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                    <text>NEW YORK MEDICAL COLLEGE

NEW‘

FLOWER AND FIFTH AVENUE HOSPITALS

mmommum
CORRESPONDE‘

FIVE EAST IOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

July 19,

1968

Dr. Alan E. Smith
Deputy Director

Division of Anti-infective Drugs
Office of New.Drugs
Bureau of Medicine

Food and Drug

Administration

Washington, D.C. 20204
Dear Dr. Smith:

RE:

IND

2822

The studies Of cycloserine, with or without Dilantin
undertaken at the University of Missouri were completed in
the winter of 1965. Unfortunately, I moved from Missouri
in May Of 1966 and have not had an opportunity to summarize
the infOrmation. I have contacted one of my associates
and asked that the data be summarized.

study was discontinued in the winter Of 1965 and
each
the investigators were notified. The unused supplies
Of cycloserine were discarded in Missouri and are no longer
The
Of

available.

Sincerely yours,

W

Fink,
Professor

Max

Mszp

ﬂimwf‘é’“
M.D.
Of

Psychiatry

3

”Ct:

�</text>
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                    <text>July 31,
Dr. John Biel

Aldrich Chemical
2371 N. 30th

Company,

Street

1968

Inc.

Milwaukee, Wisconsin
Dear Dr. Biel:

It

pleasure to renew an old acquaintance and
ask you to provide us with 3 grams of
to
pleased
tetrahydrocannabinol-A-l (or 9). For our purposes. we would
prefer to have this amount made up in ampules containing
I am

was a

20 mg.each.

Ne possess Certificate No. 2l9l from the Narcotic Control
Bureau and are equipped to carry out research of marijuana as
approved both by the State of New York and the Federal Bureau

of Narcotics.

As soon as a price is determined, I would appreciate a
bid which I can submit to our Administrator.

Good luck and thank you

for your assistance.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July 31,

Ir.

Richard

1968

J. Tatham, Chief

Office of Alcoholism and

Drug

Addiction Program Development
Government of the

District of

Department of Public Health
Washington, 0.0. 20001

Columbia

Dear Mr. Tatham:
In response to your letter to Dr. Sharoff, I am pleased
to enclose copies of recent reports from this laboratori’which
describe our present program and experiences with cyclazocine.
In response to your specific questions, we have no plans
for the withdrawal of patients from narcotic use on an outpatient basis. The other questions are answered in the articles

enclosed.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

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                    <text>July 31. 1968
Dr. Wayne Jostrand
IBM

Corporation

475 Northern Blvd.
Great Neck, New York

Dear Dr. Jostrand:
would appreciate a quotation from
purchase of our installed 1800 system.
We

IBM

for the

Thank you very much.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Jul y 31. l968
Dr. Ralph Jacobson
Endo
lOOO

Laboratories
Stewart

City,

Garden

New

York

Dear Dr. Jacobsen:
Mr. Kline

delivered the naloxone -

many

thanks.

Dr. Zeks and I are discussing the details of our protocol
and we anticipate the need for placebo tablets at sometime
during the investigation of each subject. would it be
possible for you to supply us with lOOO identically scored

placebo

tablets.

Many

thanks!

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>F

I'

wee-v.“

an

-

”Liw

July 31,

1968

Ir.

Richard J. Tatham. Chief
Office of Alcoholism and Drug
Addiction Program Development
Government of the District of Columbia
Department of Public Health
Washington, D.C. 20001
Dear Mr. Tatham:

In response to your letter to Dr. Sharoff, I am pleased
to enclose copies of recent reports from this laboratori1which
describe our present program and experiences with cyclazocine.
In response to your specific questions. we have no plans
for the withdrawal of patients from narcotic use on an outpatient basis. The other questions are answered in the articles

enclosed.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
8M: .

�</text>
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                    <text>Juiy 31, 1968
Dr. John Biei

Aldrich Chemicai
2371 N. 30th

Company.

Street

Inc.

Miiwaukee. Wisconsin
Dear Dr. Biei:

It was a pieasure to renew an oid acquaintance and
piaased to ask you to provide us with 3 grams of
tetrahydrocannabinoI-A-I (or 9). For our purposes. we wouId
prefer to have this amount made up in ampuies containing
I am

20 mg.each.

We possess Certificate No. 2191 from the Narcotic Control
Bureau and are equipped to carry out research of marijuana as
approved both by the State of New York and the Federai Bureau

of Narcotics.
As

bid which

soon as a

price is determined,

I can submit

I wouId

to our Administrator.

Good iuck and thank you

appreciate

for your assistance.
Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

a

�</text>
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                    <text>August 1, 1968
Dr.

Clintin

Brown

Department of Psychiatry and
Behavioral Science
Johns Hopkins University School
of Medicine

Baltimore, Maryland 21202

Dear Dr. Brown:
I have

recently reviewed the available

methods

for

data and find the literature sparse and
unsatisfactory. While many observers have recommended various
computer methods for the automatic analysis of a sleep record,
these are generally very expensive or insufficient. At the
Society of Biological Psychiatry, Ardie Lubin presented some
data from his program in San Diego based on power spectral
density analysis.
quantifying sleep

My

a

report

EEG

former associates,

Itil

"sleep prints" based

on

Agnew,

Parker,

Webb

and Shapiro, have

on

written

period analysis.

and Williams have used amplitude

analysis for the classification of sleep

EEG.

I am confident that you know of others and I am writing
to suggest that the Program Committee consider the possibility
of inviting these workers (and others) to analyze a tape which
can be sent to each of them and to provide them with an opportunity
to describe their methods, ability to discriminate, expense, egg.
some

Such an opportunity would be a great help in clarifying
of the problems facing investigators seeking better methods

of quantification. My associates and I will be glad to do what
can to make such a symposium a success.

we

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: T.

M.

Itil,

M.D.

�</text>
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                    <text>August 1, 1968
Dr. Francis J. Braceland, Editor
American Journal of Psychiatry

l700 Eighteenth St.. N.W.
Washington, 0.0. 20009
Dear Dr. Braceland:

Enclosed are draft copies of two reports summarizing
our experiences with a narcotic antagonist, cyclazocine.
Following theoretical models which have been of interest
for many years, we found that cyclazocine had a neurophysiological profile similar to imipramine. These clinical

trials, in two different populations,
does indeed have significant clinical

indicate that cyclazocine
antidepressant activity.

We are aware that such open clinical studies are
ordinarily of limited value since enthusiasm may effect the

treatment outcome in depressive populations. But the
demonstration of a significant application of available
neurophysiologic methods provides our incentive to present

this publically.
He

and ask

would appreciate your consideration for publication,
that the two reports be assessed together.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc. (2)

�</text>
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                    <text>August

l,

1968

Dr. John C. Kramer

20l9 Camden Street

Riverside, California 92506
Dear John,
good news of your letter of July 14.
have heard of Irvine,
should be a great
university center, especially if some of the dreams of Gerard
come true in the application of computers to education. I would
be pleased to write a letter of reference. Do you want me to
send one spontaneously or shall I wait until I hear from them?
Thank you

everything

From

With a

for the very

it

I

little

luck I will be in Europe from actober l5~25.

Whether I am hate or not I hope that
you will
visit and I will arrange with my
staff to have you entertained and to show you our present programs.

This

may

not

come to pass.
have some time to

T e marijuana problem
a serious one although today
'l5 a UNQQUG day for me. sinceiswestill
did receive 500 mg of tetrahydro'
cannabinol from NIMH. This represents the supply that Jerry Levine
promised last summer. I was also called by Dan Efren who told me
that Aldrich Laboratories of Milwaukee are prepared to produce THC

for qualified investigators.

of the rumors from Washington regarding CNDA
or Psychopharmacolopy. The latest is that Sidney Cohen of Los Angeles
is taking Roger Meyer's place.
I know nothing

also received a large supply (probably
the world's supply) of naloxone for oral use and we will run clinical
trials during the fall.
In

addition to the

I look forward

THC I

to seeing you.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HFtkp

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                    <text>August

l,

l968

Dr. Turan H. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Turan,
have modified the laboratory data form to siit some
needs
of this laboratory. We are awaiting a new proof
of the
but I am enclosing a xerox copy of the latest draft available
we

to

me.

This will indicate some of the changes which we have
considered advisable after using the HIP form for the past
few months. These include color divisions between items;

exact values above the place to be marked; the addition of
items for standards. laboratory and route, which we believe

will

be

useful.

on a second form for medical examination
believing that a single sheet on a single side is the best for
and purpose. The laboratory form will be completed by a
We

are working

laboratory technician. We are working on another form to be
completed by a physician and/or technical research person and
this will include such items as weight, blood pressure and skin
and eye changes.
As

soon as a provisional copy

My

best regards.

to you.

is available

I

will send'k

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>August
Dr.

Clintin

l,

l968

Brown

Department of Psychiatry and
Behavioral Science
Johns Hopkins University School
of Medicine
Baltimore, Maryland 2l202
Dear Dr. Brown:
I have

recently reviewed the available

methods

for

data and find the literature sparse and
unsatisfactory. While many observers have recommended various
computer methods for the automatic analysis of a sleep record,
these are generally very expensive or insufficient. At the
Society of Biological Psychiatry. Ardie Lubin presented some
data from his program in San Diego based on power spectral
density analysis.
quantifying sleep

My

a

report

EEG

Itil and Shapiro, have written
"sleep prints" based on period analysis.

former associates,

on

Agnew,

Parker.

Webb

and Williams have used amplitude

analysis for the classification of sleep

EEG.

I am confident that you know of others and I am writing
to suggest that the Program Committee consider the possibility
of inviting these workers (anci others) to analyze a tape which
can be sent to each of them and to provide them with an opportunity
to describe their methods, ability to discriminate. expense. egg.
Such an opportunity would be a great help in clarifying
of the problems facing investigators seeking better methods
of quantification. My associates and I will be glad to do what
we can to make such a symposium a success.
some

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: T.

M.

1m. no.

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                    <text>August 1, 1968
Dr. Charles E. Marshall

Associate Director of

Clinical Research
Winthrop Laboratories
90 Park Avenue
New

York, New York 10016

Dear Dr. Marshall:
Some months ago we discussed a study of parenteral
oxypertine in volunteers. I have recently begun such a
study with one unknown compound and it would be convenient
at this time to introduce OXypertine as one of the
experimental drugs.

it

If such
with you.

is possible,

My

I

would be pleased to discuss

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

�</text>
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                    <text>August 1, 1968
Mrs. Virginia Hoyle

Assistant Editor

Annuai Review of Pharmacology
4139 E3 Camino Way

Paio Aito, California 94306

Dear Mrs. Hoyie:

Enciosed is our manuscript “EEG and
for the Annuai Review of Pharmacology.

