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                    <text>April 30, 1968

m. Charles Slugass
Temple University
Dewar-ant of Psychiatry

Philadelphia, Punnsylvania

Dear Charles,

It was a pleasure having you meet with tha residents
Wissufﬁcienttoooverthemanyﬂﬂngsyoubought
andtohavespentmtimewithyouinSpain. Ihopethe
Claraduringtl’ntrip.
Many

than!
Simemly yours,
Fink, M.D.
Professor of Psychiatry

Max

Hfzkp

�</text>
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                    <text>.
—

w“

~.-»-

A.

r1

r’v..V'—n—vr‘4vn’,—

)w-n'l

April 30. l968
Dr. Morris 8. Bender

East Shore
Kings

Road

Point,

New

York llOZ4

Dear Morris.

It

was a great pleasure to read the announcement of your
I know that your many students will be as
new appointment.
gratified as I that recognition came to you in the form that
did ~ a rostrum from which you can lead many other young

it

students into neurology and research.

Congratulations and my best wishes for success of your
ﬂepartment and the New Mt. Sinai School of Medicine. Please
also extend my regards to Sarah.
Sincerely yours.

“WWWW,~'_F

Fink, M.D.
Professor of Psychiatry

Mex
,....,.

MF2kp

�</text>
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                    <text>April 2n, 1968
Dr. Stanley Feldstein

The Willian Manson Whita
20 West Vuth Street
New York, New York

Institute

Dear Stan,

MyoufwtmcurﬁvulunvitaeofGailAlbem. I

donottmnkthisreoomﬁeﬂectswhatImlooldng for.

I did

send

My

it

to

Roy John however.

best regards.
Sincerely yams ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April l8. 1968
Dr. Gerald L.

Klemn

Associate Professor of Psychiatry
Yale University School oi Medicine
333 Cedar Street
Haven. Connecticut

New

Dear Berry,
Enclosed

visit to the

is a check for your expenses in your recent

New

York Medical

College. Again

my

thanks.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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Dr. Jonathan 0. Cole

Superintendent
Ecston State Hospital

Boston, Massachusetts 02124
Dear Jonathan,

Enclosed

visit to the

is

a check for your expenses in your eecent
Medical College. Again, my thanks.

New York

Sincerely yours,
Fink, M.D.
Professor of Psychiatny

Max

MF:kp

enc.

�</text>
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                    <text>April

l5, l968

Dr. William Karliner

Franklin Road
Scarsdale. New York
20

Dear 8111,
A

repeat

EEG

was done on Miss

Harriet Bernstein

on April 4,

According to your note she has been receiving
Dilantin 400 mg. Tofranil 100 mg and Vivactil 20 mg/day.
(#409-M).

This record shows spontaneous seizure activity, high
voltage persisting for one to three seconds. The waves are
high voltage 3 to 4 per second with intermittent single spikes,
amplitudes exceeding 250 microvoltsJiith hyperventilation end
the seizure activity is enhanced. The background record is
filled with S to 7 cps activity with superimposed l8 to 24 cps.

is

In comparison to her

earlier records seizure activity
activity slower.

more prominent and the background

Im ression: This combination of drugs does not ordinarily
produce seizure activity. although reports of such activity after
imipramine are available. These reports are primarily in patients
with a seizure history.

The experience of seizures after convulsive therapy is
I would believe that such seizures would decrease with time

limited.

if

they are related to the induced convulsions. with these ideas
in mind. I would suggest that Hiss Bernstein’s seizure activity
is probably related to a process other than the induced convulsions
and also other than her present drug treatment.

�Dr. Karliner

~2-

April l5. l968

If her behavioral state has improved, then perhaps these
drugs should be discontinued. If she still is depressed, than
they probably should be continued despite the EEG record.
I

Thank you very much for the opportunity to see her again.
look forward to seeing you at Gracie Square.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
P.S. Dr. Paul Blachly is visiting me on Saturday. Mayll I
understand this is your usual working day and perhaps you could
set aside a few minutes to chat with us.

�</text>
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                  <elementText elementTextId="102555">
                    <text>January

ll,

l968

Dr. Francis Latteri, Chairman
Pharmacy Committee

Metropolitan Hospital
97th Street and

New

York,

Dear Dr.

New

First

York

Avenue

Latteri:

During the past few months, patients of the Mental Health
have received medication not prescribed or amounts that
were insufficient to provide for the time between visits from
the pharmacy at Metropolitan HOSpital. Such events were occasional
early last year but have become increasingly frequent.

Clinic

some

would

Also, the staff of the Department of Psychiatry have reviewed
of the newer dosage forms of established pharmaceuticals and

like to

May I

and would

agenda?

recommend

that these

be made

available.

inquire as to the next meeting of the Pharmacy Committee
be possible to have these two items placed on the

it

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>h

April i2. l968
Dr. Carl Salzman
Program Head. ECDEU
Psychophanmacology Research Branch.
5454 Wisconsin Avenue
Chevy Chase, Maryland

NIMH

Dear Dr. Salzman:

recently returned from a visit to Istanbul where
I have monitored our studies of butaperazine and high dose
fluphenazine. The studies are going remarkably well and the
'ease with which the data has been collected has stimulated
me to write to you.
The present climate for new drug studies is becoming
stonny as I and some of the other ECO U workers find the
. I believe there
FDA regulations increasingly restric
H. Denber, Don
ECDEU
as
group
are other members of the
who
have
an interest in international
Gallant and Burt Schiele
be
would
uaeful
to arrange a discussion
studies. Perhaps it
which
representatives of hdustry may
of our experiences to
be invited, so that this avenue of drug evaluation may be
opened. There are problems, for example. the acceptability
I have

of foreign data to the FDA. However. I think the advantages
of this work outweigh the handicaps and a discussion may serve
a useful public purpose.
I look forward

to seeing

you in June.

Sincerely yours,
Fink, ﬂ.D.
Professor of Psychiatry

Max

Hszp
cc:-

Dr.

J. Levine

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                    <text>April 12, l968
Mr. Henry L. Giordano
633 Indiana Avenue, N44.

Hashington, 0.6. 20226
Dear Mr. Giordano:

.

'

writing to request the Buroau of Narcotics make
available to this Department of Psychiatry an additional
Z'grams of heroin HCl. (recryStalized) to continue our ongoing studies of antagonists in the treatmEnt of narcotic
addiction. I have called Dr. Eddy and he has suggested
that I write directly to you.
I am

i

A

similar supply

was made

available to us (Dr.

A.N.

Freedman, M.D., Chairman of the Department of Psychiatry)
on November l3. 1967.
Thank you very much

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: Supervisor 6. Belk
Dr. N. Eddy

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                    <text>:7“.

April

ll.

##1va

l968

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
3l3l S.H. Sam Jackson Park Road
Portland. Oregon 9720l
Dear Paul.
Thank you

comparing

ECT

for your letter of April 4.
electrocardioversion.

and

and the

reprint

For your visit on May ll. we can arrange to meet you at
Gracie Square Hospital (76th Street and York Avenue) at l0:00 a.m.
on Saturday, May l. If you will let me know where you are staying
my associate. Dr. Richard Abrams. will be glad to pick you up and
bring you to the hOSpital. He can visit there and observe the
treatment program and i would then like to have you visit our
laboratories at the Medical School. while I cannot guarantpce,
a demonstration. i may be able to show you enough to make the

visit

worthwhile.

The program of Drs. Dole and ﬂyswander is the best program
for narcotic addicts in the city,(and possibly in the country)
and you should visit. Their principal center is at Beth Israel
Hospital which is at lath Street and Second Avenue. 1 would
suggest you write directly to Drs. Dole and Nysuander. indicate
your interest and your earlier experiences with addicts, tell
them of your invitation to visit our laboratories and ask for
an opportunity to see the Bernstein Pavilion on Saturday afternoon

or Friday evening.

A

visit

Your question about a
rings no hell with me. for

compounds.

should be very much worthwhile.

new beta adrenergic
I have not studied

Both Dr. Abrams and I look forward

blocking agent

it or similar

to your visit.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc:

Dr. Abrams

53%

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                    <text>May

2, 1968

Mr. Lee Hanna

Director of

News

HCBS-TV

518 West 57th St.
York, New York 10019

New

Dear Mr. Hanna:
wouid appreciate a print of fi1m No. 24556, 1abe1ed
"anti—narcotic" as prepared by Mr. Ear1 Ubi11 and the staff
He

of

NCBS~TV.

understand there wi11 be a charge for this prind:
and I am prepared to reimburse WCBS as suggested in my
discussion with Mr. Eari Ube11's secretary, Miss Heckman.
We

We

wou1d be very

gratefui

if this print

avai1ab1e before May 9,
a specia1 1ecture on May 10.
Thank you

which wou1d

cou1d be made
permit us to use

it

for your assistance.
Sincere1y yours,

'

Mszp
cc:

Mr. Ube11

Fink, M.D.
Professor of Psychiatry

Max

in

�</text>
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                    <text>May

2, 1968

Dr. James Bailey

Foundations Fund for Research

in Psychiatry

Street

lDO York
New

Haven. Connecticut

Dear Dr. Bailey:
During the past two years I have participated in a collaborative
study program with the University of Istanbul in the evaluation of
new

psychotropic drugs in the treatment of the mentally

initial results

have been encouraging and we would

these studies since they provide opportunities to

ill.

like to

test

Our

expand

hypotheses

which may not be practicable in the United States. For example,
we have just completed a high dose and very high dose fluphenazine
study, to test the recommendations of some French scientists.

In discussing our program with Dr. Jonathan 0. Cole, formerly
of the Psychopharmacology Research Branch of NIMH, he suggested
that I write to you to inquire whether the Foundations Fund might
consider an application on behalf of such a study program.

principal investigators in

such a program would include
Director of the Division of Psychopharmacology.
Missouri Institute of Psychiatry (St. Louis) and Professor Necmettin
Polvan,]Chairman of the Department of Neuropsychiatry, University of
The

Professor Turan
stanbu

M.

Itil,

.

Thank you

for your interest.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>April

ll .

1968

Dr. Tito B. Dinzey

Administration Hospital

Douney Veterans

Denney. North Chicago,

Illinois

60064

Dear Dr. Dinzey:

Hhile I regret the delay. I have finally obtained
permission to consider appointing an internist to the

Department

W)..-

.
1%.

w

w

.A,

staff.

I would

like to

have you

visit

us

at

our expense and ask that you call my secretary collect
at (2l2) 369~8488 and work out a time that is mutually

satisfactory.

,..-

Thank you

I
~

for your interest.

Wﬂm~sp

Sincerely yours .

.,,.,.,,_.._,,,,.

7

Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                  <elementText elementTextId="105603">
                    <text>April 10. 1968
Dr. Edward Gendel

Director Cytogenetics Laboratory
Metropolitan HoSpital
—

First

1901

New

York,

Avenue

New

York

Dear Dr. Gendel:
I have

Just received

a carbon

of your

letter to

Dr. Freedman.

I had asked Dr. Bucci to indicate to you that the procedure
to be followed in undertaking such a study would be to provide
a protocol, in sufficient detail to be acceptable to the Research
I asked Dr. Bucci to assist you and
Committee of the College.
I trust that he has been able to do so. since chromosome changes
with drugs is an important scientific and political issue.

Controls for drug intake, illness and age should be included
in the design.

letter of April 8 does not, in my opini
e
criteria for the Research Committee

Your

minimum

of Hospitals.
and

if

Department

I ask you to please meet with Dr. Bucci again
you need additional assistance, please have him call on me.
May

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr. A.

M.

