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                    <text>June
_

l1,

1968

Mr. Hayes A. Dorr

Coordinator, Special Projects
Institute for Scientific Information

Street
Philadelphia, Pennsylvania
325 Chestnut

19106

Dear Mr. Barr:

for your letters regarding the ASCA III Program.
I believe a trial subscription might be useful and I am
enclosing two pages of profile entries which follow your
model. If I am correct. the six items listed as
suggested
lA and eight items as 1A3 should result in citations if one
word or stem from any 2 of the 3 groups is cited. Thus EEG,
Period Anal; or Computer/Drug; or Electroenceph/Psychot will
Thank you

result in

citation.
Similarly, any articles citing Adey's article in ﬁngerimental
Neurolggy will be listed.
a

If these

correct. I
suggested charge for this service for one year.
two understandings are

would 1ike a

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>June 10. l968
Dr. John C. Kramer

Chief of Medical Research
Department of Corrections

California Rehabilitation Center

P. O. Box

l4l

Corona. California
Dear John,

Rockefeller Meeting on June Zl~22 has the aura of
religious conversion performance. I will probably ask a
member of my staff to attend on Saturday morning to see
if
the results have dropped below 97% success.
The

a

Saturdays in June are beautiful in

will probably find
How

me on

about coming out?
My

best to

New

York and you

the tennis courts in Great Neck.

Supper?

Deena.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 6. 1968
Mr. Donald Cheetham

Smith Kline and French Laboratories
l500 Spring Garden Street

Philadelphia, Pennsylvania
Dear Don.

As I indicated in my previous letter, one of our
associates is interested in undertaking a study of parnate
.

and chlorpromazine in the treatment of anergic schizophrenic
patients. Enclosed is a c0py of the protocol.
I would be grateful if Smith Kline and French could
available supplies of parnate and parnate placebo
for this study. If so, I would appreciate an initial
supply of lOOO mg tablets and 500 identical placebo tablets.

make

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

�</text>
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                    <text>June 6, l968
Mr. Earl Ubell
CBS News

51
New

Nest 52nd Street
York, New York

Earl,

Dear

If you want to know
limited in this country.
enclosed documents which

why research in marijuana is
I would suggest you read the
I have Just received from the

far exceeds any requirement of the
Administration with which I have had to
comply for any drug since l952. including hallucinogens
and heroin.
This procedure

NIMH.

Food and Drug

My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp
enc .

�</text>
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                    <text>June 6, l968
Dr. Burtrum C. Schiele

Professor of Psychiatry

Department of Psychiatry and Neurology
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dear Burt,
I have just spoken to Joe Bird and since no meeting of
the investigators of cyclazocine is being planned for June,
I am suggesting that perhaps we can get togehter during the
ECDEU meetings on June 24-25.
In the meantime I am enclosing
the prepublication copies of the two reports from this and
Dr. Itil's laboratory which will be completed in the next few
weeks and sent to a psychiatric journal.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>June 6. 1968

Ziering, R.N.
Psychiatric Instructor

Miss Hannah

The Englewood Hospital Association
Englewood. New Jersey 0763l
Dear Miss Ziering:
would be pleased to have you and your students visit us
and because Thursday is the best day for part of the demonstration,
I suggest you come on June 27 and August 8.
We

The core demonstration would be a case conference held on
Thursday from 10:30 am to 12:00 noon on ward l2. If you can
arrive at 9:30 am. I will arrange for a tour prior to the
conference. From 12:00 to l:00 we will arrange for one of the
nurses who would eXplain the nursing aspects of patient's care

in these units.

tell us the number of persons coming. I will aSk to
for
to have lunch and after this you will meet with
you
arrange
one of our physicians and a member of the rehabilitation team.
A good overview can be obtained by 3 o'clock.
If time is short,
If

you

then we would suggest that you not attend the conference and
can arrange for discussions from 9:30 to l2:00.

we

I will arrange for our psychiatric assistants to be with
you throughout the day and they will provide a continuing conmentary.

it

As I discussed with you on the phone,
would be most helpful
I could provide the psychiatric assistants with an honorarium
for their time and I would suggest that the Englewood Hospital
Association sen&lt;1two checks in the amount of $50.00 each in the
name of Manuel Rodriguez and Albert Hassan. Please send the checks

if

to

my

office.

Please confirm

if

the dates and times are satisfactory.
Sincerely yours.
Fink. M.0.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="102635">
                    <text>June 6, l968
Dr. Jack H. Mendelson

National Institutes of Mental Health
Alcoholic Research Center
5454 Wisconsin
Chevy Chase. Maryland
Dear Jack,
As I mentioned, I am writing a review of the EEG changes
with psychoactive drugs for the Annuaz Review'og Phanmaeology.
like to include a summary for the recent studies with
IINggl?
o

a c

that

.

I would be grateful for any
I can check against my own.

from your files
Thank you very much.

citations

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>June 6, l968
Dr. Roger Meyer

Acting Director

Center for
NIMH

Drug Abuse

5454 Wisconsin
Chely Chase, Maryland
Dear Roger,

is a from I have just received from Dr. Scigliano.
It seems to that a submission of this kind is more extensive
than any submission I have had to make for any drug since I
became interested in this problem in 1952. The submission is
Enclosed

me

I have had to make for such hallucinogens
as Ditran and. more recently. heroin.

also greater than

patiently cooperated with various
May l967 and can now fully undersince
governmental agencies
amount
why
stand
of marijuana research has been so limited.
the
In the event that you can assist me in obtaining supplies of
THC or marijuana without once again going through these formalities.
As

you know. I have

grateful.
feel that it is mandatory that

I would be most
Do

you

unhealthy procedure?

we

follow this

Sincerely yours,
Fink, “.0.
Professor of Psychiatry

Max

MF:kp

cc:

Dr.

J. Levine

�</text>
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                    <text>June 6, 1968
Dr. E. R. Gabrieli

Director, Clinical Information Center
University of Buffalo
Buffalo,

New York

Dear Dr.

Gabrieli:

letter in the

J.A.H.A. In this medical school,
of the activity is in the ﬁepartment of Psychiatry and we
are involved in developing a coordinated data processing system
for psychiatric data. He would like to send a representative
toyyour meeting. Would you please put us on your mailing list
for any announcements?

much

I saw your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>June 6, 1968
Dr. Joseph 6. Bird
Sterling Winthrop Research

Rensselaer,

New

York

l2l44

Institute

Dear Joe.

Separately

I am sending you complete data folders and
patients who received cyclazocine in the
cyclazocine-depression study at the New York Medical College

summaries of 19

and Nos. 072-098 of

patients receiving cyclazocine in the
treatment of narcotic addiction. I trust this data is helpful.
Thank you

studies.

for your assistance in carrying out these
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>August 30, 1968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

that we have not sent you samples of the
data
output. I was waiting for xerox copies of the
laboratory
but
these will not be available for a few more days.
full set,
In the meantime, enclosed are sample sets from one of our analyses.
Don

reminded me

The laboratory standards are our standards and your reports
will, of course. have a similar set with your standards listed.
Where
states New York Medical College, we will list MIP.

it

Each individual sheet is a single report from a single optical
scan sheet. The age, sex, date. drug and dosage were keypunched
separately from lists supplied by my staff. In the new forms
this data will come directly from the form. The third type of
output is a listing of all the tests for each patient and this
is derived directly from the individual sheets (you will note
that these do not have drug or dosage listed for each date and
this will be corrected in the new forms).

are able to handle the MIP-PLD forms and provide you
with these outputs. To do so would require the forms and a
clear statement on the head of each form of the mate. drug,
dosage, age and sex of the subjects.
We

can provide outputs for your present forms
be able for the new forms within two months.
We

now

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

and should

�</text>
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                    <text>August 29 , 1968
Dr. Hanns Hippius

Direktor der Psychiatrischen Klinik
Preie Universitat Berlin

II

Nussbamralle 36

1 Berlin 19 Germany

Dear Dr. Hippius:

I am pleased to send you copies of our report on cyclazocine
in the treatment of narcotic addiction as well as preprints of
the use of this drug in the treatment of depression. As I
mentioned to you in Spain, we came upon the use of cyclazocine
as an antidepressant from its m profile. The data is described
in these two reports. Of course, further study is necessary and
I hope that others will make the necessary independent investigations.
My

best regards .
Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

�</text>
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                    <text>August 22, 1968
Dr. Sidney Merlin

Central Islip State Hospital
Central Islip, New York

Dear Sid,

I

am

writing to recommend a promotion of
to Fellow of the ACNP.

from Member
Dr.

Dr. Turan

M.

Itil

has been a leading worker in the field of psychoItiland
electroencephalography since 1955. Since joining

pharmacology
the Missouri

Institute of Psychiatry in

unusually
active in establishing new drug evaluation programs, experimental
studies in schizophrenia, and continued his interest in EEG. He
has been most productive and has published more than 30 articles
from the Institute alone.
1963 he has been

has been an active member of the ACNP and has attended
every meeting. He has been Co-Chairman of the Section on
Neurophysiology for the past two years and was elected to this
He

position

by the members of

that panel.

his university he has been promoted from associate
professor to full professor and has been named Assistant Chairman
At

of the Department.

In view of his particular interest and enthusiasm for psycho—
pharmacology, his active participation in the College, and in
recognition of his many contributions, I am pleased to recommend
him for Fellowship.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

�</text>
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                    <text>August 22, 1968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

I very much enjoyed my visit and have completed some
of the things on my agenda. Grass Instrument will ship two
amplifiers and they should arrive early next week.
Dr. Barry is coming to visit on Friday, August 231 He
does not need a protocol but suggests that we take care of the
full filing with the FDA ourselves. As soon as I have an IND
number, he will ship the supplies of fluphenazine.

I have already dictated a letter to Sidney Merlin
for Fellowship in the ACNP.

recommending you

Enclosed are the bills for some of the computer time at
the College. The lab scale ~ psychopharmacology bills represent
one—half the costs to date. It would be most helpful if payment
for these charges can be made to "Division of Biomedical
Information Processing ~ New York Medical College“ and sent
to Dr. Donald Shapiro at 5 East 102nd Street, New York. New York 10029.

