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                    <text>January 26, 1968
Dr. 3. Clyde

Merck Sharp

West

&amp;

Strickland
Dohme

Point, Pennsylvania

19486

Dear Clyde.

In Monday's mail we received an additional 2400 tablets
of Cogentin. There was no packing slip nor any date on the
outside wrapper. so I cannot tell which of the two supplies
came

first.

Many

thanks and we

now

have more than adequate

supplies.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

l

�</text>
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                    <text>January 26. 1968
Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School

5.”.

3181

Sam

Jackson Park Road

Portland, Oregon

97201

Dear Paul.

project at Gracie Square

has begun and like all such projects
have obtained the concurrence of the staff and
appointed both a nurse and physician to the staff. I am recommending the
appointment of a psychologist whom I have Just met. The EEG equipment was
delivered this week and the laboratory will be set up early in February.
We have written some computer
programs for diagnosis using the Hamilt‘n
The

is progressing slowly.

Rating Scale.

We

expect to
bilateral treatment in
MMECT in the early summer.
and

'
.
*’

‘*2

I

make some
March and

A few days ago I received a phone call from Dr. Strain who heard
of my interest in ECT. He reminded me that he is coparticipant in our APA
panel, and while I have done little for that presentation, I look forward
to it.

I read your

notes

on

and the observations are very

'
M"

-'
’

-,.
-

12:11:.s,»‘~'=«;~

.«pr

1.0.2:»

"w

-

systematic observations in unilateral
and should be ready to start

April,

Pyridoxine.

interesting

this
further study.

I know nothing about

and warrant

compound

Enclosed is a preliminary report of our experiences with naloxone,
as well as a reprint of our cyclazocine data. Of the two drugs, used in
the same population, the naloxone gave us less complications, was better
accepted and seemed more promising as a therapeutic agent than cyclazocine.
I regretqi very much that we were unable to continue our study because the
manufacturer discontinued production because of expense. I am trying tn
every reasonable political way to urge continued production of the compound
for I think it holds much promise.

-.?r.".«':‘rW€;.-N+f.~.m.

Fem

ﬂat—ﬁle.

for

Incidentally, your

comments on acetylmethadol

are most interesting,

have never heard of this material. A year ago we asked Sterling Winthrop
(and were supported in our request by NIMH) to produce a long acting cyclazocine.
This has not yet been done.
I

My

WWW

"ﬂ

best regards.
Sincerely yours.

HT’VK-Willi-

'1713i75m7W-u72'v'ﬁ”

Fink, M.D.
Professor of Psychiatry

Max
W

FV‘T'

if"
—

5
~

MF:kp

�</text>
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                    <text>January 25, l968
Dr. Daniel Silverman
269 South l9th Street

Philadelphia 3, Pennsylvania
Dear Dan,

in no position to advise you on how to act with
delinquents. Perhaps reconstructing the remarks of recalcitrant
discussants or omitting their remarks all together are the
I am

principal solutions.

delighted if the; were to appear as a supplement
Journal. I have no objections to editorial assistance

I would be

to the

EEG

from Hoffman-LaRoche.
Good luck!

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

a

‘

WWII.”

�</text>
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                    <text>v7”.

January 25. l968
Dr. Perry Black
Division of Neurological Surgery

Johns Hopkins HoSpital
60l North Broadway
Baltimore, Maryland 2l205
Dear Dr. Black:

Enclosed are two copies of the report "Orugs, EEG and
and the
Behavior." as a contribution to the symposium "Drugs
Bra n.‘

mammm

.wn‘

w"

1:
u,

is.

For publication purposes the prooer academic affiliation
Professor of Psychiatry. New York Medical College.

31-me-

Thank you

Wm

r

for your kind invitation.

"'

1;:-

Sincerely yours,

.
~,\,/€?:Il,

1»;ngst

Fink. M.D.
Professor of Psychiatry

Max

wan-man:

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                    <text>January 24. l968
Dr. 8. A. Lebedev

medical Officer

Mental Health Unit
World Health Organization
Avenue Appia
Geneva « Switzerland

lle

Dear Dr. Lebadev:

It was

good to hear

that

you are

still

considering a

meeting of investigators interested in international studies
with psychotropic drugs. Our study programs with the

University of Istanbul are progressing well, and it is on
route to that Center that I plan to stop in Switzerland.

I am confident that Dr. Itil would be pleased to represent
this program. He is PrOQEssor of Psychiatry at the University
of Missouri School of Medicine and holds a concurrent appointment
at the University of Istanbul. His address is:
Dr. Turen

M.

Itil

Professor of Psychiatry
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri

My

63139

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>~

.A.«

.i

v

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‘
-

M‘V-ﬁ/rwp'wn—W‘W'Wmm-‘vu-I—vr

January 24, l968
Dr. Turan H.

.

.uwvzns

.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Turan.
I have

received a

letter

from Dr. B. Lebedev of the World

Health Organization inquiring about our Turkish collaborative
study. A copy of his letter is enclosed as well as my reply.

1’!

wow

4.7K.

‘Vl'i.§&lt;

Would it be possible for you to visit with us on Friday,
February 2, to discuss a presentation before the Separtment
staff? Drs. Bucci and Simeon are presenting our observations
with depot fluphenazine and we would be pleased to have you
discuss this presentation. The meeting is held at l2:l5 pm
in the sixth floor auditorium at Metropolitan Hospital (97th

Street

var:

My

and

First

Avenue).

best regards.
Sincerely yours,
Fink, N.D.
Professor of Psychiatry

Max

MF:kp

_
A

.»

:ﬂwwm‘ﬁwtﬁ'ﬁlhr'y-s-

new-v»

a1"

‘1'

�</text>
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                    <text>January 23, 1968
Dr. Gerald L. Klerman, Director
Connecticut Mental Health Center
P. 0. Box 1842
New Haven, Connecticut 06508
The

Dear Gerry,

It was kind of you to accept my invitation to participate
in the resident training seminars in psychopharmacology of the
New York Medical College.
have requested a special meeting of the class on Tuesday,
at 4:00 p.m. The meetings are held at Metropolitan
97th
Street and First Avenue.in the fifteenth floor
Hospital.
I

March 19,

classroom.

it

would
you can see from the enclosed list of seminars,
would
in
discuss
social factors
the evaluation
helpfulif you
of treatment and in the effects of psychotropic drugs.
As

be

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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Dr. John L. Voigt. Director

Pharmaceutical Extension
Rutgers - The State University
l Lincoln Avenue

Newark,

New

Jersey O7l04

Dear Dr. Voigt:
be

Thank you very much for your invitation. While I would
interested, I will be out of the country on March 2.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>«~3-

armarn

‘r‘r‘

”WW-u-

man-r

"qr-(mum

:w

W

-,.w

"Irw-o-m—wmmmmv

r

January l9, l968
Dr. Jerome Levine
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Uisconsin
Chevy Chase, Maryland
Dear

Jerry,

Enclosed are two cepies of the report "Naloxone
(N-Allylnoroxymorphone) in Opiate Dependence."
my coworkers and l are saddened by our
additional supplies of this compound.
obtain
to
inability
To us, further studies are important as the therapeutic
potential of this compound appears extremely high. we
would appreciate any efforts that you can make to obtain
the cooperation of Endo Laboratories in further production
of this compound.

As

you know,

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>.

.

Jammy 18,

"mam-w

V:',vc"nmu'.

4""

1968

Miss Karen Slotky
Copy Editing Department

Meal

American
Associatim
535 North Dearborn Street
Chicago, Illinois 60610
WWW»7«W‘&lt;1'z‘waywavxe-ww

A

Dear Miss Slotky:

I am writing with regard to the report "Long—Acting Depot
Phenothiazim Treement of Psychosis." My associates in St. Louis
have reviewed the paper and I an enclosing pages which they feel
warrant correction.

_
«ray-W

'W

'

The page nunbers referred to are your page numbers, marked in
the upper right hand corner. On page It, the last line of paragraph
lshouldmsd’WtoQSmeks." InpamgraphZ, tmelinesfmthe
bottan delete "(Table 2)." The last sentence should
be changed by
deleting "disoonfort and secondary" and replacing by "eutrspyrmnidal."

'I‘i-‘AWUW'TW

64"

l'.

On

page 5, the paragraphs require a few changes and these are
the attached page 5.

marked on

principal changes are in the results and I have taken the
liberty of retyping pages 6 and 7. Following your editing, please
use these to substitute for all of 6 and most of page 7 up to the
portion marked secondary effects.
On page 8 , we Nomad suggest that paragraphs be deleted foam
the section starting "10 patients in group Eb" and "9 patients in
The

group 2" .

Similarly, the section on page 9 "there was no weight loss"
is logically a continuation of the previous paragraph.
_

In the smmsry, in paragraph 2, the third line should be
charged to read "discmrgeable, and seven did not improve. The”

(the

word secondary should be

deleted).

�-2-

Miss Slotky

January 18, 1968

Finally, the tables have became inverted and table 3 should
2 and table 2 shwld be marked table 3. m1: is,
2
in Individual Symptoms with Fluphenazine
"Changes
table is
Decanoate" and table 3 is "Mode and Outoane of Treatment."

be mrked table

Thank you

for your cooperation.
Sincerely yours ,
Max

Firm, M.D.

Professor of Psychiatry

MF:kp

�</text>
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Dr. S. Clyde Strickland
Merck Sharp &amp; Dohme
West Point, Pennsylvania l9486
Dear Clyde.
have received the supply of 2400, 2 mg tablets of
Cogentin. I want to thank you and to tell you that I regret
the difficulties. we have not been able to trace the first
We

package.