Human

Thank you for the opportunity to prepare
I hope that
meets with your aoprovai.

it

Psychopharmacoiogy“

this

summary add

Sincereiy yours,

Professor of Psychiatry
MF:kp

�</text>
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Dr. Ralph Smith

Mayo

Clinic

Rochester, Minnesota
Dear Dr. Smith:
For some time we have been carrying out EEG analysis
using a 24K IBM 1800. The studies are primarily psychopharmacological and we are now interested in adding EKG
analysis to determine the changes that may be associated

with high doses of psychoactive drugs.

that

He

requested the assistance of

a program

for

at your Center. Is
documentation?
Many

EKG

it

IBM

and they indicated

analysis is available for the l800
possible to obtain the program and

thanks.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

its

�</text>
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                    <text>AuguAt 2, 1968

0L. FLLtz FLeyhan

Eston, CompLehenALve PLuehLatLy
3t. Uanent' 6 HOAthaL

neon FLLtz,

I

am

with Lego/cc! to the manuLcLLpt
Mug
ChLoLdLazepodee, aLone and combLned,

"ThLonthane and

Ln

SehLzonhLenLe PatLentL" umLeh you have eonALdeLed (on pubLLcatLon
Ln the jouLnaL. In checthq Lame copLeA Lent to me bu 0L.
HoLden, I 5Lnd that thEAQ have eonheetLon dateL thch nLeeede
the one Lent to uou 60L youL conLLdeLatLon. To avoLd any eLLoL,
I wouLd appLecLate youa estoLLaL aAALLtant cheekLng the capu
Ln noun handL.
0n the Aecond page, we have manhed the dnagt cap”
and the date. The LateL copy, Lon youa conLLdeLatLon, LL
manhed "10- 5— 67". An eaLLLea dhaﬂt, maahed "V: 5- 27- 67" AhouLd

not be

eonALdeLed.

I5 you have the connect capo, pLeaAe dLALegaLd

note. I5 you have the eaLLLeL dnaﬁt, pLeaAe
uuLL bend the Latea dnagt meedLateLu.

at a

LhLL

caLL mu oﬁgLee and we

I LegLet the LneonuenLenee, but a eonthuLng teLatLonAth
mLLeL haL Ltz handLeapA.

dLAtunce 05 1100

SLneeLeLu uouLL,

Max FLnk,
PMOKQLAOk

”.0.

04 PayehLatLq

�</text>
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                    <text>August 2, 1968
Dr. Ralph Smith

Mayo

Clinic

Rochester, Minnesota
Dear Dr. Smith:

For some time we have been carrying out

EEG

analysis

l800. The studies are primarily psycho~
pharmacological and we are now interested in adding EKG
analysis to determine the changes that may be associated
with high doses of psychoactive drugs.
using a

He

24K IBM

requested the assistance of

that a program for
at your Center. Is
documentation?
Many

EKG

it

IBM

and they indicated

analysis is available for the lane
possible to obtain the program and

thanks.
Sincerely yours.
Max Fink, M.D.
Professor of Psychiatry

MF:kp

its

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                    <text>August 5 . l968
Dr. McKeen

Cattell

Department of Pharmacology

Cornell University Medical College
l300 York Avenue

New

York. New York l002l

Dear Dr.

Cattell:

I have read and
and Hyams. and find

re-read the enclosed article

it

for publication in its

by Superman

too complex and unfocussed to be suitable
present form.

The authors approach two separate issues - a new mathematical
approach to the analysis of the integrated amplitude EEG. and the
effects of a novel agent. adrenochrome semicarbazone. The
evaluation of this compound is confused by the authors' interest
in the adrenochrome theory of schizophrenia and their observations

that the integrated EEG of schizophrenics is
reaction than like normal EEG.

much

The

article lacks clarity in the

effort could

I follow the

text.

more

like the

LSD

mathematics and only with
The

results presented are
is focussed on

only the mathematical data. but the discussion

the significance of the data for chronic schizophrenia. The
authors suggest that they have additional normal data (to be
published elsewhere) and use it in their argument. but we do
not have the opportunity to examine the data to learn its relevance
to a comparison with chronic schizophrenia (i.e., age, social class,
diet, previous drug history, educational level, etc, of the normal
population).

Finally. the authors fail to present any simple description
of the effects of the drug on the EEG. In view of the importance
of EEG changes for the effectscf psychoactive drugs, it is a
serious omission to find no simple quantitative description of
pattern and frequency effects, activation effects, egg, in an

article entitled as this one is.
I trust these comments are helpful.

Sincerely yours.

J/ézij7/J
nax Fi’nk,

no.

Professor of Psychiatry

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                    <text>August 5. 1968
Dr. Phi1iip H. Bookman
Department of Medicai Research
Hoffmann-La Roche, Inc.
Nut1ey. New Jersey 07110
Dear Dr. Bookman:
I regret that a satisfactory parentera1 form of R0 5-3350
does not exist, since we are embarking on a project in which
we wi11 have standards applicab1e to the anaiysis of this compound.

indicated during my visit, I am particu1er1y interested
in evaiuating new compounds in order to determine the popu1ation
of choice for c1inica1 efficacy. Perhaps when you or your
associates find another compound that is in the very eariy c1inica1
screening we may have an opportunity to review it with you.
As I

Sincere1y yours.

Fink. M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>August 6, 1968
Dr. Gaston~Germain Trigos

Wyeth Laboratories
Box 8299

Philadelphia, Pennsylvania

19101

Dear Dr. Trigos:

It was a pleasure to discuss studies of WT 3263 and WY 4036.
have had the opportunity to review the data submitted and
believe we can contribute to your study program.

we

4036. These initial reports of this novel compound
report anti-anxiety and anti-convulsant properties. Host unusual
is the report of annesic properties in patients.
NY

of

I reviewed the available

its

EEG

data, seeking a better definition

neurophysiology. Motor activity in mice was suppressed, with
WY 4036
being 100.200 x as effective as chlordiazepoxide. The EEG
activity in cats showed a "decreased frequency and further spindling"
at intravenous doses of l walks to 4 ng/kg. It is reported an
exceptional anticonvulsant, particularly against metrazole.
The clinical data reports ataxia and sedation during administration
of 5-10 mg/day oral, and nervousness, insomnia, diarrhea or constipation
two to three days after cessation of HY 6036.
Two studies are suggested in the population available in these
laboratories.

1. EEG Profile. As indicated, we find the EEG profile
in volunteers, supported by'similar data in patients useful in
classifying new psychoactive drugs, and identifying target populations.
If a parenteral form of WY 4036 is available, an EEG profile study
can be done rapidly, and a suggested protocol is enclosed.

If only

oral form is available, a similar study
it requires more extensive material and a longer
period of study. The protocol indicates the differences in
design in the supplement.
can be done but

an

�‘i

-2~

Dr. Trigos

Clinical

August 6, 1968

trial.

The anti-anxiety activity of
tested in a wide variety of anxiety
subjects. Our ongoing studies of anti—anxiety agents in a
mental health clinic population permit the introduction of
WY 4036 in either an
open study or a random comparison with
chlordissepoxide (our present standard).

2.

WY

4036 should properly be

I would also suggest that a study of the sedative
4036, especially its effects on the sleep EEG
("sleep—prints") be considered. The data cannot be collected
in my laboratories, but we are uniquely equipped to analyze data
recorded carefully elsewhere. The date can be collected in
collaborating laboratories, and if this is of interest, I will
be glad to provide the details.
effects of

WY

—

WY 3263.
The extensive trials already completed are clear
and the new efforts that may be necessary for a better delineation
of clinical applications may come best from the extensive clinical
trials when the iprindole is released. The data does not include
reports of EEG examinations. These would be useful to define the

neurophysiologic basis of the clinical response. In the face&lt;ftthe
extensive clinical data, perhaps such data would only satisfy outﬂw
scientific fancy.
An EEG

may yet be useful in completing the
be assessed in a fashion similar to
can
so,

profile study

submission, and

if

that suggested in the protocol for

WY

4036.

protocols are enclosed, for an EEG profile analysis and
WY 4036.
Protocols for a sleep-print EEG
WY
EEG
4036
and
of
an
study
profile of WY 3263 will be provided.
Two

a

clinical trial of
Thank you

material.

for the opportunity of reading this interesting
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Augwst 5,

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                    <text>August 6, 1968
Dr. Greenwell
Rowell Laboratories

Baudette,‘ﬁ!!tuu!!a
M '\ ﬁxing/5 ¢%c\

Dear Dr. Greenvell:

institution, we are interested in providing
for our students to treat manic patients with

As an academic

an opportunity

lithium carbonate and to observe

I contacted Dr. Charlea

its activity.

Shagaaa of Temple University who

that your laboratories can make lithium carbonate
available for trials and may assist us in filing an IND with
FDA.
informed

me

the

May I request a price list for lithium carbonate, and
permission to quote your manufacturing and other data in our
IND?

Thank you

for your cooperation.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 6, l968
Mrs . Carol Kahn

Medical World News
299 Park Avenue
New York, New York
Dear Mrs. Kahn:

is the reprint you requested. I am also sending
preprint of the very high dose fluphenazine study. If
this interests you it may also interest your readers, not only
as a statement of treatment efficacy, but also as an example
of the impact of present governmental regulations on American drug
We found it difficult to undertake these trials here
research.
and elected to carry out the study in Istanbul.
Enclosed

you a

He now have more extensive follow-up data and
more rewarding than the initial evaluations.

it is

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

even

�</text>
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                    <text>August 6. l968
Dr. Turen M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Turan,

Separately

I am sending you

five capies of the report

”Cyclezocine Classified as an Antidepressant by EEG
Criteria and its Clinical Trial". Following our discussions,
I am sending it to Dr. Bracelend for his consideration for the

Amentcan Jounnat 06 Psychiatny.

I am

believe that this report should have

not optimistic, but
exposure.

a wide

I am also enclosing a few copies of the companion report
reflecting the work in New York. I have asked Dr. Braceland

to consider both reports together.

Finally, I am enclosing a new review on EEG and drugs
which I have prepared for the Annuaz Review'oﬁ Phanmacology.
I trust
does Justice to your work.

it

I look forward

to seeing you on August 16.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>August 6, 1968

W

Dr. Greenwell
Howell Laboratories

Baudette,

MRAAQ‘CDO

Dear Dr. Greenwall:

K

As an academic institution, we are interested in providing
an opportunity for our students to treat manic patients with
lithium carbonate and to observe its activity.

I contacted Dr. Charles Shagsas of Temple University who
me that your laboratories can make lithium carbonate
available for trials and may assist us in filing'an IND with
informed

the

FDA.

May I request a price list for lithium carbonate, and
permission to quote your manufacturing and other data in our
IND?

Thank you

for your cooperation.
Sincerely yours,
Fink, 24.0.
Professor of Psychiatry

Max

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                    <text>"um..-”

V

.

r

"WWVWWV ~1nm-vvww-wt

r

“"‘».——v|"':-wv-

mwvwwm,

mmmv— .

August 6. l968
Hrs. Carol Kehn

Medical World News
299 Park Avenue
New York, New York
Dear Mrs. Kahn:

Enclosed is the reprint you requested. I am also sending
preprint of the very high dose fluphenazine study. If
this interests you it may also interest your readers. not only
as a statement of treatment efficacy, but also as an example
of the impact of present governmental regulations on American drug
We found it difficult to undertake these trials here
research.
and elected to carry out the study in Istanbul.

you a

now have more extensive follow-up data and
more rewarding than the initial evaluations.
We

it

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

is

even

�</text>
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                    <text>August a, 1968

M. Human S. 01me
Seated Rueaaeh Meaetate
Hagﬁmann-La Roche, Inc.
Nutleg,

New

0m Ma.

Jweg

07110

Weieman:

indicated, we aae going ahead with the analysts 06
the available data in one eunteal papulation aegaadtng high
doae Lébatum. Ae soon as that 14 available, I will bend you
AA 1

a copy

05 oua wry-mag.

