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                    <text>..

“n.7,,

,_

,
,v

.7...”

”w

.
J...

WWMWM,

q...

.

«ﬁn.

December 20. l967
rum-v—w—rﬁm'.

Dr. William Karliner-

Franklin Rodd
Scarsdale, New York
20

s’vryvp...—

www.my—m—V

:

..

.x-

AFTIW

'.'V‘-—U~ww-VII"

Bill,

Dear

Miss Harriet Bernstein, age 39, was seen at Gracie Square
Hospital on December 9 and in our EEG laboratory on December l9.
At Gracie Square she presented a mild organic mental syndrome,
moderate to severe depressive state and evidence of barbiturate
intake. She was mildly ataxic, labile and her Speech was slurred.

5-1

min—va-"mw‘

when seen on December l9, she was no longer ataxic nor did
she have nystagmus. The mental syndrome had been relieved and
she appeared anxious. tense and depressed. She had a pressure
of speech.
The electroencephalogram (#039) was symmetric without evidence
of a focus. The rhythms were highly irregular with mixed theta,
alpha and a moderate degree of high voltage beta activity. The
beta activity did not appear in-spindles or runs. The frequency
of theta activity was 5-6 cycles per second, with amplitudes between
40 and 80 microvolts. The record was filled with eye blinks
artefacts despite manual control.

hyperventilation was repeated three times and on the first
she exhibited a two Second burst of 200~250-microvolts.

trials

two

activity. with spikes.

These were symmetric and occurred
In the succeeding twenty
seconds there were random S~6 cps higher voltage (100 uv) runs.

.5

cps

after

80 seconds of

hyperventilation.

This record gives evidence of continuous, generalized cerebral

dysfunction.

The

presence of spike and

is consistent with cerebral dysrhythmia.

wave

bursts

on

hyperventilation

Recommendation: In view of the history, we cannot exclude
the possibility that the dysrhthmia is related to previous convulsive
treatment, although the probability is Very small. With this in
.mind I would suggest that she be continued on Oilantin treatment
and that the depressive state he treated with imipramine. If imipramine
is given rapidly in the hospital setting, we will know if dysrhythmia
is enhanced.,if the EEG is repeated when she is stabilized at your
.

average imipramine dose.
Thank you for the opportunity.25chee/7i7ﬂxoSee7ﬂdrV’
'

SinCerely yours,

Fink, M.D.
Professor of Psychiatry

Max
.

Mszp

.

�</text>
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                  <elementText elementTextId="102391">
                    <text>—.

v1

'w'..‘~"vvr\\.uvi

n '.\,«.~"\v.-

,~

n -.--..v~.-w~~,~.;$

;~.v.m~-.rv~.~

K"

a

,

—

nr.rv' nr'owvn

saw wum—x-wum—csr

.w-w

.v.

.v

.7,

mu“

.m

_..‘-.

V..-

_,.7nu

December 20, 1967
Dr. Joseph 6. Bird

Sterling-Winthrop Research Institute
Rensselaer. New York 12144
Dear Joe.
on

The meetings in Puerto Rico were
cyclazocine was well received.

excellent

and the

report

Dr. Cole did discuss his problems with me one I recognized
the difficulties he faces in trying to develop a new program.
I have read
My

the

new

protocol and

best wishes for the

New

it

is satisfactory.

Year.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Hszp

�</text>
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                    <text>v-w

w;

wean-m-umwm

wwa—vr'w

w-

”my

'W'Yiﬂmw-i

.....

,

December 19. 1967
Dr. Antoine Remand
47 Blvd. de L'Hooital

Paris 13, France
Dear Dr. Remand:

I have Just received and read the October l967 issue of
I find this newsletter of great interest and would
Igggg.
encourage you to continue making this newsletter available

to the

My

EEG

membership.

best wishes for

a Healthy and Happy

New

Year.

Sincerely yours.
Fink, M.O.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>December 19, l967
Dr. A.

Cerletti

Eiological and Research Division
Sandoz Ltd.

Basle, Switzerland
Dear Dr.

Cerletti:

Enclosed is an abstract for your consideration for the
forthcoming meeting of the GIMP in Spain. This abstract
reflects recent studies in our Department testing a variety
of theoretical models in the treatment of narcotic addiction.
The report is related to the sessions describing the pharmacological
and clinical criteria of drug selection.
Thank you

for your consideration.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>Gecember

l9,

1967

Dr. Henry Brill
Vice Chairman
New

York

State Narcotic Addiction

Control Commission

1855 Broadway

New

York, ﬂew York l0023

Dear Henry.
I was

pleased to have you

visit the

Department yesterday

for your patience in listening to our
experiences with naloxone. Enclosed is a copy of the letter
which I recently received regarding the laboratory tests.
and want to thank you

Your assistance in making this interesting compound
available for further study will be appreciated.
'

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>December

l9, l967

Dr. William R. Tabor
Robins Company

A. H.

1407 Cummings Drive

Richmond, Virginia 23220
Dear

Bill,

Thank you for the forms and the protocol for our demonstra~
tion with medical students at the new York Medical College. I

have signed the forms in the appropriate places and believe I
have answered all the open questions.
The

for

pharmacist here will prepare the amobarbital.

Thank you once again
a Happy New Year.

for your cooperation,

and

my

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

,

best wishes

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                  <elementText elementTextId="102395">
                    <text>H. «my

a.

..\

.

,,

.

.-

.

..‘_4.p_vn,‘.u.»‘—_

om- 1177.15. ,Y-.. n.

v

“Vammna...;‘_ivs-,.s—v~~x,‘.\_,

“Thumb“, ”r

V.,._1,,..,

.

.

December

air. Si lverman

York State Bureau of
270 Hedison Avenue
New York, new York
New

.

,

,.

1

»

«wuwwq

”.3, “1 "w, (Wyn-:3»

”a”! a “my--

rajhmj-J‘”

w.rp.——WW.—V1W 1'11—

l9, l967

narcotic Control

Dear Mr. Silverman:

received a letter from George M. Balk, District
Supervisor of the Bureau of Narcotics, Treasury Department,
with reference to an application for registration under the
Marijuana Tax Act. In his letter, Mr.'8elk indicates that
prior to approval of this application for registration in
Class 5. we must comply with the New York State Law concerning
research utilizing marijuana.
I have

A

copy of our

original request to the

narcotics is enclosed.

Commissioner of

indicate the steps necessary to
State Law?

would you please

with the

New

York

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Nszp

comply

�</text>
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                    <text>H. «my

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December

air. Si lverman

York State Bureau of
270 Hedison Avenue
New York, new York
New

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l9, l967

narcotic Control

Dear Mr. Silverman:

received a letter from George M. Balk, District
Supervisor of the Bureau of Narcotics, Treasury Department,
with reference to an application for registration under the
Marijuana Tax Act. In his letter, Mr.'8elk indicates that
prior to approval of this application for registration in
Class 5. we must comply with the New York State Law concerning
research utilizing marijuana.
I have

A

copy of our

original request to the

narcotics is enclosed.

Commissioner of

indicate the steps necessary to
State Law?

would you please

with the

New

York

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Nszp

comply

�</text>
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                    <text>December
Dr. Marion

l9,

1967

J. Finkel

Director. Divisiontbf Metabolism

and Edocrine Drugs
Bureau of Medicine
Food and Drug Administration
Washington. D.C. 20204
um

,~

Dear Dr. Finkel:

mfg—wm-wwmrr

for your letter of December 13, 1967.
pleased to accept your invitation to participate in the
Fireside Conferences on May 3, in Atlantic City.
I am

m:.,mvm—nru

Thank you very much

I look forward
.

to seeing you.
Sincerely yours,
Fink, M.D._
Professor of Psychiatry

Max

HF:kp

�</text>
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                  <elementText elementTextId="102398">
                    <text>.‘u.

7“,. wwn—QWW...‘

F‘W.¢~w.ﬂ

».

.

_

V

,

‘1’

gm;

,

,

_

,

,

,'

-

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-\~

can,

van-rum“

.

27w,“

«1».er uwauwwmuwununw—m—w

-xr4""‘*

-&gt;

K’VW‘rVarrn-ﬂ‘

December 13, 1967
Dr. A. Arthur Sugerman

Chief, Investigative Psychiatry Section
c/o New Jersey Neuro~Psychiatric Institute

Box

1000

Princteon,

New

Jersey 08540

Bear Arthur.
Both Don and I have January 12

Princeton.
I

look forward to seeing you

set aside for

at the

a

visit to

ACHP.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="102399">
                    <text>December

l3. l967

Dr. Tito B. Dinzcy
Downey Veterans Administration Hospital

Denney, North Chicago,

Illinois

60064

Dear Dr. Dinzcy:
Thank you very much

for your letter.

I am indeed

interested

in the appointment of another internist to our Department. I am
enclosing a set of forms which will give me a better idea of your
background and experience. I would be grateful if you would complete
these and return them to me promptly.
Thank you

for your interest.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kp

enc.

�</text>
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                  <elementText elementTextId="102400">
                    <text>Whv,'vr -u.,-- F'T‘f"-m&gt;

i‘l?ﬁn-‘k~ﬂo.'l'v“ﬂ"“‘w

‘

,

‘

.

m «m

-

'

\

,

.

1

,

528

haw

..

“*mmmmu"

wws-‘5‘um ,

v

_

,.

'

’4

»

Ceiumbia
.

a

4
.

,

hrs, Green:'

Dear

'

,

.

-.

hehartin strut
Westminster. British

Canada

WV

.

i3, i?§7

'HVQecémber

Hrs.-Eva Graen

'v

ef'a raport which has recentiy
which éescribes the present status’
and
'appeared in the gggnhzg,
Enciosea

=

is

a

preprﬁht

.

of cyciazocine treatment. In addition, I am taking the iiberty
of enclosing a preprint of another,report which describes the
ganerai phi osophy bf antaQOhiSts in the treatment of narcotic
addiction somewhat more fully, titheugh it is baseﬁ on the same
data.
Cyclazhcine is an experimehtai compound and is not available
except in research canters. It is given both orally and parenteraiiy.
The dasages are indicateﬁ‘ih the report. At the present time
‘cyciazocine has nﬁt bash approved by the Food ané Drug hdministrao
tion of the United States.
In the event that-réspOnsibie medical Officés are interested
in expioring.the additional uses of this compnund please ask them
"
to write to ma.
-

'

'

»

‘

'

'

'

i

V

‘

.

