is a capy of our report “High Dose Chlordiazepoxide
Therapy of Anxiety“ for your consideration for publication in
-Quanta: Thenapcutic Reseaach.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>November

Dr. Stanley Yolles
Uirector
Rational Institute of Mental Health

5454 Wisconsin
Chevy Chase, Maryland

Dear Dr. Yolles:

writing to ask your assistance in legally making
available supplies of marijuana for experimental research.
I am

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invited to a meeting at the national
Institute of mental Health at which studies of marijuana and
cannabinols were discussed. Following that meeting I obtained
the necessary certificates, filed various forms, protocols
In May, l967 I was

applications to hlhh, appealed to the Federal Bureau of
Narcotics and attempted to obtain supplies of marijuana through
legal channels.

and

Through the cooperation of ﬁrs. Efron and Levine of the
Psychooharmacology Research Branch. 50 ampules of THC, 10 mg
each. were made available this summer. Since an essential question
to be answered was the comparison of the effects of marijuana and
this THC product. I deferred the studies of THC. awaiting a response
from the appropriate committees at NIH. I answered the requests of
Dr. Scigiliano and filed the appropriate forms. In late August I
received a detailed inquiry from his committee. which I immediately
answered. I have not heard from that connnttee since August 23.
I deferred undertaking the studies of THC, hoping that the Committees
in Washington would respond in some direct fashion - either denying
my request, or providing me with some answer which was reasonable.
I have not heard from them and on frequent occasions I have called
and received no reply.

Recently,

to requests from your
Dr. Freedman whether our programs were under
way. At Dr. Freedman's urging, we began our studies of tetrahydrocannibanol on November l. Unfortunately, the supply of
THC is severely limited, since six of the
fifty ampules arrived
in a damaged condition, leaving us with 440 mg as our total supply.
Mr. Kavanaugh. responding

office. inquired of

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Dru Yolles

November 12, l968

«.3

for

Having no response from the Committee
some months, I would be grateful for a

from your

office or that

Committee.

or Dr. Scigiliano
forthright reply

In the event that supplies of marijuana for research are
not available from the National Institutes of Mental Health
(and having been told by the Federal Bureau of Narcotics that
Health that
it is only through the National Institute of Mental
legal supplies can be obtained) can you advise me as to an
alternate route, within the law, that would allow us to continue
this research program?
am

So far, I have hesitated to write to your office, but
encouraged to do so by your assurances in June and your

recent assurance to Professor Freedman that we may turn to
situation no longer appears tenable.

you when the

Thank you.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
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                    <text>2

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“imam!"

November 12. 1968

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New

York

Gentiemen:

Enclosed is a copy of our report “High Dose Chioroiazepoxide
Therapy of Anxiety“ for your consideration for publication in

Contact Themmuuc

Rum.

'

Sincereiy yours.

1:;

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mum-n

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Fink, M.D.
Professor of Psychiatry

Max

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                    <text>November

ll,

1968

Br. Stanley Yolles

Director

National Institutes of Mental health
5454 Wisconsin
Chevy Chase, Maryland
hour Stan,

Separately, I have written regarding the difficulty
have had in obtaining supplies of marijuana through legal
channels for research purposes. The climate which encourages
this complex bureaucratic limitation of studies in this
important public health prohlom encourages no to write
regarding an important associated problem.

we

During the past two days Dr. Paul Kielholz has lectured
New York Medical College on the subjects of narcotic
the
at
addiction and the treatment of depression. In the course of
our conversations. he shared with us recent roconnnnoations
of the special committee of the World health Organization,
of which he is a member.
-

u
.

.
..

m

k‘g?’xlllf‘;'"ld"v‘9

The

Conmittoe's formulation, as distributed by him,

is attached. indicates that cannabis has
application and that it is to be classed among

a copy of which

no medical

the habituating compounds.

inquired the evidence upon which these two decisions
Dr.
Kielholz referred me to the well known literature
based.
were
of the past centuries. He made it clear that the Committee had
acted without additional significant evidence - surely, none
that he could refer no to in the scientific literature.
When I

..

-

swamp-3m.

or

v

:

"ax-«w.»

9"!"er

Considering the difficulties which already enshroud research
in marijuana and the cannabinols. such a pronouncement, especially
if accepted by the United States representatives. would ensure a
most difficult future for research.

�.r,

‘wu-z-v

,

~—

»

,—

W "v.

.m.

”4-”.

.—«--

Iii-1h?" m-~:-'-.~,--:~.-wwhWWW-xwy“my...“ NP.

.-1

..»:W ..~.r.-.vv.wu:-v..-s.—m-vv..”wadvm-wr

»

«m»

~nS'rnY.v- -,&gt;ﬁ-v'_v'y_l'-vr.\x~

.~-.;

1

-.

,-

w.

4aW'1

-

'1-w‘_~'ﬂ 4r.

a.

wry.“

Dr. Yolles

November

—2-

ll,

1968

‘W-WW'rwl-Ivﬂvv

var

rr‘wrmv

-

wurmwrmwmr-rrr

F"

mum].

raw"

I am taking the liberty of bringing this to your attention,
in the hope that you can refer this information to the appropriate
committees of your organization, and perhaps the leading psychiatric
associations of our nation, so that this proﬁlem can be avoided.
I am sufficiently discouraged, to send copies of this letter to
the appropriate agencies myself, realizing. however, that such
a communication without the political support of offices such as
yours. will have little impact.

Thank you for any actions which may assist in relieving
this potentially serious interference with research in an

important public health problem.
My

best personal regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

.«

w

w—r- -,

mum-u

-

,

no mus.»—

�</text>
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                    <text>'\

-,-»

'V'v-sr- ~.-«mwm

a:

‘

wa—nu-rmv-mr'

“-1

tmt‘vtm'n’us; “1': w- wvmnmmmuwwwwwmv-rw

‘m'

,‘w. mm»

"pr: «gnaw-amp.“Why-“10‘.

,

~7..w:‘.~lrxr1r“ WIN-run"

Novembce 8, 1968

0e. Phizip

A.

Boyce,

Je.

Medical ainectae
Menéon Laboeatoniee, Inc.
10236 Bunkee Ridge Road

Kama Cay,

Meow 64137

Venn 0e. Boyce:

Thank you 60a yuan tattea 06 Novembea 4, concenning
pyaaualeaone. The bindieb we peopoeed éoe thee compound
weae deacueeedeuéth De. Pogge in 1965, jubt pecan to my
Leaving Micsouni. My ﬁizee contain the tezxeee to De. Pogge
and the paapoeed peatacoz, but not the phaemacatogical an
cliniceﬁ data which he eubmétted. That 5££e wee test en
Miaeauni.

Beger anbwening gone hind Lettea, I woutd appaeciate
05 the avaitabze phanmacozogicat and clinical mateaiai.

a copy

I £00k seaweed in déecueeing the pnopoccd peageam ea
coon ac I have had a chance to nead.the availabze data.
Sincecezy gauze,
Fink, M.v.
Pnoécéean 05 Paychiatey

Max

MF:kp

v

2mm

~:7-

~--»-

,-

we

n

_

2

�</text>
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                    <text>November
T0

won

IT

This

currently

3,

1968

MAY CONCERN:

is to certify that Professor Jiri
empioyed by as as

Roubicek

is

Visiting Research Professor

in the Department of Psychiatry,

New

York Medical

Coliege.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>November

7. 1968

Dr. Pau1 H. B1ach1y

Associate Professor
University of Oregon Medica1 School
3181 S.H. Sam Jackson Park Road
97201

Port1and, Oregon
Dear Pau1 .
As

is typica1 for this time of the year. there are

studies under

many

The naioxone study was begun again and we
have recent1y given as much as 600 mg a day. Protection against
antravenous heroin seems to 1ast, at this dose at least eighteen
way.

ours.

In para11e1 fashion we have continued to expiore the
efficacy of methadone in b1ocking intravenous heroin and find
that at 100 mg per day. the subjects do not obtain a euphoric
response for up to 75 -heroin. at 1east for eighteen hours
after a dose; and for- mg for at 1east 36 hours.
The duration of methadone using this criterion is 1onger
than we anticipated. and we are continuing to exp1ore the
duration and dose response. Neverthe1ess. one of my staff
has proposed a study of acetyi-nethadoi. Hith our present
methods and experience. we shou1d be equipped to assess the
re1ative merit of methadone and acety1~methado1. not only on
the c1inica1 syndrome of addiction. out in the heroin cha11enge
criterion as ue11.

Before progressing with the detai1s of a protoco1. do
think
that suppiies of acetyi-nethado1 may be avai1ab1e
you
and in what re1ative quantity? If the supp1y is very 1imited.
as I think it might be. then we wouid suggest a simp1e heroin
cha11enge study in some subjects in when we have aiready
determined the duration of effect of methadone.
Our present detai1 studies of methadone shouid be comp1eted
by the end of the year and we cou1d undertake a comparison
study in January or ear1y February. Is
realistic for us

to continue this expioration?

supp1ies are indeed 1imited to ask
supp1ies avai1al1e?
My

it
be worthwhi1e if
it
NIMH
make

Hou1d

to

the
additiona1

best regards.
Sincere1y yours.

