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                    <text>'II-vx'vvbwv'Vtga

.-

hay 23, 1969
Dr.

Kjell

Fuxe

Karolinoka Institute
Dept. of Histology
Solnavagen l
106 01 Stockholm 60
Sweden

Dear Dr. Fuxe:

Enclosed is a cOpy of the report of the symposium
"Experimental and Clinical BEG" in Liege. Would you

please make any corrections or additions which you feel
necessary, and add relevant citations using the same

style that I did?

The corrections
directly to:

and

citations should be sent

Dr. G. Verdeaux

Centre psychiatrique Sainte-Anne
Laboratoire d'E.E.G.
1, rue Cabanie

Paris lée

75

France

I was very much impressed with your theory of dapamine
and noradrenalin sensitive systems for the neuroleptice.
I hope I quoted
correctly.

it

For many years I have been interested in the convulsive
therapy process. Some time ago I summarized the biochemical
evidence for cholinergic mechanisms and attempted to relate
the changes in EEG and behavior to the little biochemistry
that I could find in the literature. I am taking the liberty
of enclosing a copy of that report and would like to ask your
comments regarding the following questions from your experience:

for ECT for
any of the neurohunore similar to that
which you presented for the neuroleptice?
Is there

m:
.x
-'
V

'F‘IM‘

Jewry

‘waywx

1%)»?me

““3"!”

any evidence

�May

~2—

Dr. Fuxo

Can you

recomnd

any

23, 1969

additional

workers or references regarding the
cholinergic mechanisms or other

nonrohunornl mechanisms which may be
involved in induced convulsions?
Do you have any theory of the
mechanism of convulsions from a biochemical]

pharmacological point of

I

would

like very

much

that when noxt you are in
so that I can arrange for
Many

View?

to continua our discussions and hope

New

York

that

you

will let

you to meet some of

my

no know

associates.

thanks for your participation in our seminar.

Sincerely yours.
1m Fink, 111.1).
Professor of Psychiatry
Mfzkp
‘

.

,
,

fanny-r,-

emu,

~

~v

V'ngmiﬂmuw

534491

‘1'“?

7.1;..:q,7h~,,..,

,.~,:.vv.

\
ﬁ

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"A"

fury-r53

�</text>
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                    <text>May

T0:

23, 1969

Dr. Borenstein
Dr 0 Dongle!"

Dr.
Dr.
Dr.
Dr.
Dr.
Dr.

Itil

Longo

Hellerio
Nequet

Peepiglione

Titece

Enclosed is a copy of the report of the symposium
"Experimental and Clinical EEG" in Liege. Would you

please

make any

corrections or additions which you feel
relevant citations using the same

necessary, and add

style that I did?

corrections
directly to:
The

and

citations should be sent

Dr. G. Verdeeux

Centre paychietrique Saints—Anne
LGbOtBtOira d 'EoEoGo
1, rue Cebuaie
75

Paris lee

France

that it was a great pleasure to participate
I look forward to each of you visiting
in
when
next you are in New York, hopefully
my laboratory
the
International EEG meetings in San Diego.
immediately after
You

must know

these sessions and

my

best regards.
Sincerely yours,
Fink, 24.x).
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>i «g. u

1-

7.,

mm,

m—m-w

,-.

... ,.

qmn—~

.15..

r—Iw

«r mm.-- (.wv"
-

May

w

"wru—"'I&gt;‘anv~-:l-—xm

..l~

w, ..

.7

..

v

'«77 Wﬁ—vrver—«yvv1

24, 1969

Dr. William.Tabor

A. H. Robins Company
1407 Cummings

Richmond, Virginia
Dear

Bill,
I

have just returned from a very intereating and useful
to
Euroye to find that our studies have gone ahead. Our
trip
first patient on AER-1900 is now receiving 7.5 mg per day.
Because we are keeping the patients on a placebo period of 2
weoka, I will need an additional 10 x 50 capsules placebo for
ARR 1900. The label is attached.
As you remombor, we have maintained two

patients

on

butaperarine elixir and we would like now to transfer them
to tablets. These are not available in our formulary and
I have taken the first step for their approval. In the
uaantima, would it be possible to make 500, 5 mg tablets
available? If this request is not appropriate for your
office, should I call Mr. Corners or is there another

rapresentative

who you can have

call

on me?