Sincereiyybursi'
‘hax Fink,

h.a.

‘

Professor of Psychiatry

cg: tipDr. Ernest

Tang

12 Hubbard Parkr

~

‘

'

Cambridge, Hassachusdtts 02138

f
Dear Ernie,
_
Mrs.
Green to me. 'As you can tell
Thank you for referring
from the heading of_this stationery; I left St. Louis in June 1966
and hava been most active in the study programsiin New-York. I
,hava established a laboratory for EEG and human psychopharmacoiogy.
Our interest'is in the affects of psychotropic drugs 0n behavior
and the work with nardotic addicts is but one facet of the broad
&gt;

spectrum of treatment of the mentaiiy.

""""

"",.w

,_,

�</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="31383">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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  <item itemId="3139" public="1" featured="0">
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                  <elementText elementTextId="102401">
                    <text>December
Mr.

W.

H.

l3,

1967

Bold

Clinical Research Associates
Squibb Institute for Medical Research

Manager,

Brunswick,

New

New

Jersey 08903

Dear Hr. Bold:

It

pleasure having you and Mr. Gaglione visit with
as on Friday. As you requested, a copy of the summary statement prepared by my staff is enclosed.

that

The
we

was a

project is going well,

are planning to have a

to the full

at

12:15pm.

staff of the

present supplies
cooperation.
Our

and I

am

pleased to

tell

Department on Friday, February 2,
seem

adequate. Thank you br your
Sincerely yours,

Fink, M.B.
Professor of Psychiatry

Hex

HF:kp

you

presentation of this material

�</text>
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          </element>
          <element elementId="41">
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              <elementText elementTextId="31392">
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            <elementTextContainer>
              <elementText elementTextId="97024">
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      <tag tagId="4">
        <name>Correspondence</name>
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  </item>
  <item itemId="3140" public="1" featured="0">
    <fileContainer>
      <file fileId="1776">
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                <name>Text</name>
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                <elementTextContainer>
                  <elementText elementTextId="102402">
                    <text>1.“... ,

Mwmnv. “.— «mu-rp— a.-...y-uu

,

arm“

W'-7-(I' 'w

December 13, 1967

Br. Richard P. White

Associate Professor of Pharmacology
The University of Tennessee

Memphis. Tennessee 38103
Dear Dick,
These

last

few weeks have been overwhelming, as I

tried

to complete a number of reports for the ACNP Meetings. 1 do
not know if you plan to be there. but if you are, then this
letter will be redone. If not, perhaps it answers some of
the questions you recently posed.

In general the Program Committee of the Society of Biological
Psychiatry wishes the abstract to be short so that
can be
puslished. The abstract which you sent me is quite satisfactory
and I think you ought to send
in.

it

‘

it

I

m;

will call

you

later

in the week. as soon as this hectic

period is over. to discuss with you the status of our project.

u,

7"

fey
"who—1"».

v
.

best regards.
Sincerely yours,

r
...

WW1)

AnWﬂ

Fink, H.U.
Professor of Psychiatry

m

Max

-

W
.

n...—

w-

.,_

yfr—IWL-‘WW

ﬂ

»
.

mmvl"

.

mm-..“

rwwwwuwme‘v-VJ

Mszp

�</text>
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                    <text>December
Dr. Joseph 6. Bird

l3, l967

'
»

Sterling-Ninthrop Research Institute
Rensselaer. New York l2l44
.

Dear Joe,

After submitting the various preposals to the Research

Committee of the Medical College, I find

grantor's agreement

that

one form, a

not submitted. We would be grateful
if you, or another responsible officer of the Sterling»
Winthrop Research Institute would approve the agreement.
enclosed Ind return it to’mes
was

-

.

The
who have
minimum.

first

depression_study has an additional ten cases
received cyclazocine for a period of four weeks
I have asked Br. Simeon'ahd 8r, Zaks to summarize
the status of the patients as of mid-December-and we will
write a formal report during the first weeks of January.
With this group of patients we found that the dosage schedule
suggested in the proposed comparative study is a suitable one.
As

are
study.

made
Hy

soon as the supplies of oyélazocine and imipramine

available,

we

are prepared to undertake the comparative
‘

best regards.
-Sincerely yours,

-

Max

Fink;‘M.D.

Professor of Psychiatry

MF:kp

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                    <text>December
Dr. Joseph 6. Bird

l3, l967

'
»

Sterling-Ninthrop Research Institute
Rensselaer. New York l2l44
.

Dear Joe,

After submitting the various preposals to the Research

Committee of the Medical College, I find

grantor's agreement

that

one form, a

not submitted. We would be grateful
if you, or another responsible officer of the Sterling»
Winthrop Research Institute would approve the agreement.
enclosed Ind return it to’mes
was

-

.

The
who have
minimum.

first

depression_study has an additional ten cases
received cyclazocine for a period of four weeks
I have asked Br. Simeon'ahd 8r, Zaks to summarize
the status of the patients as of mid-December-and we will
write a formal report during the first weeks of January.
With this group of patients we found that the dosage schedule
suggested in the proposed comparative study is a suitable one.
As

are
study.

made
Hy

soon as the supplies of oyélazocine and imipramine

available,

we

are prepared to undertake the comparative
‘

best regards.
-Sincerely yours,

-

Max

Fink;‘M.D.

Professor of Psychiatry

MF:kp

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                    <text>[1W

,,v”

“rum-W w vemwuwr...

”mm

was.-m..nw,.m—.m-...~1., MW” .., .e-ww.r.r,-.,mww...“we»-.~.«.-rv.--..~.c~~.vvmem-mwwm-vww-«avw WV-Vmw-aw—

December

L

{

:

;

i

?

‘=

Dr.

Ju’orein

New

York

Associ 'rofessor of
550
New

Dear

First

l3, l967

Neurology

University School of Medicine

York,

Avenue
New York lOOl6

Juli,

Thank you very much for the contour maps of EEG spectra.
Both Don and I found them quite interesting. In some ways,
they are similar to the reports presented from UCLA. However,
the possibility that relationships can be discerned in the bi—
spectra which are ., obvious in the usual spectral pictures
makes this tool
interesting one and we look forward to
the further deve .. ent of this program.
‘

sleep figure is probably the most
I hav~
having looked at many sleep figures,
. ed
important.*ver,
so little in this field that I do not know how to comp - end
the figure you present. Is it possible that in the future a
single drug effect may be represented? If one could look at
the effect of a common compound like a barbiturate or the
intravenous administration of chlorpromazine,
it
would communicate much more to people like mysel
thigfi&gt;think
The

deSpite

my

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬂfﬂt

W’ WZWW

L"

�</text>
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                    <text>"Wm—wwurvmmw»

v

ww'—~'rw~w-wnv

.

,

.

ww-

'

,

December

l3.

1967

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New York, New York

Sear Alain,
I have been asked by the Separtment's Chariman to present
of our findings in our new drug studies to the full
department staff on Friday, February 2. I have decided to present
the Prolixin decanoate and enanthate material. I would be pleased
some

if

you would be a

discussant.

I am also preparing some lectures for the residents and as
this will take place on Friday from ll to 12, I should like to
ask you to participate with me that day at ll o'clock.
The
‘

i

My

staff conference is
best wishes for

from 12:15pm

a Happy

New

to 2:00

pm.

Year.

Sincerely yours,

E

Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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              <elementText elementTextId="31442">
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              <elementText elementTextId="31443">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>"v

4;:

neon:

I

.l.‘

.L

~»

or

",7.

.
.,

"um",

December 13, l967
Dr. Michael C. Barry
Medical Director

Assistant

white Laboratories, Inc.
Kehilworth; New York 07033
Dear Dr. Barry:

I have arranged for the concentrated Permitil to be
tested in Istanbul by Dr. Necmettin Polvan. He has just
written to me that the form is agreeable. I would be
grateful if White Laboratories would supply us with a
similar concentrate of approximately lGDmg/cc. If we plan
to treat 40 patients for a 3 month period, I estimate that
we will need 360 grams.
I would

like to file the necessary

ask your help and advice as to
Thank you

how

FDA

forms and would

to go about this.

for your cooperation.
Sincerely yours,
'

Fink, M.ﬂ.
Professor of psychiatry

Max

.L

L

t
.

w.

,

MF:kp
..

«It»

.

F

an

on".

L.

_.

u...~..~I-I-o

L-

�</text>
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              <elementText elementTextId="31453">
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                    <text>0%
December

l3.

1967

Mrs. Eva Green
528

New

hehartin Street

Westminster, British Columbia

Canada
Dear

hrs. Green:

Enclosed is a preprint of a report which has recently
appeared in the QJAJLA. and which describes the present status

of cyclazocine treatment. In addition, I am taking the liberty
of enclosing a preprint of another report which describes the
general philosOphy of antagonists in the treatment of narcotic
somewhat more fully, although it is based on the same
addiction
ate.
Cyclazocine is an experimental compound and is not available
except in research centers. It is given both orally and parenterally.
The dosages are indicated in the report. At the present time
cyclazocine has not been approved by the Food and Drug Administra~
tion of the United States.

that responsible medical offices are interested
additional
uses of this compound please ask them
in exploring the
to write to me.
In the event

Sincerely yours,
Max

Fink, H.U.

