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                    <text>1
v.

-_x-

v

lwyﬁi-V'miw‘h

u-w

vprrw

J-WWWI‘WK'IW‘I‘H

March

25, 1969

Spitzer
Psychiatric Institute
West l68th Street

Dr. Robert L.

The

722
New

York,

Dear Dr.
I am

failed

New

York

Spitzer:

terribly embarrassed that

my

accounting system

me, but during the past few days my secretary
reminded me that we had not obtained the enclosed checks
soon after you lectured here. Please accept these honorariums
on behalf of your participation in our programs and for
the assistance you have given Stanley Feldstein.
My

best regards.

I

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>'w"fhmﬂr

“(Ivar-V

"VLW

—-—,—

mu
..
.A.

'lmﬁmr'wm

um-

m.

March

25,

1969

Dr. Burtrum Schiele

Department of Psychiatry
University of Minnesota
Minneapolis. Minnesota
Dear Burt:

is a draft cony of our report as submitted to
Phanmacology and Thenapeuxicb.

Enclosed

Clinicat

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

'rw:

‘r-W'W'Ir"ya

�</text>
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                    <text>Fr“ wmpvn—u, VwV—w.m—.qymmmm

~-,w—-v—x-w.

w—w».

.n m

wmmmm-

'

~

-

--

-~

e-

W.“ﬂ’ir'vz’vw—"F"('w=~wnwﬂwﬁ‘v~mﬂw'v—

.

March 26, 1969

i

Dr. Maxwell Gordon
Smith Kline a French Laboratories
1500 Spring Garden Street

Philadelphia. Pennsylvania

19101

Dear Dr. Gordon:
L

3

5

3
E

pleased to enclose the most recent reports of EEG
of
measures
psychoactive drug effects. The data is still
I am

and we now have 3 new drug/EEG studies in progress,
one of which is in Phase I Study. He should have more
data by the year-end.

sparse,

Sincerely yours,

l

Fink, N.D.
Professor of Psychiatry

Max

;

w-a,—~yww

-u-r

.‘iFﬁcp

�</text>
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                    <text>.7

...

.,.....A,,‘.-_._.,,,_

A".-.

.i
.

~......

March 26, 1969

Dr. Milton Kletzkin
Department of Pharmacology

Wallace Laboratories
Cranbury, New Jersey
Dear

Milt.

I want to thank you for the opportunity to visit your
laboratories which are most impressive.
—

A

.,

"wt-r"

V”.

Sunday I met the Chairman of the 1970 CINP program
committee and discussed the interest in a program of animal
EEG models in psychoactive drug evaluation and classification.
The suggestion was well received, and I would like to discuss it
On

with the full committee

on May

6-7.

If you are interested in participating,.would you be able
to review the world scene and recommend scientists from industry
and the academic scene, who may be able to contribute?
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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              <elementText elementTextId="37842">
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                    <text>,_.u.

w‘ w‘

March

31,

1969

Dr. Jack Mendelsohn

Alcoholic Research Center
National Institutes of Mental Health
5454 wisconsin
Chevy Chase. Maryland

Dear Dr. Mendelsohn:

J. Miller, President of Killer Pharmacal Co..
visited our laboratories this week to discuss the possibility
of improving the dysfunction of chronic alcoholism by dietary
substances containing trace minerals.
Dr. John

A

your

copy of

files.

his interesting point of

View

is enclosed for

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

'

.

�</text>
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                <text>Correspondence to: Mendelson, Jack H.</text>
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              <elementText elementTextId="37828">
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              <elementText elementTextId="37831">
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            </elementTextContainer>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37832">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            <name>Source</name>
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              <elementText elementTextId="37833">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <name>Format</name>
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                <elementTextContainer>
                  <elementText elementTextId="102870">
                    <text>mevrn~

vvw-

unusu—

Marco 31. 1969
Mr. T. Bloomer~
.

“
i

“—1,

v

.7

"um“

v.1;

n

“gun.

.mv

‘q‘l-«Iw

IBM

‘

475 Northern Bivd.
Great Neck. New York

Dear Mr. Bioomer:

discussed with you on Tuesday, we have been dis»
amount of time that our IBM 1800 has been
vdown.
In comparison with our previous experience with IBM
equipment and in view of the reputation of this instrument,
I wouid appreciate your review of the stabiiity of our equipment
and the program for updating and the probiems in software
support.
As I

satisfied with the

Thank you

mumvrmr-

,qn.

for your cooperation.
Sincerely yours;

“ﬂu—r..-

ﬂax Fink, H.D.

Professor of Psychiatry

MF

:kp

�</text>
                  </elementText>
                </elementTextContainer>
              </element>
            </elementContainer>
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        </elementSetContainer>
      </file>
    </fileContainer>
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              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37817">
                <text>1969 </text>
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          <element elementId="39">
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              <elementText elementTextId="37818">
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          </element>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37819">
                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="37820">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37821">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37822">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37823">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="77984">
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              </elementText>
            </elementTextContainer>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="84545">
                <text>application/pdf</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="91106">
                <text/>
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          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
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  </item>
  <item itemId="3781" public="1" featured="0">
    <fileContainer>
      <file fileId="2243">
        <src>http://exhibits.library.stonybrook.edu/mfp/files/original/d6be09e3a1b0e9d9ea04d5acc9e5a3aa.pdf</src>
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            <description/>
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              <element elementId="52">
                <name>Text</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="102869">
                    <text>_..

m.“ ..

.

..

p,~

..

.4.

W.

._»

.«uptru’uJuN-Aiﬁpaan:" «(um 3‘

--

~
.

March

,

,

31,

.

~,

c.

.0“?

V

,,~3va »-v--

”v .vawwg

1969

Dr. Dean J. Clyde
Clyde Computing Service
Box 166, Coconut Grove
Miami, Florida 33133
Dear Sean,

It was a pleasure to talk about our common interests. I
discussed the laboratory data form, its output and statistics
with Don. He is still not ready to release the programs, since
they require documentation. He also are dissatisfied with the
format of our outputs, including the statistics and are continuing
to work on them. As soon as they fulfill our present expectations,
I would

like to send

for your critique.
service to industry is

you samples

Your idea of providing a
admirable one. Good luck!

.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

“7”,.

.
v;
A
m.

vwvnnmnrwpy—n,

WWI-mOm'lﬂz'rrrnw-qn

,,
&gt;4

"WV-(Wlwllﬂvfywwm

n'v’w'

14“-

MF:kp

an

.awwnm‘-

aw... I597:

�</text>
                  </elementText>
                </elementTextContainer>
              </element>
            </elementContainer>
          </elementSet>
        </elementSetContainer>
      </file>
    </fileContainer>
    <collection collectionId="1">
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Correspondence</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
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    <elementSetContainer>
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          <element elementId="50">
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                <text>Correspondence to: Clyde, Dean J.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37807">
                <text>1969 </text>
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          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37808">
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            </elementTextContainer>
          </element>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37809">
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              </elementText>
            </elementTextContainer>
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                    <text>April 1. 1969

Irs.

JoAnn Hammell
Women's Club
8632 East Keim Drive

Scottsdale Jr.

Scottsdale, Arizona

Dear Mrs. Hammellz»

In reply to your inquiry for information to support

your newly implemented "Dope Stop” program, I am pleased to
enclose reprints of some of our recent work. These will
indicate that a useful approach in the treatment of opiate
addiction is the pharmacological antagonist model.
luck in your new venture.

Good

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>V...

.,

W. 7..-..7 .wW—m.-v—- --*

rv1yw'IrwnwmnV w‘mvwwwrm

March

31.

1969

Dr. Allen E. Hussar

Chief, Medical Service and
Associate Chief of Staff for Research
Veterans Administration
Franklin Delano Roosevelt Hospital
Montrose,

New

York 10548

Dear Dr. Hussar:
Thank you for your suggestion of studies of dextroamphetamine
in schizophrenic patients, and the reprint of your work. The
suggestion is very good and should be followed.
Our own program of study is focussed on the effects of
drugs on the waking EEG. This permits me and my associates
to have a more "normal“ family life. There are many workers
interested in the effects of drugs on the sleep EEG and these
include Feinberg in New York, Kales at UCLA and Itil in

Missouri.

an ongoing

I am

sure there are others, but

file of sleep studies.

Thank you very much

I do

not keep

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>i

s
E

w'zwrﬁ‘w-v—v"

.-

y-u—‘W‘me

y

March 31. 1969

Dr. Jean Bobon

Clinique Psychiatrlque
Rue

Saint—Laurent. 58

Liege, Belgium

Dear Dr. Bobon:

w",

"m.

W7

I look forward to participating in the Interdisciplinary
I am writing to confirm my planned
Heek on Neuroleptics at Liege.
at l435, SH 794.
arrival in Brussels on Sunday, May

ll,

I look forward

37...”...

to the meeting.

mm”

Sincerely yours,
Fink. M.D.
Professor of PsyCh‘atry

_Max

Hszp

�</text>
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                    <text>IMARCH

31, 1969

VEDA ELECTRONICS
2115 DE LA CRUZ BOULEVARD
SANTA CLARA 95050
GENTLEMEN:

NE NOULD APPRECIATE RECEIVING A CATALOG OF THE
PRODUCTS WHICH PERMIT THE REMOTE CONTROL OF TAPE RECORDER EQUIPMENT,
As MAY BE USED IN RECORDING PSYCHIATRIC-INTERACTIONS. NE ARE INTERESTED
IN THE APPLICATIONS SEEN AT THE LANGLEY PORTER CLINIC, IN THE RECORDING

OF NURSING~PATIENT DISCUSSIONS.
THANK YOU.

SINCERELY YOURS,

MAX
'

MF/

FINK, M.D.

PROFESSOR OF PSYCHIATRY

�</text>
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                    <text>March 31. 1969
Dr. Tatum E. 1:11
5600 Araanal Street

It.

Lapin, Missouri

Bear Turtn,
Some weeks ago, w1111a3.2uag was in New York and
I issued 13:: year fer him to visit and review
an
invitation
accepted
our computer analytic programs at the alaepvxﬁs. He did so, by checking
the playback at one of ab: records we had analyzed using the pregram
from St. Louis. modified for the IBM 1800 and with the Klinganbarg

revised standards.

‘

His summary is submitted as three figures and
copien of which at: unclosed.
Agreement

in stages a,

a matknd discrepancy in stage:

C

A, and

and E.

D

tablet.

1. good; but there is

Please review those figures and on your next trip East,
can go over tho original data as Bill lung did and assess
perhaps
the bases for the differences in the classifications.
we

Hy

best regards.
sincoraly yours,
Max

cc: Bill lung

Fink, M.D.

�</text>
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                    <text>April 1,

1969

Dr. Ellsworth Cook

ASPET

Bethesda. Maryland
Dear Dr. Cook,

I have read your announcumant at a wbrkahop on Principles
of Drug Evaluation in Man, scheduled for Jun: I~13. I have been
interested in the problem for many years, and have focussed on the
use of electrophyniologta tachniquea in studio: of new drugs in man.
If at :11 practicable, I vauld lika to participata in this workshop;
and am writing to raquest ppplication forms and ptogram.
Thank you.

Sincerely yours,

ﬂax Fink, K.D.

Profasaor of Paychiatry
mf/

�</text>
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              <elementText elementTextId="37752">
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                  <elementText elementTextId="102862">
                    <text>W‘W'w :amuu-r...

:rua—‘amwi-‘w—

.
‘n‘r‘s,, V'v;~5~KVF-:"’k~vrv'~'

WV
,

um,
,

..

,

, m—
I~
.