15 you catch

mu available.

tabulaa

50am,

we «all be glad to make
planning to have the tnﬁaamatéan in

to have the data,
I

am

but t5

meow
we
membea to

eta“
Augguled outline.
I malt aequeet a

moae

Encloaed to a capy 05 a

Meme

aae 05
lateaeet,
pupa/Le these 50:10me yawn
a

lettu to De.

gully explain the goals 06

em

Goadan which may

laboaatoay.

Stnemely

yam ,

Fink, Md).
Paaéuaoa 05 Paychtamy

Max

�</text>
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                    <text>August 6. 1968
Dr. Lee Gordon
Hoffmann-La Roche. Inc.
Nutiey, New Jersey 07110
Dear Dr. Gordon:
Mr. Heisman was kind enough to approach us regarding a
high dose Librium study. As you may recognize such a study

does not stimu1ate much interest in the treating physicians
since they have a ready accepted high doses as a standard.
As this has been the first study that Hoffmann-La Roche has
recommended, I regret that we are unab1e to carry
out.

it

Some years ago I undertook phase 3 and phase 4 clinica1
eva1uation studies at Hi11side Hospita1. Nhi1e in Missouri
I found phase 2 and 1ate phase 1 studies of greater interest
and deve10ped, in conjunction with my associates. Drs. Iti1
and Shapiro, a method of EEG anaiysis which we fee1 contributes
to our understanding of the mode of action and target popuiations
for new psychoactive drugs. I am taking the 1iberty of enc1osing
a copy of a review of EEG and drug effects which I prepared for
the ACNP in 1967.

are particuiar1y interested in phase 2 and 1ate phase 1
studies, especia11y those which permit us to utiiize our EEG
mode1. The faci1ities for new drug eva1uation in this Department
are extensive and inc1ude two EEG 1aboratories and a computer
faciiity, a 25 bed in-patient unit for narcotic addicts and
psychotic patients, a 1arge menta1 hea1th c1inic servicing a
wide variety of popu1ations, and 1ate1y a speciai out-patient
unit for chiidren and ldo1escents. It might be useful for you
or some of your associates to visit our faci1ities in order to
obtain an appreciation of the opportunities which they represent.
We

Sincere1y yours,

Max

Fink,

M.D.

Professor of Psychiatry

Mszp
cc:

Mr. H. Heisman

�</text>
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                    <text>August 7. 1968
Dr. Turan H.

Itii

Missouri Institute of Psychiatry
5400 Arsenai Street
St. Louis, Missouri 63139
Dear Turan,

Enciosed is a draft of the paper by Drs. Schwartz and Feidstein.
the tapes have been analyzed but these were not completed
before Dr. Schwartz went on vacation. I expect him to return
in September, since he is in Engiand. At that time I hope he
will go over the material and rewrite this report inciuding
an outline of the next important steps.
A11

My

best regards.
Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>August 7. 1968
Dr.

J.

F. Remarque. Vice President

Elsevier Publishing

Company

P. O. Box 2ll
Amsterdam. The Netherlands
Dear Dr. Remarque:

Please send me ten additional cooies of Antichoﬁinexgic
ﬂange, Volume 28. Pnogaeob in Baain Reaeanch and bill me
accordingly.

Thank you very much

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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“

w-

w.n~w.r—-~ntr-v.-r-u .. ...
,

.

w.

"my... ‘_

1r»wr:t-

_

.

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. ..., '-W-

F5.

August 8. 1968
Dr. G. B. Biane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons, Ltd.

Huii, Engiand

Dear Dr. Biane:
For the past two years we have studied the conditioning
theory of narcotic addiction as expressed by Wikier. We started
with cyciazocine and carried out some studies with naioxone.

Cyciazocine has the disadvantages of a narrow therapeutic
index and naioxone appears to have a very short duration of
action. Despite these iimitations, both treatments appear to
foiiow the deconditioning modei and have shown sufficient promise
to excite us to continue. We are interested, however, in any

other narcotic antagonists

which can be of longer duration of

action and with fewer side effects.
I am

enciosing copies of our reports which wiii bring you

up—to-date in our present program.
.

In the event that SOSO-M, or other active antagonists
goes to human triai, we wouid be anxious to test it.

Sincerely yours,

~_v,ww..wnv,_

Fink, M.D.
Professor of Psychiatry

Max

mmﬂwmuvm.mwﬁlwvmww

.m

.
.~

Mszp

v—

m

W»

W

~

.

�</text>
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August

8,

1968

Dr. Norman Neiss
Chairman, Program Committee

Queens County Psychiatric Society
109-10 Queens Bivd.

Forest Hiiis,

New

York 11375

Dear Dr. Weiss:

pieased to speak to the Queens County
The two dates you have selected,
December 10 and i7 occur at a time of the year when I
am away for meetings.
I wouid be

Psychiatric Society.
I can make a

approximateiy the

lecture in

same

time.

November

or January at

Perhaps the best would be for you to call
afternoon
at (212) 369-7900 Ext. 245.
any

my

office

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszp

"~-

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                    <text>v... &lt;.—. mn-

».«—

-

—,

.

..

_

4...,"

.--————~~. ~r-a—~ «ivy—v

”WM—v—wr."m~.~-yw vgrww-v—

.

V—w

"‘3".an

a...“ urc'

»

murmur-‘7' m

“Wt‘V'rr—r‘wvz' "up

August 8, 1968
Dr. Norman Weiss

Chairman, Program Committee

Queens County Psychiatric Society
109-10 Queens B1vd.
Forest H1113, New York 11375
Dear Dr. Weiss:

to speak to the Queens County
The two dates you have se1ected,

I wou1d be p1eased

Psychiatric Society.

December 10 and 17 occur
am

away

for meetings.

I can make a

at

1ecture in

approximate1y the same time.

a time

of the year

November

when I

or January at

Perhaps the best wou1d be for you to ca11
at (212) 369-7900 Ext. 245.

any afternoon

my

office

Sincere1y yours,

Fink, M.D.
Professor of Psychiatry
Max

Mszp

._. .w--

'1"

"rev-w”

I'u—‘llet'Y—rrWVV

w.”-

-..-v

�</text>
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                    <text>August 9, 1968
Ma. 1. w. Kuntz, la.
The Blue Line Chemical Company

302 South Enoadway

St.

LouiA, Mibbouni 63102

Dean Mn. Kuhtz:

Thank gnu veny much 604 youn pnompt and most uAe5u£ nepﬂy.

I do not know how we miéaed théb item not how the phanmaciat
did, but we axe abze to obtain the amputea 5aom E££ titty and
thia udlz indeed make can paoject ﬁeaaibte.
Many

thanké 50a youa heﬁp.

Sinceaeiy
Max

Fink,

younA,

M.U.

Pnoéebaqa 05 Péychéatag
MF:kp

�</text>
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                    <text>a, new. a—
-

August 16, l968
Dr. Jonathan 0. Cole

Superintendent
Boston State Hospital

Boston, Massachusetts 02l24
Dear Jon,

Enclosed are the initial reports on cyclazocine as
an antidepressant as submitted for publication to Dr. Braceland.
This suggestive confirmation of the EEG predictor model for
psychoactive drugs has stimulated ongoing studies of doxepinc.
Al

Perhaps you

DiMascio.
My

may

wish to share these reports with

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>2.:

.—

a—vv

1117",“.

'r

».--

v

.

my

-

(«up

-

s

,

..~v--~-- I‘w

..

'rvrn-

,

--—

--.-w-

..

A»

var,

-

~-.-

-...-.-..«

7

m

August 19, 1968
Dr. Seymour Kety

Massachusetts General Hospital
Boston, Massachusetts 02114
Dear Seymour,

told me of your interest in our eXperiences with
cyclazocine as an antidepressant as well as an anti-narcotic.
Enclosed are two reports as submitted for publication. They
lack the necessary controls and are only suggestive as they
stand. Derived from the EEG-behavioral model, these experiences
support the need for further trials of the EEG model, and for
cyclazocine, the need for independent controlled clinical trials.
Al

My

best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

�</text>
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                    <text>August 19, 1968

Dr. Stratton
Grune and

Stretton

381 Park Avenue South

New

York,

Dear Dr.

New

York

Stratton:

For more than a decade I have studied convulsive therapy, psychopharmacology and electroencephalography. During the past year, I prepared
a series of seminars in psychopharmscology viewing this discipline from a
neurophysiological and experimental point of view. The seminars were well
received and I now have the staff response in addition to the notes.

is a suggested outline of a volume which I
write with either of the following suggested titles:
Enclosed

An

would

like to

Psychopharmacology
Experimental (or Neurophysiological) View

I will project the volume for psychiatrists, experimental psychologists,
clinical neurologists. The focus will be on the variety of
psychoactive drugs of the last two decades. It will include the latest
experimental data from computer, EEG, psychophysiology and sleep laboratories.
and perhaps

Each chapter will be between 15 and 20 double spaced type~written
pages. The number of citations will be extensive, probably averaging
forty for each chapter, but should not exceed 400 for the volume. You

may know

that I have already edited the Bibliogkaphy

Paychophwrmozogy (Etwowenceph.

can.

Eleevier) and recently, Anticholinaﬂgic

Animu£4 and Man (Pnogkebb

P. Bradley).

I believe such a
you.

If

such a venture

in

Nwoyohyaiot. , Supplement 23,

Unugé and Bkain Functiona

Benin Reéeatch, 28,

volume can be prepared

interests you, I

06 EEG and Human

Elsevier,

in 9-12 months.

would be pleased

to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

in

1968, with

meet with

�</text>
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                    <text>August 19 , 1968
Mr.

Earl Ubell

“CBS—TV

518 West 57th

New

York,

Dear

Street

York

Earl,
For some time I have been interested in writing a book on the

E

‘

New

relation of drugs, EEG and behavior and would like to undertake this
mission this“ fall. I recognize that while the content of my writing
is scientifically accurate, its style is poor and needsthe assistance
of someone capable of handling scientific writing with clarity as the
principal objective. Can you recommend, or would you inquire of your
brother or friends for someone who might assist me in preparing a
better presentation this winter?

;
i

;

Laboratories made naloxone available and the
Public Health Service, tetrahydrocannabinol, both on the same
day last week, so that we are able to undertake these studies after

U. 8.

Incidentally

ENDO

Labor Day 0

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August 19, 1968
Dr.

J. F.

Remarque, Vice President

Elsevier Publishing

P. O. Box 211

Company

Amsterdam, The Netherlands
Dear Dr. Remerque:

For more than a decade I have studied convulsive therapy, psycho—
pharnacology and electroencephalography. During the past year, I prepared
a series of seminars in peychopharmecology viewing this discipline from a
neurophysiological and experimental point of view. The seminars were well
received and I now have the staff response in addition to the notes.

is a suggested outline of a volume which I would like to
with
write
either of the following suggested titles:
Enclosed

An

Psychopharmacology
Experimental (or Neurophysiological) View

I will project the volume for psychiatrists, experimental psychologists.
clinical neurologists. The focus will be on the variety of
psychoactive drugs of the last two decades. It will include the latest
experimental data from computer, EEG, psychophyeiology and sleep laboratories.

and perhaps

Each chapter will be between 15 and 20 double spaced type~written
pages. The number of citations will be extensive, probably averaging
forty for each chapter, but should not exceed 400 for the volume.