Professor of Psychiatry

Mszp
cc:

Dr. Ernest Taves
12 Hubbard Park
Cambridge, Massachusetts 02l38

Dear Ernie,

for referring Mrs. Green to me. As you can tell
from the heading of this stationery, I left St. Louis in June l966
and have been most active in the study programsiin New York. I
have established a laboratory for EEG and human psychopharmacology.
Our interest is in the effects of psychotropic drugs on behavior
and the work with narcotic addicts is but one facet of the broad
Thank you

Spectrum of treatment of the mentally.

�</text>
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                    <text>December

ll,

l967

Marion d. Finkel, M.D.
l900 South Eads Street

Arlington, Virginia

22202

Dear Dr. Finkel:

Enclosed is the original and four xerox copies of an
abstract entitled 9Narcotic Antagonists in the Treatment of
Opiate Dependence." for your consideration for the Fifth Annual

ieeting of the American College of Clinical Pharmacology and

Chemotherapy.

-

All the authors of this report are from the Department
of Psychiatry, New York Medical College. Both Dr. Fink and
Freemnan are Professors of Psychiatry, Dr. Sharoff is Associate
Professor and Dr. Zaks is ReSident Psychiatrist.
All correspondence should be directed to

offices at
I

5

East lOan Street,

new

York,

New

me

at the Department

York l0029.

trust this abstract is of interest.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>December 4, 1967
Box X8503

York Times

New
New

York, New York

Sir:

Dear

past year we have established a number of
research
clinical
programs focussed on understanding the
on brain function and behavior.
of
drug
treatment
impact
During the

Primary emphasis has been placed on patients in our Mental

health Clinic who are
psychotropic drugs.

now

receiving

a

variety of

new

parallel program, we are establishing an evaluation
of convulsive therapies utilizing some of the more advanced
quantitative techniques for estimating changes in brain
In a

function and behavior.

for
me

for

‘

;

In both these programs we are now considering
full time staff members.

If this opportunity interests you,

a copy

of your curriculum vitae

an appointment.

and

applications

wbuld you please send

call

my

office (369-7900)

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>:w- nu-.:.—rqny;-ﬂ

December

l,

1967

Dr. Werner P. Koelle

Senior Scientist
The worcester Foundation for Experimental Biology
Shrewsbury, Massachusetts 0l545
Dear Werner,

citation in the article “Effect
Diethazine
on EEG and Behavior:
of Anticholinergic Agent,
Convulsive
of
Therapy" the year is
Significance for Theory
With reference to the

l958.

I look forward

to seeing you in Puerto Rico.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

.

way,” -,

“g

�</text>
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                    <text>'EIW,-v1'vv‘.wr&lt;r

A

March 28. l968

Dr. Arnold G. Blumberg
m.

.

mm.

47

1'9!

Department of Medicine

Hillside Hospital

P. 0. Box 39
Glen Oaks, New York

&lt;2

’IIW'Dzv-gyl‘

Dear Arnold,

to read of the death of your mother. It
years since I last spoke to her but I
few
remember from the
visits to your home during our early
days on Long Island. Please accept my sympathy.

I was saddened
has been many, many

the unusual opportunity to discuss the report
“Enhancement of Imipramine Antidepressant Activity by Thyroid
Hormone“ at the forthcoming meeting of the APA. I know that
you could do this much better than I, and am taking the
sent to me by Dr. Prange,
liberty of enclosing the pre-print few
minutes to read it and
have
would
a
in the hope that you
to cement.
I have

thyroid extract been used to
convulsive therapy?
Has

alter the resoonse to

Have you,

or anyone else, attempted to confirm Dr. Prange's

Thank you

for your help.

suggestion?

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>w.“

_,

we...

c
j."

.
,—

awn-.7

1.,

v:

March 28, 1968

Dr. Stephen A. Weinstein

Laboeatory of Behavioral Physiology
Johns Jopkins University

Baltimore, Maryland 21205
Dear Dr. Neinstein:

have read your letter to Science, describing theCommunications in Behavioral Biology. This reporting
system is of interest to us and I would be grateful for
any information regarding participation which may be
I

available. Is this system in operation

now?

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>March 28, l968

Dr. Arthur

J. Prange. Jr.

Department of Psychiatry

University of North Carolina
School of Medicine
Chapel Hill, north Caroline
Dear Dr. Prange:

for your paper “Enhancement of Imipremine
by
Thyroid Hormone." I have read this
Antidepressant Activity
with interest and can find little that I can criticize. The date
Thank you very much

is impressive.

may be of some help, and personal interest, to read
some of your other reports. notably Nos. 55,and 64.
of
copies
If these are available, I would appreciate the opportunity to
read them before the meeting.

It

I look forward

to seeing you in Boston.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>March 28, 1968

Dr. Hilliam Zung

Veterans Administration Hospital
Durham, North

Dear

Carolina 27705

Bill,

pleased to have you visit us in New York and I have
Just spoken to Dr. Itil who told me of some of the excitement
at the meeting in Denver.
I was

set

us thinking about many
enjoyed your visit very much.
You

different problems,

and we

writing to ask you for two pieces of information.
interested in the predictors for convulsive therapy
and any suggestions you may wish to make regarding the use of
the depression scale, with the established beta weights.
Dr. Abrams will continue his study and this would be a useful
I am

I am

addition.

I have read the abstract of some of
and when these are available. especially
effects, I would be pleased to receive a
My

your reports in Denver
those relating to drug

preprint.

best regards.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>”arch 28, 1958
Dr. Stephen A. Weinstein
Labouatory of Behavioral Physiology
Johns JOpkins University

Baltimore, Maryland 21205

Dear Dr. Heinstein:
have read your letter to Science, describing the
Communications in Behavioral Biology. This reporting
system is of interest to us and I would be grateful for
any information regarding participation which may be
I

available. Is this system in operation

now?

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 28, l968

Dr. Daniel x. Freedman
Chairman, Department of Psychiatry
University of Chicago
950 East 59th Street
Chicago. Illinois 60637
Dear Dan.
Sol Goldberg has written asking that I send you copies
of the enclosed reports which have recently been completed.
These have been sent to Dr. Nittenborne forinclusion in the

Proceedings of the

ACNP.

It

was a

My

best regards.

l967.

pleasure to participate in the hallucinogen
reports are published soon.

symposium and I hope the

Sincerely yours.
Max

Fink,

M.D.

Prlfessor of Psychiatry

Mszp

�</text>
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                    <text>March 28. 1968

Dr. Ra1ph Jacobsen
Associate Medicai Director

Laboratories
Stewart Avenue
Garden City, New York
Endo
1000

11533

Dear Dr. Jacobson:

It

was very kind of you to send me a copy of the report
I think the idea is a very good one and. when
we are in a position to extend the na1oxone studies. I would
very much 1ike to adopt this method. 00 you think that your
chemist wou1d be ab1e to add ribofiavine to na1oxone? I am
sure that we can obtain the f1oorescent lamp suggested and

by 0r. Jones.

;

L

my

in

my

technicians cou1d carry out tests periodica11y.
Again,

New"?

v

my

thanks.

wg‘w/lw.

Sincere1y yours,
‘rvu'w

Fink, M.D.
Professor of Psychiatry

Max
it
E
E

i
E

1’
E

:-

I
E;

s
E

is
F

E

l

MF:kp

�</text>
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                    <text>35::

v.-

u",
m

vow-

:w
m

«nam-

Y.»nq7;'l«"M"

harch 28, 1968

.4
1'

-

/,.

xvr‘w‘

icw:'.4

men-mm:-

Dr. Michael C. Barry
Assistant Medical Director

'thite

Laboratories. Inc.
New Jersey 07033

Kenilworth,

Dear Dr. Barry:

visit to the Department of
of
Istanbul, where I met our
Psychiatry it the University
examined
some of'the patients receiving fluphenazine.
coworkers and
You may recall that we sent them a supply of fluphenazine concentrate.
A few weeks ago, in order to keep the study going, we sent a
small supply of higher concentrated tablets iron France. I
examined the records and saw 7 patients receiving high dose
fluphenazine.
I have

Just returned

from a

‘

‘

’

-

_

Three of the patients who had

failed to respond to standard

doses of phenothiazines have shown a dramatic improvement with
300 to 500 mg of fluphenazine daily. 0f the 7 patients, 5 had
received between 100 and 600 mg daily, up to l0 days. ~In one

patient

I saw

was ninimum
patient who

extrapyramidal'symptons but in the others. there

rigidity, obvious only on fine testing.
exhibited the most rigidity was part of

series, receiving

30 mg

daily.

I was most impressed

that the very high dose

The one
a low dose

was

safe (in

7 patients) and apparently useful.' Dr. Polvan-and his associates
are continuing, within the limits of the medication available.

this

may soon become available so that
Thank
you very much far your cooperation.
study can continue._
I

trust the concentrate

Sincerely yours.
Fink. M.0.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Twwwwm

March 28, 1968
Dr. Zola P. Horovitz

Squibb

Institute for

Georges Road

New

Brunswick,

How

Medical Research

Jersey 08903

Dear Dr. Horovitz:
I very much enjoyed having lunch today with you and the
other members of the staff of Squibb. As I mentioned, I am
enclosing a copy of a report which I have just completed and

submitted for publication in the Proceedings of the
I think this reflects my present position.
I would

ACNP

appreciate receiving a copy of your report in

the l966 Proceedings.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

l967.

�</text>
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                    <text>Earn»

"so

-

.mv

.,

w

t

\

.mn. mvm

-'w-«v)~'

x

v\~«v.«.-

wﬂvnh-a

,m

---«

-

"Maw“-

‘—

.wvr

‘

,

~

,

March 28, l968

Dr.

Julian

E. Rosenthal

Metropolitan Hospital
l901

New

First

York,

Avenue
York l0029

New

Door Dr. Rosenthal:

In October I had spoken to the Chairman of the Department
and Utilization
regarding my inability to attend the Audit
member
of the Department
Committee and was assurred that another

would be appointed.

unable to attend these meetings and ask that you
no longer mark me as absent and remove my name from the
Cami ttee .
1 am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

"an—-

wwé

“'4-

up

.
.

..

w“

"F"3*”“WW-Wwaw'r:r'ﬂwwwvwv

.