Thank you very much

for your couperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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Dr. Richard Ellingson
Nebraska Psychiatric Institute
602 S. 44

Avenue

Omaha, Nebraska 68105

Dear Dr. Ellingson:

It

was a

My

best regards.

pleasure to participate in the Sugerman project
I am taking the liberty of enclosing copies
of reports recently prepared which summarize our present View
of the relation of EEG, psychotropic drugs and behavior. These
reports were prepared for the recent ACNP meetings, and are to
be considered drafts requiring additional editing.
review on Friday.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>January 16. l968
Dr. Burtrum C. Schiele

Professor of Psychiatry
Department of Psychiatry and Neurology
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dear Burt,

It

was a

My

best regards.

Friday. The discussions
of the Sugermen proposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing, but
they do describe our present view of EEG, drugs and behavior.
pleasure being with you

on

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

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                    <text>January

l6, l968

Dr. Carl Salzman

Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase. Maryland
Dear Carl,

pleasure being with you on Friday. The discussions
of the Sugermangproposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing, but
they do describe our present view of EEG, drugs and behavior.

It

was a

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January l6. l968
Dr. Sol Goldberg
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chane, Maryland

Dear Dr. Goldberg:

It was a pleasure being with you on Friday. The discussions
of the Sugerman proposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing. but
they do describe our present View of EEG, drugs and behavior.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>January l6, 1968
Dr. Sol Goldberg
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chane, Maryland

1

.A:ynn‘nw,._.-..

-w

.&lt;.wr«

.1

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.7»;

«In

V7,,—

m

Dear Dr. Goldberg:

It was a pleasure being with you on Friday. The discussions
of the Sugerman proposal suggested that draft capies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing. but
they do describe our present view of EEG. drugs and behavior.
ﬂy

best regards.

w".

&lt;

Sincerely yours,

”

mmw-

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a“

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aural

Fink, M.D.
Professor of Psychiatry

_

Max

Hszp

�</text>
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V,

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ww‘wm

January 16, 1968

are:

:1:
,

9-4187”

.x-W:mggi

Dr. Richard Ellingson
Nebraska Psychiatric Institute

602 S. 44 Avenue
Omaha, Nebraska 68105

m?v&lt;m.w:mn

Dear Dr. Ellingson:

It

was a

My

best regards.

pleasure to participate in the Sugerman project
I am taking the liberty of enclosing copies
of reports recently prepared which summarize our present view
of the relation of EEG. psychotrOpic drugs and behavior. These
reports were prepared for the recent ACNP meetings. and are to
be considered drafts requiring additional editing.
review on Friday.

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

MF:kp

&lt;
-

,.
wt
21.1»

v
'1

Livtwrpﬁqugnwj

a'qx..ﬂExI-fgg;g

.‘ﬁ'sJS-f,‘

"1‘,
V,

�</text>
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                    <text>..

”v.

.
.

.A..

aim-«ﬂyhm

K'n'ﬂ‘xI-nvw,‘

January
Dr. Henry

Brill

narcotic Control

l5, l968

Commission

l855 Broadway

New

York, New York

Dear Henry,

pleased to enclose two copies of our report ”Naloxone
(H-Allylnoroxymorphone) in Opiate Dependence.“
I am

v

.

Further studies of naloxone are necessary. As I mentioned
available.
to you, Endo Laboratories has not made supplies
have communicated
whom
we
with
0r. Ralph Jacobson is the physician
with regard to this problem.
Sincerely yours,

«Iv

.A

Fink. M.D.
Professor of Psychiatry

Max

mmvwemnw—

‘w

MF:kp

�</text>
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                    <text>January 15. 1968
Dr. Alan

Miller.

Commissioner

Department of Mental Hygiene
Albany, New York
Dear Alan.

at the ARNMD. we have recently completed
of an interesting new compound in the treatment of
narcotic addiction. A copy of the report is enclosed. I have
also sent a copy to Dr. Brill.
A: I mentioned

a study

Further studies

seem hampered by

limitations of the supply.

This compound has been produced by Endo Laboratories of Garden City,
Long

Island.

He

would. of course. like to continue these studies.

Your

cooperation in making supplies available for further study would
be appreciated.
Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

Mszp
ENC .

�</text>
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                    <text>January l5, l968
Mr. Harry Henderson
World Wide Medical News

l30 East 59th Street

New

Service. Inc.

York, New York 10022

Dear Mr. Henderson:
We have recently completed a small study regarding the
treatment of nercOtic addicts using a new narcotic antegonist.
The compound is of sufficient potency to be of great clinical
interest. Unfortunately, the compound is no longer available
because of the expense of production since the patent is held
by a small pharmaceutical corporation.

If. after reading this report, it is if interest to

you,

appreciate your calling me regarding the necessary
releases from the institution prior to public description.
I would

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January l5, 1968
Dr. Ralph Jacobson.

w‘»

Associate Medical Director
Endo Laboratories
1000 Stewart
Garden City. New York ll533

“

av:

v"

w

Dear Dr. Jacobson:

1.?

Lawn-m7.“

Enclosed are two copies of the prelﬁminary report "Naloxone
(N-Allylnoroxymorphone) in Opiate Dependence."

inquire as to the present status of the production
of naloxone for further clinical trials?
May I

Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max
'4".-

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"
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11-;-

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                    <text>w»

.mmmw

warp.

"win!"

January

ll,

1968

Dr. William R. Tabor

A. H.

Robin: 00.. Inc.

1407 Cummings Drive

Richmond, Virginia 23220
Dear

Bill.

Enclosed is a copy of the abstract submitted to the
Society of Biological Psychiatry. Unfortunately. the abstract
was sent too late and the Program Chairman has indicated that
he is unable to include this presentation.

Nevertheless.

can and

will send

I

plan to complete this report as soon as

you a copy.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

I

�</text>
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                    <text>January

ll,

l968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue

New

York.

New

York

Dear Alain,
I look forward to having you join us on February 2.
Enclosed is a list of the seminars in psychopharmecology
for the residents and I look forward to having you discuss
with them the practices and problems of new drug evaluations.
The presentation will take place at ll 00 am at
Metropolitan Hospital (97th Street and First Avenue) in
the fifteenth floor classroom. The group will consist
primarily of first year residents and some additional
members of the staff.

.

AV:

V

w-wvauw;7-l\-

"

'~‘r

At l2:l5 pm we plan to meet with the whole staff to
present our experiences with long acting fluphenazine.
Dr. Bucci is away, but as soon as he returns he will summarize
our data and we hope we can get it to you before the presenta~

tion.

www-

'
xv:

_my:~mtrnvmr

Incidentally. I received the corrected text from the
Anchivea 05 Genenaz Payehiatay of our report and this should
appear shortly. I have called Mr. Bold and asked him how many
reprints he would like.
I look forward

-

to your participation in our program.

best personal regards.

Sincerely yours,
Fink. h.D.
Professor of Psychiatry

Max

MF:kp

My

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                  <elementText elementTextId="105588">
                    <text>January
Mr.

Gilbert

M.

ll,

1968

Barcus

Mcﬂeil Laboratories Inc.
33l0 Nostrand Ave.

Brooklyn,

New

York

Dear Mr. Barons:
I regret that your failure to call my office for the opportunity
to present your questions may have led to some confusion. You must
know that a consultation in the hall is highly inappropriate.

If I understand your question, it was whether we were willing
to undertake a clinical study of haloperidol or any other procedure
which would make this drug available for clinical use.
Please be advised that for the past year the Department of
Psychiatry has had an established committee to review recommendations
for new drugs for clinical use. This committee, the Psychopharmacology
Study Group, meets at irregular intervals at the request of the Chairman
to review the available data prior to making recommendations to the
Formulary Committee of the Medical Board of Metropolitan Hospital.
If

McNeil

Laboratories is interested in having haloperidol

would suggest that you write a letter to me and submit
six copies of any information you wish to bring before the committee.
I will be pleased to have the committee review this recommendation at

reviewed,

its

I

next meeting.

~

Incidentally. the administration of compounds not accepted in
the formulary by members of the staff is governed by the
ulotions
regarding research in humans. To comply with those regulat cos it
would be necessary to submit a formal protocol to the Research
Committee of the Medical School. the Medical soard of Metropolitan
Hospital and to the Commissioner of Hospitals of the City of New York.
For this reason. I would urge you not to distribute samples of this
compound

for clinical trial as

you attempted with me.

indicated. I would be pleased to hear
your research division at any time.
As I

from members of

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr.
.,
,w

m

me'rv-

V.

Slotnick

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                    <text>January

ll,

l968

Dr. Joseph 6. Bird

Sterling~hinthr0p Research Institute
Rensselaer, New York l2144
Deer Joe.
I

have received the supplies of cyclazocine (0.25 mg) and

placebo to match.

I think these will suffice for the remainder
of study #l. I have asked Dr. Simeon and Dr. Zaks to replace
the active medication with placebo in each of the patients and
to observe the changes which follow.
May I take this opportunity to thank you for
your thoughtfulness
in sending me such a fine holiday gift. I took this
home and my
wife and I are pleased to thank you.
My

best regards.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

�</text>
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January

ll,

«wwvv—mmrmrmmwWLWVPr—v'
,

l968

Dr. Francis Latteri, Chainnan
Pharmacy Committee

Metropolitan Hospital
97th Street and

New

First

York, New York

Dear Dr.

Avenue
‘

Latteri:

During the past few months, patients of the Mental Health
have received medication not prescribed or amounts that
were insufficient to provide for the time between visits from
the pharmacy at Metropolitan Hospital. Such events were occasional
early last year but have became increasingly frequent.