,

-

i

(m’wm-slvw‘v.
,

m-

.7

*‘v;

,

,,

m"

W"

new.-

n

“A

"Faun.“

'1!va

—

April 1. 1969

E

E

1

E

;

E

Elsevier Publishing

Company

P. 0. Box 211
Jan van Galenstraat 335
Amsterdam, The Netherlands
Gentlemen:

s

E

are sending you a purchase order for a
EEG Journal for 1969.
We are interested
in obtaining issues of previous years for our laboratory.
Will you please advise us as to which years are still available
and at what cost?
Separately

we

subscription to the

E

g

;

Sincerely yours,

;

Mex

Fink, m.o.
Professor of Psychiatry

g

E

E

g
E

i
E,

,&lt;nw-ww&lt;:

War-'1‘.

wax

.w

r.

*‘Nzwn‘rwr

rm

mu-

“(Iran

in
“N'—

"

:.v-—w—v~,mwrrmw~wmr1ww

74'“

unwary-m

MF:kp

.murwn—sxra-v—vvy

'w-V

W'nw'r :WL

�</text>
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war—”v:

v“

v»

—-—v-.—

April 1. 1969

8. Squire
Administrator
Forest Hospital

Mr. Morris

555 Wilson Lane
Des Plaines. Illinois 60016

Dear

ﬁr. Squire:

With regard to your inquiry regarding my participation in
the ”Search For Mental Health" I regret that I will not be at
the APA this year. I will. however. be at the meetings for the
Society of Biological Psychiatry and could make time available
on Saturday, May 3. I will be staying at the Hilton Plaza.

Sincerely yours,

-—;—v-m.-.~rwr-u~r;vv~ww

.--—-w

Fink, M.D.
Professor of Psychiatry

Max

Wm

W

MF:kp

�</text>
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                    <text>.

' w. ' -.s*"

w wwazxr

WW

,~

nun-4

-~

w .vr— -~w

. m «or,m

swamW.wlva slun-

w

uran- nmv :ux;

-~

w-wn-wam-wauu- .m w '

m w «an YJW-w-www“w

w:- "van-Art‘mwtqn‘nvs'mnwz

A

VA

c.

V

.
.
A

A

.AV

A

A,

,
A.

.

.
.

w

.v

_.

...,.,~

..

April 1, 1969

'a—unwnv&lt;v.rnn'.v&lt;u"

,
.v

,.,,,V,,,,.....vwn..w.—

Hrs. JoAnn Hammell

Scottsdale Jr.

Women's Club

8632 East Keim Drive

Scottsdale, Arizona

Dear Hrs . Howell:

In reply to your inquiry for information to support
your newly implemented "Dope Stop" program, I am pleased to
enclose reprints of some of our recent work. These will
indicate that a useful approach in the treatment of opiate
addiction is the pharmacological antagonist model. Good
luck in your new venture.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 1,1969
Hr. Morris B. Square

Administrator
Forest Hospital

555 Wilson Lane
Des

Plaines, Illinois

60016

Dear Mr. Squire:
With regard to your inquiry regarding my participation in
the PSearch For Mental Health" I regret that I~will not be at
the APA this year. I will, however, be at the meetings for the
Society of Biological Psychiatry and could make time available
on Saturday. May 3. I will be staying at the Hilton Plaza.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

4

'-7

4

HF:kp

«.7

.
\JH‘“

�</text>
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                    <text>“v."

.

W":

,

1“—

April 2.

1969

Miss Carol Lindeman

Albert Einstein College of Medicine
Yeshiva University

Road and Morris Park Ave.
York 10461

Eastchestar

Bronx,

New

Dear Miss Lindeman:

Dr. Abrams and Dr. Dornbush were kind enough to bring

Some years ago
this interesting protocol to my attention. which
we compared
I was involved in a similar undertaking in
A
Indoklon.
and
means
and
electrical
convulsive therapy
capy of that report is enclosed for your information.

Good luck

in your studies.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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1969

Mr. Arnold Canter
P. 0. Box 325
Purchase, New York

Dear Arnold,
In the previous quarter and in this quarter we have
completed this form as enclosed. I believe we are interpreting
the law correctly, but I need your assurance.

Is

this correct?
Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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‘

~'

V‘

"h“*?"'--w~'wwm-r xv- “w nmw ”(Hyman-owlﬂw

vnﬁm-w...‘m.. WW.
«

»

-

1

-

7-. «&lt;—
-

~
-- K'u‘
7—-m

‘--' ..~.~a~.-~.,.,A.~.._;

W.“ vow—”(9..."5

April 2. 1969
Miss Carol Lindeman

Albert Einstein College of Medicine
Yeshiva University
Eastchester Road and Morris Park Ave.
Bronx,

New

York 10461

Dear Miss Lindeman:
Dr. Abrams and Dr. ﬂornbush were kind enough to bring
Some years ago
this interesting protocol to my attention. which
we compared
in
I was involved in a similar unnertaking
A
Indoklon.
and
convulsive therapy and electrical means
information.
copy of that report is enclosed for your
ﬂood luck

in your studies.
Sincerely yours,
Fink. £4.13.
Professor of Psychiatry

Max

Mszp

”n...“

4"

m,

L.

l
V

-u-vﬂv.

..
..‘

&lt;..,._,_

l.

m.

I».

'In-"mvjn’wv:

=-:y

�</text>
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                    <text>‘--

WK -~-rv*m-

r u-‘w-‘o-w

nm-wu—warwm. '&gt;ZW'-rmﬁ‘wwnxe-y\.wnv

w

..

.m—w

.rmmvvw: ‘Iarw-swwnlvah-v" w ,«v..m——,..w.....m.

April 2.

or.

.

.1:

....,,...,

..,..\

- , aw..." i......,‘-

1969

Z. Votava

Institute of

Pharmacology
Medical Faculty of Hygiene

Charles University
Praha 10 ~ Vinohrady.
Srobarovo 50, Czechoslovakia
Dear Dr. Votavo:
Thank you very much for your kind invitation to participate
in the Program Committoo meetings on May 6 and 7. in Prague.
I am pleased to accept your invitation and plan to arrive
directly from new York on Monday, Hay 5, from Frankfurt on
196. This is scheduled to arrive in Prague at
tgfgansa
: 0 am.

to working with you
extend kindest greetings from Professor
I look forward

who

are

now

in

new York.

and I oodso pleased to
Roubicok and Dr. Volavka

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

m.-

v.

vn

MF:kp

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Passport Office

U. S.

630 5th Avenue (50th
New York, New York

&amp;

515t

Sts.)

Gentlemen:

bearer, Ira Snapper, is authorized to request
validation of passport #6177566, MaximiIian Fink, M.D..
i request revaiidation to fac111tate a visit to Prague
The

n May.

Sincere1y yours,
Maximiiian Fink, M.D.
Professor of Psychiatry
MF:kp

�</text>
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                    <text>n,»

«r

m.”

-

ngvr—

Aprll 3,

«m—

'r

2969

1—"

...&lt;.

.rv—w.

Dr. Norman Pitts
Chas. Pfizer &amp; Co.
Grotan Connecticut
Dear Norman.

Please send

parenteral

me

Doxepin

an additional 15 ampules of 2

to continue our

EEG

studies.

mg

Thank you!

Sincerely yours.
Fink. %.0.
Professor of Psychiatry

Max

MF:kp

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                    <text>April 3.

1969

Dr. Isadore Samuel Zfass
Chairman, Commercial Exhibits
2502 Monument Avenue
Richmond, Vigginie

Isadore,

Dear

Surely. the computer representatives should be
I would suggest Bigital Equipment Corporation.
make the PDP series of computers, Scientific Data Systems
may be interested in getting into this field, and 13%.

represented.

who
who

It

may

be too

late for

many

of these companies. but

perhaps something can be done by phone.

the

My
DEC

interaction has been with IBM only and I do not know
or $85 representatives. Since both instruments are

probably represented

at the Brain Research Institute, perhaps

a member of the organization committee could make the initial
representation. I will be glad to call IBMVand make inquiries

here.

availability of the exhibit hall
at the earliest, I am concerned that this
will make the demonstration very difficult. I will inquire
of IBM as to the feasibility of this schedule and let you know.
with regard to the

on September 12

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>vApril
Dear

A, 1969

Fritz,

To confirm the sense of our didcnee sue yesterday, I an
taking the liberty of expending the suggestion: ».de for the 1970

progren.~

‘

of unilateral ea“ bilateral electrode place“
may seem to .e a trivial change in the
treatment procedure, but the data are .eet intereeting. The clinical
results for either placement are not similar. but behavioral change
is accoupenied by defined differen» a in memory functions and in
6N8 effects. The oheervatiene eve useful in understanding the relationships between memory function :od outcome; between Chg effect: and memory;
and in supporting theories 0 =he node of action 0f induced convulsions
described more than a deceo ago.

ment

The problem

for convulsive therapy

deny yonng contributors to the field, including
(HY), Blathly (Oregon), White (Ky), Keelhling
(HY)‘ as well as a fine group in the United Kingdom.

There ere
Snell (Indiana), Abra“.
(Ohio), Strain

A
ogrnn dedicated to the contributions of these
authors, with e' interpretation of the observations for our understanding
of the convul. ve therapy process and the treatment of affective
be consistent with the aims of the 1970 meeting. The time
disorders,
such
a review may he at least 4 hours, and perhaps, if
neceeeary :.r
some Engl ~h authors are induced to come. even longer. Such an allocation
of time ran the regular program may be unjustified, and perhaps a useful
solut . may he the holding of a concurrent tension either on the Thursday.
befov: or the Sunday after the APPA.
p

w

,

i

The financial arrangements for these speakers and the
additional expeneee of hotel end publication may be defrayed by Federal
or private granting authorities, since the subject has not yet been
covered in any national meeting. I have an HIKE contract for the

�4

'

..r.-v-.ar.m~&gt;a_w

w.

”ﬁx

4R

~2-

Freyhan

April 4,

1969

.

,

m,

.

,
_

.ww’vrnurﬂﬁn...

evaluation of unilateral and mnltﬁilo monitored ECT, and I believo
that the agency directors would be sympathetic with such a suggestion.
with the

New

With regard to the hotel arrangements, I am proceeding
York Hilton and plan to go there this week.
my

best regards.
Sincerely yours.
Max

Fink,

M.D.

�</text>
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                    <text>April 5,

~
._

wwgmwl.‘

ﬂaw-r”

)Qﬁdmrrrm

WJW'TfZwnr,'-&gt;r.’v'.'|fy‘.-7F~,~r

I;
F.

E

E

g
E‘

F

g

i
i
E
E

E

3
5;

1969

Dear Leo,

I have just read your review of the clinical status of
psychotherapeutic drugs in Clinical Pharmncolqu and Tﬂerapeutiua with
great interest and wish to congratulate you on writing an aminently
readabla and useful report. I would apptactate a reprint whan thesa
are available, but will probably gore: the report for the students, since
most of the opiniona are similar to thase which I hava preaaated and
hold.
Taste nra a few cmmmenta that I.would like to ahara
with you. Recently, with regard to the'anti~anxiety druga, um
reviewnd our clinical recordﬁ and found that tha results observed
for chlozdinzapoxide were vary gaod during the early waaks of treatment,
but the response became prograasively less in time. we examined the
data for the possible development of tolerance ané in some reeant cases
we have athieved better results by interrupting treatment at frequent
intervals. In our studiaa of high acne tybamate in tha treatment of
opiate addiction, we were aatonlshed at the rapid rate which the
patients dgveloped tolerance to the aeprasaﬁve an&lt;§sedat1ng effects
of the dosages we uaad ( ti 12 Gms.

)

In the notes on tha traatment of psychosis, why was no
mention made of the possibla utility of long~acc1ng fluphanazine ?
Your choice of thiariduaina as can of the drugs to be
included in one' a armamentariua shows how brave ycu reall.y are, for the
EKG changes which vs found so prominant have haen sufficient t0 deter
me from racommending it for just each purposes.