�</text>
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                    <text>March 28, 1968

Dr. Sidney Merlis

Director of Research
Central Isllp State Hospital
Central Islip, New York ll722
Dear 51d,

received a letter from Sol Goldberg suggesting
that I send you the three preprints which are enclosed. These
reports have been recently sent to Dr. Hittenborne 1n the
summaries of the 1967 meetings of the ACNP.
I have

I hope

that

I quoted your

in the phanttstice report.
My

mescallne studies accurately

best regards.
Sincerely yours,
hex Fink, M.D.

Professor of Psychiatry
MFrkp

�</text>
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                    <text>&lt;.'-r“"-‘-v

«NWT—“WWW“

.

March 28, l968

Dr.

Phillip Polatin

York
722 West

New

ﬂew

York,

Dear Dr.

State Psychiatric Institute
l68th Street
New

York

Polatin:

for thinking of me and sending me
the historic report of organic mental reactions during shock
therapy. This is a historic report, as it was one of first
Thank you very much

which communicated the

EEG

changes seen in these treatments.

first

teacher in EEG and I one
of my present interest to the enthusiasm which he
showed during my learning period in 1952—53.
Hans

much

Strauss

was my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 28, l968

Dr. Solomon C. Goldberg

Chief. Clinical Studies Section

Psychopharmecology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Sol.

the

fer the suggestion of sending preprints of
and Freedman. The preprints
revised and completed this week. I have sent the

Thank you

ACNP

have been

reports to Drs. Merlis

copies as you requested.

Sincerely yours,
Fink, ".0.
Professor of Psychiatry

Mex

MF:kp

.

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                    <text>March 28, l968

J. Prange, Jr.
Department of Psychiatry
Dr. Arthur

University of North Carolina
School of Medicine
Chapel Hill, North Carolina
Dear Dr. Prange:

Thank you very much for your paper "Enhancement of Imipromine
Antidepressant Activity by Thyroid Hormone." I have read this
with interest and can find little that I can criticize. The data
is impressive.

It may be of some help, and personal interest, to read
copies of some of your other reports. notably Nos. 55.and 64.
If these are available, I would appreciate the opportunity to
read them before the meeting.
I look forward

to seeing you in Boston.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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wﬁ-uva-yuv

m'm’ﬂﬁ'

'a'
.7"

mm

.

"'m,wmnz

March 28, 1968

w

narr-ra-mrr-M

Dr. Solomon C. Goidberg

Chief, Clinical Studies Section

'
.1,

w”

.i,.

n

rpm“.

Psychopharmacoiogy Research Branch

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

ﬁwV

(?
~..:

Dear So].

L‘“m

for the suggestigggof sending preprints of
the
reports to Drs. Meriis and Freedman. The preplints
have been revised and compieted this week. I have sent the
Thank you

ACNP

-.n

‘

copies as you requested.

5."me

Sincereiy yours,

4"“15

mew

r

Tun",

«cu-v

Fink, M.D.
Profossor of Psychiatry

Max

r-v

‘r'u‘

-.v.v~r-1wur

Mszp

..

-.
a",
a
a‘

WW‘WWW’Wr,‘

‘l”"—v“-T‘

rwv

H

Wu»:

�</text>
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March 28, l968

Dr. Daniel X. Freedman
Chairman, Department of Psychiatry

University of Chicago
950 East 59th Street

Illinois

Chicago,

60637

Dear Dan,
Sol Boldberg has written asking that I send you copies
of the enclosed reports which have recently been completed.
These have been sent to Dr. Wittenborn forinclusion in the
Proceedings of the ACNP, l967.

It

was a

My

best regards.

pleasure to participate in the hallucinogen
reports are published soon.

symposium and I hepe the

Sincerely yours.
Max

Fink,

M.D.

Prlfessor of Psychiatry

MF:kp

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                    <text>March 28, 1968

Dr.
New

Phillip Polatin

York

722 West

ﬂew

York,

State Psychiatric Institute
l68th Street
New

York

Polatin:

Dear Dr.

Thank you very much for thinking of me and sending me
the historic report of organic mental reactions during shock
therapy. This is a historic report, as it was one of first
which communicated the EEG changes seen in these treatments.

Strauss was my first teacher in EEG and I owe
present interest to the enthusiasm which he
showed during my learning period in l952—53.
Hans

much

of

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>north 26. 1968
Dr. Joseph Soiftor
Research Professor of Pharmacology
Dept. Coordinator of graduate Program
How York Medical College.
new York. "on York 10029
_

Door Dr.

Soiftor:

I have reviewed your request

to April

ll.

for lecturos

from April

l

.

It is difficult to undertake this mission at such short
notice since I will bo‘augy part of the time. The principal
other memter of the Department able to carry out this series
is-Dr. Herman c. 8. Dunbar. who can be reached at ﬂoohattan
-

Stoto Hospital.

Enclosed is o-list of the seminars now in progress in
(tho Department. .Porhaps those loctures, espociolly those

presented by the invitod speakers would be of interest to
the students. It is probable that those seminars will be
holo again in l969 and perhaps the noxt class of students
can be scheduled to ottond than at that time; or. we can
arrangt a special series for the graduate studonts.
Sincoraiy yours.
ﬂax Fink, M.D.
’Profossor of Psychiatry

ﬁfzkp

bet: 9r. Froeéaln

�</text>
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                    <text>March 22, 1968
Dr. Roger Meyer

National Institute of Mental Health
Bethesda, Maryland
\

Dear Roger.

Hiss Spiro called today and I tried to answer her questions.
Enclosed is a final draft of “Behavioral and EEG Studies of
Naloxone in Heroin Dependence” as submitted to Clinical Phermacolggz‘
and Therapeutics.

While we have been

told that

ENDO

will

naloxone, the approximate date is opened.

once again produce

present oyclazocine study program is in its final year
further studies will continue in the event the New York State
Narcotic Commission is willing to provide financial support.
The

and

has been an interesting experiment and I trust that this
report is helpful in the forthcoming presentation to Congress.

It

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                  <elementText elementTextId="102427">
                    <text>March 21, 1968
Mr. David Shapiro

Gracie Square Hospital
420 East 76th Street
New

York,

New

York

Dear Br. Shapiro:
I have ordered some equipment and

to Gracie Square Hospital to

supplies to be shipped

attention.

I would be grateful
you would notify your mail and receiving rooms that these
are to be accepted even though they do not have purchase orders.
I would be grateful if these would be put in the laboratory room.

if

my

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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                  <elementText elementTextId="105567">
                    <text>March 21,

368

Dr. James R. Merkel

Associate Clinical Research Director
The Squibb
New

Institute

Brunswick.

New

Jersey 08903

Dear Dr. Merkel;

revised the records of patient R.M., age 35
as requested in your recent letter. The patient had received
fluphenazine decanoate on 8/22 and 8/29. On a visit on 9/5
the patient states that she felt nervous, complained of
numbness and pains in the leg. tension. dysarthria and a
fear of crossing the street. The symptoms interferred with
her ability to concentrate.
I have

notation that the patient was “absent minded" was a
derivative statement which does not clearly reflect the data
on the record.
The

Because of the

patient‘s complaints. fluphenazine

decanoate was discontinued although there was no evidence
of an organic mental syndrome.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Max

.

MFtkp

�</text>
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                    <text>March 21. l968

Dr. Joseph 6. Bird

Sterling-Hinthrop Research Institute
Rensselaer, New York
Dear Joe,

pleased to tell you that an abstract describing our
experiences with cyclazocine as an antidepressant has been
accepted by the American Therapeutic Society for presentation
at their Honolulu session on June 12 - l6. A copy of that
abstract is enclosed.
I am

-

to attend this meeting and present this
be
may
helpful to have Dr. Zaks or Dr. Simeon

I am planning

report. It
participate with

me

in the event

Is

it

My

best regards.

we

stimulate interest.

possible for Sterling-Hinthrop to consider sending
participant to this meeting?

an additional

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
P.S.

May I

remind you to send me the names of the

last

few

patientS'treated with cyclazocine according to your records.

�</text>
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                    <text>March 20, 1968

Dr. Nathan 8. Eddy
7055 Wilson Lane
Bethesda, Maryiand 20034
Dear Dr. Eddy:

Enclosed is a page inadvertently omitted from the paper
“Intravenous Heroin Chaiienges in Studies of Opiate Dependence“.
Houid you piease insert this before putting the report
in the Proceedings.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>,
.

March

.

._,...,._,~,..

vw-v;—-......,.—._

_.

Dr.

l9, l968

Philip Bradley

The Medical School

Binningham
Dear

l5,

England

Philip,
When I

received the complimentary copy of Antioho£ineag£c

Danes I was very pleased. I think the
one and I look forward to the reviews.

presentation is

a good

wrote to Dr. Remarque concerning complimentary
copies for the participants, I found that we had agreed that
complimentary copies would not be sent to the authors.I
regreted this decision and have authorized Dr. Remarque to
send one copy to each of the participants at $7.00 a copy.
When I

I

trust this is agreeable to

you.

My

best regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>“’5

"wwwv,

&lt;

1w—vr.’~.v.w

-,—

-a—n—.-v.»

my,“

a-—-

“,.._.,.v.

"f-..

,

,
~.~.5--

March 18, l968

”-mmw.

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
.V

.

own—nun,

._.

mwﬂ‘1varcww-v

3181 S.H. Sam Jackson Park Road

Portland, Oregon 9720l
Dear Paul,

visit and could show you
and
Gracie
at MetrOpolitan Hospital.
Square
what we are doing at
Because of the organization of our project, in which Dr. Kalinowsky
is the consultant, I would ask that you not contact Dr. Impastato
to visit our project because this may complicate the relationships.
I would be

pleased to have you

it

To meet the staff of the Narcotic Addiction Program,
would be necessary to come during the week and if Wednesday
or Friday are available these would be ideal. If this is not
possible, I would be glad to meet you on Saturday morning, but
I cannot speak
We

could

for the other

visit

members

Gracie Square on

me when you know your

schedule.

of the

staff.

either day. Please call

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 19. l968

Dr. J. F. Remarque.
Elsevier Publishing

P.