Freedman

�</text>
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                    <text>April 10. 1968
Dr. Roger Mayer

National Institute of Mental Health
Bethesda, Maryland
Dear Dr. Meyer:

last week of

permit for
marijuana study, we prepared the enclosed protocol for study
of marijuana and tetrahydrocannabinols. This protocol has been
approved by the Chairman, Dr. Alfred M. Freedman and will be
submitted to the appropriate comittees of the College.
Following the receipt

a Federal

Hhile MH—l3358 (EEG and Human Psychopharmacology) provides
funds for the EEG aspects of this study, additional funds are
necessary and a proposed budget in the amount of $43,360 for

direct costs is enclosed.

will

be determined

appropriate indirect cost rate
we are prepared to submit
be required to undertake the study

An

administratively.

such additional data as
as a contract.

may

that supplies of marijuana. THC-A-l
and possibly THC-A~6 will be made available by your office. The
laboratory and clinical facilities are equipped to undertake this

It is

our understanding

study immediately and
Thank you

we

would request support

effective July

for your cooperation.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

l,

1968.

�</text>
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                  <elementText elementTextId="102563">
                    <text>April 12, 1968
Or. Francis Latteri. Chairman
Committee on Pharmacy and Formulary

'

l East 105th Street

New

York, hen York l002‘9

Dear Dr.

Latteri:

At a meeting on April l, of the Psychopharmacology
Study Group - a committee of the Department of Psychiatry

«

four compounds were recommended for inclusion in the pharmacy.
These compounds had been requested by members of the staff.
They include flophonazino onanthata, haloperidol. thiothixene

and tybamate. The Committee‘s recommendations have been approved
by the Chairman of the Department. Dr. Alfred M. Freedman.

Fluphenazine enaothata was recommended for admission of
a new drug to the formulary. for use limited to the Department
.

of Psychiatry.

lhe other three compounds were recommended for

trial periods of 6 months and that the manufacturer be requested
to mate trial supplies available to the pharmacy.
If these recommendations are approved by the appropriate

committees of the hospital. I would be pleased to arrange with
the pharmaceutical concerns involved to make the supplies

available to the

pharmacy.

‘

Sincerely yours .
Max-Fink,

m.

Professor of Psychiatry

HF:kp

cc: Mrs. Cruzado

�</text>
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              <elementText elementTextId="33423">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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  <item itemId="3343" public="1" featured="0">
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                    <text>April 10, 1968
Dr. Merle Gibson

Director ~ Division of Neuropharmacology
Office of New Drugs - Bureau of Medicine
Food and Drug Administration

Washington, D.C.

Dear Dr. Gibson:

In resoonse to suggestions of the

NIMH

that studies of

marijuana and the tetrahydrocannabinols be expanded, we would

like to undertake the studies described-in the attached protocol.

I have received Federal Tax Stamp M-l27 of the Federal
Bureau of Narcotics.

and
.

It is

my

understanding that

this is enclosed.

To avoid

a FDA—l57l should be

filed,

duplication, pennission has

received from Dr. Jerome Levine (Psychopharmacology Research
Branch, NIMH) to refer to IND 302~l, assigned to NIMH. A
letter from them to you has been requested.

been

These studies will be undertaken in the laboratories and
clinical facilities of the Division of Psychophannacology,
Department of Psychiatry, New York Medical College - Metropolitan
Hospital Medical Center by myself and the associates responsible
to me. Form l572 will be completed wherever indicated.

�Dr. Gibson

We

April 10, l968

~2-

have been assured that supplies of marijuana and the
be made available by the NIMH and/or the Federal

extracts will

Bureau of Narcotics.

This study is planned for one year, but
l8 months from its initiation.
I

may

extend over

trust the enclosed data is satisfactory.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>April 10. 1968
Dr. Jerome Levine, Chief
Psychopharmecology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase. Maryland 20203
Dear

Jerry.

I have obtained a tax stamp for marijuana studies from
the Federal Bureau of Narcotics. and am proceeding with the

F.D.A. and with Dr. Roger Meyer.

The F.D.A. has requested a letter of authorization to
pennit them to refer to your data on file (see letter enclosed).
Copies of the letters from Drs. hartin and Isbell pennitting
use of their IND are enclosed.

copy of the proposed protocol is enclosed for your
information. To provide the clinical personnel specially
required for this study, we are submitting a “contract“ request
to Dr. Roger Meyer, following suggestions received by Dr. Freedman.
A

we will be able to initiate the study in mid-May if we
receive approval from the appropriate College committees and
supplies from NIMH. For thirty trials with THC~A»1 at 300y/kg

(20 mg/dose) we will need up to 600 mg. Can this be made
from your office? Is marijuana “leaf“ available
from your office or should I call the local office of the
Federal Bureau of Hercotics?

available

'

will call your office as soon as
Thank you for your guidance.
I

I

receive approval here.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp '_

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                    <text>April 8, l968
Dr. Samuel Bogoch
36 The Fenway

Boston, Massachusetts 022l5
Dear Dr. Bogoch:
.

Thank you very much for sending me a copy of the preliminary
announcement of the next international conference of the Sakel
Institute. You are to be congratulated on assembling such a

fine

list
I

of scientists.

would be

if

you would send such

additional

available for this meeting. as
like to attend with some of my associates.

information

would

grateful

as may become

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

I

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                    <text>April 8. 1968
Dr. Fletcher 8. Owen.
A. H. Robins Company
l407 Cummings Drive

Jr.

Richmond, Virginia 23220
Dear

0r.

Owen:

Enclosed are the forms you requested, which I understand
will be filed with the FDA.

patients are confirmed.nercotic addicts with extensive
It is difficult to know whether their reports are more
or less reliable than the.chronic schizophrenics usually studied.
The report by Shelton and-Hollister reflects studies done in
Veteran Administration patients - a group of chronic mentally
ill repeatedly hospitalized and usually inundated with psychoactive drugs. In our patients, we have symptoms reported but
I would not quote these as drug withdrawal until we have studied
Our

drug use.

this further.

These patients who have told us of using narcotics while
taking tybemote report an increase in the “narcotic high.“
do have not observed this ourselves and until we administer
heroin challenges to subjects under our observation, I would
not wish to quote this observation.

Sincerely yours,
Fink, M.D.v
Professor of Psychiatry

Mex

MFtkp

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                    <text>April 8, 1968
Dr. Jonathan 0. Cole

Superintendent

~

Boston State Hospital
Boston. MasSachusetts 02l24
,

Dear Jonathan.

invitation to discuss convulsive therapy with the

Your

residents has inspired
the citations that

me

I would

to review my files and to consider
suggest for background reading.

The best texts are those of Kalinowsky and Hoch (Somatic
Treatments in Psychiatry. Grune and Stratton, l96l) and

..

-

.

'7'

.r~--¢.m.w.-1.;,

_,,

Sargent and Slater (An Introduction to Physical Methods of
Treatment in Psychiatry. williams and Wilkins. l964).

is a list of citations which assess some of the
in convulsive therapy. The list is not
issues
important
exhausted and I have selected the article for clarity. No
Attached

effort has

been made

to

be complete.

I am sending you xerox copies of each of the
this may be useful for the residents.

Separately,

articles

and

I plan to arrive at your hospital about 10:30 a.m. and
would be pleased to spend some time with Dr. Hartmann.
Your comments about the review of EEG and drugs are cogent.
0n reureading I agree that this is too much of a summary and a
longer version should be prepared. I would like to discuss
this with you when I am in Boston.
I look forward

to seeing

you next Wednesday.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>April 8. 1968
Dr. William Tabor

A. H. Robins Company
l407 Cummings Drive

Richmond. Virginia 23220
Dear

Bill,

I have been reviewing the initial data in the elixir
butaperazine study. I cannot recall
you had indicated
have
a desire to
the
twenty cases reported in a special

if

first

format. Is there a record fonn for these cases that you

would wish us
Many

to use?

thanks.
Sincerely yours,
Fink, M.0.
Proféssor of Psychiatry

Max

MszP

�</text>
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                    <text>April 8. 1968
ﬁr.

H. P. Colvin
Burroughs uellcome
l Scarsdale Rd.

Tuckahoe.

New

&amp;
'

Co., Inc.

York l0707

Dear Dr. Colvin:
We are continuing our study program of long
acting
flupnenazine enanthate (Squibb). Our experiences with the
initial 80 subjects has encouraged us to continue as the
treatment is acceptable to patients and appears to be as
effective as oral phenothiazines.

Approximately half our patients are taking antiparkinson medication and while we have recently obtained
supplies from the hospital. I would be grateful if you could
make available to us another shipment of 25000 tablets,
Kemadrin. 5 mg.

._

,

Thank you very much

far your cooperation.
[Sincerely yours,
Fink. M.B.
Professor of Psychiatry

Max

MF:kp

�</text>
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                  <elementText elementTextId="102569">
                    <text>April 8, 1968
Mrs. Nina Hethlson
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Nina,
I have

appreciated receiving the citations from the

Project. So-far, my principal criticism would be that
many articles are sent from journals which I regularly read
and this duplication may be expensive. Perhaps, in future
systens a check could be introduced not to send certain
SDI

c

tat ens.

‘

other group of citations which are of less
interest are those related principally to studies in animals.
The only

I have examined

assigned to

profile.

my
. 38 and 41 may be
applicable to my
Many

the

list

of

new concept numbers and

I would suggest

deleted. This will

present interest;

make

that

numbers

the profile more

thanks.
.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

those

la, 32,

�</text>
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                    <text>April 8, 1968
Dr. Francis

Latteri,

Chairman

Cami ttee on Pharmacy and Fomulary
l East 105th Street

New

York.

Dear Dr.

New

York

Latteri :

associates and I have reviewed the requested application for admission of a new drug to the Formulary, meclizine
My

hydrochloride.
The

literature indicates that this compound has specific
which no other compound is readily available.
is recommended.

indications for

Approval

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 2,.1968

Ir.

Thomas Lewinson

Research Division

Hoffman-LaRoche

Nutley.

New

Jersey

Dear Mr. Lewinson:
e cony of our latest report. He are encouraged
the discrimination of EEG patterns
continue
to
by this
to
of new drugs
identify their preper clinical applications.

Enclosed
work

is

grateful for copies of the reports
recently written.
I would be

you have

7

Good luck

at the

BIA

Meeting.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Mex

Mszp

‘

�</text>
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                    <text>April 1, l968
Dr. William R. Tabor
A. H. Robins Company
1407 Cummings Drive

Richmond. Virginia 23220

Dear

Bill,'

Enclosed is a summary of a demonstration experiment with
fenfluramine (your study 2063) undertaken with second year
medical students at the New York hedical College on January 9
and 10, 1968.

-

The students participating on January 9. volunteered for the
experiment and the data is enclosed. On January lo the students
requested that the experiment not be undertaken since they were
scheduled for examinations beginning January ll. and they had
heard from the first group that some subjects had difficulty
in sleeping. For this reason only 1/4 the number of subjects
actually took the drug.
'

This was my first.experience in a student demonstration
project. For these young men_end women the anxiety of a novel
experiment, in a group setting with much interaction seemed to
so alter their responses that neither amobarbithl nor
dextroamphetamine gave a well defined response. The only
change which may be related to drug effect was the decrease in

digit

symbol score

for amobarbital.

The remaining supplies of fenfluramine are being sent. as
requested to Mr. Collins. The form for Disposition of Investigational

Drugs

is enclosed.

I want to thank you for your cooneration in
which was most enlightening. My best regards.

this study

Sincerely yours,
Pink, ”.9.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 1, 1968
Dr.

J. Hittenborn

Rutgers - The State University
Brunswick. New Jersey

New

Dear Dick.

Enclosed is the original and one xerox copy of the
Behavionaz
report "Neurophysiology of Phantastica. EEG andACNP
in
Rotations in Man.? This was presented at the

Puerto Rico and is the third for which
I

trust that this

with your approval.
who was

My

responsibie.

has not heid up pubiicetion and meets

sent
session.