I believe such a

If

contact

such e venture

me.

volume can be prepared

interests you, I

in 9-12 months.

would be pleased

ti

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkp

you would

�</text>
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                    <text>August

l9, l968

Dr. Nathan S. Kline

Director of Research
Rockland State Hoseital

Orangeburg.

New

York

Dear Hate.

It

has taken many years to develop a usable

EEG

predictor

novel psychoactive drugs. The enclosed reports of
cyclazocine as an antidepressant have been submitted for
publication. Knowing of“your interest and enthusiasm for new

for

model

drug evaluations. perhaps these experiences may suggest similar
experiments with other novel compounds.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August

l9, l968

Dr. William Tabor

A. H. Robins Company
l407 Cummings Drive
Richmond 20, Virginia

Dear

Bill.

pleased to enclose our second interim report in our
analysis of the fenfluramine. amobarbital. dextroamphetamine
EEG study.
After an hiatus of many months. we have been able
to get back to this analysis and find that the results, regardless
of which technique of analysis we use, are the same. Fenfluramine
is most distinguishable from amphetamine and least from 50 mg
I am

amobarbital.

are anxious to report this material in the scientific
press and will do so shortly. In the interim, however. you
may feel free to make conies and distribute these within
A. H. Robins or for any governmental submissions which you
may feel necessary.
We

In addition to this report I am enclosing individual case
records of the volunteer subjects in the fenfluramine EEG study.
While in St. Louis on Friday, I discussed the individual case
records of the fenfluramine reaction time subjects with Dr. Itil.
I gave him the forms and he assured me that a member of his staff
would complete them on Monday or Tuesday at the latest and send
them directly to you. Since he felt that he could accomplish the
mission without any assistance from me, I trust this is satisfactory.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc .

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                    <text>August

l9,

1968

Dr. Jerome Levine

Psychopharmacology Research Branch

national Institute of dental Health
5454 Wisconsin

Chevy Chase, Maryland

Dear
on

Jerry,

draft copies of recently completed reports
the antidepressant qualities of cyclazocine. were it not
Enclosed are

for the neurophysioloqic data I would hesitate to report such
uncontrolled studies. Perhaps the studies now in progress may
confirm the View and lend some additional Inpport for the EEGbehavioral association model.
for the THC. He will begin the
I am also pleased to tell you
and the clinical studies are
in
naloxone
supply
is again
that
many thanks
summer recess.

Incidentally,

study after the

again in progress.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August 19, 1968
Dr. Heinz E. Lehmann

Ciinicai Director

Dougias Hospitai
6875 Lasaiie Blvd.
Verdun. Quebec,
Canada
Dear Heinz,

It

has taken many years to deveiop a asabie EEG predictor
for novei psychoactive drugs. The enciosed reports of
cyciazocine as an antidepressant have been submitted for
pubiication. Knowing of your intereSt and enthusiasm for new
drug evaiuations, perhaps these experiences may suggest simiiar
experiments with other novei compounds.

model

My

best regards.
Sincerely yours,
Max

Fink, M.B.

Professor of Psychiatry

�</text>
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                    <text>'
r

‘
'

'

August 19, 1968
Dr. Seymour Kety

Massachusetts General Hospital
Boston, Massachusetts 02ll4
Dear Seymour,

of your interest in our experiences with

Al

told

My

best regards.

me

cyclazocine as an antidepressant as well as an anti-narcotic.
Enclosed are two reports as submitted for publication. They
lack the necessary controls and are only suggestive as they
stand. Derived from the EEG-behavioral model, these experiences
support the need for further trials of the EEG model, and for
cyclazocine, the need for independent controlled clinical trials.

KHFXIWHF’”!

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

�</text>
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                    <text>August 19, l968
Dr. Allen Raskin
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland

,

Dear Allen,

Enclosed are the initial reports on cyclazocine as an
antidepressant as submitted for publication. I trust these
meet your expectations. Dr. Bird has called to say that he

plans to hold

a meeting

in late September.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF2kp

�</text>
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                    <text>August 20, l968

Felix Morrow
l0 Old Colony Lane

Mr.

Great Neck,
Dear

New

York

Felix,

pleased to enclose a copy of an outline of a
called either "Lectures in Psychopharmacology“,
"Psychopharmecology. A Neurophysiologic View" or just
"Psychopharmacology." In addition I am enclosing two reports
which form the basis of two of the chapters. A third report
is enclosed to give you a view of the general field.
I am

volume to be

I would be grateful
proper way to present in
My

for your suggestions regarding the
writing such a volume.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Mex

Mszp

�</text>
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                    <text>August 20, 1968

Librarian
New

2

York Academy of Medicine

East 103rd Street

New

York,

Mew

York

Dear Madam:
I wouId be gratefu1 if you wouId permit Dr. Rhea Dornbush
to work in the Iibrary during the hours open to Fe110ws as she

is working

If

on a

project for

me.

it necessary to take out books and journaIS.
her doing so.

she finds

I wouid approve

Sincerer yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 22, 1968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

I very much enjoyed my visit and have completed some
of the things on my agenda. Grass Instrument will ship two
amplifiers and they should arrive early next week.
Dr. Barry is coming to visit on Friday, August 231 He
does not need a protocol but suggests that we take care of the
full filing with the FDA ourselves. As soon as I have an IND
number, he will ship the supplies of fluphenazine.

I have already dictated a letter to Sidney Merlin
for Fellowship in the ACNP.

recommending you

Enclosed are the bills for some of the computer time at
the College. The lab scale ~ psychopharmacology bills represent
one—half the costs to date. It would be most helpful if payment
for these charges can be made to "Division of Biomedical
Information Processing ~ New York Medical College“ and sent
to Dr. Donald Shapiro at 5 East 102nd Street, New York. New York 10029.

I
My

am

also enclosing a statement for

my

visit that is appropriate.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 22, 1968
Dr. Sidney Merlin

Central Islip State Hospital
Central Islip, New York

Dear Sid,

I

am

writing to recommend a promotion of
to Fellow of the ACNP.

from Member
Dr.

Dr. Turan

M.

Itil

has been a leading worker in the field of psychoItiland
electroencephalography since 1955. Since joining

pharmacology
the Missouri

Institute of Psychiatry in

unusually
active in establishing new drug evaluation programs, experimental
studies in schizophrenia, and continued his interest in EEG. He
has been most productive and has published more than 30 articles
from the Institute alone.
1963 he has been

has been an active member of the ACNP and has attended
every meeting. He has been Co-Chairman of the Section on
Neurophysiology for the past two years and was elected to this
He

position

by the members of

that panel.

his university he has been promoted from associate
professor to full professor and has been named Assistant Chairman
At

of the Department.

In view of his particular interest and enthusiasm for psycho—
pharmacology, his active participation in the College, and in
recognition of his many contributions, I am pleased to recommend
him for Fellowship.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

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                    <text>August 29 , 1968
Dr. Hanns Hippius

Direktor der Psychiatrischen Klinik
Preie Universitat Berlin

II

Nussbamralle 36

1 Berlin 19 Germany

Dear Dr. Hippius:

I am pleased to send you copies of our report on cyclazocine
in the treatment of narcotic addiction as well as preprints of
the use of this drug in the treatment of depression. As I
mentioned to you in Spain, we came upon the use of cyclazocine
as an antidepressant from its m profile. The data is described
in these two reports. Of course, further study is necessary and
I hope that others will make the necessary independent investigations.
My

best regards .
Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

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                    <text>August 30, 1968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

that we have not sent you samples of the
data
output. I was waiting for xerox copies of the
laboratory
but
these will not be available for a few more days.
full set,
In the meantime, enclosed are sample sets from one of our analyses.
Don

reminded me

The laboratory standards are our standards and your reports
will, of course. have a similar set with your standards listed.
Where
states New York Medical College, we will list MIP.

it

Each individual sheet is a single report from a single optical
scan sheet. The age, sex, date. drug and dosage were keypunched
separately from lists supplied by my staff. In the new forms
this data will come directly from the form. The third type of
output is a listing of all the tests for each patient and this
is derived directly from the individual sheets (you will note
that these do not have drug or dosage listed for each date and
this will be corrected in the new forms).

are able to handle the MIP-PLD forms and provide you
with these outputs. To do so would require the forms and a
clear statement on the head of each form of the mate. drug,
dosage, age and sex of the subjects.
We

can provide outputs for your present forms
be able for the new forms within two months.
We

now

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

and should

�</text>
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                    <text>June 6, 1968
Dr. Joseph 6. Bird
Sterling Winthrop Research

Rensselaer,

New

York

l2l44

Institute

Dear Joe.

Separately

I am sending you complete data folders and
patients who received cyclazocine in the
cyclazocine-depression study at the New York Medical College

summaries of 19

and Nos. 072-098 of

patients receiving cyclazocine in the
treatment of narcotic addiction. I trust this data is helpful.
Thank you

studies.

for your assistance in carrying out these
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 6, 1968
Dr. E. R. Gabrieli

Director, Clinical Information Center
University of Buffalo
Buffalo,

New York

Dear Dr.

Gabrieli:

letter in the

J.A.H.A. In this medical school,
of the activity is in the ﬁepartment of Psychiatry and we
are involved in developing a coordinated data processing system
for psychiatric data. He would like to send a representative
toyyour meeting. Would you please put us on your mailing list
for any announcements?

much

I saw your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>June 6, l968
Dr. Roger Meyer

Acting Director

Center for
NIMH

Drug Abuse

5454 Wisconsin
Chely Chase, Maryland
Dear Roger,

is a from I have just received from Dr. Scigliano.
It seems to that a submission of this kind is more extensive
than any submission I have had to make for any drug since I
became interested in this problem in 1952. The submission is
Enclosed

me

I have had to make for such hallucinogens
as Ditran and. more recently. heroin.

also greater than

patiently cooperated with various
May l967 and can now fully undersince
governmental agencies
amount
why
stand
of marijuana research has been so limited.
the
In the event that you can assist me in obtaining supplies of
THC or marijuana without once again going through these formalities.
As

you know. I have

grateful.
feel that it is mandatory that

I would be most
Do

you

unhealthy procedure?

we

follow this

Sincerely yours,
Fink, “.0.
Professor of Psychiatry

Max

MF:kp

cc:

Dr.

J. Levine

�</text>
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                    <text>June 6, l968
Dr. Jack H. Mendelson

National Institutes of Mental Health
Alcoholic Research Center
5454 Wisconsin
Chevy Chase. Maryland
Dear Jack,
As I mentioned, I am writing a review of the EEG changes
with psychoactive drugs for the Annuaz Review'og Phanmaeology.
like to include a summary for the recent studies with
IINggl?
o

a c

that

.