O. Box

le

Vice President
Company

Amsterdam, The Netherlands
Dear Dr. Remerque,

believe a cooy of Antichotinengic ﬂange, Volume 28,
in Benin Reocanch, should be sent to each of the
senior authors. notably Drs. Hikler. white, Himwich, Votava
Herz, Vojtechovsky, Longo, Domino. Ilyutchenok, Euros
Carltoni
and
I

Paogeeao

t

.

For this reason I would be grateful if you would arrange
to send one to each of the senior contributors listed with a
note: ”With the compliments and thanks of the editors."

for

In addition, please send

15

copies.

Thank you very much

me

three

more copies and

for your coooeration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

bill

me

�</text>
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                    <text>March 18, 1968

Mrs. Mary Ann Stallings
826 Avalon Road, Apt. 6
Lawrence, Kansas
Dear Mary Ann,

Just returned from Europe and was saddened to
find your note waiting for me at home. While I only knew
Paul Feldman professionally, I admired his work and was
I have

pleased

when you confirmed my

opinion.

I do not know if there is anyone capable to continue
work
and so this would be a loss not only to psychohis
pharmacology but to Kansas as well.

are continuing to grow. The clinical
out-patient are quite active. We now
facilities
EEG
have an
laboratory at the hospital and one for basic research
at the College. The computer unit is very busy. It has takenI
me two years to find myself in almost the same place as when
left Missouri. but I hope I can build a professional program
from this base.
Our own programs

both in and

you plan to visit New York in the near future? If so,
I would be pleased to have you visit with us. My best regards.
Do

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mfzkp

�</text>
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                    <text>March 18. l968

Dr. Paul H. Slachly
Associate Professor
University of OregOn Medical School
3l81 S.H. Sam Jackson Park Road

Portland. Oregon 9720l
near Paul,
what

I would be
we

pleased to have you

are doing

at Gracie Square

visit

and

and could show you

at Metropolitan Hospital.

Because of the organization of our project, in which Dr. Kalinowsky
is the consultant, I would ask that you not contact Dr. Impastato

to

visit

our project because

To meet

the

this

may complicate

staff of the Narcotic

the relationships.

Addictihn Program.

it

to came during the week and if Wednesday
these would be ideal. If this is not‘
available
Friday
or
are
I
would
be
glad to meet you on Saturday morning, but
possible,
I cannot speak for the other members of the staff.

would be necessary

we
me when

could

visit

you know

»

Gracie Square on

your schedule.

either day. Please call

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>mum-warr-

March

l8,

1968

Dr. Merle L. Gibson
Di rector

Acting

Division of Neuropharmacological
Office of ﬂew Drugs
Bureau of Medicine

Washington, 0.6. 20204
Dear Dr. Gibson:

RE:

IND

2640

When I left the University of Missouri in 1966. the
remaining supplies of CI-395 and the study program was turned
over to the director of the Section of Psychopharmacology. Dr.

Turan

M.

No

ltil.

studies of 61-395

May I

have been undertaken in

suggest that you write directly to

further information.

him

New

York

for

any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

Dr.

Fletcher

A. H.

l8, l968

Owens

Robins Company

1407 Cummings Drive
Richmond 20, Virginia

Dear Dr. Owens:

recent conversation you indicated that the on-going
of
tybamate in the treatment of narcotic addiction, using
study
dosages up to l2 grams daily exceeded the recommendation on the
In our

pncﬁﬁge

'

insert.

As you know, we have already reported on an initial group
of patients with these dosages without problems. You indicated
that a revised IMO is being submitted to the FDA and that this
would be done within the next two weeks.

Insofar as it would raise problems of withdrawal and be
medically contraindicated, the present group of patients will
continue to be treated during these two weeks but we plan not
to add any new patients until the IND has been filed.
Thank you for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 26. l968

Dr. Joseph Seifter
Research Professor of Pharmacology
Dept. Coordinator of Sraduate Program
new York Medical College

New

York. New York l0029

Dear Dr.

Seifter:

I have reviewed

to April

ll.

your request for lectures from April l

It is difficult to undertake this mission at such short
notice since 1 will be away part of the time. The principal
other neuter of the Department able to carry out this series
is

Dr. Herman C. B. Oenber, who can be reached

State Hospital.

at

Manhattan

Enclosed is a list of the seminars now in progress in
the Department. Perhaps these lectures. especially those
presented by the invited speakers would be of interest to
the students. It is probable that these seminars will be
held again in l969 and perhaps the next class of students
can be scheduled to attend then at that time; or. we can
arrange a special series for the graduate students.

Sincerely yourS.
Fink, M.D.
Professor of Psychiatry

Hex

Nszp
bcc:

0r.

Freedman

�</text>
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                    <text>MarCh

Hr. Joseph V. Moran

7

I4.

1968

,«

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase. Maryland 20203
Dear Mr. Moran
I am

Re:

MH—13358-02

and l3003-02

writing with regard to the restriction in international
March 6. l968.

travel in your letter of

For many years, we have participated in the meetings of
the GIMP - the principal international organization 9 devoted
to psychopharmacological research. The next meeting is
scheduled for April 24 - 27 in Tarragona.5pain. There are two
presentations by members of this staff on that program.
Funds

for this travel are available in ”ii-13358

and 13003.

like to send one representative of this program
both
to present
reports. Curtailment of all travel would
serious embarrass the organizers of this meeting and would
He

reflect

would

the integrdty of our commitments. We would be
grateful if permission could be granted for one participant
only instead of the two permitted for in these grants.
on

Thank you very much

for your understanding.
Sincerely yours.

Mathink,

M.D.

Professor of Psychiatry

Mszp

-

'

�</text>
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                    <text>March

l2,

1968

Dr. waiter Modell, Editor
Clinical Pharmacology and Therapeutics

Professor of Pharmacology
Cornell University Medical College
l300 York

ﬂew

York.

New

York lOOZl

Dear Dr. Model]:
I am pleased to enclose an original and one xerox copy
of our report "Behavioral and EEG Studies of Naloxone in
Heroin Dependence" for your consideration for publication
in Ctinieaz Phanmacotogy and Theaapeuzica. while this report
describes our experiences with a small number of subjects,
we believe the data to be of sufficient interest and timeliness.
The studies cannot be extended because supplies of naloxone
are not available at present.

Thank you

for your consideration.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

7. 1968

Miss Mary-Frances Thompson

Coordinator. Special Science Projects
American Institute of Biological Sciences

3900 Wisconsin Avenue. N.“.
Washington, D.C. 20016
Dear Miss Thompson:
Thank you very much

for your invitation to attend the

the average evoked potential.
would like to participate.
and
invitation
your
NASA

conference

on

I

accept

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

Dr. Joseph

Jaffe

The William.Alanson white
20 West 74th Street
New York, New York

7, 1968

Institute

Dear Joe,
I have

the g;§.M.D,

a

read your report on deniie personality in
I found it very interesting and would appreciate

just

reprint when this is evaiiabie.
Incidentally I hear that Ed Heinstein

to Mt. Sinai this summer.
My

may

be returning

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

Dr. William

M. K.

7, l968

Zung

Assistant Professor of Psychiatry
Veterans Administrttion Hospital
Fulton Street and Erwin Road
Durham, North Carolina 27705

Bill,

Dear

I look forward

If

you come-in the evening
(516 466-5444).

home

and

to seeing you here

I

would

like

you to come

First Avenue), at 10:00

on Wednesday, March

before, please call

me

any.

He

will

to Metropolitan Hospital (97th
lSth floor, Mental Health Clinic.

make up

visit the laboratories
the rest of the agenda as we

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

my

am,

In the afternoon I would like you to

at l?2nd Street.
go a

at

l3.

�</text>
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                    <text>March 7, l968

Dr. Lee E.

Hollister

Associate Chief of Staff
Veterans Administration Hospital
3801 Junipero Serra Blvd.
Palo Alto. California 94304
Dear Leo.

.

While I have more than a half dozen reports that are
waiting to be done, I am stimulated to accept your invitation
to write a summary of EEG and drugs for practicing physicians.
I would rather not give you a date because I am sure I cannot
meet it, but I am sure I will attend to this at the earliest
date I can.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>.

,

ﬂarch 7, l968

Dr. T. Robitscher
Assistant Medical Director

Ayerst Laboratories

685 Third Avenue
New York. New York lOOl7
Dear Dr. Robitscher:

Since our discussions in Puerto Rico 1 have sought, in vain.
to set up a study of Sordinol which you described so well.
Unfortunately, the population available to me at a neighboring
state hospital does not lend itself to long tenm studies.

are interested in undertaking evaluations
in adult acute mentally ill and have available populations of
depressives as well as acute psychotics. If I there are other
studies of interest to Ayerst Laboratories, would be pleased
to have you call on me.
As I

My

mentioned.

we

best regards.

.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March

6, l968

Dr. Marshall Gates

Professor of Chemistry
University of Rochester
Rochester, New York
Dear Dr. Gates:

associate, Arthur Zaks. who presented the report on
at the recent NR6 meetings, reported that you had As
infonnation regarding another active narcotic antagonist.
we indicated, there is great difficulty in obtaining supplies
of naloxone and I am not optimistic that these studies will
be continued. The model of narcotic antagonism for treatment
is an interesting one and we would like to continue our studies.
For this reason. I am writing to inquire as to any
information which may be available regarding additional
antagonists.
My

naloxone

Thank you

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March

lilliem

6, l968

Martin
Director, Addiction Research Center
Dr.

R.

NIHH

Lexington. Kentucky
Deer

Bill,
I have read

thaoozogical
reprints are

your review of Opioid antagonists in
Review with a great deal of interest.

still

I look forward

available,

to seeing

I would be

grateful for

you next week.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Max

Mszp

If

a copy.