Again,

my

congratulations on a reviaw well dona.
Sincerely yours,
Max

Fink,

M.D

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                    <text>April 7, 1969
Dr. Philip A. Boyer
Marion Laboratories
10236 Bunker R d
a
Kansas City. Misgguriag4137
Dear Dr. Boyer:
I have received the supplies of pyrovalerone and our
trials will begin this week.
As

illness.

initial

subjects will be volunteers without mental
following records are obtained for each subject:

you know. the
The

Summary

psychiatric evaluation. social data

Permit for investigational drug use
Clyde Mood Scale (before and at fixed intervals after drug)
NYMC symptom check list (usually changed for definitive
EEG

experiment)

summary, based on

visual

and

quantitative analyses

pilot study. these data do not necessarily follow a systematic
collection schema. since we are exploring the appropriate times and
dosages for the CNS effects. Nevertheless. the data is available. in
whole or in part. for submission to the FDA. It has been my custom
to invite the monitor to review the data before it is simply duplicated
During a

and shipped.

recent discussion with Dr. Jonathan Cole. now the
Superintendent of Boston State Hospital, he expressed an interest
in studies of vasodilators in the mentally ill aged. eSpecially
In a

wry-«m-

7.:
“n

those with organic mental syndromes. I recollect that you expressed
a similar interest. May I suggest you call Dr. Cole and discuss it
with him. if you are still interested.

i

I

_«

trust that

X

will

have some data within the next 8 weeks.

Sincerely yours.

pvt-«wavy:

an?"

&gt;

'42qu

--

Fink, M.D.
Professor of Psychiatry

Max

pr'ﬂﬁﬁ

MF:kp

�</text>
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                    <text>Aprii 9. 1969
Dr. N. Bohanek.President
Dr. M. Mihovilovic, Secretary

Zagreb. Yugosiavia

Dear Dr. Mihoviiovic,
I regret that I Hi]! not be abie to participate
in the Second Yugoslav Psychopharmacaiogicai Sympasium. ihe program
is quite interesting and i know that I Hi?! be missing much of

interest.

Hay I

trcubie

Thank you
a successful symposium.

you

ta return the registration fee

for your assistance,

and

my

7

best wishes for

Sihcereiy yours.

Fink. M.D.
Professor of Psychiatry

Max

mf/
"
7"

'

"~'

'

w"mmzm‘*'='""v“-""

PW

�</text>
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                    <text>April 10.
Dr. Reginald

a. Eickfnrd

University of California.

1969

San Bingo.

School of undicino
oopartment of neurosciences

La

Jolla. California

92037

Dear Reg.

ﬂesnite much effort on my part. we have been unable to
provide the support noccssary for the exhibition in San Diego.
I regret that we will not be able to demonstrate our EEG

analytic

programs

for psychonhnrmacology.

I

trust this will

not affect the other demonstrations on the 1800. However, since
the New York office of 18M and our sales representative
(Dr. Wayne Jostrand) is making the arrangements for tho equip~
went. I would ask that you advise him of the development.
The

list

of demonstrations is

an impressive one and I

look forward to attending the Congress.

Incidentally.

my

best wishes

on your new

apptintnent.

Sincerely yours.
Fink. M.B.
Professor of Psychiatry

Max

nmp
cc:

ﬁr. Ernst Rodin

�</text>
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                  <elementText elementTextId="102847">
                    <text>....

mam”...

...

7.....mn

,

..

.4. ..

i. .7 h
.

.

w

a

._

w (II—w-‘wm‘ . mum
.

‘.

hwy. 7“,... ”wwwluvvq.“

a? ”awrm

, Pm _

v.

‘3 ..,. - ,

..

...,. w

V

,

-.

”4...._,‘-MM,,

April 10, 1969
m...”

.‘

”mp-Wammny'.

.n,

”v.2

,r

r
a

«.ww-~.&lt;.v—mw~n—..-..Vﬂ

or

Mr

q."

1.

-m-wmv-wwn;-~nvrmww~

Dr. E. G.

Caille

Maitre de Recherches
du Service de Santa des Armees
Chef du Centre d'Etudes et de Recherche:
du Service de Psychologie Appliquae
de

la

Marine

Araenal

Dear Dr.

~

Toulon, France

Caille:

Thank you

for your letter of April 4. addressed to

Drs. Shapiro, Ruchkin and myself.

Dr. Shapiro and I are pleased to accept your invitation
and will make arrangements to participate during the week of
June 15-21. 1969, in Toulon. I would appreciate any information
regarding accommodations. It is probable that we will be arriving
in Toulon on June 15 from Paris.
While Dr. Ruchkin is a member of this Department. his
program is part of a different division and he will write
to you rcgarding his participation separately.
I look forward

my

to meeting

you in Toulon.

My

best regards.

Sincerely yours.

“(-71"

Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>m‘ma‘TW-nrwow +r~w

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April 10. 1969

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Dr. Norman

Pitts

Chas. Pfizer 8 Co.
Groton. Connecticut
Dear Dr.

Pitts:
called to see

a patient who had obtained
from
a suppIy of doxepin
a “friend“ and had taken, at a
maximum 50 tablets. She recovered, but I feel that a summary
of this experience shouid be made a matter of your records.
In January we

Sincere1y yours.

.

,

w

“

'9‘V..u-:

Fink, M.D.
Professor of Psychiatry

Max
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                    <text>April 10. 1969

Sr. Philip A. Boyer
Marion Laboratories

10236 Bunker Ridge Road

Kansas

City. Missouri

64137

Hear Dr. Boyer:

In checking the supply of pyrovalerone, I do not
find any ”placebo“ tablets. Even in the pilot study
it would be useful to have 20 placebo tablets each for

the

tablets of pyrovalerone.

40 and 20 mg

Thank you.
5

Sincerely yours.
Fink. M.D.
Professorcf Psychiatry

Max

MF:kp

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                    <text>April 11, 1969
Dr. Marshall Gates
Department of Chemistry
The University of Rochester
College of Arts and Science
River Campus Station

Rochester,

New

York 14627

Dear Dr. Gates:
In checking through my files I find a letter of one year
ago regarding your work with the trans isomer of cyclorphan.

still

interested in undertaking clinical studies with
narcotic antagonists and I am writing to inquire whetner the
animal screening has-come along sufficiently to permit such
trials in the near future.

.Ne

are

Good

luck in your studies.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>April 11,
Dr. Gert

1969

J. Schulier

Assistant Ciinica] Research Director
The Squibb Institute for Medical Research
New

Brunswick, new Jersey 08903

Dear Dr. SchuIIer:

manuscript has been submitted to Dr. AIain Sanseigne
of Squibb International to be published as part of a volume
commemorating the meeting in Sitges. I have no other information
at the present time.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

A

M,

a.“

o
—

.:
.w
..
.
‘

'"W'"I&amp;'W""nr‘u

�</text>
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                    <text>.—

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April 11.
Dr. Philip A. Boyer,

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1969

Jr.

Medical Birector
Marion Laboratories. Inc.
10236 Bunker Ridge Road
Kansas City, Missouri 64137
Dear Dr. Boyer:
Thank you for your letter of April 8, inviting me to
you at the APA. I regret that I will not be attending
the APA meetings since I have a prior commitment outside the
country. I will be at the Society for Biological Psychiatry
meetings and will be pleased to meet with you on Saturday.
I will be at the Hilton Plaza Hotel.

visit

v.

.
V.

.
,

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.,—.

a
A

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We have begun our open EEG study this week and we hope to
have some data by the end of the month.

”nu—m.

Sincerely yours.

..

“.1,"

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Rn" wwuvr- '7‘

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,

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,

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April 16, 1969
Dr. Kenneth Lifshitz
Rockiand State Hospitai
Orangeburg. New York 10962
‘vr

to".

17..

Dear Ken.
Thank you

"“1WW-vﬂmrvmwwrwvyn

for your inquiry regarding our paper for

the Society of Biologicai Psychiatry. I had hoped to
present some information from our peotothai data but these
analyses have been more protracted than anticipated. Last
month I withdrew the report.

-v;—.v-v

A

soon as our present studies are compieted I
be glad to send you a copy.
As

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

nil]

�</text>
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                    <text>April 16. 1969
Dr. William Tabor

A. H. Robins and Compamy
1407 Cummings Road

Richmond. Virginia
Dear

Bill,
I look forward

to having

Would you meet me

floor at 10:00

a.m2

you

visit

on Wednesday. April 30.

at Metropolitan Hospital

on

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

~
-

—

.

war-wuur

u-

W:w)nrp-*F'V.WY‘

the 15th

�</text>
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&lt;;&lt;;~j')‘vl-,‘

Mir-cur;

April 17.

m1.”

1,.

M17:

4'ﬂvrv;

‘ommmi‘

Mr.

J. h. Tielrooy

Elsevier Publishing

1969

Company

Jan van Galenstraat 335
P. 0. Box 211
Amsterdam, The Netherlands
Dear Mr. Tielroqy:

I am writing with regard to my subscription to the
Journal and your recent letter reminding me that my
subscription has run out. I have tried to arrange payment
through the New York Medical College and would like to tell
you that our records indicate payment send on March l
(check #29486) in the amount of $50.00. This check was to
cover subscriptions to the EEG Journal for me and Dr. Sidndy
Neinstein of the Department of Pediatrics of this College.
EEG

«V

me

If, for

and I

any reason this has not been
you a personal check.

will send

received. notify

Sincerely yours,
Fink, M.0.
Professor of Psychiatry
Max

Mi:kp

.

.

IV‘V-W

.
0
1

«any;

77.3w:

mﬂwvzm

�</text>
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                    <text>_

w—VW

V

Aer

15. 1969

Dr. Kenneth Lifshitz
Rockiand State Hospitai
Orangeburg, New York 10962
Dear Ken,
Thank you for your inquiry regarding our paper for
the Society of Bioiogicai Psychiatry. I had hoped to
present some information from our pentothai data but these
analyses have been more protracted than anticipated. Last
month I withdrew the report.
As

soon as our present studies are completed I wiii

be giad to send you a copy.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry,

Max

MF:kp

�</text>
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                    <text>April 17, 1969
Miss Jane Brody
New York Times
New York, New York
Dear Miss Brody:
I am

v;
.4

.
.3.

“(&lt;1ng

pleased to enclose two reports, soon to appear from

which may interest your readers. The work is
being done by two of our resident psychiatrists. Drs. M. Taylor
and R. Levine, and is of significance in our understanding of the

this Department.

pathogenesis of post-partum psychosis.

Two observations are clear: the onset of acute schizophrenia
in conceiving women inhibits (destroys) male offspring, for only
female infants are born to mothers who conceived within one month
of an acute psychosis; and. the onset of acute post-partum forms
of schiZOphrenia is associated with the birth of male infants.
Both observations are consistent with a concept of a hormonal or
humeral substance which stimulates an acute psychosis, transfers
from mother to fetus and is inimical to a male fetus. Further, this
substance is antagonized (inhibited) by substances from a male fetus,

and come

into active play,

soon

after

a male

infant is delivered.

Two reports are enclosed - "Newborn Sex Ratios Associated with
and Post- Partum Process Schizophrenia" has been accepted and is
soon to appear in Science; "The Interactive Effects of Maternal
Schizophrenia and ﬁffspring Sex" has been submitted to the Society
of Biological Psychiatry and will be read on May 3, in Miami Beach.
Pre—

m-

1.
cm

;

513,729:

fﬁmgqms

tijwwwlpmwmp

'A'NWWWWW

pleased to tell you also that the Section of Neurology
and Psychiatry of the New York Academy of Medicine and the New York
Society for Clinical Psychiatry cited these reports as the best
psychiatric paper at the annual residents presentations in February;
and the Society of Biological Psychiatry will award them the l969
I am

A. E. Bennett

Clinical Science Research

Award on May 3.

in partial fulfillment of elective
requirements in the Division of Biological Psychiatry of this
Department. We may be reached at 369-8488 or 369-7900 (x 245)
for furhter information.
The work was undertaken

I

trust this is of interest.