I would be grateful for any
I can check against my own.

from your files
Thank you very much.

citations

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>June 6. 1968

Ziering, R.N.
Psychiatric Instructor

Miss Hannah

The Englewood Hospital Association
Englewood. New Jersey 0763l
Dear Miss Ziering:
would be pleased to have you and your students visit us
and because Thursday is the best day for part of the demonstration,
I suggest you come on June 27 and August 8.
We

The core demonstration would be a case conference held on
Thursday from 10:30 am to 12:00 noon on ward l2. If you can
arrive at 9:30 am. I will arrange for a tour prior to the
conference. From 12:00 to l:00 we will arrange for one of the
nurses who would eXplain the nursing aspects of patient's care

in these units.

tell us the number of persons coming. I will aSk to
for
to have lunch and after this you will meet with
you
arrange
one of our physicians and a member of the rehabilitation team.
A good overview can be obtained by 3 o'clock.
If time is short,
If

you

then we would suggest that you not attend the conference and
can arrange for discussions from 9:30 to l2:00.

we

I will arrange for our psychiatric assistants to be with
you throughout the day and they will provide a continuing conmentary.

it

As I discussed with you on the phone,
would be most helpful
I could provide the psychiatric assistants with an honorarium
for their time and I would suggest that the Englewood Hospital
Association sen&lt;1two checks in the amount of $50.00 each in the
name of Manuel Rodriguez and Albert Hassan. Please send the checks

if

to

my

office.

Please confirm

if

the dates and times are satisfactory.
Sincerely yours.
Fink. M.0.
Professor of Psychiatry

Max

�</text>
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                    <text>June 6, l968
Dr. Burtrum C. Schiele

Professor of Psychiatry

Department of Psychiatry and Neurology
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dear Burt,
I have just spoken to Joe Bird and since no meeting of
the investigators of cyclazocine is being planned for June,
I am suggesting that perhaps we can get togehter during the
ECDEU meetings on June 24-25.
In the meantime I am enclosing
the prepublication copies of the two reports from this and
Dr. Itil's laboratory which will be completed in the next few
weeks and sent to a psychiatric journal.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

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                    <text>June 6, l968
Mr. Earl Ubell
CBS News

51
New

Nest 52nd Street
York, New York

Earl,

Dear

If you want to know
limited in this country.
enclosed documents which

why research in marijuana is
I would suggest you read the
I have Just received from the

far exceeds any requirement of the
Administration with which I have had to
comply for any drug since l952. including hallucinogens
and heroin.
This procedure

NIMH.

Food and Drug

My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp
enc .

�</text>
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                    <text>June 6. 1968
Mr. Donald Cheetham

Smith Kline and French Laboratories
l500 Spring Garden Street

Philadelphia, Pennsylvania
Dear Don.

As I indicated in my previous letter, one of our
associates is interested in undertaking a study of parnate
.

and chlorpromazine in the treatment of anergic schizophrenic
patients. Enclosed is a c0py of the protocol.
I would be grateful if Smith Kline and French could
available supplies of parnate and parnate placebo
for this study. If so, I would appreciate an initial
supply of lOOO mg tablets and 500 identical placebo tablets.

make

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

�</text>
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                    <text>June 10. l968
Dr. John C. Kramer

Chief of Medical Research
Department of Corrections

California Rehabilitation Center

P. O. Box

l4l

Corona. California
Dear John,

Rockefeller Meeting on June Zl~22 has the aura of
religious conversion performance. I will probably ask a
member of my staff to attend on Saturday morning to see
if
the results have dropped below 97% success.
The

a

Saturdays in June are beautiful in

will probably find
How

me on

about coming out?
My

best to

New

York and you

the tennis courts in Great Neck.

Supper?

Deena.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June
_

l1,

1968

Mr. Hayes A. Dorr

Coordinator, Special Projects
Institute for Scientific Information

Street
Philadelphia, Pennsylvania
325 Chestnut

19106

Dear Mr. Barr:

for your letters regarding the ASCA III Program.
I believe a trial subscription might be useful and I am
enclosing two pages of profile entries which follow your
model. If I am correct. the six items listed as
suggested
lA and eight items as 1A3 should result in citations if one
word or stem from any 2 of the 3 groups is cited. Thus EEG,
Period Anal; or Computer/Drug; or Electroenceph/Psychot will
Thank you

result in

citation.
Similarly, any articles citing Adey's article in ﬁngerimental
Neurolggy will be listed.
a

If these

correct. I
suggested charge for this service for one year.
two understandings are

would 1ike a

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

�</text>
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Dr. Thomas Williams

National Institutes of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Dr. Williams:

Enclosed is a copy of the HEW Indirect Cost Statement,
dated June 4, for the International Association for Psychiatric
Research, Inc.
Thank you

for your cooperation.
Sincerely yours,
Max

Mszp

Fink,

M.D.

�</text>
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                    <text>June 6, l968
Dr. Burtrum C. Schiele
Professor of Psychiatry
Department of Psychiatry and Neurology
University of Minnesota Medical School

Minneapolis, Minnesota 55455
Dear Burt,

I have Just spoken to Joe Bird and since no meeting of
the investigators of cyclazocine is being planned for June,
I am suggesting that perhaps we can get togehter during the
ECDEU meetings on June 24-25.
In the meantime I am enclosing
the prepublication copies of the two reports from this and
Dr. Itil's laboratory which will be completed in the next few
weeks and sent to a psychiatric Journal.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>June l3, l968

Librarian

York Academy of Medicine
East l03rd Street

New

2

New

York,

New

York

Dear Madam:
I would be grateful if you would permit Dr. Robert Levine
to work in the library during the hours open to Fellows as he

is working

on a

If he finds
his doing so.

project for

it

me.

necessary to take books out,

I would approve

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                  <elementText elementTextId="102629">
                    <text>June 17, 1968
Dr. Martin Hallidsy

National Hospital

Queens Square
London, England

Dear Dr. Halliday:

'

Dr. Charles Shagass, who

laboratories.

recently visited your

discussing your program of research
in convulsive therapy and indicated that you had made
some novel observations on differences in memory
function with the unilateral and bilateral treatments.
We are studying this problem and
your experiences may
be most helpful. for Dr. Shagass indicates that different
memory tasks yielded differences in results for seizures
on the dominant and non-dominant sides.
was

If these reports are indeed correct. I would be
grateful for a preprint of your report; or if
published. the citation or reprint.

most

Thank you very much and my

congratulations on

having made such a forceful impression on

friend.

my

good

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>June 17. 1968
Dr. Stanley P. Yolles

Executive Director

National Institutes of Health
5454 Wisconsin
Chevy Chase. Maryland

Dear Dr. Yolles:

I want to

talks. both in

tell

New

you how much I enjoyed the

York and Washington.

I discussed with you. I am enclosing a
copy of the present marijuana procurement procedures
as sent to me by Dr. John A. Scigliano. While we
will attempt to comply with these requirements. I
think it would be useful to make the procedures
lees onerous. Surely. marijuana and THC cannot
be so dengerous that the procedures should be
significantly different than the testing of
investigational drugs.
As

assistance you can give to make marijuana
institution
or THC available for stucy at this(EEG
MH-13358
and Human
under our present grant
Any

Psychopharmacology)

will

be appreciated.

Sincerely yours.
Max

Fink.

14.1).

Professor of Psychiatry

Hakp

�</text>
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                  <elementText elementTextId="102627">
                    <text>June 17. 1967
Dr.

Fletcher

Owens

A. H. Robins Conpany
1407 Cummings Drive
Richmond 20, Virginia

Dear Dr. Owens:

I

am

writing to bring to your attention a

small problem with capsules of Tybatran. During
the last two weeks. When the weather has been
unusually hot. the capsules have developed a
gelatinous softening and the surface has changed
from being smooth to one that is grossly irregular.
On occasion the capsules have stuck togethsr.
This occurred in our clinic, but also to
two of our patients who insisted that the capsules
had been kept in their pockets.
The nurses have brought this to my attention
with a question as to whether tho capsules ought
to be kept refrigerated.
My

best regards.
Sincerely yours.
Max

Fink. NJ).

Professor of Psychiatry

Wdtp

�</text>
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                  <elementText elementTextId="102626">
                    <text>June 17. 1968
Executive Secretary
Marihuana Advisory committee
Center for Studies of Narcotic and
Drug Abuse

National Institute of Mental Health
USPHS~BHEW

5454 Wisconsin Avenue
Chevy Chase. Maryland 20203

Dear

Sir:

Enclosed are twenty~£ive copies of the documents
which you have requested in order to provide us with
supplies of marihuana and tetrahydrocannabinol for

investigational purposes.
1a)

b)
c)
d)

See protocol attached
See curriculum vitae
See protocol
Baa

~
~

Exhibit
Exhibit

1
2

protocol

For marihuana trial: we will require approximately
one ounce for every ten experiments and would like to request
four ounces an an initial aupply.
2)

is

For tetrahydrocannabinol we understand that 20

an average dose and
3)

for

20

trials

we would

roquiro

Both marihuana and tetrahydrocannabinol

stored in an approved narcotic safe at
Eighth Floor.

Room 42A.

recommendations.

Documentation

is

4)

Curriculum vitae

5)

Institutional setting:
a)

5

East

will be
Street,

102nd

will follow your

oncloaad.

Department of Paychia try. new York medical
College and Hetropolitan Hospital Medical

Center.

mg

400 mg.

�b)

This project has been approved by the
Chairman of the Depertoent of Psychiatry.
the Research Committee of the New York
Medical College-Metropolitan Hospital
Medical Center and the Commissioner of
Hospitals of the city of new York.
See letter. marked Exhibit 3. 4 and 5.

6o)

b)
3;

IHD 4724

-

EXhibit 6

See Exhibit 5 - Letter from Rosearch Committee.
Consent form ettedhed ~ Exhibit 7.
Merihuene Tax Stomp ~ Exhibit 8.

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

Wakp

enclosures

�</text>
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                  <elementText elementTextId="102625">
                    <text>June 17. 1968
Dr. martin Halliday

National Hospital

Queens Square

London. England
Dear Dr. Hellidey:

recently visited your
laboratories. was diacuaeing your program of research
in convulsive therapy and indicated that you had made
some novel observations on differences in memory
Dr. Charles Shagaee. who

function with the unilateral and bilateral treatments.
are studying this prdblem and your experiences may

we

helpful. for Dr. Shagaee indicate: that different
memory tasks yielded differences in results for seizures
on the dominant and non~doninant sides.

he moat

If these reports are

indeed correct. I would be

grateful for e preprint of your report: or
published. the citation or reprint.

most

Thank you

very

much and my

it

congratulationn on

having made such a forceful impraeeion on

friend.

my good

Sincerely yours.
Max

Fink. u.D.

Professor of Paychiatry

Hakp

�</text>
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                    <text>June 17, 1968
Dr. William Triebel
Gracie Square Hospital
420 East 76th Street
New

York,

Dear Dr.

New

York

Triebel:

I would be pleased if you would consider the appointment
of the following members of the staff of the Department of
Psychiatry of the New York Medical College to the staff of
Gracie Square Hospital.

Research Psychiatrist
Research Psychiatrist
Research Psychiatrist

Richard Abrams, M.D.
Robert Levine, M.D.

Michael Taylor, M.D.
Alfred Bruner, Ph.D.

Electroencephalographer
Psychologist

Rhea Dornbush, Ph.D.

Patricia Landis
June Horwitz

Research Nurse
Research Nurse
Research Assistant
EEG Technician
EEG Technician
EEG Technician

Phyllis Karliner

Suzanne Kraft
Pauline DaCosta

Constance Martane
Kathleen Pelczynski

Secretary

While I do not expect each of these people to be at Gracie
Square at the same time. they are all participating and should

feel that they are included in the Gracie Square Family.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>June 19. 1968

Professor

Hex Hamilton

Department of Psychiatry
The University of Leeds

ls

Hyde

Terrace

Leeds 2. England

96‘!