�</text>
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                    <text>March

6. 1968

Dr. Joseph G. Bird

Director of Experimental Medicine
Sterling-Winthrop Research Institute
Rensselaer, New York 12144
Dear

Joe,

The question of withdrawal symptoms upon discontinuation
of cyclazocine after extended use was discussed in the reports
published in the J.A.M.A. and to appear in the American Journal
of Psychiatry. Y3§~ﬁay recall that a variety of symptoms were
recorded by the patients upon acute withdrawal. These included
increased irritability, headaches. suspiciousness. depression.

a'hrippe-like” syndrome. The sy-ptoms persisted for one to
three days and were not serious enough to warrant treatment.

and

We concluded that in the usual treatment with
cyclazocine
the termination should be accomplished over a three to five
day period, much in the way the termination of imipramine
treatment is ordinarily concluded.

In those subjects who spontaneously stopped cyclazocine, we
have never had a complaint regarding any significant secondary
e facts.

It has been our impression that the withdrawal symptoms to
cyclazocine are of an order of magnitude and most similar to the
withdrawal symptoms reported for imipramine.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>rr.

,r.

r.»

memuvww

March 5, 1968

r“

u

wwyljr

,Wa—=«.Wn

Mr. Vincent L. Reyaschieri
l03~l Avion Hay

Minot

a.“

"a.”

AFB

Minot. north Dakota 5870l
Dear Mr. Ravaschieri:

‘
"
'
"
'

w,

WM"-’S""

We»

1.1-

2—way

Ware-ﬂmmr‘

Thank you for your reply to our ad in the New York Times
for a Research Assistant. We are interested in your qualifications and would like you to communicate with us further as the
time approaches for your military separation, regarding the
possibility of a position in our laboratories.
Our research involves the evaluation of changes in brain
function associated with pharmacologic agents based on digitalcomputer EEG analysis. using as subjects. psychiatric patients,
narcotic addicts, and normal volunteers. The enclosed reprints
will give you an indication of our studies.

w

We

.

look forward to hearing from you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

kp

..

‘6er

�</text>
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                    <text>March

Dr.

5. 1968

J. Hittenborn

Rutgers The State University
New Brunswick. New Jersey
—

Dear John,
IV:

With reference to our

report

Clinical Antidepressants,"

and Human Psychopharmmcology
would you please insert page 73
"EEG

immediately following page 7? I am also enclosing the legends
for figures 7 and 8, which should be inserted Just before the

references.

Thank you very much.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

Dr.

Fletcher

5. 1968

Owens

Robins Company

A. H.

l407 Cummings Drive
Richmond 20, Virginia
Dear Dr. Owens:

have recently completed a preliminary report of our
experiences with tybamate (beatran) in the treatment of narcotic
We

addicts.

A

It was

that report is enclosed.
our conclusion that the failure to observe the
copy of

reduction in drive for Opiates

may

have been

related to the

incomplete security measures on our ward. There was some
suggestion that the tybamate was effective in some of our
patients. We decided to replicate this study under better
environmental controls.
In addition, the tybamate seemed useful in withdrawal
of patients addicted to barbiturates. For this reason we
revised our protocol.
,..,

«1.,

.

I am pleased to enclose a cepy of the preliminary report
dated December Zl, 1967 and the protocol revised January 3, 1968.

—

I want

...,-

_

.
.
.—

....

to thank you for your continuing cooperation in

this project.

..,

.,

Sincerely yours.

we"

"-1-"

..

..

-‘~7-—va~.,;

Fink. M.D.
Professor of Psychiatry

Max
a
&lt;

MF:kp

�</text>
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                    <text>'l'ﬂlm’lfrw

mtg-“rum

rrmv-wu-ri

w

1”“

March

Dr. Zdenek Fink
Purkyne Medical Research
Hradedec Kralove

4, 1968

Institute

Prague, Czechoslovakia
Dear Dr. Fink,

I returned from my whirlwind tour of Prague to be greeted
warmly by my family despite the changes in my appearance. I
told them of my trip and I showed them the many small remembrances
from the visit to Kalicha. I want to thank you for your warm

we come.

have written to Dr. Vthechovsky I believe you have
fine research program. I hope there will be more time
at the next visit to discuss at greater length the projects
As I

a very

interest us. In the meantime I am taking the liberty of
a copy of the cholinergic report that may be of
interest.

which

enclosing

Again. many thanks.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

Dr. Clive

M.

4, 1968

Tonks

Research Associate

Yale University School of Medicine

Department of Psychiatry
34 Park Street

New

Haven. Connecticut 06519

Dear Dr. Tonks:

changes in the menstrual
cycle are De Barenne and Gibbs; Amer. J. Obstetric Gynecology,
l942. 1944: 672-675; Lettich and Margerison, EEG Clin. Neurophysiol.
196l, l3: 606-611; Margerison et al.. EEG Clin. Neurophytiol. l964,
l7: 540-544; and Matousek Research Reports, Psychiatric Research
Institute (Prague) 9, 1967. 223-225.
The

principal references to

EEG

In addition, there is an unpublished report by George Ulett
and you can write to him at the Missouri Institute of Psychiatry,
5400 Arsenal Street, St. Louis, Missouri 63139.
The

reprint you requested in enclosed.

Please give

my

regards to Dr. Klerman.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc .

�</text>
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                    <text>March

4, l968

Dr. Max Hamilton

University of Leeds
Department of ngchiatry
l5 Hyde Terrace
Leeds 2, England

The

Dear Max,

of you to think of me, but I know very little
about the University of Vermont. It is among the newer schools
situated in one of the most beautiful parts of the East. Skiing
in the winter and swimming in the summer are within twenty to
Boston and
thirty minutes of the city. It is well located for
between
talent
there is an active change of professional
Burlington and that city. As Albany achieves greater prominence
in medicine, perhaps the relationship will shift to New York.

It

was kind

recollect that George Brooks was active in that area and
perhaps you would write to him for more information. Perhaps
the best source would be still be Milt Greenblatt who seems to
know everyone in that part of the country.
I

Incidentally, in the same mail I received a letter
student, Clive Tonks, who is writing with regard to the
in menstruation.

from your
EEG

changes

Perhaps we will meet in the forthcoming meetings in Tarragona.
In the meantime. my best personal regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March 4. l968
Dr. Necmettin Polvan
Abdulhak Hamid Cad. 76/4 Serin Apt.
Taksim ~ Taliehane
Istanbul, Turkey
Dear Dr. Polvan:
You know that I enjoyed my visit to Istanbul
very much.
Your hospitality and that of your associates was overwhelming.
But most important, I was enthusiastic about the
progress of
the fluphenazine and butaperazine.studies.

return, I found your letter requesting some medical
supplies from the United States. I regret that I had not
received this before I left for I would surely have complied.
Please excuse me.
On my

Dr. Itil about the studies and have
plan to meet earlier in the week of the GIMP
meetings to write the report for presentation. I have told
him of the tables 1 suggested and I am sure that he
will write
to you either confirming or changing the outline.
I have

written to

suggested that

we

I look forward to seeing Miss Guven in New York

early this
yourself in the fall. Please extend my best personal
regards to Drs. Ziyalar. Yagcioglu and Songar for their courtesy

summer and

and patience during my

visit.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>.,.

March 4. 1968

Professor

Jiri

Roubicek

Psychiatric Research Institute
Prague, Czechoslovakia
Bear Dr. Roubicek:
While my visit to Prague was very short, I enjoyed every
and returned enthusiastic with the expectation
minute of
of your visiting New York later this year. I especially enjoyed
meeting Drs. Volavka and Matousek. Their spirit and excitement
in their work was most encouraging. I hope it will be possible
for both to join you in New York.

it

After leaving you in the airport I was fortunate in finding
beautiful cut glass vase which will grace my home and remain
continuing reminder the pleasant days in Prague.

a most

as a

Please extend my thanks to your wife and daughter who were
so hospitable and who made the evening at the opera so enjoyable.
My

.A

.

best personal regards.
Sincerely yours.

A,...,,_V...

.

.
_.

,A

m.

Fink. M.D.
Professor of Psychiatry

Max

..=.

—,,....u..‘—,.—~n,

MF:kp

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                    <text>“an"...‘ﬂq. ,

.,.‘Mq_...‘.e.“._.x;n.,

h...

r.

...w‘

\

.

_. ..."

m,“

3 "as-..

(a, yr, ,7»,

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v...

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v:‘.\v--

,.

My- man .

M.” ..;e, .. r

”'4

_

.

..

...

March 4. l968
Dr. Hilos Vojtechovsky
Institute of Pharmacology
Medical Faculty of Hygiene

Charles University
Praha l0 - Vinohrady, Srobarova 50
Czechoslovakia

Dear Miles.

that the visit to Prague was short but it was most
enjoyable. At first, I did not think there was enough time to
visit the city and also carry out the assignment I had made for
myself in visiting different laboratories. I very much enjoyed
meeting your associates and both Dr. Fink and Benesova as serious
and sophisticated workers. You are indeed fortunate in having
their collaboration and advice.
I know

Incidentally, it was kind of you and Dr. Roubicek to have
arranged for me to speak to your Society. I have made good use
of the honorarium, for at the airport I was able to buy a vase
of cut glass which will remain at my home'as a reminder of my
exciting time in Prague.
I also want to thank you and your wife for your many kindnesses
and the fine dinner. I look forward to seeing you in Spain.
My

best personal regards.
Sincerely yours.
Fink, ”.0.
Professor of Psychiatry

Max

MF:kp

.

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                    <text>March 4, l968

Drs. J. Volavka and M. Matousek
Psychiatric Research Institute
Prague 8, Czechoslovakia
Dear Drs. Volavka and Matousek:
I have written to Dr. Roubicek to thank him for his many
kindnesses during my visit but I am also taking this opportunity
to thank you for your frankness and the welcome you extended
during my visit last week. I hope that it will be possible for
you to come to New York for I think that you iill enjoy your
experiences here and I believe we can make some contributions
to quantitative electroencephalography.

taking the liberty of enclosing a copy of the book
was written as his thesis fer the
It deserved a better review than
that given by Dr. Goldman and is, in my opinion, the best
available summary of a very difficult subject. Someday Charles
Shagass will write a summary of his work and the two together
will provide the cornernstone for the neurophysiological
classification of subpopulation for the medically ill.
I am

written by Dr. Itil. This
professorial examinations.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>A,

w...