“537»:

Sincerely yours,

Mr.

‘,"§E%§1Wﬂ,mf’f“fxtb

Fink, M.D.
Professor of Psychiatry

Max
'

:‘I‘EWi‘Wfflﬁ

('1'?

MF:kp

�</text>
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,.

4,

my...

April 16. l969
Dr. Richard Hendrick

Arthur
15

D.

Little

Acorn Park

Co.

Cambridge, Massachusetts
Dear Dr. Hendrick:
have discussed with Dr. Pars, I am sending you
be
ampule of THC with a request that
an
separately
analyzed for its content. This is one ampule of 50 that
we received from Dr. Albert Manian and Dr. Daniel Efron
of NINH. The ampules were marked as containing l0 mg THC
As we

per

2 ml

of

it

95%

ethanol sealed under nitrogen.

In some of our recent trials we have had less of an
effect than earlier and are anxious to determine if deterioration
has occurred.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>«m—wu 0-w-

April 17. 1969
Miss Jane Brody
New York Times
New

York.

New

York

Dear Miss Brody:

pleased to enclose two reports, soon to appear from

I am

which may interest your readers. The work is
done
two
by
of our resident psychiatrists, Drs. N. Taylor
being
and R. Levine. and is of significance in our understanding of the

this Department.

pathogenesis of post-partum psychosis.

Two observations are clear: the onset of acute schizophrenia
in conceiving women inhibits (destroys) male offspring, for only
female infants are born to mothers who conceived within one month
of an acute psychosis; and. the onset of acute post-partum forms
of schizophrenia is associated with the birth of male infants.
Both observations are consistent with a concept of a hormonal or
immoral substance which stimulates an acute psychosis. transfers
from mother to fetus and is inimical to a male fetus. Further, this
substance is antagonized (inhibited) by_substances from a male fetus.

and come

Two

into active play.

after

soon

reports are enclosed -

a male

infant is delivered.

”Newborn Sex Ratios

Associated with

and Post- Partum Process Schizophrenia” has been accepted and is
soon to appear in Science; "The Interactive Effects of Maternal
Schizophrenia and G??spring Sex“ has been submitted to the Society
of Biological Psychiatry and will be read on May 3, in Miami Beach.
Pre—

I am

pleased to

tell

you

also that the Section of Neurology

of Medicine and the New York
Society for Clinical Psychiatry cited these reports as the best
psychiatric paper at the annual residents presentations in February;
and the Society of Biological Psychiatry will award them the l969
A. E. Bennett Clinical Science Research Award on May 3.
and Psychiatry of the

New

York Academy

The work was undertaken

in partial fulfillment of elective

requirements in then Division of Biological Psychiatry of this
Department. He may be reached at 369-8488 or 369-7900 (x 245)

for furhter information.
I trust this is of interest.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

:n“

�</text>
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                    <text>.

V

.-.,.«-w~-w.-W-~-r~r‘w1-m‘m.u.m.m“mm-7.." .u—v—wnvun .vuun u...» w—z—W~

..

,

.,,.,.,_,.

. m."—

w.-.wm,.

V.

“or“...

.,.v..—..__~n.

.w.

u.

7

,

,...

.

.

w

-.-.

Av

1
,

mm”?

7‘.

"mm.

April 17. 1969

war-r

Dr. E.

A

atix:3':ximmm‘

m

.n‘GWWZ-w‘w‘wu

\W.txw”‘vw.'v

\‘W‘.7

I“.

J. Preston

A. H. Robins Company
1407 Cummings Drive

Richmond, Virginia

Dear Dr. Preston:

Re:

Tybatran Laboratory

for not submitting the enclosed data
when
earlier. but the data has been misplaced until this week
additional
the
Enclosed
I reviewed our fenfluramine data.
are
records of laboratory tests in narcotic addicts assigned to
Tybatran treatment. The data filed earlier was that available
in patients who sustained treatment. Each of the patients in
I must apologize

the present group withdrew from treatment before repeated
laboratory tests were completed.

W?

Please add these records to those filed

r;

earlier.

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

.

.

ﬂ

,

�</text>
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«aw

{mm‘rr.'='w'v"

April 17. 1969
Dr. Edgar Grunwaldt
Goigy Pharmaceuticals

Ardsley,

New

York

Dear Ed,

time ago you requested that ketimipranine be maintained
longer than 6 months in continuous treatment. We reviewed
our casewload and the 6 patients in extended treatment were
transferred to other antidepressant therapy. They ranged from

for

3%

Some

no

to 7k months

on

ketimipramine.

In reviewing the laboratory data we found similar incidences
of values outside our established limits for ketimipramine and
placebo. The incidence of out of range values for this sample
is no greater than that observed in this clinic with other compounds,
includ ng cyclazocine in similar groups of depressive patients.
The out of range values are circumscribed in red. The drug code
is A-K for active ketimipramine, P-K for placebo.
I

trust this data is useful.
Sincerely yours,

«qr—mm

rruruw

am

Max

r"

v,rY"‘-"

Professor of Psychiatry

tavm'ruu

wtr-yvzw

F‘nk . ”o D.

Mszp

�</text>
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‘mvgmmmmam-w "a..."

m

&lt;

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/-

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u...

April

u
,

l8. l969

Dr. Richard D. Walter
International Congress

,r—

w

nwn

wvww-avm.

Neuropsychiatric Institute
Los Angeles,

California

w

c-N'Yi'mwm“"

Dear Dr. Halterw

4.

W"V’

from

w-n-rw-

I am pleased to enclose two abstracts of
reports
this laboratory for your consideration for the forthcoming

International Congress of EEG. The reports are based
collaboration with Dr. Itil in St. Louis.

'

begun in

mu-wvmmwm’w'"

.

and

We

on

studies

look forward to participating in this Congress.

to meeting with you.

once again.

Sincerely yours.

"
~

:
rv-

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v4.

W

..

r
.

,

r
l

--—

A

w...w-zmz—;-v—rcvm

_

'
UP

WWW“?

W

aw“

“WWW

Fink, M.D.
Professor of Psychiatry

Max

W'm—wwrrwn—

.

�</text>
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our

Inn/m...

rm

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&lt;._u'"“3lm'

April 18. l969

~

"you

“mm,"

Dr. Richard D. Halter

International Congress

Neuropsychiatric Institute
w

Los Angeles,

;
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California

«w

Dear Dr. Halterm
uwww1ruzv"..,qmw

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qu'w

'31-

from

I

pleased to enclose

of reports
this laboratory for your consideration abstracts
for the forthcoming
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two

International Congress of EEG. The reports are based
collaboration with Dr. Itll in St. Louis.

begun in

on

studies

uw‘V'Cz-‘A-J'Wﬁ

r331.

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and

We

look forward to participating in this Congress,

to meeting with you.

once again.

r“
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Sincerely yours,

gasmﬁﬁpﬂ'

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Fink. M.D.
Professor of Psychiatry

Max

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W

,

mm'mwvw mnwymwmwwﬁ—u-m..

W

sum-nun“.

April 21. 1969
Dr. Edgar Grunwaldt
Geigy PharmaceuticaIs

Ardlley,

New

York

Dear Ed.
Our ketim1pram1ne study is continuing and we would
appreciate 10 x 100 placebo GY~2277.
My

best regards.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

'71.».qu

Max

A

MF:kp

—

�</text>
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                    <text>April 21, 1969
Dr. Norman

Pitts

Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Norman,

.‘

Would

«my...

‘:uF?--mt,w~‘

it

be possible

for

us

to receive

3 x 100

are completing our Doxepin study

capsules placebo?
and I think this would be sufficient until termination.
We

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
5;.

a;
«1;

1a
1*

“"1

MF:kp

war?

“55.13"”

’.“I'-F*£VW?¥'?"

aw

magewmwmmmr

gag/‘22:

~.
122;?

g;
y
‘,

ru‘vrn

-

\
wu-

V

..,'

”wan,

mama;

"1

W‘s:

Fl

�</text>
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                    <text>April 21,
A

1969

Dr. Allen P. Berger, M.D.

Pfizer Pharmaceuticals
Groton, Connecticut
Dear Dr. Berger,

on

CP—

Itil.

I have rovicwod tho letters and the clinical data shoots
larger folder to my consultant. Br. Toron
Tho FD
1A,368; and cent the
1572

is onclooed.

Before completing a proposed protocol. I would like to have
the benefit of Dr. Itil'a comments. It will also be notes-ary to £11:
a protocol with our College authorities.

I note in your letter a desire to undertake this study before
the end of April. I regret that such a timo~tablo is not foaaiblo since
I would like to carry out thoue studios myself, and I am committed to
a oonforoooo and none pita vioito in Europa from May &amp;«20. we will be
able to run our initial trials during the first week in June and carry
out some of the exporimonts until late July when I anticipate a oumnor

hiatus.

I trust this

timo schedule

is acooptoblo.

ﬁany thanks for the Opportunity to review the notes and to
propose a study of CP~14,368.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>April 21,
Dr. Torso

1969

Itil

Profoaaor of Psychiatry
Missouri Inatltute of Psychiatry
St. Louis, Missouri

Ref:

CP~

l&amp;,368

Dear Torso,

For some time I havo expressed tho desire to examlno
potential psychoactive compound in the EEG analytic scroen,
without tho utual animal or clinical olues, which could influence
our EEG evaluations. Dre. Betas: and Pitts of Pfizat Medical Research
Laboratorlen havo mods such a otudy possible. and I am writing to ask
your assistance.
-

a naval

‘

Enclosed is a cepy of tho available animal and clinical
pharmacology data, an augplitd by Dr. Berger. 1 would be grateful
for your reviuw of this notorial and your toaponse to the following
question:, which I propose to use in formulating a daftnitlvo pilot
A: I would like to start with singlc, oral dosagao in young
study.
(21»35 yearn) male voluntoero, the questions aro:

what dosage should be tasted
what incromonts should be tested ?

initially

?

If

no

effect,

‘rr'r‘n

~

tear.

a

egfocts

7

At what time
What

~svr¢x,ys;rﬂf”vrt=v'm,~

-'

é

in the

reviaw of the data

intorvala can
maximum dose

7

-'

.

*

r-‘u.~"

«damp

a;
~19

anticipato clinical and/or

that should

EEG

be toatod beforc your

effects should ho tested for most carefully 7
secondary effects are experienced, what are the prohibited

what secondary

Aneuming some

antagonists? the preferrod,

”

wt

What

if

are the primary

known ?
EEG

leads to be examined?

Any behaviorol questions that may be anticipated in addition
the
one: included in the Clyde Mood Scale, which we have used in
to
these studies to date ?

�'-

x

{A

1:11

0

I

I

a

o

I

o

0

2

a

I

O

.

.

.

.

.

April 21,

I would like to begin these studieq about June 1, and would
appreciate the opportunity to discuss this with you beforo the APA

meetings in May.
Many

thanks, and

“\i.
"\x

my

best regards.

\.

\‘i
5

u

‘\

\\

Sinceréﬁy yours,

Max

Fink, M.D.

1969

�</text>
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                    <text>April 23, l969
Mr. James

J. Flanagan

Director of Sales

The Park Sheraton Hotel
Seventh Avenue and 56th Street
New York. Haw York 10019

Dear Mr. Flanagan:
The Council

of the American Psychopathological Association

is desirous of changing the format of its

program and

for this

reason request cancellation of the meeting to have been held
at the Park Sheraton Hotel on February 12-14. 1970.
I wish to take this opportunity to thank you for
your
splended couperation during the past many years.

Sincerely yours,
Fink.
Secretary
Max

MF:kp

H.D.

�</text>
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                    <text>April 23, 1969

Sesata
Sales Representative
The New York Hilton
1335 Avenue of the Americas

Mr. Joseph E.