I
My

am

also enclosing a statement for

my

visit that is appropriate.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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Librarian
New

2

York Academy of Medicine

East 103rd Street

New

York,

Mew

York

Dear Madam:
I wouId be gratefu1 if you wouId permit Dr. Rhea Dornbush
to work in the Iibrary during the hours open to Fe110ws as she

is working

If

on a

project for

me.

it necessary to take out books and journaIS.
her doing so.

she finds

I wouid approve

Sincerer yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 20, l968

Felix Morrow
l0 Old Colony Lane

Mr.

Great Neck,
Dear

New

York

Felix,

pleased to enclose a copy of an outline of a
called either "Lectures in Psychopharmacology“,
"Psychopharmecology. A Neurophysiologic View" or just
"Psychopharmacology." In addition I am enclosing two reports
which form the basis of two of the chapters. A third report
is enclosed to give you a view of the general field.
I am

volume to be

I would be grateful
proper way to present in
My

for your suggestions regarding the
writing such a volume.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Mex

Mszp

�</text>
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                    <text>August 19, l968
Dr. Allen Raskin
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland

,

Dear Allen,

Enclosed are the initial reports on cyclazocine as an
antidepressant as submitted for publication. I trust these
meet your expectations. Dr. Bird has called to say that he

plans to hold

a meeting

in late September.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF2kp

�</text>
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                    <text>'
r

‘
'

'

August 19, 1968
Dr. Seymour Kety

Massachusetts General Hospital
Boston, Massachusetts 02ll4
Dear Seymour,

of your interest in our experiences with

Al

told

My

best regards.

me

cyclazocine as an antidepressant as well as an anti-narcotic.
Enclosed are two reports as submitted for publication. They
lack the necessary controls and are only suggestive as they
stand. Derived from the EEG-behavioral model, these experiences
support the need for further trials of the EEG model, and for
cyclazocine, the need for independent controlled clinical trials.

KHFXIWHF’”!

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

�</text>
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                    <text>August 19, 1968
Dr. Heinz E. Lehmann

Ciinicai Director

Dougias Hospitai
6875 Lasaiie Blvd.
Verdun. Quebec,
Canada
Dear Heinz,

It

has taken many years to deveiop a asabie EEG predictor
for novei psychoactive drugs. The enciosed reports of
cyciazocine as an antidepressant have been submitted for
pubiication. Knowing of your intereSt and enthusiasm for new
drug evaiuations, perhaps these experiences may suggest simiiar
experiments with other novei compounds.

model

My

best regards.
Sincerely yours,
Max

Fink, M.B.

Professor of Psychiatry

�</text>
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                    <text>August

l9,

1968

Dr. Jerome Levine

Psychopharmacology Research Branch

national Institute of dental Health
5454 Wisconsin

Chevy Chase, Maryland

Dear
on

Jerry,

draft copies of recently completed reports
the antidepressant qualities of cyclazocine. were it not
Enclosed are

for the neurophysioloqic data I would hesitate to report such
uncontrolled studies. Perhaps the studies now in progress may
confirm the View and lend some additional Inpport for the EEGbehavioral association model.
for the THC. He will begin the
I am also pleased to tell you
and the clinical studies are
in
naloxone
supply
is again
that
many thanks
summer recess.

Incidentally,

study after the

again in progress.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August

l9, l968

Dr. William Tabor

A. H. Robins Company
l407 Cummings Drive
Richmond 20, Virginia

Dear

Bill.

pleased to enclose our second interim report in our
analysis of the fenfluramine. amobarbital. dextroamphetamine
EEG study.
After an hiatus of many months. we have been able
to get back to this analysis and find that the results, regardless
of which technique of analysis we use, are the same. Fenfluramine
is most distinguishable from amphetamine and least from 50 mg
I am

amobarbital.

are anxious to report this material in the scientific
press and will do so shortly. In the interim, however. you
may feel free to make conies and distribute these within
A. H. Robins or for any governmental submissions which you
may feel necessary.
We

In addition to this report I am enclosing individual case
records of the volunteer subjects in the fenfluramine EEG study.
While in St. Louis on Friday, I discussed the individual case
records of the fenfluramine reaction time subjects with Dr. Itil.
I gave him the forms and he assured me that a member of his staff
would complete them on Monday or Tuesday at the latest and send
them directly to you. Since he felt that he could accomplish the
mission without any assistance from me, I trust this is satisfactory.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc .

�</text>
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                    <text>August

l9, l968

Dr. Nathan S. Kline

Director of Research
Rockland State Hoseital

Orangeburg.

New

York

Dear Hate.

It

has taken many years to develop a usable

EEG

predictor

novel psychoactive drugs. The enclosed reports of
cyclazocine as an antidepressant have been submitted for
publication. Knowing of“your interest and enthusiasm for new

for

model

drug evaluations. perhaps these experiences may suggest similar
experiments with other novel compounds.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 19, 1968
Dr.

J. F.

Remarque, Vice President

Elsevier Publishing

P. O. Box 211

Company

Amsterdam, The Netherlands
Dear Dr. Remerque:

For more than a decade I have studied convulsive therapy, psycho—
pharnacology and electroencephalography. During the past year, I prepared
a series of seminars in peychopharmecology viewing this discipline from a
neurophysiological and experimental point of view. The seminars were well
received and I now have the staff response in addition to the notes.

is a suggested outline of a volume which I would like to
with
write
either of the following suggested titles:
Enclosed

An

Psychopharmacology
Experimental (or Neurophysiological) View

I will project the volume for psychiatrists, experimental psychologists.
clinical neurologists. The focus will be on the variety of
psychoactive drugs of the last two decades. It will include the latest
experimental data from computer, EEG, psychophyeiology and sleep laboratories.

and perhaps

Each chapter will be between 15 and 20 double spaced type~written
pages. The number of citations will be extensive, probably averaging
forty for each chapter, but should not exceed 400 for the volume.

I believe such a

If

contact

such e venture

me.

volume can be prepared

interests you, I

in 9-12 months.

would be pleased

ti

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkp

you would

�</text>
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                    <text>August 19 , 1968
Mr.

Earl Ubell

“CBS—TV

518 West 57th

New

York,

Dear

Street

York

Earl,
For some time I have been interested in writing a book on the

E

‘

New

relation of drugs, EEG and behavior and would like to undertake this
mission this“ fall. I recognize that while the content of my writing
is scientifically accurate, its style is poor and needsthe assistance
of someone capable of handling scientific writing with clarity as the
principal objective. Can you recommend, or would you inquire of your
brother or friends for someone who might assist me in preparing a
better presentation this winter?

;
i

;

Laboratories made naloxone available and the
Public Health Service, tetrahydrocannabinol, both on the same
day last week, so that we are able to undertake these studies after

U. 8.

Incidentally

ENDO

Labor Day 0

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August 19, 1968

Dr. Stratton
Grune and

Stretton

381 Park Avenue South

New

York,

Dear Dr.

New

York

Stratton:

For more than a decade I have studied convulsive therapy, psychopharmacology and electroencephalography. During the past year, I prepared
a series of seminars in psychopharmscology viewing this discipline from a
neurophysiological and experimental point of view. The seminars were well
received and I now have the staff response in addition to the notes.

is a suggested outline of a volume which I
write with either of the following suggested titles:
Enclosed

An

would

like to

Psychopharmacology
Experimental (or Neurophysiological) View

I will project the volume for psychiatrists, experimental psychologists,
clinical neurologists. The focus will be on the variety of
psychoactive drugs of the last two decades. It will include the latest
experimental data from computer, EEG, psychophysiology and sleep laboratories.
and perhaps

Each chapter will be between 15 and 20 double spaced type~written
pages. The number of citations will be extensive, probably averaging
forty for each chapter, but should not exceed 400 for the volume. You

may know

that I have already edited the Bibliogkaphy

Paychophwrmozogy (Etwowenceph.

can.

Eleevier) and recently, Anticholinaﬂgic

Animu£4 and Man (Pnogkebb

P. Bradley).

I believe such a
you.

If

such a venture

in

Nwoyohyaiot. , Supplement 23,

Unugé and Bkain Functiona

Benin Reéeatch, 28,

volume can be prepared

interests you, I

06 EEG and Human

Elsevier,

in 9-12 months.

would be pleased

to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

in

1968, with

meet with

�</text>
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                    <text>2.:

.—

a—vv

1117",“.

'r

».--

v

.

my

-

(«up

-

s

,

..~v--~-- I‘w

..

'rvrn-

,

--—

--.-w-

..

A»

var,

-

~-.-

-...-.-..«

7

m

August 19, 1968
Dr. Seymour Kety

Massachusetts General Hospital
Boston, Massachusetts 02114
Dear Seymour,

told me of your interest in our eXperiences with
cyclazocine as an antidepressant as well as an anti-narcotic.
Enclosed are two reports as submitted for publication. They
lack the necessary controls and are only suggestive as they
stand. Derived from the EEG-behavioral model, these experiences
support the need for further trials of the EEG model, and for
cyclazocine, the need for independent controlled clinical trials.
Al

My

best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

�</text>
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                    <text>a, new. a—
-

August 16, l968
Dr. Jonathan 0. Cole

Superintendent
Boston State Hospital

Boston, Massachusetts 02l24
Dear Jon,

Enclosed are the initial reports on cyclazocine as
an antidepressant as submitted for publication to Dr. Braceland.
This suggestive confirmation of the EEG predictor model for
psychoactive drugs has stimulated ongoing studies of doxepinc.
Al

Perhaps you

DiMascio.
My

may

wish to share these reports with

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>August 9, 1968
Ma. 1. w. Kuntz, la.
The Blue Line Chemical Company

302 South Enoadway

St.

LouiA, Mibbouni 63102

Dean Mn. Kuhtz:

Thank gnu veny much 604 youn pnompt and most uAe5u£ nepﬂy.

I do not know how we miéaed théb item not how the phanmaciat
did, but we axe abze to obtain the amputea 5aom E££ titty and
thia udlz indeed make can paoject ﬁeaaibte.
Many

thanké 50a youa heﬁp.

Sinceaeiy
Max

Fink,

younA,

M.U.

Pnoéebaqa 05 Péychéatag
MF:kp

�</text>
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                    <text>v... &lt;.—. mn-

».«—

-

—,

.

..

_

4...,"

.--————~~. ~r-a—~ «ivy—v

”WM—v—wr."m~.~-yw vgrww-v—

.