'33

«wt-A".

“4-4,;

Anal-

Harch 4. 1968
Dr.

Mi

1ton Tar1ao,

Secretary. Eastern Association for
Electroencephaiography

80-02 Kew Gardens Road
Kew Gardens, New York 11415
Dear Mi1t,

I take great p1easure in endorsing the membership
Dr. Aaron J. Barman in the EAEEG.

tion of

I have known Joe

for

many

appiica-

years and have foiiowed his

neurophysio1ogic studies with great interest.
surgeon with a fine research interest.

He

is

a neuro—

During the past six months I have had the opportunity
work more closeiy with him in the anaiysis of EEG data
from his brain damaged monkeys. I think the presentation
which he made at the meetings in Canada wiii 1end support

to

to this recommendation.

I endorse his appiication and iook forward to his active
participation in the association.

Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>February

l2, l968

Dr. Louis Nest

Professor of Psychiatry
University of Oklahoma School of Medicine
Oklahoma City, Oklahoma
Dear

Jolly,
My

associate,

Donald

M.

Shapiro, will be visiting

Oklahoma

City on a site visit to a computer facility late in February.
Dr. Shapiro is the director of the Division of Biomedical
Information Processing. New York Medical College. and has been
associated with me in EEG analyses since l963.

of your interest and that of your associates in
psychophysiological data handling. 1 have asked Dr. Shapiro
to try to visit your computer facility, accompanied perhaps
by a member of your staff who can discuss your ongoing programs.
I have asked Dr. Shapiro to call your office in the hope that
such a visit might be mutually rewarding.
Knowing

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February l2, l968
Dr.

J. Hittenborne

Rutgers - The State University
26 l/2 Morrell
New Brunswick, New Hersey
Dear John,

Enclosed are two reports given in the recent

ACNP

meeting.

The report “EEG Classification of Psychoactive Compounds
in Man," is complete. The report ”EEGeand Human Psychopharmacology
IV: Clinical Antidepressants" is minus legends for Figures 7 and 8.
The third report “Neurophysiology of the Phantastica" will be a
similar review to the EEG classification of approximately 20 pages
text and lo pages citations. Unfortunately I could not
finish that before I left for Europe and rather than send you the

edited

copy from which Dr.

ask your indulgence and
Thank you

it

Itil

and I have been working, I would
should be on your desk by March 8.

for your patience.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

dictated but not signed

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                    <text>February 9, l968
Dr. Nonman Pitts
Chas. Pfizer a Co., Inc.

Groton. Connecticut
Dear Dr.

Pitts:

Enclosed is a revised protocol for the continuation of

our Doxepin studies. You will note that the next group of
newly admitted anxiety cases will receive doxepin without

necessarily havtng‘a preliminary period of treatment with

doxepin.

Please

amend our

project file.

Also, thank you for the matching capsules of doxepin,
chlordiazepoxide and placebo which arrived yesterday (Thursday).
I

look forward to seeing you March 7,

3pm

at

5

East lOan St.

Sincerely yours,
Max

Fink,

M.D.

Professor of rsychiatry

MF:kp

�</text>
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                    <text>February 8, l968
Dr. Nafi Kiremitci

Jersey State Hospital
New Jersey 07746

The new

Marlboro,

Dear Rafi,

for

Enclosed are some reprints and a proposed protocol

of clopenthixal. Enough
to satisfy our initial interest, but
study is indicated.
a study

I

will call

March 5.
My

you when I

work has been done
a comparison, long term

return from Istanbul, about

best to Betty.
Sincerely yours,
Max

Fink,

M.U.

Professor of Psychiatry

Mszp

�</text>
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                    <text>WW

1,

”an,“

.mwwm.

w...”

wwqg-

m-I‘FV‘V.2}.

rs

nun-M—

”rm

.1

, .7

i

i

i

February 8, 1958
Mr. William 801d
E. R. Squibb and Sons
Georges Road
New

Brunswick.

New

Jersey 08903

Dear Mr. Bold:
w

‘4
v

i

”0"";

Enclosed is a revision of our protocoi of studies of
fiuphenaZine. These modifications are effective as of this
week and re5u1t from our recent review.

nah”,

I

.
n

would appreciate your making

this

a

matter of record.

\

Sincereiy yours,

”mks..-

.
"vi-v1."-

Max

—~
s.
A

wort.“

.m-Vyrww_

‘

A

.

w-m'vm—W—_~,n

wmmn'

Fink,

M.D.

Professor of Psychiatry

m—m‘rﬂ-mu’ﬂ

Mszp

�</text>
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                    <text>,

w

.,

».

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son an.“ nan-r" "'4’".

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Febluary 7, l968
Dr. Milos Vojtechovsky
Institute of Pharmacology
Medical Faculty of Hygiene

Charles University
Praha l0 ~ Vinohrady, Srobarova 50
Czechoslovakia
Dear Miles.

Enclosed is a cony of a letter to Frofessor Roubicek which
explains my arrangements. I want to thank you for your invitation
to stay with you. but I would prefer that I
at your most
convenient hotel. I will be grateful for anystay
arrangements
you
make with Professor Roubicek which
will penmit me to get a
personal impression of both your laboratories and your work.
I look forward to seeing you

at the

end of the month.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>February 7, l968
Dr. William lung

Assistant Professor of Psychiatry
Duke University Medical Center
Durham, North Carolina 27706

Dear Dr. Zung:
Both Professor Freedman and I were delighted when we
vitae. I would like very much to have

reviewed your curriculum

you

for

visit

York at
week trip

New

three

a

our expense. Unfortunately. I am leaving
this Saturday. I plan to return March 2.

is a presentation from these laboratories at a local
on March l4 and Dr. Freedman suggested that this might

There

society

visit as it will give you an opportunity
to know something of our recent work. But this is only a
suggestion. May I ask you to call my secretary at (2l2) 369~7900
Ext 245 and arrange a date which is also convenient for Dr. Freedman,
alternately to March l4, during the first week in March, except
be an appropriate day to

March 7.

It has taken me a bit more than a year to get the clinical
and laboratory facilities operational. But we now have patients
on two wards at Metropolitan Hospital and from the clinic available
for study. There are two fully equipped EEG laboratories and our
computer installation of an IBM l800. Most important to me, is
the fact that Dr. Donald M. Shapiro was appointed director of the
Biomedical Infonnation Processing Division of the Medical College.
He is co-director of the l800 unit and his larger facility (360 MOD 30)
is available for any larger data processing. This collaboration
between a computer unit. the EEG laboratories and the clinic have
been very exciting during the past few months.
join

I look forward

us soon.

to your visit

and hone

that

we

can have you

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>r
..—.~

..

'F‘Wl'vi-

,«r-v

vam-

471’

w-a

«rev

.w

.‘W.

yum,”

_

_

T

-v," va...

w -.

-

-v—v .7

-v

w7‘

Amy-”7W?m ‘1. wwnwﬂwrkﬂinmw‘yw

ﬂaw-'-

var—swam
.

.

,

w .r.

:c

-

.,._.

"'

x.

-

—-.—w

1-“ inn-x

inn”...

;.v —.. w...

~»

"

February 7, l968
CIA. Hispanoamericana de Turismo

Paseo de Gracia, ll
Barcelona 7, Spain
Gentlemen:

accept the reservations made for me at the Imperial
Tarraco.. It is not clear to me whether you are expecting
prepayment or not. In the meantime. please accept this
I

reservation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 7, l968
Dr. Necmettin Polvan
Abdulhak Hamid Cad 76/4

Serin Apt.
Taksim, Istanbul
Turkey

Dear Dr. Polvan:
Dr. Itil has written, I am planning to visit Istanbul
end
of February. My present plans are to leave Zurich
at the
on Swiss Air 326 on Sunday, February 25. The flight is scheduled
As

to arrive in Istanbul at 7:05
Dr.

grateful

pm.

Itil suggests that I stay at the Divan and I would be
if you would call them and make a reservation on my

Failing that, I would trust you to
at any hotel convenient for you.

behalf.

As I

understand my mission.

it

make a

reservation

is to see the patients with

you on high dose fluphenazine; to review the butaperazine project;
and to visit your hoSpital and, if possible, the Bakirkﬁy in

order to maintain our relationship with that institution.

this trip I would like to visit the laboratory of
Professor Roubicek in Prague and have scheduled a flight
from Istanbul to Prague on February 28.
On

I look forward

best regards.

to seeing you at the end of the month.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

My

�</text>
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                    <text>February 6. l968

9r. J. Roubicek
Psychiatric Research Institute

Prague. Czechoslovakia
Saar Dr. Roubicek:

My plans for the trip to Europa this month have
crystalized sufficiently for me to give you my itinerary.
Because of flight schedules. I will be visiting Istanbul
first and plan to arrive in Prague in the afternoon of
February 28. Because of the possibility that I may be in
Istanbul an extra day. I will cable the exact arrival
wlich will probably be on 0K 952 from Vienna at 4zl0pm.

Would

it be

too much of an imposition to have you

call one of your local hotels
me for 3 nights.
As I

wrote

originally,

and make

I am

reservations for

writing concurrently

Dr. Vojtechovsky in the hope that I can visit with
him for part of the time. Any arrangements that you
and he can make will. I am sure be agreeable.

to

My

best regards.
Sincerely yours,

Haerink, ”.8.

Professor of Psychiatry

Mszp

�</text>
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                    <text>February 6. l968
Dr. Nathan 8. Eddy
7055 Wilson Lane
Bethesda. Maryland 20034
Dear Dr. Eddy:
Dr. Freedman wishes me

to thank

you

for your kind

comments

in your recent letter to him. He are pleased to enclose original
glossy prints of the four figures which we included in the

report

on naloxone.