Max.

I have received a telephone call from Nathan
for

if

I had room in my laboratory
Hamilton's by the name of John
a disciple of
Nicholas Hall. Of course. I said yes. When I
is
called George Simpson he told me that ur. Hallcoming
in
who
is interested
a clinical psychologist

Kline asking an

Max

for three months.

I have missed talking to you over the past few
years. but I have not remained idle. This laboratory
has an in-patient and outvpatient component focussed
at
on narcotic addicts and psychotic-z a study in ECTEEG
for
a large private hospital: a computer facility
analysis and other data processing: and assorted
psychologists. residents. 25g.
If ur. Hall is interested in working in the kind

of a show that I had at Hillside. but immeasurably better.
is one problem
I would be pleased to consider him. Thereand
with
if not from
which I would like to have some help
have
we
him. perhaps from one of your other sorters.
been using the Hamilton Rating Scale and have written a
kinds of depression
seall program to classify differentitems
of historical
seven
adding
from that scale after
of
depressives.
information. I have a large population
(we
fun 50
both before and during convulsive therapy
treatments a day). at this point I would be interested

�d

Professor Hamilton

—2—

June 19. 1968

in having codibody work with my residents in the
proper application of the scale and in exploring
its diagnostic and even some of its predictive
features. surely. I would not restrict the work
to this scale elone. but would be pleated to use
some other measures.

tell: no that Mr. Hall would like to
in
curly
July for three months. I think three
months is somewhat short. especially over the summer.
but I would be glad to entertain him for that period
if you think it would he mutuelly useful.
The next time you wish to send someone. perhaps
you would think of no.
my best personal regards.
come

George

Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

MF:KP

�</text>
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                    <text>Jane 19. 1968
Dr. Roland R. nonato and
Dr. William Guy
George Washington university
Room

1145

Bionstrio Laboratory

618

Nineteenth Street. H.w.

washington. 0.6. 20036
Dssr Ron and Bill.

I want to thank you for the data outputs and
tho
for
tins you spent with no on Friday. I discussed

tha outputs with my associates and we are pleased with
the nothods of presentation. I pointed out that we
were missing the drug-dose data and these forms ars
bsing completed now.
Enclosed ars two cepies of the laboratory report

which describes the standards

in plscsbo traatod patients

during my stay in Missouri. I think this is an important
nodal for all drug studies.

I look forward to seeing you

Monday.

Sincerely yours,
Max

Fink. M.D.

Professor of Psyohiatry

nfzkp

�</text>
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                    <text>June 20. 1968
Dr. Joseph

wertis. Chairman

Editor of 1967 Transactions
152 Hicks

Brooklyn,

Street
New

York

Dear Joe.

Enclosed is a draft copy of our article from
the meeting on Saturday in washington.
Dr. White

will

be spending the next year in

the laboratory of Dr. Phillip Bradley in Birmingham.
the galleye are available it would be useful if
you would send me a set for you may get them quicker.

When

My

best regards.
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>Juno 21. 1968
Dr. Henry

Brill

Narcotic Control Commission
1855 Broadway

Haw

York.

New York

Dear Henry.

Enclosed is another chapter in the saga of
cyclazocine. This study was done in Tanneasee
with can» assistance from us. I think it will

interact

.

you.

I want to thank you once again for sanding
Miran
Dr.
was a most interesting
to no. for
visit and 1 hop. that something can bu workcd
out in colldboration with him.

it

My

best rogards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Wtkp

�</text>
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                    <text>June 21. 1968
Dr. Jerome Levine

Peychophernecology Research Branch
National Institutes of Mental Health
5454 Wieconein
Chevy Chase, Maryland

Deer

Jerry.

is

draft

copy of a pharmacological
undertaken
by Dr. Richard White
study of cyclezocine
and
supported by
of the university of Tennessee

Enclosed

a

Dr. White found thet cyclezocine we:
indeed like imipreminc in its pharmacological profile
and I em planned that the reunite parallel our clinical

HH~12567.

experiences.

Many Ebenke

for the support of van in this study.
Sincerely yours,
Hex

Fink. n.D.

-

Protease: of Psychiatry

MFskp

enclosure

�</text>
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                    <text>June 21. 1968
Dr. E. B. 5199
Geigy Pharmaceuticals

Ardeley.

New York

Dear Dr. 3199:

Enclosed is a report recently presented at

the Society of Biological Psychiatry. Dr. White
has requested that we send you a cepy as he has
just left for England. He wishes to thank you for
your cooPeration.
Sincerely yourl.
Mex

Profeseor of Psychiatry

,
R,

Jr.

U,
,5

Mszp

,

'tV.“w-I

a,
.A

u

r
|

”s
A»

nr

my.qz,vym-v1;,q

HQ:

ﬁr“):

mqvm-w-

mr—mmwm

(ATFWWTVH'I‘WLVWH

wruﬁgh‘w-

up

Fink. H.D.

enclosure

�</text>
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                    <text>Jana 21. 1968
Dr. William Martin

National Institutes of Rental analth
5454 Wisconsin Avenue
Chevy Chase. Maryland

Dear Dr. Martin:

Enclosed is the next chapter in our continuing
interest in cyclazocina. Dick White was kind enough
to run those studies just before he left for Birmingham.

Apparently, cyclazocine compares favorably with iniprauino

in his model.

Sincerely yours.
Max

Fink. M.D.

Protester of Paydhiatry

MPH“)

�</text>
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                  <elementText elementTextId="102616">
                    <text>June 21. 1968
Dr. Joseph G. Bird

Sterling-WinthroP Research Institute
Rensseleer, New York 12144
Dear Joe,

Enclosed is a draft of a pharmacological study
of cyclazocine undertaken at the university of Tennessee.
at our request. This was presented at the Society of

Biological Psychiatry on June
in their annual proceedings.

15 and

will

be published

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

Hfzkp

enclosure

�</text>
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                    <text>June 6, 1968
Dr. E. R. Gabrieli

Director, Clinical Information Center
University of Buffalo
Buffalo, New York
Dear Dr.

Gabrieli:

letter in the

this medical school,
of the activity is in the Department of Psychiatry and we
are involved in developing a coordinated data processing system
I saw your

much

for psychiatric data.
toyyour meeting.

for

We

would

Would you

any announcements?

J.A.M.A.

In

like to send

please put us

a representative
on your mailing

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

list

�</text>
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                    <text>June 6, 1968

Ziering, R.N.
Psychiatric Instructor

Miss Hannah

The Englewood

Englewood,

New

Hospital Association
Jersey 0763l

Dear Miss Ziering:
would be pleased to have you and your students visit us
and because Thursday is the best day for part of the demonstration,
I suggest you come on June 27 and August 8.
We

The core demonstration would be a case conference held on
Thursday from 10:30 am to 12:00 noon on ward 12. If you can
arrive at 9:30 am, I will arrange for a tour prior to the
conference. From 12:00 to 1:00 we will arrange for one of the
nurses who would explain the nursing aspects of patient's care

in these units.

If you tell us the number of persons coming, I will ask to
arrange for you to have lunch and after this you will meet with
one of our physicians and a member of the rehabilitation team.
A good overview can be obtained by 3 o‘clock.
If time is short,
then we would suggest that you not attend the conference and we
can arrange for discussions from 9:30 to l2:00.
I

will arrange for our psychiatric assistants to be with
will provide a continuing commentary.

you throughout the day and they

it

As I discussed with you on the phone,
would be most helpful
I could provide the psychiatric assistants with an honorarium
for their time and I would suggest that the Englewood Hospital

if

Association sencitwo checks in the amount of $50.00 each in the
name of Manuel Rodriguez and Albert Hassan. Please send the checks

to

my

office.

Please confirm

if

the dates and times are satisfactory.
Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max

Mszp

�</text>
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                  <elementText elementTextId="102613">
                    <text>June 6, 1968
Mr. Earl Ubell

CBS News

5l West 52nd Street
York. New York

New

Earl,

Dear

If you want to know
limited in this country.

why research in marijuana is
I would suggest you read the
enclosed documents which I have Just received from the

far exceeds any requirement of the
Administration with which I have had to
comply for any drug since 1952, including hallucinogens
and heroin.
This procedure

NIMH.

Food and Drug

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszp
enc.

�</text>
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                    <text>June 25. 1968
Dr. William J. Turner
Biomedical Research Associates of the

Dreyfus Charitable Fund

177 Main

Street

Huntington. new York 11743
Dear

Bill,

I want to thank you for the reprints which
sent, relating the effects of Dilantin on
seizures. The data appear: quite sparce, and
except for the single report of Holt and Borkowoki

you

in 1951. none approach the problems of convulsive
therapy.

I have recently instituted a study of convulsive
therapy at Gracie equare Hospital and when I stimulate
a few more young residents to work there, I think I

will

look

at this

Thank you

problem.

for your c00peration.
Sincerely yours.
Max

Fink, M.D.

Profs-nor of Psychiatry

Mfzkp

�</text>
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                    <text>June 25, 1968
Mr. Stephen Root

Organization Unit

city Community Mental
Health Board
Worth Street

New York
93
New

York,

Dear Mr.

New York

Root-2

writing at the request of Miss Fini
Zolas who is applying for a position with your
organization. I have know Miss Zolas for more
I

am

than a year and she has served as the coordinator
of the Mental Health Clinic at MetrOpolitan Hospital.
Following the resignation of the clinic Director in
January 1967. I assumed responsibility for the clinic
Operation. Since I bade a prior commitment in the
develoyment in the research and training programs in
psychopharmecology. I requested the assistance of an
administrative officer to coordinate the treatment
and teaching activities of the clinic. Miss Zolas
was recommended by the executive'officer of the
Department and I have been pleased with her service

since.

During the past year, the clinic has been
reorganized so that the drOp-out rate has been

reduced significantly. the waiting time for patients
has been minimized. and the record keeping of the
unit has been completely overhaﬁled. At the time
that Miss Zolas assumed responsibility. we had no
accurate count of the patients in treatment, the
records were very incomplete. and we were faced
with one crisis after another. Miss zolaa accepted

�-"

WW

:--u|-)-7—~&lt;1r.rrvw7'wo'5“‘“'-‘-'g'":‘ﬂ

Mr. Root

~2-

June 3 25. 1968

the responsibility of reorganizing the record keeping.
providing a better system for appointments and follow—
up and in establishing inproved relations with other
units within the Department. In each of these efforts.
she has succeeded and her work has made possible the
development of a very active research and treatment
program within the Mental Health clinic.

further devalOpment of the community lental
health center. a combination of the Mental Health Clinic
and the walk-In Clinic has been entertained. In this
reorganization, I would relinquish the supervision of
the Mental Health Clinic and Miss zolas has indicated
that the new structure does not provide the same
administrative Opportunity that the present clinic does.
With

In her relations with the staff of the Clinic. the
patients and with myself, I have always found her affable.
friendly. courteous, and diplomatic. She is well liked
by the staff and instills a feeling of confidence in the
patients. In her supervision of the social workers of the

clinic, she has enhanced their growth and improved their
participation in the clinical care of patients as well as
in our conferences. In one special, that of research,
she has taken an interest and provided enthusiastic

assistance so that our present programs have been enhanced.
I regret that she has decided to seek another
position. for her association in this unit has been
most useful to me and the present improved efficiency
of the Mental Health Clinic is largely the results of
her efforts.
Sincerely yours.
)1":

"-

“ax Fink. “one

Professor of Psychiatry

wu—Iug’wzr-xw“

.v

a

Mszp

�</text>
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                  <elementText elementTextId="102610">
                    <text>June 25. 1968
Miss Helen

M. Reed

Northport.

