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                    <text>October

l,

1966

Dr. Merle L. Gibson

Acting Director
Division of Neuropharmacological

Office of
&lt;-—-

v

Bureau

New

Drugs

of Medicine

Washington, D.C. 20204

“I'lrr-

.

.
,.

Dear Dr. Gibson:

HTS»

‘uaw1ﬂv-

vr'jn‘brs'

av

V.”

A.{.,_,..

~

“
V-

re“;

‘

W'mn’yaWirm-‘wna

wn.u-nw.r-vy

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It

pleasure to talk with you and I am enclosing
copies of our present laboratory out-put, the optical scan
laboratory form and a reprint of an early laboratory standards
study.
was a

submitting these materials in the hope that I may
meet with someone at the FDA who may assist me in obtaining
a better picture of the laboratory standards which should be
used as the guidelines fer new drug studies. It seems to me
that some central study of the range of laboratory tests
results seen in different populations. with different accepted
and new drugs and under no drug conditions could be most useful
in providing the necessary information for evaluation of human
I am

toxicity.

I will be in Washington on October l7 and would be pleased
to meet with you or anyone you might suggest to discuss this
further from 2 o'clock on.
.

Separately we will be sending you an
HCl. oral concentrate, lOO mg/ml.
Thank you

FD

157l

for fluphenazine

for your assistance.
Sincerely yours.
Fink. M.O.
Professor of Psychiatry

Max

Mszp

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                    <text>October 1, l968
Dr. Martin Keeler
North Carolina Memorial Hospital
Chapel Hill. North Carolina
Dear Dr. Keeler:
The Chairman of the Department. Alfred H. Freedman, M.D.,
and I look forward to having you visit on October ll. Your
lecture will be at the Metrooolitan Hospital Medical Center,
at noon. Unless I hear otherwise. I will assume that you will
need a 3 1/4 x 4 projector.

like to

meet you at Metropolitan Hospital
Avenue)
First
at 10:00 am and to show you around
before
that facility
your lecture. Dr. Freedman would like
meet
with
to
you for lunch after the lecture at l:30 pm.
I would

(97th and

I would like to arrange for you to meet with the other
members of the staff Friday afternoon. You may plan on

leaving about 4:00

I look forward

pm.

to seeing you.
Sincerely yours.
Fink. H.D.
Professor of Psychiatry
Max

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                    <text>l.

October

l968

Dr. Martin Keeler
North Carolina Memorial Hospital
Chapel Hill, North Carolina
Dear Dr. Keeler:
The Chairman of the Department, Alfred M. Freedman, M.D.,
and I look forward to having you visit on October ll. Your
lecture will be at the Metropolitan Hospital Medical Center,
at noon. Unless I hear otherwise, I will assume that you will
need a 3 l/4 x 4 projector.
I

would

like to

I

would

like to arrange for

meet you at Metropolitan Hospital
Avenue) at 10:00 am and to show you around
that facility before your lecture. Dr. Freedman would like
to meet with you for lunch after the lecture at l:30 H"-

(97th and

members

First

of the

staff

leaving about 4:00
I

you

to

Friday afternoon.

pm.

meet with the other
You may

plan on

look forward to seeing you.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>September 30, IQot
Dr. Carl Salzman
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Carl,

data.

that

HIP

Enclosed are copies of sample out—puts of our laboratory
These samples are selected from the butaperazine study
we recently completed. The output is based on the l966

laboratory data scale.

In working with that form for the past year, we have learned
both that there are important omissions, and that the form lists
many tests rarely or never performed. Based on this experience,
we have modified the form and enclose our sample copies of our

present effort.

I would ghke to suggest that duplicate outoputs and
laboratOry forms be sent to the ECDEU investigators and that
this become a subject for discussion at a meeting of the
investigators. In the event that any investigator or you
would wish to have a demonstration of the application of the
form to a definite set of data, we will be pleased to supply
the test forms and carry out the analyses.
I am

also enclosing a reprint of the controlled laboratory
As I
my associates and I completed in Hissouri.

study which

indicated, I have been concerned with the seeming peremptory
dismissal of iproniazid for the alleged effects on liver function.
The data is not too clear in this regard and much of it is
without sufficient control. If a central laboratory review
were established for a variety of new drugs, for standard drugs
and for different pOpulations under no drug conditions. then the
experience might be broad enough to provide a firmer basis for
such decisions in the future. he would like to suggest that
such a record facility be established.
Ron

I look forward to visiting you, Jerry, Bill Guy and
Sonata in hashington. hopefully on October l8. My best

regards.

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

Mszp

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                    <text>amv.—

September 30, 1968
Dr. Jerry Livine
PsychOpharmacology Research branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
‘

Dear

Jerry,

Enclosed is a copy of my letter to Carl Salzman, sample
out~puts from our laboratory data scale, samples of our
laboratory data form, and a reprint, as sent to Carl.

to visiting you and your associates on
from Europe to discuss this program.

I look forward

your return
My

best regards.
Sincerely yours,

,0»

.—

.

Fink. n.o.
Professor of Psychiatry

Max

2A

-

A

,-

p-‘M"l',l""

MF:kp

.

w

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                    <text>.-

wm—s—wwwu-m

September 30, 1968

-

rpmmrp-nn

nun

Dr. Otto Schwarzkopf

Schwarzkopf Microanalytical Laboratory
56-l9 37th Avenue
Hoodside, Mew York ll377
Dear Dr. Schwarzk0pf:
we

would appreciate your analyzing

diacetylmorphine delivered with this

that it is this

compound, would you

measures as previously to determine

It is possible that this

morphine or

inert substance.

Thank you

this

sample of

letter. Assuming
please make similar
its purity?

sample contains up to

for your cooperation.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

5%

�</text>
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                    <text>September 30, l96u

.
y
.A

my...

Dr. Ali Keskiner
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63159

1..“

..

—.—.n

._

0.."

U,"

,,
.A

_.,.

Dear

Ali,

If you receive this letter on yonr return from Eurone
without having stopped in how York. please call me. luran
and I spent yesterday afternoon talking about you and Jovan
and have volunteered your Joint services for two projects,
both of which should be completed during October.

q-

av”

i
i

He have been invited to make a demonstration of our
butaperazine work at the forthcoming Divisional APA Meeting
in Chicago. November l5-l7. He would like you and Jovan to
be prepared to attend the meeting and present the work none
in St. Louis and new York. The demonstration will include
the EEG-behavioral changes published in Comprehensive Psychiatry,
the effects on EEG and the sleep print, and our experiences with
liquid Repoise. These are our suggestions. We would like your

contribution.

have been invited to summarize our experiences with
long acting phenothiazines for a forthcoming volume on ﬁQQEEQ
Trends in Psychiatry to be edited by Ted Rothman of Los Angeles.
At first he asked for permission to reprint the report in the
Archives of General Psychiatry. Jovan, Turan and I think that
a better report would be a summary of both studies in Missouri
and our study in New York.
We

if

I have

not discussed these with you already, please
you get this letter so that I can arrange

call an as soon as
for your return to
had a nice

visit in

your decision.
My

New

York

for

Turkey and

a work session. I hope you
that your family approved of

best regards.
Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>September 30 , 1968

Daiid V. Reynolds
Conference Greiman

Mr.

Building

18

333 Ravenswood Avenue
Menlo Park, California 94025

Dear Mr. Reynolds:

associates and I have been interested in the problem
of convulsive therapy for my years and are carrying out
studies of EEG changes with unilateral and bilateral currents
in depressive patients. While I do not think that we have
sufficient data to present to your association, we would like
very much to audit the conference.
My

Would

progm?

it be possible for you to send us a copy
Sincerely yours ,
Fink, NJ).
Professor of Psychiatry

Max

of the

�</text>
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                    <text>September 30, l968
Dr. Robert N. Atkins

University of Rochester
School of medicine and Dentistry
260 Crittenden Elvd.
Rochester, new York l4620
'

Dear Dr. Atkins:
I am pleased to write this letter of recommendation
regarding Mrs. Mary Ann Stallings. Mrs. Stallings was a
research nurse with me at the Missouri Institute of Psychiatry
for more than a year in l965.

In her position with me she was responsible for co»
ordinating a new drug evaluation program. She provided the
necessary liaison between the research staff and service
staff of the Center. She maintained records and provided
data analyses at the end of the study. I found her work
most

satisfactory

and when she

left for

Topeka to accompany

continuing in his training, I was pleased
to recommend her to Br. Paul Feldman. After she had worked
with him for sometime, he not me and thanked me for both
training and recommending her.
her husband

for

I
.

any

who was

hesitation in recommending Mrs. Stallings
position of responsibility or leadership that required

would have no

initiative, understanding and tact.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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                  <elementText elementTextId="102661">
                    <text>m 'rr‘mw-wawng‘

i

..

.0.

.

.
"7.-..

v.

.,..

..&lt;
..

a

m

WWW.

September 30, 1968

._mn

,
m.

Mr. 610 Niederhold
c/o 6. H. Kays

“hwy"...u-n-n—w-m-m

Nestchester Country Club
Rye,

New

York

Dear Mr. Hiederhold:
Dr. Shapiro and I would be pleased to have you
visit with us on the morning of October l0. Since we
come in from the country ourselves, the best time would
be l0:00 am at the Computer Center, 4th Floor, 5 East

lOan Street.

Thank you very much

for sending the

Manual PL;ACHE.

Sincerely yours,

.1

ram.

w.—

nmw-n—u—w—

Max

.n

Mszp
‘av-w'31l1WI'a‘rI'vr-v

r

urn-u.

,rl'ylwn-tw

..-

mun”...

w.

_

4w:-

we

M

mm."

“mu-”mm"

wwm

a—vrmwmmma-W-

mm-r.

Fink, M.B.

Professor of Psychiatry

w-v—w-m—uw

rupwww

�</text>
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                    <text>September 30, 1968
Mr. 610 Niederhold
c/o G. H. Keys

Nestchester Country Club
Rye,

New

York

Dear Mr. Hiederhold:
Ur. Shapiro and I would be pleased to have you
with us on the morning of October 10. Since we
come in from the country ourseives. the best time would
be 10:00 am at the Computer Center. 4th Floor, 5 East
102nd Street.

visit

Thank you very much

for sending the

Manual PLzﬁﬂME.

Sincerely yours.
Max

Fink,

M.U.

Professor of Psychiatry

MF:kp

�</text>
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—.

September 30, l965
Dr. Robert N. Atkins

University of Rochester
School of Medicine and Dentistry
260 Crittenden Blvd.
Rochester, New York l4620
Dear Dr. Atkins:
I am pleased to write this letter of recommendation
regarding Mrs. Mary Ann Stallings. Mrs. Stallings was a
research nurse with me at the Missouri Institute of Psychiatry
for more than a year in l965.

In her position with me she was responsible for co—
ordinating a new drug evaluation program. She provided the
necessary liaison between the research staff and service
staff of the Center. She maintained records and provided
data analyses at the end of the study. I found her work
most

satisfactory

and when she

left for

Tapeka to accompany

her husband who was continuing in his training, I was pleased
to recommend her to Dr. Paul Feldman. After she had worked
with him for sometime, he net me and thanked me for both
training and recommending her.
I

would have no

hesitation in

recommending Mrs.

Stallings

any position of responsibility or leadership that required
initiative, understanding and tact.

for

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>.. 'w‘tn

Septaaber so , 1968

ﬁr. Daiid

V. Reynolds
Conference Gmixman

Building 18

333 Ravenswood Avenw
Menlo Park, California 94025

Dear Mr. Raynolds:
My associates and I have been interested in the problm
of convulsive therapy for many years and are carrying out
studies of EEG dmwges with milateml and bilateral
in depressive patients. While I do not think that we have
sufficient data to pmoent to your association, we would like
very web to audit the conference.

mats

Would

progm?

it be possible for you to send us

a

oopy

Sincerely yams ,
Fink, PM).
Professor of Psychiatry

Max

Firm};

of the

“VA—r—w—n‘

Ass-—

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                    <text>an,” n... V .q

September 27, 1968
Dr. Ferris Pitts
Washington University School of Medicine
Renard Hospital
4940 Audubon

St. Louis, Missouri 63ll0

Dear Pete,

to take this opportunity to thank you for the time
in
demonstrating your techniques and for the supplies
you Spent
of sodium lactate. They arrived with minimum breakage and we
have already used them in two subjects. In our initial experiences.
our observations areidentical with yours and I look forward to
the continuation of our study.
I want

it

I found my visit so interesting that I discussed
with
Dr. Freedman, who would like to invite you to give a talk to
our full staff. The subject can be a sunnmry of your studies
in anxiety, or any other aspect of your research.

There are departmental meetings every Friday at noon and
pleased if you could plan to visit at the end of
October or during November.
I would be

a

I will call you later in the
date that is acceptable.
My

week and

will try to work out

best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

H

�</text>
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                    <text>,

wt!

.e..-;_

m...-

~wxw..m_~m .- ‘. m&lt;mnvlfmw .mwpgq..."

._

“Wu-w v" 1;» .mvw': .v.w-w=w...w . a...

Haw-«~—rue—m

”n.-

..wu—w

—~-) erma—mua

n...

7...".-.

...w..;w‘w.. ”up.

September 27. l968
Dr. Ferris Pitts
Washington University School of Medicine
Renard Hospital
4940 Audubon

St. Louis. Missouri 63ll0
Dear

Pete,

you for the time
and
for the supplies
you spent in demonstrating your techniques
and we
minimum
with
breakage
arrived
sodium
of
lactate. They
have already used them in two subjects. In our initial experiences.
our observations areidentical with yours and I look forward to
I want

to take this opportunity to thank

the continuation of our study.

it

with
I found my visit so interesting that I discussed
talk
a
to
would
to
give
who
invite
like to
Dr. Freedman,
you
of
be
studies
The
can
a
summary
your
subject
our full staff.

in anxiety. or any other aspect of your research.

There are departmental meetings every Friday at noon and
pleased if you could plan to visit at the end of
October or during November.
I would be

will call you later in the
date that is acceptable.
I

a

my

week and

will try to work out

best regards.
Sincerely yours,
Fink. N.U.
Professor of Psychiatry

Max

Mszp

.

”M17”

,s

-...-.,..H.

7“,...

n...

�</text>
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                    <text>September 25. 1968
S. Karger AG
Arnold Bockiin-Strasse 25
BASEL 11

Switzerland

Gentlemen:
Enclosed are the revised page proofs.