I have

Chairman of the

I was

a copy

to

Dan

Freedman,

best regards.
Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Hex
MF:KP

�</text>
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                    <text>July 30. l968
Dr. Nathan B. Eddy
7055 Wilson Lane
Bethesda, Maryland 20034
Dear Dr. Eddy:
We

have

recently

been assured by Endo Laboratories

that naloxone will be available this week for clinical
study. We anticipate doing multiple challenges on each
subject and will require an additional supply of heroin
for this purpose.
Our present supply will be exhausted

August.

I would be

avmwvw'.

.

available an additional
is practicable.
Thank you

m:

an-

v

A-mW‘IJnI"

p.
t-rr

~

Mn’wm—avvu

‘u‘i‘

.
7

--,

a“"'a'—‘v'trl"mnrjrra

._.,

would arrange

to

make

grams of heroin as soon as

for your help.

Fink, M.D.
Professor of Psychiatry

Max

V:w.._..,_,.,,.,,.a

.m—wu

if you

5

end of

Sincerely yours.

,,.,

mar—.7“...

grateful

at the

MF:kp

�</text>
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                  <elementText elementTextId="102575">
                    <text>July 23, l968
Dr. Nathan S. Kline

Director of Research
Rockland State Hospital

Orangeburg,

New York

Dear Hate,
Thank you very much

for the lecture to the residents.

Enclosed is a small honorarium.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                  <elementText elementTextId="102576">
                    <text>July 23, l968
Dr. G. B. Blane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons. Ltd.

Hull. England

Dear Dr. Blane:

of the MAS-NRC Committee
just read the l968 report
reference to the
on Problems of Drug Dependence and note
meeting,
narcotic antagonist M-SDSO. As we presented atin that
treatment
the
we are particularly interested in antagonists
I have

of opiate dependence.

data is
Has M-SOSO been assessed in human trials? If the
we
are particularly
available, I would appreciate a citation. since

interested in its duration of action.

are supplies available for
If it has not been assessed,
clinical trial or will they be available in the near future?

are interested in making such assessment if supplies
with
could be made available. since we already have experience
cyclazocine and naloxone.
Sincerely yours,
We

Fink. M.D.
Professor of Psychiatry

Max

mf:kp

�</text>
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                    <text>July 22, l968
Mr. John

J. Bellizzi, Director

Dear Mr.

Bellizzi:

Bureau of Narcotic Control
855 Central Avenue
Albany. New York 12206

is a copy of our Federal Tax Stamp. Class 5 4 and 5 narcotics. The suggestion in your
June 21, that we apply for a class 6 (marijuana)

Enclosed

marijuana and

letter of

does not apply to us since

we

are not millers.

I trust that these registration stamps are sufficient
to comply with the regulations.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>v—wq.':WmF-.

.

«mwﬂ-‘qw

~7un-

.

v'quw'

ran-n

July 19. 1968
Hr. Nathan F. Williams
The Blue Line Chemical Company
302 South Broadway
St. Louis, Missouri 63102
Dear Mr..Williams:

Following our discussions today I am writing to request
your estimate for supplying 50 one liter sterile bottles of
one-half molar sodium lactate. After discussion with the
author of the enclosed paper, Dr. Pttta, the calcium chloride
is not prepared ahead of time, but will be added here. We,
therefore, need only the one-half molar sodium lactate.
Enclosed is a copy of the report.
our reference.
Thank you

Please see page

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mix

two

for

w.mn—

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                    <text>July 19, 1968
Dr. Alan E. Smith
Duputy Director

Division of Anti~infectiv¢ Drugs
Office of Now Drugs
Bureau of Medicine
Food and Drug Administration
ﬂushington, D.C. 20204
Dear Dr. Smith:
The

RE:

IND 2822

studies of cycloaarina, with or without

Dilnntin
undertaken at the University of Missouri were couyleted
in
the

winter of 1965. Unfortunately, I moved from
in May of 1966 and have not had an opportunity to Missouri
summarize
the information. I have contacted one of my associates
and asked that the data be summorizod.
The

study was discontinued in the winter of

1965 and

each of the investigators were notified. The unused
supplies
of cyclosorine were diocarded.in Missouri and are
no longer
available.

Sincoroly yours,
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>~

July 19,'1968
Dr. Merle L. Gibson
Acting Director
Division of Neuropharmacological Drugs

Office of New Drugs
Bureau of Medicine
Food and Drug Administration

washington, D.C. 20204
Dear Merle,

I want to thank you for the cooperation which you have
expressed on behalf of the FDA to Endo Laboratories regarding
naloxone. In a meeting with one of their vice presidents
last week, we were assured that supplies of naloxone would be
made available for clinical trial early in August.
I

writing to ask your advice on another matter. In
investigated the effects of intravenous procyclidine
in patients receiving convulsﬁye therapy.' Recently
in response
to suggestions from NINE, I have reestablished a study program
am

1956~58 I

in convulsive therapy. It seems advisable to repeat some of
the observations made earlier and to build on that
With this in mind, I called Burroughs Wellcome and experience.
requested
a supply of parenteral procyclidine, since such is not listed
in the PDR. Dr. William Calvin indicated that the IND for
parenteral procyclidine was withdrawn and supplies of parenteral
procyclidine were no longer available but could be produced.
When I asked that he do
so, at our expense, he indicated that
this was not possible insofar as the IND had been withdrawn.
are the steps necessary for me to meet existing FDA
and to permit Burroughs Wellcome to supply parenteral
procyclidine for experimental use in a project approved by the
appropriate authorities of the college, NIMH and the City of
What

regulations

New

York.

Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

.

»,~—.-7,.,,,,

va—

�</text>
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                    <text>July 19, 1968
Dr.

Ferris

N.

Pitta, Jr.

Department of Psychiatry
Renard Hospital
$940 Audubon

St. Louis, Missouri 63110

Pitts:

Dear Dr.

pleasure talking to you today and in the few
minutes of our discussion, I am sure you saved us three months
of work.

It

was a

are anxious to replicate your study and would be
grateful for an initial supply of onenhalf molar sodium
We

lactate.

discussion highlighted the many details of this
study which cannot appear in print. would you be willing
to have a member of my staff visit you and observe the
actual administratiOn of these solutions and the details
of the experiment? I would like to send Dr. Michael Taylor
who is a third year resident undertaking this study.
Our

Incidentally, I will

August 12-13 and

if

we

be in St. Louis on Mbnday or Tuesday.
can arrange a demonstration at that time,

then I can attend as well.
Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>.

:2‘

.Yw

-

mg

”-1

,_

we.

was“... “aw—g.

mam...r..r-qp.~u

v,‘&lt;’vw

vvu'v‘u» ..,;w-‘.-:~ ~.....nw.m.

-

.1,

“-7".

V

,

-,

-,-.v~»-..v,n..

., .,

“WV/wt MW. .w“,,___,. ”W,

,

.

.e.

July 18. l968
Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New York. New York
Dear Alain,
I enjoyed lunch very much and I hope that
under such pleasant circumstances more often.

in

Enclosed is

"A

we

can meet

Selected Bibliography of Electroencephalography

Psychopharmacology" which was published in 1964.

Human

It

is the definitive supplement to the first bibliography wtitten

by Mary Brazier and covering the period l936-50.

of Phogeeaa in Baain Reacaaeh.
This
was organized by Phillip
symposium
”Anticholinergic Drugs.“
and myself and the major portion of the editing of documents was
undertaken in my office. This symposium was the second which I
organized on the same subject. The first is published as part of
volume Advances in Biologioaz Paychiateg edited by Joseph Hortis,
the
966.
I am

also enclosing

Volume 28

interested in the tremendous value of
depot phenothiazine therapy, not only in treating chronic mentally
ill but in relieving acutely disturbed patients in a community
mental health center. If I can made a contribution to this
subject by assisting in the publication of the available data.
As

you know, I am

I would be
My

pleased to do so.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp
one o

7”

�</text>
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                    <text>Juiy 18.

1968

Dr. Alfred M. Freedman
Chairman of the Department

Department of Psychiatry
York Medics! Coiiege

New

5

East

New

102nd

York,

New

Street

York 10029

Dear A1,
I am pleased to send you this volume
“Antichoiinergic
Drugs” recently puhiished by Elsevier. This
was
heid in 1966 but most of the editing was done symposium
in New York.
My

thanks again

far your support.
Sincerely yours,
Max

Fink, M.0.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>awn-mu».

~.Jv“'&gt;'.1'"nr,wv

vim].

.,.-.-_~

.—

..
w ma n max,'wr rx w w v..- . —:~(:.n-. '1' m-v- Wm nun-I“.
W‘wa a-wrw-u‘uninn-IVAan‘I'Vwmru'ﬂw'vaW-eanw"“wart-'0’”
.

V

,

“we“;

v

.._

_

July 18,

1968

Dr. Charles Shagass

Eastern Pennsylvania Psychiatric Institute

Henry Ave. and Abbottsford Road
Philadelphia. Pennsylvania 19129
Dear

Charlie,

of the work reported in this volume would not
have been accomplished without your faith and support.
Please accept this copy as a token of my esteem.
Much

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
CDC

.

�</text>
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                    <text>July l8,

1968

Dr. William Guy
George Washington University

Biometric Laboratory

6l8
ll45 Nineteenth Street, N.".

Room

Washington. 0.C. 20036
Bear

Bill,
Separately I

sending you the additional forms for
our ketimipramine (060l0) and butaperazine (06007) studies.
am

recently received one box of the
global scales. No second box was received.
We

have

We

are now using
that you send

and ask

September.

CG!

(l2)

form 03 (treatment emergent symptoms)
us 200 now and 200 additional in mid-

May we also have 200 copies of the Hamilton Scale (form 08)
and an additional 100 of form 12.

Sincerely yours,
Max

Fink,

M.D.

Profestor of Psychiatry

Mszp

�</text>
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.7... mm

--—.m,n..ur-m

w&gt;nm Jun awnmf, uuw

.-

,

-

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M‘va

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,

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.

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July l8, 1968
Dr. Lothar B. Kalinowsky
ll5 East 82nd Street
New York, New York l0028
Dear Lothar,

Please accept this copy of "Anticholinergic Drugs."
This symposium was presented in Washington in l966 and
it represents a useful portrayal of our available knowledge.
from

The
NIMH

convulsive therapy project has received support
and I look forward to our continued collaboration.

Thank you

for your assistance.

My

best regards.

Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp
ENC .

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                    <text>July l8, l968
Dr. Robert L. Kahn

Associate Professor
Department of Psychiatry
University of Chicago Hospitals and Clinics
950 East 59th Street

Illinois

Chicago,

60637

Dear Bob.
The program of research in convulsive therapy is now
in Gracie Square Hospital. 1 have two resident
progress
physio ans working with me and a fine experimental psychologist.

in

I would like an opportunity to have you meet with my
staff and to discuss their programs. Do you expect to be
in New York within the next two months? If not, would you
like to come on a visit and we will defray the necessary

expenses.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July l8,

1968

Dr. Samuel Irwin
Professor of Pharmacology

Department of Psychiatry
University of Oregon Medical School
3l8l s.w. Sam Jackson Park Road
Portland. Oregon 97201
Dear Sam.
Your nephew has been working with me for more than onehtlf year and I want to thank you for sending him. He has
learned rapidly and is an asset to our program.
I plan

to be in Portland forea drug problem

session on August l4~15.

I

will probably arrive

and would welcome an opportunity to meet with you
evening of the l3th or on the l5th.
I may

bring Peter to keep

him

summer school

on the

either the

out of mischief.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

l3th

�</text>
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                  <elementText elementTextId="102585">
                    <text>July 18.

1968

Dr. Joseph Zubin
722 West l68th Street
New York, New York l0032
Dear

Joe,
Thank you

for the

copy of the

APPA

program.

My nomination for the Hoch Award is Martin Roth of
Newcastle. For at least two decades he has been a leading
figure in attempting clarification of psychopathology. He
has written on a broad spectrum of subjects and in this

regard is quite similar to Paul Hoch.

Sincerely yours.
Fink,
Secretary

Max

MF:kp

M.D.