V—w

"‘3".an

a...“ urc'

»

murmur-‘7' m

“Wt‘V'rr—r‘wvz' "up

August 8, 1968
Dr. Norman Weiss

Chairman, Program Committee

Queens County Psychiatric Society
109-10 Queens B1vd.
Forest H1113, New York 11375
Dear Dr. Weiss:

to speak to the Queens County
The two dates you have se1ected,

I wou1d be p1eased

Psychiatric Society.

December 10 and 17 occur
am

away

for meetings.

I can make a

at

1ecture in

approximate1y the same time.

a time

of the year

November

when I

or January at

Perhaps the best wou1d be for you to ca11
at (212) 369-7900 Ext. 245.

any afternoon

my

office

Sincere1y yours,

Fink, M.D.
Professor of Psychiatry
Max

Mszp

._. .w--

'1"

"rev-w”

I'u—‘llet'Y—rrWVV

w.”-

-..-v

�</text>
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                    <text>1,,

August

8,

1968

Dr. Norman Neiss
Chairman, Program Committee

Queens County Psychiatric Society
109-10 Queens Bivd.

Forest Hiiis,

New

York 11375

Dear Dr. Weiss:

pieased to speak to the Queens County
The two dates you have selected,
December 10 and i7 occur at a time of the year when I
am away for meetings.
I wouid be

Psychiatric Society.
I can make a

approximateiy the

lecture in

same

time.

November

or January at

Perhaps the best would be for you to call
afternoon
at (212) 369-7900 Ext. 245.
any

my

office

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszp

"~-

�</text>
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                    <text>T

“

w-

w.n~w.r—-~ntr-v.-r-u .. ...
,

.

w.

"my... ‘_

1r»wr:t-

_

.

~4v-.~:.~,—m--m;n,--m»v..‘u

w,—-

W»

‘0'." V"U'-v,—w-r~—

w-

.v

v...—».,ku.ru-u.---~

-.,

vn

~-

»

~

-»-~ .

. ..., '-W-

F5.

August 8. 1968
Dr. G. B. Biane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons, Ltd.

Huii, Engiand

Dear Dr. Biane:
For the past two years we have studied the conditioning
theory of narcotic addiction as expressed by Wikier. We started
with cyciazocine and carried out some studies with naioxone.

Cyciazocine has the disadvantages of a narrow therapeutic
index and naioxone appears to have a very short duration of
action. Despite these iimitations, both treatments appear to
foiiow the deconditioning modei and have shown sufficient promise
to excite us to continue. We are interested, however, in any

other narcotic antagonists

which can be of longer duration of

action and with fewer side effects.
I am

enciosing copies of our reports which wiii bring you

up—to-date in our present program.
.

In the event that SOSO-M, or other active antagonists
goes to human triai, we wouid be anxious to test it.

Sincerely yours,

~_v,ww..wnv,_

Fink, M.D.
Professor of Psychiatry

Max

mmﬂwmuvm.mwﬁlwvmww

.m

.
.~

Mszp

v—

m

W»

W

~

.

�</text>
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                    <text>August 7. 1968
Dr.

J.

F. Remarque. Vice President

Elsevier Publishing

Company

P. O. Box 2ll
Amsterdam. The Netherlands
Dear Dr. Remarque:

Please send me ten additional cooies of Antichoﬁinexgic
ﬂange, Volume 28. Pnogaeob in Baain Reaeanch and bill me
accordingly.

Thank you very much

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>August 7. 1968
Dr. Turan H.

Itii

Missouri Institute of Psychiatry
5400 Arsenai Street
St. Louis, Missouri 63139
Dear Turan,

Enciosed is a draft of the paper by Drs. Schwartz and Feidstein.
the tapes have been analyzed but these were not completed
before Dr. Schwartz went on vacation. I expect him to return
in September, since he is in Engiand. At that time I hope he
will go over the material and rewrite this report inciuding
an outline of the next important steps.
A11

My

best regards.
Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>August 6. 1968
Dr. Lee Gordon
Hoffmann-La Roche. Inc.
Nutiey, New Jersey 07110
Dear Dr. Gordon:
Mr. Heisman was kind enough to approach us regarding a
high dose Librium study. As you may recognize such a study

does not stimu1ate much interest in the treating physicians
since they have a ready accepted high doses as a standard.
As this has been the first study that Hoffmann-La Roche has
recommended, I regret that we are unab1e to carry
out.

it

Some years ago I undertook phase 3 and phase 4 clinica1
eva1uation studies at Hi11side Hospita1. Nhi1e in Missouri
I found phase 2 and 1ate phase 1 studies of greater interest
and deve10ped, in conjunction with my associates. Drs. Iti1
and Shapiro, a method of EEG anaiysis which we fee1 contributes
to our understanding of the mode of action and target popuiations
for new psychoactive drugs. I am taking the 1iberty of enc1osing
a copy of a review of EEG and drug effects which I prepared for
the ACNP in 1967.

are particuiar1y interested in phase 2 and 1ate phase 1
studies, especia11y those which permit us to utiiize our EEG
mode1. The faci1ities for new drug eva1uation in this Department
are extensive and inc1ude two EEG 1aboratories and a computer
faciiity, a 25 bed in-patient unit for narcotic addicts and
psychotic patients, a 1arge menta1 hea1th c1inic servicing a
wide variety of popu1ations, and 1ate1y a speciai out-patient
unit for chiidren and ldo1escents. It might be useful for you
or some of your associates to visit our faci1ities in order to
obtain an appreciation of the opportunities which they represent.
We

Sincere1y yours,

Max

Fink,

M.D.

Professor of Psychiatry

Mszp
cc:

Mr. H. Heisman

�</text>
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                    <text>August a, 1968

M. Human S. 01me
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V

.

r

"WWVWWV ~1nm-vvww-wt

r

“"‘».——v|"':-wv-

mwvwwm,

mmmv— .

August 6. l968
Hrs. Carol Kehn

Medical World News
299 Park Avenue
New York, New York
Dear Mrs. Kahn:

Enclosed is the reprint you requested. I am also sending
preprint of the very high dose fluphenazine study. If
this interests you it may also interest your readers. not only
as a statement of treatment efficacy, but also as an example
of the impact of present governmental regulations on American drug
We found it difficult to undertake these trials here
research.
and elected to carry out the study in Istanbul.

you a

now have more extensive follow-up data and
more rewarding than the initial evaluations.
We

it

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

is

even

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                    <text>August 6, 1968

W

Dr. Greenwell
Howell Laboratories

Baudette,

MRAAQ‘CDO

Dear Dr. Greenwall:

K

As an academic institution, we are interested in providing
an opportunity for our students to treat manic patients with
lithium carbonate and to observe its activity.

I contacted Dr. Charles Shagsas of Temple University who
me that your laboratories can make lithium carbonate
available for trials and may assist us in filing'an IND with
informed

the

FDA.

May I request a price list for lithium carbonate, and
permission to quote your manufacturing and other data in our
IND?

Thank you

for your cooperation.
Sincerely yours,
Fink, 24.0.
Professor of Psychiatry

Max

�</text>
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                    <text>August 6. l968
Dr. Turen M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Turan,

Separately

I am sending you

five capies of the report

”Cyclezocine Classified as an Antidepressant by EEG
Criteria and its Clinical Trial". Following our discussions,
I am sending it to Dr. Bracelend for his consideration for the

Amentcan Jounnat 06 Psychiatny.

I am

believe that this report should have

not optimistic, but
exposure.

a wide

I am also enclosing a few copies of the companion report
reflecting the work in New York. I have asked Dr. Braceland

to consider both reports together.

Finally, I am enclosing a new review on EEG and drugs
which I have prepared for the Annuaz Review'oﬁ Phanmacology.
I trust
does Justice to your work.

it

I look forward

to seeing you on August 16.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>August 6, l968
Mrs . Carol Kahn

Medical World News
299 Park Avenue
New York, New York
Dear Mrs. Kahn:

is the reprint you requested. I am also sending
preprint of the very high dose fluphenazine study. If
this interests you it may also interest your readers, not only
as a statement of treatment efficacy, but also as an example
of the impact of present governmental regulations on American drug
We found it difficult to undertake these trials here
research.
and elected to carry out the study in Istanbul.
Enclosed

you a

He now have more extensive follow-up data and
more rewarding than the initial evaluations.

it is

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

even

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                    <text>August 6, 1968
Dr. Greenwell
Rowell Laboratories

Baudette,‘ﬁ!!tuu!!a
M '\ ﬁxing/5 ¢%c\

Dear Dr. Greenvell:

institution, we are interested in providing
for our students to treat manic patients with

As an academic

an opportunity

lithium carbonate and to observe

I contacted Dr. Charlea

its activity.

Shagaaa of Temple University who

that your laboratories can make lithium carbonate
available for trials and may assist us in filing an IND with
FDA.
informed

me

the

May I request a price list for lithium carbonate, and
permission to quote your manufacturing and other data in our
IND?

Thank you

for your cooperation.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Augwst 5,

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                <text>1968 </text>
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                    <text>August 6, 1968
Dr. Gaston~Germain Trigos

Wyeth Laboratories
Box 8299

Philadelphia, Pennsylvania

19101

Dear Dr. Trigos:

It was a pleasure to discuss studies of WT 3263 and WY 4036.
have had the opportunity to review the data submitted and
believe we can contribute to your study program.

we

4036. These initial reports of this novel compound
report anti-anxiety and anti-convulsant properties. Host unusual
is the report of annesic properties in patients.
NY

of

I reviewed the available

its

EEG

data, seeking a better definition

neurophysiology. Motor activity in mice was suppressed, with
WY 4036
being 100.200 x as effective as chlordiazepoxide. The EEG
activity in cats showed a "decreased frequency and further spindling"
at intravenous doses of l walks to 4 ng/kg. It is reported an
exceptional anticonvulsant, particularly against metrazole.
The clinical data reports ataxia and sedation during administration
of 5-10 mg/day oral, and nervousness, insomnia, diarrhea or constipation
two to three days after cessation of HY 6036.
Two studies are suggested in the population available in these
laboratories.

1. EEG Profile. As indicated, we find the EEG profile
in volunteers, supported by'similar data in patients useful in
classifying new psychoactive drugs, and identifying target populations.
If a parenteral form of WY 4036 is available, an EEG profile study
can be done rapidly, and a suggested protocol is enclosed.