The oni

significant

correction is in the citation for Fink, M. (5, 1964 which should
read; Eiectroonceph. ciin. Heurophysioi. Suppl. 23 (1964).
Thank you for your comment regarding reprints. Unfortunately.
I have no record of requesting reprints. We do wish to order. at
lease 100 with covers. and wouid request your sending me the
appropriate order bianks so that this can be completed. If I
already signed one. would you pioase send me a copy and I wiii
have the appropriate orders made up.

Piease excuse this extra probiem.
Thank you.

Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>September 24, 1968
Dr. Arnold J. Handell
Department of Psychiatry and Human Behavior
College of Medicine at Irvine

Irvine, California

Dear Dr. Randell:
Thank you for your kind invitation to present a report
of our current electrophysiologic work in relation to psychopathologicsl states. I very much agree with your mission of
honoring Bob Heath for his stimulating work in schizophrenia,
and I would like to participate.

nest relevant problem is the repeated observation of
differences in EEG response to barbiturates (sedation threshold
and pentothsl threshold) among different populations. The 1961
suggestion that unresponsive schizophrenic patients show their
The

lack of response to most psychoactive agents by a lack of response
to injected pentothsl has been under investigation in Missouri and
New York since 1963. The methods of analysis of the EEG have
turned out to be more complex then we first anticipated, so that
the real data available today is still meager. Nevertheless,
if the Program Committee wishes, we would be pleased to review
the problem of responsivity to barbiturates as an index of
dysfunction (altered function) of the central nervous system
in severe psychosis. we can present the recent mathematical
models for responsivity and summarize our recent experiences
in a therapy resistant study in St. Louis.
A

Mbdel

provisional title: Present Status of the Cerebral Reactivity
in Schizophrenia. The report will be written by Dr. Turen Itil

and myself.

Again,

my

thanks for your kind invitation.
Sincerely yours.
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>Scptcnbcr 25. 1968
Mrs. Pat

Halter

Bibliographic Unit
Brain Information Service
Biomedical Library
UCLA Center for the Health Scicncea
Loo Angelou,

California

90025

Dear Hrs. Whiter:

For many years I have compiled citations concerning the
effects of psychoactive drugs on the EEG. For this reason,
I am particularly intcreatcd in the bibliographies which
were listed as ready for distribution:

Effect of alcohol on the

Effects of Flaredll

on

EEG

(to

1967)

mama; Brain

Activity

Effocts of halothanc on electrical brain activity (1963068)
In addition,

wo

are interested in the manual of standardized

terminology for dhap stages of bacon subjects.
through your office?
Thank you

In

for your cooperation.
Sincerely yours,

Aw

~
.&lt;

Fink, H.D.
Professor of Psychiatry

n

Max

nnm-mrwr-mm.

'wanW—wm~1nwvw—verw-rmmwm

«awn-nu-

-

(1963-:68)

MF:kp

this available

�</text>
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                    <text>September 24, 1968
Dr. James R. Merkel

Associate Clinical Research Director
The Squibb
New

Institute for

Brunswick,

New

Medical Research
Jersey 08903

Dear Dr. Herkel :

Enclosed is the final draft copy of the report ”Depot
Fluphenezine in the Treatment of Psychosis in a Community
Mental Health Clinic" as submitted to Dr. Sanseigne for
his consideration for publication with the other reports
presented at the special meeting in Sitges. May I ask

you to destroy the

draft

copy submitted

earlier.

for the supplies of fluphenezine
enanthate. with the completion of this study. T have
reesested that all patients now receiving fluphenazine
deconoate receive, at their next visit to the clinic,
fluphenozine enenthete instead. As soon as this has been
accomplished we will destroy the remaining supplies of
fluphenazine decanoete.
Thank you very much

The summaries have been completed and as soon as they
are read and signed will be sent to you separately.
Thank you

for your cooperation.
Sincerely yours,
Fink, ”.0.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>September 26, 1968
Dr. Alain Sanaeigne

Squibb International
460 Park Avenue
New York, New York
Dear Alain,

Enclosed is a final copy of the report "Depot Pluphenarine
in the Treatment of Psychosis in a Community Mental Health Clinic."
we would be pleased to have you conaider this for publication with
the other reports from Sitgea. In the event that this publication
is not forthcoming or inordinately delayed, I would appreciate your
release of this draft for aubnieaion for publication elsewhere.
As I indicated to Dr. Morkel. we are discontinuing all
administration of fluphenarine decanoate and are transferring
patients to the ananthate form. he soon as the transfer is
complete the remaining supplies of decanoate will be destroyed.
As you know, fluphanarine enahthata is now available for clinical
use in our Center.

again, I want to thank you for the opportunity to have
and to provide both our Division and the
Department with a new and useful form of treatment.
Once

carried out this study
my

beat personal regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp
013C 0

P.S.

I think if you read this draft carefully you will find
that the difference in incidence in extrepyramidal
effects is probably as much related to dosage problems
as to the drug since we believe we used too high initial
dosages too frequently in the early (FD) phases of the study.

�</text>
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“warm

"'im—W'xvl-pfy

«nu-p.cr

.-—....-

q-..”

.-

"4%.“. up"; u—t‘rn.

uni-ll?

.mpw “Ix’.‘n\'ﬁ'v".w’~ru~'.-rvwvn

wvmmu.

.

\(-

v-:-v~v.—

~- ~

m.

~.—-v&lt;.

ww—

“-03...

September 26, 1968
U. 3. Government

Printing Office

Washington , D. C.

Gentleman:
would 11kt to order a copy of "A Manual of Standardized
Termin‘logy, Tochntquas and Scoring System for Sleep Stages of
Human subjects" as preparad by Rnchtachaffen and tales. Would
you please indicate the price or free for distribution, may we
have a copy?
Wt

Sinccrely yours,
Max

Fink, H.D.

Professor of Psychiatry

Mkap

�</text>
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                    <text>September

2&amp;,

1968

Dr. William Guy

ECDEE Coordinator for Data Analyses
The George Washington University

Biometric Laboratory
Washington, D.C. 20036
Dear

Bill,
Enclosed is the final questionnaire from my staff.
those have been helpful and look forward to a report

I trust
of the results.

Sincerely yours,
Mix Fink, M.D.

Professor of Psychiatry

“szp

�</text>
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                    <text>Saptamber 23, 1968
Dr. M1103 Vojtechavuky
Prague , Caechoslovakh
Bear 3110:,
9b are all saddened by the new: trau Prague. I wrate
to you sown wn¢ks 136 and havu not reeeivad a rayly. wandering that
pcrhtps cantorship interferes. I as taking tbs opportunity of
Dr. Itil'a visit to the wan matting and my hop: that can of your
coworkers will be permitted to ateana to sand the follawtng ta you.

Pcrhapn the tin: to lnava Gauchoslnvakin but cent. and
an. an sra prepared to 1031a: in whatever may is feasible. Tha
laboratorica hara ;re capable of supporting a few more ue1¢ntisu¢
and an wuuld b0 pleasad co 1uv1tc you to join an as a visiting
acicntiat. wt havc enquired a! sh: State Dcpartaant and they indicata
that a visa under the aéucaeional exchange programs can be and;
available within a fan vuaka. 33Gb a visa paraita tho entry of
a seientis: for periods up to 5 years. ﬂhila 1: data taquiro the
return to the naetvn country. w. havm known th:t thin can bu
waived whara tuah retarn in impracticable.

it

Visa.

may be provided through any

v.3. consul

and V.

will institute tha apwlientian forms if ynn wish and if you indicate
where they are to be taut. The visas are goad not only for the
icinntiut but h1¢ dapondaats as wall.
I trust this may not bu naccnsary. but 1! 1t 1:, pluasa
do not hasitnta to in: us know. Dru. Raubtcek and Volavka have
already written from what Garuauy.
My

heat personal regards.
Sincerely yuurs,
ma: Fink, M.D.

ml

Protessor as Psychiatry

�</text>
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                  <elementText elementTextId="102671">
                    <text>Saptamber 13. 1968
Dr. Olrich Vinnr

Psychiatric Renearch Institute
Prague, Czechoslovakia

Dear Dr. Vinar,

I wrote ragaréing she forthcoming meeting
cammittee,
program
requesting a cgange at data. Since
then. tha avnts in Prague as reported here have become more complex,
and we are sure that you are greamcupiad bw these avanta more than
tha GIMP. Knowing that hr. 1211 planned to be at aha WES meeting
to which yen have been invited, I am.taking the liberty of sanding
this lettar with him and analoaing annther fur Dr. chtechovsky. I
a! tha

Sam. waeks ago

CXNP

wanld be

grateful if

you waulﬂ

daltvnr

it

to him privately.

We are aware that tha pranent
political situation may
impede you: grograma in your laboratnriaa. Ha have discussed this
pruhlam at lengzh beta, and we are praparad to offer you an
oppartvnity to continne yaur studies hare. If you wish to join us
in ﬂaw York (at wish re join another laboratory in the U.S.) we

.
.
.
.

will file the neeesmary foxmg tn ynrmit yam to entar this country.
At the pregame time. the State Departmﬁnt 15 aooperativa and will
ﬂak: visas tor scicntifie workers available with m1n1mnm.da1ay
(2-3 vaeka) under the REP-66 exchange student/teaching prograas.
If you will write, at indicate to 9:. 1:11 that such a stem is
in your internat, wm will arrange :9 have swab a vtaa available aither
in Prague or in

any consulaec

in

West letmany,

Anstria, Vranca, ate.

,;

You

v-1;

VFW“,

Wkly-1.:

~

aheuld know thnt Dru. Reubtcnk and Valavka have 1ndieate¢

their desite to jcin us.
I! this 13 of me relcvnncc, or not feasible. I 3:111 look

forward ea working with you on tha Progt¢m Conutttoa cf the CINP.
My

bust regards.
Sincerely yaura.

ml

Fink. pm.
m
rtofosoor of Psychiatry

�</text>
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                    <text>.

.

”WWW—1n:.14“

3-

.

.

x“...

v“.

.7.-_-

gr

15‘!!4r,.—~'€K"m‘mu.

‘4.“ hbl‘l-rm‘

..&lt;H..~.-w-.----~

.v'u-r ..

A.,--1-,-«v-.-

w

xW

'w’mwn-wn. .~I—'

September 24, 1968
U. 3. Government

Printing Office

Washington, D.C.
Gentlemen:

like to order

a copy of "A Manual of Standardized
Terminology, Techniques and Scoring System for Sleep Stages of
Human Subjects" as prepared by Rechtochaffen and Kales. would
you please indicate the price or free for distribution, may we
have a copy?
We

would

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mfzkp

‘

v

~;..

,,

r.

.4.‘

--.

�</text>
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                    <text>September 24, 1968
Mrs. Pat Whiter

Bibliographic Unit
Brain Information Service
Biomedical Library
UCLA Center for the Health Sciences
Loo Angelea,

California

90025

Dear Mrs. Walter:
For many years I have compiled citations concerning the
effects of psychoactive drugs on tho EEG. For this reason,
I am particularly interested in the bibliographies which

were

listed as ready for distribution:

Effect of alcohol on the

EEG

(to 1967)

Effects of Flaxedil on Electrical Brain Activity

(1963—68)

Effects of halothane on electrical brain activity (1963068)
are interested in the manual of standardized
terminology for dhep stages of human subjects. Is this available
In addition,

we

through your office?
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Soptonbor 23. 1968
Dr. Olrioh Vinor

Psychiatric

Roooorch

Instituto

Progoo. Crochoolovokio
Dear Dr. Vinar,

Soon rook: ago I vroto regarding the forthcoming meeting
of tho CIR? program oomnittoo, roquonting a change of data. Since
than, the ovnto in Progoo on reported hora have becoao more complex,
ond on are onto that you are prooocupiod by thou: events more than
the CINE. Knowing thot Dr. Itil planned to be at tho H30 meeting
to which you have boon invitod, I on taking tho liborty of sending
this lottor with him and enclosing anothor for Dr. Vojtoohovoky. I

would be

grateful

if

you would

deliver

it

to

him

privately.

Vb Ito aware thot tho present.politicol situation may
impede your orogrooo‘in your loborotorioo. Ho have diocuoood this
problon at longth hero, and wo ore proporod to offer you an
opportunity to continua your studio. born. I! you with to join us
in How York (or wish to join another laboratory in tho v.5.) wo
will file the nocoooory forms to permit you to enter this country.
At the prooont ting, the Btote Department is cooperativo and will

not: visas for ooiootific workers available with

minimum

delay

(2-3 nooks) under tho USP-66 oxahongo otudont/tooching programs.
If you will urito, or indicate to Dr. Itil that such a atop is
in your intoroot, wo will arrange to hurt ouch a visa available oithor
in Prozac or in any consulate in What Iotaony. Austria, Franco. otc.
You

should know that Dru. Roubicok and Volovko hovo indicatod

their dooiro to join us.
If this is of no rolovonoo, or not foooiblo, I

still look
forward to working with you on tho Program Committee of the CINP.
My

boot rogurdo.

sincoroly yours.

ml

no: Fink. M.D.
Professor of Foychiotry

�</text>
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                    <text>September 22, 1968
,

Dr. Ennial Efron
Ed~1n~0hief, ?sychopbarnacology
Ravinw of Frogresa
ﬁbuhtngton, n.c.
Dear Dan.

Enclosed are the gallay proofs at two cf the three
reports which I submitted {or the ’Reviaw'. Theta are a faw ccmannts
that warraut your attention.
1.

EEG

Classification cf ?sy¢hoact1ve

Compounds.

In

this report, tbs only yrcblcn may be the title. ”Raviaw and Theory of
Behavioral Aﬁnociations“ is a submtﬁtle. ané ghould be reset.
2. EEG and Human Psychophurmncology: Clinicnl Antidepressants.
ﬂhnrc are the figuras and the legends ? These must bu included
and I would raquost anather galley proof when these arc submitted.
work of

I

would Ilka to add a few lxnel at aredit for the
and would be gratafui if yen would permit it.

this etudy

3. Rautophyaloloxy of the Phantastica. This

third taper:
available.

My

and

is the

I anticipate racciving the gallay proof

when

best regards.
Sincernly yours,

ml

th Fink, M.D.

�</text>
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                    <text>September 21, 1968

Dr. William Thbor

A.H. Robins, Go.
1&amp;0? Cummings Drive

Richmond, Va. 23220

Door 8111,

Separotoly. I have cont you the data collected in tho
liquid vohiclo. You will find the commotion
for each case, the original case data report. laboratory data bound
together, and the NINE data analyses and cord output. Dr. Clot.
and Dr. Simeon have completed a roport of their findings nod this
is now halo; typed. It will bo sent to you for your comments within

Ropoloo study using the

a week.