�</text>
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                    <text>July l8. l968
Dr. Paul Blachly

Associate Professor
University of Oregon Medical School
3l81

5.“.

Sam

Jackson Park Road

Portland, Oregon 9720l
Dear Paul,

for your kind invitation to participate in
the summer school. I know that you will be busy, but if
you are planning to treat patients any day that week other
than Wednesday, I would like to make arrangements to be in
Portland to, once again, watch the treatment administration.
Thank you

I

look forward to seeing you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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,

4.3.2:

7..

wnw—Wuvv-wvo—mr

wwvunmhwm~www-wu

'

nu..-

w-m

“Wm!"wmm'

.7

w m,

.V'x-n—E‘QWvn,

July 17, 1968
Mr. Herman S. Heisman

Senior Reeearch Associate

HoffmanneLe Roche. Inc.
Hurley, New Jersey 07110
Dear Mr. Heisman:
my

associates

and a revised capy

review

and

I have reviewed the pronosed protocol

is enclosed.

this, please call

laboratory.

my

When

secretary

you have had a chance to
and arrange to visit the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 16, 1968

J. Robinson
Hoffman-La Roche, Inc.

Dr. R.

Nutley,

New

Jersey 07ll0

Dear Dr. Robinson:

It was a pleasure to visit your laboratories, and I am
most grateful for the courtesy and attention shown me by
Dr. Whitman and his associates. I am impressed with the
was of value to me to meet Dr. Schallek and
programs and
see his program in action. The EEG methods of analysis of
psychoactive drugs for applications in man has been of
Special interest to me. and I will review the data of
R0 5-3350 with the probability of undertaking a neurophysiological profile analysis in normal volunteers. We
are prepared to cooperate with Dr. Schallek in the analysis of
some of his data should he wish to do so.

it

it is

taking advantage of our short acquantance,
a ridiculous problem which you and the
laboratories at Hoffman-La Roche may be of assistance. The
neurophysiology of narcotics has become a recent interest,
and the problem of marijuana and tetrahydrocannabinols has
been an open question since the first studies of Williams et‘gl.,
in l946. We are equipped to do detailed analyses in man, But
have been unable to obtain a legal source of marijuana or THC.
The recent report of Schekel and his associates indicates that
but

THC

Perhaps

I am

faced with

was produced by your

laboratories.

consider the production of THC for our use?
the necessary Federal and state permits for testing
and handling marijuana; an IND from the FDA; and protocols
for studies have been approved by the appropriate committees
of the medical school and by the Commissioner of Hospitals
of New York.
Would you

He haVe

�v
Dr. R.

J.

Robinson

-2-

July l6,

1968

If such a production is possible. I would be anxious to
discuss the costs and the necessary clearances from the appronriate
Federal authorities with you.
A

recent review of the studies of

for your information.

EEG

and drugs

is enclosed

Many thanks for your consideration and again, for the many
kindnesees of your staff.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

cc: Dr.

E. Whitman

Dr. C. Scheckel
Dr. A. M. Freedman

enc.

�</text>
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                    <text>July 16,

1968

Dr. Ardie Lubin

Research Psychologist

Navy Medical Neuropsychiatric Research Unit
San Diego. California 92l52

Dear Ardie,

It

was kind

of you to send

me

the preprint of your

effort in discriminating sleep stages. It represents

latest

much work

to read it. since I have just
revised the paper of our period analytic approach to the same
problem, following some suggestions from the editors of the
EEG Journal.
The revised version is enclosed and represents much
of the data from the Missouri laboratory, exce t that there are
additional tables such as you request spage l6§ describing the
relation of the computer classification to the visual by the
trained observers. This data is being prepared for another
publication. but I am sending your preprint to Dr. Itil with a
request he share the data with you for inclusion in your report.
and I appreciate the opportunity

I am impressed by the portrayal of the power spectral density
approach, especially by the complexity and by the implicit expense.

difficulties

which you describe - difficulties which are described
this approach. and also found by ourselves - are
the lack of discrimination of small differences in this method.

The

by others trying

Perhaps the lack of discrimination is related to the paucity of
samples for study ~ if I understand, you analyzed l8 selected
minutes of an all night sleep recording. This small sample is
related to the cost of power spectrum.

That PNRS shows good discrimination among sleep stages by
the delta band, the unimportance of theta, the significance of
alpha and sigma, and the difficulties of discriminating stage I
from stage I-REH and stgge 3 from stages 2 and 4 are the same
problems we faced in power spectrum. Additional discriminations
are possible in period analysis. for the stage I - stage I-REM
discrimination is now available; the stage 3 discrimination is
feasible following your suggestions (page l8) and some of our own.

�Dr. Lub1n

Ju1y 16, 1968

-2—

Some of the
I agree w1th your conc1us1ons (page 17).
recommended add1t1ona1 data 13 ava11ab1e or 15 read11y
programmab1e us1ng per1od ana1yt1c and the d1stance funct1on

‘

approaches.

Perhaps the t1me has come to compare the ava11ab1e methods
for systemat1ca11y co11ected data. As I 1nd1cated ear11er, we
are prepared to ana1yze tapes us1ng the per1od ana1yt1c methods.
We wou1d be spec1a11y 1nterested 1f they are a1so to be ana1yzed
by)our methods. The costs 1n do11ars and t1me are negot1ab1e
and shou1d compare favorab1y w1th the expense and delays wh1ch
you descr1bed for your present systems.
Such ana1yses cou1d be done as part of a demonstrat1on for
an APSS meet1ng and as the bas1s for a d1scuss1on of the ava11ab1e
methods. If th1s is not feas1b1e, we wou1d st111 be w1111ng to
cons1der a demonstrat1on for you at a cost that 15 comparab1e to

that of Astropower.

It was a p1easure to hear your report 1n Wash1ngton, and to
read th1s prepr1nt. Perhaps the enc1osed report W111 perm1t you
to be more opt1m1st1c about th1s rea1—t1me (or 2-4x rea1 t1me)
ana1yt1c system for the re11ab1e and automat1c scor1ng of EEG
sleep stages.
My

best regards.
S1ncere1y yours,
/ﬂax F1nk,

M. D.

Professor of Psych1atry

Mszp

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                    <text>July 15, 1968
Mr. Jerome serchuck

Ends Laboratories
1000 Stewart
Garden City, New York 11533
Dear Mr. Serchuck:

our luncheon on Friday, and I want to thank you
was
for the candor and the fine cooperation sf Ends Laboratories which
assessment
expressed. we look forward to the opportunity to continue the
of naloxone, and hope that such studies will improve the present care
provided these mentally ill.

I very

much enjoyed

presentation and the attitudes expressed suggest, regrettably,
has
that an adversary relationship, rather than one of cooperation,
denands
that
developed. For my part, I must apologise for my demands,—
in
program
study
experimental
maintain
an
desire
to
are expressed in a
and
Federal
by
and
State
support
continual
which
justification
man
requires
to a maintenance
authorities. We see the ready acquiescence of the community
drug treatment model (as the enclosed report indicates), and regret that
The

this is occurring without sufficient independent extensive testing.

that some of the problems in the evaluation
active consultations between industry and
the clinicians. My suggestion is for an active collaborative relationship,
so that the course of this complex program may be optimised. Such arrangements
between industry and the academic community are not novel and may be useful

The essence of my argument is
of naloxone may be averted by more

here.

thanks for a most pleasant luncheon and for the assurance of
continued supplies of naloxone.
Again

my

Sincerely yours,
max

Fink,

M.D.

Director, Division of
Psychopharmscology

Mrzkp

cc: Alfred M. Freedman,
Max Beltand, M.D.

M.D.

one. (2)

P.S. I am enclosing a recent review of the EEG studies of psychoactive
Dr. Dunn and consider such
drugs. Perhaps you may share thishewithalready
doing these in St. Louis
is
Perhap.
gtudigg formplindOne.
or Princeton.

�</text>
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                    <text>July l5, l96a
Dr. S. Clyde Strickland

Merck Sharp and Dohme

Point, Pennsylvania l9486

West

Dear Clyde,
and

I would be grateful for supplies both of benactyzine
parenteral ngentin as I am reviewing studies of the

convulsive therapy process in
Would you

man

and animals.

please supply the fellowing for

human

36

-

2

cc ampules Cogentin each containing 2 mg.

lOO

-

1

mg

tablets Suavitil for oral use.

For our animal studies is it possible to get
benactyzine powder without filler?
Again,

my

100 mg

thanks for your cooperation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

trials?

of

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                    <text>July 10, 1968

Ir.

Gerald Drew
Department of Pharmacology
University of Tennessee
Memphis. Tennessee 38103
H.

Dear Mr. Drew:
Dick has asked me to send you a copy of the revised
cyciazocine report. This has been sent to the Society of
Biologicai Psychiatry to be published in Recent Advances in
Biological Psychiatny edited by J. Wortis.

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

4

MF:kp

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                    <text>July 10. 1968
Dr. Alexander

Suite 6l7,

M. Don

Pan

Africa House

Cor. Jeppe a Troye Streets
Johannesburg. South Africa
Dear Anyy,

stimulated to review this report on LSD by our
discussion. I have had it retyped. Unfortunately, I cannot
find’the references in any of the cepies in my file. I also
feel that the report is less sophisticated in its review of
LSD on psychotherapy than the recent literature allows.
I was

Would you

find the time to add the references and review

as much of the recent
I would be

literature as is available to

grateful for your

comments.

My

you?

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc ;

�</text>
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                    <text>July l0. l968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Turan.
I have read the enclosed preprint by Lubin 3; gL.and
written the enclosed letter to him. I had seen this
report in Washington and encouraged him to send it to me
since he seemed to minimize the possible applications of the
period analytic approach.

have

you can send him (or me. if you wish) some of the
you made up of the relation of the visual and computer

If

tables

scoring of sleep records, the data may help to modify his
present lukewarm View of the period analytic method.

I have offered to analyze some of their tapes.
especially if they are willing to report the data of comparable
analytic methods to the APSS since I am confident that the
programs will match up favorably, and I am sure that they
can afford to pay reasonable consultation fees since they

are paying such

new

to Astropower.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July l0, l968
Dr. Ardie Lubin

Research Psychologist

Navy Medical Neuropsychiatric Research Unit
San Diego, California 92l52

Dear Ardie.

It

was kind

of you to send

me

the preprint of your

effort in discriminating sleep stages. It represents

latest

much work

it, since I have Just
revised the paper of our period analytic approach to the same
problem, following some suggestions from the editors of the
EEG Journal.
The revised version is enclosed and represents much
of the data from the Missouri laboratory. except that there are
additional tables such as you request (page l6) describing the
relation of the computer classification to the visual by the
trained observers. This data is being prepared for another
publication, but I am sending your preprint to Dr. Itil with a
request he share the data with you for inclusion in your report.
and I appreciate the opportunity to read

I am impressed by the portrayal of the power spectral density
approach, especially by the complexity and by the implicit expense.
The difficulties which you describe - difficulties which are described
by others trying this approach, and also found by ourselves
are
the lack of discrimination of small differences in this method
except at a great expense in either time or dollars or both.
—

That PHRS shows good discrimination among sleep stages by
the delta band, the unimportance of theta, the significance of
alpha and sigma, and the difficulties of discriminating stage I
from stage I-REM and stage 3 from stages 2 and 4 are the same
problems and the same discriminators we face in period analysis.
Some additional discrimination: are possible in period analysis,
for the stage 1- stage I-REM discrimination seems now to be
working; the stage 3 discrimination is feasible following your
suggestions (page 18) and some of our own.

�Dr. Lubin

July l0, l968

-2—

conclusions (page l7). Some of the
data is available or is readily
programmable using period analytic and the distance function
I agree with your
recommended additional

approaches.

Perhaps the time has come to compare the available methods

for systematically collected data.