New

York,

New

York 10019

Dear Mr. Sesata:

Following our discussions and your memorandum of March 28,
iike to reserve the Mercury Bailroom and Promenade for
meetings of the American Psychopathoiogical Association on
Friday. February 13, and Saturday, February 14, 1970. would
you piease arrange the necessary documents for our signature?
we

would

Sincerely yours,
Fink,
Secretary

Max

Mszp

M.D.

�</text>
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                    <text>hpril 23.

1969

Dr. Ivan F. Bennett
Illly Research Laboratories

The

Eli Lilly and

Company

Indianapolis. Indiana

46206

Dear Ivan.
I regret that our paper "d-cyéloserlne 1n the Therapy of
Psychosis“ has not been published. The draft sent to you has

not been prepared for publication.
Thank you

for referring

Dr. Thomas

pleased to answer any questions that he
My

to us.

may

and I would be

have.

best regards.
Sincerely yours,
Fink, h.D.
Professor of Psychiatry

Max

Mszp
.-

.m.

.‘Twnwuwav

a.7,.....~.--v.«worm—l

,‘

,.l.

�</text>
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                    <text>——‘-w

wr'

pvv

w.

—u-.--«.yv

WWW&lt;

April 23. 1969
Dr. Jonathan 0. Cole
Superintendent
Boston State Hospital

Boston, Massachusetts 02124
Bear Jonathan,
I am very

very grateful for your enthusiastic

letter

regarding the ECT Manual. Your request for so many copies
and your suggestion that it be published led me to review
the manual and I have made a few modifications. particularly
in the theoretical sections. This is being typed and I am
going to submit it to the American Journal of Psychiatry, hoping
that they will accept their educational Tbnction.
which

In the meantime, I will arrange to run off 50 copies
be sent to you within the next few weeks for

will

distribution to your staff.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>)'~=Wv'1'rl“»’"4

("WY

new,”

7

m.

..

T0:

Dr. A. h. Freedman

FROM:

Dr.

SUBJECT:

Dr. Frederick Beekeland

Max

DATE:

April 23,

1969

Fink

and I have had an opportunity to meet
and
to discuss his proposed program.
Dr. Baekeland
ﬂy

associates

I found him knowledgeable.

experienced but tense and

anxious.
principal interests are in sleep research with
the
manipulations of deprivation of various stages
on
emphasis
and
there effect on mood and effect. He expressed
of sleep
of sleep research except a passing acquaintance
outside
no interest
His

with alcoholism.

principal activities at
in teaching medical students.
His

Downstate Medical Center

is

Impression: Considering the large number of sleep researchers
I am not impressed that he has sufficient novelty in his approach
research.
or enthusiasm to warrant appointment in this area of
I found him to be restricted in his interests and I wouid wish
to inqdire of his superiors at Downstate whether this restriction
does not carry over into his teaching.
MF:kp

�</text>
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                    <text>April 23,

1969

Mr. Don Choctham

Smith, Kline

&amp;

French Laboratories

Philadalphta, Pa.
Dear Don,

for the oxcellent survey of Manifontations of
Dermatitis asaocioted with 'Thornzine'. The roferencas did include
some that I had not found, and I am now, more than over, prepared to
Thank you

dofond the proposition which has become the subject 0! a court
Many

trial.

thanks.
any chance that you will be in
opportunity to V101: our liberatorieu this

Incidentally, is thoro

ﬂew York and have an

spring

?

Sincerely yours,

'

Fink,
Professor of Psychiatry

Max

M.D.

.

Diroctor. Division of
Biological Psychiatry

�</text>
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                    <text>~

‘m

me'wmn

—_ WV... WY“

April 24.

1969

Dr. Moressa H. Orzack

Boston University School of Medicine

Division of Psychiatry

80 East Concord

Street

Boston, Massachusetts 02118
Dear Dr. Orzack:
I

Thank you very much for your letter and curriculum vitae.
very mach admire the work of Drs. Mirsky and Kometsky and

I am

interested in similar applications.

It would be very helpful to have you visit this laboratory
at your convenience. Unfortunately. I will be away from May 2
through May 20, but if it is possible to visit before May 2, I
shall gladly set aside the time.
Please call

my

office at (2l2)

369-7900 Exg. 245.

Sincerely yours.
Fink. M.ﬂ.
Professor cf Psychiatry

Max

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                    <text>April 25. 1969
Dr. Arthur H. Epstein
1430 Tulane Avenue
New Orleans 12. Louisiana
Dear Arthur.

find that I will not be able to attend the American
Psychiatric Association meetings. and I am listed as Chairman
of the session on biological psychiatry. As cowchairman will
you accept the responsibility for the session?
I

If you find that you are unable to be at the meeting,
would you please arrange with Dr. Rothrock to be chairman?
Sincerely yours.

lax Fink,

M.D.

Professor of Psychiatry

ﬁF:kp

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                    <text>[We

NWT—"y".—

(212) 369-7900 Ext. 245

April 25. 1969
Mr. Robert L. Marlin

Sandoz Pharmaceuticals
New Jersey 07936

Hanover,

Dear Mr. Merlin:
I have read the preliminary data on Sandoz 42-548
with
interest. It is possible that we can undertake an EEG profile.
but the earliest wouid be after the summer holidays.

I am enclosing

reprints describing our work as well as a
report of our observations in another anorexigenic.
fenfluramine.
preprint of

a

a

As an example of our approach
study of another compound.
As I

would you

I am

enclosing a protocol of

will be out of the country from May 2 to May 20,
my office and arrange to visit soon thereafter?

call

Thank you

for your interest.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

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                    <text>r“. W,,,

“m“, _,,,,__

,

W.1w_.wmmmwvmn
,

r

, .4,

”w.—wm.mw Wu ”Wm
. we ..._ .

.

M

’w-W,_mnu._ww .w e—inww—n—r W

Wr'w—v-«mm‘lﬂ-v-mm

w!

v

m—mmmAW—‘VW~N,—

April 28,1969
Miss Ellen Kaplen
E. R. Squibb 3 Sons. Inc.
909 Third Avenue
New York, New York 10022
Dear Miss Kaplan:

is

a revised summary. including all the
you suggested. in only one instance (VI) could
I not follow the suggestion - and this because my notes
indicate this to have been reported. and not to be in his
be from another reference of
written report. Could
Simpson's not known to me? Perhaps you would send the
paragraph to him for his comments.

Enclosed

corrections

it

I presume you

don't wish the xerox copies of the
if so. they are in the file.

papers returned. but

Sincerely yours.
ﬂax Fink, M.D.

Professor of Psychiatry

�</text>
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www.m-

~vy-w‘wglm

r

m” ..'.,_..wm

v. .,~.—w..:-...

Wu.

i...

—.

\mw—mwnwnv .

V

w, was"

“.1...

V

..

., .—.__.__s.—.v_ WV ....._.~_.a v...._.._..__.._._r‘

April 28. 1969
Dr. 6. Richard Hendrick. Ph.D.
Arthur 0. Little. Inc.

Acorn Park

Cambridge. Massachusetts 021d0
Dear Dr. Handrick:
Thank you very much for the analysis of our sample of
It was most useful having the assay from ﬁrs. Manion

A9-THC.

and Efren.

It is

my

interpretation of the data that there

has been a degradation of the a9-THC and for practical purposes
reduction has been approximately 10% with increasing amounts
appearing as a“ and N-3.
In retrospect a possible explanation for this degradation
has been that our samples have been maintained at approximately
5°C. which may not be adequate.
we

are very grateful for your help.

"Yﬁmwxwmamm

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max
rtwcsz-wmn

“are

"I!“

I'"
‘
1-

'P‘T.‘

v

mm

«1?.

'.Js.I'-'z'r-‘

am

am.

‘W

WWI-'1':

.

MF:kp

�</text>
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V—w«_r~___.—,v._.._,_.~._t

April 28.

v..___ -w__em. .V.

.

v..e.,e.-_r.q__ .______... ,V.___, fer.

1969

Dr. Walter Modell. Editor
Pharmacology and Therapeutics
Cornell University Medical College
1300 York Avenue
New York, New York 10021

Clinical

Dear Dr. Modell:
Many thanks for the careful review and criticism of our
report “Clinical Antidepressant Activity of Cyclazocine - A
Narcotic Antagonist“. we have adopted the specific suggestions.
which have materially improved the presentation.

It is difficult to respond to comments of redundancy and
our inadequacy. Redundancy has been reduced. but we are
reporting the observations in two studies. with different
populations, dosages. rating scales and personnel. For
accuracy, we believe it necessary to report what we know and
did. Any additional suggestions would be appreciated.
Our inadequacies are well known to us. Cyclazocine is
useful in treating opiate addiction. an illness with limited
economic interest to the pharmaceutical industry. He suggested
trials as an antidepressant based on our EEG criteria. They
were met with indifference by the representatives of Sterlingwinthrop. Our initial trial was interesting to us but to no
one else at NIHH or Sterling-Hinthrop. Recently. Schiele
and Abuzzahab have undertaken a similar study.
we carried out a second trial in a mental health clinic.
Such 0P0 studies were new to me. and we found the drop-out rate
high. At first we thought this related to cyclazocine, but we
found similar drop-out rates with other drugs and populations

in the

same

clinic.

,

V

,,

w, 77‘-.._,._,,V,._

«WV,

ﬂ ,,

,

,

,

�VFW—.WWWW “v" WW,

———.—..p

-2-

Dr. "Odell

April 28,

1969

pilot study data. reported here. was sufficiently
interesting for us to propose a direct. random assignment
study against inipranine. But we could not support this
stud . and while we vacillatad. the IND was withdrawn by
To
out a definitive study. would
The

Star ing-Hinthrop.
carry
require our own IND. new innds. 355,
But. we believe cyclazocine to be as active
.

as imipraeine.

Should

this not

be reported

-

an antidepressant
somewhere, somehow?

Incidentally. the naloxone studies have been re-instituted
(in part because of the report published in OPT) and the pilot
studies now include single daily dosages to 1500 age with
antagonistic activity observed to l8 hours against 50 mg
intravenous heroin.
I do not know

observations. It
Thank you

if

CPT

is still interested in the cyclazocine
- without prejudice. if unacceptable.

is enclosed

for your consideration

and

patience.

Sincerely yours.
Fink. H.D.
Professor of Psychiatry

Max

fokp

�</text>
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                    <text>Apr‘l'l 29. 1969

Mrs. Werner. ECDEU
Chevy Chase Motor Lodge
8130 Wisconsin Avenue
Bethesda. Maryland 20014
Dear
and

ﬁrs.

Werner:

I look forward to attending the ECDEU meetings on June 5
1969. I have asked Dr. Jovan Sinaon to attend the

6,

meeting as wail.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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-

__

-.

a».

_

v“,—

—.~-.

.9, V.

,, ...w

mr.uﬁ_. vmm,_—w:r'_7

:

Aprii 29. 1969
Dr. V. G. Longo

Istituto Superioro di Sanita
Viala Regina Elena. 299

w-

Rm. Italy

‘W.,...AW,.-vaww’w-mw

Wm-"

Dear Dr. Longo:
Thank you for your invitation to participate in the
Program Committee of the CINP in Rome. I vii] be arriving
on Monday evaning May 5 and will cail you when I arrive.

Sinceraiy yours.
‘

H

Fink. H.D.
Professor of Psychiatry

Max

3

:

wm'w.rv

—&lt;—~

v-

wy-v-w-

W.

a

mu

Mszp

,

�</text>
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                    <text>January 2, [969
Dr. Craig Burrall
Sandoz Pharmaceuticals

Jersey

Hanover,

New

Dear Dr.

Burrell:

Thank you very much for recommending our program To
Dr. Quinnell. My lefter To him has gone ou? Today and
hope The? fhis program will receive +he cooperaflon of fha
P.M.A.
1

Thank you for your

inferesf.
Sincere{y yours,

Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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                    <text>January 2, i969
Mr. Josoph L. Packard
Packard Associates
3 Hator Lana
Monhassot, New York ii030

‘

Dear Mr. Packard:
Thank you very much for your iettor of Docombor i0.
havo discussed the opportunity which you presented with
two of my associates and so for, notthor on. is available.
i

E

i

i

shall

koop

this opportunity

in mind.