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MP:kp

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                    <text>May

24, 1969

Dr. Eva Kellerova

Bratislava, Czechoslovakia
Dear Dr. Kellerova,

I have received the kind invitation of Dr. Formanek
to participate in the 8th Interdisciplinary Conference on the
Study of Higher Nervous Functions in Marienbad October 9~ll.
I would be pleased to participate and am prepared to discuss the

topic:

Quantitative EEG and Human Psychopharmacology:
Theory of Classification of Psychoactive Drugs

It is impossible, however, with the present limitation on the
use of 0.8. funds for foreign travel to pparticipate without
support for travel to Eurppe from the host country. If that
can be arranged, I will be pleased to participate in this
important Conference.
Thank you for your kind invitation and I look
forward to meeting you in Marienbad.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Division of Biological Psychiatry
New York Medical College
5 East 102 Street
New York City, 10029

U.S.A.

�</text>
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                    <text>g

.- “" .
‘

v-

rum-w.vawmway—we'rwmqumv-Wrw

"“‘ “4."‘ '

“

.

V

,--&gt;,

‘

,

”H

"'17
r .,.

V'WWWL'WW‘FW“

23. 1969

Dear Milt,

May

Tha Program Committee

of the

1970 CIR? met

in

Roma

on

6/7 and discussed the suggestions for symposia and lectures as

presented by different delegates and members. All the suggestions
of

made by myself and the Czecha were turned down by the majority
Tha suggestion of a symposium on EEG models in
the Committee
drug evaluation was also rejectad, and no EEG program accepted.
3

The principal foci will be on neurohumors (including
alleged naurohumnrs), lithium and amphetamine addiction.
we

will

U.8.

Y

Thank you once again for considering my suggestionw~ but
have to find ancther forum. perhaps another society in the
my

E

wr-P“

'

May

P

vwvu—v—ywv—wwrw.wnun_

__

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

m!

vu'A‘AV‘JWV-iwr«mum—m..-

‘

v

‘

-

Mm: magnum-'—

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                    <text>Msy

25, 1969

Dear Alex,
By now you should have received my note shout my
visit to
Athens and Bro. Mites and Stefania. The remainder of my trip was
as interesting, if not meta so, than tho first part. The meetings in
Liege were exoellent, with some presentations by biochemists and
pharmacologists from scsndioovis that were relevsny to our interests.
Much of the emphasis was on dopamine and noradrenalin, however,
,and in one discussion, when I asked about the role of acetylcholino.
I was told that it was indeed important but that the absence of a

suitable biochemical assay bed limited the studios to the oeurohumors
that could be studied easily. (Thio was also stated by Dr. Eunnoy of

EIHH who

spoke

at our College this post week.)

I so still interested, however, and so taking the opportunity
to enclose coma reprints of my studies. It seams to me that the
convulsive therapy is the most specific and the best treatment of
severe depressions in men; and that the study of its central effects
should contribute so much or more to our understanding of deprassion‘
as the study of other oeurohuoors affected by imipramino and MAO inhibitors.
In my earlier review I was impressed with sostylcholine, but this
may have boon related as much to the available studios so to any
relevant theory. The same study should be applied to the other
ooutohumors, especially oorepinsphrins and dopamine.
are treating ospreseive patients with induced convulsions,
and bilateral elect rode placements. There are
significant differences in EEG and in memory effects of the two types
of treatment, and while those may be principally matters of degree rather
than kind, it does.provide tho oppoortunity to study two éiffetent
CS? psttsrns. we should be able to obtain CS? before and during the
treatuont process.
We

competing

unilateral

‘

.

Have a good time in Greece. It is possible, though remote.
that I may be back there in August. so pleaoo send me your Greek address.
If not, perhaps you will write when you return to Chicago sad we can

discuss thui further.
Agsin,

my

thaoks for your

»

hospitality.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>May

25, l969

Dr. William Bunney

Clinical

CenTer

NlMH

5454 Wisconsin Ave.
Chevy Chase, Maryland
Dear Dr. Bunney:

Enclosed are The reprinTs we discussed on Friday.
enjoyed your visiT very much, and wish To congraTuiaTe
you on The fine program which you and your associaTes are
I

direcTing.
May

i

suggesT you

also

Thumb

Through The volume,

"AnTicholinerglc Hailuclnogens," vol. 28, Eisevier,
Magma in Bum Rumch, I068.
My

besT regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry
Mszp

A

y.”