As I indicated earlier, we
to
are prepared
analyze tapes using the period analytic methods.
We would be specially interested if they
are also to be analyzed
by our methods. The costs in dollars and time are negotiable
and should compare favorably with the expense and delays which
you described for your present systems.

Such analyses could be done as part of a demonstration for
an APSS meeting and as the basis for a discussion of the available
methods. If this is not feasible, we would still be willing to
consider a demonstration for you at a cost that is comparable to
that of AstrOpower.

It

was a

My

best regards.

pleasure to hear your report in Washington, and to
Perhaps the enclosed report will permit ou
to be more optimistic about this real-time (or 2-4x real time
analytic system for the reliable and automatic scoring of EEG
sleep stages.
read this preprint.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>July 9.
Dr. Joyce 6. Small

Clinical Director of Researhh

1968

and

Laboratories
Larue 0. Carter Memorial Hospital

l3l5 Nest lOth St.
Indianapolis. Indiana

46207

Dear Joyce.
You

are correct.

changes in laboratory
and a cooy of the

My

associates

and I did measure the

test data during out drug study program,

report is enclosed.

Since completing that study we have become even more
concerned that any drug study should have concurrent laboratory

controls since established textbook figures are inaccurate

when

applied to an individual institution. We have designed a
laboratory form and set up programs for the analysis of the
data. Our first results were quite good, but we learned that
some corrections should be made in the form itself and we have
involved a private consulting firm in New York to revise our
data analysis and provide the results not only for ourselves
but for other institutions that may be interested. In the
event that Biodata Inc. can interest some of the pharmaceutical
concerns collecting data from various centers to send them the
data sheets then a central bank of laboratory results, hopefully
both for drug data and for placebo control will be available

for analysis.
A

be

copy of the MIP form is enclosed and the new one
you when it is available.

sent to
My

will

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>July 9, l968
Mr. Thomas M. Colasuonno.
Alcohol a Drug Education

The Western

Institute of

Summer School

Director
Drug Problems

P. 0. Box l491
Portland, Oregon 97207
Dear Mr. Colasuonno:
weeks ago we responded by sending a copy of my
curriculum vitae and photographs to Mr. Don Short. In
response to your recent request, I am enclosing a short
autobiography and a copy of my complete curriculum vitae
for your use.
Some

Since the presentation will be a summary of our experiences
during the past few years and an overview of the work of others,
no formal paper

is available.

To supplement my remarks, I am

enclosing copies of publications and preprints recently completed
in this department which will be the basis of the presentation.
The focus of attention will be on the problems of narcotic
antagonists in the treatment of opiate dependence and the most
relevant material is summarized in the preprint “Antagonists in
the Treatment of Opiate Dependence" and "Narcotic Antagonists
and Substitutes in Opiate Dependence.“

like to arrive

a day or two prior to the actual
appreciate a copy of the announcement of
the Institute and a suggestion as to the nearest motel accommodations.
As

I would

presentation.

I would

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>July 9, l968
Dr. Joyce G. Small

Clinical Director of Researhh

and

Laboratories
Larue D. Carter Memorial Hospital
l315 West lOth St.

Indianapolis, Indiana

46207

Dear Joyce,

are correct. My associates and I did measure the
changes in laboratory test data during out drug study program,
and a capy of the report is enclosed.
You

Since completing that study we have become even more
concerned that any drug study should have concurrent laboratory

controls since established textbook figures are inaccurate

when

applied to an individual institution. We have designed a
laboratory form and set up programs for the analysis of the
data. Our first results were quite good, but we learned that
some corrections should be made in the form itself and we have
involved a private consulting firm in New York to revise our
data analysis and provide the results not only for ourselves
but for other institutions that may be interested. In the
event that Biodata Inc. can interest some of the pharmaceutical
concerns collecting data from various centers to send them the
data sheets then a central bank of laboratory results, hopefully
both for drug data and for placebo control will be available

for analysis.

copy of the MIP form is enclosed and the new one
be sent to you when it is available.
A

My

will

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>y .~

,_..

7

rmu—rmm.

as- "w:»m__s.mﬂw.ra—-Wrmmrww-«we-mm

-.-—~—w---.—&lt; .—

July 8,

‘

~-

-.

-wm—mwn.-.mw

-—.,—w "a. -.—-r-.—rvw—Wm..........____,.,r.._...,_,_“W...

_,__

Mwﬂum

1968

Dr. Jack D. Barchas

Asst. Professor of Psychiatry
Stanford University School of Medicine
Stanford Medical Center
Palo Alto, California 94304
Dear Dr. Barchas:

is

It

Membership in the American Psychopathological Association
of members and election at an annual meeting.
is the custom of the membership committee to ask members for

by nomination

their recommendations in the fall of each year.

Earlier editions of the monographs published by the Association
contained lists of members. If you would check this and request
a member to submit a nomination this might be useful to the

membership committee.

Sincerely yours,
Max

Fink, M.D.

Secretary

Mszp

�</text>
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                  <elementText elementTextId="102597">
                    <text>July 1. l968
Mr. Donald Cheetham

Smith Kline a French Laboratories
1500 Spring Garden Street

Philadelphia, Pennsylvania
Dear Don,

a Departmental meeting, the protocol of the study,
“Combined MAO Inhibitors and Chlorpromazine Therapy" was
reviewed. as well as the recommendation that we file an IND.
In view of the objections raised, we decided not to file such
.At

an

application at this time.
Thank you

for your cooperation.
Sincerely yours,
Fink. I.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                  <elementText elementTextId="102598">
                    <text>June 28, 1968
Dr. T. P. 8. watts
Donwood Foundation
175

Brentscliff

Road

Toronto, Canada
Dear Paddy,

I am pleased to enclose
have
some reprints of our work with narcotic antagonists. I
one
useful
most
model
is a
been impressed that the antagonist
encouraged
to
been
for the treatment of addiction and have

It

was nice

talking to

continue this area of study.

you and

If

you have the opportunity to

narcotic addicts, in addition to treating some with
methadone, you might consider treating others with cyclazocine.G.
This can he obtained on an experimental basis from Dr. Joseph

treat

some

New York 12144.
Bird, Sterling-Winthrop Research Institute, Renaselaer,
Unfortunately, I have no experience with the treatment of
methedrine addiction, but will probably begin with fluphenaaine.
in high doses.

Thank you

for your assistance.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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"u"

r-n.

v

June 28, 1968
Dr. Jerome Levine
Peychophermecology Research Branch
National Institute: of Mental Health
5454 Wisconsin Avenue
Chevy Cheee,‘Merylend
Deer

Jerry,

Enclosed are two reports describing the EEG profiles
of psychotropic drugs which have recently been completed

with the support of MH-lSOOB and 13358. These are being
considered for publication by Dan Efron in the proceedings
of the ACNP. 1967.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex
MF;kp

�</text>
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                    <text>June 27, 1968

Jr., Director
Narcotic Addiction Control Commission

Mr. Louis E. Moon,

Executive Park South
Stuyvesant Plaza
Albany, New York 12203
Dear Mr. Moon:
The

following is in answer to your inquiry of June 21, 1968.

TR-34: This form is completed when a patient is admitted to
Metropolitan Hospital for detoxification and additional treatment.
TR—33: Completed when patient is either discharged against
advice, or discontinues the aftercare program by not returning
within a month of the date of visit or completes a period of inpatient and out-patient care and we have decided that no further
treatment is necessary.

Treatment completed implies that no other services in

institution are

deemed

useful for the patient.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kp

cc:

Mr. Schwartz

this

�</text>
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                    <text>"—

,w-

.mu—u

.v
.r'wr

"var-s»

‘I-u-

June 27, 1968

J. Fitzgerald, Jr.
District Director of Internal

Mr. Edward

120 Church Street
New York, New York
Dear Mr.

Revenue

Fitzgerald:

Please send us the necessary forms to register in Class 6 Herihuene, so that we can fully comply with the request of the
Department of Health of the State of New York.
Sincerely yours,

:“W

M
w.

~5th

.

Hex Fink, Md).

Professor of Psychiatry

Hrzkp

�</text>
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                    <text>Jun: 27, 1968
Dr. Alfred M. Freedman
Departnont of Psychiatry
Now York Medical College
5 East 102nd Street ‘
new York. Now York 10029
Door Dr. Froednan:

writing to rocommcnd the nomination of Dr. Charles F.
Stroebel for membership in the APPA.

I

am

I have known of his work sine. 1962 when he came toHe tho
had
Inctituto of Living from the University of Minnesota.
Hillside
boon rccommonded by Gordon Heistad for a position at
Hospital but I could not arrange this, although I wanted to,
since I

knew

I

was leaving.

Dr. Stroebol has done many fine studies in neurOphyaiology,

specifically in the area of diurnal rhythms. He has fine computer
experience and is an excellent statistician.
I would be pleased to have him participate in the meetings

-

A

.

of tho

4-

‘

APPA.

Sinccrely yours,

~1-rr-Iyuorxiu».v.-

Fink, ﬁ.D.
Professor of Psychiatry

Max

Hrzkp

cc:

-

.

.

.
.

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31$.

r”:

lnxwgmvk

Dr. Gluock

�</text>
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                    <text>June 26, 1968
Dr.

J.

S.

Gottlieb, Director

Lafayette Clinic
951 E. Lafayette

Dttroit, Michigan

48207

Dear Jacques,

It

of you to send me the latest review of the
of
schizOphrenia. The findings do fit together,
present theory
and I am impressed that the data is also consistent with other
evidence not included in the review.
was kind

Many

studies suggest that the

EEG

patterns of schizOphrenics

are different from other populations — in greater degrees of
desynchronization and beta activity, and in an enhanced response

to intravenous barbiturates. That these observations are rarely
confirmed may relate to the variability of the presumed permeability
changes you postulate (as well as the invariable differences in
techniques).

theory is also consistent with the differences in EEG
responses to psychoactive drugs among schizophrenic, depressive
and normal populations, with the schizophrenic populations showing
a more rapid and/or excessive response.
The

»r
9‘:
w‘,

,
2:.

uwuwfq

Again, my thanks for a fine report; and my added admiration
for the 12 year review which accompanied it. As one who tried to
establish a stats-based research center and failed, your success
in asking the Lafayette Clinic the outstanding center that it is

bespesks an unusual

Hy

congratulations.

political

acumen and a hulldogged determination.

1,7,.“-

Sincerely yours.

,v

5"}..r;

was

as;

tun—7r.»

,

Fink, M.D.
Professor of Psychiatry

Max

.._

,.

"3“?

.a‘x

'7':va

WY”.

Emma;

MF:kp

�Dear Jacques,

It

was kind

of you to send

me

the 1atest review of

the present theory of schizophrenia. The findings do
I am

impressed that the data

fit

together,

a4zoL

the-

iéjgonsistent with other evidence not

inciuded in the review.
Many

studies suggest that the

EEG

patterns of schi20phrenizs

are different from other popuiations-- in greater degrees of desynchron-

ization

and beta

activity,

and in an enhanced response

to intravenous

barbiturates. That these observations are rareiy confirmed

reiate

may

variabiiity of the presumed permeabiiity changes you postuiate[4/v
44-ﬁ1,u40ﬂw,.,/e.
agjﬁ
x7yuyt,,, fa, franu.differences
.
The
aiso
to the

theory is

consistent with the

in

EEG

responses to psychoactive drugs among schizophrenic, depressive
and normal
a more

popuiations, with the schizophrenic popuiations showing

rapid and/or excessive response.
Again,

for the

thanks for a fine report; and

it.

year review which accompanied

12

estabiish

my

a

state-based research center

and

As

my

added admiration

one who

tried to

faiied, your success

in making the Lafayette Ciinic the outstanding center that

s

4,,

it

is

bespeakd an unusuai poiiticai acumen and bu11dogged determination.
My

congratuiations.

m,
72%

�</text>
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              <elementText elementTextId="97276">
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                  <elementText elementTextId="105614">
                    <text>June 26, 1968
Dr. Melvin Therner
Schering Corporation
Bloomfield, Rev Jersey
Deer Mal,

is a preprint of the initial report on the high
dose fluphenazine study as presented at the CINE meeting in
Enclosed

Tarragona in April.