Clinic

'

staff of the Department of Psychiatry have reviewed
of the newer dosage farms of established pharmaceuticals and
would like to recommend that these be made available.
some

Also, the

May I

and would

agenda?

inquire as to the next meeting of the

it

Pharmacy Committee
be possible to have these two items placed on the

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

ﬂszp

�</text>
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                    <text>January

ll.

l968

Hr. Robert Shearman
IBM

2ll

Corporation

Montague

Erooklyn, haw York
Bear Bob,
I am sorry that I missed you during
your recent visit. but
had told me of the change in your assignment. I want'to
thank you for all your help in establishing our small computer
unit. It is exciting to realize that we are operational
and
in less than one year.
Don

May.

still some question about the demonstration in
but this should be resolved within the next few weeks.
There is

thanks again for your help and
continued success.
My

my

best wishes for your

Sincerely yours,
Fink. n.0,
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>January l0, l968
Dr. Carl Salzman
ECDEU

Psychopharmacology Research Branch

National Institute of Mental Health
5454
Wisconsin

Chevy Chase, Maryland

Dear Dr. Salzman:
The members of my staff who
attended the ECDEU meetings
week were very much stimulated to
participate in this
collaborative program. I believe the meeting
was a success
and I am grateful for the extensive work
that was done in

last

preparing the forms.

As we undertake new
studies, the forms will be included
and I look forward to the analyses
as projected.

Dr. Itil shared with me the reluctance
of the participants
to use a more definitive laboratory
rating
scale.
This appears
to me to be the only form of importance that has been
omitted.
I plan to use his and we will
process this ourselves.
Thank you

for the courtesies

you extended to

my

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

staff.

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                    <text>v

January 10. l968
Miss Karon Slotky
Copy

Editing

ﬂepartment
American Monica Association
535 horth Deartorn Street
Chicago. Illinois 60610

war

~wwm..wr:wrmwm-

Dear Kiss Slotky:
I am returning the text of our report ”Longuncting Depot
Phenothiazina Treatment of Psychosis,“ which is to appear in
the forthcoming issue of the Aachivea og Gaaaaat Raychzatag.

rsmuv'u

Please change the

0:"

Wm.”-

The

«v.3,-

.A-

name

of the coauthor to Turan

M.

Itil.

M.o.

address listed is a permanent address.

V.

wm.

With regard to the reference now numbered l6, this appears
The original text is incorrect and reference l5
ei
page be 2t.
0:
s.ou
.

l967

l 0.

The personal communication

of reference

There are minor corrections in the
In Table

text

11 was

oral, July 22,

on pages 1, 2. 9 and

”yaars" for average number of
ambiguous. That should be deleted.

I, tho subscript

hospitalizations is

In other regards the

text appears correct.

Finally. I believe the layout can be improved. The layout
shows the report beginning on the left side of the page. This
is awkward and if at all possible. perhaps this report should
two of the results and the
start on the right side. Paragraph
4
do
go together. If we start on
figure which now is on page
a right~hand page than the first paragraphs of the rasults
will appear on a page facing the figure. I would also suggest
a realignment of those pages so that tho figure and the legend

�Miss Slotky

«2-

January 10, l968

appear on the upper left~nand side. in the location on page 3
where Table 1!! now appears. By continuing the copy so that
extends on the loner half of the left column and the upper

it

half of the right column. Table
of the right column of page 3.

111 can occupy

the lower half

For page 4. Table IV might suitably occupy the upper righthand part of the page so that the text fills in the left side
and all of the left column. The comment would then appear under
Table IV and would continue to page 5. It would not be necessary
to change page 5.

if

the recommendations for page

The

reprint order is enclosed

are unsatisfactory an:
in the lower half of page 4
filling out the right-hand corner, allowing the copy to complete
the left side and the upper right part of the page.

alternate approach is to

h

,

“am“.

,.,‘.

.—

_-;&lt;«

.n
.urv

_

-,
:-

will follow.

4

have Table IV

and a formal purchase order

r,

Thank you very much

“urea-wry;

for your assistance.
Sincerely yours .
Fink, ".0.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January

l0. l968

Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39

Dear Taran.
Enclosed is the galley protf and the letters on the
fluphenazine paper. I have made all the corrections that
they have requested and would ask only that you please check
Table I. I think that “years“ under the average number of
hospitalizations is unnecessary.
I am ordering 1,000

for everybody.

If you

directly to

reprints,

which should be enough

have any additional changes. please send them
Miss Slotky with a copy to me. My best regards.

Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

Mfzkp

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                    <text>‘M’u":

u

January l0. l968

wrw.

Irv“

Dr. Jonathan 0. Cole

Boston State Hospital
Boston. Massachusetts
Deer Jonathan,

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmecology at the
New York Medical College on March l5. The seminars are held
at the Metropolitan Hospital (97th Street and First Avenue)
in the conference room on the l5th floor. at ll:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss the clinical antidepressants.
he

our

I

will defray your expenses and there will be an honorarium.
will call you before March l5. Thank you for accepting

invitation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>32‘.

V-w

Mr

was
'u.

January

l0, l968

Dr. Charles Shagass
Temple University

Department of Psychiatry
Philadelphia. Pennsylvania

Dear Charles.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
ﬂew York Medical College on April 5. The seminars are held at
the Metropolitan HOSpital (97th and First Avenue) in the
conference room on the 15th floor at ll:00 a.m.

s-‘wrrwx-wws

;~

I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss "Drug Response in

Classification.“
we

our

I

will defray your expenses and there will be an honorarium.
will call you before April 5. Thank you for accepting

invitation.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 10. l968
Dr. Nathan 5. Kline
Recklend State Hospital
Orangeburg, New York

Dear Note.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
New York Medical College on June l4. The seminars are held
at the Metropolitan Heepital (97th Street and First Avenue)
in the conference room on the l5th floor at ll:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss “Psychopharmecology

Research in Private Practice."
We

I

will defray your expenses and there will be an honorarium.
will call you before June 14. Thank you for accepting

our invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January 10. 1968
Dr. Heinz E. Lehmunn

Clinical Director

Douglas Hospital
6875 Lasalle Blvd.
Verdun, Quebec
Canada
Dear Heinz.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
New York MedicallCollege on May 3l.
The seminars are held
at the Metropolitan Hospital (97th Street and First Avenue)
in the conference room on the 15th floor at 11:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss “Psychological Tests
and Drug Effects.“
We

I

will defray your expenses and there will be an honorarium.
will call you before Hey 3l. Thank you for accepting

our invitation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 10, 1963
Dr. Daniel Siiverman
269 South 19th Street

Philadeiphia 3. Pennsylvania

Dear Dan,

Enclosed

American

EEG

discussion.

is a final copy of the presentation at the
Society. as well as modifications of the
I

trust this is satisfactory.

for your patience.

Many

thanks

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Mex

NF:kp

�</text>
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              <elementText elementTextId="32612">
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                  <elementText elementTextId="102494">
                    <text>January 8, l968

Arthur J. Lunny
Chart Paper Sales
Grass Instrument Company

Mr.

Quincy, Massachusetts 02169
Dear Mr. Lunny:
boxes

On

our outstanding oeder of

to

my new

laboratory.

EEG

paper. please ship

25

Dr. Max Fink

Department of Psychiatry

Metropolitan Hospital,

First

ﬂew

Separately

December 29,

we

Avenue

at

Room l5A9

97th St.

York, New York 10028

are sending you an additional order, dated
100 boxes. Please bill us promptly.

for another

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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              <elementText elementTextId="32617">
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          <element elementId="39">
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              <elementText elementTextId="32622">
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              <element elementId="52">
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                  <elementText elementTextId="102495">
                    <text>January 8, 1968
Mr. w. H. Bold

Manager, Clinical Research Associates
Squibb Institute for Medical Research
New Brunswick, New Jersey 08903
Dear Mr. Bold:
an

The Prolixin study is going well. He do, however. need
additional supply. of oral Proloxin. l mg. would you

kindly send us

4

bottles.

500

Thank you very much and

tablets each?

my

best wishes for the

New

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Year.

�</text>
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          <element elementId="50">
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              <elementText elementTextId="32624">
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              <elementText elementTextId="32632">
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                    <text>‘w-"C‘LWJ‘.

Karly—71"!”

,

.77.

Harem-www-

January 8, l968

raw,m&lt;~A-w~‘-‘v'

.

0r. Jerome Levine. Chief,
Barlow Building

PR8

5454 Wisconsin Avenue
Room lGCOl

Chevy Chase, Maryland

Dear Dr. Levine:

RE:

I am writing with regard to rebudgeting
(EEG and Human Psychopharmacology).

MH-l3358‘0l our

account 4l-382-l

MH-l3358-0l and ~02

In reviewing the expenditures for 1967 there are $5500 in
unexpended funds which may be carried over into l968. A revised
25-90~l (Section III) is enclosed. THIS XS UhAUDITED AND COMES
FROM MY RECORDS ONLY.

This sum should be used to reduce the award of Mh-lBSSB-OZ.
We

be aware

also reviewed the request budget for l968. You may
that HH-l3003—02. a grant to complete studies at the

have

University of Missouri runs concurrently from 9/1/67 through
8/l/68. Except for some consultation and travel items, it has
not been necessary to utilize this budget and $9,000 remains.
This will be used during the first few months of l968 and it is
suggested that MH«l3358~02 be reduced in this amount.

revised request budget for the ~02 year is attached. The
sums carried forward and the balance of MH-l3003 will be used to
reduce the personnel item.
A

These modifications in the l968 budget meet with the approval
of the executive administrator of the Department of Psychiatry and
the Vice President. both of whose signatures appear below.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max
APPROVED:

B. §chwartz
l.Executive
Administrator

Department of Psychiatry

“FL Haydn Morgan. Vice

President

Research Administration

�</text>
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                    <text>January 2, l968
Dr. Hilliam Karliner

Franklin Road
Scarsdale, New York
20

Dear

Bill,

Miss Harriet hernstein had a repeat electroencephalogram
on December 28. The record indicates that she received dilantin,
390 mg/day and Tofranil. 150 mg/day. She appears less depressed
and is in good contact. Emotional lability is no longermmanifest.
The electroencephalogram was repeated (#406). The rhythms
were symmetric with the same amount of alpha and beta activity
as previously. The amount of theta activity was increased and

the beta activity

was more prominent

in all leads.