I

no

particularty interacted in your

comment: ooocorning

the laboratory data output. You know that this rooulto from programs
written here uoing the HIP laboratory scale. Slooo than. on hovo
cooplotod o review of out oxpotionooo and improvod tho data oolloctlon
form 80 that tho drug data will also appear on the final reports.
Copies of those will be coat to you separately. (stunt we hovo
used tho butaperazino material on our working model, I will take
the liberty of sending sample page; from thooo laboratory reports
to the ECDEU lovootigatoto. I truot you hoot no objection.)
Also, I wont to thank you for tho referral of Dr. Clark.
ouggootion that we unaortake a study of the long term offocto
of toofluramino lo a good one nod I will explore this further. I
will send him a protocol on AHR~1900 this nook.

at:

My

boot regards.

sincerely yours.
Max

ml

fink,

N.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="102674">
                    <text>September 20, l968
Mr. Gio Hiederhold

Director,

Computer

Facility

Stanford Medical Center
Palo Alto, California
Dear Mr. Hiederhold:

to thank you for making so much of your time
available to me during my recent visit. I was impressed
that you have done much for the medical school and see
I want

this as

a model

for future medical centers.

The director of our center, Dr. Donald H. Shapiro,
and I would be pleased to have you visit the next time
you are in New York.

Again,

my

thanks for your courtesy.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>.W’vf‘vrv-.t

you in

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September 20, l968

mp,“

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c

yaw—“WWVO

ywrrnvI-mmvm

&lt;'w’&lt;;u

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mum-

California State Department of Education
Sacramento. California
Gentlemen:
He would appreciate a copy of your publication “Drug
Abuse Service Book and Guide for Teachers" by Kitzinger
and Hill. This report was described at the recent western

Institute of

Drug Problems.

Sincerely yours,

«rm-,z-mnuv

av:

1
-

Fink, ”.9.
Professor of Psychiatry

Max

MF:

lip

�</text>
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                    <text>me—rr

September 20, l968
Dr. Wayne Jostrand
IBM Corp.
475 Northern Blvd.
Great Neck, New York
Dear Wayne,

to thank you for arranging for my visit to the
Center in Palo Alto. Rich Hunaate was a very co-

I want
ACME

operative guide. I was able to discuss the report briefly
at the Computer Committee yesterday and perhaps. in the not
to distant future, will be looking to expand our core.
for

When

me.

next you write to Mr. Hungate, please thank him

Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

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                    <text>‘

F“J-IvIK‘,"

«&lt;1

up

win—H

.wv-v'vptwu-r-n

v"

.r um“.

.

“.25' 151-- “in -~

w

—~.~~v-n7m-rw~-u

mum-.‘rm, . .wwvm-w~m~am

A~&gt;~r~m1~vwmma‘

-

urns—u

”m.wrvawr.l—F»mﬁ mumV‘WEV-wra-NIJVU1W

«an

napalm»: w. ...

-

«n-

Vex-m7

.w

v.

—n

September 20, 1958
Dr. Joyce 6. Small
13l5 Nest Tenth Street
Indianapolis. Indiana 46207
Dear Joyce.

It

was a pleasure discussing the electroshock program
I have reviewed six sets of records of unilateral

with you.

and find no bursts and only small degrees of background
slowing. These records are distinctly different for the
number of seizures from a similar group of bilateral cases.
ECT

When

you have a

appreciate
When

a copy.

next you

draft of your report,

visit

will be coming for the
to arrange to have you

New

York

City.

I would,

and I

of course,

anticipate

you

in early December, I would like
visit and go over some of our records
together. When we have had more experience, I would like to
arrange for one of my staff to visit you and to see the similarities
and differences. if any, in our treatment procedures.
ARNMD

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

Mszn

"z"- :-

»

-.- .,

,—

l'r

,:

w

'v

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                    <text>September 20, 1968
Dr. John Knott

Department of Psychiatry
University of Iowa

State Psychopathic Hospital
500 Newton Road
Iowa City, Iowa 5224l

Dear John,

Enclosed are two reports of the EEG effects of psychoactive
drugs. One was prepared for the Annual Review of Pharmacology
(l969) and one is a summary of the presentation at the 1967
Denver meeting of the American EEG Society.
I will try to summarize the best parts of the material for
technicians and send it to you shortly.

Thank you

for your interest.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

ox

�</text>
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                    <text>September 18, 1968
Dr. Lester

M.

Morrison

Institute for Arteriosclerosis Research

9331 venice Blvd.

Culver City, California 90230

Dear Dr. MOrrison:
Thank you very much

for your kind remarks regarding our

studies of fluphenazine decanoate. You will be pleased to
that we have just completed another study comparing
fluphenazine decanoate and the commercially available fluphenazine
enanthate. The differences between the two compounds are small
and they are sufficiently similar for the enanthato to replace

know

the decanoate.

sure that the physicians at the U.C.L.A. Medical
of fluphenazine enanthate and would be in a
make
the appropriate decioion on behalf of your
position to

I

am

Center know

patient.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>September 17, 1968
Dr. John A. Scigliano

Executive Secretary
ad hoc Merihuane Advisory Committee

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:

In support of our application for supplies of tetrahydrecannabinol and marijuana, enclosed please find the
original of the letter from the Internal Revenue Service
dated September 12, 1968 confirming the official nature
of our special Tex Stamp number 405087 and Registration 127M.
As indicated in your letter of August 23, this letter from
the District Director will serve as an order form for marijuana.

Sincerely yours,

Professor of Psychiatry
Mszp
enc o

�</text>
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                    <text>September 17, 1968
Dr. William R. Tabor

Robins Company

A. H.

1407 Cummings Drive
Richmond, Virginia 23220

Dear 3111,

I

am

pleased that the fenfluramine material was acceptable.

for being so helpful but it was not necessary
secretary to St. Louis, as Dr. Itil accomplished his
part with his staff. There are no additional expenses.
Thank you

to send

my

Sincerely yours,
Fink, M.D.
th
Professor of Psychiatry
MF:kp

cur-

:vvnvr-

wp

,

�</text>
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            <elementTextContainer>
              <elementText elementTextId="35632">
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                    <text>September 17, 1968
Dr. Edgar Grunwaldt
Geigy Pharmaceuticals
Ardsley, New York 10502
Dear Dr. Grunwaldt:
Thank you for the ketimipremine placebo. You may recall
patients
that you asked that we discontinue ketimipramine in for
longer
medication
the
been
on
who have done well and have
ketimipramine
on
each
one
have
put
than eight weeks. To do so, we
placebo first and only those who do badly will receive imipramine.
The new

at the

end of

protocol should be

amended

eight weeks.

to give ketimipramine

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

max
MF:kp

p lacebo

�</text>
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            <elementTextContainer>
              <elementText elementTextId="35642">
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              <elementText elementTextId="35643">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102681">
                    <text>September 9, 1968
Dr. Norman

Chas

Pfizer

Pitts
&amp;

Co.

Groton, Uonnecticut
Dear Norm,

I look forward to your visit sometime in the next
few weeks. We are actively involved in the EEG study
and I will request a review of the ongoing DoxepinChlordiazepoxide study so that I may have some data when
you come.

In the meantime, would you please send us an
additional supply of doxepin ? The present labels read,
"Sinequan, 25 mg.."l00 caps/ bottle, (white and black
capasules).
Would you
Many

arrange to send lelOO

?

thanks.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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              <elementText elementTextId="35651">
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            <elementTextContainer>
              <elementText elementTextId="35652">
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              <elementText elementTextId="90889">
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                  <elementText elementTextId="102682">
                    <text>Beptcnbcr 6, 1968
Dr. Jamea Mcrknl
squibb Pharmaceutical;
Riv Jeraay
‘Dear Dr. Hhrkol,

ﬁbula you pleas: make availabla an additional aupply

of 10 viala of ﬁluahenazina enanthata for tha continuatian
Wk still have
of our final graupo a! subjuata 7
tau. vials
but thay has: an expiratien data of October 1, 1968. abut it
the heat mtg? with thia remainder 1 In it still to ba uned 7
The data of an: arossaver study is new complete and um
have the case records and the report available for 40 subject.
who camplntad the crossover and 68 who participated. Th:
final copias ara in the typist's hands and should ranch you

shortly.

Thank you. one: again.

for your cooperation.
Sincarely yours.
Fink, M.D.
Professor of Psychiatry

M3:

MF/

�</text>
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                <text>Correspondence to: Merkel, James R.</text>
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                    <text>September 6, 1968
Dr. Ed Grnnuwald
Goigy Pharmaceutical:
Ardsloy, New York
Dear 8d.

Attacbad is a tear—aft labs! from the uvntlable aupply
of placcbo for knttmipramina. ﬁbuld it be possible to make
an additional 243106 capsule: for thlo study ?
Wt

have couplatad aha data analysis of the laboratory

on the first kettm1pram1nc stuay. and
within
to
a few dxya *» I an awaiting eons
you
it
xarax copies of the lab ﬁata to make thé package complete.
and tha

HIMH

I will send
My

material

bets regards.
sincarely years.

Fink, E.D,
Professor of Psychiatry
Max
MF/

�</text>
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                    <text>September 6, 1968
Dr. Joeeph 31rd

Sterling Winthrop Institute

Reneeeleot,

New

York

Dear Joe:

I completed the report: of oycleeocine en en
cop} to Dr. Nathan Kline. He has expreeeed
the study. I know of no one in the ECDEU programs
when

entidepreeeent. I pent e

an

intereet

1n

who he: as good a record on he bee, in defining oer compounds. and
may be most useful for you to have him look at oyoleeooioe.

it

Inoideotelly. I have enquired about Tolwin in our community
and no one has been reported abusing this compound in our population.
Some of the etetf thought the: vo ohould look among the Village
population tether than the Harlem scene. A: upon ee my staff returns
from the summer exodus, I will discuss the ptogten with them.
My

bent regards.

sincerely yours,

Mix

Fink.

HOD.

�</text>
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                    <text>7.
[-9
2.

I
5

E

September 4, 1968

§

2

g
a

anagrams?

'
ma"

n—‘uaro

Dr. Harold Meiselas

Associate Commissioner

Treatment and Rehabilitation
Narcotic Addiction Control Commission
l855 Broadway
New York. New York l0023
Dear Dr. Meiselas:
The study program supported by the

New

York

State Narcotic

Control Commission, is focussed on the continuing evaiuation of
the psychopharmacological - rehabilitation treatment model. During
l967, emphasis was placed on an evaluation of dosage range.
tolerance and secondary effects of cyclazocine. naloxone and
tybamate; the role of heroin challenges in the evaluation of
dosage and of treatment; and in establishing a comparison of
methadone and cyclazocine. In addition with USPHS support, we
have evaluated cyclazocine as a clinical antidepressant;
determined its EEG profile in rabbits; and determined the EEG
profile of heroin, cyclazocine, methadone, naloxone and their
‘

.

‘

n-u-m

interactions.

raw-"rmwm,

I'mr‘azu-Pw,

E

E

Copies of reports completed in l967 and to July 1968 are
enclosed, as providing the best summaries available.
These studies are continuing and the present schedule
includes the evaluation of methadone changes in EEG; methadoneheroin interactions; continued evaluation of cyclazocine-methadone;
and a clinical evaluation of naloxone.

a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr.

Mr.

A. M. Freedman
I. B. Schwartz

�August 1968

STUDIES IN OPIATE DEPENDENCE

1967-68

Cyciazocine and Methadone in Narcotic Addiction.
202: 191-194, 1967.

JAMA,

Ciinicai Studies of Cyciazocine in Narcotic Addiction.

J. Pagehiat.,

Amen.
EEG

Effects

of Cyciazocine.

124: 1499-1504, 1968.

Narcotic Antagonist

A

In Koeiia. N. and A. Karczmar (Eds.), Paoceedinga
05

the

ACNP,

1966.

C.

C

Thomas,

Springfield. (in press)

Antagonists in the Treatment of Opiate Dependence.
In Phiiiipson. R.

V.

(Ed.),

Nodenn Taenda

in

Cbmbatting Deng Dependence and Azcoholiam.

Butterworth, London.

(in press)

Intravenous Diacetylmorphine (Heroin) in Studies of Opiate
Dependence.

OLA. Menu.

Naloxone in Opiate Dependence.

Sya.

(in press)

Olin. Phanmacoz. Theaap.

Ciinicai Triai of Cyclazocine in Depression.
Amen.

(in press)

Submitted to

J. Paychzat.

Neuropharmacoiogicai Analysis of Agonistic Actions of Cyciazocine

in Rabbits. Presented at the Soc. 8101. Psychiat., June 1968.
Tybamate in the Treatment of Opiate Dependence.

12-21-67).

(Preiiminary Report -

�</text>
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                    <text>September 20, 1968
Mr. 610 Wiederhold

Director,

Computer

Facility

Stanford Medical Center
Palo Alto, California
Dear Mr. Hiederhold:

I want to thank you for making so much of your time
available to me during my recent visit. I was impressed
that you have done much for the medical school and see
this as a model for future medical centers.

The director of our center, Dr. Donald M. Shapiro.
and I would be pleased to have you visit the next time
you are in New York.

Again,

my

thanks for your courtesy.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>September 20, 1968

California State Department of Education
Sacramento, California
Gentlemen:
We would appreciate a copy of your publication "Drug
Abuse Service Book and Guide for Teachers" by Kitzinger
and Hill. This report was described at the recent Western

Institute of

Drug Problems.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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                  <elementText elementTextId="105708">
                    <text>September 20, 1968
Dr. Joyce G. Sma11

1315 West Tenth

Street

Indianapo1is, Indiana 46207

Dear Joyce.

It

was a p1easure discussing the e1ectroshock program
I have reviewed six sets of records of uniiaterai
ECT and find no bursts and oniy sma11 degrees of background

with you.

These records are

slowing.

distinctiy different for the

number of seizures from a simi1ar group of bi1atera1 cases.
When

you have a

appreciate
When

a copy.

next you

draft of your report,

visit

for the

New

York

City,

I would,

and I

of course,

anticipate

you

in early December, I wouid iike
to arrange to have you visit and go over some of our records
together. When we have had more experience, I wouid 1ike to
arrange for one of my staff to visit you and to see the simiiarities
and differences, if any, in our treatment procedures.

wi11 be coming

ARNMD

Sincereiy yours,
Max

Fink,

M.D.