I am also enclosing a xerox copy of the letter from the
British Medical Journal. I believe that these experiences

do support the merit of a very high dose fluphenazine study.

As I indicated at the ECDEU meeting, Dr. Barry of White
Laboratories called me last week to state that they have made
a concentrated syrup (100 mg/cc) and this should be available
for clinical trial in the early fall.

that amitriptyline may have antiparkinaon
qualities intrigues me and I will look into this further.
Your comment

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
rd

"—7",

wvrvr-n

u-a

.

erI-wmv

.sz-wnku,

MP:kp

�</text>
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                    <text>&lt;
v

.,.

v

pruwuamr-n-r

v

,u
a

.m,,..-,-,

any"...

“g.

15,-3.1“...

{-

Juno 26. 1968

numwra

""‘K'K'ma

Dr. William Tabor

A. H. Rabin!
v

.1

(ww-

va-myv-z-mpm-p

an.

.

&amp;

Company

1407 Cunning: Drive
Richmond 20. Virginia

near Bill.

us-wr

«w-

&lt;v

c-

awtm’ﬂ‘c

W7~V~&gt;~o

0
4m;

.I'I'V’ﬁ'ﬂwwynw

In a recent letter you inquired as to our
procedure in adding some tasteful subatance to the
placebo of butaperazina elixir. Adopting a simple
procedure from our community, we have added to the
vehicle a small amount of Angoatura Bitters. This
has added a taste to the medication and, while
distinguishable from butaperaaine on direct trials.
has been of some use in our work.
have summarized each of the cases in the
present population and are now transcribing some of
We

the information to the Robina worksheets. We are
also preparing a written summary of our observations.
As soon as these are available. they will he coat to
you.

My

halt regards.
sincerely yours.
Max

Pink. Md).

Professor of Plyohiatry

Hszp

�</text>
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                    <text>Jun. 26.

1968

Dr. C. J. mt.’
Chairman. Departnnnc of Biological nhcnirtry
Univarsity of Athens
Laboratory Goudi
Athens 609, Graces
Dear Dr. Kirnn:
EEG studio: with
I haw. rtvicved ch. queation at aollgborntivo
marijuana with eh. Chairuan of thit Dupnrrnant and with '0'. ofRhch:
project officnrn a: tha Hational Institute of Minttl ﬂatlth.
that
are incoraﬁtsd in pursuing thin furthcr. for it auras unlikely
Evun
for
study;
tatruhydrocannabinol
at
as may rocaivn a cupply
and 1 fun: that ch.
if U! do. the appply will be twill, hawuvcr.
addirinnal
trials. A1c¢,
rcyults will b. indotcrninant, rcqnirin;
o!
an
chaurau
measurauenc
by
bu
complumanted
would
our itadies
the
described
populatian
in
such
you
as
chronic drug Iduinixtration.

in Athens.

invitation to visit with yuu
I wanid lit. to recap: your kind
1
would
hopa that this rould be
und
tho ant: til. I in in Europe
and
0!
ch.
don. bafora the
yrar.
and 11 a
staples that you thawnd II ware inconplgta
chant.
not. couploto so: could ha proviécd, I would lit: to review
tiara
ch.
(ar
tin.
ltitin
ago,
cnpocially i! a clinical dcseriprion
be
could
written
use)
of
unrijuann
dos: o! ﬁnrijunnt. durgtion
The

EEG

on arch aanplo.

Since I hsve no knowiud3u of tha populations available in
Athens. 1 canno: pieturc a reaucnublo projoc: and woula ask thc
answer to thc {allowing questions:
Uhur populations

in nn-bara of subject.

at abronic narijunna addicts 1t nvail¢b1c,
and

durntioa of radiation?

native marijuana users bu hospirnliaed and withdrawn
rnpidly in Athcns to that thc changes on withdrawal could be nonsuradf
Could

flﬂmp

.,
r...

A

-

y
«:w-

':'—‘v"~mvwmm-g-rsv

�:9:-

Dr. Hires

~2-

June 26, 1968

If an experiment

were planned for next winter, could acute
be
undertaken
a population of non—chronic users of marijuana
in
trials
Could
at your institution?
you supply tetrahydrocannabinol in sufficient
quantity to undertake a reasonable number (30-40) trials?
What

project outline

have you already discussed with NINE.

especially with regard to the
marijuana use?

EEG

In what specific ways could

aspects of chronic or acute

we

be of

assistance?

Finally, through what grantee agency have you received )ublic
Health Service Grants recently?

I look forward to hearing from you. I am taking the liberty
of sending a COpy of this letter to Dr. Henry Brill, whose assistance
will be invaluable if we are to undertake such a program.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

cc:

A. M. Freedman
H.

Brill

�</text>
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                    <text>Jdne 25. 1968
Dr. L. G. Beinensnn

Max

Planck

Institute

Bunsenstrssse 10
34 Gottingen. Germany

Deer Dr. Heinesenn:

I must apologize for this tardy reply to your
interesting letter and your reprints. Since our
report in Madrid. we have written s number of others
describing our 836 programs and I an enclosing reprints
of these as they have recently been published.
The examples given are quite simple and do not
do justice to the power of the analysis system. As
you indicate. there is e need for groeter communication
among the few workers interested in this type of analysis.
The programs which we use. those of period. power spectral

density. and amplitude analyses are available now for the
IBM 1800. This program is readily adaptable for the Inn
360 and should be easily usesble in the Control nets
series of instruments. If you have a programmer who is
interested in obtaining e copy of the print-out. we will

supply one.

In this country, the best work of the kind that
to interest you is undertaken by Drs. Mirsky end
cornetzky. both at the Division of Psychiatry. Boston
University School of Medicine. Boston. usssechusetts.
seems

�Dr. Beinsssnn

~2-

June 25, 1968

While there is some decresse otItrevel
Europe and the United States. I an sure that
of my laboratory will be in Eurupe this yes:
In the event we have an opportunity to visit

between
some

usibers

again.

West Germany.

may be useful to arrange a discussion in Gottingen
it
slninize the communication difficulties 01 letters.

work.

My

best regards and congratulations on your fine
Sincerely yours.
Mex

Fink. n.n.

Professor of Psydhiatry

HFskp

to

�</text>
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                    <text>June 25. 1968
Mr. Thomas M. Colasuonno,

Alcohol and Drug Section
Mental Health Division

Suite 300. Tenth
10 N. W.

Director

Avenue Building

10th Avenue

Portland. Oregon 97209
Dear Mr. Colasuonno:

Last week we received a phone call from
the Public Relations Section of the Division
requesting the cirriculun vitae and photographs.
These were sent and I trust that these are

satisfactory.

the

be
it
announcement
would

Drug Problems?

possible to send

me

a copy of

of the Western Institute

on

Sincerely yours.
Pink. ”.0.
m
Professor of Psychiatry

Mszp

�</text>
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v»

'Wmmm‘w’t‘Vn'

-_~.r-WV|I"‘~5IV

n
r

June 25, 1968
Dr. C. Giurgea

Head

of the Pharmacological

Research Department
68. Rue Berkendael
Bruselles 6. Belgium

Dear Dr. Giurgea:

I have read your reprints with a great deal of

interest, especially your chapter

on the sequential
drugs and your report at

screening of antidepressant
the CINP. Both seem to make the point quite well
that the present prlgmatic methods are satisfactory
in identifying compounds similar to established antidepressant agents. The real test will come in the
identification of useful psychoactive agents which
bear little resemblance to the compounds of today.
In a review of our studies of cyclazocine as an
antidepressant. I am taking the liberty of referring
to your work as an example of the variety of tests
used in the evaluation of new drugs today.
My thanks for your reprints and
for continued success.

my

best wishes

Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>r—_—._—WV,—_,——__—T_—sc—WWV,1W.V

.
,
i-._.&gt;'r‘~wl'{*3‘e,qrPII-F'VKISV5-

».

we“... “chm—MW” . _._
.

A."

“mm"-

.,,.._....

‘

_,-

w."

“.1

.

vagawmur

.

k

“Wuhan”.

June 25. 1968
Dr.

c. Giurgea

Head

of the Pharmacological
Research Department

68. Rue Berkendael
Brueelles 6. Belgium
Dear Dr. Giurgea:

I have read your reprints with a great deal of
interest. especially your chapter on the sequential
screening of antidepressant drug: and your report at
the CINP. Both seem to make the point quite well
that the present pragmatic methods are satisfactory
in identifying compounds similar to established antidepressant agents. The real test will come in the
identification of useful psychoactive agents which
bear little reseﬂblance to the compounds of today.
In a review of our studies of cyclazocine as an
antidepressant, I am taking the liberty of referring
to your work as an example of the variety of tests
used in the evaluation of new drugs today.
thanks for your reprints and
for continued success.
My

my

best wishes

Sincerely yours.
Max

Pink. “.0.

Professor of Psychiatry

Mrskp

“me. at,

r.

“N 7‘.

z./

_

-

~

.~--

�</text>
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                    <text>J. Turner
Biomedical Research Associates of the
Dreyfus Charitable Fund

Dr. William
177 Main

Street

Huntington. new Ybrk 11743
Dear

Bill.

I went to thank you for the reprints whioh
you sent. relating the effects of Dilentin on
seizures. The date appears quite sparse. and
except for the single report of Holt and BorkOWIki
in 1951. none approach the problone of convulsive
therapy.
I have recently instituted e study of convulsive
therapy at Gracie equate Hospital and when I stimulate
a few more young residents to work there. I think I

will

look

at this

Thank you

problem.

for your c00peretion.
Sincerely yours.
Mex

Fink. M.D.

Profeleor of Psychiatry

Wakp

�</text>
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                    <text>June 25. 1968
Dr. Jerome Levine

Psychopherueoology Research Branch

National Institute of Mental Health
5454 Wﬂeconein Avenue
Chevy Chase. Herylend

Deer

Jerry.

With your assistance. we have received an
Inn (4724) for the etudy of marijuana end marijuana

extracts.

Bncloeed is e copy of the FDA approval.
study progren has been accepted by the Ineeeroh
committee of the college and by the counieeioner of
Hoepitele of the city of New York. we also have e
tux stump from the Internal Revenue Service indicating
our interest in studios at marijuana.

Our

If this completes the ueuel administrative
etepe. we would be grateful for e supply of
tetrehydrocennebinol. Following the suggested
doeege of 20 mg per experiment. e supply of 600 no
would permit no to make a reasonable eetinate of
the neuroohyeiologicel profile.
Thank you very much

guidance.

for your cooperetion

end

Sincerely youre.

7—,.

~&lt;

Pink. N.D.
Profeeeor of Psychiatry

Hex

ﬂPﬂtp

�</text>
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                  <elementText elementTextId="102607">
                    <text>June 25, 1968
Mr. Stephen Root

Organization unit
New York City community Mental
Health Board
93 worth Street

New

York.

New York

Dear Mr. Root:

writing at the request of His: Fini
Zolae
is applying for a position with your
organization. I have know Miss Zolae for more
than a year and she has served an the coordinator
of the Mental Health Clinic at Motrogolitan Hospital.
Following the resignation of the clinic Director in
January 1961. I assumed responsibility for the clinic
Operation. Since I hedewa prior commitment in the
development in the research and training program: in
peyohoﬁharmacolOQYo I requested the aasiatance of an
administrative officer to coordinate the treatment
and teaching activities of the clinic. Misc Zola:
wan recommended by the executive officer of the
Department and I have been pleased with her service
since.
1 am

who

past year, the clinic has been
reorganized no that the dropmout rate has been
reduced significantly. the waiting time for patients
During the

has been minimized. and the record keeping of the
unit has been completely overhauled. At the time
that miss zolaa assumed responsibility. we had no
accurate count of the patients in treatment. the
records were very incomplete. and we were faced

with one crisis after another. Misc zolas accepted

�unma-

(“nary-

Hr. Root

:IVV':-r".";

~2~

Jena

2

25. 1968

"\“‘-W

w:

,

‘w—wvl-I'W‘ln‘w-

“yr

—
.
—-v
.

w“.

the responsibility of reorganizing the record keeping.
providing a better system for appointments and followup and in establishing improved relations with other
units within the Department. In each of these efforts.
she has succeeded and her work has made possible the
development of a very active research and treatment
program within the Mental Health clinic.
With further development of the community lental
health center. a combination of the Mental Health Clinic
and the walk-In Clinic has been entertained. In this
reorganization. I would relinquish the supervision of
the Mental Health clinic and Miss zolas has indicated
that the new structure does not provide the same
administrative opportunity that the present clinic does.