Fink, M.0.
Professor of Psychiatry
Max

,
w

NF:kp

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                    <text>‘3'.

K’Wﬂ‘rvﬁv'v

7"“

zrlw'nf'mmvmmm—menmw

w a

WWW

a“

-=

-

mi-

muwwwwm&gt; saw-m- Vl'mmumisrnmvww

‘K’E’mf:T’WF'W'VJYI'1'5‘7‘WS-WYW‘"‘.'¢W 'A—wﬁ'. "v- n~»y~m—aw.wm.m

November

mum-

-

v-w-r.‘

4‘

'-

- m-v.

,

=»

m

a

--

...,

»

..

w --

7, l968

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
3l81 s.w. Sam Jackson Park Road
Portland, Oregon 97201
Dear Paul,
As is typical for this time of the year, there are many
studies under way. The naloxone study was begun again and we
have recently given as much as 600 mg a day. Protection against
intravenous heroin seems to last, at this dose at least eighteen

hours.

we have continued to explore the
methadone
in
of
blocking intravenous heroin and find
efficacy
that at lOO mg per day, the subjects do not obtain a euphoric
response for up to 75 mg heroin. at least for eighteen hours
after a dose; and ford‘bm’g for at least 36 hours.

In parallel fashion

duration of methadone using this criterion is longer
anticipated, and we are continuing to explore the
duration and dose response. Nevertheless. one of my staff
has preposed a study of acetyl-methadol. With our present
methods and experience. we should be equipped to assess the
relative merit of methadone and acetyl—methadol, not only on
the clinical syndrome of addiction, but in the heroin challenge
than

The

we

criterion as well.

Before progressing with the details of a protocol, do
think
that supplies of acetyl-methadol may be available
you
and in what relative quantity? If the supply is very limited,
as I think it might be, then we would suggest a simple heroin
challenge study in some subjects in whom we have already
determined the duration of effect of methadone.
Our present detail studies of methadone should be completed
by the end of the year and we could undertake a comparison
realistic for us
study in January or early February. Is
Would
be
worthwhile
to continue this exploration?
if the
it

it

supplies are indeed limited to ask
supplies available?

NIMH

to

make

additional

.ve'x

My

www-

best regards.

uni-re

Sincerely yours,
mmavww

Fink, “.0.
Professor of Psychiatry

Max
"-a',

wan-M‘mmn‘

n

Mszp

r...

w «- r-

~»

-

-~

~

;,

-

.

,

.

..

v

.

.

ma

--

»

�</text>
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                    <text>November

Dr.

Philip

7,

1968

R. A. May

Clinical Director
The Neuropsychiatric Institute
UCLA Center for the health Sciences
Los Angeles.

Dear

Califbrnia

90024

Phil.

I want to thank you for your consideration in sending
a copy of the volume “Treatment of Schizophrenia", which
I read with care and a great deal of interest. As Jonathan
Cole said in the summary, the study will probably never be

me

repeated because the conclusions clearly indicate the superiority
of biological treatment methods over milieu and psychotherapy.
In some ways, I regret that such a study had to be undertaken,
for the data which is so convincingly presented here. was well
known soon after the phenothiazine became available.
Please accept

and well completed.
My

my

congratulations

on a study well done

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp
'

r
M"

c’m‘

ermwvc:mtmw"rmwrv

?
,«g,

E's‘.fwx’.

r."

n»:

7—

�</text>
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                    <text>murmur-m

November

7.

1968

Office of Information
Nationai Institute of Heaith
Bethesda, Haryiand 20014
Gentiemen:

appreciate receiving a cony of.“NIH Almanac 1968!.
an information bookie: on the National Institutes of Health, as
described in a recent issue of Science.
He

would

Thank you.

Sincerely yours.
Fink. H.D.
Professor of Psychiatry

Hex

�</text>
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                    <text>November

Dr.

Philip

7,

1968

R. A. May

Clinical Director
The Neuropsychiatric Institute
UCLA Center for the Health Sciences
Los Angeles.

Dear

California

90024

Phil,

I want to thank you for your consideration in sending
a copy of the volume “Treatment of SchizOphrenia“, which
I read with care and a great deal of interest. As Jonathan
Cole said in the summary, the study will probably never be

me

repeated because the conclusions clearly indicate the superiority
of biological treatment methods over milieu and psychotherapy.
In some ways. I regret that such a study had to be undertaken,
for the data which is so convincingly presented here. was well
known soon after the phenothiazine became available.
Please accept

and well completed.
My

my

congratulations on a study well done

best regards.
Sincerely yours.
Fink. ”.0.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�</text>
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                    <text>.

mvmW-m

'w'n-v'H'v-w‘u-I-I

November

4, l978

my.”

rm

Dear Dr. Lehr.

,«
..

"v

Wm

v—v—a—u

V;'Wm"‘

-

Wwvv‘Wi

believe the next steps in regard to the prepriety of obtaining
support for research from the Central Intelligence Agency is to request
Dr. Hasserman to withdraw this application. Failing that, it is advisable
to obtain the opinion of the Faculty Senate.
I

-

write-4"»

r'r‘pw-WT—v

funds.

3. Regardless of the financial needs of the investigator. the
Chairman of the Department of Pediatrics exercised poor Judgment in
insisting upon an immediate recommendation. By not allowing the usual
processes of decision to take place, he precipitated an issue which is
divisive. The same results probably face the College as soon as the
public (i.e.. the Faculty, the students. and the community at large)
become aware of such a request. whether or not
is funded.

it

.

For these reasons. I recommend that the whole faculty have an
opportunity to participate in the Judgment, thereby accepting responsibility
for the conflicts that may ensue. The approved motion and the sense of the
discussion may be sent to the Dean with a request that the problem be
placed on the agenda of the next meeting of the Senate.

a

.r-arvv

“Fm"n-ﬁlv'r

~

sees this issue as a sensitive one, and
appears evenly divided as to the prepriety of the College accepting such
The Research Committee

2. The Chairman of the Department of Pediatrics acted as if the
issue was a sensitive one and obtained prior permission from the Trustees.
the President and the Dean - steps that are unusual.

r”-

&lt;

l.

Incidentally.

I

regret that

Dr. Nasserman and Dr. Freedman were

allowed to participate in the Committee's discussions. Because the
Chairman of the Department of Pediatrics exhibited an insensitivity to
this issue it may be advisable for the Chairman of the Research Committee
to share the Committee's discussion with Dr. Hainstein, who, I fear, may
be under misapprehensions regarding the basis for the decision of the
Committee (notably. his awareness that some members of the Psychiatry
and Neurology Departments do not share his scientific views). It would
be regretted if Dr. Nasserman's misjudgment of motives were to color
his reports to Dr. Neinstein, and that the Research Committee be considered
as infringing on Dr. Heinstein's academic freedoms.
Many

thanks; and

I

trust these

comments

are helpful.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

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                    <text>October 29. 1968
Dr. Alain Sanseigne
Squibb International

909 Third Avenue
New York. hen York l0022
Dear Alain.

N,

”m,

“Hymn,

Enclosed are the individual case summaries for each
of the patients in the fluphenezine decanoate - fluphenezine
enanthate crossover study. More complete case records are
available in our files and will be supplied if you wish.
These summaries indicate the essential nature of the changes
accompanying the treatment and provide the backround for

our report which

..

we

submitted

earlier.

\wq

I

”New

trust these are helpful.

,.

Sincerely yours.

4;
i.

um,

«

a~

4‘:r

Fink. M.D.
Professor of Psychiatry

Max

w

v
4v-

nut-"mm

.OL-J‘I".

bemoan

u

mun-L

-

:w/rvnwuynv

:
N«'e'm:

was:

"auger

her

[’7'

7.

Inwnwsquvmuw

MF:kp

�</text>
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                    <text>February 28, 1969
Dr. Jack Mnndelaohn

ﬁational Institute of Mental Eealth
Chevy Chhsn, Maryland

Dear Jauk,

After our fine lunch in Ghiradolli Square, and the
discussion of alcohol antagonists, I was pleased ti find the anclosed
in the evening paper, th¢ Oakland Tribung.
‘

we

If theta is anything to this approach or the

it.
Wiesbaden

could look into

Kuuehnau of

My

Do

1

compound,
you have the data of the mathods of Dr.

has: regards.
Sincurely yours,

Max

Fink, M.D.

Professor of Psychiatry
mf

�</text>
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                    <text>r
.

n...

yaw-.7

-

-—.vv.

yr’r—Mvv'nn

v

w,»

-

‘wqumr

rubrunry 25. 1969

wilhol-lun Iﬂlwlch
Chair-an. Cal-lttoo an Award.
duality of Biological Psychiatry
Galcsbnr; Btato Randarch Hotpltal
Dr.

Gal-nburg.

Illinois

SlAOl

Boar Ullhcl-dnd.