If only

oral form is available, a similar study
it requires more extensive material and a longer
period of study. The protocol indicates the differences in
design in the supplement.
can be done but

an

�‘i

-2~

Dr. Trigos

Clinical

August 6, 1968

trial.

The anti-anxiety activity of
tested in a wide variety of anxiety
subjects. Our ongoing studies of anti—anxiety agents in a
mental health clinic population permit the introduction of
WY 4036 in either an
open study or a random comparison with
chlordissepoxide (our present standard).

2.

WY

4036 should properly be

I would also suggest that a study of the sedative
4036, especially its effects on the sleep EEG
("sleep—prints") be considered. The data cannot be collected
in my laboratories, but we are uniquely equipped to analyze data
recorded carefully elsewhere. The date can be collected in
collaborating laboratories, and if this is of interest, I will
be glad to provide the details.
effects of

WY

—

WY 3263.
The extensive trials already completed are clear
and the new efforts that may be necessary for a better delineation
of clinical applications may come best from the extensive clinical
trials when the iprindole is released. The data does not include
reports of EEG examinations. These would be useful to define the

neurophysiologic basis of the clinical response. In the face&lt;ftthe
extensive clinical data, perhaps such data would only satisfy outﬂw
scientific fancy.
An EEG

may yet be useful in completing the
be assessed in a fashion similar to
can
so,

profile study

submission, and

if

that suggested in the protocol for

WY

4036.

protocols are enclosed, for an EEG profile analysis and
WY 4036.
Protocols for a sleep-print EEG
WY
EEG
4036
and
of
an
study
profile of WY 3263 will be provided.
Two

a

clinical trial of
Thank you

material.

for the opportunity of reading this interesting
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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  </item>
  <item itemId="3469" public="1" featured="0">
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                  <elementText elementTextId="105655">
                    <text>August 5. 1968
Dr. Phi1iip H. Bookman
Department of Medicai Research
Hoffmann-La Roche, Inc.
Nut1ey. New Jersey 07110
Dear Dr. Bookman:
I regret that a satisfactory parentera1 form of R0 5-3350
does not exist, since we are embarking on a project in which
we wi11 have standards applicab1e to the anaiysis of this compound.

indicated during my visit, I am particu1er1y interested
in evaiuating new compounds in order to determine the popu1ation
of choice for c1inica1 efficacy. Perhaps when you or your
associates find another compound that is in the very eariy c1inica1
screening we may have an opportunity to review it with you.
As I

Sincere1y yours.

Fink. M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>August 5 . l968
Dr. McKeen

Cattell

Department of Pharmacology

Cornell University Medical College
l300 York Avenue

New

York. New York l002l

Dear Dr.

Cattell:

I have read and
and Hyams. and find

re-read the enclosed article

it

for publication in its

by Superman

too complex and unfocussed to be suitable
present form.

The authors approach two separate issues - a new mathematical
approach to the analysis of the integrated amplitude EEG. and the
effects of a novel agent. adrenochrome semicarbazone. The
evaluation of this compound is confused by the authors' interest
in the adrenochrome theory of schizophrenia and their observations

that the integrated EEG of schizophrenics is
reaction than like normal EEG.

much

The

article lacks clarity in the

effort could

I follow the

text.

more

like the

LSD

mathematics and only with
The

results presented are
is focussed on

only the mathematical data. but the discussion

the significance of the data for chronic schizophrenia. The
authors suggest that they have additional normal data (to be
published elsewhere) and use it in their argument. but we do
not have the opportunity to examine the data to learn its relevance
to a comparison with chronic schizophrenia (i.e., age, social class,
diet, previous drug history, educational level, etc, of the normal
population).

Finally. the authors fail to present any simple description
of the effects of the drug on the EEG. In view of the importance
of EEG changes for the effectscf psychoactive drugs, it is a
serious omission to find no simple quantitative description of
pattern and frequency effects, activation effects, egg, in an

article entitled as this one is.
I trust these comments are helpful.

Sincerely yours.

J/ézij7/J
nax Fi’nk,

no.

Professor of Psychiatry

�</text>
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                    <text>August 2, 1968
Dr. Ralph Smith

Mayo

Clinic

Rochester, Minnesota
Dear Dr. Smith:

For some time we have been carrying out

EEG

analysis

l800. The studies are primarily psycho~
pharmacological and we are now interested in adding EKG
analysis to determine the changes that may be associated
with high doses of psychoactive drugs.
using a

He

24K IBM

requested the assistance of

that a program for
at your Center. Is
documentation?
Many

EKG

it

IBM

and they indicated

analysis is available for the lane
possible to obtain the program and

thanks.
Sincerely yours.
Max Fink, M.D.
Professor of Psychiatry

MF:kp

its

�</text>
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                    <text>AuguAt 2, 1968

0L. FLLtz FLeyhan

Eston, CompLehenALve PLuehLatLy
3t. Uanent' 6 HOAthaL

neon FLLtz,

I

am

with Lego/cc! to the manuLcLLpt
Mug
ChLoLdLazepodee, aLone and combLned,

"ThLonthane and

Ln

SehLzonhLenLe PatLentL" umLeh you have eonALdeLed (on pubLLcatLon
Ln the jouLnaL. In checthq Lame copLeA Lent to me bu 0L.
HoLden, I 5Lnd that thEAQ have eonheetLon dateL thch nLeeede
the one Lent to uou 60L youL conLLdeLatLon. To avoLd any eLLoL,
I wouLd appLecLate youa estoLLaL aAALLtant cheekLng the capu
Ln noun handL.
0n the Aecond page, we have manhed the dnagt cap”
and the date. The LateL copy, Lon youa conLLdeLatLon, LL
manhed "10- 5— 67". An eaLLLea dhaﬂt, maahed "V: 5- 27- 67" AhouLd

not be

eonALdeLed.

I5 you have the connect capo, pLeaAe dLALegaLd

note. I5 you have the eaLLLeL dnaﬁt, pLeaAe
uuLL bend the Latea dnagt meedLateLu.

at a

LhLL

caLL mu oﬁgLee and we

I LegLet the LneonuenLenee, but a eonthuLng teLatLonAth
mLLeL haL Ltz handLeapA.

dLAtunce 05 1100

SLneeLeLu uouLL,

Max FLnk,
PMOKQLAOk

”.0.

04 PayehLatLq

�</text>
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                    <text>August 2, 1968
Dr. Ralph Smith

Mayo

Clinic

Rochester, Minnesota
Dear Dr. Smith:
For some time we have been carrying out EEG analysis
using a 24K IBM 1800. The studies are primarily psychopharmacological and we are now interested in adding EKG
analysis to determine the changes that may be associated

with high doses of psychoactive drugs.

that

He

requested the assistance of

a program

for

at your Center. Is
documentation?
Many

EKG

it

IBM

and they indicated

analysis is available for the l800
possible to obtain the program and

thanks.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

its

�</text>
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                    <text>August 1, 1968
Mrs. Virginia Hoyle

Assistant Editor

Annuai Review of Pharmacology
4139 E3 Camino Way

Paio Aito, California 94306

Dear Mrs. Hoyie:

Enciosed is our manuscript “EEG and
for the Annuai Review of Pharmacology.

Human

Thank you for the opportunity to prepare
I hope that
meets with your aoprovai.

it

Psychopharmacoiogy“

this

summary add

Sincereiy yours,

Professor of Psychiatry
MF:kp

�</text>
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                    <text>August 1, 1968
Dr. Charles E. Marshall

Associate Director of

Clinical Research
Winthrop Laboratories
90 Park Avenue
New

York, New York 10016

Dear Dr. Marshall:
Some months ago we discussed a study of parenteral
oxypertine in volunteers. I have recently begun such a
study with one unknown compound and it would be convenient
at this time to introduce OXypertine as one of the
experimental drugs.

it

If such
with you.

is possible,

My

I

would be pleased to discuss

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

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                    <text>August
Dr.

Clintin

l,

l968

Brown

Department of Psychiatry and
Behavioral Science
Johns Hopkins University School
of Medicine
Baltimore, Maryland 2l202
Dear Dr. Brown:
I have

recently reviewed the available

methods

for

data and find the literature sparse and
unsatisfactory. While many observers have recommended various
computer methods for the automatic analysis of a sleep record,
these are generally very expensive or insufficient. At the
Society of Biological Psychiatry. Ardie Lubin presented some
data from his program in San Diego based on power spectral
density analysis.
quantifying sleep

My

a

report

EEG

Itil and Shapiro, have written
"sleep prints" based on period analysis.

former associates,

on

Agnew,

Parker.

Webb

and Williams have used amplitude

analysis for the classification of sleep

EEG.

I am confident that you know of others and I am writing
to suggest that the Program Committee consider the possibility
of inviting these workers (anci others) to analyze a tape which
can be sent to each of them and to provide them with an opportunity
to describe their methods, ability to discriminate. expense. egg.
Such an opportunity would be a great help in clarifying
of the problems facing investigators seeking better methods
of quantification. My associates and I will be glad to do what
we can to make such a symposium a success.
some

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: T.

M.

1m. no.

�</text>
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                    <text>August

l,

l968

Dr. Turan H. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Turan,
have modified the laboratory data form to siit some
needs
of this laboratory. We are awaiting a new proof
of the
but I am enclosing a xerox copy of the latest draft available
we

to

me.

This will indicate some of the changes which we have
considered advisable after using the HIP form for the past
few months. These include color divisions between items;

exact values above the place to be marked; the addition of
items for standards. laboratory and route, which we believe

will

be

useful.

on a second form for medical examination
believing that a single sheet on a single side is the best for
and purpose. The laboratory form will be completed by a
We

are working

laboratory technician. We are working on another form to be
completed by a physician and/or technical research person and
this will include such items as weight, blood pressure and skin
and eye changes.
As

soon as a provisional copy

My

best regards.

to you.

is available

I

will send'k

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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                    <text>August

l,

1968

Dr. John C. Kramer

20l9 Camden Street

Riverside, California 92506
Dear John,
good news of your letter of July 14.
have heard of Irvine,
should be a great
university center, especially if some of the dreams of Gerard
come true in the application of computers to education. I would
be pleased to write a letter of reference. Do you want me to
send one spontaneously or shall I wait until I hear from them?
Thank you

everything

From

With a

for the very

it

I

little

luck I will be in Europe from actober l5~25.