In her relations with the staff or the clinic. the
patients and with myself. I have always found her affable.
friendly. courteous. and diplomatic. She is well liked
by the staff and instills a feeling of confidence in the
patients. In her supervision of the social workers of the

clinic.

she has enhanced their growth and improved their
participation in the clinical care of patients as wall as
in our conferences. In one special. that of research.
she has taken an interest and provided enthusiastic
assistance so that our present programs have been enhanced.

I regret that she has decided to seek another
position. for her association in this unit has been
soot useful to no and the present improved efficiency
of the Mental Health clinic is largely the results of
her efforts.
Sincerely yours.
Pink. ”.0.
m
Professor of Psychiatry

”mp

�</text>
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  <item itemId="3402" public="1" featured="0">
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                  <elementText elementTextId="102608">
                    <text>June 21. 1968
Dr. Richard White
c/o Dr. Phillip Bradley
The Medical School
Birmingham 15. England
.

Dear Dick,

I must. once again. congratulate you on a
fine piece of work. It is a pleasure to be associated
with this effort. Once I started to add some additional
information and references. I took the liberty of making
some small changes in the text and have had it complotely
retyped.
The original has been sent to Joe wortia.

If

Three copies are enclosed, as well as your original.
thorn are any additional corrections I an sure you can

make them

in the galley.

I look forward to hearing from you from England
and trust that your work there will be as rewarding as

you

anticipate.

I have also taken the liberty of sanding capias

to Drs. bird. Sigg. Martin. Brill and Levine each of
whom has sithsr been cited in the credits or has been
instruncntal in providing the funds for this study.
—

Hy

best regards.
Sincerely yours.
uax Pink. M.D.

Professor of Psychiatry

�</text>
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                    <text>Jdne 25. 1968
Dr. L. G. Heinenann
ﬂax Planck Institute

Bunsenstresee 10

34

Gottingen. Germany

Dear Dr. Heinemann:

I must apologize for this tardy reply to your
interesting letter and your reprints. Since our
report in Hadrid, we have written a number of others
describing our EEG programs and I am enclosing reprints
of these as they have recently been published.
The examples given are quite simple and do not
do justice to the power of the analysis system. As
you indicate. there is a need for greater communication

among

the

few

workers interested in this type of analysis.

those of period, power spectral
density. and amplitude analyses are available now for the
IBM 1800. This program is readily adaptable for the IBM
360 and should be easily useable in the control Data
series of instruments. If you have a programmer who is
interested in obtaining a cepy of the print-out, we will

The programs which we use,

supply one.

In this country, the best work of the kind that
to interest you is undertaken by Drs. Mirsky and
Cornetzky. both at the Division of Psychiatry, Boston
University School of Medicine, Boston. Hassechusetts.
seems

�-2-

Dr. Heineaann

June 25. 1968

While there is some decrease of travel between
Europe and the United States. I am sure that some members
of my laboratory will be in Europe this year again.
In the event we have an opportunity to visit West Germany.
it may be useful to arrange a discussion in Gottingen to
minimize the communication difficulties of letters.
work .

My

best regards

and

congratulations on your fine
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mszp

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                    <text>June 25. 1968
Miss Helen

M. Reed

Northport.

New York

Ediciones Profesionalea. S.A.
l9 Baton'a Neck Road

Dear Mien Reed:

Enclosed are two reports of ourlatudies
of narcotic antagonists in the treatment of
Opiate dependence. as well as a summary of the
treatment model. Most of the interest has been
in the use of cyclazocine. This agent is available
in the United States for research and more than

patients have been treated. Recently. naloxone
was studied and the supply has been severely
limited so that we have been able to study its
effects in seven patients only. The results
were sufficiently exciting. however, to cause
us to ask that additional supplies be provided
by the manufacturer and these are now in production
and should be available for testing before the end
150

of the year.

the heat of

To

my

knowledge.

neither

compound

is available for clinical or research purposes outside
the United States. so that your report must restrict

itself to

a statement of the research merit only.

At

the present time. the only widely used compound in the
treatment of opiate dependence generally available is

methadone.
A

photograph is enclosed and I would be pleased

to receive copies of

E1 Medico when

thin report appears.

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

�</text>
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                    <text>June 25, 1968
Mr. Stephen Root

Organization Unit

city Community Mental
Health Board
Worth Street

New York
93
New

York,

Dear Mr.

New York

Root-2

writing at the request of Miss Fini
Zolas who is applying for a position with your
organization. I have know Miss Zolas for more
I

am

than a year and she has served as the coordinator
of the Mental Health Clinic at MetrOpolitan Hospital.
Following the resignation of the clinic Director in
January 1967. I assumed responsibility for the clinic
Operation. Since I bade a prior commitment in the
develoyment in the research and training programs in
psychopharmecology. I requested the assistance of an
administrative officer to coordinate the treatment
and teaching activities of the clinic. Miss Zolas
was recommended by the executive'officer of the
Department and I have been pleased with her service

since.

During the past year, the clinic has been
reorganized so that the drOp-out rate has been

reduced significantly. the waiting time for patients
has been minimized. and the record keeping of the
unit has been completely overhaﬁled. At the time
that Miss Zolas assumed responsibility. we had no
accurate count of the patients in treatment, the
records were very incomplete. and we were faced
with one crisis after another. Miss zolaa accepted

�-"

WW

:--u|-)-7—~&lt;1r.rrvw7'wo'5“‘“'-‘-'g'":‘ﬂ

Mr. Root

~2-

June 3 25. 1968

the responsibility of reorganizing the record keeping.
providing a better system for appointments and follow—
up and in establishing inproved relations with other
units within the Department. In each of these efforts.
she has succeeded and her work has made possible the
development of a very active research and treatment
program within the Mental Health clinic.

further devalOpment of the community lental
health center. a combination of the Mental Health Clinic
and the walk-In Clinic has been entertained. In this
reorganization, I would relinquish the supervision of
the Mental Health Clinic and Miss zolas has indicated
that the new structure does not provide the same
administrative Opportunity that the present clinic does.
With

In her relations with the staff of the Clinic. the
patients and with myself, I have always found her affable.
friendly. courteous, and diplomatic. She is well liked
by the staff and instills a feeling of confidence in the
patients. In her supervision of the social workers of the

clinic, she has enhanced their growth and improved their
participation in the clinical care of patients as well as
in our conferences. In one special, that of research,
she has taken an interest and provided enthusiastic

assistance so that our present programs have been enhanced.
I regret that she has decided to seek another
position. for her association in this unit has been
most useful to me and the present improved efficiency
of the Mental Health Clinic is largely the results of
her efforts.
Sincerely yours.
)1":

"-

“ax Fink. “one

Professor of Psychiatry

wu—Iug’wzr-xw“

.v

a

Mszp

�</text>
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                    <text>June 25. 1968
Dr. William J. Turner
Biomedical Research Associates of the

Dreyfus Charitable Fund

177 Main

Street

Huntington. new York 11743
Dear

Bill,

I want to thank you for the reprints which
sent, relating the effects of Dilantin on
seizures. The data appear: quite sparce, and
except for the single report of Holt and Borkowoki

you

in 1951. none approach the problems of convulsive
therapy.

I have recently instituted a study of convulsive
therapy at Gracie equare Hospital and when I stimulate
a few more young residents to work there, I think I

will

look

at this

Thank you

problem.

for your c00peration.
Sincerely yours.
Max

Fink, M.D.

Profs-nor of Psychiatry

Mfzkp

�</text>
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                    <text>June 6, 1968
Mr. Earl Ubell

CBS News

5l West 52nd Street
York. New York

New

Earl,

Dear

If you want to know
limited in this country.

why research in marijuana is
I would suggest you read the
enclosed documents which I have Just received from the

far exceeds any requirement of the
Administration with which I have had to
comply for any drug since 1952, including hallucinogens
and heroin.
This procedure

NIMH.

Food and Drug

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszp
enc.

�</text>
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                    <text>June 6, 1968

Ziering, R.N.
Psychiatric Instructor

Miss Hannah

The Englewood

Englewood,

New

Hospital Association
Jersey 0763l

Dear Miss Ziering:
would be pleased to have you and your students visit us
and because Thursday is the best day for part of the demonstration,
I suggest you come on June 27 and August 8.
We

The core demonstration would be a case conference held on
Thursday from 10:30 am to 12:00 noon on ward 12. If you can
arrive at 9:30 am, I will arrange for a tour prior to the
conference. From 12:00 to 1:00 we will arrange for one of the
nurses who would explain the nursing aspects of patient's care

in these units.

If you tell us the number of persons coming, I will ask to
arrange for you to have lunch and after this you will meet with
one of our physicians and a member of the rehabilitation team.
A good overview can be obtained by 3 o‘clock.
If time is short,
then we would suggest that you not attend the conference and we
can arrange for discussions from 9:30 to l2:00.
I

will arrange for our psychiatric assistants to be with
will provide a continuing commentary.

you throughout the day and they

it

As I discussed with you on the phone,
would be most helpful
I could provide the psychiatric assistants with an honorarium
for their time and I would suggest that the Englewood Hospital

if

Association sencitwo checks in the amount of $50.00 each in the
name of Manuel Rodriguez and Albert Hassan. Please send the checks

to

my

office.

Please confirm

if

the dates and times are satisfactory.
Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max

Mszp

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                    <text>June 6, 1968
Dr. E. R. Gabrieli

Director, Clinical Information Center
University of Buffalo
Buffalo, New York
Dear Dr.

Gabrieli:

letter in the

this medical school,
of the activity is in the Department of Psychiatry and we
are involved in developing a coordinated data processing system
I saw your

much

for psychiatric data.
toyyour meeting.

for

We

would

Would you

any announcements?

J.A.M.A.

In

like to send

please put us

a representative
on your mailing

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

list

�</text>
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                    <text>June 21. 1968
Dr. Joseph G. Bird

Sterling-WinthroP Research Institute
Rensseleer, New York 12144
Dear Joe,

Enclosed is a draft of a pharmacological study
of cyclazocine undertaken at the university of Tennessee.
at our request. This was presented at the Society of

Biological Psychiatry on June
in their annual proceedings.

15 and

will

be published

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

Hfzkp

enclosure

�</text>
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                    <text>Jana 21. 1968
Dr. William Martin

National Institutes of Rental analth
5454 Wisconsin Avenue
Chevy Chase. Maryland

Dear Dr. Martin:

Enclosed is the next chapter in our continuing
interest in cyclazocina. Dick White was kind enough
to run those studies just before he left for Birmingham.

Apparently, cyclazocine compares favorably with iniprauino

in his model.

Sincerely yours.
Max

Fink. M.D.

Protester of Paydhiatry

MPH“)

�</text>
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                    <text>June 21. 1968
Dr. E. B. 5199
Geigy Pharmaceuticals

Ardeley.

New York

Dear Dr. 3199:

Enclosed is a report recently presented at

the Society of Biological Psychiatry. Dr. White
has requested that we send you a cepy as he has
just left for England. He wishes to thank you for
your cooPeration.
Sincerely yourl.
Mex

Profeseor of Psychiatry

,
R,

Jr.