A

.V,

,

pun—WU.”

cﬂwrmmu—wmp

”.1341

“urn-war

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                    <text>n.
;

w

m-

r-vrmvm—w.u.w....,u

urn—arm

a-rsw

mun-w

g

May

26, l969

Dr. Barry Blackwell
The Wm. S. Merroll Company
Clnclnnafl, Ohlo 452l5
Dear Dr. Blackwell:

pleasure to dlscuss our drug ovaluaflon programs
recon?
moeflngs of lhe Soclofy for Blologlcal Psychlafry.
during fhe
Whlle we have underfaken many cllnlcal drug Trlals ln psychotlc
and nouroflc subjecls, we have found These of less relevance To
our eventual appllcaflons Than our EEG sfudles which show
Interesting predlcfablo relaflonshlps. Unfll we have exhausted
our lnlorosf, we are devoflng our prlnclpal cllnlcal enorgles
to comblned EEG¢¢llnlcal frlals.
l?

A

was a

sample profocol and some relevanf roprlnts are enclosed.

If fhese mefhods lnforesf you, would be pleased #0 have
vlslf our laboraforles To dlscuss your compounds.
I

you

Thank you

for your lnferesf.
Slncerely yours.
Flnk, M.D.
Professor of Psychlafry
Max

MF:kp

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                    <text>“mm...“

r.

.,:mew~uw.«

:r-w

r'

amt-"W9"

“mi-«M

«awn-r

w

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_.
‘V‘WV
,

.

.

, «Ur—"VW1-

_.—,,‘.H,..w-au...w

May

wu—ww

26, l969

Dr. Maurice Dongior
Dept. Psychologio Medicaio
Ed de la Constitution l53
Liege, Belgium
Dear Dr. Dongler:

pleasure to work with you in the meetings in
want, once again, to thank you for your hospitality.
Liege,
On Friday, i sent the preposed summary of our conference
that you send your comments
to oach of the participants and asked
discussions most
to Dr. Verdeaux for integration. i found our
we
interesting, not because we disagreed, for i don'tin believe
viewpoint.
disagree about the facts, but for the difference
recent
few
of
reprints
my
a
of
enclosing
i am taking the liberty
mental
of
illness
of
the
diagnosis
which review the literature
at
using neurophysiological criteria, and my own efforts
Antichoiinergic
(Eds):
Fink
and
classification. (See also: Bradley
Eisovler,
Hallucinogsns, vol. 28, Progress in Brain Research,
i have enjoyed
because
View
is optimistic
l968.) Perhaps my
discard
was a
itand
i

come to
the benefits of quantification of EEG and have
of inadequate
because
studies
most of the available psychiatric

design or measurement.
look forward
and in New York.
i

Again,

my

to continuing our discussions in

San Diego

best personal regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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-

May

26, l969

Dr. Enoch Cellaway
Langley

Porter NeurOpsychletrlc Clinic

40l Parnassus Avenue
San Francisco,

California 94l22

Deer Noch,

This year

i

have been

particularly fortunate

in having

three resident fellows who have made outstanding contributions
to our research programs. One, Dr. Michael Taylor, is assigned
to the naval base at Oakland Naval Hospital and has asked me
to write to you, in the hope that you may assist him in continuing
his research interests. Or, lacking that, in studying with you
while in the service.
Dr. Taylor and his co-worker, Dr. Robert Levine, have
Just received the A. E. Bennett Clinical Science Award of

the Society for Biological Psychiatry for their study,
"The Interactive Effects of Maternal Schlzophrenie and
Offspring Sex". A copy is enclosed. They have continued
these studies and have more data, all of which is still
consistent!

introduced them to Reece Jones in Miami. i am asking
Dr. Taylor to call you when he arrives this summer, and l
i would be peeased for him
commend him to you most highly.
academic
in
an
career once his service is over,
to continue
and have indicated my willingness to have him rejoin my
staff if he wishes.
l

My

best regards.
Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
Mszp

—

d

thnwcthx‘

w.

P.S.

have recently completed a paper on the mathematical
analysis of the pentothel response which we have Just
sent to ScLence and which i think will interest you.

We

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                    <text>May

Elsevier Publishing

P.0.

Box 211

26, 1969

Co.

Amsterdam

Gentlemen:

I as writing with regard to

subscriptions to
journal,
unfortunately, may have become
confused. I have subscribed to the Journal since its
inception, and my present subscription seems to have termr
inateé with the last issue I received, that of February 1969.
The subscription was to have been paid by my College and
the

EEG

perhaps

to

my

which

this has been

two

a confusion-

I also requested a second subscription addressed

office, for the use of

my

laboratory

staff.