It xiv-u both A1 Prouduna and nvuclt grout plnnnarn co
nub-1t the cacloood rlporz ontttlad, "8.: Ratios of marketain Puorpcral Schisoyhrtnll - A rhyslologlcal Interaction

Bctvudn Hothnr and Fauna“ by Dru. Hichnnl Tuylor and Robert
Lariat, to: tho consldordtloa of the Connlttou on Award: for
the A. E. Itasctt award.
Dru. Taylor and Lavina are in

.
—.

v

training at our Ccllcgo. During

thcy undcrtook ludapdnd-at rosadrdh

Amwnvv’m

lath

-mwmn—a,wmrﬁv

E

1n paychopharuncology,

Al and

I

found tho rnport

at special lnrorurt. for if

furthcr :tndlad vurify tho nuggodtlonr undo, than thay provide
important cvldcnco for the blolealcnl ucchaalruo of schizophrcnln

and Inturnal—fotnl
Uh

4

projcct:

also
his. to collabordeu in the vcrltlcactoa of an
lutnroctln; rtport by aboard: lﬁwil; relating Id: of offspring
to maternal paychouiu. Finding that the local data did indeed
conflrl that ruporc. they sought ottcctn in the pout~partun
parted: and in davuloplu; soup 331-11 :05: trialu. 1h. lattor
urn umduruuy and thc data too prollnlnnry to ha in this actuary.
found

and
“-1va

that: third ycar of rtnldcacy
that: olccttvu crnlnlng period.

con-and

on Awards.

incarnationu.

this rcport to tho condtdoraclon at the

ﬂat bar: ragardr.
Sinecrnly yours.
Ha: Flak. H.B.

Professor of Psychiatry

Mlzkp

cc: A. H. Pracd-da. H.D.

Committed

�</text>
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                    <text>February 23, 1969
Dr. Richard Wittenborn

Secretary, ACNP
Rutgers University

New

Brunswick,

New

Jersey

Dear Dick,

writing in response to your inquiry concerning the
I have been among those who has asked that the
mombership limits be raised, and did so at the time the Mombarship
Committee was reporting the avallnbility of more qualified candidates
than the bywlawa allowed for election.
size of the

I am
ACNP.

artificial size of the unmborship serves little purpose,
in my View, except as a guidelino for the ﬁcmbcrship Committee. I would
prefer that the Committee be empowered to recommcnd as many members
as are qualified, raising the maximum every ﬂow years on the recommendation
of the chairman of the committee. A useful procedure would be a triennial
review of the numbership list to ask for the resignation of those who
have failed to participate in our sessions for a minimum number of
An

meetings.

Scientific Associate category has always second to no
to ho a distinction without a éifferonco, and one that lends itself to
second class feelings. If one must have such a class, let us have
many so that they will feel part of the organization.
The

’

’

With these views in mind, I hesitate-to answer the inquiry
directly, without the explanations above. Please feel free to share those

Opinions with Council members.
My

best rogarés.
Sincerely yours,
Fink, M.D.
Profossor of Psychiatry

Max

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                    <text>February 23, 1969
Dr. Carl Salaman
NIHH~Paychopharma¢nlogy Rasearch Branmh
Chavy Chung, Maryland
Den: Carl,

that

my

Karen 3

On a? raturn fram a weak'a holiday, I found a message
attendance at maetinga in the Department was required on
and a. I ragret that I V111 be unable to attand tha work~

passion plaunad for

Manday morning.

You must know

that

ﬁx. 1:11 has been most

interestnd in

the laborntcry data shaet and if you vanxd accept his participation,
1 am confident that he or Dr. Holden, hag annistant, woulé be able to

zontribute ta ch: program.

w"

’rﬂrr’uvwwt

Plaase accept

may cauae you.

my

apologiea fer any inconvenience this
Sincerely yours,

"If“.

7""

V‘

Max

Fink. M.D.

Professar of Psychiatry

mf/

�</text>
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                    <text>February 10, 1969
Dr. Frank Borgat
Walloon Laboratorioo

Croodall.

How

Joraoy

Door Frank,

In reading tho latent icons of Drug Research Roporto,
I notod the report of your lecture at ﬂoorge Washington University.
ond if tho roport to correct, I woulﬂ like to concur in your opinion.
For many years I have boon among those confused by the usual animal
pharmacologic data submitted to investigators to the basis for the
selection of drug: to: trial. Repeatedly. I have notod that the
characteristics proolatmod by one pharmacologtat as the basin for the
choice of a drug for trial. are disregarded or interpreted differently
by another.

role of

The

You know

EEG

that

measures in

man

we

have boon actively investigating the

as the basis for classifying

new

classification of cyclotoclno, fenfluramine, thiothixooo.

drugs.

nod piooxnpin by those mothoda have been countatent with the

eventual clinical observations. Perhaps the tin. has come to
investigato those data 1nd roporta systematically by an industrial
laboratory such as your own.
In any case, the report

our observatiooa.

(if oorroot) lo consistent with
slncaroly yours,
Fink, N.D.
Professor of Payohiatry

Max

of]

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                    <text>February 9. 1969
Dr. Perry Black
Johns ﬁcpkino Hospital
Bgltilora, Haryland
Dear Dr. Black.

thé page proof: of tha section of ch»
forthcoming book, chapter 10.
Enclouod

at:

There arc {cw typographical errors and than: are marked.
Thurs are non. prebleut in thg way the tax: reads, and attmr re~reading
this an Friday. Saturday and tldny. I reacted with sown caneern. I! the
vulva. is co hava wide diatribucion (and I have
does), the chaytcr

it

rctloets thc oditorn not: than mysalf.

Rance, the changal and the rntnrns noted. I

am

confident

will rccagntze the idiosyncrasies involved; baththan, the
article is written under my mama and not that of the unknown aditors.
Plans. accayt each of the changas, as marked, aven if the usage is
that

you

improper by the standard: a! the Johns ﬂopkins $resa.
Thank you

of

my

lettct

for your coopcracion.

and

my

hast ragards.

In the cvcnt chose suggestion: tr: untcnublc. tha tcacriction
of November 17, 1968 still holds.
Sincorcly yours,

Ht! Fink,

M.D.

Profs-tor at Psychintry

at!

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                    <text>November 17, 1968

Dear Dr. Black,

Enclosed are the corrected galley proofs of my contribution
to the volume 'Drugs and the Brain'. I have answered your questions
and brought the references up~to~dste. Unfortunately, I could not
follow your injunction to limit the changes to those of scientific
accuracy. I have made many corrections in the text.

In some places, your editorial assistants made useful
suggestions, and these have been accepted. In others, the corrections
clouded my meaning. I have indicated the text which I prefer, and
which must be accepted for the contribution to remain in the volume.
Despite your plea that the English specialists made corrections
which you had to accept, I remind you that the production of an
article of this type is the creation of the author; and not a

joint endeavor.

In the event that you or the editors wish to change
s single word or a single frame of punctuation, please accept this
note as a withdrawal of the complete article. The suggestions
could have been submitted to me before going to galley; and the
plea that it is too expensive to make changes new is regrettable
but completely yourr responsibility. If you have any other
suggestions, please make them in writing before setting them in
type.
For some years I have found increasing disregard of
the idiosyncrscies of authors by the 'so-cslled' specialists
asked to review the articles by scientists. If the text is
unsceeptsble,then please reject the complete text. But the
text is mine; and not that of the Johns Hookins Press. Nor, for

that matter, yours as editor.

Please honor me by returning a corrected galley proof
for my signature. If no galley proof is submitted, I must insist
that the article be withdrawn, even if you find the corrections

acceptable.

Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

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v:

.11--‘

November 17, 1968

Dear Dr. Black,

Enclosed are the corrected galley proofs of my conand the Brain'. I have answered
and
the
references
questions
brought
your
up—to~dete.

tribution to the volume, 'Drugs

text.

In

You

many

will note that I have made many corrections in the
places, the editorial assistant contributed to the

clarification of the message; in others, the corrections clouded

meaning. Despite your plea that the corrections be limited, I
insist that ALL the corrections be accepted as made. I regret
that neither you nor the editor saw fit to send me a copy of your
suggested corrections; for had I had the text before it was set
in type, much expense would have been saved.

my

must

If you or the editors feel that the corrections are
unacceptable, I request that you Withdraw this contribution and
I will submit it elsewhere. It is my belief that the author is
the principal artist in the presentation, and I insist that not
a single comma or word he changed without receiving approval in
writing. All the words appear in the dictionary, and you or
the editors are free to put them in sequences of your choice; I
choose the sequences submitted, and these sequences are my creation.
Such an endeavor is not a joint enterprise and I cannot accept the
suggestion, even by implication, that an editor, even one presumably
specially selected by the esteemed press of which you are the servant,
can alter the text.
your

I regret that I must

letter are unacceptable;

those changes that I could.
indicated, must stand.

~&lt;

insist, since the suggestions of

as are the changes. I have accepted
the corrections as

The remainder of

I trust those are acceptable.

/'-:g

Y‘s-h

1

7‘

i
-.rW-v.'r‘

31

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
MF/

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                    <text>February 6, 1969
11‘.
New

Sidney Malitz

York State Psychiatric
722 West 168th Street
New York, New York 10032

Institute

Sid,

for your invitetim. to participate
Caimittee of the APA. You knm I would ’be

Thank you very much

in the

Mutants I mast, tell you”, however, that

I have no
committees
mimosa , having usually served on the program

pleased to do so.

of varims societies.
My

best regards.
Sincerely
Mex

Fink,

yam,
M.D.