U,
,5

Mszp

,

'tV.“w-I

a,
.A

u

r
|

”s
A»

nr

my.qz,vym-v1;,q

HQ:

ﬁr“):

mqvm-w-

mr—mmwm

(ATFWWTVH'I‘WLVWH

wruﬁgh‘w-

up

Fink. H.D.

enclosure

�</text>
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                    <text>June 21. 1968
Dr. Jerome Levine

Peychophernecology Research Branch
National Institutes of Mental Health
5454 Wieconein
Chevy Chase, Maryland

Deer

Jerry.

is

draft

copy of a pharmacological
undertaken
by Dr. Richard White
study of cyclezocine
and
supported by
of the university of Tennessee

Enclosed

a

Dr. White found thet cyclezocine we:
indeed like imipreminc in its pharmacological profile
and I em planned that the reunite parallel our clinical

HH~12567.

experiences.

Many Ebenke

for the support of van in this study.
Sincerely yours,
Hex

Fink. n.D.

-

Protease: of Psychiatry

MFskp

enclosure

�</text>
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                    <text>Juno 21. 1968
Dr. Henry

Brill

Narcotic Control Commission
1855 Broadway

Haw

York.

New York

Dear Henry.

Enclosed is another chapter in the saga of
cyclazocine. This study was done in Tanneasee
with can» assistance from us. I think it will

interact

.

you.

I want to thank you once again for sanding
Miran
Dr.
was a most interesting
to no. for
visit and 1 hop. that something can bu workcd
out in colldboration with him.

it

My

best rogards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Wtkp

�</text>
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                    <text>June 20. 1968
Dr. Joseph

wertis. Chairman

Editor of 1967 Transactions
152 Hicks

Brooklyn,

Street
New

York

Dear Joe.

Enclosed is a draft copy of our article from
the meeting on Saturday in washington.
Dr. White

will

be spending the next year in

the laboratory of Dr. Phillip Bradley in Birmingham.
the galleye are available it would be useful if
you would send me a set for you may get them quicker.

When

My

best regards.
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>Jane 19. 1968
Dr. Roland R. nonato and
Dr. William Guy
George Washington university
Room

1145

Bionstrio Laboratory

618

Nineteenth Street. H.w.

washington. 0.6. 20036
Dssr Ron and Bill.

I want to thank you for the data outputs and
tho
for
tins you spent with no on Friday. I discussed

tha outputs with my associates and we are pleased with
the nothods of presentation. I pointed out that we
were missing the drug-dose data and these forms ars
bsing completed now.
Enclosed ars two cepies of the laboratory report

which describes the standards

in plscsbo traatod patients

during my stay in Missouri. I think this is an important
nodal for all drug studies.

I look forward to seeing you

Monday.

Sincerely yours,
Max

Fink. M.D.

Professor of Psyohiatry

nfzkp

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                    <text>June 19. 1968

Professor

Hex Hamilton

Department of Psychiatry
The University of Leeds

ls

Hyde

Terrace

Leeds 2. England

96‘!

Max.

I have received a telephone call from Nathan
for

if

I had room in my laboratory
Hamilton's by the name of John
a disciple of
Nicholas Hall. Of course. I said yes. When I
is
called George Simpson he told me that ur. Hallcoming
in
who
is interested
a clinical psychologist

Kline asking an

Max

for three months.

I have missed talking to you over the past few
years. but I have not remained idle. This laboratory
has an in-patient and outvpatient component focussed
at
on narcotic addicts and psychotic-z a study in ECTEEG
for
a large private hospital: a computer facility
analysis and other data processing: and assorted
psychologists. residents. 25g.
If ur. Hall is interested in working in the kind

of a show that I had at Hillside. but immeasurably better.
is one problem
I would be pleased to consider him. Thereand
with
if not from
which I would like to have some help
have
we
him. perhaps from one of your other sorters.
been using the Hamilton Rating Scale and have written a
kinds of depression
seall program to classify differentitems
of historical
seven
adding
from that scale after
of
depressives.
information. I have a large population
(we
fun 50
both before and during convulsive therapy
treatments a day). at this point I would be interested

�d

Professor Hamilton

—2—

June 19. 1968

in having codibody work with my residents in the
proper application of the scale and in exploring
its diagnostic and even some of its predictive
features. surely. I would not restrict the work
to this scale elone. but would be pleated to use
some other measures.

tell: no that Mr. Hall would like to
in
curly
July for three months. I think three
months is somewhat short. especially over the summer.
but I would be glad to entertain him for that period
if you think it would he mutuelly useful.
The next time you wish to send someone. perhaps
you would think of no.
my best personal regards.
come

George

Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

MF:KP

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                    <text>June 17, 1968
Dr. William Triebel
Gracie Square Hospital
420 East 76th Street
New

York,

Dear Dr.

New

York

Triebel:

I would be pleased if you would consider the appointment
of the following members of the staff of the Department of
Psychiatry of the New York Medical College to the staff of
Gracie Square Hospital.

Research Psychiatrist
Research Psychiatrist
Research Psychiatrist

Richard Abrams, M.D.
Robert Levine, M.D.

Michael Taylor, M.D.
Alfred Bruner, Ph.D.

Electroencephalographer
Psychologist

Rhea Dornbush, Ph.D.

Patricia Landis
June Horwitz

Research Nurse
Research Nurse
Research Assistant
EEG Technician
EEG Technician
EEG Technician

Phyllis Karliner

Suzanne Kraft
Pauline DaCosta

Constance Martane
Kathleen Pelczynski

Secretary

While I do not expect each of these people to be at Gracie
Square at the same time. they are all participating and should

feel that they are included in the Gracie Square Family.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>June 17. 1968
Dr. martin Halliday

National Hospital

Queens Square

London. England
Dear Dr. Hellidey:

recently visited your
laboratories. was diacuaeing your program of research
in convulsive therapy and indicated that you had made
some novel observations on differences in memory
Dr. Charles Shagaee. who

function with the unilateral and bilateral treatments.
are studying this prdblem and your experiences may

we

helpful. for Dr. Shagaee indicate: that different
memory tasks yielded differences in results for seizures
on the dominant and non~doninant sides.

he moat

If these reports are

indeed correct. I would be

grateful for e preprint of your report: or
published. the citation or reprint.

most

Thank you

very

much and my

it

congratulationn on

having made such a forceful impraeeion on

friend.

my good

Sincerely yours.
Max

Fink. u.D.

Professor of Paychiatry

Hakp

�</text>
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                    <text>June 17. 1968
Executive Secretary
Marihuana Advisory committee
Center for Studies of Narcotic and
Drug Abuse

National Institute of Mental Health
USPHS~BHEW

5454 Wisconsin Avenue
Chevy Chase. Maryland 20203

Dear

Sir:

Enclosed are twenty~£ive copies of the documents
which you have requested in order to provide us with
supplies of marihuana and tetrahydrocannabinol for

investigational purposes.
1a)

b)
c)
d)

See protocol attached
See curriculum vitae
See protocol
Baa

~
~

Exhibit
Exhibit

1
2

protocol

For marihuana trial: we will require approximately
one ounce for every ten experiments and would like to request
four ounces an an initial aupply.
2)

is

For tetrahydrocannabinol we understand that 20

an average dose and
3)

for

20

trials

we would

roquiro

Both marihuana and tetrahydrocannabinol

stored in an approved narcotic safe at
Eighth Floor.

Room 42A.

recommendations.

Documentation

is

4)

Curriculum vitae

5)

Institutional setting:
a)

5

East

will be
Street,

102nd

will follow your

oncloaad.

Department of Paychia try. new York medical
College and Hetropolitan Hospital Medical

Center.

mg

400 mg.

�b)

This project has been approved by the
Chairman of the Depertoent of Psychiatry.
the Research Committee of the New York
Medical College-Metropolitan Hospital
Medical Center and the Commissioner of
Hospitals of the city of new York.
See letter. marked Exhibit 3. 4 and 5.

6o)

b)
3;

IHD 4724

-

EXhibit 6

See Exhibit 5 - Letter from Rosearch Committee.
Consent form ettedhed ~ Exhibit 7.
Merihuene Tax Stomp ~ Exhibit 8.

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

Wakp

enclosures

�</text>
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                  <elementText elementTextId="102627">
                    <text>June 17. 1967
Dr.

Fletcher

Owens

A. H. Robins Conpany
1407 Cummings Drive
Richmond 20, Virginia

Dear Dr. Owens:

I

am

writing to bring to your attention a

small problem with capsules of Tybatran. During
the last two weeks. When the weather has been
unusually hot. the capsules have developed a
gelatinous softening and the surface has changed
from being smooth to one that is grossly irregular.
On occasion the capsules have stuck togethsr.
This occurred in our clinic, but also to
two of our patients who insisted that the capsules
had been kept in their pockets.
The nurses have brought this to my attention
with a question as to whether tho capsules ought
to be kept refrigerated.
My

best regards.
Sincerely yours.
Max

Fink. NJ).

Professor of Psychiatry

Wdtp

�</text>
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                  <elementText elementTextId="102628">
                    <text>June 17. 1968
Dr. Stanley P. Yolles

Executive Director

National Institutes of Health
5454 Wisconsin
Chevy Chase. Maryland

Dear Dr. Yolles:

I want to

talks. both in

tell

New

you how much I enjoyed the

York and Washington.

I discussed with you. I am enclosing a
copy of the present marijuana procurement procedures
as sent to me by Dr. John A. Scigliano. While we
will attempt to comply with these requirements. I
think it would be useful to make the procedures
lees onerous. Surely. marijuana and THC cannot
be so dengerous that the procedures should be
significantly different than the testing of
investigational drugs.
As

assistance you can give to make marijuana
institution
or THC available for stucy at this(EEG
MH-13358
and Human
under our present grant
Any

Psychopharmacology)

will

be appreciated.

Sincerely yours.
Max

Fink.

14.1).

Professor of Psychiatry

Hakp

�</text>
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                    <text>June 17, 1968
Dr. Martin Hallidsy

National Hospital

Queens Square
London, England

Dear Dr. Halliday:

'

Dr. Charles Shagass, who

laboratories.

recently visited your

discussing your program of research
in convulsive therapy and indicated that you had made
some novel observations on differences in memory
function with the unilateral and bilateral treatments.
We are studying this problem and
your experiences may
be most helpful. for Dr. Shagass indicates that different
memory tasks yielded differences in results for seizures
on the dominant and non-dominant sides.
was

If these reports are indeed correct. I would be
grateful for a preprint of your report; or if
published. the citation or reprint.

most

Thank you very much and my

congratulations on

having made such a forceful impression on

friend.

my

good

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

��</text>
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                    <text>June l3, l968

Librarian

York Academy of Medicine
East l03rd Street

New

2

New

York,

New

York

Dear Madam:
I would be grateful if you would permit Dr. Robert Levine
to work in the library during the hours open to Fellows as he

is working

on a

If he finds
his doing so.

project for

it

me.

necessary to take books out,

I would approve

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 6, l968
Dr. Burtrum C. Schiele
Professor of Psychiatry
Department of Psychiatry and Neurology
University of Minnesota Medical School

Minneapolis, Minnesota 55455
Dear Burt,

I have Just spoken to Joe Bird and since no meeting of
the investigators of cyclazocine is being planned for June,
I am suggesting that perhaps we can get togehter during the
ECDEU meetings on June 24-25.
In the meantime I am enclosing
the prepublication copies of the two reports from this and
Dr. Itil's laboratory which will be completed in the next few
weeks and sent to a psychiatric Journal.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>June 13, 1968
Dr. Thomas Williams

National Institutes of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Dr. Williams:

Enclosed is a copy of the HEW Indirect Cost Statement,
dated June 4, for the International Association for Psychiatric
Research, Inc.
Thank you

for your cooperation.
Sincerely yours,
Max

Mszp

Fink,

M.D.

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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