Whether I am hate or not I hope that
you will
visit and I will arrange with my
staff to have you entertained and to show you our present programs.

This

may

not

come to pass.
have some time to

T e marijuana problem
a serious one although today
'l5 a UNQQUG day for me. sinceiswestill
did receive 500 mg of tetrahydro'
cannabinol from NIMH. This represents the supply that Jerry Levine
promised last summer. I was also called by Dan Efren who told me
that Aldrich Laboratories of Milwaukee are prepared to produce THC

for qualified investigators.

of the rumors from Washington regarding CNDA
or Psychopharmacolopy. The latest is that Sidney Cohen of Los Angeles
is taking Roger Meyer's place.
I know nothing

also received a large supply (probably
the world's supply) of naloxone for oral use and we will run clinical
trials during the fall.
In

addition to the

I look forward

THC I

to seeing you.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HFtkp

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  <item itemId="3479" public="1" featured="0">
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      <file fileId="5058">
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                    <text>August 1, 1968
Dr. Francis J. Braceland, Editor
American Journal of Psychiatry

l700 Eighteenth St.. N.W.
Washington, 0.0. 20009
Dear Dr. Braceland:

Enclosed are draft copies of two reports summarizing
our experiences with a narcotic antagonist, cyclazocine.
Following theoretical models which have been of interest
for many years, we found that cyclazocine had a neurophysiological profile similar to imipramine. These clinical

trials, in two different populations,
does indeed have significant clinical

indicate that cyclazocine
antidepressant activity.

We are aware that such open clinical studies are
ordinarily of limited value since enthusiasm may effect the

treatment outcome in depressive populations. But the
demonstration of a significant application of available
neurophysiologic methods provides our incentive to present

this publically.
He

and ask

would appreciate your consideration for publication,
that the two reports be assessed together.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc. (2)

�</text>
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                    <text>August 1, 1968
Dr.

Clintin

Brown

Department of Psychiatry and
Behavioral Science
Johns Hopkins University School
of Medicine

Baltimore, Maryland 21202

Dear Dr. Brown:
I have

recently reviewed the available

methods

for

data and find the literature sparse and
unsatisfactory. While many observers have recommended various
computer methods for the automatic analysis of a sleep record,
these are generally very expensive or insufficient. At the
Society of Biological Psychiatry, Ardie Lubin presented some
data from his program in San Diego based on power spectral
density analysis.
quantifying sleep

My

a

report

EEG

former associates,

Itil

"sleep prints" based

on

Agnew,

Parker,

Webb

and Shapiro, have

on

written

period analysis.

and Williams have used amplitude

analysis for the classification of sleep

EEG.

I am confident that you know of others and I am writing
to suggest that the Program Committee consider the possibility
of inviting these workers (and others) to analyze a tape which
can be sent to each of them and to provide them with an opportunity
to describe their methods, ability to discriminate, expense, egg.
some

Such an opportunity would be a great help in clarifying
of the problems facing investigators seeking better methods

of quantification. My associates and I will be glad to do what
can to make such a symposium a success.

we

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: T.

M.

Itil,

M.D.

�</text>
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                    <text>Juiy 31, 1968
Dr. John Biei

Aldrich Chemicai
2371 N. 30th

Company.

Street

Inc.

Miiwaukee. Wisconsin
Dear Dr. Biei:

It was a pieasure to renew an oid acquaintance and
piaased to ask you to provide us with 3 grams of
tetrahydrocannabinoI-A-I (or 9). For our purposes. we wouId
prefer to have this amount made up in ampuies containing
I am

20 mg.each.

We possess Certificate No. 2191 from the Narcotic Control
Bureau and are equipped to carry out research of marijuana as
approved both by the State of New York and the Federai Bureau

of Narcotics.
As

bid which

soon as a

price is determined,

I can submit

I wouId

to our Administrator.

Good iuck and thank you

appreciate

for your assistance.
Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

a

�</text>
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                    <text>F

I'

wee-v.“

an

-

”Liw

July 31,

1968

Ir.

Richard J. Tatham. Chief
Office of Alcoholism and Drug
Addiction Program Development
Government of the District of Columbia
Department of Public Health
Washington, D.C. 20001
Dear Mr. Tatham:

In response to your letter to Dr. Sharoff, I am pleased
to enclose copies of recent reports from this laboratori1which
describe our present program and experiences with cyclazocine.
In response to your specific questions. we have no plans
for the withdrawal of patients from narcotic use on an outpatient basis. The other questions are answered in the articles

enclosed.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
8M: .

�</text>
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                  <elementText elementTextId="105669">
                    <text>Jul y 31. l968
Dr. Ralph Jacobson
Endo
lOOO

Laboratories
Stewart

City,

Garden

New

York

Dear Dr. Jacobsen:
Mr. Kline

delivered the naloxone -

many

thanks.

Dr. Zeks and I are discussing the details of our protocol
and we anticipate the need for placebo tablets at sometime
during the investigation of each subject. would it be
possible for you to supply us with lOOO identically scored

placebo

tablets.

Many

thanks!

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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          <element elementId="50">
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                    <text>July 31. 1968
Dr. Wayne Jostrand
IBM

Corporation

475 Northern Blvd.
Great Neck, New York

Dear Dr. Jostrand:
would appreciate a quotation from
purchase of our installed 1800 system.
We

IBM

for the

Thank you very much.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July 31,

Ir.

Richard

1968

J. Tatham, Chief

Office of Alcoholism and

Drug

Addiction Program Development
Government of the

District of

Department of Public Health
Washington, 0.0. 20001

Columbia

Dear Mr. Tatham:
In response to your letter to Dr. Sharoff, I am pleased
to enclose copies of recent reports from this laboratori’which
describe our present program and experiences with cyclazocine.
In response to your specific questions, we have no plans
for the withdrawal of patients from narcotic use on an outpatient basis. The other questions are answered in the articles

enclosed.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>July 31,
Dr. John Biel

Aldrich Chemical
2371 N. 30th

Company,

Street

1968

Inc.

Milwaukee, Wisconsin
Dear Dr. Biel:

It

pleasure to renew an old acquaintance and
ask you to provide us with 3 grams of
to
pleased
tetrahydrocannabinol-A-l (or 9). For our purposes. we would
prefer to have this amount made up in ampules containing
I am

was a

20 mg.each.

Ne possess Certificate No. 2l9l from the Narcotic Control
Bureau and are equipped to carry out research of marijuana as
approved both by the State of New York and the Federal Bureau

of Narcotics.

As soon as a price is determined, I would appreciate a
bid which I can submit to our Administrator.

Good luck and thank you

for your assistance.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>NEW YORK MEDICAL COLLEGE

NEW‘

FLOWER AND FIFTH AVENUE HOSPITALS

mmommum
CORRESPONDE‘

FIVE EAST IOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

July 19,

1968

Dr. Alan E. Smith
Deputy Director

Division of Anti-infective Drugs
Office of New.Drugs
Bureau of Medicine

Food and Drug

Administration

Washington, D.C. 20204
Dear Dr. Smith:

RE:

IND

2822

The studies Of cycloserine, with or without Dilantin
undertaken at the University of Missouri were completed in
the winter of 1965. Unfortunately, I moved from Missouri
in May Of 1966 and have not had an opportunity to summarize
the infOrmation. I have contacted one of my associates
and asked that the data be summarized.

study was discontinued in the winter Of 1965 and
each
the investigators were notified. The unused supplies
Of cycloserine were discarded in Missouri and are no longer
The
Of

available.

Sincerely yours,

W

Fink,
Professor

Max

Mszp

ﬂimwf‘é’“
M.D.
Of

Psychiatry

3

”Ct:

�</text>
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                    <text>July 19, 1968
Dr.

Ferris

N.

Pitts, Jr.

Department of Psychiatry
Renard Hospital
4940 Audubon

St. Louis, Missouri 63110

Dear Dr.

Pitts:

It was a pleasure talking to you today and in the few
minutes of our discussion, I am sure you saved as three months
of work.

are anxious to replicate your study and would be
grateful for an initial supply of one-half molar sodium
We

lactate.

Our discussion highlighted the many details of this
study which cannot appear in print. would you be willing
to have a member of my staff visit you and observe the
actual administration of these solutions and the details
of the experiment? I would like to send Dr. Michael Taylor

who

is a third year resident undertaking this study.
Incidentally, I will be in St. Louis on Monday or Tuesday,

August 12-13 and

if

we

can arrange a demonstration at that time,

then I can attend as well.
Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>PI?

New Yomc MEDICAL COLLEGE
FLOWER AND Farm AVENUE HOSPITALS
Fwn
I
i N

g;
*1

51'

-

*

.3;
A.

5

(7/

00/9538
”FPO/Pr

EAST IOZND 571112111

NEW YORK. NEW YORK 10029

BPARTMBNT OP PSYCHIATRY

.

Ju1y 18, 1968

Dr. Mer1e L. Gibson
Act1ng Director
D1v1sion of Neuropharmaco1og1ca1 Drugs
0ff1ce of New Drugs
Bureau of Med1c1ne
Food and Drug Adm1n1strat1on
Wash1ngton, D.C. 20204
,

Dear Mer1e,
.

Thank you for your Tetter of Ju1y 15. When we have
supp11es of mar1juana we w111 ava11 ourse1ves of the opportun1ty
to ana1yze representat1ve samp1es. I must te11 you, however,
that we have not been ab1e to obta1n supp11es of mar1juana or
THC from either NIMH, the Narcot1c Bureau or the Narcot1c
Contro1 Comm1ss1on of New York. We have, therefore, not under—
taken any stud1es of marijuana.
The recommended doses

app11cat1on.

for

THC

has been 20

mg

for

»)‘
:“fﬁv~€r

‘

-1

*

~

5I
5:935

131.52:}-f’VLIQ‘EVquthAa'Ly"..,.~‘-."E\;"'}"€.,

each
.
m

Every project 1nc1ud1ng that of mar1juana, THC and hero1n
undertaken at th1s Co11ege has met the approva1 of the Cha1rman
of the Department, the Comm1ttee on Research of the New York
Med1ca1 Co11ege, the Med1ca1 Board of Metrop011tan Hosp1ta1
and the Comm1ss1oner of Hosp1ta1s of the C1ty of New York.
Letters of approva1 are on f11e for mar1juana, THC and hero1n
and cop1es may be submitted on request.