0n hyperventilation, high voltage spike and wave
activity
appeared for let seconds after 180 seconds and after llO seconds.
There was no additional seizure type activity in the record.

There is no evidence of increased seizure

result of imipramine.

would suggest

it

activity as a
status,

In view of her improved mental

that she continue

on imipramine.

In the event that you plan to discontinue her medications

may

be useful

to repeat the

dose of imipramine.

EEG 7 ~

l0 days after her last

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

I

�</text>
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                    <text>May

Dr. Paul Blachly

University of Oregon Medical School
Department of Psychiatry
3181 S.N. Sam Jackson Park Road
Portland. Oregon 97201

’

Dear Paul,
Thank you for your letter of May 22. I would be pleased
to participate in the Institute, especially since Dr. Jaffe
will also be present. The idea of such an institute is new
to me and I probably will plan to be there on August 14 and 15.
I will plan to discuss the psychopharmacological treatment
of opiate addiction, emphasizing some of the newer experimental

approaches.
Your

run our

visit

encouraged us very much and I am planning to
ECT during the forthcoming week.

first monitored

Thank you

for your kind invitation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

’

"
~‘

.“"
‘

:‘ﬁw'vweanﬂhmw

kifﬁﬂW.-/

_

,W

ran?

29, 1968

�</text>
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                    <text>wv-r-n

awn

May

29, 1968

Dr. Ali Keskiner
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear

Ali,

He have just received the reprints of the long acting
phenothiezine report. Separately, Kathy is sending you a
large supply of reprints and tear sheets. He will answer
some of the re rint requests here. but if they get to be
too many we wi l send them on to you. Please fill those
that come directly to you. since we are keeping a small supply
of reprints.

“Ii-w

imam-v:—

vrpv'i‘lv’w'z'vl'ﬂvx

.v

'(F‘WW‘Q‘K'

y7;

www-‘WW

"tjl'rﬂjr

ay-

-r--

.1»

Tepkapi
My

is doing will as

you

will hear separately.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>May

28, l968

Dr. Paul de Haen, Inc.

ll

New

Nest 42nd Street
York, New York l0036

Dear Dr. de Haen:

Enclosed are the terms that I believe would
cover the range of psychoactive drugs of interest
to psychopharmacologists. I would like to ask you
for an estimate of the cost for a subscription to
the 'de Haen Drugs in Use" from the beginning of
your collection to date and an annual subscription
rate for the compounds in these classifications.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

A

“Song”

�</text>
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                    <text>'"I
v-'
»

x’ymwwl-ﬁ'ﬁf"

May
wmwwwﬂ

cw.

_«

:jlm

w-UW;

W;

27, l968

Dr. Leo Alexander
433 Marlborough Street
Boston l5, Massachusetts
Dear Leo.

Enclosed is an abstract of a presentation for the session
the forthcoming October meeting of the
C.I.N.S. in Milan. As you know, this subject, the relation of
EEG changes to behavior with psychoactive
drugs, has been of
great interest to me and my colleagues since l954. The recent
symposia at the Society of Biological Psychiatry (1965) and the
on psychopharmacology at

"m!

'cwm

:
aw

(l966) on the dissociation problem laid the groundwork for
these theoretical summaries.

CINP

Thank you

for your consideration.

r

Sincerely yours,

Amt-arm“,

K

Fink, M.D.
Professor of Psychiatry

Max

Mszp

cc:

Prof. C. L. Cazzullo
Prof. T. Ban

�</text>
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                    <text>May

24, l968

Friedrich Hoffmeister
Katernbergerstrasse 262
Huppertal-Elberfeld
Dr.

Germany
‘

Dear Dr. Hoffmeister:

.

_,

,.,‘.

.,...w

w.“

.‘a‘wuqu

It

pleasure to hear your report at the CINP and to
discuss the problem of narcotic antagonists with you. As I
indicated, we are particularly interested in the use of antagonists
in the treatment of opiate dependence. Two reports of our work
have already appeared. and a third is in press. I am enclosing
preprints of each of these.
was a

aspects have been of special interest: the potential

Two

use of cyclazocine as an antidepressant, and the expense and
short duration of action of naloxone.

With regard to cyclazocine as an antidepressant. we were
stimulated to these trials by the similarity of the EEG patterns
of acute and chronic cyclazocine to that of imipramine. In two
clinical trials. we are impressed that cyclazocine is indeed an
and the preliminary reports of that work are
antidepzessant
enc ose
.

But it is the antinarcotic activity of naloxone that holds
the most promise. Because of its short duration of action. not
exceeding 4 hours in our trials, it may not be useful in clinical
treatment. We are encouraged. however, that other antagonists
similar to naloxone may be available in the chemists laboratories compounds with similar potent antinarcotic activity but of longer
duration - hopefully with as long a duration of action as the
long—acting depot fluphenazine enanthate or decanoate. We are
interested in hearing from you whether Bayer has such a compound

available. and if so. whether it is available for clinical trials.
there other laboratories that may have a long-acting narcotic

Are

antagonist?

�Dr. Hoffmeister

I should

-2-

May

also like to take this Opportunity to invite

24, 1968

you to
next you visit the Uiited States.
I would like to review our programs and to arrange for you to meet
the Chairman of the Department of Psychiatry, Dr. Alfred M. Freedman.
who has stimulated these studies.

visit

our

clinical facilities

Thank you

when

for your assistance.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp
ENC .

�</text>
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                    <text>ﬂay 23. 1968

Pref. Dan H. Espiin
University of Utah
Salt Lake City
Dear Dr. ESpiin,
Your

recent report.

"A

Techniques Used to Study Drugs”

Critical Appraisal of Eiectrophysioiogicai

at the hiami

Beach symposium is
I
unabie to attend that
was
Regretfuiiy,
meeting and I am writing to ask if a prepriat may be avaiiahie.
For the past decade I have been specialiy interested in the
induced £56 changes in man by the variety of psychoactive drugs,
and have focussed on digital computer analytic methods, notabiy
period analysis. I look forward to reading your views on this

of special interest t0

me.

important problem.
Many

thanks.
Sincereiy yours,

Fink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>23. 1968

May

Prof. Jean Babe»
Ciiniqua Psychiatrique
Liege. 8eigiqua

'

Bear Professor Baton.

It

kind-of you to consider

was

my

participatian in the

fbrthcoming ”Interdisciplinary ﬂeet on "unrelentics” in May, 1969.
i mania be pleased ta participatn. and 109k farumrd to doing so,

subject to the vicissitudes of the prnsent restrictions

on the

use of our funds for internationli travel. as yam may have hanrd,
since March 11. 1968 we have not been permitted to use any of the
usual fund: for such tnivoi, tad wt viii have tn try to obtain
new funds from other than our ntuai sources. As this it a new
situatien far us, I an unabio ta be optimistic at the present time.

interests

I did enjoy meeting your
and by

bit futility

in

tan,

who impressed an by

war ianguage.

Ha

his

would be giensed

consider an appiicatien from him to continue his studies in our
iaborateries which are deveted primarily to studies of the effects
of psychoactive drugs on the human EEE.
Again.

my

thanks for your kind

to

invitation.
Sincereiy years.

Fink. M.D.
Professor of Psychiatry

Max

”Fl

I

�</text>
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                  <elementText elementTextId="102505">
                    <text>\\
May

Dr. Barnard C. Giueck,

Director of Research

22. 1968

Jr.

Institute for Living

Hartford. Connecticut
Dear Bax.
My

associates

and I look forward to

visiting your facilities

Shapiro. the director of our Biomadicai
Information Processing center viii Join me. as wiii three of our
proqrammers and one of my associate psychiatrists.

on Monday. June 3.

Don

In addition to the centrai processing

terminais in the clinicai units.
to visit with Dr. Stroebei.
Thank your

I would

for your assistance.

facility

iika to

My

and the
have an opportunity

best regards.
.iSincareiy yours.

Hal Fink.
MF/

3.0.

�</text>
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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

�</text>
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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

�</text>
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                    <text>May

10. 1968

Dr. Michael C. Barry
Medical Department

white Laboratories. Inc.

Ksnilworth.

New

Jersey 07033

Dear Dr. Barry:

Enclosed

is

a proposed Statement of

Investigator

Form (FD l572) for the high dose fluphenazine study.
In addition. I am enclosing copies of the report presented
at the CINP and a summary of the proceedings of another

related confsrencc in Sitges, Spain.

Please edit these and the proposed project to your
satisfaction. I look forward to hearing from yen.
Sincerely yours.
Fink. NJ).
Professor of Psychiatry

Max

HF:kp

cc: Dr.

Itil

�</text>
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            <elementTextContainer>
              <elementText elementTextId="32761">
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  <item itemId="3277" public="1" featured="0">
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        <authentication>baa2fd3270ddca714f5fb8195e54e0f4</authentication>
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                  <elementText elementTextId="102509">
                    <text>..
,-.

.

“Er—v

mm».

w

May

’ru
-rrr

1
raw

your

;»~:

.5,,

l0.