Professcr of Peydmietry

MF:kp

~05:

�</text>
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                    <text>y.

.,
”.V

M.

ww—mn‘,

w.—

wrv'v'

February
Dr. David R.

6

,

1969

Moalf

University of Colorado Modioal Center
Denver, Colorado 80220

Dear Dave ,
Having missed

the ski meeting of the Eastern EEG Society
EEG ski meeting in

poosible to attend the Western
it
Aspen. Are Eastemers accepted?
may be

If so , I would appreciate any
the time and place of the meeting.

infomtim regarding

Sincemly yours ,
Fink, NJ}.
Professor of Psychiatry
Max

MF:kp

�</text>
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              <elementText elementTextId="36822">
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                    <text>‘

“ﬂy ,. :rrxmww,

run-'rm'- ‘L-w‘“"".p-‘--W'r»w~.~\-r':.wny

Jr'r.‘-VWwyun

w

February

~./~.,.-V.~...-‘.wav-».m

”w“.

-ﬂ..‘. 7. 7,.

7.

‘

”,1. ,

MT-“ __. ,. ,...r., ”u“,

6 , 1969

Dr. Norman Pit-ts

was. Pfizer

Gmtm,

8 CO:

Cmctimt

Dear Norman,

is a swam of the clinical laboratory observatims
mien should be added to the mummy
datsd January 7 , 1969 (III) . ihis laboratory data is sumitted
Enclosed

in the omoing

Boxepin study

as a :mtter of record

mumtim.
The
My

EEG

mud

should not be

mama in any

study is going well.

best mgards.
Sincerely yours,

:1,-

Fink, Md).
meessw of Psychiatry
Max

:n

wwr

v
70.

:
r-x‘w»

Ml"
My"”gm"

«ﬂint-3'

'ma

l

30;“,

:'w"’€4&gt;".-W'H

W

mm

":1;

:kp

interim

�</text>
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                    <text>i '5l

nvm‘vmev.

‘Wia‘A—W"

,

swivw'

.

J"wwwuwm.m'mh'mwvu-Imm~v-:.v‘.‘w—rm‘ﬁw'ww'

,

wwwnw}

r—ww—.—w~

‘:-‘--wm

1.

'r

v

~

-

vnmmmvzwmmvm—wrumwmmr

Pebnmy 6,

1969

Mr. James R. Gamage

The.

Studmt Associatim
for the Study of Hallucinogena

837 College

Street

Beloit College

Wit, Wisconsin 53511
Dear Mr. Garage:

I do not have a labmtary available for the analysis
of novel &lt;11qu and I cannot be of my help in the analysis
of 3'12. Unfortunately. I do not hm of anybody who has m1
active interest in malysis of exotic drugs and would mly
hope mat one of the other consultzmta cwld help.
Sincerely yours ,

-r

.

urgvrw—qw

vm-

“WWI'I'wv-zw-

,

u,“

w;

Amgvm

‘W'.W"Prw:u&gt;r~wrr

g-r-w;

[mu-rm,-

.

MFﬂcp

ﬂax Fink, EM).

meessw of Psydxiamr

�</text>
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                    <text>-

”Fawn-V?

WWW

5:

:Tntannﬁw

Febmry s,

....

A

,-

.nmvsq—n

wwrun-a.

Dr. Sidney bialitz
Rm York State Psychiatric
722 West 18 8th

New
man-z

York,

New

Street

1959

Institute

York 10032

Dear Sid,

‘

Them you vary méh for your

imitation to particiyate

in the Amangments Omit-tee of the

APA.

You know

I wwld be

I met tell yen, however, that I have no
pleased to
experience , having usually served on the program camittew
do so.

of various societiea .
My

best mgards.

M

535.11%me

Mm:

mm

M’mp

9""

15me???

2'
&lt;_
,

{KWW-7Fﬁ'ﬂl‘r

'r‘r'vzm-

.

,w

I
n
n1
-.

”L‘WWngVMKW-ﬂﬂﬁﬂif‘pw

Fink, MD.

Professor of Psydﬁatry

wan-r,

'mmx‘my

yams ,

�</text>
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                    <text>5'me

February 4, 1969
Pharmaceutical Manufacturers Association
Foundation, Inc.
llSS Fifteenth,5t.. n.w.
Washington, 0.0. 20005
Gentlemen:
I would

like to apply

on behalf of Mr. Heywood Zeidman
stipend awarded by the PMA in the program of medical
student traineeships in clinical pharmacology.

for

a

Mr. Zeidman, a freshman medical
York Medical College, has become

student enrolled at
interested in a research
project involving narcotic antagonists. He will attempt to
develop a method of administration for naloxone and/or
cyclazocine to be released at a steady rate to provide extended
antagonism to heroin use.
New

This project will involve both laboratory and clinical
research with heroin dependent patients. He fill participate
in studies of antagonist administration, heroin challenges,
255, which are part of the treatment of heroan dependence.
He possesses a Master of Science degree in
pharmacology
and has completed many required medical school courses. He
is working with us virtually full time beginning immediatily
and ending in September 1969.

Thank you

for your cooperation.
Sincerely yours,
Fink, n.o.
Professor of Psychiatry

Max

MF:kp

�</text>
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2

, 1969

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New

Sylvan Pox

York Times

Tings Square, new York

Dear Mr. Fox,

It was a pleasure to read your balanced presentation
of the problems in marijuana resourch in today's NenIkah Timeo.
The lack of aciontific data, the need for more studios tad more funds,
and tho difficult social attitudes which affoct research were
presented in a useful tanner. You are to be congratulated on
both the content and the style of presentation.
Sincerely yours,

as:

Fink, M.D.

Professor of Psychiatry

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Medical Director

Dr. A. Wander-S.A.

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Berne, Switzerland
Dear Dr. Amsler:
Thank you for your letter of January 22. I will be out
of the city from February 14—22. I would suggest that you
for you to
call me as soon as you arrive and I will arrange
12*13.
February
have an Opportunity to visit on

I look forward to your

V531,:

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Sincerely yours,

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Fink, M.D.
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                    <text>January 31, 1969

unnu-

“35.1w."-

YA-"chev"‘!w,

0-0.2”:

mump

Dr. William P. Blackmore
Director, Clinical Pharmacology
Sterling—WinthrOp Research Institute
Reusaelacr, New York 12144
Dear Dr. Blackmore:

is in reply to your letter of January 27, reatating
your intention to withdraw the Sterling-Winthrop IND for
cyclazocine as an anti—depressant.
This

Studies of cyclazocino as an anti-depressant were
concluded in the spring of 1968 and a summary submitted to
Dr. Joseph Bird. No additional patients have been treated
with cyclazocine as a potential anti—depressant since that
summary was completed.
qu-‘e:

_.

_-..&lt;

-

"WW,

man:

The remaining supplies of cyclazocine that we used in
the treatment of depression were transfered to our narcotic
addiction treatment evaluation program and have been used in

that program.

Sincerely yours,

”,ua'uktvmrd:

(:2?!

r:

.

:A
#4:

Fink, M.D.
Professor of Psychiatry

Max

W713M72

“37:1,!

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iii-721".

MF:kp

�</text>
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                    <text>‘ﬁw:,yv'maw1ulﬁ

v-m.

--

‘IA-«rra'mw

w...

A

ww

'"an

w,

,

V’iwmmnw-m

.
__,_n

January 31. 1969

r

.

new-mm

vr-

"‘VIW'JJV'E'

I'M!"

_

Dr. Max Schnack

Department of Clinical Pharmacology
Geigy Pharmaceuticals
Ardsley, New York 10502
Dear Dr. Schneck:

-g"mv-wr-,¢V,.u.,,m.

Ir—r“

"‘

I

It

‘1‘lfiﬂ’i'vo‘vWFVWEM-rrmix-Err

"n”:

""“‘""‘"“3"-

r1:

"a"???

Yaw-CV.

[WIFE

you about IPA 2443.
when
some evidence of
from you

chatting with

would be pleased to hear

its antinarcotic activity in

animals has been accumulated.

Enclosed is a summary of the EEG classification data
as well as two reports describing the specific application

to cyclazocine.
Thank you

for bringing this problem to

my

attention.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.
r.

WW'W'JN‘aw-r

was a pleasure

ﬁFskp

�</text>
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                    <text>January 31, 1969
Dr. Alain Sanseigne
Squibb Intarnational
ﬂew York City
Dear Alaina,

It was kind of yau to sand as the translation of the
Lumbart/Midenct report, which I have read with interest, and with some'
disappointmant. The concepts are good, bit as you know already, thare
is

no data and while

I

impressed. I fear that

am

not be stimulated to look into

this ptoblam.

my

colleagues will

studies, however, shculd do much to revive interest in
the high dose problem, and I look forward to hearing of your results.
Your

that I write

will

be pleased to know that Charles Shagaaa has aakad
a short chapter on tha longwacting fluphenazines for a

You

clinical
justics 1t antics.

forthcoming review of advance» in psychopharmscology in

I hope-that I will

practice.