Sincerely yours,

g

f
P

i

Max

rm«..—.r

Fink,

M.D.

Professor of Psychiatry

:—-&lt;

wan—u.

‘U‘v—W'vwrw—

w—wvu—

‘

r
ru—r

~

“I'Wrrlvzur-ﬁrww‘

-—-w-

.-

Twammnm’wmmwxm-

\

Mszp

�</text>
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                  <elementText elementTextId="105727">
                    <text>January 4, ‘96!
Dr. Louis Levy

Ill Park

New

S?

Haven, Connocflcu?

Dear Law,
O

am

fho notes you

sorry fha? if has Taken
requested. bu? they were

associates in Missouri
nofos are affached.

and

hava

!

me

In

so many uaoks to frack dawn
the hands of one of my

Just received

fham. Your

crigtnal

-

Whtio we aomplefad sfudtes of cyclosertna In psycboflc
paflen?s, the numbor of subjects was 100 small #0 provide a definite
E28 éa?a. Those addi?lonal s+udias «are
report wtfhour adli?tona!
}
£af+ 5+. Lauts and have not been compiefed. if Is
tn progress when
fhe lmprossion of my assactafo (and also msua) #haf cyciosarlnc may ye?
be usefu! In the symptom provecafion fraafmenf of schizophrenia.
Thanks again for fhe oppor+uni+y #0 read +hese nofes.

Sincaroiy yours,
Max

mf/

Fink,

M.D.

�</text>
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                    <text>i
Iv‘v‘:&lt;

‘ru

‘

'_'.'v

I

\VC
'1‘

.z‘.
mini“

January 6, i969
Dr. Walter Essman

Department of Psychology

Queens College
Flushing, New York li367_
Dear Dr. Essman:

.Dr. Dornbush and my other associates were indeed very
grateful for your vibit to Gracie Square Hospital. The
suggestions of the biochemistry whichi may underlie memory
patterns were very illuminating and believe provide some
help in our studies of memory.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
871C .

‘

�</text>
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                    <text>January 7, 1969
Dr. William Guy

Biometric Laboratory
Washington, D.C.
Dear

Bill,

Enclosed is a summary of the otudies previously listed
with the Biometric Laboratory from this unit, and their preuent status.

I

have

rocently

had two

additional

members

join

my

staff

and

find that we have only one complate manual for ECDEU assessment (as
rcviaod July 1968). If othar copies are availabla, I would appreciate
two additional. If not, I will hnvu the copy xoroxed.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry
MAX

mf/

mm"4.7'-:.

.

�</text>
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                  <elementText elementTextId="102816">
                    <text>January 7, l969
Dr. Thomas V. Kalcher
Gelgy Pharmaceullcals
Ardsley, New York l0502
Dear Dr. Kalcher:
GP

Enclosed Is a deflnlflve profocol for The sfudy ofTo
fhe
4l299. We would propose a slep—wlse approxlmaflon

cllnlcal evaluaflon
lf fhe

flle

program

of

lhls

for

The

compound.

lnltlal

EEG

lrlals are sallsfaclory.

lhe prolocol wlfh our Commlffees.

we

wlll

To

flle the necessary

In such slralghf—

forward sludles, approval ls generally avallable wllhln 4 weeks.
Thls wlll provlde an opportunlfy for us #0 select subjecls and
forms

for lhe

FDA.

capsules
If +hls prolocel ls accepfable, we wlll requlre 50lnacflve
of
an
25
capsules
of 25 «9 GP 4l299 and, If posslble,
dexfrose.
lacfose
or
as
placebo,
Thank you for lha opporfunlfy of preparlng lhls profmcol.
Slncerely yours,
Flnk, M.D.
Professor of Psychlalry
Max

Mszp

�</text>
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                    <text>T0:

'BOARD OF VETERAN'S APPEALS

Washington, D.C.

FROM:

Fink. “.0.
Arieigh Road

Max

39

Grunt Neck,

Subject:

New

066—18-2080
York

Consultation Fee

For consuTtat1on report} dated January 6, 1969.
Tomkin Buckles
concerning
0116
C

18 056 379

$100.00

�</text>
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                    <text>WWW

wm-

January 7. l969
Mr. James H.

Stencil

Chairmen, Board of Veterans Appeals
Hashington. 0.6. 20d20
Dear

Sir:

Re:

Buckles. Tompkin

C—l8

0116

for

Following your request to Dean

056 379

J. Frederick Eagle.

H.D.

psychiatric opinion in regard to Mr. Tonnkin
Buckles. I reviewed the records submitted in two folders one from the V.A. and one from military service. The questions
raised in your letter of December 5. l968 are. whether ﬁr. Buckles
has a chronic acquired psychiatric disorder; and if he does.
when manifestations were first shown to be present.
an independent

I have reviewed

service

these records. Hr. Buckles entered military

from a small rural community in Tennessee in July l948
the
at
age of l9. He stated he completed 8th grade. was considered
literate and achieved e score of 70 (borderline) on the Rad test
(30 July 48). He served in Japan and Korea and first sought medical
care on return to_U.S. in Aug. 52. complaining of headaches since
Jan. l952. -$ubsequently. he has repeated admissions for evaluations
of liponate and multiple somatic connlsints. interpreted as nondisabling. The record speaks of AHGL end stockede; of demotion
from Sergeant; and finally of discharge 4/54 with 30% disability

for lipomote.

The record is silent until l958; an entry in September. l962;
end l965 to date. The requests on each occasion are for increased
compensation. while the social history is sparse,
seems he
returned home and did not carry; he worked on his mother's
fern l954~l957; then went to Michigan for a loborer's Job; and

it

was

to

discharged when e strike occurred. Thereafter. he continued
for his mother.

work

�Mr.

Stencil

-2—

January 7, 1969

Various psychiatric evaluations are recorded. The first.
cost complete. is dated Aug. 5. 1952 (Fort Campbell. Ky.).
This relates chief symptoms of headaches. borderline blood pressure
and many somatic complaints. The history of headaches begins in
January 1952. The diagnosis is passive aggressive personality.
Subsequent reports are similar, none defining a more active
psychiatric condition. and each defining a personality disorder.
The record of June 1966 is the first to define more focal symptoms,
as “voices telling him to 'rubout or kill people" and 'an
alcoholic problem that had caused 4 or 5 arrests for public
and

intoxication."

other clue is present in the report of 8/23/54
alleges discharge 'for low 10“ after 6 years service.
One

which

9313.121

l.

disorder?

Does Mr. Buckles have

a chronic acquired psychiatric

record portrays an uneducated rural worker
of borderline intelligence and limited schooling. 0n induction.
his military adjustment is satisfactory. as evidenced by the sergeant’s
rating. In l952. the demands exceed his resources. 7Combined with
the thread of return to a discouraging civilin role. results in
pleas for help expressed as a plea for total support ("compensation“).
This is denied. and he adapts less and less adequately with more
somatization demands. His social. marital and Job adjustments
are equally unsatisfactory. Alcoholism is present. In the military
he was best protected. and to meet his needs he demands core
"compensation‘.
The

’

He evinces no psychiatric “disorder”, but a lifelong inadequate
adjustment. This was‘not acquired in adulthood. It was present
before military duty. It is now chronic. Based on this record,
(30l.82);
the USN-II psychiatric classification is Inad uate Personalit
retardation
secondary classification is Borderline mental

agdothe

�Hr. Stancil

2.

when worn

January 7. l969

~3—

manifestations

first

The record

indicates a ecompensa on ocaoo moo grosont?
est during the period
Jan. to August l952 and has continued.
3. gn_yhot is opinion based?

records.
I

to Professor of Psychiatry.

The
New

facts cited in the submitted

York Medical College

l966): formerly Research Professor. washingtoo University.
goince
l962-l966). Certified in Psychiatry (1954) and Neurology (l952).
Licensed to practice in ﬂow York (1946) and Missouri (l962).
Graduated New York University College of Medicine. l945.
Sincerely yours.
Max Fink, H.D.
Professor of Psychiatry

Mkap

�</text>
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              <elementText elementTextId="37163">
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  <item itemId="3715" public="1" featured="0">
    <fileContainer>
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                <elementTextContainer>
                  <elementText elementTextId="102813">
                    <text>January 8, 1969
Dr. Milt Kletzkin

Wallace Laboratories
Cranbury, New Jersey
Dear
_,

,
i

A.“

Milt,

Enclosed is a draft copy of our report ”High-Dose
Tybamate Therapy of Heroin Dependence“. It is my understanding
that this is for your personal use and is not for distribution

to others until after

v
4.,

,
.«_

it

appears in the public press.

,—

Hy

best regards for the

New

Year.

("I-vmm'vwr-wgl)

Sincerely yours,
.

gar-w-aur

Max

;~m:'~r-

:m.

.

Fink,

M.D.

Professor of Psychiatry

.-

Mszp

�</text>
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,.—u--,wr

January 8, l969
Dr. Theodore Rothman
Executive Director
Rush Research Foundation
920l Sunset Blvd.
Los Angeles, California 90069

Dear Dr. Rotnman:
Enclosed is a corrected final draft, including a
replacement figure for our paper ”Depot Fluphenazine
Facilitation of Treatment of Psychosis" for your volume.
If you would like these corrections put on the original,
which you have, please return the original to us.

Sincerely yours.
.

"—

Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC .

7

euguuem.“

_.

e

7547.7

,,,

W”;

i

,

egg-M .4143:

g, ,

Jﬁwgﬂmnse. ”ca—Mew

7,.

e

,

A

.72..

�</text>
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                    <text>January 8, 1969
Dear Jonathan,
La may be intarested in carrying
of offspring to schizophrenic mothers.
of
the
sex
studies
out concurrent
and a praprint of the report aub~
ch:
article
am
original
I
enclosing
minted to Science. An additional raport 05 the problem of poat~partum

I

am

pleaaad that Dr.

psychoais and the offagring sex is being typed and will be sent to you

shortly.

my

best regards.

E

Sincerely yours,
Mn: Fink, M.D.

Dr. Jonathan 0. Cole

Boston State Hospital
Boston, ﬁasa. 02124

�</text>
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                    <text>January 9.
Dr. $1133 Braley

Dav Corning Center

Midland, Michigan

for

1969

Aid to Madical Egaenrch

Dear Dr. Braley.
Thank you

far your

meat infarmative éiscussian and the
reply.
wera'quite remarkable, and the patant
application for a Silicone carrier for drugs was most helpful.
It in apparent that this mathod may be useful in two of the problems
of direct interest to ua~~ the treatmaat of opiate addiction anﬁ
of chronic ptychoais. In addicts we weuld be intcrastad in the
continuous slow raleaaa at a nercatic antagohist, such as cyclazocina;
and in psychosis, the release of an antipayahntie like the cannon
prompt

The papera

phenothinminea or thiaxanthanea.

I will take the material that you nan: and prepare u ruport
to on: staff. As soon as we have giltified our interest, I truat I
may write to you for further advice.
hany thanks for tha opportunity to became acquainteé with
an important medical advance.

Sineuraly yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>Januaty 10,

1969

Dr. B. Blackwell, M.D.

8. Merrill co.
Cincinnati, Ohio

Wu.