1968

Dr. Robert Summit
St. Paul-Ramsey Hospital
St. Paul. Minnesota SSlOl

V'er

s:
vr-v

,rrwa'm—H'u

w

mnww

ﬁv—rmwwm/mw

W:

vmm-

Wu:

W:

Dear Dr. Gumnit:

Enclosed is an abstract for your consideration for the
forthcoming meeting of the American EEG Society.
I

trust this is acceptable to

Thank you

for your consideration.

you and your Committee.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Hey 10. 1968

Dr. E. Ned Schultz
Director, Medical Affairs
E. R. Squibb &amp; Sons. Inc.
460 Park Avenue
New York. New York 10022
Dear Dr. Schultz:
On my

enclosed

return

summary

would be useful

from the Sitges conference I prepared the

for presentation to
to you.

my

staff.

Perhaps

it

take this Opportunity to thank you for your kindness
during the meeting and your recent consideration.
Hey I

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>May

10, 1968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

draft

is a
I have

copy of the summary of the Sitges
Symposium.
prepared this as a summary for my staff,
but
may be useful if you plan to prepare a volume of the

Enclosed

it

Proceedings.

that

you do prepare a volume, we would
like to summarize our observations in New York more adequately
than are represented in this summary.

In the event

As I

indicated

Dr. David Graubert

on

the phone. one of

my

is anxious to undertake

a

former associates,

clinical trial

of depot fluphenazine and if such a study could be structured,
we would be pleased to process the data in our center or assist
in any other way.
Thank you once again
the symposium very much.

for your kind remarks.
My best regards.

I

enjoyed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>;

E

Mira-7' ‘

5/

4

W
T0:

Dr. A. h. Freedman

FROM:

Dr.

M.

Fink

DATE:
SUBJECT:

May

l0. l968

Application of Dr. Dinnerstein
for research program on marijuana.

The theoretical problem posed by Dr. Dinnerstein is a
relevant and important one. especially the desire to measure
the effects of marijuana on automobile driving behavior.
This has public health implications as well as some theoretical

value.

The

large -

Drug

slightly

choice of subjects is good but the number seems unusually

250

trials is

a very

large sample.

administration is clear and perhaps might be modified

by drug experience.

test battery is

adequate to the theory. The number of
which these are going to be administered
is probably too large. but I assume Dr. Dinnerstein plans to run
some trials first and then select the most interesting test models.

tests

The

and the time

at

Criticisms: Perhaps the biggest criticism is the comparison
with ethanol for this puts the study on the basis that the ethanol
group was selected for some logical reason. This is not clear in
the text and I do not think the two drugs are either opposed to
each other or are necessarily similar to each other or that the
findings in a comparison bear any necessary relationships to each
other. Because of this comparison group, the number of subjects
.

becomes so
The

large.

section of significance of research leads

that the selection of ethanol or

me

to feel

even the study of cannabis
arises not from the public health interest. but from the popular
enthusiasm for cannabis. I would have thought that a study of
motor performance under cannabis on acute and chronic administration
of cannabis would contribute to our understanding of its physiology
in a shorter time than the proposed study design.
Dr. Dinnerstein does not make clear that he is aware of
the difficulties of obtaining permits to carry out marijuana
research.

�Dr. Freedman

~2-

May

10, l968

It is probable that our own acute and
- Behavioral studies could be significantly amplified
by psychomotor studies such as outlined by Dr. Dinnerstein and
a collaborative study might be considered if the goals were
simply stated.
Recommendation:

chronic

EEG

,

_

Considering the present funding policy of NIH, I think

this application is too large to

be reasonably supported and
the Research Committee might be warranted in recommending a
less anbitious program as an initial experience with marijuana

for this investigator.
MF:kp

�</text>
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                    <text>May

9, 1968

Dr. Perry Black
2006 South Road
Baltimore, Maryland 21205
Dear Dr. Black:

Enclosed are corrected pages for the manuscript
"Drugs, EEG and Behavior" following your suggestions

0:

‘mrr-wu—

—-

yesterday.

free Levin for the whole
volume, although if reprints are to be made available
if the publisher
to the authors, I would be grateful such
use, set up my
would, as partial compensation for
reprints with this paragraph as a frontispiece.
Table II should be corrected so that the heading
You may

use the quotation

for:

.

Ia

Mai

nly increased s].oving
Alpha
Seizure Activity

Increased
It With
Ic With Increased
IIa With Increased
IIb With Decreased

Amplitude
Amplitude

in each column should be listed alphabetically,
but the parentheses should be maintained wherever indicated.
of
Also, in Table II the type selected for the title
be
should
class IV and V, alpha increase, alpha decrease,
and
Page
7,
III.
for class I, II
the same as the typeface
h marked in italic are to be rpplaced by
3
and
paragraphs
the paragraphs appended.
On page 8, a footnote should be added with the asterisk
after the word "phantastica". The footnote is appended.
EEG Applications” should
The title on page 8, "Clinical
The drugs

—

be

deleted.

page 9, the two paragraphs relating to the
should be replaced by the paragraphs appended.
On

deliriants

�-2-

Dr. Black

references
as follows:
The

May

on page 2 and 3 can be

at 3;. Digital
Psychophernacology.

9, 1968

brought up-to-dete

Analyses in
In Kline, ﬂ. and Leeks E.
(Eds) Congntere and Electronic Devices in Pezchietrz,

Fink

Grune and

Computer

Stretton, H.Y., p.

EEG

109—123, 19

.

Itil, T. and Fink, M. EEG and Behavioral Aspects
of the Interaction of Anticholinergic Hallucinogen:
with Centrally Active Compounds. In Bradley, P.
and Fink, M. (Ede), Antioholiner ic Dru e, Eleevier,
Amsterdam, p. 1&amp;9-163, 1937.
The citations should be changed on page 8 from Fink 35 e1.
(in press [a]) to Fink 33 e1., 1968. The reference to the
other citation was changed in the section on deliriente.
Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>my 9,

Ir.

Richard A.

1968

May

Division of the Social Sciences

West Texas State Unimity
Canyon, Texas 79016

Dear 1r. Lunacy:

Ymmletteraddreeudmminmmimmstbem

mivadinNawYmk. Imovodm‘twoyeareago. Ian
tﬂdngﬂulibwtyofwxdﬁugyamlemmm.mmm,
Associate Professor of Psydxiatry at the University of Miami

SdnolofMadicinearinWymomtmthimformyhelp

trutmyasaociatoaemgivoyou.

Inﬁnevmtmisoutof

tomyoumnywiahtomachm.J.M.C.}bldenatt}nm
institutim.

Sincerely yours ,
Pink, M.D.
Professor of Psydziatry

Max

MF:kp

cc: Dr. Ali Keakiner

Institute of
Mami
SHOO
Arsenal St.

St. Innis,

Wm

mam 63139

�</text>
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«.

.1

,mvyu

nr'r‘p'twvw

-v~mwm',wv"~

'A-WE'W'A‘tw-w-

"I
V"

my 9,

1968

Dr. Richard A. Lindsay

Division of the Social Sciomu
State Urdvamity

West Texas

Cmyon, Texas 79016

mm Lunacy:

Ymmletmaddresudmminﬂissom‘imjustbem
moivodinNewak. Immmycmago. Ina
taldngtlnlibu'tyofmdingywletwmm.mxwkiner,
Associate Noam of Psychiatry at the Univmity of Miami

Sdmlofhdicimuﬂlmostymoontaothimformylulp

thatmyasaociatescmgiveyou.

Intlncvmtmiswtof

tamymmywiahmmachw. .H.C.Ho1dmatthem
instim‘tim.

‘

airmen yours ,
Max

Pink,

M.D.

Hofessor of Psychiatry

MP:kp

cc: Dr.

A11 Knsldner

Miami Institute of Paydﬁatry
51:00 Mam]. St.
St. Innis, Miami 63139

�</text>
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Hay

8, 1968

Paul de.ﬁaen, Inc.

ll

New

West

Nan Street

York,

New

York 10036

Dear Mr. de Haen:

I am interested in the "Drugs in Use" service
and possibly the "Drugs and Research". I would be
grateful for a quotation.
You may recall that we discussed this at the
recent meeting in Atlantic City of the American

College of Clinical Pharmacology and Chemotherapy.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max
MF3kp

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                    <text>'

a.”

w
v.

._~.--’~

-..-....-....

‘

.‘V

May

Henry

M.

a,

1968

Stretton, Inc.

381 Park Avenue South

New

York,

New

York 10016

Gentlemen:

I would like to have two copies of the recent
issue of Comprehensive Psychiatry devoted to computers
in psychiatry. I understand there is a charge. Please

bill

us.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

,7

Avatar".

'
tuna-tr

.1.,

,v

.
-

"wan-‘-

&gt;mww

-.

.i

an"

:uwewwgrx

:4

MF:kp

�</text>
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                  <elementText elementTextId="105596">
                    <text>Vm‘m.wvmr

W imam-qty“ .u .w”
1‘

..

_T...,.v.,..‘...m.n.,‘,—»,

,‘Tmr.

-.

u-

t,_..

47...",

._\

.,

k

.w

v.7 .1,

.

w. ,,.

_

_

&gt;

-.

.0

"n.

-.

Irv&lt;=lm

,,
mun—w

w,

v
-

___.~..—,...—w-

May

a,

1968

Dr. David N. Greubcr't
3 Sl'xelter Rook Road
Manhasset, Long Island 11030
Dear Dr. Gmubert:

It was a pleasure talking to you on Sunday. I an pleased
to enclose a tearsheet of an article on fluphenaaim that my
associates and I have recently published, as well as a copy of
the swam-11y of the proceedings of a recent meeting held at
Sitges , Spain. In addition, copies of articles by Blachly
and Kurland are enclosed.