Professor of Psychiatry

MFrkD

�</text>
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                    <text>,.

,1.”

vumwvmwv‘m‘-

September 20, 1968
Dr. John Knott

Department of Psychiatry

University of

500 Newton Road
Iowa City. Iowa 52241

Dear John,

Enciosed are two reports of the EEG effects of psychoactive
drugs. One was prepared for the Annuai Review of Pharmacology
(1969) and one is a summary of the presentation at the 1967
Denver meeting of the American EEG Society.
I

'1!

wiii try to

summarize the best parts of the material
it to you shortiy.

technicians and send
Thank you

for your interest.
Sincereiy yours,
Max

MF:kp

u»

1W

guy—p

r'u

-

wusznmrwnmnm~w

V

Fink, M.D.

Professor of Psychiatry

-v~rn}'w

Wye-a.

Iowa

State Psychopathic Hospitai

DL‘

for

�</text>
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                    <text>September 18, 1968
Dr. Lester

M.

Morrison

Institute for Arteriosclerosis Research

9331 Venice Blvd.

Culver City, California 90230
Dear Dr. Mbrrison:
Thank you very much for your kind remarks regarding our
studies of fluphenazine decanoate. You will be pleased to
know that we have just completed another study comparing
fluphenazine decanoate and the commercially available fluphenazine
ensnthate. The differences between the two compounds are small
and they are sufficiently similar for the enanthate to replace

the decanoete.

I am sure that the physicians at the U.C.L.A. Medical
Center know of fluphenazine enanthate and would be in a
position to make the appropriate decision on behalf of your

patient.

Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Septembor 6, 1968

Dr. James Lowry

Director, Dopsrtusnt of Mental
1500 Fifth street
Sscrsnsnto, California 95816

Hygiene

Dear Dr. Lovry,

repott presented at the Hostsrn Institute was
st our study units and presented
in various papers. ooms published sod some in press. The
most recsnt sunosry is that prepared for Dr. Phillipson's
The

a synthesis of dsts collectad
volums on drug dependence.

entitled "Antagonists in the

Treatment of Opiate Dspsndsnce“.

Additional reports are enclosed as background material.
Thank you

rsvidw of the

for your interest

LSD

and for tho excellent
and hallucinogenic problsns in California.

Sincerely yours,

v
«A

,

Pink, M.D.
Professor at Psychiatry

Max

v.
.4

”—2,;-

.v'v’

V'Wv‘ltw‘”.-qw:m"ﬁlw;nvrrvyz'JVa*-'

w

v,»

ml

�</text>
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                    <text>”.1

,‘

”gnaw“.

..m..4

Saptcnber 6, 1968

M»,-

1

(no:

Lamar—r1,

Dear Murray,
Tha menbcrship committee chairman, A1 Frcadnan. has
asked that we supply him with an accurate count of the
membership, no that he can plan for the additional members

to be invited.

that your

-

list

Hy lists are not up to dntc, and I believe
in probably the bent.

-:-w—:.W~a&lt;

-'r‘h'«‘L

mm“:

wnuwv-vwar-w

ﬁbula you ask your sacrotnry to make a count of the
members, less the honorary and other spacial categories,
and lat me know ?
Many

thanks.

u
:r
02/-

UV

A

Sincerely yours.
Max

Fink, Md).

�</text>
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                    <text>September 4, l968
Dr. F. Hoffmeister
Institute of Pharmacology
Farbenfabriken Bayer A.G.

Wuppertal-Elberfeld
West Germany

Dear Dr. Hoffmeister:

During the CINP meetings we discussed our common interest
in anticholinergic drugs. Cyclazocine is an active narcotic
antagonist, whose EEG profile is similar to that of imipramine.
From this observation we decided to measure its antidepressant
activity. The summaries of our two studies are enclosed.
We

and I am pleased that we have
clinical supply for studies that

also discussed naloxone

been able to obtain another

are now in progress in the treatment of opiate addiction. Of
course, we are interested in other narcotic antagonists, especially
those with a duration of action longer than naloxone.

trust that you will have
your next trip to New York.
I

on

an opportunity to

visit

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

us

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                    <text>,v

"gr-w

m

np—~

—

m

raw—me

September 4, 1968
Dr. F. Hoffmeister
Institute of Pharmacology

Farbenfabriken Bayer
Huppertal-Elberfeld

A.G.

West Germany

Dear Dr. Hoffmeister:

meetings we discussed our common interest
in anticholinergic drugs. Cyclazocine is an active narcotic
antagonist. whose EEG profile is similar to that of imipramine.
From this observation we decided to measure its antidepressant
activity. The summaries of our two studies are enclosed.
During the

CINP

also discussed naloxone and I am pleased that we have
been able to obtain another clinical supply for studies that
are now in progress in the treatment of opiate addiction. Of
course. we are interested in other narcotic antagonists, especially
We

those with a duration of action longer than naloxone.
I

trust that

on your next

you will have an opportunity to
New York.

trip to

visit

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

us

�</text>
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                    <text>September 3, 1968

Jaffe

Dr. Jerome

Department of Psychiatry

University of Chicago School of Medicine

Chicago,
Dear

Illinois

Jerry,

After reading your reports and hearing your presentation
in Portland, I am impressed that methadone maintenance provides
an effective model. Especially, when presented in the storefront approach. As I mentioned, our rehabilitation staff have
been encouraging us to undertake such a community - based
operation. Your presentation convinced me and I have written
a memorandum to Al suggesting we examine such a program seriously.

possibility of studies of

acting methadone
to participate in the
To carry out such a
with
we
Paul.
of
discussed
study
type
IND
and eliciting the
of
the
an
project may require
filing
of
manufacturer
the
for
continuing supplies. I
support
would be pleased to help in any way that I can.
The

is impressive

:.—mmnwzrw—V

Good

a long

and I would be pleased

luck in your program.

My

best regards.

rr'

Sincerely yours.

‘mWa

:4”-

1-:

FW‘FJ’V

Max

Fink,

M.D.

'

Professor of Psychiatry

MFtkp

,

‘WCW'V’W‘NWXDH

�</text>
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                    <text>September 3. l968
Dr. Alfred

M.

Freedman, M.D.

Department of Psychiatry

York Medical College
East l02nd Street
New York, New York l0024
New

ma

"hum

W!

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,

um

'«I'Wg'

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5

Dear Al,
Thank you for your kind invitation to participate in the
Second Edition of the "Comprehensive Textbook of Psychiatry".
The widespread acceptance of the First Edition assures its

continued success.

It will

be a pleasure to participate again, and I will be
to
provide the section of "computers and psychiatry".
pleased
As you know, I am a protagonist of a more general application
of EEG to psychiatry and perhaps you could consider the inclusion
of some of the recent reviews in either the sections of EEG or
of psychopharmacology.

Sincerely yours,

;
rs

n

Fink, M.D.
Professor of Psychiatry

Max

&lt;165ryﬂ';7llvv

W”

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�</text>
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                    <text>September 3, 1968
Dr. William Guy

ECDEU Coordinator for Data Analyses
The George Washington University

Biometric Laboratory
Washington, D.C. 20036
Dear

Bill,

to thank you for the data analyses of our two
studies. butaperazine and ketimipramine. These have been
most helpful and I believe that these results. as I have
presented them to the staff will assure their greater
cooperation in future projects.
I want

Enclosed are data outputs from our present laboratory
data forms. You will note that there are three types of
output - a reading of the optical scan report; a summary
by patient giving a portrayal in time of each of the
laboratory reports; and a summary for each laboratory test
of all the reports in that study.
The data form used in these analyses did not have room
for the drug, dose or route and these have had to be added
by keypunching. Also, the forms develOped in Missouri have
many items which do not come from the clinical laboratory.
As a result, we have created a new fbrm which corrects many

of these apparent deficits.

If

Copies are enclosed.

such a form could be used, and especially if various
be encouraged to carry out laboratory analyses
could
centers
in patients not receiving novel psychoactive drugs but either
placebo, no drug or accepted FDA approved compounds, then we
can develop a set of laboratory standards both for individual
laboratories and for the ECDEU program as a whole. Such
standards would be most useful in answering the questions
of the FDA and of industry with regard to the significance
of "abnormal” laboratory findings.

�-2-

Dr. Guy

September 3, 1968

I shouid iike to make a report of the 01d iaboratory form,
the data outputs, and the new form avaiiabie to members of ECDEU.
Before doing so, I would like to discuss this with you, Dr. Saizman
and/or Dr. Levine - whichever you recommend.

Again,

my

thanks for your heipfui anaiyses.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
ENC .

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                    <text>.ﬁwnv—nwvw

,,

ry-w—

«n

0:7,":

--~

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“”me

WV. "thaw.“

s.7_

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,. .,,.-g.svwr~-.—v-

September 3, l968

Jaffe

Dr. Jerome

Department of Psychiatry

University of Chicago School of Medicine

Illinois

Chicago.
Dear

Jerry,

After reading your reports and hearing your presentation
in Portland, I am impressed that methadone maintenance provides
an effective model. Especially, when presented in the storefront approach. As I mentioned, our rehabilitation staff have
been encouraging us to undertake such a community ~ based

operation.

Your

a memorandum

The

to

and I have written
suggesting we examine such a program seriously.

presentation convinced

Al

possibility of studies of

is impressive

type of study

me

acting methadone
to participate in the

a long

and I would be pleased

we discussed with Paul. To carry out such a
require the filing of an IND and eliciting the
support of the manufacturer for continuing supplies. I
would be pleased to help in any way that I can.

project

may

Good

luck in your program.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

.

-

w-wn

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                    <text>September 3, l968
Dr. Hilliam A. Frosch
New York University Medical Center
550 First Avenue
New York, New York l00l6
Dear Dr. Frosch:
from Professor Votava may have been a bit
premature, for in his enthusiasm, I believe he did not wait
for the forthcoming meeting of the Program Committee of the
GIMP.
I do not know how to answer your request except to
tell you that the CINP holds open meetings every two years.

letter

The

All participants provide for

their

own

expenses with the

occasionallexception of special invited lecturers whose
expenses may be deferred by the Program Committee, if, and
only if funds for such a lectureship are made available by
private donors.

_

The Program Committee will be meeting in the Spring of
l969 in Prague. I plan to attend and as soon as I return
should be possible to answer questions regarding the need
for abstracts, length of paper, egg, Accommodations and other
details of the meeting itself will be sent to members of the
GIMP and to all participants late in 1969.
It is also our
intention to plan a charter flight and details regarding this
will be sent to you at the same time.

it

That

is. if the

the climate in this
My

Russians permit such a meeting, and
country has not changed.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

if

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                    <text>September 3, l968
Dr. John A. Scigliano

Executive Secretary

ad hoc Marihuana Advisory Committee
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:

Separately, I am answering your letter of August 23,
regarding the additional information requested by the
Advisory Committee which met in July l968. I trust that
these answers will satisfy your interest.
have a list of the present ad hoc Marihuana
Committee?
Advisory
May I

Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ko

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                    <text>September 3 , 1968
Dr. John A. Scigliano

Mecutive Secretary

ad hoe Marimana Advisory Camittee

National Institute of Mental Health
Wisconsin Avenue
Chevy Cruse, Maryland 20203
51450.

Dear Dr. Scigliano:

for your letter of August 23 referring to the
Advisory Cannittee meeting of July, deferring my request for
legal supplies of marijuana and me for research, pending
answers to questions raised by the Committee.
Thank you

The following

are the answers requested.

First , let me imiioate that the BEG-behavioral studies of
any new drug are complex and while some analyses can be accomplished
with few trials, most require many experiments. The number of
trials (and the mnnber of subjects) are "as many as necessary".
For example, the recent analyses of fenﬂmemine required twenty
subjects only. For heroin, however, we have completed mm than
one-hundred and fifty trials in mre than seventy subjects and
methadone we now have mre than eighty
still areinunsatisfied. Forand
probably have enough for a preliminm'y
subjects
twenty
record:
analys 5.
additional problem is the rwte of ministration. We have
limited experience with drugs given by inhalation. I anticipate
that we will make many errors initially. For this reason the answers
to the questions below are approximate.
(I) How many subjects me you planning to use?
An

,

sw/W-znanz'nm'rz

Wﬂm.-lﬂﬁ"5‘7AY¢3meﬂNm79'r-T\VNY'

run:

mains-1

raw

:‘Wx‘v

(a)

POM-addicts?

(b)

Momma?

(a)

20—30,

(b)

6

-

12

fewer,

How
How

’

if

repeated

many?
many?

trials are satisfactory.

�-2-

Dr. Scigliano

(2)

September 3, 1968

Dosage
(a) Dosage to each?
(b) How my doses?

(a) Dosage to each?
1. Tm: 20 mg initially. This dose will
be increased as needed until either EEG
or behavioral effects , or both are
clearly manifest.
2.

(b)

How many

1.

2.
(3)
g
s
E

Marijuana:

'IWo

"puffs" increasing to a

full cigarette or nultiple cigarettes ,
as wmnted.

doses?

at least two trials per subject,
If the dose response
becomes of interest , probably three to
five doses for each subjects.

THC:
THC

Same

and a blank.

as

THC.

subjects to be scanned psyche/tummy
(a) Post addicts: a psychiatric examination is recozded
in each subject. Those with complicating diagnoses ,

How

Me

«the

as depressive psychosis , schizophrenia or chronic
alcoholism are excluded.

E

E
E

E

Q

(b)

E

Volunteers: Each volunteer undergoes a psychiatric
examination and evidence of psychosis is sufficient

reason for exclusion. In addition, we plan to
include only those volunteers who admit to previous
marijuana exposure in these studies. Each volunteer
also completes the MW]: which we are not investmating
as a screening device.
(4)

whet

mama will be taken to pleated: the normal vomnxeu?
present study progmm with normal volunteers provides
the basis for the trials with marijuana and THC. The
project is frankly eXplained to each suhﬁect by a
research assistant and then again at the end of the
psychiatric interview, by one of the senior scientists.
At the end of this explanation the subject is asked to
sign a permit for a research study.
The

�-3-

Dr. Scigliam

Septenber 3, 1968

After each exposure, subjects are advised
to undertake only limited activities for a
minimnn 2n hour period. We do not permit

thentodriveaoarardpayalltaxiexpenses
home
member
and all subjects
is monitored by a staff
areaskedtoretumtothe 2Hlaboratoryortobe

to and from the laboratory. Their return
visited by a staff umber

hours

after exposure.