This

also to have been paid by the
College, has been paid, but the subscription has not yet
subscription,

which was

begun.

,

_

it be possible for somewone to check our
and send me a note which would permit me

Would

subscriptions
to establish these subscriptions:
1.

Fink, M.D..
Arleigh Road

Max

39

Great Heck,
2.

New

York 11021 U.S.A.

ﬂex Fink, M.D."

Department of Psychiatry

Rev York Medical College
5 East 102 Street
New
New

Thank you

York City 10029'
York, U.S.A.

for your efforts.
Sincerely yours,’
Max

Fink,

M.D.

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                    <text>May

26, l969

Dr. Jerome Levlne

PsychOphermacology Research Branch
NlNH

5454 Wisconsin Ave.

Chevy Chase, Maryland

Dear

Jerry,

Since our discussion of The chlorpromezlne blood levels
and
measures, l have had an opportunlfy +0 discuss #he
proposal shortly wlfh Sam Gershon and at greefer length wllh
Dr. Julius Korein. From befh, I found the expecfaflon The?
the bgggd levels should correlate wlfh The EEG signals. This
Ian ¥9§8$8 unfounded.
8§Bec
EEG

sfudles of biodd levels and some
measure of brain function, and in each fhe correlaflons are
poor. This is usually "explalhéﬁ‘68i°+hﬁlpbaeiﬂdgohefhe
m“'Kb‘l'here have been many

in sﬂﬁdlbs El
barrier'.
if is possible to malnfeln

Héﬁfofhal anasfhesla,
a steady blood level,
EEG
shows specific sequences of changes which
and yet the
are correlafed wllh The subjecf's aneslhellc slefe and nof
with The blood level (raulconealumbsmelzm; 15: 3m, I952).
In a
of cﬂéggdlazepoxlde Whlfmen and Sfern found no
sludé r5981»
ills $5858 WNW antnnahrepol-ted
t8l'l‘8‘t3ﬁ
oﬁhdlllﬁeOEEGtehahgeughel are
laahdc‘l"52¢
'blood—breln
for example,

studyii“6l‘3a‘i‘ll

levels for
with
§¥Bhl8
b18§*
i9 fheﬁﬁlood

+

r

53'”th

a'lenfs receiving bulaperezlne.
$3oT°E§cqeiﬁﬂine, was There a
Phleptadgluﬁcmmdesem mauve

oﬂiég183%.:
mean
W
' EBBMH
3%fqﬂl8lvlnfﬂdﬁhﬁﬂﬂﬁlﬁﬁﬁbwwwmm
ill-rilllsl'lﬁhg
wwmmgmumsemm
3+ Wd’gﬁlﬁ’ékhhb
Selﬁsulﬁﬁm
ne‘lWWWuehmeH-Ipmou
twin
wallow“)

5%
(Ella ggé‘ianl‘ls‘l ko‘ﬁrgiﬁbqe

will

'lrbl’l‘d'lﬂ’llll?

W‘eTLWEEG’WIWW quﬁﬁlum
Wivewmbsmﬂe .EE0 “1993“” Mel-8 bummed

pe ;egzeq on; woe; coLelnpgA'
bee; oxboLgouco ga ena+olusq)‘

suh Loggegoue Mill pgAe so
+pe ebeC4g4goue
pe nulnlellloq §OL pgoloﬂgcg; Legaoua (1;
Qu+gc1bg4e eye;
euq anLegA he can bLOque ¢pe EEC weeanLee'
plooq IGASIQ Ml4u pSpSAIOL suq M1;p o;peL dnou;149;ghe wegenLoe‘
monlq p6 bleeaeq 4o boL4gc1bg4e gu suo+peL a4nqh leg4gua
msA

Quq

g

3

BL. 16LOW‘3 rel/HUG

—Sa

INS-1A

‘9‘ '695

�,

.

".smwW

—,,.——....—._'....--y——~-«—..—.—w..-.——v—w.vu“,r»vrﬁ..¢_—w—7.-~..~wlv-—.,_N.V.——w

Dr. Jerome Levlne

-2—

May

“m..- {~__,,,__‘_

w

26, I969

I would be
pleased to parflclpate ln anofher study relating
blood levels wlfh behavlor and wlth other quanflfaflve measures,
and surely we can provlde The EEG measures. l anflclpafe That

expecfatlons

The

may

be

unfulfllled for blologlcal reasons (If

pas? experlence ls susfalned), and any relaflons wlll have *0
be leased out mos?

carefully.