Yaur

lunch soon

3

My

asaiatant

do the subject tbs

sounded deliciouu over the telephone. Roé.about

best ragards.
Sincerhly yours,

Max

Fink,

M.D.

�</text>
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                  <elementText elementTextId="102794">
                    <text>January 29, i969
Miss Sfany Cuesia

lSl

Philadelphia
Dear Miss Cuesfa.
Thank you for iha spacial search, a copy of which is enclosed.
This search eiicifed game addifional arflclas of lnferesf in the
drug field, bu+ none additional for compufers and neurophysiology.
The addlflonal items from fhe drug liferalurn are welcome. The

addlflonai articlns ragarding digilai computers alone are ’mlsses'
insofar as The field of digifal compufars is very large and fhe
usefulness of fhe service would be abridgod if all were recalled,
including The many +ha+ are of inferesl +0 phases oufside my interesf.
nof sure wha? +he difference in logic is among ihe
various fypes of quesflons. The ifems of inferes? are fhosn fhaf
i

include:

am

Drugs/man

Drugs/EEG (neurophysiology/man

Drugs/ all subtypes of psychoactive
EEG/compufer/digifai
Brain/compufer digital

Brain/drugs
I

appreclale your afforfs on

my

behalf. Thank you.

Sincerely yours,

Max

Fink,

M.D.

�</text>
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                  <elementText elementTextId="102795">
                    <text>January 27, 1969
Dr. S. Carson

Food and Drug Research

58th Street and Maurice
Maspeth, New York ll378

Laboratories
'

Dear Dr. Carson:

Separately

we

for cyclazocine

are sending all the data available to

and naloxone. Three reports have been
from this laboratory and they are included as
published
wel
.
us

I would appreciate your calling me after you have had
a chance to read as much as may be pertinent to the question

of the potential solubility of each of these compounds in
silastic. so that we can arrange to discuss our interests.
Please feel free to xerox as

would appreciate the return of
you come to visit us.

much as you wish

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

but

all of the information

I
when

�</text>
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              <elementText elementTextId="36927">
                <text>1969 </text>
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                  <elementText elementTextId="102796">
                    <text>January 27, l969
Dr. Hudson Hoagland
The Worcester Foundation

for

Experimental Biology
Shrewsbury, Massachusetts 0l545
Dear Hudson.

of our resident physicians. in following a clue
described
by Shearer et al., developed some
recently
”novel" ideas about the schizophrenic process. These
concepts are based on presumed hormonal effects. As no
one here is qualified to review these critically, we are
enclosing a draft summary. I would be most grateful if you
could review the data and provide a candid opinion as to
Two

its merits.
like

In the event the material has some merit,

an opportunity
Many

we

would

to discuss the next logical steps.

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                  <elementText elementTextId="102797">
                    <text>January 25, 1969
Dr. Edgar Grunewald
Geigy Pharmaceuticals

Ardsley,
Dear

New

York ldbdz

to,

Following your request, we have reviewed our ongoing
ketimipramine~ieipramine study. This second phase was under»
taken to compare the two compounds in a random assignnent,
blind basis following the peeliminary study (Sunnery II: 8-30-65)
and the protocol (3—20—63). The study began in April lees.
To date, 26 patients in the outapatient population of the
Metropolitan Hospital Community Mental Health Center satisfied
the criterion for admission to the study of exhibiting symptoms
of depression, retardation and endogenous features. Of these,
6 are classifieo as psychotic depressions; l7 as neurotic
depressions and 3 as schizo~affective disorders with depressive
symptoms. Fourteen patients were assigned to imipramine and l2
to ketimipramine. Twelve are in progress now.
Of l4 subjects, 6 completed the study period and a were

twaa—nv

:
L

,

incomplete (“drop—out“). The “drop~outs“ were with both drugs
to drug factors. 0f 3 ketimipramine
treated patients each improved and were discharged from the

and appear unrelated

clinic.
after 5

One

of the

drop—out

patients discontinued treatment

weeks therapy, and we have not been able to obtain a
follow—up. At her last visit, her symptoms were ameliorated.

'

Three patients completed the imipramine
much improved (2) and improved (l);

rated as

trial,

being

Secondary effects were few (excluoiny the possibility that
sone patients failed to return because of symptoms assuneo to
be drug related). hith imipramine, headaches and “burning, red
eyes“ (l) and nausea (l) were reported. With ketimipramine,

‘

�January 25, 1969
Dr. Edgar Grunewald
Geigy Pharmaceuticals

Ardsley,
Dear

New

York ldbdz

to,

Following your request, we have reviewed our ongoing
ketimipramine~ieipramine study. This second phase was under»
taken to compare the two compounds in a random assignnent,
blind basis following the peeliminary study (Sunnery II: 8-30-65)
and the protocol (3—20—63). The study began in April lees.
To date, 26 patients in the outapatient population of the
Metropolitan Hospital Community Mental Health Center satisfied
the criterion for admission to the study of exhibiting symptoms
of depression, retardation and endogenous features. Of these,
6 are classifieo as psychotic depressions; l7 as neurotic
depressions and 3 as schizo~affective disorders with depressive
symptoms. Fourteen patients were assigned to imipramine and l2
to ketimipramine. Twelve are in progress now.
Of l4 subjects, 6 completed the study period and a were

twaa—nv

:
L

,

incomplete (“drop—out“). The “drop~outs“ were with both drugs
to drug factors. 0f 3 ketimipramine
treated patients each improved and were discharged from the

and appear unrelated

clinic.
after 5

One

of the

drop—out

patients discontinued treatment

weeks therapy, and we have not been able to obtain a
follow—up. At her last visit, her symptoms were ameliorated.

'

Three patients completed the imipramine
much improved (2) and improved (l);

rated as

trial,

being

Secondary effects were few (excluoiny the possibility that
sone patients failed to return because of symptoms assuneo to
be drug related). hith imipramine, headaches and “burning, red
eyes“ (l) and nausea (l) were reported. With ketimipramine,

‘

�</text>
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              <elementText elementTextId="36952">
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              <elementText elementTextId="36953">
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                    <text>.

:—

c-y.

a

r »-...,:-.....,s.

..,x..._..,W~,.H,

January 22, l969
Dr. Philip A. Boyer, Jr.
Meoical Director
Marion Laboratories, Inc.
ioaau Bunker Ridge Road
Kansas tity, Hissoori 64l37

hear hr. boyer.

‘

Thank you very much for the reprints describing studies
of orugs in hyperkinetic children. I-did find the articles
interesting and have sent them to ”W associate, Dr. SimeOn.

subject of
is unclear.
A few years ago we die administer papaverine in single doses
and were able to show changes in the ttG at a tine when
peripheral blood pressure was altered. This study did not
provide enough data to assure us of the central effects of
papaverine. There have been nuncrous studies of the effect
effects of vasooilators
increasing interest, but one for
The

on EEG

is

a

which the oata

of carbon dioxioe on ttﬁ, but these were done primarily using
visual analysis and here too the data is unsatisfactory.

investigator, John Whittier, has been interested
effects with vasodilators but his techniques are
in the
and
his studies should be replicated.
limited
The substance of these remarks is to indicate that while
the demonstration of EEG effects of vasodilators is not complete,
I believe that vasooilators will effect the Etc and that
quantitative methods could describe the changes.
Again, aw thanks for the reprints.
one

EEG

Sincerely‘yours,

Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>ﬁvw—

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,

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,7

WW

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A.

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Hawsrqu-m—_d r-r.‘ --../~

var—1......” ‘Ivuwvf‘v-"W’Y"w

mun-JW‘V

our." WF—Vva—l—

January 22, 1969
Dr. Joseph Wortis
Department of Psychiatry

Mamnides Hospital

3

é
u

I+802 Tenth Avenue
New York, New York

11219

rurzm‘r-NW‘V"

.

"WWW

Dear Joe,

I am pleased to submit the report ”Puerperal Schizophrenia,
Physiological Interaction Between Mother and Fetus” by Drs . Taylor
and Levine for your consideration for the first issue of Biological

A
—-;'—“W’

u

"‘qux

-r
‘-

Wm

P45

ychéauy.

I hope that the work of these two young men , which has been
of particular interest to ‘Al and nyself can appear in your first
issue, as I think this material is both timely, significant,
and particularly related to the message presented by our former
president , Hudson Hoagland.
Good

rV

luck in the journal.

an”

Sincerely yours ,

mum

nov-

Fink, MJ).
Professor of Psychiatry

Max

TNWF-"I‘I‘V'.

NF :kp
nxmmu-v—wrv

W”;

W

. ,

w

~

�</text>
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                  <elementText elementTextId="105722">
                    <text>January 22, 1969
Dr. Joyce: Small

lame Carter Hospital

Indianapolis, Indian

DearJoyoe,

Indmddngﬂmghsom ofxrymtee, Ifindthat

Ihadprouﬁsedyoaendymapreprint Imgretthe
delay, but enclomd are two oral-mints demibing our
prawn: View of drug classification using EEG criteria.
One report is from the Armani Rewlw 05 Phamacotow

and another, a mom pomlar version, from a forthcomng,
book ”D1133 and the Brain.