In the event of an untoward reaction, admission

to the Psychophamacology Research

Metropolitan Hospital

Ward

of

is assured, or for

females

the private pavilion of Flower and Fifth Avenue
Hospitals is available. The principal investigator

is

m

W'v-

-.

(5)

(Um-v

psychiatrist at both institutions.
CW” 5M. the heaoin challenge studied - the due
and whethu M4119 poet-addicts and/on newt voluntew.
Heroin challenges have only been done, so far, in
post-addicts. Our usual dose is 15 - 30 mg/ch
saline/ 2 minutes intravermsly. When heroin is

Yty'rI-‘Q'Wﬂmrr’vn'x

given to subjects who are not receiving duonic
narcotic antﬁonists , we administer intravenous
naloxone (1 mg) at the end of the eaqaeriment and
give oral naloxone (2 mg) approximately 3 hours
after heroin exposure.

F,¢n-.¢u~v.—

Man-w,

..

.—

n

sea-.1

V’a-zr'"

Viva“

:v

xy-nvawvv

an attemling

(6)

a
$221be
heat £a

ace

«:0qu be

~

the dwge - both mau’juana and A9-THC
ue compounds and the passe/med Manage
l8'CC. Secwxg Ahoutd be mntained by

inch and hey.

.r:

:

&lt;t1wemvvrwmr¢smmmrmwwrr

wa'rv

,

'er-r‘

W‘s,-

Stability of the drugs: yes .

�a.

Dr. Scigliano

(7)

September 3, 1968

-l&amp;-

0554mm! owe/L 5mm: -

etc.

Letter requested (see xerox enclosed)

Sinceme yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkp

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                    <text>September 3 , 1968
Mr. Edward

J. Fitzgerald, Jr.

120 Chm-ch

Street

District Director of Internal

New

York,

New

Revenue

York

Dear Mr. Fitzgerald:

are anxious to undertake studies of mrijuma and have
previously filed for a narijuana tax receipt. We have received
this and a copy is enclosed.
We

In attempting to follow existing regulations, we have filed
the National Institute of Mental Health BREW, the necessary
application forms for marijuana and TH). The Executive Secretary
of the ad hoc Marijuana Advisory Conmittee, Dr. John A. Scigliano
has mitten to us on August 23 requesting that we obtain an official
order form. A xerox copy of his request to us is also enclosed.
With

Followm his request,

letter which comments

would you kindly

our licensing in Class

furnish us with a
V

for marijuana?

In the event that this letter is addressed to the wrong
authority, wcmld you be so kind as to call me directly at
(212) 369-7900 Ext. 2% and advise me as to the proper office
to which this request should be directed.
Thank you

for your cooperation.
Sincerely yours ,
Fink, Md).
Professor of Psychiatry

Max

MF:]-:p

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                    <text>September 3 , 1968

Jiri waicek
Prague 8 - Bchnice

Dr.

Psychiatric Research Institute
Czechoslovakia

Dear Dr. Roubicek:

return from holidays , I found your kind letter of
the reprints describing your origiml studies of
convulsive therapy. Two reports in particular are most interesting the studies of the pathway of electrical current and the EEG changes.

July

On my

30 and

We

are comparing the clinical

and EG

effects of unilateral

bilateral convulsive therapy. That the memory
in these two treatments is well knovm, with bilateral
differ
patterns
ECT inducing, nore memory changes than unilateral. But the EEG patterns
are poorly described. We find the sauna changes with bilateral reported
by yourself and many others - high voltage delta and theta activity ,
bilaterally. With convulsions induced by a unilateral placement of
convulsive with

chzmges are much less pruninant with a decrease in
and asymmetry as the most cannon.
synchronization
voltages , poor
The bilateral slow waves of grand mal ECT are missing. Perhaps you
can recall from your old experiments an answer to the question of

electrodes , the

what the differences in pathways would be for seizures induced

unilateral placenent of electrodes ,

when compared

iter

to seizures induced

after bilateral placenent?
I could only read the Ehglish smmry of your study of

EEG

and

electroshock? That you did not find the same as Roth (or ourselves)
is unfortunate and may probably be a function of the time or the
techniques of III-)3 analysis.

have been much troubled by the stories in our newspapers
new in progress in Prague. I hope that these do
not interfere with your plans. You know that we will do whatever
we can to assist you, or other members of the psychophannacolcgy
society in continuing your studies under the Host optimal conditions.
We

of the changes

�-2-

Dr. Roubicek

September 3, 1968

It may be of some help to know that Professor Turan Itil, a close
associate in our research programs will be attending the forthcoming
WHO Meeting in Yugoslavia.
I am sure that you or your associates
can discuss with him your programs of research.
Thank you

for your reprints.

Incidentally,

and Dr. Matousek.

of the work of Dr.
itamwas good to hear have
had

I

glad that they

Volavka

an opportunity to
visit the many laboratories in Europe and hope that we can hear
more of what is in progress when next we meet.
My

best regards to you, your family and your fine associates.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Septanber
Dr. 0. Vinar and
Dr. Z. Votava
Psychiatric Research
Prague 8 - Bohnice
Czechoslovakia

3

, 1968

Institute

Dear Drs. Viner and Votava:
Thank you for your kind invitation to participate as a
number of the Program Cazmittee for the 1970 CINP Congress in
Prague. I am pleased to accept and look forward to joining
you next spring.

dates suggested, Amil 11-12 , are diffiwlt for me.
require a special trip. However, I plan to be in
It
Europe fmn May 11-16 and would find it convenient to meet
with you either on May 8-10 or early in the week of May 18.
Either of these dates would permit me to make one trip.
The
would

If these dates are not convenient , it may yet be possible
tobeinﬁuopeleteinf‘ebmaryandlmuldbeableto joina

meeting in Prague
and March 2.

at the

end

of that

month , between February 28

I hope it may yet be possible to arrange the meetings of
the Program Oomnittee at any of these , more convenient dates .
I

to suggestions for topics of synposia of the Congzees ,
listing these sepamately in the attached menorandmn.

As
am

I look forward to joining you in the spring.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

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                    <text>“my

...

September 3 , 1968
Dr. Milos Vojtechovsky
Institute of Pharmacology
Medical Faculty of Hygiene

Charles University
Pram 10 - Vinohrady, Srobarova

Czechoslovakia

50

Dear Miles ,

I have received a kind invitation from Dre. Vinar and
Votava to participate in the Program Conunittee for the 1970
meeting of the CINP in Prague. As I answered their invitation,
I was reminded of my lecture at Charles University and the many
kindnesses of the members of the Czechoslovak Psydmphammcology
Group.

I

found the discussions dwing that visit most valuable
and, as our study programs are eXpanding, we would be pleased

to

available to

you or qualified Heathers of your society
continue
Opportunities to
our discussions and participate in
om." study programs.
make

Professor Turan Itil, a close associate and a member of
the faculty of the University of Missouri , will be attending
the WHO Meeting in Yugoslavia early in October. I ism that
he would be pleased to discuss our programs with you, if the
oppm'tunity presents itself.

I have just

had the opportunity

to read Simhies little

volume "Biological Psychiatry" and was most interested to see
that he gives credit to you for many of the discussions in this
fine volmne.
My

best personal regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Septanber 3 , 1968
Dr. Jean Titeca
University of Liege

Psychiatric Clinic

11, rue de la Luzerne
Brussels 3 , Belgium
Dear Dr. Titeca:

It will be

Dongier and
a pleasure to join Professor
EEG"
at the forthcoming
yourself in the section on "Clinical
symposium on the nem'oleptiques in Liege on May ISL-16 .

I look forward to discussm the EEG changes with neuro—
leptiques and other psychoactive canpcunds , both in patients
and in normal volunteers. For the past few years we have
measured

emphasized the wide range of changes which can be
using the latest digital computer methods of EEG analysis.
This data has recently been useful in classifying the
Spectrum of psychoactive compounds and a discussion, either

of the varieties of EEG patterns that allow for the classifica~
of the
tion of psychoactive canpauﬂs or a detailed discussion
be
possible.
nemephysiology of the neuroleptics would both

for the expenses of travel , it is most difficult to
answer at this time. You may know that the principal sauce
Health
of travel funds are the research grants from the Public
March
of
Service or special funds of the university. Since
from
the
this year, foreign travel funds have been unavailable
As

Public Health Service accept under very special circumstances .
funds are
a consequence of govermtental cutbacks , university
from both
funds
also severely restricted. While I will request
make
our participation
sources in the hope that either one will
will not be
answer
the
symposium
possible,
in this important
ask that
available until next spring. For this reason, I would
made
available
the organizing caunittee inquire if funds can be

As

from Europe.

�~2-

Dr. Titeca

September 3, 1968

Separately, I am pleased to send you a copy of a review
of the nemphysiology of psychoactive compounds which I have
just completed for the 1969 volmne of the Amual Review of

Pharmacology. This should provide you and Professor Dongier
with sufficient information about recent work so that our
participation can be placed in ﬁe best context.

thanks for your kindness in considering our
in
participation this interesting symposiwn.
Again,

my

Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>September 3, 1968
Dr. ?radar1ck Clark, M.D.

ACE.

Rabm.

Richmond, Va.

‘30.

Dear Dr. Clark,
Thank you for tha informational material to: A£R~1900 and thn
enquiry regarding an EEG study of a dalayeé aetiou funﬂlurcmine.
I hava found both queantons of grape intarest and cansiderahle
challenga. and would lit: the opportunity to discuss this with
my associate:. Unfortunatsly, two are still away on holidays
and will not return for another week, and I will be away for
aama dsyn

thereafter.

I am writing to ask yaur indulgnnce 13 my daisy
in annuaring these enquiries. I will writs or nail yan ﬁuring
the third waek a! Septanbar.
Sincerely yours,

Fink, M.D.
Prefeanor of Psyahiatry

Max

'm/

�</text>
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                    <text>September 1, 1968
Dr. Francis Chinnrd
Professor and Chairman

Department of Medicine
New Jersey College of Medicine
East Orange, New Jersey‘
Dear Dr. Chinerd,
Thank you for your kind invitation. or the history
which
to
you refer, I know only that which has appeared in the
I
public press, and as I had no personal involvement with
paid little direct attention and as a consequence, know little

it,

of the

institution's history.

opportunities at the New York Medical
College are
satisfactory, and I have given no thought to
another move. Nevertheless, I would be less than candid if I said
that a leadership role in a medical center did not interest me.
The programs and

most

I am enclosing a copy of my curriculum vitae and
bibliography for your consideration.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>December- 30, 1968

Dr. William Tabor

A. H. Robins Ounpany
11407 Clmmings Drive

Fidmnnd, Virginia 23220
Dear

Bill,

RE:

Butapemzim. Syrup S’mdy

There are two patients who are receiving butapemzine
syrup and who should continue this form of treatment since
they have done well and Dr. Clare would prefer maintaining

the medication to allow mintenaxwe of the present state .
Smuaries of the two cases are attached.

An investigation of our supplies of 12/ 27 indicates that
we have 9 pints placebo and 70 pints butaperazine available .
Would you please file an mandaent to the study protocol
allow
us to continue these two patients for a minim of
to

one year. As soon as we have found other ways of treating
them we will return the renaining supplies of butaperazine.
Thank you

for your cooperation.
Sincerely yours ,
Max

Fink, Md).

Professor of Psychiatry
MF:kp

�</text>
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                    <text>monomer

30

, 1988

Ir.

Jean Titeca
University of Liege

Psyddatric Clinic

11, we do 1a Luzeme

Bmsela

3,

Belgium

Boar Dr. ‘l‘iteoa:

to moeivo the invitation of Professor Bobon
8.1.1?! . in Liege in May. As you 3mm, I
the
in
to participate
the
goal of relating EEG ﬂanges to
have actively wood

I

was pleased

ounpomwds since 1955 . Tm
was held
Hanan
and
Psycmphamyaoology
on
first symposiumWorld
members
Four
of
of
Fsydiiatry.
1961
(ingress
in
at the
S.I.1‘-i.
may
arﬂ'it
the
of
invited
tho
list
on
that pawl
be useful to bring this mmkable subject: note—date by presenting
the data of the past seven years. In that regard, I am ornloeing

behavioral (effects of psydioactive
EEG

m

as mquested by the Secretary of a presentation for the
a
The
data is atomized in sufficiently succinct form to
3.1.N.
provide the basis for a theory to be discussed. The theory of
interaction of brain fmction and behavior is rooted in other
biological momma , notably EC? and ICI‘ , but has its; best
expmssion in psychoactive dmgo , and especially in antipoyohotio
drugs.
technical features of the
In addition, them are

sum

latest analytic

of the S.I.N.

methods

m be of interest to

that

the:

may

participants

I look forward to participating in your sassions in
Sincerely yours ,
Max Firm,”
,
.

_..

M‘mp

,
«.1

.

Professor of Psyohiatx'

,
A)

"Wynn”;

rm).

cc: Dr. Bomn

May.

�</text>
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                    <text>r

Vs

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST 102ND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT OF PSYCHIATRY

December 28, 1968
Dear Jack,
~~Thank you for your letter and I am enclosing some
articles which may be of interest and some comments. First, however,

about EEG-— I have no argument with spectral analysis except its
expense for the missions which I have set for myself, i.e. the
measurement of drug induced changes. For these purposes, every study

shows an equivalence for period analytic and power spectral methods—and the period methods, when done carefully, are ever so much less
expensive. At present, I can do either easily and do use whichever

lends

itself to the

analysis. For
spectrum.

a

problem at hand. For simple drug changes, period
detailed analysis of the faster frequencies, power

This is a very difficult question for me
review of our data, and the report which
indicates that even (or especially) in shronic mentally ill we ran
a significant risk of inducing psychotic episodes; I am also
aware that in this group spontaneous psychotic episodes occur fre—
quently. Our article is enclosed, as is a review from the Canadian
Mediéhal.Association Journal. This latter is the most complete to
As

for

LSD.

to answer. Despite

my

date.

position is to tell young people that experimentation
is'always exciting and frequently useful; but also occasionally dan—
My own

gerous. That experimentation with mind—altering drugs (and I always
tell them of the EEG patterns of these drugs) is probably the most
exciting experience possible, but also one that has risks (which
are usually described) and that the best experiments are done under
conditions where control is possible, i.e., a laboratory. I have
offered some the use of the laboratory and the drugs themselves, and
have had afew takers. Another risk is the fact that the supplies on
the street are often impure and adulterated. I tell them about the
heroin supplies which we get from the FBN and which have recently
been 80% 'pure'; of the THC samples that were amphetamine and scopolamine;
and of the LSD that was scopolamine (each analysis in our laboratories).
The most difficult problem is the question of marijuana, which is
more like alcohol and less like LSD; is probably safe even in large
doses; is non—addicting in the usual sense, and surely less so than
nicotine and alcohol. Our community is psychotic about this drug,

�-2and the

irrational approach has clouded the probable real risks of

the other hallucinogens.