Fluphenazine enanthate is available as a oonmemial
5 cc ampules of 25 mg/cc.

preparation in

I

study.

am

also enclosing a

copy

of the protocol of our ongoing

In the event you would like to undertake such a study, I
to assist you and will contact the representative

would be glad

of Squibb.
My

best mgaxds.
Sincerely yours ,
Max Firﬂt, M.D.

Professor of Psychiatry

MP:kp

cc: Er. Marital

�</text>
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                    <text>g—Mv-"ﬂm

May

a,

1968

Dr. Fletcher Owens
A. H. Robins Company
11407 Cunmings Drive
Ridmcmd, Virginia

Dear Dr. Owens:
Enclosed is a copy of the report which we recently
read both in Tanagona and in Atlantic City. I believe
it will be published in the Proceedings of the CINP.

Sincemly yours ,
Max

Pink,

M.D.

meessor of Psychiatry

HP:kp

�</text>
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                    <text>May

a,

1968

Dr. Eugene Laska
Rockland State Homital
Orangeburg, New York
Dear Gene,

I have received the reprints of our article in your
I am writing to inquire whether copies will be
sent to authors.

book and
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

14?sz

-n-—4v

“,1

‘
,r

Tuwyl

‘13-?“

�</text>
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                    <text>May

8, 1968

Dr. Leonard Brahan

Endo laboratories
1000 Stewart Avenue
Garden City, New York 115333

Dear Dr. Bmhan:
Enclosed

is

a.

copy of the report which we recently

read both in Tarragom and in Atlantic City, I believe
it will be published in the Proceedings of the CINP.
Sincerely yours ,
‘

Fink, 1w.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>m-

--'-

-1W~'rv4-mrm'-‘v~o

-r‘

v.1...

‘2

May

:W;db!'ii.))~"~"'."‘r';ﬁ“-

8, 1968

Dr. E. N. Whitman

v»

Hoffman

459F‘W'5

Nutley,

We)»,

New

Inc.
Jersey 07110

p.»

'rr‘aaz—rv

V

:
-

w.».-,—

merww:

Dear Dr.

Whim:

Implomdtohvoﬁnwmmtymdimsw
mﬂmymmagaininmlmticcuy.

NW1

Yammntimﬂntkbffmnmwm

supplies may

WE‘"

”

1-425,"

r

var

'

*A

'5

become

pmdming

is of special interest to us. If

available for emerimntal use,

would

ympleaseletmhmtowrmmmywrite. Hammadma

towxdwtdmsmhstudies,mwehavezmt1ypmposeda
studyofthemscimuc‘beristicsofﬂﬁsdmg. Unfortmately,

mfirxiﬁntttnauppliesmlinitedandmmamdous

obtainamhfmmtewrsmm.

.
_

Iwuldlﬂmtophntoviaityouinmmmlwrﬁe

ﬁrr'm-w-Wrr»

toyouagain.

eczwr'i-w;

Sincerely yams .
Max ﬁnk, NJ).
Professor of Paychiaty

Mqua

cc: Dr. A.

M.

W

�</text>
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                    <text>May

a,

1968

Dr. Vincent Cremnta

(has. Pfizer 8 Co.
Grotm, Cormotimt
Dear- Vince,

At a recent meeting of the Fonmlary Committee

of Metropolitan

Ibspitalcnthemcmunendatimofthecminnmoftmmpartmnt

of Psyclﬁatzy and the Clairmn of the Psycl'xophamnoology Study
Group, ﬁziothixenewasplacedmthef‘omularycftheﬁospital
for- one year trial.

it

would
have remanded its use to our maidcnts and
he very helpful if supplies could be made available for their
We

use through the pharmacy of Metropolitan Hospital. Mrs.
is the chief pharmacist.

me

A. Cruzado

to have an adequate
it be possiblc for you to
clinical supply made available to tho plumacy?
Would

Sincerely yours,
Max

Pink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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              <elementText elementTextId="32912">
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              <elementText elementTextId="32913">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>3'

.
.ﬂmuMw-

“-3,,“

-.

I}

May

Dr. Robert W. Ballard
Medical Director
McNeil Laboratories,
Carp Hill Road

a,

1968

Inc.

Port Washington, Permsylvania 1903“

DearDr. Ballard:
At a meant meeting of the Pomulary Oaunittae of Metropolitan
Hospital on the recamBndaticn of the Claiman of the Department
of Psychiatry and the Clair-nun of the Psychophannacology Study Gimp,
Haldol (haloperidol) was placed on the Fomnlary of the Howital

for six nmths trial.

Wehaverecormendsd itsusetommmsidentsanditwwld
if supplies could be made available for their
use through the pharmacy of Metropolitan Hospital. Mrs. Quzado
is the chief pharmacist.
be very helpful

Would it be possible for you to arrange to have an adequate
clinical supply made available to the pharmacy?
Many

thanks.
Sincerely yams,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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              <elementText elementTextId="32918">
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              <elementText elementTextId="32923">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102521">
                    <text>May

8, 1968

Dr. Fletcher (Mans

A. H. Robina Cmpany

Cumings Drive

11407

Ridmmd, Virginia
DearDr. Owens:

At a recent meeting of the Formlary Committee

of Metropolitan

Mitalonﬂmemmmtimofthecminmofﬁwnapumtof
Psydﬁatxyandtmauimmofﬂnhycmphazmcology Study Grow,

was placed
1:57th
tr .

on the Foruulmy

of the Hmpital for six mutha

it

We have moannended its use to our residents and
would
be very helpful if supplies could be made available for their
use trmxgh the pharmacy of Metropolitan Hospital. Mrs. A. Cruzado

is the chief

pharmacist.

Would it be possible for you to arrange to have an adequate
clinical supply (emlusive of the special study in the treatment
of narcotic addicts) made available to the pharmacy?
Many themes.

Sincerely yours ,
Max

Pink,

M.D.

measaor of Psydﬁatxy

Mszp

�</text>
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                    <text>May

8, 1968

Dr. Ralph Jacobean
Endo

Laboratories

1000 Stewart Avenue
Garden City, New York 11533

Dear Dr. Jacobean:
Enclosed

is a

capy of the report which we recently

read both in Tarragona and in Atlantic City. I look
forward to receiving supplies of naloxone in the smmer
and hope that we can continue our studies.
My

best regards .
Sincerely yours ,
Fink,
m
Professor of Psychiatry
MOD.

MF:kp

,
pun

.

mlml-w—gm-wr-

nrﬂW'M'.

‘Wmvfa‘ir'E-e

I”

�</text>
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—

nIWMr-w-r

'Vnu‘ym.

wu—

May

Dr. Joseph G. Bind
Sterling Winthrop Research

chsselaer,
Dear-

New

York 121%

a,

1968

Institute

Joe,

Bmlosad is a cepy of the report which we
mad both in Tarragma and in Atlantic City. Irecently
believe
it will be published in the Proceedings of the GIMP.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>un-

-‘.-

-,

,v.‘11';~.

v

“.rgvdm—

n

”W,

7

?

May

8, 1968

Dr. Herman C. B. Denber

Manhattan State Hospital
600 East 125th Street
Wards
New

Island

York,

New

York 10035

Dear Hy,

I regret that I missed Dr. Teller's presenta—
tion at the GWON, but I recall your saying that a
draft of his paper might be available. If so, I

would be

grateful for a copy.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>May

8, 1968

Dr. Magno J. Ortega
Chief of Professional Education
Department of Mental Hygiene
Napa State Hospital
Imola, California sussa

Dear Dr. Ortega:
Thank you very much for your kind invitation
plan to be
to visit Napa State Hospital. I do not EEG
Society
in California again until the American
meetings in September. Perhaps I could visit you
at that time and will write to you later this summer.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>May

Dr. Alfred

M.

8, 1968

Freedman

Chairman, Department of Psychiatry
New York Medical College
5

Best 102nd Street

New

York,

New

York 10029

Dear Al,
and

Dr. William Karliner is a practicing psychiatrist
in somatic therapies with offices both
specialist and
He has an extensive practice
New York.

in Westchester

at Gracie
He

and has

Square Hospital.

has heard of the reorganization of Grasslands

indicated

facility.

an

interest in participating in that

In the event you decide on the appointment of
an acting director, it might be useful to invite
Dr. Karliner to participate in the planning, development
ﬁe
and administration of a somatic therapy unit. He him
commend
would
and
I
do
so
to
eminently qualified

to you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF:kp

�</text>
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                    <text>—

aw.

m

‘.

,.,,

a,
.q.

4,7,.

7-5,.»

5

“Armor

1-.

avvm.»1wFM-W

.;

mc?’

van-1

8, 1968

May

A
~r

v.1:

.
Fin

Dr. Jerome Levine
1‘1;aqm’,¢wilﬁfi

KW“

15.1”,

Psychopharmacology Research Branch

National Institute of Mental Health
susu Wisconsin

Chevy Chase, Maryland

:Tz'Wn‘WW‘

1‘

i“

Dear Dr. Levine:

I

ﬁrm":

"~
.

w

.‘ﬁ.

Q'M‘E-w

&lt;.
"Ir/z.“

”AMA”;

”tartar-

am

writing with regard to MHl3358-02 and the

deletion of foreign travel. The date of issue of
the actual grant award was “/19/68, although the
project period was 1/1/68 through 12/31/68. You
may recall that I had inquired as to the delay in

receiving this renewal award letter because it
seemed necessary to visit the University of Istanbul
during the month of February to provide the data for
presentation at the 1968 meeting of the CINP.
Based on our understanding that the revised
budget request had been approved by the Council,
the Chairman of the Department approved this foreign
travel. The total cost was $779.05.
I would like your assistance in having the
approved budget for HH—13358 revised to include
this sum ($779.05) for foreign travel in 1968.
No additional foreign travel has been or will be
undertaken under this grant.
Thank you for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFikp

cc:

Mr. Schwartz

�</text>
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                    <text>May

8.