__

IoouldmtmakeSmamsinJmmy,buthopethat

IcandosoattheCentmlEﬂSmtingainMardm. Is
possible for you to send me a mpy of the program and
any other data regarding motels?
My

it

.4.

,,-_..;.‘r,.

'M..;

‘

best regards.
Sincerely yams
ﬂax Fink, M.D.

_.

Professor of Psychiatry

”79¢

‘

�</text>
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            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="36982">
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                  <elementText elementTextId="102800">
                    <text>January
ﬁr. John

22 , 1969

J. Bellini

Director, meeau of Narcotic Control
855

Central Avenue

Albany,

New

York 12206

Dear Mr. Bellizzi:
Enclosed

is

an

affidavit mega-ding the supplies of
my office at

depreaaant and stimulatory drugs in

39 Arleigﬁ‘x Road, Great Neck, New York.

position at New York I'i‘edical College , however,
we do have supplies of opiates and marijuana for our
experimcmtal purposes . If the mmlatims require an
inventory of these (huge; , please Wicate the requiremzmtc .
In

“c.”

m-

w-grw

my

wrei-

Sinccnoly yours

,3.“ng

3

ai"

-

”Kr-‘1'!”

5

Max

w
.A

v

:r-v-a;

wan-m-

5-;

r

n:.
L.-

:-

rgrgxfl‘l."

,
u

-H

,
&lt;

I;
«cum

unto-y

mar:-

Fm

0,

NJ).

Professor of Psychiatry

5-»

2‘1?sz

�</text>
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                    <text>January l8, I969
Dr. Marlin H. Keeler
The Universlfy of North Carolina
School of Medicine
Doparfmon? of Psychlafry
Chapel Hill, North Carolina
Dear Marlin:
l

#0 a

on

glad'lhal

visit

you will be Joining us and look forward
in the next few months.

Enclosed is a check for $263.00 which should cover

fhe oxponses for The visit of October l0 and December 5,
as wall as an honorarium for October l0.
Sincerely yours,
Max Fink, M.D.
Professor of Psychiafry

MF:kp

�</text>
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                    <text>January l6.

1969

Br. Carl Salzman
PsychOpharmacology Research Branch
National Institutes of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland ZOOlS
Gear Carl:
Thank you for the invitation for the June 5 ECDEU
meeting in Bethesda. I would be pleased to participate
in the panel discussion on fluphenazine enanthate. To
the extent possible, perhaps the panel should be broadened
to include fluphenazine decanoate as well. since these
two long—acting forms have many

things in

common.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

“rt:

,
,
-

,
jimmy”;

”

—

A

.3....,_.

V

M.

iﬁiw4,_.,

\

.3

an

sa
\

)

�</text>
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                    <text>January

l6.

1969

Dr. Carl Salzman

Psychopharmacology Research Branch
National Institutes of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 200l5
Bear Carl,
Enclosed are the Form 225 for each study that
RPR form for each study now in progress.

and the

is completed.

indicated

As I

earlier letter. the studies of qyclazocine, naloxone.
ketimipramine and doxepin in clinic populations are continuing.
in

RPR

my

forms

will

be submitted as soon as thuse

studies are completed.

studies I have listed our unilateral ECT
since
is on the its analysis. If this does
emphasis
study
not fit your books. just return the form.
Under the new

I have

written separately with regard to the June
Sincerely yours,

7:
v
v
-—.

Max

Fink. M.D.

Professor of Psychiatry

Wmnzsm&lt;m:Wp-vmv:

Mszp
Ame-"x:

»

«

sum-mu»:-

5

meeting.

�</text>
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                    <text>January I6, I969
Dr. Gabrlol K. Rubin
98-50 67th Avenue
Pores? Hllls, New York ll374
Dear Dr. Rubln:

If

was kind

of

you

to call

me The

other day.

you have coaplofod a survey of your pOpulaflon
be pleased To hear from you.

I

when

would

In tho moantlmo, onclosod Is a profoool of on ongoing
sfudy uhlch may be useful as a model.
Good luck!

Slnooroly yours,
Fink, M.D.
Professor of Psychlafry
Hex
MFskp

�</text>
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              <elementText elementTextId="37032">
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                    <text>January l6, I969
Dr. Ger? J. Schuller
Asslsfanf Cllnlcal Research Dlrocfor
The Squlbb lnsllluTe for Medlcal Research
New Brunswick, New Jersey 08903
Dear Dr.
.

Avryrﬂvr'pw‘:

«w

Schuller:

Separafely am sendlng you our fllo coplos of lho
record absfracfs for each case In The fluphenazine docanoafo/
enanfhafo sludles; as well as a wrlfe-ouf of fhe laborafory
I

dafao

:wﬁr"?

The lndlvlduol case records Include coples of The summary,
and vlslf records for each paTlenf in +ho sfudy.

~

«xv-a»

raflng scales

The laborafory dafa book confolns the acfual dale reporfs

WWWW

for each subJocf, lo

The exlenf colloclod durlng The sfudy period.
of lhe laborafory dafo report ls a copy of our
standards and fhls oeflnes fho upper and lower llmlfs for Thls

The
strewn-1min

flrsf sheaf

loborafory.

“3w:

,
gar-a

tyrant-arm.-

Ho would appreciate return of the records as soon as you
have complofed your review. The laboratory data slafemenfs
are The orlglnals, run for you, and tholr rofurn ls no? necessary.

Slncorely yours,

w:m%w‘r;hﬁ'ﬂw

n~

main-:1

Max

;;
r:

"m,1'f?~“

«7
:rsw‘

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-

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MP5

-,
“5mm

57¢“?u-1,

L
V.;.

A

i4’wyrnv'mlen

.732?

17/.‘c'wa

at

Flnk,

M.D.

Professor of Psychlafry

“image-n:

Mszp

�</text>
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                    <text>H.246”:

TO'
FROM'

- f
.

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS

Dr. Gerald Strahs
Dr. Max Fink

=

DATE

1/15/69

SUBJECT

Thank you for brining the symposium of the New York State
Medicai Society to my attention. If you have a copy of the
program or can obtain it, I would be glad to sent it to each
member of the Committee.
kp

�</text>
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  <item itemId="3706" public="1" featured="0">
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                    <text>1

1

A

.
_

‘

,w

WWW“

a.“

“ﬂaw“.-.ﬂ.

”......w. ., .

.._.~{.,,,.../_vmr..-.

"um. . .

..... V,._.7.,..,,,.,.... ....-.i

v .

V--wr-"fr7‘~“lmw|
x-

«w

s

,

January 15. 1969
.
my”

1

m‘prUfm-Vrlﬂrvmv-

Dr.

Philip

Boyer

iarion Laboratories. Inc.
P. 0. Box 963
Kansas

..

City. Missouri

64141

..._.

....Jﬁra‘

”aggrwm

”gum—n.”

Dear Dr. Boyer:

Enclosed is the revised protocol for the “EEG Identification
of Pyrovalerone (F 1983) Activity" as well as the FD 1572 and my

curriculum vitae.
Thank you

-

7
:vﬂv

for your interest.
Sincerely yours.

"ytfﬁwlﬂm'ﬂ‘wjr"

‘m

-

Max

v—I'T'rgw‘mr-

Wm.

"v

MF:kp

enc .

,.

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1v,»

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m

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.
,r

Fink. M.D.

Professor of Psychiatry

�</text>
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January IS, 1969

5. Treasury Deparfmenf
lnfernal Revenue Service
Mld-Aflanflc Region
U.

Genflamen:

Dr. Rhee Dornbush ls employed ln the Deparfment of
New York Medlcal College, 5 Easf l02nd_$+ree+.
While she was glven offlce space a? flls address, the

Psychlafry,

socrofarlel

and

offlce faclllfles

The work whlch she was

requlred

were

lnsufflclenf for

+0 accompllsh.

Sincerely yours,
Flnk, M.D.
Professor of Psychlafry
Max

MFskp

�</text>
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                    <text>January l3, I969
Dr. McKeen Caffell, Edllor
The Journal of Cllnlcal Pharmacology
and The Journal of New Drugs
525 Easf 681h Sfreef
New York, New York l002|
Door Dr.

Colfall:

2, regarding
wlfh regard +0 your loffor of January
#ha? fhere
advlsod
be
allowances for pago charges, please
on behalf of
ls no cafogorlcal objecflon To such charges llmlfed and no
This Deparfmenf. However, our budgefs are
usual sources
funds have been made avallable *hrough fho
such as lndusfry for Thls sfudy.
l would
Before answering your lofler afflrmaflvely,
for The
approclafo a speclflc esflmafe of lhe charges
manuscrlpf In your hands.

Slnceroly yours,
Max

Flnk, M.D.

Professor of Psychlafry

A

'1',”

2?"W:%¢:"'t‘«v74nyw-

‘ﬁ’VT-‘Pav'ﬁ'

7’

my

a?“

m»

an

gp'zﬁwww'?f1w:.j;ﬁxf.-mm.'

‘ﬁ’fm

‘

Mszp

�</text>
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                    <text>.-

,

January 10, 1969
Dr. Turnn

Itil

University of Misoouri School of Medicine
St. Louis, Missouri
Dear Turan.