As we have described in the report, naloxone appears to
us to be one of the more interesting new compounds and we

strongly recommend its continued study. Unfortunately, the
supplies have been curtailed for a variety of reasons which
seem to us alterable. He will appreciate your efforts in making

this

compound

available.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Nszp

�</text>
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                    <text>a..- ...,&lt;,.

,.

.

....

-"'.1‘ n.

n;

February 6. l968
Dr. Leo E.

Hollister

Associate Chief of Staff
Veterans Administration Hospital
380l Junipero Serra Blvd.
Palo Alto, California 94308
Dear Leo,
Dr. Henry

Elliott

has invited the review of

human psychopharmacology and I am very

EEG

and

grateful for your

recommendation. In preparation for the ACNP meeting I
did complete the review until early summer l967, but I
will continue with the literature and trust that it will be
as useful as your reviews have been.
Again,

my

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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‘n

rune-mammal

«

.mmmwr

c—‘I-wvvenrtum

February 6, 1968

-u7ﬁww

Mn‘ﬂﬂmi.m~ww—

«--

Mr. Henry N. Elliott, Editor
Annual Review of Phanmacology
4139 El Camino Hay
Palo Alto, California 94306

'm‘mw—rw-mn

v.7

r
own-«w;

v

Dear Mr.

Elliott:

Thank you very much for your kind invitation to contribute
a review on "Human EEG and PsychOpharmacological Agents" for
volume 9 of the Annual Review of Pharmacology. I am pleased

to accept your invitation and will prepare this review
the spring.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

later in

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                    <text>...

.

.m

..

ﬂ.
.,

..._,-..

alas-r

February 6. 1968
Dr. Alain Sanseigne

Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

It

was very kind of you to participate in our program on
I enjoyed very much your hospitality.
and
Friday

mentioned in our discussion, I recently came across
the following citation which will interest you.
As I

Czerwenka-wenkstetten, H. and Hoffmann. @Clinical Experiences with Helleril-retard.
Mien. Klin. Wschr., 1966, 78-48: 845-847.
Again my thanks.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

P.S.

Enclosed

is

a

the ticket with you.

ticket for “Titicut Follies.“ Please bring

�</text>
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                    <text>February 6, 1968

Jostrand
Corporation

Mr. Mayne
IBM

211 Montague

Brooklyn.

New

Street

York 11201

Dear Mr. Jostrand:

that unless the
defined
there
computer is clearly

months ago I reminded Bob Shearman

Many

billing for the
will be continuous bookkeeping
The

IBH 1800

bills

hold

are addressed to Dr.
5th Avenue

IBM

Max

difficulties.

reference 64762-06. 083081. These
Fink at the New York Medical College,

at 106th Street.

.

it

does not define the
This is unsatisfactory since
unit as separate from other units within the medical complex.
Would you

please ask your bookkeeping office to send a

all invoices for 1967 to me and arrange to have the
account readdressed as installed at the Department of Psychiatry,
New York Medical College, 5 East 102nd Street (8th floor).
copy of
New

York 10029.

Also mark the invoice to the same location.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>u

February 6, 1968
Dr. Jacques F. Remeroue

Elsevier Publishing

Company

P. 0. Box 2ll
Jan van Galenstraat 335
Amsterdam, The Netherlands
Dear Dr. Remarque:

I received Volume 28 of Progress in Brain Research and
wish to compliment you on an excellent technical production.

It

would be most useful

for

you to send the remaining

complimentary copies of the volume to
Medical College, 5 East l02nd Street.

my

ﬂew

office at the

'.»~'.Ilr'~x

York

inquire as to the policy as to the publishers with
each
of the contributors? I do not recall the contract.
to
regard
the
contributors
are not to receive a copy of the publcation
If
then I would like to send each of them a cupy. would you be kind
me what the price for additional copies are to the
enough to tell
May I

ed

tors?

u‘

"when“

New

York. new York l0029.

It

has been a pleasure to work with Elsevier.

Sincerely yours,
""I'K'rv-l-Jr'ruw'

Fink, H.D.
Professor of Psyhhiatry

Max

Mszp

�</text>
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                    <text>February 5. 1968
Br. Henry L. Giordano

Commissioner of Narcotics
Federal Bureau of Narcotics
633 Indiana Avenue, N.H.
Washington, 0.6. 20226
Dear Mr. Giordono:

During the past year we have studied the clinical efficacy
of naloxone in the treatment of narcotic addiction. The
manufacturer, Endo Laboratories. has been unable to supply
additional material because of the expenses involved. At their
request. we are enclosing a copy of a preliminary report of our
experiences. It is my understanding that David L, Klein,
Senior Vice President of Endo Laboratories plans to discuss this
project with your office.
Your cooperation in making this compound
be appreciated.

further study will

available for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.

Hszp

�</text>
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                    <text>February 1, 1968
Dr. T. P. 5. Watts
Geigy Pharmaceuticals

Ardsley,

New York

l0502

Dear Paddy.
I am

sorry

I missed you

your office you were out.
Enclosed

at lunch today.

Please read

best regards.
Sincerely yours .
Fink, M.D.
.Professor of Psychiatry
Max

MF:kp

enc .

called

is the status of the ketimipramine study

which I had planned to share with you.
and call me at your convenience.
My

When I

it

�</text>
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                    <text>.

.7

My...”

run-wwu

'B-nU—WU—w-H‘Wkw

w»&lt;W-mrnwmvtwwlvw~ns

r

'1

-~

WW,

..-..-

-

:v-

1',u~&lt;

.

...

p -:v~ ‘IY'V" wm‘ww-r'wm"‘

"-v-

“a;

January 30. 1968
Dr. A. Karczmar
Loyo1a University

Stritch

Schoo1 of Medicine
Hines, I111nois 60141

Dear Dr. Karcimar:

P1ease rep1ace the 1egends by this page which has two

corrections.

Sincere1y yours,

Max

Fink, M.D.

Professor of Psychiatry

MFtkp

,

mwzg,

�</text>
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                    <text>,

at“

an

—,

.r‘

.-..-,7.-.

meq-uuc—

ﬂanuary 29, 1968
Dr. A. Karcznar
Loyo1a University
Stritch Schooi of Medicine

Hines, I11inois 60141

Dear Dr. Karczmar:

Enciosed

is

of Cyciazocine.

that:

Note

A

draft of our report.

a revised

Narcotic Antagonist." and

.

"or.

#0353“

0
o

a

050'?

o

a

Patterns
additionai figures.
“EEG

Authors - revised

Credits
Pages

—

4—9

revised
- revised

Reference pg. 1.

citation

Freedman gt_gl; - updated
Figures added
Legend added

Please revise the draft in your hands according1y.
Sincere1y yours.

Fink, M.D.
Professor of Psychiatry

Mex

Mszp
GRC .

.
q.

WVMWW

'

‘

�</text>
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                    <text>.
",4

m—Apﬂ',’(‘ﬁv~hrjmwrr&lt;

January 29. 1968
Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York.

New

York

Deer Alain,

Enclosed is a copy of the staff announcements for
this Friday's presentation. and a copy of Luigi’s notes.
Dr. Simeon will report on the data from Missouri, and a
copy of that report is enclosed.
As I mentioned, I would be grateful if you would join
me about quarter of eleven, l5th floor, Metropolitan Hospital
in the Mental Health Clinic (inquire at the psychiatric office).
At ll o'clock I would like you to Join me in talking to the
resident physicians about the methods ind problems in new drug
evaluation. They have had two lectures already, one on the
history of psychooharmacology and one on models and classifications
0 drugs.

Turan

is planning to Join the

can have lunch afterwards.
My

noon

lecture

and perhaps we

best regards.
Sincerely yours.

4.,

Fink, M.D.
Professor of Psychiatry

Max

_.

we!

we

Wm

.mm

MF:kp

�</text>
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                    <text>January 29. 1968
Dr. Joseph G. Bird

Steriing~winthrop Research Institute
Rensseiaer, New York 12144
Dear Joe.

Enclosed is a revised and updated capy of the report

of our EEG studies with cyciazocine. The originai was
presented at the ACNP meeting in 1966 and it is now going

to press.

‘

of the clinical experiences with cyciazocine
as an antidepressant is continuing and we should have a report
The review

avaiiabie very shortly.

Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max
NF: kp

enc.

�</text>
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                    <text>January 29, l968‘
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39
Dear Turan.
Dr. Karczmar has asked us to revise the 1966 ACNP
report.
In view of the fact that this paper reports our
original
descriptions of cyclazocine and of the subsequent importance

of this observation,

your participation.
I hope

I have changed

the authors to reflect

this meets with your approval. File copies are enclosed.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

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                    <text>January 26, 1968
Dr. Bernard Swerd10w
336 Third Avenue
Long Branch, New

Jersey 07740

Dear Dr. Swerdlow:

Enclosed are some of the rating forms which I d1str1buted
lecture last year. as weli as two in use in our c11n1c.
which may be of interest to you.
1n the

Thank you

for your inquiry.
Sincerely yours,

m.
um

72a»

A
.

Fink, M.D.
Professor of Psychiatry

Max

vary!»

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Dr. Harris

Lexington. Kentucky 40506
Dear Dr.

acetylmethadol or compounds like
Many

sir—v4-

thanks!

Fink, M.D.
Professor of Psychiatry

Max
r2.

”nun

it?

Sincerely yours,

4-

w

lsbell:

In the course of our studies with addicts we, like others,
have tried methadone maintenance. In a communication from
Dr. Paul Blachly, he indicates that you have had experience
with acetylmethadol - "slow dope." Can you tell me if your
experiences have been reported? what is the availability of

7-

wy'rvvwrm-u

Isbell

Professor and Acting Chariman
University of Kentucky
College of Medicine
Department of Medicine

MF:kp

�</text>
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