1968

Dr. Turan M. Itil
Tophapi Serai
Istanbul, Turkey
Dear Turan.

selfexplanatory letter from Dr. Bailey.
I called him today and he will entertain an application
from us, approximately two years. perhaps three, in the
order of $l8,000 - $25,000.
Enclosed

is

a

Please plan on your return to stop off and if you
wish. the International Association would be pleased
to make such an application.
Alain Sanseigne called to say that
available for the Istanbul study.

no funds were

are still working to hard and trust that you are
enjoying yourself. My best regards.
we

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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May

Dr. William Zung

Veterans Administration Hospital
Durham, North Carolina 27705
Dear

Bill:

I trust the enclosed check will defray your
expenses for your recent visit. We enjoyed having
you very much and look forward to having you visit
at your convenience this summer.
I will be Chairing the Sunday afternoon session

of the Society of Biological Psychiatry and at
Dr. Koella'e suggestion will call on you early in
the afternoon.
My best regards.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

enc .

�</text>
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.W'Jn

Aw...”

..

1v

May

7, l968

Dr. Norman Pitts
Chas. Pfizer &amp; Co., Inc.

Groton, Connecticut
Dear Dr.

Pitts:

Separately I have sent you the summaries and behavioral
rating scales of the subjects receiving Doxepin in our initial
Mental Health Clinic study. Enclosed is our interim report
which is our summary of this information.
I

trust these are helpful.
Sincerely yours.

F
1‘

.
I“

Max

I

amwuwusql

.MWVL.‘

w“.

;
1],.

w

-,
,
.

"14:54“

raw-r"

‘RM‘W‘Marwwwwmil/Mm!xi»

Fink, H.D.

Professor of Psychiatry

m-“

Mszp

�</text>
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                    <text>May

ﬁiss

7. l968

Sage Roson

Administrative Secretary
American College of Clinical Pharmacology
and Chemotherapy
230 North Broad Street

Philadelphia, Pennsylvania

l9102

Dear Miss Rosen:

the sessions of the American
If the College
is able to defray the expenses, I would suggest the
following:
I very much enjoyed

College no Friday and Saturday mornings.

hotel

Sl2.36

Meals

Transportation

(car)

8.00
20.00

$15733’

Thank you very much.

Sincerely yours.
Fink. “.0.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>May

2. 1968

Dr. Daniel P. Bobon'

Assistant

A

L‘Universite
l4

Quai de Rome,

Liege, Belgium

Dear Dr. Bobon:
my

Enclosed are representative reprints of the studies from
laboratories, as well as two preprints of work that may be

of particular interest to you.

It was kind of you to consider an invitation for your
forthcoming roundtable in Belgium and I trust that these
reports will give
In the efent

you an idea of our work.

that

you consider coming to the United States
fellowship, I would suggest that you write
approximately nine months in advance, indicating the probable
date of inception and enclosing a copy of your curriculum vitae.

for

a research

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
8M: .

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                    <text>V

May

'{nw

.
1.“.

2. 1963

v-

Dr. Corneliu Giurgeo

Head

of the Pharmacological Department

Scientific Direction

pry-‘1”“Inn-mnv-W-HHWIHXWMW—

Pharmaceutical Division
68. Rue Berkendoel

Brussels 6, Belgium

ﬂrMW-irw-mr;

Dear Dr. Giurgea:

pleased to.hear your report at the CINPaand to
with you. I am enclosing a copy of two reviews
which recently were completed for the ACNP. They describe
I was

discuss

'.l’&gt;(

"3‘41'V2W’m"’m

it

the state of our knowledge and provide

optimism that these techniques
I am also enclosing a
methods in greater detail.

W'W'lv

”WV.

't.

may

be

me

with a basis for

useful.

reprint which describes our

“I

7

My
-mix—.,,-;n'7—

best regards.
Sincerely yours,

_

.i

m

"F'

Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

Vw&lt;vwsr77

7'

.
,

',

W-WTT/‘W'HEW'

&gt;

�</text>
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                    <text>.

“ﬂue...

“—r“

.
we

N.

.m

.
_.

v.9.vu-mm...

May

2, 1968

yum-www'

.
,
urns

r”

v‘lvaWWL-nrrn/"Wm

3'
~

qu‘l-wmw

wm.xrx-W-jx-ﬁzmm

Dr. A. Cerletti
Sandoz Ltd.
4000 Basle. Switzerland
Dear Dr.

Cerletti:

First, let me commend you on a remarkably fine program
CINP. It was a memorable meeting and my friends and
at
I found the scientific and the social programs most rewarding.
the

While we submitted a copy of this report for publication.
Dr. Polvan, 0r. Itil and I made a few corrections and added
more approoriate citations in the enclosed copy. Would you
please use this in the publication of the Proceedings and
discard the prior copy (No. 11)?
Thank you

zen-unvv—vv

-:

for your cooperation.

In,

Sincerely yours,
Fink. M.0.
Professor of Psychiatry

Mex

MF:kp

ac:

«

A

_

‘.,.

nvm-W.v-v»m~

v
n'lnvv

4v

m-‘w-a-w—c‘:

Dr. Polvan
Dr. Itil

�</text>
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                    <text>May

2, 1968

Dr. D. Tedeschi
Smith, Kline and French Laboratories
1500 Spring Garden Street

Philadelphia, Pennsylvania
Dear Dr. Tedeschi:

pleased to hear your report at the GIMP and to
discuss it with you. I am enclosing a copy of two reviews
which recently were completed for the ACNP. They describe
the state of our knowledge and provide me with a basis for
optimism that these techniques may be useful.
I was

also enclosing a reprint which describes our
in greater detail.

I am

methods

My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

enc .

�</text>
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                    <text>May

2. 1968

Hr. Lee Hanna

Director of

News

HCBS—TV

5l8 West 57th St.

New

York. New York l00l9

Dear Mr. Hanna:
He

would

appreciate

a

print of film

“:nti~na¥§otic” as prepared
0 “CBS”

by Mr. Earl

labeled
Ubill and the staff
Ho. 24556.

0

We understand there will be a charge for this prid‘
and I am prepared to reimburse H085 as suggested in my
discussion with Mr. Earl Uboll's secretary, Miss Hockman.
He would be very grateful if this print could be made
available before May §, which would penoit us to use
in
a special lecture on May 10.

it

Thank you

for your assistance.
Sioceroly yours.
Fink, ”.0.
Professor of Psychiatry

Max

MF:kp

cc: Mr. Uboll

�</text>
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                    <text>May

2, 1968

Dr. Charles Shagass

Department of Psychiatny

Temple University

Philadelphia, Pennsylvania
Dear Charles,
would you please send me a copy of your
the effects of drugs on evoked potentials?
Many

ACNP

review of

thanks!
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>May

2, 1968

Dr. Joseph 6. Bird

Director. Experimental Medicine

Sterling«winthrop Research Institute
Rensselaer. New York l2l44
Dear Joe.
Thank you very much for your letter of April 25. The
9rant~in-aid in the amount of $400.60 will permit us to send
Dr. Simeon to the meeting of the American Therapeutic Society.
if you could request a check payable
It would be least involved
Simeon.
directly to Dr. Jovan
We

have completed the data requested by you

for the

FEA

in the depression study and are

the oyclazocine patients
in the process of completing the narcotic addiction group.
Both should be available within the next fortnight.
on

Thank you

for your assistance.
Sincerely yours,
Max

Fink, H.D.

Profesnor of Psychiatry

Mszp

�</text>
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                    <text>ﬂay 2, 1968
Dr. Roger E. Meyer

Acting Chief
Center for Studies of Narcotic
and Drug Abuse

Rational Institute of Mental Health

5454 Wisconsin Avenue
Chevy Chase. Maryland 20203
Dear Dr. Meyer:

for your letter of April 22, and for your
we apply through the grant mechanism for
that
suggestion
funds for our marijuana research.
Thank you

I have received IND 4724 from the FDA and have written
Commissioner Giordano for a supply of marijuana leaf. A copy
of my letter to Dr. John Scigliano is enclosed.

Thank you

for your assistance.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Nax

Mszp

�</text>
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                    <text>May

2.

1968

Dr. John Scigliaoo

Center for Studies of Rarcotic
and Drug Abuse

ﬂationai Institute of Naotai Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

Dear 0r. Scigliano:
For many months I have been making the arrangemants

necessary to undertake naurophysioiogicai studies of marijuana
and its extracts. Before receiving the iotter from Dr. Mayer.
indicating that the supplies of these drugs can be obtained
from your office. I had uwitten to Commissioner Giordano for
the mariauana leaf.
we are equipped to undertake some preiiminary studies
of THC and wouid iike to make such axpiorations. At your
convenience. may we request 250 mg of THC for this initial

triai.

Thank you

for your cooperation.
Sincaraiy yours.
ﬂax Fink.

".8.

Professor of Psychiatry

Mszp
cc:

Or. Mayer

�</text>
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                    <text>May

2, 1968

Dr. Richard P. White

Associate Professor of Pharmacology
Department of Pharmacology
The University of Tennessee

Memphis, Tennessee 38l03
Dear Dick,

It

was good

to hear

study is going well.

from you and I

am

pleased that the

This study program is supported by MH-12567 (Pharmacotherapy
of Narcotic Addiction) and by funds of the New York State Narcotic

Control Commission.

enclosing copies of all the reports which may be
may be found at the end of
the naloxone study.
I am

relevant. Additional citations

While I can sympathize with your need to obtain more data,
perhaps I can make some contribution if a preliminary draft were
made available before the June meeting. At least would you call
me at your convenience and perhaps we can discuss your
progress

in that fashion?
My

best regards.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp
ENC.