Dear Dr. Blackwell,

I have read both the information btochuro and the proposed
protocol for otudios of Bimothocrin in dopreasivo disorders. While such
problems are of interest to this laboratory, we have recently decided that
our energies were better spent in the analysis of EEG profiles of new
compounds. to determine the logical populations of risk and the classification
'

of the compund.
Snob

special interns: to
chemical structureo, and we would be pleased

profile analyses

havo boon of

industry in the study of new
of interest to
to review the animal pharmacology of oompoundo that oro boon
decided by
hovo
you. The oloasifioation of this compound seems to
Co.
has
apparently
tho Swiso workers and the research staff of ﬁerrill
If this interpretation is incorrect. and
accepted this determination.
chore is intoroot in teviowing the population of risk for Dimethacrin,
I would be pleaood to review the data with you.
.Good luck

you

at the next

itself.

in your

ECDEU

new appointment, and

meeting, at

I look forward to meeting

earlier, if the opportunity presents
sincerely yours,

I

mf/

max Fink, M.D.

�</text>
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                    <text>Jammy 10,

1989

Pitts

Dr. Nmaan

(has. Pfizer

8 (Emmy
Oameotiout
Gmton,

Dear

Harm,
Enclosed

.
«
u.

7.

‘W

w

told
as

you

v.w;...,-..,

y

v...“

and when

I

was

were in Europe, I canolated the report as best

I could.

mats , as always, will be most welcom.

also enclosing a revised protocol for the
definitive mt; study (12-30~68). The earlier draft
had some terms in the EEG and Clyde scale data which
are corrected in this draft. Please destroy the earlier
I

.,,,.-1-v.u—.~«_—-w

smmary requested by Mr. Fimxan.

I called your office for clarificatim,
Your

W"V‘R”,"V—“WHVV‘I’

is the

am

draft (Hemmer 29,
My

1968) and mplaoe with

this

copy.

best regards.
Sincerely yours,

”(7-1..WT,”

-7...

Fink, MD.
Professor of Psychiatry

Max

MFﬁcp

�</text>
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                    <text>.-

,

January 10, 1969
Dr. Turnn

Itil

University of Misoouri School of Medicine
St. Louis, Missouri
Dear Turan.

Enclosed is part a! the consultation feet for your
participatinn in our program, ’EEG and Euman Psychopharmncology"
during the past few months, on your visits to our laboratories.

toes ($300) have bean requested and will be forwarded

The tamaining

promptly as received.
Many

thanks for your cantinucd

in this program.

1”,

my

1
a_—-.-

interest

and

asaistanca

best rcgards.

&lt;

“ﬂy-lava:

Sincerely yours,

«4.

-p-,

JwﬁWv-ﬂr.

Err-«(y

Max

m».;wx;n

ﬁ‘zv"w€'

mf/

Fink.

M.D.

�</text>
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                  <elementText elementTextId="102808">
                    <text>January l3, I969
Dr. McKeen Caffell, Edllor
The Journal of Cllnlcal Pharmacology
and The Journal of New Drugs
525 Easf 681h Sfreef
New York, New York l002|
Door Dr.

Colfall:

2, regarding
wlfh regard +0 your loffor of January
#ha? fhere
advlsod
be
allowances for pago charges, please
on behalf of
ls no cafogorlcal objecflon To such charges llmlfed and no
This Deparfmenf. However, our budgefs are
usual sources
funds have been made avallable *hrough fho
such as lndusfry for Thls sfudy.
l would
Before answering your lofler afflrmaflvely,
for The
approclafo a speclflc esflmafe of lhe charges
manuscrlpf In your hands.

Slnceroly yours,
Max

Flnk, M.D.

Professor of Psychlafry

A

'1',”

2?"W:%¢:"'t‘«v74nyw-

‘ﬁ’VT-‘Pav'ﬁ'

7’

my

a?“

m»

an

gp'zﬁwww'?f1w:.j;ﬁxf.-mm.'

‘ﬁ’fm

‘

Mszp

�</text>
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January IS, 1969

5. Treasury Deparfmenf
lnfernal Revenue Service
Mld-Aflanflc Region
U.

Genflamen:

Dr. Rhee Dornbush ls employed ln the Deparfment of
New York Medlcal College, 5 Easf l02nd_$+ree+.
While she was glven offlce space a? flls address, the

Psychlafry,

socrofarlel

and

offlce faclllfles

The work whlch she was

requlred

were

lnsufflclenf for

+0 accompllsh.

Sincerely yours,
Flnk, M.D.
Professor of Psychlafry
Max

MFskp

�</text>
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                    <text>1

1

A

.
_

‘

,w

WWW“

a.“

“ﬂaw“.-.ﬂ.

”......w. ., .

.._.~{.,,,.../_vmr..-.

"um. . .

..... V,._.7.,..,,,.,.... ....-.i

v .

V--wr-"fr7‘~“lmw|
x-

«w

s

,

January 15. 1969
.
my”

1

m‘prUfm-Vrlﬂrvmv-

Dr.

Philip

Boyer

iarion Laboratories. Inc.
P. 0. Box 963
Kansas

..

City. Missouri

64141

..._.

....Jﬁra‘

”aggrwm

”gum—n.”

Dear Dr. Boyer:

Enclosed is the revised protocol for the “EEG Identification
of Pyrovalerone (F 1983) Activity" as well as the FD 1572 and my

curriculum vitae.
Thank you

-

7
:vﬂv

for your interest.
Sincerely yours.

"ytfﬁwlﬂm'ﬂ‘wjr"

‘m

-

Max

v—I'T'rgw‘mr-

Wm.

"v

MF:kp

enc .

,.

-.

‘._-&lt;~

yaw;

_

r—«u—rm,

1v,»

-

r
m

u;

'IG'J‘;‘JI'-W_;'v,mn&gt;:-

.
,r

Fink. M.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="102806">
                    <text>H.246”:

TO'
FROM'

- f
.

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS

Dr. Gerald Strahs
Dr. Max Fink

=

DATE

1/15/69

SUBJECT

Thank you for brining the symposium of the New York State
Medicai Society to my attention. If you have a copy of the
program or can obtain it, I would be glad to sent it to each
member of the Committee.
kp

�</text>
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                    <text>January l6, I969
Dr. Ger? J. Schuller
Asslsfanf Cllnlcal Research Dlrocfor
The Squlbb lnsllluTe for Medlcal Research
New Brunswick, New Jersey 08903
Dear Dr.
.

Avryrﬂvr'pw‘:

«w

Schuller:

Separafely am sendlng you our fllo coplos of lho
record absfracfs for each case In The fluphenazine docanoafo/
enanfhafo sludles; as well as a wrlfe-ouf of fhe laborafory
I

dafao

:wﬁr"?

The lndlvlduol case records Include coples of The summary,
and vlslf records for each paTlenf in +ho sfudy.

~

«xv-a»

raflng scales

The laborafory dafa book confolns the acfual dale reporfs

WWWW

for each subJocf, lo

The exlenf colloclod durlng The sfudy period.
of lhe laborafory dafo report ls a copy of our
standards and fhls oeflnes fho upper and lower llmlfs for Thls

The
strewn-1min

flrsf sheaf

loborafory.

“3w:

,
gar-a

tyrant-arm.-

Ho would appreciate return of the records as soon as you
have complofed your review. The laboratory data slafemenfs
are The orlglnals, run for you, and tholr rofurn ls no? necessary.

Slncorely yours,

w:m%w‘r;hﬁ'ﬂw

n~

main-:1

Max

;;
r:

"m,1'f?~“

«7
:rsw‘

:v
-

.4.
o—

2:13»;

MP5

-,
“5mm

57¢“?u-1,

L
V.;.

A

i4’wyrnv'mlen

.732?

17/.‘c'wa

at

Flnk,

M.D.

Professor of Psychlafry

“image-n:

Mszp

�</text>
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                    <text>January I6, I969
Dr. Gabrlol K. Rubin
98-50 67th Avenue
Pores? Hllls, New York ll374
Dear Dr. Rubln:

If

was kind

of

you

to call

me The

other day.

you have coaplofod a survey of your pOpulaflon
be pleased To hear from you.

I

when

would

In tho moantlmo, onclosod Is a profoool of on ongoing
sfudy uhlch may be useful as a model.
Good luck!

Slnooroly yours,
Fink, M.D.
Professor of Psychlafry
Hex
MFskp

�</text>
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                    <text>January

l6.

1969

Dr. Carl Salzman

Psychopharmacology Research Branch
National Institutes of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 200l5
Bear Carl,
Enclosed are the Form 225 for each study that
RPR form for each study now in progress.

and the

is completed.

indicated

As I

earlier letter. the studies of qyclazocine, naloxone.
ketimipramine and doxepin in clinic populations are continuing.
in

RPR

my

forms

will

be submitted as soon as thuse

studies are completed.

studies I have listed our unilateral ECT
since
is on the its analysis. If this does
emphasis
study
not fit your books. just return the form.
Under the new

I have

written separately with regard to the June
Sincerely yours,

7:
v
v
-—.

Max

Fink. M.D.

Professor of Psychiatry

Wmnzsm&lt;m:Wp-vmv:

Mszp
Ame-"x:

»

«

sum-mu»:-

5

meeting.

�</text>
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                    <text>January l6.

1969

Br. Carl Salzman
PsychOpharmacology Research Branch
National Institutes of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland ZOOlS
Gear Carl:
Thank you for the invitation for the June 5 ECDEU
meeting in Bethesda. I would be pleased to participate
in the panel discussion on fluphenazine enanthate. To
the extent possible, perhaps the panel should be broadened
to include fluphenazine decanoate as well. since these
two long—acting forms have many

things in

common.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

“rt:

,
,
-

,
jimmy”;

”

—

A

.3....,_.

V

M.

iﬁiw4,_.,

\

.3

an

sa
\

)

�</text>
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                    <text>January l8, I969
Dr. Marlin H. Keeler
The Universlfy of North Carolina
School of Medicine
Doparfmon? of Psychlafry
Chapel Hill, North Carolina
Dear Marlin:
l

#0 a

on

glad'lhal

visit

you will be Joining us and look forward
in the next few months.

Enclosed is a check for $263.00 which should cover

fhe oxponses for The visit of October l0 and December 5,
as wall as an honorarium for October l0.
Sincerely yours,
Max Fink, M.D.
Professor of Psychiafry

MF:kp

�</text>
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                    <text>January
ﬁr. John

22 , 1969

J. Bellini

Director, meeau of Narcotic Control
855

Central Avenue

Albany,

New

York 12206

Dear Mr. Bellizzi:
Enclosed

is

an

affidavit mega-ding the supplies of
my office at

depreaaant and stimulatory drugs in

39 Arleigﬁ‘x Road, Great Neck, New York.

position at New York I'i‘edical College , however,
we do have supplies of opiates and marijuana for our
experimcmtal purposes . If the mmlatims require an
inventory of these (huge; , please Wicate the requiremzmtc .
In

“c.”

m-

w-grw

my

wrei-

Sinccnoly yours

,3.“ng

3

ai"

-

”Kr-‘1'!”

5

Max

w
.A

v

:r-v-a;

wan-m-

5-;

r

n:.
L.-

:-

rgrgxfl‘l."

,
u

-H

,
&lt;

I;
«cum

unto-y

mar:-

Fm

0,

NJ).

Professor of Psychiatry

5-»

2‘1?sz

�</text>
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                  <elementText elementTextId="105722">
                    <text>January 22, 1969
Dr. Joyce: Small

lame Carter Hospital

Indianapolis, Indian

DearJoyoe,

Indmddngﬂmghsom ofxrymtee, Ifindthat

Ihadprouﬁsedyoaendymapreprint Imgretthe
delay, but enclomd are two oral-mints demibing our
prawn: View of drug classification using EEG criteria.
One report is from the Armani Rewlw 05 Phamacotow

and another, a mom pomlar version, from a forthcomng,
book ”D1133 and the Brain.

__

IoouldmtmakeSmamsinJmmy,buthopethat

IcandosoattheCentmlEﬂSmtingainMardm. Is
possible for you to send me a mpy of the program and
any other data regarding motels?
My

it

.4.

,,-_..;.‘r,.

'M..;

‘

best regards.
Sincerely yams
ﬂax Fink, M.D.

_.