New York

Ediciones Profesionalea. S.A.
l9 Baton'a Neck Road

Dear Mien Reed:

Enclosed are two reports of ourlatudies
of narcotic antagonists in the treatment of
Opiate dependence. as well as a summary of the
treatment model. Most of the interest has been
in the use of cyclazocine. This agent is available
in the United States for research and more than

patients have been treated. Recently. naloxone
was studied and the supply has been severely
limited so that we have been able to study its
effects in seven patients only. The results
were sufficiently exciting. however, to cause
us to ask that additional supplies be provided
by the manufacturer and these are now in production
and should be available for testing before the end
150

of the year.

the heat of

To

my

knowledge.

neither

compound

is available for clinical or research purposes outside
the United States. so that your report must restrict

itself to

a statement of the research merit only.

At

the present time. the only widely used compound in the
treatment of opiate dependence generally available is

methadone.
A

photograph is enclosed and I would be pleased

to receive copies of

E1 Medico when

thin report appears.

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

�</text>
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                    <text>Jdne 25. 1968
Dr. L. G. Heinenann
ﬂax Planck Institute

Bunsenstresee 10

34

Gottingen. Germany

Dear Dr. Heinemann:

I must apologize for this tardy reply to your
interesting letter and your reprints. Since our
report in Hadrid, we have written a number of others
describing our EEG programs and I am enclosing reprints
of these as they have recently been published.
The examples given are quite simple and do not
do justice to the power of the analysis system. As
you indicate. there is a need for greater communication

among

the

few

workers interested in this type of analysis.

those of period, power spectral
density. and amplitude analyses are available now for the
IBM 1800. This program is readily adaptable for the IBM
360 and should be easily useable in the control Data
series of instruments. If you have a programmer who is
interested in obtaining a cepy of the print-out, we will

The programs which we use,

supply one.

In this country, the best work of the kind that
to interest you is undertaken by Drs. Mirsky and
Cornetzky. both at the Division of Psychiatry, Boston
University School of Medicine, Boston. Hassechusetts.
seems

�-2-

Dr. Heineaann

June 25. 1968

While there is some decrease of travel between
Europe and the United States. I am sure that some members
of my laboratory will be in Europe this year again.
In the event we have an opportunity to visit West Germany.
it may be useful to arrange a discussion in Gottingen to
minimize the communication difficulties of letters.
work .

My

best regards

and

congratulations on your fine
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mszp

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                    <text>June 21. 1968
Dr. Richard White
c/o Dr. Phillip Bradley
The Medical School
Birmingham 15. England
.

Dear Dick,

I must. once again. congratulate you on a
fine piece of work. It is a pleasure to be associated
with this effort. Once I started to add some additional
information and references. I took the liberty of making
some small changes in the text and have had it complotely
retyped.
The original has been sent to Joe wortia.

If

Three copies are enclosed, as well as your original.
thorn are any additional corrections I an sure you can

make them

in the galley.

I look forward to hearing from you from England
and trust that your work there will be as rewarding as

you

anticipate.

I have also taken the liberty of sanding capias

to Drs. bird. Sigg. Martin. Brill and Levine each of
whom has sithsr been cited in the credits or has been
instruncntal in providing the funds for this study.
—

Hy

best regards.
Sincerely yours.
uax Pink. M.D.

Professor of Psychiatry

�</text>
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                    <text>June 25, 1968
Mr. Stephen Root

Organization unit
New York City community Mental
Health Board
93 worth Street

New

York.

New York

Dear Mr. Root:

writing at the request of His: Fini
Zolae
is applying for a position with your
organization. I have know Miss Zolae for more
than a year and she has served an the coordinator
of the Mental Health Clinic at Motrogolitan Hospital.
Following the resignation of the clinic Director in
January 1961. I assumed responsibility for the clinic
Operation. Since I hedewa prior commitment in the
development in the research and training program: in
peyohoﬁharmacolOQYo I requested the aasiatance of an
administrative officer to coordinate the treatment
and teaching activities of the clinic. Misc Zola:
wan recommended by the executive officer of the
Department and I have been pleased with her service
since.
1 am

who

past year, the clinic has been
reorganized no that the dropmout rate has been
reduced significantly. the waiting time for patients
During the

has been minimized. and the record keeping of the
unit has been completely overhauled. At the time
that miss zolaa assumed responsibility. we had no
accurate count of the patients in treatment. the
records were very incomplete. and we were faced

with one crisis after another. Misc zolas accepted

�unma-

(“nary-

Hr. Root

:IVV':-r".";

~2~

Jena

2

25. 1968

"\“‘-W

w:

,

‘w—wvl-I'W‘ln‘w-

“yr

—
.
—-v
.

w“.

the responsibility of reorganizing the record keeping.
providing a better system for appointments and followup and in establishing improved relations with other
units within the Department. In each of these efforts.
she has succeeded and her work has made possible the
development of a very active research and treatment
program within the Mental Health clinic.
With further development of the community lental
health center. a combination of the Mental Health Clinic
and the walk-In Clinic has been entertained. In this
reorganization. I would relinquish the supervision of
the Mental Health clinic and Miss zolas has indicated
that the new structure does not provide the same
administrative opportunity that the present clinic does.

In her relations with the staff or the clinic. the
patients and with myself. I have always found her affable.
friendly. courteous. and diplomatic. She is well liked
by the staff and instills a feeling of confidence in the
patients. In her supervision of the social workers of the

clinic.

she has enhanced their growth and improved their
participation in the clinical care of patients as wall as
in our conferences. In one special. that of research.
she has taken an interest and provided enthusiastic
assistance so that our present programs have been enhanced.

I regret that she has decided to seek another
position. for her association in this unit has been
soot useful to no and the present improved efficiency
of the Mental Health clinic is largely the results of
her efforts.
Sincerely yours.
Pink. ”.0.
m
Professor of Psychiatry

”mp

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                    <text>June 25. 1968
Dr. Jerome Levine

Psychopherueoology Research Branch

National Institute of Mental Health
5454 Wﬂeconein Avenue
Chevy Chase. Herylend

Deer

Jerry.

With your assistance. we have received an
Inn (4724) for the etudy of marijuana end marijuana

extracts.

Bncloeed is e copy of the FDA approval.
study progren has been accepted by the Ineeeroh
committee of the college and by the counieeioner of
Hoepitele of the city of New York. we also have e
tux stump from the Internal Revenue Service indicating
our interest in studios at marijuana.

Our

If this completes the ueuel administrative
etepe. we would be grateful for e supply of
tetrehydrocennebinol. Following the suggested
doeege of 20 mg per experiment. e supply of 600 no
would permit no to make a reasonable eetinate of
the neuroohyeiologicel profile.
Thank you very much

guidance.

for your cooperetion

end

Sincerely youre.

7—,.

~&lt;

Pink. N.D.
Profeeeor of Psychiatry

Hex

ﬂPﬂtp

�</text>
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                    <text>J. Turner
Biomedical Research Associates of the
Dreyfus Charitable Fund

Dr. William
177 Main

Street

Huntington. new Ybrk 11743
Dear

Bill.

I went to thank you for the reprints whioh
you sent. relating the effects of Dilentin on
seizures. The date appears quite sparse. and
except for the single report of Holt and BorkOWIki
in 1951. none approach the problone of convulsive
therapy.
I have recently instituted e study of convulsive
therapy at Gracie equate Hospital and when I stimulate
a few more young residents to work there. I think I

will

look

at this

Thank you

problem.

for your c00peretion.
Sincerely yours.
Mex

Fink. M.D.

Profeleor of Psychiatry

Wakp

�</text>
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                    <text>r—_—._—WV,—_,——__—T_—sc—WWV,1W.V

.
,
i-._.&gt;'r‘~wl'{*3‘e,qrPII-F'VKISV5-

».

we“... “chm—MW” . _._
.

A."

“mm"-

.,,.._....

‘

_,-

w."

“.1

.

vagawmur

.

k

“Wuhan”.

June 25. 1968
Dr.

c. Giurgea

Head

of the Pharmacological
Research Department

68. Rue Berkendael
Brueelles 6. Belgium
Dear Dr. Giurgea:

I have read your reprints with a great deal of
interest. especially your chapter on the sequential
screening of antidepressant drug: and your report at
the CINP. Both seem to make the point quite well
that the present pragmatic methods are satisfactory
in identifying compounds similar to established antidepressant agents. The real test will come in the
identification of useful psychoactive agents which
bear little reseﬂblance to the compounds of today.
In a review of our studies of cyclazocine as an
antidepressant, I am taking the liberty of referring
to your work as an example of the variety of tests
used in the evaluation of new drugs today.
thanks for your reprints and
for continued success.
My

my

best wishes

Sincerely yours.
Max

Pink. “.0.

Professor of Psychiatry

Mrskp

“me. at,

r.

“N 7‘.

z./

_

-

~

.~--

�</text>
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                    <text>-v

v»

'Wmmm‘w’t‘Vn'

-_~.r-WV|I"‘~5IV

n
r

June 25, 1968
Dr. C. Giurgea

Head

of the Pharmacological

Research Department
68. Rue Berkendael
Bruselles 6. Belgium

Dear Dr. Giurgea:

I have read your reprints with a great deal of

interest, especially your chapter

on the sequential
drugs and your report at

screening of antidepressant
the CINP. Both seem to make the point quite well
that the present prlgmatic methods are satisfactory
in identifying compounds similar to established antidepressant agents. The real test will come in the
identification of useful psychoactive agents which
bear little resemblance to the compounds of today.
In a review of our studies of cyclazocine as an
antidepressant. I am taking the liberty of referring
to your work as an example of the variety of tests
used in the evaluation of new drugs today.
My thanks for your reprints and
for continued success.

my

best wishes

Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

MF:kp

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                    <text>June 25. 1968
Mr. Thomas M. Colasuonno,

Alcohol and Drug Section
Mental Health Division

Suite 300. Tenth
10 N. W.

Director

Avenue Building

10th Avenue

Portland. Oregon 97209
Dear Mr. Colasuonno:

Last week we received a phone call from
the Public Relations Section of the Division
requesting the cirriculun vitae and photographs.
These were sent and I trust that these are

satisfactory.

the

be
it
announcement
would

Drug Problems?

possible to send

me

a copy of

of the Western Institute

on

Sincerely yours.
Pink. ”.0.
m
Professor of Psychiatry

Mszp

�</text>
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                    <text>Jdne 25. 1968
Dr. L. G. Beinensnn

Max

Planck

Institute

Bunsenstrssse 10
34 Gottingen. Germany

Deer Dr. Heinesenn:

I must apologize for this tardy reply to your
interesting letter and your reprints. Since our
report in Madrid. we have written s number of others
describing our 836 programs and I an enclosing reprints
of these as they have recently been published.
The examples given are quite simple and do not
do justice to the power of the analysis system. As
you indicate. there is e need for groeter communication
among the few workers interested in this type of analysis.
The programs which we use. those of period. power spectral

density. and amplitude analyses are available now for the
IBM 1800. This program is readily adaptable for the Inn
360 and should be easily usesble in the Control nets
series of instruments. If you have a programmer who is
interested in obtaining e copy of the print-out. we will

supply one.