S1ncere1y yours,

W

Max

F1nk, M.D.

Professor of Psych1atry

Mszp

a,

-.»

Ii
.3,
4-"),(66ﬁ'

Minna-:3.

�</text>
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                    <text>July l8, l968
Dr. Norman Pitts
Chas. Pfizer &amp; Co.

Groton, Connecticut
Dear Norman.

but

The second oral doxepin study is now being completed
are in need of additional supplies. Would you please

we

send us:
12

bottles -

l2 bottles

—

per bottle

50 mg

-

lOO

25 mg

—

100 per

bottle

We are actively doing the EEG study as well and have
completed three volunteers. I need a few more in order to
establish a definitive doxepin dosage.

Thank you

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>July l8.

1968

Dr. Merle L. Gibson
Acting Director
Division of Neuropharmacological Drugs

Office of New Drugs
Bureau of Medicine
Food and Drug Administration
Washington. D.C. 20204

Dear Merle,
Thank you for your letter of July 15. When we have
supplies of marijuana we will avail ourselves of the opportunity
to analyze representative samples. I must tell you, however,
that we have not been able to obtain supplies of marijuana or
THC from either Nlﬂh, the Narcotic Bureau or the Narcotic
Control Commission of New York. We have. therefore. not under—
taken any studies of marijuana.

The recommended doses

application.
Every

for

THC

has been 20

project including that of marijuana,

mg

for each

THC

and heroin

undertaken at this College has met the approval of the Chairman
of the Department, the Committee on Research of the New York

Medical College. the Medical Board of Metropolitan Hospital
and the Commissioner of Hospitals of the City of New York.
Letters of approval are on file for marijuana, THC and heroin
and copies may be submitted on request.

Sincerely yours,
Max-Fink. N.D.

Professor of Psychiatry

�</text>
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                    <text>October 28, l968

J. Levine
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Hisconsin
Chevy Chase, Maryland

Dr.

RE:

Dear Dr. Levine:
During

this year

we

have

MH-l33§8~02

carried out nuaorous trials

of drugs in volunteer subjects whom no have paid a fee of
$l0 - $20 each session. The amount allocated for l968,
$1,000 is now expanded. and I am writing to request transfer
of $600 from Parsonnol or Consultation to Out~patient Costs.
This is an internal transfer and will not effect the total
amount of the grant.
This request is approved by the appropriate official of
the College - the Vice President for Government Relations.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

Approved by:

Mr. F. hayden Morgan

Vice Prosident for
Government Relations

�</text>
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                  <elementText elementTextId="105679">
                    <text>E.._w_,._.,__.-__w,.,,m

m

‘v-"m‘mwwvy‘I-wm—vcv

.n- “um

1"va

7..., ~__‘.._,____

ﬁrm—"w.

.

.

VN...V....7...(

”ﬂaw—war

_.

nwv—vv‘h-VV-m.

“WV—wmmw-w

i
F

Octobu 24,

m.

mu

Goa/(3e M. Simpson

HoAthu
sun
New You. 10962

Rocuand
Ouagcbuag,

0m

Gaugc,

m
mm
bun mud
wanting
a
in Mphyuotogy.

Thank you may ranch 604. the.

have

come,
how in Nave-bu

Wt, 05

cum

«the
who

and how.

Since.

ubwty

u

1

:1de
and the. second in AW
two

1969.

van
mm
mu mm.

06 DA. Hana.
bone a the

0m

cannot (and anothu. petition today, I have taken

05 bending he):

Moguooa as Homology wt

Thank you [all

Making

to

DA.

Whoa

06 me.

My yaw,
Fink, NJ).
Magma a5 Poydu‘atxy

Max

HF: hp

be

�</text>
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                    <text>October 21, 1963
Dr. William Tabor
Robins Company

A. H.

1407 Cummings Drive
Richmond 20. Virginia

Dear
1
....:-

w

,
-

.

u"

Tag-,1

1;.

.-'MM?,;~"I:_11..

Bill,

Enclosed are a for capies of our interim report of the
studies of Ropoise (butaperazine syrup) in a group of nonresponsive psychotics in a mental health clinic. Previously
we had sent you the case material, laboratory and clinical
data.

Clare and Simeon to revise this for
publication, and look forward to submitting it either to
Cannon: Thehapoutéc.ﬂeoeaach or the Jouanat 05 New Dnugt.
I have asked Drs.

.

my.

man-1w

e

Separately I have sent to Dr. Owen reports of our studies
with Tybatran. I trust he will share these with you. I have
also completed the protocol for AHR~l900 and this will be sent
to Dr. Clark.
Hy

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry
Max

MF:kp

L
L"-

-

two-.-

�</text>
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                    <text>October 2]. 1968

Sr. Fletcher

Owen

A. H. Robins Company
1407 Cummings Drive
Richmond 20. Virginia

Dear Dr. Owen:
In addition to the study of the effects of beatran
in the treatment of opiate dependence. Br. Sharoff and
Dr. Major assessed its merits in the treatment of withdrawal
from dependence on non~narcotic sedatives. An interim
report of those observations is onciosed as well as a set
of case records. Those are submitted for your information
and I trust that these are helpful.

Sinceroiy yours.
ﬂax Fink. M.B.

Professor of Psychiatry

Mszp
8N3.

�</text>
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                    <text>1

v

:

4

i

A

...

n..."

co.

~—-

-.

.

c

..

October 21, 1958
Dr. J. Levine
Psychopharmacology Research Branch
hetional Institute of Nentel health
5454 Hisconsin Avenue
Chery Chase, Maryland 20203
Dear

Jerry.
I

believe our discussion was most helpful and have
forms requested to Dr. Salzman.

sent the

my files of optical scan rating forms.
copies of the German collaborative forms and
a note that the programming had, as of May, not yet been
accomplished. Our criticism of their form is the high
density packing and the likelihood that machine reading
will be accomplished with difficulty.

In checking

I found my

Sincerely yours.
Fink. N.D.
Professor of Psychiatry
Mex

MF:kp

�</text>
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                    <text>-

-w~

Wru‘ww-a-um

.
«or

WU

31".meﬂ‘¥‘7

October Zl, l968
Dr. Carl Salzman
Program Head

Early Clinical Drug Evaluation Unit
Psychophannacology Research Branch

National Institute of Mental health
5454 Hisconsin Avenue
Chevy Chase. Maryland 20203

Dear Dr. Salzman:
The

data sheets (Biooata 0768) are enclosed and

distributed to the

may

be

program collaborators.
and I do not see the necessity for but have no objection to the
distribution of the HIP laboratory form. but suggest that you

call or.

Itil

Both Dr. Shapiro

ECDEU

for his approval. Additional laboratory data

reports from my files are enclosed. These are derived from
Medical Systems, Inc.. Nathan Kline, Al H. Robins. Geigy
Pharmaceuticals and Sterling—Winthrop.
I look forward to joining you in Miami in December. Since
the principal work on these forms is being done by Dr. Donald
Shapiro, may I suggest that he be invited to participate? As
my travel funds for the year will be exhausted. would it be
possible for your office to support his attendance as a consultant?

Thank you for your kind comments about our
and the copy of the program for Miami.

initial efforts.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>October El, l968

0r. Roland Bonato
The George washington University
Biometric Laboratory

ll45 Nineteenth St.. h.H.

Washington. D.C. 20036
Gear Ron.

It was a pleasure to discuss our interests in the
laboratory data scale. and if the least that was accomplished
was a definition of the need for our laboratory reporting
system. that will have been much.

1px

:',1

12-747mm

'

Enclosed are the figures and a data output from one of
our experiments. The prints reflect the changes in a single
measure over time, with the ordinate being either percent
time (for the individual frequencies). cps (average frequencies)
and relative amplitude. The dev measures are standard deviations.
The abscissa is a number of samples which must be multiplied
by l/3 for number of minutes.

reprint of one of our reports as well as the preprint
of the fenfluramine paper may be helpful in understanding the
The

report.

My

best regards.
Sincerely yours.
Max

Fink. H.D.

Professor of Psychiatry

.

.

.,

Fave-50mm“,

�</text>
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                  <elementText elementTextId="105688">
                    <text>October Zl. 1968
Br. Merle Gibson

Office of New Drugs
Bureau of Medicine

Washington. U.C. 20204
Dear Merle,

It

tor arranging a meeting with Dr. Kelsey.
helpful and we may submit a proposal for FDA

Thank you

was most

consideration.

Enclosed is an additional (copy 3) of the submission
on concentrate fluphenazino hydrochloride. Two copies were
left at your office, and I trust that these are satisfactory.
My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>Octobnr 20, 1968
Dr.

Peta: Singlet

Nationnl Drug Co.

Philadelphia, Pa.
Door Dr.

Singlet,

I have read the doocriptivo material of nlntluino
(RDR 3061A) with considerable interest. It is probable that
we are able to contribute to the evaluation of this compound
and I would like to ask you to visit my loborntory on the
occasion of your neat vinit to Row York to discuss this further.
I an taking tho liberty of uncle-ins a dioouooion
from this laboratory which was pronnntod at the recent wanting
an thioxanthonoo sponnotod by the Quebec Psychophurnacological
Association. It will present our point oi View and suggest
some methods which may ho useful with nlotanino.
Thnnk you

for your intoroat.
Sincerely yours,

Pink, M.D.
Profenaor of Psychiatry

Max

�</text>
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                    <text>October 19, 1958
Dr. Fred Clark, H.D.