Perhaps the greatest approach may be to agree with the
students that their futures, if males, is indeed bleak so long as the
war continues; and that escapism is a normal approach and desire; and
that various escapes are possible—— hermits and other isolation
devices; drugs and other temporary mind—clouders; emigration; or
identification with a problem or mission in which the sense of
participation and 'being with it' may be more satisfying than any
of the withdrawal defenses. The team roles and the gratifications
have been also useful.
In answering such questions (and I have frequently) I am
not embarrassesLby the question of 'Why do you
, and tell us
that it is bad for us?'/since I have tried all the drugs and do not
use any now; and when the question of alcohol, smoking, barbiturates
or amphetamines come up—— it is easy to state that these are not
useful when other devices of adaptation suffice. The biggest question
in students is the difference between their parental or teacher's

statements and actions.
How

LSD

2

useful these approaches are will not

be known. The

kick has stopped iﬁ'New York and the incidence of admissions to

hospitals have dropped significantly. In large part, this is the
result of the (mistaken, I believe) notion that LSD is specifically
dangerous to genes. The evgidence does not convince me and I do not
use this 'scare' other than to remind the questioners that there
are many effects of drugs that we are unaware of--and tell them of
the interesting studies of thalidomide and pregnancy.

sufficient for the present. In View of
am
I
the possible additional help,
enclosing a pre-print of a study
of hallucinogens that I completed last year for the ACNP and which
‘will be in press in the spring. This describes the central effects
of two large classes of hallucinogens in man and has been useful in
These ideas should be

documenting

my

'credentials'.

pleased to hear that Fred is working actively. Tell him
that the galley proof of the heroin/EEG article was recéved this week;
that naloxone is a much weaker antagonist when given orally even at
l Gm/day than methadone (the latter is effective at 100 mgm/day for
48 hours against 50 mgm heroin IV); but that we are continuing the
I

am

studies nevertheless.
My

'

best regards.
Sincere

Max

y

Fink,

yours,
M.D.

�</text>
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                    <text>-..

..~

m.

l...

g, i; rm
\k.

min

.M;

{C 0

December 28, 1968
Dear Jack,
Thank you for your letter and I am enclosing some
which may be of interest and some comments. First, however,
about EEG~~ I have no argument with spectral analysis except its
expense for the missions which I have set for myself, i.e. the
measurement of drug induced changes. For these purposes, every study
shows an equivalence for period analytic and power spectral methods-and the period methods, when done carefully, are ever so much less
expensive. At present, I can do either eaeily and do use whichever

articles

lends

itself to the

analysis. For
spectrum.

A8

n

for

problem at bend. For simple drug changes, period
detailed analysis of the faster frequencies, power
LSD.

to answer. Despite

my

This is a very difficult question for me
review of our data, and the report which

indicates that even (or especially) in chronic mentally ill we ran
risk of inducing psychotic episodee; I am also

a significant
aware that in

this group spontaneous psychotic episodes occur fre~
article is enclosed, as in a review from the Canadian
Mediecel Association Journal. This latter is the most complete to
quently.

Our

date.

position is to

tell

young people that experimentation
useful; but also occasionally den~
geroue. That experimentation with mind—altering drugs (and I always
tell them of the EEG patterns of these drugs) is probably the most
exciting experience possible, but also one that has risks (which
are usually described) and that the best experiments are done under
conditions where control is possible, i.e., n laboratory. I have
offered some the use of the laboratory and the drugs themselves, and
have had afew takers. Another risk in the fact that the supplies on
the street are often impure and ndultercted. I tell them about the
heroin supplies which we get free the FEE and which have recently
been 80% 'pure'; of the THC samples that were amphetamine and ecopolemine;
add of the LSD that was ecopolemine (each analysis in ourbleboratoriee).
my own

is always exciting

and frequently

The most difficult problem
more like alcohol and less

is the question of marijuana,

like

which

is

in probably safe even in large
doses; in non-addicting in the usual sense. and surely less so than
nicotine and alcohol. Our community is psychotic about this drug,
LSD;

�-3and the

irrational approach has clouded the probable real risks of

the other hallucinogens.

Perhaps the greatest approach may be to agree with the
students that their futures, if males, is indeed bleak so long as the
war continues; and that escapism is a normal approach and desire; and
that various escapes are possible—~ hermits and other isolation
devices; drugs and other temporary mind-clouders; emigration; or
identification with a problem or mission in which the sense of
participation and 'being with it' may be more satisfying than any
of the withdrawal defenses. The team roles and the gratifications
have been

also useful.

In answering such questions (and I have frequently) I am
: and tell us
not embarrasses by the question of 'Why do you
that it is bad for us?’ since I have tried all the drugs and dd not
use any now; and when the question of alcohol, smoking, barbiturates
or amphetamines come up—— it is easy to state that these are not
useful when other devices of adaptation suffice. The biggest question
in students is the difference between their parental or teacher's

statements and actions.

How useful these approaches are will not be known. The
kick has stopped in New York and the incidence of admissions to
hospitals have dropped significantly. In large part, this is the
result of the (mistaken, I believe) notion that LSD is specifically
dangerous to genes. The eveidence does not convince me and I do not
use this 'scare' other than to remind the questioners that there
are many effects of drugs that we are unaware of—~and tell them of
the interesting studies of thalidomide and pregnancy.

LSD

These ideas should be sufficient for the present. In view of
the possible additional help, I am enclosing a nre~print of a study
of hallucinogens that I completed last year for the ACNP and which
will be in press in the spring. This describes the central effects
of two large llasses of hallucinogens in man and has been useful in

docuﬁenting

my

'credentials'.

I am pleased to hear that Fred is working actively. Tell him
that the galley proof of the heroin/EEG article was receved this week;
that naloxone is a much weaker antagonist when given orally even at
l Gm/day than methadone (the latter is effective at 100 mgm/day for
48 hours against 50 mgm heroin TV); but that we are continuing the
studies nevertheless.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>December 28, 1968
Dear Reg.
1

an,plaased that 133 will canparate with ch¢ Intatnatianal
am writing to suggest some specific details that
the daaonatratians mare mental.

Congress, and I

would make

1. Tha programs

the exhibteiun.

will raquire

a fsw days of dabugging befara

for the éamonscratton shgald be available
a: least one «ugh bafora the axhibitsan, anﬁ beak the axhihitien hall
managers. the shipgors anﬁ 13% abould bu aakaﬂ co agrxe tﬁat the
exhibiclaa actually will be for the period Septamber 6/7 to 20.
2.

Va

The spngm

will plan to damoncttacc

from cages or from a

liva subject.

aha kinds

cf analyaas

um

dc,

For tapas, we will require a 1/2 inch SPBOO Ampux FM
recorder. To damnnatrate the plat pregrama, we use a Tektranix
osailloseope with a long pcxnistancc scruen cad a Palarmid camara.

is

EEG,

In damonstrate that what

parhapa an

EEG

19 caning ﬁrom the tap&amp;
channel from Grams wanlé ha uneﬂul.

for a liva demcnatration. thure will have ta bu
an EEG (Wt pretax Grass) and a band»pass filtar, and a chhhait
would be moat usafal. we vauld like ta show the dfﬁacts of
pentothal and this will allaw us to ﬁamonatrata our mathematical
model at the pantothal response. It may bu less useful in vnlunteers

than a demonstration of a hallucinogtn or a dimpla alarttng experiment.
but wn will tailor tha axperimcntal details to tha setting anﬁ the
ether axperimenta 1n the program.
My

best regarﬁs.
Sincarely yours.
Fink, M.D.
Profnsaor af Psychiatry

Max

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                    <text>Dccember 28, 1968
Dr. E.

J.

031119

Arsenal, Toulon. France
Dear Dr. 081113,

I an pleased to accept your kind invitation to participate
in the summer course on 'Automatic Processing of Electtobiological
Data‘ in Toulan betwoau June 16 and 27, 1969. I ptafer June 23 to 28
an that will allaw me to bring mambars of my family to Europe for

holidays as well.
Our

L'JWKW-W'vv-ﬂ-WWWW

develeping methods
to mascara the offsets of paychoactive drugs on the human scalp EEG in
the alert subject. The methads used are period analysis, pave: apactral
denaity, amplitude intagraticn and variability measures. we would
find it not: useful, in View of the astaemad participants and chair
uxtansive axperianue, t0 present an extenﬁed report of various studies,
under the title:

ﬂigitaz

1
,.

Ahmynm.

y-v.‘

pp.”

«$755

,,_

w-npg-z'xwy-H

u
H”

,

"rl'w'v'v'ﬂr’r-v.

"pt-r

7—9»

laberatoriea have been inatrumantal

1n

Computed Analgai¢ 05 UAug Speciéia Signaiuaeb
Making Human EEG.

in the

canauthor for this precannation will be Dr. Donald M. Shapiro, 0.82..
the Director of tha Division of Bicmnndical infatuation Proceusing of
the New York medical College.

My

Less than a full opportunity ta prescnt out data and
extcnoiva augerience will not justify our undartaking such an
axpcnstvo trip, and I would uncourage the commitcen to give conntld
station to this suggestion.

Incidtntally, I have not receivad the cauwunication of
June 18, 1968, and if this contains additiantl information, it may
be useful for you to sené us a cogy.
enclouad.

The

application

forms

for both Dr. Shapiro

and mysalf are

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>December 27, 1968
Dr.

hiiiiam Tabor

1407 Cummings

Richmond, Va. 23220

Biii.

Dear

Enclosed are the corrected butnperazine report forms.
principal difficuity iies in our interpretation of the item 15
and in the inch of discrimination among psychiatric diagnoses.

The

interpreted the item is as

a sampling of the
dosage periods.
occasionniiy
the maintenance dosage; more usually. the maintenance dosage was
somewhat less. The report shows the iargest period of sustained drug
effect. On each, however, we have indicated the maximum dose as
We

had

The maximum dosage achieved was oniy

we

.

Aiso. the date stopped was interpreted as the date of the
report period. In some instances. patients continued
report period. This was occasionaiiy noted on the summary
(narrative) which was written after the summary (report form) was

end of the
beyond the

compieted.

ﬁiagnoses are

all variations of schizophrenia. In some
domponent was given credit in the natretive

instances. the depressive

summary. although chronic schizophrenia was the principai diagnosis.
The use of catatonic, paranoid or simpie subtypes wateadditivo; and

chronic schizophrenia is the principei diagnosis.

trust these corrections cierify the questions.
for bringing these discrepancies to our attention.
I

Thank you

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

of]

�</text>
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                    <text>December 27, 1968

Dr. E.S. Paykel
Yale University School of Medicine
New

Haven. Connecticut

Dear Dr. Paykel,

I have recently read the report 'Trial of Imipramine
Patients' with considerable interest.
In re«read1ng the retort, I eannot find the data of the clinical response
of the subjects, 1.e., t*teets for the poat~pae drug conditions
for the behavieral measures. Table III indicatea that the differences
between drugs were not aignifiaant-~ but did the drugs affect the
clinical symptoms in the dosages given?
and Chlorpromazina 1n Depressed

appeared elsewhere, and if so, I
the tables. It may be that tha
the drugs or the sub—groups may
clinical change. partially related
to the dosages of chlorpromazine and imipramine selected; dosages
which you indicate are much lower than our own.

this ﬁata has
grateful far a copy of
lack of differentiation between
have haen the result of limitad

would be

Perhaps

It was a pleasure to read the report, and I look ﬁctward
to hearing of equally interesting studies from New ﬁaven.
Sincerely yours.
Fink, M.D.
Professor of ?sychiatry

Max

mil

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                    <text>December 27, 1968

Prof.

C.

J.

Miran

Department of Biological Chemistry
University of Athons School of Medicine

Athens (609) Greece

Dear Professor Mirna.

It has been none months since we last wrote and in this
have boon fortunate to obtain a supply of marijuana and of
THC from the National Inotitute of Mental Health. Supplies of both
are severely restricted and it may yet be necessary to ondortako
work in your laboratory.
timo

we

have begun the first trials and havo observed definite
which
effects
are more prominontnnt dosages of 20 mg THC than
15
and
10
5,
are even greater for smoking marijuana. V! have
mg;
or
nodo up cigarettes o£09.5 Gm nook. containing less than 11 THC.
The smoking of one cigarette yioldo EEG effects, but 2 cigarettes are
very definite. 'Theso trials are very preliminary, however, and
will be soon weeks before we are sure of the data.
We

EEG

it

I on planned to tell you that Dr. Martin Xeeler of Durham,
North Carolina, who has written about tho toxicity of marijuana. is
joining my staff in July. We plan to ostablish a marijuana resoarch
project before then, and will try to use the fooilitioa of the
International Association for Payohiatric Roscarch to sponsor the
collaborative aspects in

an

application to

RIMH.

in April and again in May. As soon
as my schedule is crystallized, I will write an&amp; plan to visit your
laboratory. Boforo than, I hope to send you an outline of a proposod
project as the basis for our discussions.
I will be in

Many

Europe

thanks for your Christmas card~~

my

associates

and I

appreciated the special opportunity to one the lush marijuana
growing in your back—yard. Profossor Freedman and Dr. Simeon
join in sending our boat wiahos for a successful and prosperous

New

Year.

Sincerely yours,
Max

Fink, Md).

�</text>
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              <elementText elementTextId="36008">
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                    <text>Dacember' 26 , 1968

Library,
of Medicine
103m Street

Academy
New

York,

N .Y.

Gentlemen:
me.

If

Ir.

Rhea Dorhbush

she finds

journals, I

would

is

working on a project for

books and
it necessary to take outher
do

appreciate your letting

so.

Sincere1y ,

Max

Fink , M.D.