In this country, the best work of the kind that
to interest you is undertaken by Drs. Mirsky end
cornetzky. both at the Division of Psychiatry. Boston
University School of Medicine. Boston. usssechusetts.
seems

�Dr. Beinsssnn

~2-

June 25, 1968

While there is some decresse otItrevel
Europe and the United States. I an sure that
of my laboratory will be in Eurupe this yes:
In the event we have an opportunity to visit

between
some

usibers

again.

West Germany.

may be useful to arrange a discussion in Gottingen
it
slninize the communication difficulties 01 letters.

work.

My

best regards and congratulations on your fine
Sincerely yours.
Mex

Fink. n.n.

Professor of Psydhiatry

HFskp

to

�</text>
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                    <text>Jun. 26.

1968

Dr. C. J. mt.’
Chairman. Departnnnc of Biological nhcnirtry
Univarsity of Athens
Laboratory Goudi
Athens 609, Graces
Dear Dr. Kirnn:
EEG studio: with
I haw. rtvicved ch. queation at aollgborntivo
marijuana with eh. Chairuan of thit Dupnrrnant and with '0'. ofRhch:
project officnrn a: tha Hational Institute of Minttl ﬂatlth.
that
are incoraﬁtsd in pursuing thin furthcr. for it auras unlikely
Evun
for
study;
tatruhydrocannabinol
at
as may rocaivn a cupply
and 1 fun: that ch.
if U! do. the appply will be twill, hawuvcr.
addirinnal
trials. A1c¢,
rcyults will b. indotcrninant, rcqnirin;
o!
an
chaurau
measurauenc
by
bu
complumanted
would
our itadies
the
described
populatian
in
such
you
as
chronic drug Iduinixtration.

in Athens.

invitation to visit with yuu
I wanid lit. to recap: your kind
1
would
hopa that this rould be
und
tho ant: til. I in in Europe
and
0!
ch.
don. bafora the
yrar.
and 11 a
staples that you thawnd II ware inconplgta
chant.
not. couploto so: could ha proviécd, I would lit: to review
tiara
ch.
(ar
tin.
ltitin
ago,
cnpocially i! a clinical dcseriprion
be
could
written
use)
of
unrijuann
dos: o! ﬁnrijunnt. durgtion
The

EEG

on arch aanplo.

Since I hsve no knowiud3u of tha populations available in
Athens. 1 canno: pieturc a reaucnublo projoc: and woula ask thc
answer to thc {allowing questions:
Uhur populations

in nn-bara of subject.

at abronic narijunna addicts 1t nvail¢b1c,
and

durntioa of radiation?

native marijuana users bu hospirnliaed and withdrawn
rnpidly in Athcns to that thc changes on withdrawal could be nonsuradf
Could

flﬂmp

.,
r...

A

-

y
«:w-

':'—‘v"~mvwmm-g-rsv

�:9:-

Dr. Hires

~2-

June 26, 1968

If an experiment

were planned for next winter, could acute
be
undertaken
a population of non—chronic users of marijuana
in
trials
Could
at your institution?
you supply tetrahydrocannabinol in sufficient
quantity to undertake a reasonable number (30-40) trials?
What

project outline

have you already discussed with NINE.

especially with regard to the
marijuana use?

EEG

In what specific ways could

aspects of chronic or acute

we

be of

assistance?

Finally, through what grantee agency have you received )ublic
Health Service Grants recently?

I look forward to hearing from you. I am taking the liberty
of sending a COpy of this letter to Dr. Henry Brill, whose assistance
will be invaluable if we are to undertake such a program.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

cc:

A. M. Freedman
H.

Brill

�</text>
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                    <text>&lt;
v

.,.

v

pruwuamr-n-r

v

,u
a

.m,,..-,-,

any"...

“g.

15,-3.1“...

{-

Juno 26. 1968

numwra

""‘K'K'ma

Dr. William Tabor

A. H. Rabin!
v

.1

(ww-

va-myv-z-mpm-p

an.

.

&amp;

Company

1407 Cunning: Drive
Richmond 20. Virginia

near Bill.

us-wr

«w-

&lt;v

c-

awtm’ﬂ‘c

W7~V~&gt;~o

0
4m;

.I'I'V’ﬁ'ﬂwwynw

In a recent letter you inquired as to our
procedure in adding some tasteful subatance to the
placebo of butaperazina elixir. Adopting a simple
procedure from our community, we have added to the
vehicle a small amount of Angoatura Bitters. This
has added a taste to the medication and, while
distinguishable from butaperaaine on direct trials.
has been of some use in our work.
have summarized each of the cases in the
present population and are now transcribing some of
We

the information to the Robina worksheets. We are
also preparing a written summary of our observations.
As soon as these are available. they will he coat to
you.

My

halt regards.
sincerely yours.
Max

Pink. Md).

Professor of Plyohiatry

Hszp

�</text>
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                  <elementText elementTextId="105614">
                    <text>June 26, 1968
Dr. Melvin Therner
Schering Corporation
Bloomfield, Rev Jersey
Deer Mal,

is a preprint of the initial report on the high
dose fluphenazine study as presented at the CINE meeting in
Enclosed

Tarragona in April.

I am also enclosing a xerox copy of the letter from the
British Medical Journal. I believe that these experiences

do support the merit of a very high dose fluphenazine study.

As I indicated at the ECDEU meeting, Dr. Barry of White
Laboratories called me last week to state that they have made
a concentrated syrup (100 mg/cc) and this should be available
for clinical trial in the early fall.

that amitriptyline may have antiparkinaon
qualities intrigues me and I will look into this further.
Your comment

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
rd

"—7",

wvrvr-n

u-a

.

erI-wmv

.sz-wnku,

MP:kp

�</text>
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              <elementText elementTextId="97277">
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                  <elementText elementTextId="102602">
                    <text>June 26, 1968
Dr.

J.

S.

Gottlieb, Director

Lafayette Clinic
951 E. Lafayette

Dttroit, Michigan

48207

Dear Jacques,

It

of you to send me the latest review of the
of
schizOphrenia. The findings do fit together,
present theory
and I am impressed that the data is also consistent with other
evidence not included in the review.
was kind

Many

studies suggest that the

EEG

patterns of schizOphrenics

are different from other populations — in greater degrees of
desynchronization and beta activity, and in an enhanced response

to intravenous barbiturates. That these observations are rarely
confirmed may relate to the variability of the presumed permeability
changes you postulate (as well as the invariable differences in
techniques).

theory is also consistent with the differences in EEG
responses to psychoactive drugs among schizophrenic, depressive
and normal populations, with the schizophrenic populations showing
a more rapid and/or excessive response.
The

»r
9‘:
w‘,

,
2:.

uwuwfq

Again, my thanks for a fine report; and my added admiration
for the 12 year review which accompanied it. As one who tried to
establish a stats-based research center and failed, your success
in asking the Lafayette Clinic the outstanding center that it is

bespesks an unusual

Hy

congratulations.

political

acumen and a hulldogged determination.

1,7,.“-

Sincerely yours.

,v

5"}..r;

was

as;

tun—7r.»

,

Fink, M.D.
Professor of Psychiatry

Max

.._

,.

"3“?

.a‘x

'7':va

WY”.

Emma;

MF:kp

�Dear Jacques,

It

was kind

of you to send

me

the 1atest review of

the present theory of schizophrenia. The findings do
I am

impressed that the data

fit

together,

a4zoL

the-

iéjgonsistent with other evidence not

inciuded in the review.
Many

studies suggest that the

EEG

patterns of schi20phrenizs

are different from other popuiations-- in greater degrees of desynchron-

ization

and beta

activity,

and in an enhanced response

to intravenous

barbiturates. That these observations are rareiy confirmed

reiate

may

variabiiity of the presumed permeabiiity changes you postuiate[4/v
44-ﬁ1,u40ﬂw,.,/e.
agjﬁ
x7yuyt,,, fa, franu.differences
.
The
aiso
to the

theory is

consistent with the

in

EEG

responses to psychoactive drugs among schizophrenic, depressive
and normal
a more

popuiations, with the schizophrenic popuiations showing

rapid and/or excessive response.
Again,

for the

thanks for a fine report; and

it.

year review which accompanied

12

estabiish

my

a

state-based research center

and

As

my

added admiration

one who

tried to

faiied, your success

in making the Lafayette Ciinic the outstanding center that

s

4,,

it

is

bespeakd an unusuai poiiticai acumen and bu11dogged determination.
My

congratuiations.

m,
72%

�</text>
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                    <text>Jun: 27, 1968
Dr. Alfred M. Freedman
Departnont of Psychiatry
Now York Medical College
5 East 102nd Street ‘
new York. Now York 10029
Door Dr. Froednan:

writing to rocommcnd the nomination of Dr. Charles F.
Stroebel for membership in the APPA.

I

am

I have known of his work sine. 1962 when he came toHe tho
had
Inctituto of Living from the University of Minnesota.
Hillside
boon rccommonded by Gordon Heistad for a position at
Hospital but I could not arrange this, although I wanted to,
since I

knew

I

was leaving.

Dr. Stroebol has done many fine studies in neurOphyaiology,

specifically in the area of diurnal rhythms. He has fine computer
experience and is an excellent statistician.
I would be pleased to have him participate in the meetings

-

A

.

of tho

4-

‘

APPA.

Sinccrely yours,

~1-rr-Iyuorxiu».v.-

Fink, ﬁ.D.
Professor of Psychiatry

Max

Hrzkp

cc:

-

.

.

.
.

.u-E"

31$.

r”:

lnxwgmvk

Dr. Gluock

�</text>
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                    <text>"—

,w-

.mu—u

.v
.r'wr

"var-s»

‘I-u-

June 27, 1968

J. Fitzgerald, Jr.
District Director of Internal

Mr. Edward

120 Church Street
New York, New York
Dear Mr.

Revenue

Fitzgerald:

Please send us the necessary forms to register in Class 6 Herihuene, so that we can fully comply with the request of the
Department of Health of the State of New York.
Sincerely yours,

:“W

M
w.

~5th

.

Hex Fink, Md).

Professor of Psychiatry

Hrzkp

�</text>
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                  <elementText elementTextId="102600">
                    <text>June 27, 1968

Jr., Director
Narcotic Addiction Control Commission

Mr. Louis E. Moon,

Executive Park South
Stuyvesant Plaza
Albany, New York 12203
Dear Mr. Moon:
The

following is in answer to your inquiry of June 21, 1968.

TR-34: This form is completed when a patient is admitted to
Metropolitan Hospital for detoxification and additional treatment.
TR—33: Completed when patient is either discharged against
advice, or discontinues the aftercare program by not returning
within a month of the date of visit or completes a period of inpatient and out-patient care and we have decided that no further
treatment is necessary.

Treatment completed implies that no other services in

institution are

deemed

useful for the patient.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kp

cc:

Mr. Schwartz

this

�</text>
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                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Correspondence -- Correspondence</text>
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                <text>The Max Fink Collection</text>
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            <description>An account of the resource</description>
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                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <description>A language of the resource</description>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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        <name>Correspondence</name>
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