Enclosed is part a! the consultation feet for your
participatinn in our program, ’EEG and Euman Psychopharmncology"
during the past few months, on your visits to our laboratories.

toes ($300) have bean requested and will be forwarded

The tamaining

promptly as received.
Many

thanks for your cantinucd

in this program.

1”,

my

1
a_—-.-

interest

and

asaistanca

best rcgards.

&lt;

“ﬂy-lava:

Sincerely yours,

«4.

-p-,

JwﬁWv-ﬂr.

Err-«(y

Max

m».;wx;n

ﬁ‘zv"w€'

mf/

Fink.

M.D.

�</text>
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                    <text>Jammy 10,

1989

Pitts

Dr. Nmaan

(has. Pfizer

8 (Emmy
Oameotiout
Gmton,

Dear

Harm,
Enclosed

.
«
u.

7.

‘W

w

told
as

you

v.w;...,-..,

y

v...“

and when

I

was

were in Europe, I canolated the report as best

I could.

mats , as always, will be most welcom.

also enclosing a revised protocol for the
definitive mt; study (12-30~68). The earlier draft
had some terms in the EEG and Clyde scale data which
are corrected in this draft. Please destroy the earlier
I

.,,,.-1-v.u—.~«_—-w

smmary requested by Mr. Fimxan.

I called your office for clarificatim,
Your

W"V‘R”,"V—“WHVV‘I’

is the

am

draft (Hemmer 29,
My

1968) and mplaoe with

this

copy.

best regards.
Sincerely yours,

”(7-1..WT,”

-7...

Fink, MD.
Professor of Psychiatry

Max

MFﬁcp

�</text>
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                    <text>Januaty 10,

1969

Dr. B. Blackwell, M.D.

8. Merrill co.
Cincinnati, Ohio

Wu.

Dear Dr. Blackwell,

I have read both the information btochuro and the proposed
protocol for otudios of Bimothocrin in dopreasivo disorders. While such
problems are of interest to this laboratory, we have recently decided that
our energies were better spent in the analysis of EEG profiles of new
compounds. to determine the logical populations of risk and the classification
'

of the compund.
Snob

special interns: to
chemical structureo, and we would be pleased

profile analyses

havo boon of

industry in the study of new
of interest to
to review the animal pharmacology of oompoundo that oro boon
decided by
hovo
you. The oloasifioation of this compound seems to
Co.
has
apparently
tho Swiso workers and the research staff of ﬁerrill
If this interpretation is incorrect. and
accepted this determination.
chore is intoroot in teviowing the population of risk for Dimethacrin,
I would be pleaood to review the data with you.
.Good luck

you

at the next

itself.

in your

ECDEU

new appointment, and

meeting, at

I look forward to meeting

earlier, if the opportunity presents
sincerely yours,

I

mf/

max Fink, M.D.

�</text>
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              <elementText elementTextId="37113">
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                  <elementText elementTextId="105724">
                    <text>January 9.
Dr. $1133 Braley

Dav Corning Center

Midland, Michigan

for

1969

Aid to Madical Egaenrch

Dear Dr. Braley.
Thank you

far your

meat infarmative éiscussian and the
reply.
wera'quite remarkable, and the patant
application for a Silicone carrier for drugs was most helpful.
It in apparent that this mathod may be useful in two of the problems
of direct interest to ua~~ the treatmaat of opiate addiction anﬁ
of chronic ptychoais. In addicts we weuld be intcrastad in the
continuous slow raleaaa at a nercatic antagohist, such as cyclazocina;
and in psychosis, the release of an antipayahntie like the cannon
prompt

The papera

phenothinminea or thiaxanthanea.

I will take the material that you nan: and prepare u ruport
to on: staff. As soon as we have giltified our interest, I truat I
may write to you for further advice.
hany thanks for tha opportunity to became acquainteé with
an important medical advance.

Sineuraly yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>January 8, 1969
Dear Jonathan,
La may be intarested in carrying
of offspring to schizophrenic mothers.
of
the
sex
studies
out concurrent
and a praprint of the report aub~
ch:
article
am
original
I
enclosing
minted to Science. An additional raport 05 the problem of poat~partum

I

am

pleaaad that Dr.

psychoais and the offagring sex is being typed and will be sent to you

shortly.

my

best regards.

E

Sincerely yours,
Mn: Fink, M.D.

Dr. Jonathan 0. Cole

Boston State Hospital
Boston, ﬁasa. 02124

�</text>
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,.—u--,wr

January 8, l969
Dr. Theodore Rothman
Executive Director
Rush Research Foundation
920l Sunset Blvd.
Los Angeles, California 90069

Dear Dr. Rotnman:
Enclosed is a corrected final draft, including a
replacement figure for our paper ”Depot Fluphenazine
Facilitation of Treatment of Psychosis" for your volume.
If you would like these corrections put on the original,
which you have, please return the original to us.

Sincerely yours.
.

"—

Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC .

7

euguuem.“

_.

e

7547.7

,,,

W”;

i

,

egg-M .4143:

g, ,

Jﬁwgﬂmnse. ”ca—Mew

7,.

e

,

A

.72..

�</text>
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                  <elementText elementTextId="102813">
                    <text>January 8, 1969
Dr. Milt Kletzkin

Wallace Laboratories
Cranbury, New Jersey
Dear
_,

,
i

A.“

Milt,

Enclosed is a draft copy of our report ”High-Dose
Tybamate Therapy of Heroin Dependence“. It is my understanding
that this is for your personal use and is not for distribution

to others until after

v
4.,

,
.«_

it

appears in the public press.

,—

Hy

best regards for the

New

Year.

("I-vmm'vwr-wgl)

Sincerely yours,
.

gar-w-aur

Max

;~m:'~r-

:m.

.

Fink,

M.D.

Professor of Psychiatry

.-

Mszp

�</text>
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                  <elementText elementTextId="102814">
                    <text>WWW

wm-

January 7. l969
Mr. James H.

Stencil

Chairmen, Board of Veterans Appeals
Hashington. 0.6. 20d20
Dear

Sir:

Re:

Buckles. Tompkin

C—l8

0116

for

Following your request to Dean

056 379

J. Frederick Eagle.

H.D.

psychiatric opinion in regard to Mr. Tonnkin
Buckles. I reviewed the records submitted in two folders one from the V.A. and one from military service. The questions
raised in your letter of December 5. l968 are. whether ﬁr. Buckles
has a chronic acquired psychiatric disorder; and if he does.
when manifestations were first shown to be present.
an independent

I have reviewed

service

these records. Hr. Buckles entered military

from a small rural community in Tennessee in July l948
the
at
age of l9. He stated he completed 8th grade. was considered
literate and achieved e score of 70 (borderline) on the Rad test
(30 July 48). He served in Japan and Korea and first sought medical
care on return to_U.S. in Aug. 52. complaining of headaches since
Jan. l952. -$ubsequently. he has repeated admissions for evaluations
of liponate and multiple somatic connlsints. interpreted as nondisabling. The record speaks of AHGL end stockede; of demotion
from Sergeant; and finally of discharge 4/54 with 30% disability

for lipomote.

The record is silent until l958; an entry in September. l962;
end l965 to date. The requests on each occasion are for increased
compensation. while the social history is sparse,
seems he
returned home and did not carry; he worked on his mother's
fern l954~l957; then went to Michigan for a loborer's Job; and

it

was

to

discharged when e strike occurred. Thereafter. he continued
for his mother.

work

�Mr.

Stencil

-2—

January 7, 1969

Various psychiatric evaluations are recorded. The first.
cost complete. is dated Aug. 5. 1952 (Fort Campbell. Ky.).
This relates chief symptoms of headaches. borderline blood pressure
and many somatic complaints. The history of headaches begins in
January 1952. The diagnosis is passive aggressive personality.
Subsequent reports are similar, none defining a more active
psychiatric condition. and each defining a personality disorder.
The record of June 1966 is the first to define more focal symptoms,
as “voices telling him to 'rubout or kill people" and 'an
alcoholic problem that had caused 4 or 5 arrests for public
and

intoxication."

other clue is present in the report of 8/23/54
alleges discharge 'for low 10“ after 6 years service.
One

which

9313.121

l.

disorder?

Does Mr. Buckles have

a chronic acquired psychiatric

record portrays an uneducated rural worker
of borderline intelligence and limited schooling. 0n induction.
his military adjustment is satisfactory. as evidenced by the sergeant’s
rating. In l952. the demands exceed his resources. 7Combined with
the thread of return to a discouraging civilin role. results in
pleas for help expressed as a plea for total support ("compensation“).
This is denied. and he adapts less and less adequately with more
somatization demands. His social. marital and Job adjustments
are equally unsatisfactory. Alcoholism is present. In the military
he was best protected. and to meet his needs he demands core
"compensation‘.
The

’

He evinces no psychiatric “disorder”, but a lifelong inadequate
adjustment. This was‘not acquired in adulthood. It was present
before military duty. It is now chronic. Based on this record,
(30l.82);
the USN-II psychiatric classification is Inad uate Personalit
retardation
secondary classification is Borderline mental

agdothe

�Hr. Stancil

2.

when worn

January 7. l969

~3—

manifestations

first

The record

indicates a ecompensa on ocaoo moo grosont?
est during the period
Jan. to August l952 and has continued.
3. gn_yhot is opinion based?

records.
I

to Professor of Psychiatry.