Professor of Psychiatry

�</text>
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                <text>Correspondence to: Library at The Academy of Medicine</text>
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                    <text>December 26, I968
Dr. Stanley Feldsfeln
255 Wes? abfh

New

York,

New

Sfreef

York |0024

Dear Dr. FeldsTein:
The Infernaflonal Assoclafion for Psychlafrlc Research
ls pleased To have you as a momber of its research sfaff
a? an annuai salary of $3,500.00.

look forward +0 having you participafe In our sfudy
pregrams bofh a+ 102nd Sfreef and af Gracie Square Hospital.
I

Sincerely yours,
Fink, M.D.
Executive Direcfor

Max

MF:kp

�</text>
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            <elementTextContainer>
              <elementText elementTextId="36032">
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                  <elementText elementTextId="102714">
                    <text>December 25, 1968
Mr. John Balah

Science
Washington, 0.0.
Dear Mr. Halah,

I hsvn read your rcport, "Eutectic: and Drug Abuse: Tao
Fadcral Raapanse" with much incarnat; capaciglly an it accompanicd
a report an marijuana rcacarch by a nedicnl atudunt. The taper:
nugauats that yea urn preparing a taper: an HIKE resaarch in mgrijuana.
I am writing to suggest that if yau wish additionnl data regarding the
impaet of Federal tttitudas on tcucareh in substance abuse, apacifically
raseatch in marijuana. yen may with to arrange to discuss our expartcncea
during the-past fuw years.
Our cantor has bean active in resourch 1n Opiatt addiction. and
ch: stuff consists of aeteatists with many years cxpcrtauce in clinical
and exparimental phnrmacelogy. Despitn adaquata cradentialn at ware unable
to obtain legal auppliaa of marijuana frau May. 1967 until Rabamber,
1968-~ and only obtained son: unpplies from MINE «ban a photagraphor,
making n film on roseareh in narijuan for RINK, csllad to clear the

aupplica so that his film could be unﬁt.

Concurrent with this limitation, vs art now inhibitad from
raauonable cesaarch stadium of unthadone by local nuthoritias. not
because tha study in dangaroun (sine: um are doing the can: study with
more active and less well studics drugs) but beeausa uh: aura of
addiccian parvadas the scientists judgmanta.
-«-;..

‘
.

.,~

m.

'1'“

,

apparent that Fadaral authorities hava arrogatod
which thcy are unable to handle, to the eventual
dutrimcnt of carious clinical research. Perhaps your raview may
reflect song of the axperiences which have marknd the past few
years in this nignificant area of raseardh.

It is

rcsponnibilitica

w

Sincerely yours,

‘r~

muuuv

M

-v-

Ha: Fink, M.D.

I
gr

Professor of Paychiatry

u-w-r—t

Irvx'var-a'v“?saw-”gnaw”

"mg-angs

ml

�</text>
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                <text>1968 </text>
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            <elementTextContainer>
              <elementText elementTextId="36042">
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          <element elementId="48">
            <name>Source</name>
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            <elementTextContainer>
              <elementText elementTextId="36043">
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                    <text>Dceembar 25, 1968
Dr. D. 81v: Sanka:

Creednoor Stung ﬁanpital

Queons Villnga, ﬂew York
Dear Dr. Sankax.

It was kind a: you an invite me to partieipatu in the
recent symposium. and I found the sannian I ataanded most interesting
and rewnréing. You any rocall that I tank the liberty of turning over
my time to Professor 51:1 Roubicak aha had racantly arrived to join
my staff from Prague. I balieve he has submittad his discussion.
with which I concur.
own. and

It was my imprusnien that his summary substitutnd for
I trust that this meets with your approval.

bust wishes an the success of the valune, and
and
happy ﬂew Yaar.
prosperous
My

my

for a

Sincerely yours.

as: Fink,

M.D.

Professor cf Psychiatry
mil

�</text>
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            <elementTextContainer>
              <elementText elementTextId="36052">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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              <elementText elementTextId="36053">
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                  <elementText elementTextId="102716">
                    <text>Decaabar 25, 1968
Mr. John Walsh

Scianea
Haahinxton, 0.0.
Daar Hr. Walsh.

hava :aad your raport, "Eaxeotica and Drug Ahuaa: Tﬂa
accaapaniad
Padaral Raaponaa" with math intaraat; aapaeially aa it Tha
atudant.
report
nadical
by
a
raaaatch
a report on marijuana
HIKE
in marijuana.
raaaarch
an
a
raport
praparing
auggaata that you ara
the
data
ragarding
additional
wish
that
you
if
I an writing to auggaat
impact of Fadaral attitndaa on raaaareh in substance abuaa. apacifically
raaoarch in marijuana, you may with to arrange to diacuaa our axyariaucaa
1

”7-."

mun-cw

"—7

-

during the past faw yaara.

cantor haa been active in raaaarch in opiata addiction, and
tha staff coaliata of aciantiats with many yaara axparianta in clinical
and experimantal pharmacology. Deapita adequata credentials an uara unable
until Rohanbar,
to obtain lagal suppliaa of marijuana from May. 1967
whan
from
ulna
a photograpbar,
l968~~ and only obtainad aoaa auppliaa
to clear the
callad
RINK,
for
waking a film on raaaatch in aarijuan
be
aada.
could
auppliaaﬁao that his film
Our

Concurrent with thia liaitatiou. wa ara new inhibited iron
reasonabla aaaaatth studiaa of nathadona by local authoritiaa. notwith
bacauaa the atndy in dangeroua (aiuca we at. doing tha aaaa atndy
mora aetiva and laaa wall atudiaa drugs) but haeanaa tha aura at
addiction parvadaa the aciantiata judxnanta.

apparant that Vadaral authoritiao hava arrogatad
the avantual
raaponaibilitiaa which thay are unabla to handla, to raviow
may
Perhaps
your
datrinant of aarioua clinical research.
few
aarkad
tbs
hava
which
past
raflact aona of the axpariancaa
years in this significant araa of raaaatch.
Sincerely yours,

It is

Ma‘

Fink.

MOD.

Protease: of Paychiatry

“3/

�</text>
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              <elementText elementTextId="36056">
                <text>mfp-05-00-022-6-545</text>
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            </elementTextContainer>
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            <name>Date</name>
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                <text>1968 </text>
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              <elementText elementTextId="36058">
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              <elementText elementTextId="36060">
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="36061">
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            </elementTextContainer>
          </element>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="36062">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="36063">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="84369">
                <text>application/pdf</text>
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="90930">
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          </element>
          <element elementId="37">
            <name>Contributor</name>
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            <elementTextContainer>
              <elementText elementTextId="97491">
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      <tag tagId="4">
        <name>Correspondence</name>
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  </item>
  <item itemId="3607" public="1" featured="0">
    <fileContainer>
      <file fileId="2091">
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            <elementContainer>
              <element elementId="52">
                <name>Text</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="102717">
                    <text>‘Nr-‘Mﬁm‘~lv‘-

-mgwywwvr~ WV".

. 7-»..‘7, w—m

nu-vu

w

~

1

w

,.

'm wv-va‘JvF—m

Docgdbar 25, 1968

Dr. Vinccnt Dole nné Katie Ryswnndar

nockatellcr University

New

York 10021

Dan: Vine. and Marta,

I have read tha report in the J.A.K.A. and the progrcia
mathndonc program and wish ca aongrntulatc both of
of
the
taper:
n
for
htroic
jab v.11 donc. Although I can. into the narcotic
you
trcstnnnt warld quit. raccncly, I havn axperiencoé many of tha
ﬁéldﬂilttlti?‘, palitical and idaological ntupidititc that aunt

ctforta; and to haw: bccn so succetaful, dcspttc
than: hurdlot. in inanad an achievamnnt. Congratulations !'

have nurknd yaur

Our awn studios luppatt your taper: fully, and I
haw. already cxprtnsad the aplnion that the principal battla has
beta won and that repair opurationn are new neadad. H. at.
prcpnring a au-nnry of our vacant comparison of cyclazoeina and
Inthadanu and this will b: oubataatially supyortiva. Also,
in our EEG studicu of heroin ahallnngoa, the duration 0f mathadonn
untsgouilu is longer than we had antietpntad 3nd 1t: potency incrca-n:

with zinc.

Hy

congrgtulaciona on a job wall done.
Sineoruly yourc.
Fink, 3.9.
Praia-nor of Psychiatry

Mn:

�</text>
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                    <text>«

4».

q
.1-

w-‘n-vu—rn

u

December 24, 1968
Dr. R. Reich Canaan

National Rnsoarch Council

inshington,

D.C.

Dear Dr. Canaan.

Previously, Dr. yraedmnn has submitted the titles of three
prosentotiona for tho 1969 matting: of the NRG~RAB Committoa on
Problem: of Drug Dependence. In roviawing the data of our comparative
study of cyclazooino and methadone in the craatmant of oyiato dopandcnce,
we helluva that the present uxporianeas will be of more relevance
to the prosont issues in drug dapondance than sons of other
reports. and I am writing to euggoat your consideration of tho

report,

Typologieal Approach to the Tﬁernpy of Opiate

Dependence by Cyclazocine and methadone
Richard Rosnick, M.D., Max Fink, M.B. and Alfred
M.

Fteeémnn, M.D.

Conaidering the negative nature of tho rcpotc, "Tybauata in the
Treatment of Opiate Dependence". we would auggaac withdrawal of

this presentation, if the
Thank you

program

is already congleted.

for your consiéeration.
sincerely yours,
Pink, M.D.
Professor of Paychiatry

Max
MF/

�</text>
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                    <text>December 24. 1968

'

Mr. Herman Heisman
Hoffmnnn La Roche Inc.

Nutley,

Raw

Jersay

Dear Mr. Waiamnn.
we

have received

Va

art

chm

galluy proofs a! the

articla

on

high dose Libriun from ch. Thnrnpnutic Ransarch Press and are
rcturning than with a few corractiona. Thu atrial. will appear
in the January issue of Curran: Thnrapauttc Resenrch.
Granting the minimum quantity of reprints (1000)

will arranga to ship the majority to you, if you wish. If.
in addition, you wish othct reprintu, plans. call my ofﬂico 3nd I
will amend the raquast.
and

my

Again. my thanks for your cocpcrttion and interalt:
best wishes for a prosparous and happy ﬂaw Year.

Sincercly yours.
Max

mf/

Pink.

M.D.

and

�</text>
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                    <text>December 26, 1968

Therapeutic Research Press. Ina.
Tenafly, New Jersey
Ganclansn:
Enclosod in our 0:30: for 1000 raprintn of the article
by Taylor,¢t 31., "Sign Dosa Chlordigzepoxide Therapy of Anxiacy”.

Please chip

300

reprints to:

Max Pink, M.b.
5 Eaat 102 Scrum:
Haw York City 10029

and 700 noprints

to:

Mr. Earnnn Vaiamnn

Squior Clinical Research Assaciatc

Hoffwan La Rocha, Inc.
Hutlmy, ﬂew Jersey 07110

confirming purchase order will be sent by the New York
Medical 6011030 on my behalf. Aftur shipping plausa send the statement
in full to me fox approval for payment.
A

Thank you

for your coopcration.
Sinceraly yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>Decembar 24, 1968

Dr. Vincent Dela and Marie Ryawandcr

Rocketeller university

new York 10021

Dear Vines and Harte,

I havc read the report in thc J.A.M;A. and the prograc:
report of the mathadana program and with ta congratulate both of
you for a haroic job wall done. Although I came into the narcotic
treatmnnt warld quite recently, I have experiencad many of the
administrutivc, valiticxl and idnolegical stupiditica that must
huva unrkcd yaur effarta; and ta~hnwn been so auacesatul, daspita
those hurdlcs. is indaad an achievumant. Congratulation:

!'

Our own atudias support yaur tapers fully, and I
have already cxvrassad tha opinion that the ptincipal battle has
beta won and that repair operations are ﬂaw neadad. We are
prcparing a summary of our vacant eonptrison at cyclazoctnc and
nathadone and this will be substantially supportive. Also,
in our EEG stuﬁien of heroin challengms. the duration of methadong
antagonism is longer than at had :nciatpatcd and
potancy increaaas

it:

with time.

‘

My

cougr‘tulations

on a job wall done.

Sineoraly youta,
Fink,
m
Ptafesaor of Psychiatry
M. BO

mil

�</text>
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                    <text>Hannah»: 24, 1968
Dr. Charles ﬂunn
Endo

Laboratories

Gardaa City.
Bear

9:.

Raw

York

Dunn,

Thank you for the extensivn literature on moltndona.
havn read
with grog: innatest, and tha data sugportn the
suggestion that malindonc 1. an attentive antipsychotie agent.
It; naval chcmianl structure recommends curly admission into
clinicnl pharmacology to providn an alternuca treatment for these

it

I

it:

patients not responding to «stabllshnd antiptyehctic drugu.

vagld 11k» to undertaka cliniaal trial. with mnlindanc.
Unfortunately. I do not hava an in-patiunt population of actively
psychotic patients for altnical drug trials. In our out~pationta
wa are (cannula; on thou: compounds which have had a prior EEG
aliasification stuay.
we

matcrial.

my thankl for the opyortunity to road this
best wishes for a auccensful Kaw Your.

Again.

my

Sincerely yours,
Max

Fink,

M.D.

Profasser of roychintry

mf/

�</text>
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                    <text>December 20, 1968

Dr. Edwin Dunlap
150 Emory

street

Attleboro, Mass. 02703
Dear Ed,
—.—,

cu

rn—m

I enjoyed the meetings in Freeport very much, and
wish to congratulate you and the other afficers for preparing
a fine program.

.

-m‘-vgs.

.
Mrs".

m

.

:

,‘wy‘y...’

.

.-a'

'2

xvi-Ulﬁs'

.A

It was suggested that I write to you for the necessary information regarding mambatship 1n the Academy of Psychosomatic Medicine.
I

would be

grateful for

any information

that

may

be

available.

Thank you.

Sincerely yours,
ﬂax Fink, M.D.

�</text>
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                    <text>December 20. 1968
Dr. Loon Rackaw
Franklin E. Rooaavalt Hospital
ﬁentrcse, New York

la N

Dear Dr‘

f

thkow.
Dr. Roubieek and I wish to thank you for tha splendid

welcoms and

interesting visit that

we

had

last

weak.

I

have

also

received the notes you sent ané haw. read chaos before sending them

on

ta

Dr. Freadnnn.

opportunity to: rasaatch at your hospital era indeed
I
will
encautnge Dr. Freadmnn ta establish the ralationahip
bright
which will paruit somber: of this staff :0 participata 1n the
special programs whiah the VA has aatabliahad. In reading the
reportn. I van most interested that half the patiento ware nude:
44 ycurs of age and that of theta, half taunincd less than two wecks,
suggesting thgt the population is more acute than was initially repr¢~
and

The

canted.