Professor of Psychiatry

”79¢

‘

�</text>
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                    <text>ﬁvw—

m‘TVWW,a-wmm W

.

n

,i‘.

v

7,“ ,__,

,

.‘..,,U_.

,7

WW

_/

a“

A.

~

.

Hawsrqu-m—_d r-r.‘ --../~

var—1......” ‘Ivuwvf‘v-"W’Y"w

mun-JW‘V

our." WF—Vva—l—

January 22, 1969
Dr. Joseph Wortis
Department of Psychiatry

Mamnides Hospital

3

é
u

I+802 Tenth Avenue
New York, New York

11219

rurzm‘r-NW‘V"

.

"WWW

Dear Joe,

I am pleased to submit the report ”Puerperal Schizophrenia,
Physiological Interaction Between Mother and Fetus” by Drs . Taylor
and Levine for your consideration for the first issue of Biological

A
—-;'—“W’

u

"‘qux

-r
‘-

Wm

P45

ychéauy.

I hope that the work of these two young men , which has been
of particular interest to ‘Al and nyself can appear in your first
issue, as I think this material is both timely, significant,
and particularly related to the message presented by our former
president , Hudson Hoagland.
Good

rV

luck in the journal.

an”

Sincerely yours ,

mum

nov-

Fink, MJ).
Professor of Psychiatry

Max

TNWF-"I‘I‘V'.

NF :kp
nxmmu-v—wrv

W”;

W

. ,

w

~

�</text>
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                    <text>.

:—

c-y.

a

r »-...,:-.....,s.

..,x..._..,W~,.H,

January 22, l969
Dr. Philip A. Boyer, Jr.
Meoical Director
Marion Laboratories, Inc.
ioaau Bunker Ridge Road
Kansas tity, Hissoori 64l37

hear hr. boyer.

‘

Thank you very much for the reprints describing studies
of orugs in hyperkinetic children. I-did find the articles
interesting and have sent them to ”W associate, Dr. SimeOn.

subject of
is unclear.
A few years ago we die administer papaverine in single doses
and were able to show changes in the ttG at a tine when
peripheral blood pressure was altered. This study did not
provide enough data to assure us of the central effects of
papaverine. There have been nuncrous studies of the effect
effects of vasooilators
increasing interest, but one for
The

on EEG

is

a

which the oata

of carbon dioxioe on ttﬁ, but these were done primarily using
visual analysis and here too the data is unsatisfactory.

investigator, John Whittier, has been interested
effects with vasodilators but his techniques are
in the
and
his studies should be replicated.
limited
The substance of these remarks is to indicate that while
the demonstration of EEG effects of vasodilators is not complete,
I believe that vasooilators will effect the Etc and that
quantitative methods could describe the changes.
Again, aw thanks for the reprints.
one

EEG

Sincerely‘yours,

Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>January 25, 1969
Dr. Edgar Grunewald
Geigy Pharmaceuticals

Ardsley,
Dear

New

York ldbdz

to,

Following your request, we have reviewed our ongoing
ketimipramine~ieipramine study. This second phase was under»
taken to compare the two compounds in a random assignnent,
blind basis following the peeliminary study (Sunnery II: 8-30-65)
and the protocol (3—20—63). The study began in April lees.
To date, 26 patients in the outapatient population of the
Metropolitan Hospital Community Mental Health Center satisfied
the criterion for admission to the study of exhibiting symptoms
of depression, retardation and endogenous features. Of these,
6 are classifieo as psychotic depressions; l7 as neurotic
depressions and 3 as schizo~affective disorders with depressive
symptoms. Fourteen patients were assigned to imipramine and l2
to ketimipramine. Twelve are in progress now.
Of l4 subjects, 6 completed the study period and a were

twaa—nv

:
L

,

incomplete (“drop—out“). The “drop~outs“ were with both drugs
to drug factors. 0f 3 ketimipramine
treated patients each improved and were discharged from the

and appear unrelated

clinic.
after 5

One

of the

drop—out

patients discontinued treatment

weeks therapy, and we have not been able to obtain a
follow—up. At her last visit, her symptoms were ameliorated.

'

Three patients completed the imipramine
much improved (2) and improved (l);

rated as

trial,

being

Secondary effects were few (excluoiny the possibility that
sone patients failed to return because of symptoms assuneo to
be drug related). hith imipramine, headaches and “burning, red
eyes“ (l) and nausea (l) were reported. With ketimipramine,

‘

�January 25, 1969
Dr. Edgar Grunewald
Geigy Pharmaceuticals

Ardsley,
Dear

New

York ldbdz

to,

Following your request, we have reviewed our ongoing
ketimipramine~ieipramine study. This second phase was under»
taken to compare the two compounds in a random assignnent,
blind basis following the peeliminary study (Sunnery II: 8-30-65)
and the protocol (3—20—63). The study began in April lees.
To date, 26 patients in the outapatient population of the
Metropolitan Hospital Community Mental Health Center satisfied
the criterion for admission to the study of exhibiting symptoms
of depression, retardation and endogenous features. Of these,
6 are classifieo as psychotic depressions; l7 as neurotic
depressions and 3 as schizo~affective disorders with depressive
symptoms. Fourteen patients were assigned to imipramine and l2
to ketimipramine. Twelve are in progress now.
Of l4 subjects, 6 completed the study period and a were

twaa—nv

:
L

,

incomplete (“drop—out“). The “drop~outs“ were with both drugs
to drug factors. 0f 3 ketimipramine
treated patients each improved and were discharged from the

and appear unrelated

clinic.
after 5

One

of the

drop—out

patients discontinued treatment

weeks therapy, and we have not been able to obtain a
follow—up. At her last visit, her symptoms were ameliorated.

'

Three patients completed the imipramine
much improved (2) and improved (l);

rated as

trial,

being

Secondary effects were few (excluoiny the possibility that
sone patients failed to return because of symptoms assuneo to
be drug related). hith imipramine, headaches and “burning, red
eyes“ (l) and nausea (l) were reported. With ketimipramine,

‘

�</text>
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                    <text>January 27, l969
Dr. Hudson Hoagland
The Worcester Foundation

for

Experimental Biology
Shrewsbury, Massachusetts 0l545
Dear Hudson.

of our resident physicians. in following a clue
described
by Shearer et al., developed some
recently
”novel" ideas about the schizophrenic process. These
concepts are based on presumed hormonal effects. As no
one here is qualified to review these critically, we are
enclosing a draft summary. I would be most grateful if you
could review the data and provide a candid opinion as to
Two

its merits.
like

In the event the material has some merit,

an opportunity
Many

we

would

to discuss the next logical steps.

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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              <elementText elementTextId="36942">
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              <elementText elementTextId="36943">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                <elementTextContainer>
                  <elementText elementTextId="102795">
                    <text>January 27, 1969
Dr. S. Carson

Food and Drug Research

58th Street and Maurice
Maspeth, New York ll378

Laboratories
'

Dear Dr. Carson:

Separately

we

for cyclazocine

are sending all the data available to

and naloxone. Three reports have been
from this laboratory and they are included as
published
wel
.
us

I would appreciate your calling me after you have had
a chance to read as much as may be pertinent to the question

of the potential solubility of each of these compounds in
silastic. so that we can arrange to discuss our interests.
Please feel free to xerox as

would appreciate the return of
you come to visit us.

much as you wish

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

but

all of the information

I
when

�</text>
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              <elementText elementTextId="36930">
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            </elementTextContainer>
          </element>
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            <elementTextContainer>
              <elementText elementTextId="36931">
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            </elementTextContainer>
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            <elementTextContainer>
              <elementText elementTextId="36932">
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              <elementText elementTextId="36933">
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                  <elementText elementTextId="102794">
                    <text>January 29, i969
Miss Sfany Cuesia

lSl

Philadelphia
Dear Miss Cuesfa.
Thank you for iha spacial search, a copy of which is enclosed.
This search eiicifed game addifional arflclas of lnferesf in the
drug field, bu+ none additional for compufers and neurophysiology.
The addlflonal items from fhe drug liferalurn are welcome. The

addlflonai articlns ragarding digilai computers alone are ’mlsses'
insofar as The field of digifal compufars is very large and fhe
usefulness of fhe service would be abridgod if all were recalled,
including The many +ha+ are of inferesl +0 phases oufside my interesf.
nof sure wha? +he difference in logic is among ihe
various fypes of quesflons. The ifems of inferes? are fhosn fhaf
i

include:

am

Drugs/man

Drugs/EEG (neurophysiology/man

Drugs/ all subtypes of psychoactive
EEG/compufer/digifai
Brain/compufer digital

Brain/drugs
I

appreclale your afforfs on

my

behalf. Thank you.

Sincerely yours,

Max

Fink,

M.D.

�</text>
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                    <text>January 31, 1969
Dr. Alain Sanseigne
Squibb Intarnational
ﬂew York City
Dear Alaina,

It was kind of yau to sand as the translation of the
Lumbart/Midenct report, which I have read with interest, and with some'
disappointmant. The concepts are good, bit as you know already, thare
is

no data and while

I

impressed. I fear that

am

not be stimulated to look into

this ptoblam.

my

colleagues will

studies, however, shculd do much to revive interest in
the high dose problem, and I look forward to hearing of your results.
Your

that I write

will

be pleased to know that Charles Shagaaa has aakad
a short chapter on tha longwacting fluphenazines for a

You

clinical
justics 1t antics.

forthcoming review of advance» in psychopharmscology in

I hope-that I will

practice.

Yaur

lunch soon

3

My

asaiatant

do the subject tbs

sounded deliciouu over the telephone. Roé.about

best ragards.
Sincerhly yours,

Max

Fink,

M.D.

�</text>
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                    <text>‘ﬁw:,yv'maw1ulﬁ

v-m.

--

‘IA-«rra'mw

w...

A

ww

'"an

w,

,

V’iwmmnw-m

.
__,_n

January 31. 1969

r

.

new-mm

vr-

"‘VIW'JJV'E'

I'M!"

_

Dr. Max Schnack

Department of Clinical Pharmacology
Geigy Pharmaceuticals
Ardsley, New York 10502
Dear Dr. Schneck:

-g"mv-wr-,¢V,.u.,,m.

Ir—r“

"‘

I

It

‘1‘lfiﬂ’i'vo‘vWFVWEM-rrmix-Err

"n”:

""“‘""‘"“3"-

r1:

"a"???

Yaw-CV.

[WIFE

you about IPA 2443.
when
some evidence of
from you

chatting with

would be pleased to hear

its antinarcotic activity in

animals has been accumulated.

Enclosed is a summary of the EEG classification data
as well as two reports describing the specific application

to cyclazocine.
Thank you

for bringing this problem to

my

attention.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.
r.

WW'W'JN‘aw-r

was a pleasure

ﬁFskp

�</text>
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                    <text>January 31, 1969

unnu-

“35.1w."-

YA-"chev"‘!w,

0-0.2”:

mump

Dr. William P. Blackmore
Director, Clinical Pharmacology
Sterling—WinthrOp Research Institute
Reusaelacr, New York 12144
Dear Dr. Blackmore:

is in reply to your letter of January 27, reatating
your intention to withdraw the Sterling-Winthrop IND for
cyclazocine as an anti—depressant.
This

Studies of cyclazocino as an anti-depressant were
concluded in the spring of 1968 and a summary submitted to
Dr. Joseph Bird. No additional patients have been treated
with cyclazocine as a potential anti—depressant since that
summary was completed.
qu-‘e:

_.

_-..&lt;

-

"WW,

man:

The remaining supplies of cyclazocine that we used in
the treatment of depression were transfered to our narcotic
addiction treatment evaluation program and have been used in

that program.

Sincerely yours,

”,ua'uktvmrd:

(:2?!

r:

.

:A
#4:

Fink, M.D.
Professor of Psychiatry

Max

W713M72

“37:1,!

:-

“Hagggmgm

iii-721".

MF:kp

�</text>
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