�</text>
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                    <text>May

2, l968

Dr. James Bailey

Foundations Fund for Research

in Psychiatry

100 York
New

Street

Haven, Connecticut

Dear Dr. Bailey:
During the past two years I have participated in a collaborative
study program with the University of Istanbul in the evaluation of
new psychotropic drugs in the treatment 0f the mentally ill. Our
initial results have been encouraging and we would like to expand
these studies since they provide opportunities to test hypotheses
which may not be practicable in the United States. For example.
we have Just completed a high dose and very high dose fluphenazine
study, to test the recommendations of some French scientists.

In discussing our program with Dr. Jonathan 0. Cole, formerly
of the Psychopharmacology Research Branch of NIMH, he suggested
that I write to you to inquire whether the Foundations Fund might
consider an application on behalf of such a study program.
such a program would include
Director
of
the Division of Psychopharmacology.
Itil,
Missouri Institute of Psychiatry (St. Louis) and Professor Necmettin
Polvan, Chairman of the Department of Neuroosychiatry, University of
The

principal investigators in

Professor Turan

M.

Istanbul.

Thank you

for your interest.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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l,

l968

Dr. Leon Wurmser, Director

Psychiatric Outpatient Department

Sinai Hospital of Baltimore, Inc.
Belvedere Avenue

at Greenspring

Baltimore, Maryland 212l5
Dear Dr. Wormser:

Enclosed is a copy of our report which has Just been
accepted for publication.
I

trust it is helpful.
Sincerely yours,
Max

Fink, M.D.

Proféssor of Psychiatry

Mszp

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                    <text>May

1, 1968

Dr. Leon Hurmser. Director

Psychiatric Outpatient Department
Sinai Hospital of Baitimore. Inc.

Be1vedere Avenue at Greenspring
Ba1timore. Maryiand 21215
Dear Dr. Hurmser:
Enc1osod

is

a copy of our

accepted for publication.
I

trust

it

report

which has

just

is heipfu1.
Sincere1y yours.

Fink, M.D.
Profcssor of Psychiatry

Max

MF:kp

been

�</text>
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                    <text>.
u

W.~q,..—A~qw~w—v:.ws-.w-

wwﬁr‘h-nmvzl-t

w-

May

l.

1968

Editor

Lancet

Editorial Office
7 Adam Street

Adelphi, London, H.C.2
England

Gentlemen:
The

recent annotations 'Addiction

little

New

Style'

and 'Drug

reference to the use of
narcotic antagonists in the treatment of opiate dependence.
As alternate pharmacological models to methadone, clinical
trials have been undertaken with a long-acting narcotic
antagonist, cyclazocinel‘8 and more recently. naloxone.°‘13
These compounds provide engagement to the treatment program
not based on legal restraint or drug dependence ubiqﬂlgggyidggﬂwnmwm, agent.
an opportunity for habilitation and education so essential to
the addict's integration into the community.
Dependence:

A

Symptom' make

British arrangements for treatment of addicts
emulate
the unsatisfactory American experiences.
to
appears
We would commend these models to your attention for further
study in the new centers.
The new

Sincerely yours,
Fink. M.a.
Professor of Psychiatry

Max

Alfred M. Freedman, M.D.
Professor of Psychiatry and
Chairman of the Department
MF:kp

�</text>
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                    <text>April 30, 1968
Dr. Morris 8. Bender

East Shore
Kings

Road

Point,

New York

ll024

Dear Morris,

It

was a great pleasure to read the announcement of your
I know that your many students will be as
new appointment.
I
that
as
recognition came to you in the form that
gratified
did ~ a rostrum from which you can lead many other young

it

students into neurology and research.

Congratulations and my best wishes for success of your
Department and the New Mt. Sinai School of Medicine. Please
also extend my regards to Sarah.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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n.

April 30, 1968
Dr. Robert
‘

Jaffe

t of Neurology

Sinai School of Medicine

Mount

Fifth Avenue and 100th Street

New

York,

New

York 10029

Dear Bob,

for

Enclosed

is a

check

Dr. Bender on Hay 8.

for my subscription to the dinner
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

M‘szp

�</text>
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Dr. George M. Simpson
Rockland State Hospital
Ormgebm'g, New York 10962
Dear George,
Our data on the laboratory changes was published in the
05 Clinical Phwmacotagy and I am pleased to enclose

Jamal

a reprint.

I believe it is important that each laboratory study
patients on placebo medication at the same time as active
drugs in order to provide accurate ooncm'rent estimates of
the usual laboratory ranges. "Concurrent" is the important
term, since seasonal changes and changes in technicians,
m-agents and equipmnt cannot be predicted frun sequential
studies.
Itwas nice seeing

you

in Spain.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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E

u-q-‘n! ‘.

-

~

.,n

't'gr'

,

:.‘

“Km; Ham» .1u'»;"lV".V»'Z"
.

-

..

v.. ‘.._V,,“....\ m
,

.

.

m..- u m1:
$k. :1 , ,...;

.

r.»

a ,‘-.4
.

«.—

o... w- \' a.w.,.__ --.v« ,

April 30,
Mrs. A. L.

.m.

w.

W'W-W‘"-

v:

”«rvv

1968

szado

Metropolitan Hospital
Pharmacy
1901 First Avenue
New York, New York

5

E

Dear Mrs. Crusade:

E

E

Enclosed are two notes which I have received in the
last few days regarding problems in the prescription of
drugs fmn the pharmacy. I would be grateful to have you
check these.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mf‘ﬂcp

�</text>
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                    <text>April
Dr. Robert

30 , 1963

Jaffe

t of Nemlogy

Pbtmt Sinai School of Mid!»
Fifth Avenue and 100th Street
New York, New York 10029

Dearaob,

Enclosedisacmckfwmysubscriptiontotmdimm

forbr. Benderonﬁaya.

Sincerely yams ,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

�</text>
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                    <text>.
-

x

“an.“

”M

-,.-

April 30,

1968

Dr. William Tabor

A. H. Robins Company
1W7 Cmnninge Drive

Mahmud, Virginia

DearBill,
Wehave

meeivedﬂnesupplyofbutapemzineplaceboand
p'Ihestudy

ﬂareportfom. Wyouverymchforboth.

isgoingvery wellmdwearebegirmingﬂxesmmryofour

initial data.

This

will be available in the next

two

Sincerely yours ,
Fink, PM).
Professor of Paydziatry

Max

MF:kp

maths.

�</text>
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                    <text>April

30 , 1968

Dr. George M. Simpsm
Roddand State Hospital
Omngeburg, New York 10962
Dear George,

Ourdataonthe labomtozycmngeswaspublismdintm
mum thcatogy and I am pleased to enclose

Joanna 05
a reprint.

I believe it is important that each laboratory study
patients on placebo medication at the same time as active

some

drugs in order to provide
omcmment estimates of
the usual laboratory ranges. "Concurrent" is the importmt
term, since seasonal changes and chmgss in technicians,
m—agents and equipment cannot be predicted from sequential

studies.

It was nice seeing you in Spain.
Sincerely yoLIrs,
Mm:

Fink,

11.1).

Professor of Psychiatry

MP:kp

�</text>
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                    <text>April 30, 1968
Mr. Henry L. Giordono

633 Indiana

NM.
AW,20226

Washington, 13.0.

Dear Mr. Giordono:
we

rvv-

&lt;

ru

:
vngr'

w»

_

In addition to our ongoing studies of narcotic addiction,
to undertake studios of marijuana and

have been omomaged

marijuanaextmota. Aoopyofapmtoool forauohastudy,
approved by the oomittoes of this College, is enclosed.
We

rave received a Special

m Stanp, Class 5

-—

marijuana,

also have filed INDH'IZH with the Food and Drug
Aministratim, DEW. A copy of the IND letter from Dr. Gibson
is enclosed as well.
No. 127-11; and

I am writing to request the Bureau make available for our
experimental use approximately one pound of mfinod or high
gmde marijuana.
Thank you very much

for yum cooperation.
Sincerely yours ,
Pink, H.D.
Professor of Psychiatry

Max

�</text>
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                    <text>April 30.

1968

Dr. Halter Modell, Editor
Clinical Phanmacology and Therapeutics
Cornell University Medical College
l300 York Avenue
New York, ﬂew York lOOZl
Dear Dr. Hodell:

is a revised copy of our report “Behavioral and
Naloxone in Heroin Dependence.“ The suggestions
of
Studies
and criticisms of the editors were very helpful and we have
considered these comments and included our responses in this
Enclosed

EEG

presentation.

items were not incorporated. The question as to expenae
of naloxone is unanswerable, since Endo Laboratories has consistently
Two

refused to provide a price.

They have indicated

that

stated that
expensive for
naloxone from overseas sources and in this way make
them. and have

it was

too

they might try to obtain

for future research.

it available

other reviewer asked whether the development of physical
dependence on cyclazocine served a useful purpose in discouraging
patients from deliberately missing doses of that drug. he also
asked what is to prevent patients on chronic naloxone from omitting
Your

doses during periods when they plan to use heroin. Physical dependence
to cyclazocine is minimal since the sudden cessation of treatment
results in a withdrawal syndrome of a grippe-like nature. This is
easily tolerated by patients. 80th the cyclazocine and naloxone
subjects omit doses during periods when they plan to use heroin,
but they learn to take their cyclazocine or naloxone soon thereafter
and

this

maneuver seems

to

keep them from becoming readdicted.

lead summary is provided. as suggested. Thank you very
for your cooperation.

A

much

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC .

�</text>
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