Again. our thanks fer year enthusiasm and I

Ftoaéman and the

visit

noon.

staff here will

trust

havu an occasion to discuss

Dr.

this

lineeraly yours,
Fink, M.D.
Prafesuor of ?aych1atty

Max

�</text>
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                    <text>December 18, 1968
Dr. ﬁcxean Cattoll, Editor
Journal of Clinical Pharmacology
and New Drugs

525 East 68th

ﬂew

Street

York, New York 10021

Dear ﬁr.

Cattell:

Enclosed is a copy of "High—Dose Tybamatc Therapy of
Heroin Dependence“ for your consideration for publication
in tho Jowmaz 05 Curated. ”modem! and New vauga.
This study roprosents part of our continuing evaluation

of treatments in opiate addiction.
Thank you

for your consideration.
Sincerely yours,
Max Fink, H.D.
Professor of Psychiatry

Mthp

�</text>
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                    <text>December 18, 1968
Dr. Walter Modell
Department of Pharmacology

Cornell University Medical College

1300 York Avenue
New York, New York 10021
Dear Dr. ﬁodcllz

Enclosed is a draft capy of "Electroencephalograms,
Mental State and Psychotropic Drugs” for ”Pharmacology

for Physicians". I am most grateful to Dr. Hollister and
yourself for your kind invitation, and for his critique.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>W

1'7, 1968

Dr. Richard Bmtmsn
Bepartment of Psychiatry
1m York Medical College
5 East 102M Street
New York, 24.15. 10089
\

Dear Dick:
The Unitad States mamas Laboratory in Baltimmm
called to say that the sample submittad contained no
THC. Their gnaw (and it was ml)! a guess) is that
, as thay have
W tablet naming of washed
seen aimlw amen befom.

W1

Sinaemly

yam,

rm Fink, 24.23.
Mfessor of madam
Hf‘mr
.

.
w

“warm."

ac: Er. Alfmd
rmﬁ-me

t“:

law'vﬁ-zﬁw‘1..:n1/-‘&gt;=w-JT;vu,

a

H.

mm

�</text>
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.—,....,.A

..

December 17, 1968

Honorable Norman P. Lent
Chm.,

Joint

Committee on Health

State Capitol

Albany,

How

York

Dear Senator Lent,

I am writing to roquest sarious consideration to the
potential hassrds in tho proposed amendmont to the public health
law in relation to human research (8. 4015A, A.5586A). I have read
the proposed amendments and find them too restrictive in their

text with regard to the continuation of research;
definitions of 'roscsrch'.

and too vague

in the

Since 1952 I havo been engaged in rosesrch in montal

illnesses. with specific sophssis on treatmouts using biological methods.
First at Hillside Hospital in New York (1952~1962),thcn as tho
director of tho Miaaoori Institute of Psychiatry (1962~l966) and

at the New York Medical Collage whore I am Director of the
Division of Psychopharmacology and Drug Addiction. I have found that
none of the techniques which are needed in the study of man van be
carried out in animals. neural illnesses soon peculiarly human
frailtieo, and their study, while raconmonded it animals by others, are
totally unsuccessful. Progress in treating the mentally ill seems to
cons only from studies in patients, as with convulaivo therapy,
the many now drugs, and recently, in the treatment of opiate addiction.
now

At present, our emphaais is in the biological troatment of
opiate addicts. The peculiar nature of the illness, and the methods
which are now useful ( methadone maintenance, cyclsrocine and nsloxone
antagonism) have been developed in patient studios.
The proposed law suggests that all studies will have to be
cleared by a committee, half of whom will be laymen. Considering the
difficulties with methadone maintenanco with Federal authorities, and
initially with state authorities, I am sure that such a committee will
prevent any research which at the timo may be considered hazardous,
thereby preventing progress.

Lot mo cite a specific example. In our studies of mothadouo
inttho traatment of addicts, we have measured the affects of methadone
on brain function and find that the changss ara so like some that
we have found useful in the treatment of severe schizophrenic
patients,
that we proposod a study of methadone in the therapy resistant psychotic

�Senator Lent

December 17, 1968

2

pationta at our institution. The proposal was carefully reviewed
by our College committees and approved. 0n referral to the Commissioner
of hospitals. howovor, the proposal was dioapproved since mothodone
is considered an dddicting drug. It is strongo that laymen are
for when all hopo has been
willing to allow the severe montally
nbandoned after all other mthodc have been tried, to forgo a potential

ill,

therapeutic benefit, out of fear.

All research must be daring to be oudcasaful. All human
research can ho monitored by our poets, and the present committees
have shown themselves to be useful. Since their introduction during
tho post foo years at the urging of the Federal granting agencies,
it aaams premature to antablioh another mechanism bofore this one is
‘fully established.
Specific objectiona to the logialntion are as follows.

will consint of laymen in the majority. Modern
too
complcn
to be rovicwed by tho laity except when one
tachuiqcos are
hoscl
no
oxpocts responses
prejudice and emotion. Research cannot be
omotion
and
be judgod by roaaon«~ whcrovor poooiblel
should
by
judged
The Comoiosion

will oit far away from the site of tho
rosoarch. It goons that there will ho only one full time mentor, and
it is inconceivablo tact tho alto of the roooarch. tho qualifications
of the investigator, and the Quality of the protective devices can
The Commission

be monitored omcoyt in tho locale ohcro the study

is done. If a committee

of visitors is established, than the device will be overly cunbersono
and oxponoivo.

conflict hatwocn reoearohy at poorly dofinod, and
medical
treatmont as
practice, is not rcoolvod by the logiolntion.
If I treat a patient with a new treatment will this ho exempt if
I on paid for it as part of medical practice; but not exempt if
done for no fee as part of a research program ?
The

The problom of consent has been adequately discuoood
Fodoral
in the
legislation of a tow years ago. Thorn are special
problems in dealing with the mentally ill, and the propooed atote
legislation does not dofino the safeguards which experience has shown to
be useful and necessary.

There are othor problems which are not

clarified in the

bill. It is regrettod that tho legiolnture finds it necessary to
propose state legislation io.an «tons where existing legislation.
if adequately administered. would be most odoq’nto to protect our
fellow citizans and ourselves. American research has been in the
forefront in all fieldo except in the care of the mentally 111. Most

of the modern advances in their treatment have coma from Europe. In
part this resulted from our ovcrinvoatmont in psychotherapy; and
in port. from the restrictions placed on research in our institutions
for the acuto mentally ill. The addition of this burden, on oxemplified
in tho proposed lcgiolation, will handicap Amorican research even
further- for such legislation is unlikely to remain restricted to
our stotc. since we have been a bollwoathor state.

�Senator Lent

December 17, 1968

3

In writing this

letter, I

on

acting

on my own

behalf

as Director of the Division of Psychophnruaoology and Drug Addiction
of the Department of Psychiatry; and as tho Exocutivo Diroctor
of the International Association for Psychiatric Research. Inc. The
IAPR was established in 1967 to provide a nochonisn whereby collaborative
research could be undertaken in othor localities where the restrictions
were less stringent. Because of limitations in committee actions
at the Federal level, we have undertaken some important research in
trottnont of mentally
in Istanbul, thoroby confirming studies
We hnvc also begun a study of
from
France.
originally reported
marijuana in Greece since the restrictions imposed on the study
and sunply of this impotttnt agent in the United States have been
so great that wn havo had to go through multiple oomnittons and
18 months delay before undertaking ouch studios in New York.

ill

Your consideration of these comments

is appreciated.

legislation will, in our opinion, do more harm to our
citizens not ouroolvos than any potential good that may be imagined.
Your oomnittee's disapproval is roquooted.
Tho proposed

Sinceroly yours,

Fink, PhD.
Profossor of Psychiatry

Max

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                    <text>December 12. 1968
Yellow Springs Instrument Company
Yellow Springs.
Ohio
Gentlemen:
I would like to record temperature changes in man
from body surfaces such as the inner thigh or earlobe
and orally. The changes will be small and we would like
to be able to record them as rapidly as possible. We
are equipped with a Grass Model VII polygraph.
May I request your recommendations for the appropriate
thermistor probe for these applications. we will require
two probes for each application and an appropriate tele-

thermometer.

Thank you

for your recommendations.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>,

_.

my».

-«-,_.-

»

...,,.- .q‘.

.

.m;

5.. «pt-.11

an, m.” ”or, "FKJ:
w—

u.

,4:.‘,:’

s,

‘:_-lru wwr-r- -'I,r'~)lp.‘r'7"l.pawn--

awn

M—z'vw

December

'\ '

raw-«um: .

l2.

-—..,—./

.

-,

~.-~am--.n

-.'v'

1968

Yellow Springs Instrument Company
Yellow Springs,
Ohio
Gentlemen:
I would like to record temperature changes in man
from body surfaces such as the inner thigh or earlobe
and orally. The changes will be small and we would like
to be able to record than as rapidly as possible. we
are equipped with a Grass Model VII polygraph.

request your recommendations for the appropriate
thermistor probe for these applications. we will require
two probes for each application and an appropriate tele~
May I

thermometer.

Thank you

for your recommendations.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>December

ll,

1968

Dr. Leon Hellman

Hontefiore Hospital
210 Bainbridge Ave.
Bronx.

New

York

Dear Leon.

discussed with you. I am enclosing a paper “Newborn
Sex Ratios Associated with Pre— and Post- Partum Process
Schizophrenia" written by Dr. Taylor who is one of our third
year residents. The problem is either a very important one.
as I think it is. or an interesting footnote.
As I

I would be pleased if you and Dr. Gallagher would read
and I would like to arrange an opportunity for us to
get together to discuss this further. Please call me as soon
as you have had a chance to read this report.

this

The report has been submitted to Science and until it
has been accepted for publication. I would ask you to use your

greatest discretion in discussing this report.
Sincerely yours.

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>ll,

December
Miss Violet E. Denison
Associate in Admissions

l968

-

Teachers College Columbia University.
New

York,

New

York l0027

Dear Miss Denison:
Miss Karliner was appointed to our department in
June l968 as a summer research worker and returned to
school in September l968.
She devoted her tine to the study of memory changes
in psychiatric patients. most of whom were elderly, in
our study of the convulsive therapy process. This study
is in progress at Gracie Square Hospital, supported by
the International Association for Psychiatric Research, Inc.
In her work Miss Karliner was supervised by Dr. Rhea

Dornbush, Ph.D., but I had the opportunity to meet with her
twice weekly. Both by my direct observation and by her
reputation at the hospital. she exhibited great facility
in dealing with the severe mentally ill - some of whom were
confused and most irritable. DeSpite the stress of dealing
with difficult patients, she always maintained her

able to stimulate cooperation even when
difficult. She was well liked by her associates
it
and achieved a good reputation among the staff. She is
emotionally mature. both for her age and on an absolute
standard.

equilibrium and
was most

was

I am pleased to
her chosen career.

recommend

her highly as

a

student in

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>December 11. 1968
Mr. Arnold Canter
Andrew Stuart Associates,
P. 0. Box 325

Purchase.

New

Attn: Mrs.

Ltd.

York 10577

E. Mascia

Dear Arnold,

Foiiouing is a list of employees now being paid by
the International Association for Psychiatric
Research.
for whom coverage is requested under the Workmen's
Compensation and Disability Insurance:
Salar
Dr. Richard Abrams
SS? 065-30o0071

Pauiine

Da

Costa

Psychiatrist

$1257mo.

054-44—3714

EEG

Tech.

186.67/mo.

R. Dornbush, Ph.D.

118-32—5789

Psychologist

250.00/mo.

J.

078-34-0868 Resch. Nurse

350.00/mo.

Suzanne Kraft

092-40-0020

EEG

Tech.

227.50/mo.

Lynn D. Kyde

125~38-2353

Resch. Asst.

390.00/mo.

S. Horwitz

K.

Peiczynski

is

P. 0. Box 269. Great Neck,

497-44-2537 Secretary

Please note that the address of record for the Association
New

York 11022.

Sincerely yours.
Fink,

Mex

M.D.

Executive Director

MF:kp

50.00/mo.

‘

�</text>
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                    <text>December

ll,

1968

Honorable Wallace Groves

President.

Grand Bahamas

Port Authority
Freeport. The Bahamas

,

Dear Mr. Groves:

visit to Freeport, attending meetings of the
of Psychosomatic Medicine, I was favorably impressed
by the tremendous progress and activity which I saw.
Representatives of one of the development companies indicated
In a recent

Academy

that there

was a need

fer additional medical service.

This Department of Psychiatry has extensive treatment,
research and teaching programs in community mental health.
We have talked of possibilities of expanding our programs
to other communities. to allow for the insights which come
from comparative studies.
I

do not know what

facilities for psychiatric care are

if

there is either a need for or
an interest in the development of a community mental health
be able to fulfill such
progran, it is possible that we may

available in Freeport, but
a

serv ce.

would be pleased to hear from the approoriate agency
of the Authority regarding this suggestion. Let me take this
Opportunity to congratulate you on what appears to be a
visionary and exciting program.
He

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Becember

ll,

l968

Honorable Wallace Groves

President,

Grand Bahamas

Port Authority
Freeport, The Bahamas
Dear Mr. Groves:
In a recent

Academy

meetings of the
was favorably impressed

visit to Freeport, attending
I

of Psychosomatic Medicine.

by the tremendous progress and activity which I saw.
Representatives of one of the development companies indicated
that there was a need for additional medical service.

This Department of Psychiatry has extensive treatment,
research and teaching programs in community mental health.
we have talked of possibilities of expanding our programs
to other communities, to allow for the insights which come
from comparative studies.
I do

not

know

what

facilities for psychiatric

if

Care are

for or
there is either
health
mental
an interest in the development of a connmnity
program, it is possible ' that we may be able to fulfill such

available in Freeport. but
a

service.

a need

.

we would be pleased to hear from the appropriate agency
of the Authority regarding this suggestion. Let me take this
opportunity to congratulate you on what appears to he a
visionary and exciting program.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>December 11, 1968
TO

WHOM

IT

MAY

CONCERH:

Mr. Staniey R011 was empioyed as a pregrammer on
January 15. 1968, to participate in our research program
app1ying digitai computer methods to c1inica1 psychiatry.
a

Mr. R011 devoted the majority of his time to interfacing
217 disp1ay scope to the IBM 360/40 and programming a

CBC

behaviorai rating sca1e using this device. During the initiai
months we had some difficuities with hardware but as these
were so1ved the programs were comp1eted.
Mr. R011

resigned effective December 15. 1968.
Sincere1y yours,

Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text/>
              </elementText>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>en-US</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="90950">
                <text/>
              </elementText>
            </elementTextContainer>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="97511">
                <text/>
              </elementText>
            </elementTextContainer>
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        </elementContainer>
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    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