A. E. Robins Co.

Richmond, Virginia

Dear Dr. Clark,

Enclosed is a draft copy of a suggested protocol for
the evaluation of AHR~1906. This protoool has been approved
by my staff and has been submitted to the appropriate committees
for approval. I as also enclosing a completed PD 1572, and
supplementary oopies of the rating scales and laboratory data
form to be used.

study should result in a olintcsl report,
analyses of the behavioral changes by the Biometric Laboratory
of NIMH, analyses of the laboratory data by Binders, Inc., and
a summary of the EEG patrorna.
The completed

while
before the
within the next
supplies or for
could arrange a
Earth. I would
study of a long
come

there are some administrative hurdles to be over—
study can be undertaken, I believe it can begin
6 weeks. Before submitting a request for drug
grant support. it would be most helpful if you
visit to these laboratories on one of your trips
also like she opportunity to discuss your suggested
acting fenflursmins.

you have had the opportunity to read this protocol,
would you be so kind as to call my office ? Many thanks.
When

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Mex

nil

�</text>
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                    <text>3..

p—vv—w

October

l8. l968

Dr. Michael C. Barry
Hhite Laboratories
Konilworth, New Jersey 07033
Dear Dr. Barry:

l57l for fluphenazine hydrochloride, oral
lOO mg/ml has been submitted to Br. Merle
Gibson at the Office of New Drugs. Bureau of Medicine.
Copies of the submission and the letter of transmittll
are enclosed.
The FD

concentrate,

Would it be possible to ship one-half the supplies
of the concentrate directly to or. ltil at the Missouri
Institute of Psychiatry (5400 Arsenal Street. St. Louis.
Missouri 63l39)? The supplies for Istanbul should be
shipped to me for transushipment as soon as the proper
clearances are provided.

Dr. Itil Joins me in expressing our gratitude to you
and to white Laboratories for your faith in this preposal
and your diligence in making those supplies available.

Many

thanks.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry
Max

�</text>
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                    <text>October

l4, l968

Sheraton Hotel

Juan,
Puerto Rico
San

Gentlemen:

Please confirm a reservation for one single room
l7~2l, l968. I will be attending the ACNP
for
December

meetings and understand that they have arranged for
a block of rooms at special rates.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>October 14, 1968
Mr. John Haher
Bureau of Narcotics and Bangerous Drugs
633 Indiana, N.W. ~Room 510
Washington, 0.0. 20226

Dear Mr. Maher:
Thank you very much

receive a

letter

for your c00peration.

You

should

from ﬁr. Harold Slumberg of Endo Laboratories.

Enclosed is a capy of the report submitted to us by
Dr. Schwarzkoof regarding the analysis of the heroin recentiy

sent to us.
Again

my

thanks for your cooperation.

Sincerely yours.
Fink, “.0.
Proféssor of’Psychiatry

Max

MF:kp

�</text>
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                    <text>n.

mmwmuw—mnww‘

,
,

October 14, 1968
Dr. Haro1d B1umberg
Endo Laboratories
1000 Stewart
Garden City. New York
Dear Dr. B1umborg:
Enc1osed are cooies of ana1ysos by Dr. Schwarzkopf of
of heroin in Novembor 1967 and again in October
1968. You W111 note that the November samp1e was quite pure
and the October samo1o was the one which I discussed with

a samp1e

you.

I wi11 be very gratefu1 if you wi11 arrange to provide
with 10 grams of pure heroin for our research studies for
the remainder of 1969. Mr. John Haber of the Fodera1 Bureau
of Narcotics expressed the w111ingness to de1iver as much
heroin, simi1ar to that ana1yzed by Dr. Schwarzkopf on
October 7, as may be necessary to produce either 10 grams. or
more than that amount. to permit the Bureau to have some pure
me

supp1ies for others.

Thank you very much

for your cooperation.
Sincoro1y yours.

Fink. M.D.
Professor of Psychiatry

Max

Mszp

"v.

�</text>
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                    <text>October
Dr. Louis A. Gottschalk
Professor and Chairman

hepartnent of Psychiatry ano

Orange County Medical Center
lDl South Manchester Avenue
Orange, California 93668

Human

l4, l968

Behavior

hear Lou,

It is

a

pleasure to submit this

Ur. John C. Kramer,

for

a

letter

on behalf of

position at the University of

California, Irvine, College of Medicine.
I have known John since he was a child, for we grew up in
the some community. His father was a general practitioner and
a close friend to my father; and John was a welcome guest in
our

home .

Following his training as a physician, he joined on at the
Department of Experimental Psychiatry, hillside Hospital. as a
Research Fellow. During the period 1959~l96l he was actively
involved in a comparative clinical. EEG and psychologic study
of chlororomazine, imipramine and placebo; and in the behavioral
and EEG effects of procyclidine. In these studies he accepted

responsibility for the selection of patients. their evaluation
and treatment under "double blind“ conditions. In each. his
activities were carried out with an understanding of the
overall program.

Missouri in l962 I asked him to Join me,
was in the far west. He undertook
felt
when I visited him in l965, he was
and
practice in Albuquerque,
assignments at the neoical school.
his
with
teaching
most pleased
When I

but he

left for

that his future

During the

past two years
discussed his interest in

I met him on numerous occasions and
amphetamines and drug abuse.

In these various associations I have always found John to
be a meticulous. sincere, thorough and reliable coworker. he
is careful and reserved. and not likely to be either aggressive

or impulsive.
and thought.

His contributions are marked by careful effort
His principal interests are clinical and he exhibits

the ability to treat with patience the centally

ill

in his care.

�“" “W

‘

'7' '-'-"-“"‘T'-‘"'-r"r—'~‘~m-'-*-r- ~w—ywq.1v-—n——--w—-m«uww~.~~“him-4;.
-

Dr. L. A. Gottschaik

w

\Vr-(‘~'Vr"w

J; ,

w. ,. ,-

--.r_r._w.,-.r.-

v

».\ _.

__,,V, .u—

7.. . n,

1.."

Wm.

,wwnﬂvmmfp

October 14, 1968

-2—

regret that he was as uninterested in coming to New York
as he was to St. Louis, for when I Joined this faculty in 1966,
I invited him.
I

make

I am

pleased to

contributions as

recommend him

a

scientist

highly,

and

knowing

psychiatrist.

that

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

,r
A

he can

“.17

V.

“m

,5 ,W

�</text>
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                    <text>October 10. 1968
Dr. Kar1 Rickeis

Associate Professor of Psychiatry
University of Pennsylvania Schooi of Medicine
203 Piersoi Buiiding
3400 Spruce

Street

Pni1ade1pnia. Pennsylvania 19104
Dear Kar1.

staff member who heard that
Librium
was 40~50 mg/day, we
the maximum c1inica1 dosage of
instituted a review of our experiences here. It was obvious
that our staff uses higher dosages in our Henta1 Heaitn Ciinic.
Fo11owing the suggestion of a

Before submitting this for pub1ication, I wouio appreciate
your comment, from your experiences with anti-anxiety. whether
this presentation has any merit.
Many

thanks and

my

best regards.
Sincere1y yours,

Fink. M.D.
Professor of Psychiatry

Max

Mszp
8110 .

�</text>
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                    <text>my"

.—

.Nn

”‘5‘

w-

.p

mm

1.,

w

v,-u...y.-u;...«.-.—yi.—.

-

,3

October
Dr. Norman

l0.

196$

Pitts

Chas. Pfizer a Co., Inc.
Groton, Connecticut 06340
Dear Norman.

part of the review of our experiences in the clinical
we have completed this report which may be of
interest to you. especially in interpreting some of the clinical
data in studies using chlordiazepoxide as a comparison drug.
As

doxepin study,

Sincerely yours.
Fink, ﬁ.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>October 10, 1968

ﬁr. Herman Heisman
Hoffmenn~Le Roche, Inc.
Motley,

New

Jersey 07ll0

Dear Mr. Heisman:

Enclosed are two copies of the final draft report. Before
and indeed before deciding whether
to publish it. it may be useful to have comments from some of

revising this for publication.
your associates.
I am

a draft of the proposal prepared by
these experiences. I would also appreciate
as to the feasibility and merit of such a project.

also enclosing

this staff based

your

comments

My

on

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>v.
V.
..
..

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w—kum-v

October

l0,

lBGo

0. Cernora
l432 Glover 5troot
Bronx, New York l0462

Mr. 0.

Dear Mr. Corners:
I wont

you for your
know. without

to take this opportunity to thank

cooperation during our tybamote study.
your heroic efforts. we would not have been able to accomplish
as much as we have. I am pleased to enclose a copy of the
summary

sent to

you

will

You

which has just been completed. A copy has been
The data is confidential and I trust that
communicate this wtthin the A. H. Robins Company only.

report

Dr. Owen.

my

Again.

-‘-v*"-m“vr-rvw

ow

thanks for your cooperation.

Sincerely yours.

Wiv‘m

---'L-~

Max

m‘rl'","mr.1r—

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2va

mm:

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Fink. M.ﬁ.

Professor of Psychiatry

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                    <text>rwr‘u «.-

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g

E

October 10. l968

E

E

s

E

7

E

E

E

é

E

Br. Hilliam Tabor

Robins Company
1407 Cummings Drive

A. H.

Richmond. Virginia
Dear 3111,

We have Just completed this interim report of tybamate.
I have sent copies of the report and case summaries to
Dr. Gwen.

to thank you and the A. H. Robins
in
making this study possible.
cooperation
I want

My

Company

best regards.
Sincerely yours,

E

.

Fink, M.D.
Professor of Psychiatry

Max

“W'KJ‘

W‘Wrn‘m

Intravr'vrj'nw.

xv~._~m.

,

v.

m.

.

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-r....-.-

mmmﬂ‘wﬂn'wrmww'vav

.-.

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for your

.v—unw»

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�</text>
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Dr. Freedman

FROM:

Dr. Fink

DATE:

October

l0,

1968

Enclosed are three recently completed reports for your

information.

MF:kp

6

f’ i)- ’7

5 I“

q‘ 39

Jf— ?— so

D‘f” 7L1
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I
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(1)45

(7-11»)

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                    <text>October 8. 1968
Mr. Edmund Zerkin
PHAHTASTICA

Beloit, Wisconsin

Dear Mr. Zerkin,
We have reviewed the request by Mr. Gemege for the
submission of an original report for the new journal, PHAHTASTICA,
and zigz‘pleased that my associates agree to send you such a report
within the next few months. The report will detail the central
nervous system effects of a variety of hallucinogene, and will
summarize the data presented in a review article I wrﬁte last
year entitled, 'Neurophyaiology of Phenteetica- EEG and Behavioral
Beletione in Men'.

as the

this

It wee striking to us that you selected the same name
title for 1 your journal. An I correct in assuming you obtained

from Levin

The report will probably be 20~25 typewritten pages,
double spaced with 2~3 tables and citation: sufficient to acquaint
the interested reader with the sources used. The major emphasis
will he on our own work.

have asked a young associate of our etetf, Mr. Peter
Irwin, to rewrite the report focueoed on the students who may represent
the major audience of the journal. we would be pleased, of course,
if the report were included in the inaugural issue.
We

reply.