The
New

facts cited in the submitted

York Medical College

l966): formerly Research Professor. washingtoo University.
goince
l962-l966). Certified in Psychiatry (1954) and Neurology (l952).
Licensed to practice in ﬂow York (1946) and Missouri (l962).
Graduated New York University College of Medicine. l945.
Sincerely yours.
Max Fink, H.D.
Professor of Psychiatry

Mkap

�</text>
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                    <text>T0:

'BOARD OF VETERAN'S APPEALS

Washington, D.C.

FROM:

Fink. “.0.
Arieigh Road

Max

39

Grunt Neck,

Subject:

New

066—18-2080
York

Consultation Fee

For consuTtat1on report} dated January 6, 1969.
Tomkin Buckles
concerning
0116
C

18 056 379

$100.00

�</text>
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                  <elementText elementTextId="102816">
                    <text>January 7, l969
Dr. Thomas V. Kalcher
Gelgy Pharmaceullcals
Ardsley, New York l0502
Dear Dr. Kalcher:
GP

Enclosed Is a deflnlflve profocol for The sfudy ofTo
fhe
4l299. We would propose a slep—wlse approxlmaflon

cllnlcal evaluaflon
lf fhe

flle

program

of

lhls

for

The

compound.

lnltlal

EEG

lrlals are sallsfaclory.

lhe prolocol wlfh our Commlffees.

we

wlll

To

flle the necessary

In such slralghf—

forward sludles, approval ls generally avallable wllhln 4 weeks.
Thls wlll provlde an opportunlfy for us #0 select subjecls and
forms

for lhe

FDA.

capsules
If +hls prolocel ls accepfable, we wlll requlre 50lnacflve
of
an
25
capsules
of 25 «9 GP 4l299 and, If posslble,
dexfrose.
lacfose
or
as
placebo,
Thank you for lha opporfunlfy of preparlng lhls profmcol.
Slncerely yours,
Flnk, M.D.
Professor of Psychlalry
Max

Mszp

�</text>
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                  <elementText elementTextId="102817">
                    <text>January 7, 1969
Dr. William Guy

Biometric Laboratory
Washington, D.C.
Dear

Bill,

Enclosed is a summary of the otudies previously listed
with the Biometric Laboratory from this unit, and their preuent status.

I

have

rocently

had two

additional

members

join

my

staff

and

find that we have only one complate manual for ECDEU assessment (as
rcviaod July 1968). If othar copies are availabla, I would appreciate
two additional. If not, I will hnvu the copy xoroxed.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry
MAX

mf/

mm"4.7'-:.

.

�</text>
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                    <text>i
Iv‘v‘:&lt;

‘ru

‘

'_'.'v

I

\VC
'1‘

.z‘.
mini“

January 6, i969
Dr. Walter Essman

Department of Psychology

Queens College
Flushing, New York li367_
Dear Dr. Essman:

.Dr. Dornbush and my other associates were indeed very
grateful for your vibit to Gracie Square Hospital. The
suggestions of the biochemistry whichi may underlie memory
patterns were very illuminating and believe provide some
help in our studies of memory.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
871C .

‘

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                    <text>January 4, ‘96!
Dr. Louis Levy

Ill Park

New

S?

Haven, Connocflcu?

Dear Law,
O

am

fho notes you

sorry fha? if has Taken
requested. bu? they were

associates in Missouri
nofos are affached.

and

hava

!

me

In

so many uaoks to frack dawn
the hands of one of my

Just received

fham. Your

crigtnal

-

Whtio we aomplefad sfudtes of cyclosertna In psycboflc
paflen?s, the numbor of subjects was 100 small #0 provide a definite
E28 éa?a. Those addi?lonal s+udias «are
report wtfhour adli?tona!
}
£af+ 5+. Lauts and have not been compiefed. if Is
tn progress when
fhe lmprossion of my assactafo (and also msua) #haf cyciosarlnc may ye?
be usefu! In the symptom provecafion fraafmenf of schizophrenia.
Thanks again for fhe oppor+uni+y #0 read +hese nofes.

Sincaroiy yours,
Max

mf/

Fink,

M.D.

�</text>
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                    <text>January 2, i969
Mr. Josoph L. Packard
Packard Associates
3 Hator Lana
Monhassot, New York ii030

‘

Dear Mr. Packard:
Thank you very much for your iettor of Docombor i0.
havo discussed the opportunity which you presented with
two of my associates and so for, notthor on. is available.
i

E

i

i

shall

koop

this opportunity

in mind.

Sincerely yours,

g

f
P

i

Max

rm«..—.r

Fink,

M.D.

Professor of Psychiatry

:—-&lt;

wan—u.

‘U‘v—W'vwrw—

w—wvu—

‘

r
ru—r

~

“I'Wrrlvzur-ﬁrww‘

-—-w-

.-

Twammnm’wmmwxm-

\

Mszp

�</text>
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                    <text>January 2, [969
Dr. Craig Burrall
Sandoz Pharmaceuticals

Jersey

Hanover,

New

Dear Dr.

Burrell:

Thank you very much for recommending our program To
Dr. Quinnell. My lefter To him has gone ou? Today and
hope The? fhis program will receive +he cooperaflon of fha
P.M.A.
1

Thank you for your

inferesf.
Sincere{y yours,

Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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-

__

-.

a».

_

v“,—

—.~-.

.9, V.

,, ...w

mr.uﬁ_. vmm,_—w:r'_7

:

Aprii 29. 1969
Dr. V. G. Longo

Istituto Superioro di Sanita
Viala Regina Elena. 299

w-

Rm. Italy

‘W.,...AW,.-vaww’w-mw

Wm-"

Dear Dr. Longo:
Thank you for your invitation to participate in the
Program Committee of the CINP in Rome. I vii] be arriving
on Monday evaning May 5 and will cail you when I arrive.

Sinceraiy yours.
‘

H

Fink. H.D.
Professor of Psychiatry

Max

3

:

wm'w.rv

—&lt;—~

v-

wy-v-w-

W.

a

mu

Mszp

,

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                    <text>Apr‘l'l 29. 1969

Mrs. Werner. ECDEU
Chevy Chase Motor Lodge
8130 Wisconsin Avenue
Bethesda. Maryland 20014
Dear
and

ﬁrs.

Werner:

I look forward to attending the ECDEU meetings on June 5
1969. I have asked Dr. Jovan Sinaon to attend the

6,

meeting as wail.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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V—w«_r~___.—,v._.._,_.~._t

April 28.

v..___ -w__em. .V.

.

v..e.,e.-_r.q__ .______... ,V.___, fer.

1969

Dr. Walter Modell. Editor
Pharmacology and Therapeutics
Cornell University Medical College
1300 York Avenue
New York, New York 10021

Clinical

Dear Dr. Modell:
Many thanks for the careful review and criticism of our
report “Clinical Antidepressant Activity of Cyclazocine - A
Narcotic Antagonist“. we have adopted the specific suggestions.
which have materially improved the presentation.

It is difficult to respond to comments of redundancy and
our inadequacy. Redundancy has been reduced. but we are
reporting the observations in two studies. with different
populations, dosages. rating scales and personnel. For
accuracy, we believe it necessary to report what we know and
did. Any additional suggestions would be appreciated.
Our inadequacies are well known to us. Cyclazocine is
useful in treating opiate addiction. an illness with limited
economic interest to the pharmaceutical industry. He suggested
trials as an antidepressant based on our EEG criteria. They
were met with indifference by the representatives of Sterlingwinthrop. Our initial trial was interesting to us but to no
one else at NIHH or Sterling-Hinthrop. Recently. Schiele
and Abuzzahab have undertaken a similar study.
we carried out a second trial in a mental health clinic.
Such 0P0 studies were new to me. and we found the drop-out rate
high. At first we thought this related to cyclazocine, but we
found similar drop-out rates with other drugs and populations

in the

same

clinic.

,

V

,,

w, 77‘-.._,._,,V,._

«WV,

ﬂ ,,

,

,

,

�VFW—.WWWW “v" WW,

———.—..p

-2-

Dr. "Odell

April 28,

1969

pilot study data. reported here. was sufficiently
interesting for us to propose a direct. random assignment
study against inipranine. But we could not support this
stud . and while we vacillatad. the IND was withdrawn by
To
out a definitive study. would
The

Star ing-Hinthrop.
carry
require our own IND. new innds. 355,
But. we believe cyclazocine to be as active
.

as imipraeine.

Should

this not

be reported

-

an antidepressant
somewhere, somehow?

Incidentally. the naloxone studies have been re-instituted
(in part because of the report published in OPT) and the pilot
studies now include single daily dosages to 1500 age with
antagonistic activity observed to l8 hours against 50 mg
intravenous heroin.
I do not know

observations. It
Thank you

if

CPT

is still interested in the cyclazocine
- without prejudice. if unacceptable.

is enclosed

for your consideration

and

patience.

Sincerely yours.
Fink. H.D.
Professor of Psychiatry

Max

fokp

�</text>
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