'EEG measures were provlded
W'héWPaﬁlw
Mkmﬁﬁawémmm mammw
8"! 89‘ Waffle) {JedWEﬁé‘aﬂﬁgﬁl’gédmlhuﬂon
Wmdvgmwgnmmwm

M'
'EWWMW
8H9 ssnsulhlmlﬁlél’df

0113*}?

magma?

g 43% glam”?
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2%

$ W8
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$8W§38H§Uie87l§9f8u
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Am: we mom lane! (henlcoueslmmwswagg; 13: 291‘ was)‘
9L9 COLLsgeLen ng4p lpe anpleclaa guealpellc 24949 guq um;
guq he; ;pc 559 apome abecg41c aedneucea o; cpguaea Mplcp
40L exgwbje‘ 1; ga boaalple +0 mg;u;sgu g a;equ pgooq [BABl‘
t,)(x;;t:oq-—pm:1u ngLleL‘;
é” engage; 9* H§E*o4p9| 9u924peegg‘

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l? "angll

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‘

we

meeanLe o; pngu *nuc¢gou‘ Qqufgiegcg+ﬁgg 232:2?nggta 9L6
MF3kplpeLe peAe pee” umuA 24nqlee 04 ploqq {9A8}? guq aowe

“34933 nugonuqeq'

ﬁéGC‘iééau
fehega eponlq COLL6|946 A1+p 4pc EEG
p
4p

egauspa' Luz?
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bLoboae| apou4|A All“ 39w eeLapou guq 94 aLeeleL .gua;p ﬁlly
guq gge wesenLea‘
pghe pgq gu obb0L4nu14A 4o agacnaa ;pe
gluce OﬂL qgacnaegou o; lye cpIOLbLouexlue pgooq |eAela

DL’

!

QGQL

19LLA‘

cpeah cpgee‘ Wthleuq
QVQV

Mth

MlBCOUElU VAG'

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DL' 1eLowe FGAlUG

BLQUCp

wall

59‘ 1595

wvw

—.

�</text>
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May

26, l969

Dr. Maurice Dongler
Dept. Psychologle Medicaie
Ed de la Constitution i53
Liege, Belgium

'

Dear Dr. Dongler:

it

was a

Liege, and

I

pleasure to work with you in the meetings in
want, once again, to thank you for your hospitality.

sent the preposed summary of our conference
to each of the participants and asked that you send your comments
to Dr. Verdeaux for integration. i found our discussions most
interesting, not because we disagreed, for i don't believe we
disagree about the facts, but for the difference in viewpoint.
am taking the liberty of enclosing a few of my recent reprints
which review the literature of the diagnosis of mental illness
On

Friday,

i

I

using neurophysiological

criteria,

and my own efforts at
and Fink (Eds): Antlcholinergic

classification. (See also: Bradley

Hallucinogens, vol. 28, Progress in Brain Research, Elsevier,
l968.) Perhaps my view is Optimistic because i have enJoyed
the benefits of quantification of EEG and have come to discard
most of the available psychiatric studies because of inadequate
design or measurement.
i

and in

look forward
York.

New

Again,

-,
'
"

L

my

to continuing our discussions in

best personal regards.
Sincerely yours,

saws-W

:ts-rimm-nww

:

Mex

4:

wr

rymzrarrr'ﬂr

Mszp
gamjzkmf

“,3,

_.
-

'.
'.

a-zng:w.-v;rrmwrwmmn

magma.

Hun

Fink,

M.D.

Professor of Psychiatry

1;.

San Diego

�</text>
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                    <text>J's Uw-va'rwt'evx- «mm.

‘VV—WK,"""\'W

aura-rm

—-

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v

erm'ﬂ’lW'Il‘AvrqvnwmAm-xw'VWWrw-vnwl‘wrrﬁ'nx-Ynuww- . uv-WV—

May

——:~r.-v

,.-

1‘.

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v

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26, l969

V

.‘_.4_

,._.._

Dr. Barry Blackwell
Wm. S. Merrell Company
Clnclnnatl, 0hlo 452l5
The

.r.——,,....,

rev,

..