I trust this is agreeable

and

anticipate your favorable
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>-—

October 9, 1968
wg/zwmm‘:~

:4

-.:.a

.7.-

Dr. John A. Clouson

Visiting Professor of Sociology

Department of Sociology
The University of North Carolina
Chapel Hill. North Carolina 275l4
'

Dear John,
The wasting of the APPA Council will be held at 6:30pm,
October 25, l968 at Sun Luck Imperial Restaurant (935 Lexington,
corner 69th and Lexington).
Ho

look forward to having you with us.

Sincerely yours.

mmrhu.nm.
Secretary

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                    <text>rum”

"'mlrv-“wﬂy—arum

-

a... ~v—w.n—-.w~-&lt;

October 9, l968
Dr. Reese T. Jones
Dopartment of Mental Hygiene
The Langley Porter Neuropsychiatric
4Gl Parnassus Avenue
San Francisco, California 94l22

Institute

Dear Reese,

mr—aw

dawn-nwm'

.m—s

Please excuse the delay in answering your letter, but I
that I could handle additional tapes. I believe

had to be sure

that

I can.

1 have read the draft of
your medical student's report
EEG
examined
records carefully. The record of
the
ano
S. Miller showed very little change except in the samples
which follow flashes. But those samples are too short to
be sure.

shows a decrease in alpha abundance
and
an increase in beta and theta activities.
and in amplitude
I read these records before seeing your letter and wonder if
your statement that Shiel's record showed little change may
not have been in error.
The

record of Shiel

-n~—-;;.www.

As I

showed you

at the meeting.

we

are prepared to provide

print-outs of the EEG samples. statistical changes if the samples
are sequential. and figures of the EEG changos for each of the
variables analyzed. The analyses can be either of period or
power spectrum.

Trwvw-ﬂv‘uﬁ‘l'

&lt;

wwnpw

.4-

raw-rarw-nvu-

quality of your paper record is excellent and we will
“artefact” the saMplos during playback. Assuming that you will
provide multiple drug administrations in the same subject and
that you will randomly assign the sequence to take care of
the sequence effect. and. ideally that you will throw away
the first records in each subject. I would ask that there be
a 2 minute sine wave followed by a minimum lo minute resting
record. To maintain a constant state of alertness during this
part of the study. we introduce eye opening every 5 minutes.
The

-

.- ..../-—1-

.

..~.,~

”.3.—

�D" “"95

-2~

October 9, 1968

Following drug administration. at whatever times you
feel the effects are to be measured, we would need a 15 minute
sample done in the same fashion as the pro sample. You may, of
course, record additional 15 minute samples in an experiment
after administration. It may be worth—
at. say, 1 and 2 hours
EEG
while to take an
sample before your interviews. and again,

either after the interview or the flicker experiment.

not know if we can read your tape and would suggest
manufacture
a 10 minute sample with a different frequency
that you
We
read each one and if the frequencies
will
on oath channel.
them
come out as you put
on, then you can proceed. Re are equipped
3
l
back
to play
at 7/8, 3/4. 7 1/2 and 15 ips. Most of our work
1
is at 7/8. I would suggest you record your sample either at
1

this or

do

3 3/&amp;

ips.

that we provide is a “relative“
amplitude. it is important that the calibration signal from an
oscillator go through the EEG and that the settings of the EEG
not be changed thereafter. If you will ”lock“ your calibration
amplitude to some standard, and although it will very, it will
Because the amplitude measure

do so within a narrow range, and thus give you a good amplitude
measure.

for us
itofeasy
the same

to identify samples, we generally
frequency at the end of the experiment
place a signal
1 minute.
then leave a gap of approximately 2 minutes on the
for
tape and begin our next sample with a calibration frequency not
easily related by a factor of 2 to the one before (gég;, 10, 17,
25, 8, 20. £32,).
To make

Incidentally, in reading the medical student's report, it
seems that subject A had no EEG change, D had an intermediate
change and B and C had the greatest EEG change. Hhat were the
behavioral effects Just before and just after the EES samples?
he will begin our THC studies within the next two weeks.
I have not yet received a legal supply of marijuana but plan
to carry out the study anyway. The protocol is being retyped
and I will send you a copy as soon as I have it.

Please send us

a sample

tape and he will proceed from there.
Sincerely yours,
Fink. M.U.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 9. 1968
Dr.

Fletcher Owen

A. H. Robins Company
MO? Comings Drive
Richmond 20. Virginia

Dear Dr. Owen:
As you know. we completed the series of tybanzato studies
in the treatment of Opiate depenuence in July. Enclosed you
will find individual case sumaries and an interim roport
describing our clinical experiences and our laboratory data.
It is out intention to edit this draft and submit it for
publication in an appropriate Journal.
I want

to take this opportunity to thank you and lair. Genera
which this study would not have

for your cooperation. without

been completed.

Sincerely yours ,
Fink, PM}.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 8. l968

Inglis

Dr. James

Department of Psychology

_

Queen‘s University

Kingston. Ontario
CANADA

Dear Dr.

Inglis:

Dr. Dornbush has shared your letter of October 2. Our
study program of unilateral and bilateral convulsive therapy
is in progress. As Dr. Dornbush may have told you. we have
a wide experience with a variety of treatment methods.
Your

letter suggests that

applying [CT and

be of

interest to

available.

that

you have

us to read

you may have a new way of
written a review. It would

this review, if copies are

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

HF:kp

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                    <text>October 8. l968
Dr. James Mortal
Squibb Institute

New

for

Medical Research

Brunswick. new Jersey

Dear Dr. Martel:
an experimental supply
x lOOO. He are maintaining
approximately thirty patients on depot Prolixin and now
are introducing a number of patients with a two week
May

I

request. once again.

of Prolixin tablets.

1

mg

trial of oral Prolixin.
Thank you

for your cooperation.
Sincerely yours.
Fink. M.D.
Frofcssor of Psychiatry

Max

MF:kp

�</text>
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Inglis

Dr. James

Department of Psychology
Queen's University
Kingston. Ontario
CANADA

Inglis:

Dear Dr.

Dr. Dornbush has shared your letter of October 2. Our
study program of unilaterai and biiatera] convulsive therapy
is in progress. As Dr. Dornbush may have told you, we have
a wide experience with a variety of treatment methods.
Your

letter suggests that

applying
be of interest
avaiiabie._
ECT

you may have a new way of

that you have written a review. It woulo
to us to read this review, if copies are

and

-

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 8, l968
Dr.

J.

M.

C. Holden

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Mike,
I have just read your laboratory data scale report to
the Amehican Jounuaz oé Psychiattg and reureed the butaperazine
study in the June issue of Cunnent Thenapeutte Redeaech.
Both are contributions to clinical drug evaluation programs.
and you should arouse considerable interest.

appreciate reprints of both reports. and would
ask in addition that you send me 6 extra copies of the AJP article.
I would

It

are able to read
the data sheets. and I anticipate that you will get some
inquiries. You should know that the MI? program does not
allow for the coding of drug and dosage - these must he added
by hand - and the range of values to be coded is not clear
from the printed form. The dependence on the instructions
leads to coding errors which are expensive to correct.
was kind

of you to indicate that

we

As improvements. we have recently reprinted the form.
making some additions and clarifications. It may be helpful
to send cepies of this form to the enquirers. and for this
purpose I am enclosing a supply. In addition, since you

wish to send copies of the outputs to some who are
interested, there are included samples for this purpose.
he are prepared to read both the HIP and the new form.

may

Keep up

the good work!
Sincerely yours.

'4'.

_,.~,.,

Fink. M.D.
Professor of Psychiatry

Max
I’vw-w-u-MW-rw,

I'V.7:VVW-W"r

at“;

MF:kp

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                    <text>October 8, 1968

Director of Medical Research
Parke. Davis Co.

Detroit, Michigan
Dear

Sir:

We have recently read the report by Smith and Weyl in
Current Therapeutic Research, descibing their study of Zerontin
in the treatment of children with brain dysfunction. We are
establishing a psychophermscology resesrch unit addressed to
children end adolescents in conjunction with the ongoing ECDEU
progress in sdisophrenie. depression and narcotic addiction, end
are interested in the possibility of undertaking e trial similar
to that described by Smith and Weyl.

we would be grateful if s representative of the
medical reseerch department could either cell or visit us, to
tell us the status of the studies of this compound; and the
other studies which way be in progress to confirm these inter~

eating observations.
Thank you

for your cooperstion.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>-:

‘erwvxmwn‘l'r-w-Tw aw

v 1-.

'VIA%.,'"-Muwti'“'-w~n-—uw‘.«_~rrams-1‘"

“nu-2.x.” ..—r 1/.»

v

71‘

.77

~

'&gt;~wl---"

,

“&gt;31 w.

..~v.;

.._v—~.v..m_

«”1. .mi. -...—,._

s

,

.S.

October 2, 1968
Dr. Norman Weiss

Chairman, Program Committee

Queens County Psychiatric Society
109-10 Queens Bivd.

Forest Hi11s,

ﬂew York 11375

Dear Dr. Heiss:
Thank you very much for your invitation. I wou1d be
p1eased to address the Queens County Psychiatric Society

on Tuesday

evening,

November 19.

I wou1d iike to describe recent experiments in the
treatment of various types of menta11y i11 in e commuiity
mente1 hea1th center, emphasizing the use of new drug
forms. p1ecebos. antagonists in narcotic addiction, and
the treatment of acute1y disturbed users of he11ucinogens.

For a tit1e I wouid suggest either “Psychopharmaco1ogy
in a Community Menta1 Hea1th Center“ or "He11ucinogens.
Tranqui1izers and Psychotropic Drugs of the “705."
I 100k forward
and time.

to hearing

from you regarding p1ace.

Sincereiy yours,
Max

Fink. H.0.

Professor of Psychiatry

Mszp

.... V...,.f..s_,

“ ,m
v

.

.

,._,.

v

.,,

,7

is,

V

H

�</text>
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              </elementText>
            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="35262">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="35263">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
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                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="84289">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="90850">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="97411">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