Dear Dr. Blackwell:

lt was a pleasure to dlscuss our drug evaluatlon programs
durlng the recent meetlngs of the Soclety tor Blologlcal Psychlatry.
Whlle we have undertaken many cllnlcal drug trlals In psychotlc
and neurotlc subjects, we have found these of less relevance to
our eventual appllcatlons than our EEG studles whlch show
lnterestlng predictable relatlonshlps. Untll we have exhausted
our lnterest, we are devotlng our prlnclpal cllnlcal energles
to

comblned EEG-cllnlcel
A

"w

trlals.

sample protocol and some

relevant reprints are enclosed.

”to

.v“,

“FEW.

.«mg»..,.,.

you

lf these

vlslt

methods

lnterest you,

I

would be pleased

our laboratories to discuss your compounds.

Thank you

for your Interest.

y—my—

Slncerely yours,
Kev»

Vv-I-‘T

mm

WWW:4:

aw"..-

\w

'va

vr‘l-wv.

“NH-J

m
‘

Flnk, M.D.
Professor of Psychiatry
Max

to

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.... . m-

.

..

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v

.n

.

�</text>
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                    <text>May ‘26,

1969

Dr. Bug-m 8. PW].
Assistant Professor

You

How

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06519

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Pennsylvania Psydﬁm‘ic
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�</text>
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                    <text>Dear Mr. Glickman,
The program

Medical College had

in the study of opiate addiction at the

its inception in

1960 with

New

the opening of

York

narcotic

a

treatment service at Metropolitan Hospital. Since that time, various
treatments and have been assessed, icluding psychotherapy, social
and group

therapies, therapeutic

community,

Abuse Study center was created (under the
Brotman) and

etp.

special Substance

A

direction of

Dr. Richard

this unit has studied’the sociological aspects of

substance abuse, contributing to the understanding of the typology of

addicts, the spread of addiction

A

in the schools and campuses, etc.

Beginning in 1965, a specific study program focussed on the
use of pharmacological treatments was developed, following the K/

legal

and

ethical breakthroughs initiated

by the ¢¢ pioneering

U’

of Drs. Vincemt Dole and Marie Nyswander.

We

efforts

undertook studies

of methadone, and when other substances for the treatment of opiate
WA‘AC/forzy?
4‘35”»! that ’0 j' "",
Z
Hf'znd
decided
the
to
assess
merit//bf cyclazocine,
role
addictioZ:
__

6!

it

naloxoneq tybamate/l 49 £4L§(:%/ﬂ“‘:zaﬂiw\’- ?
With the

assistance of the

Commission, the City of
we

New

New

York State Narcotic Control

York and the National

have been able to assemble azgxnnpzaf

r!(&lt;.u.(ra.ﬁ

Institutes of Health

/

scientists interested in opiate

addiction and are carrying out a variety of studies.

Some

have already

been reported, and copies of those summaries are enclosed for your

informationiilht present,
a

group, and onpther
'gESnp has been

based

22

we

9

patients in our out—patient
The

out—patient
iWad-v
,lr-L-Du/{Jiﬂ

limited largely by our inability to/éstablish

titles:

77

-"

35/

a community

and rehabilitation.

Ihe studies in progress

the following

60

in the in—patient center.

facility for aftercare

5LWw4 /

are treating

are—meny—aad may

be described under

of

Duration of antagonism to heroin £9 chronic oral
5?

methadone; Specificity of antagonism to heroin of naloxone; Duration

�action and

oﬂ

c
.

/

7L!

”44"! 41ij

,4

”11/.
.

r,"

linical efficacy of naloxone in/opiate addictiOH;
I

Comparison of the

CNS

effects of opiates

and

antagonists;

addicts: Significance for therapy choice in

Typology of

cyclazocine and methadone treatments
Application of tybamate in the barbituarte withdrawal syndrome
‘ﬁaﬂy—

Behavioral and

EEG

effecst of marijuana

ﬁmd7d.ocwa5M

and $3336.?

Behavioral effects of chronic marijuana use
measurable

Is there a/withdrawal

phenomenon with marijuana use

?

I trust this will be sufficient to give you an overview
of the programs. The Director sf—the-pregrams

is the Professor of

Psychiatry and Chairman of the Department, Dr. Alfred

JM

M

M.

Freedman.

M4Qp4nnkfmwu¢ian_ismthatxe£ Project Director and Director of the Division

M

.9

442111

of Biological Psychiatry/eé—éhe—Depertment*Uf—Psychtatryu——l—wéll—

enquiries, —altheugh—éf—yeu—énﬁeﬁé—ﬁewVISit
dwgyéa7-{ﬁ Zirit$‘-’M :1
“cote.
made

be pleased to answer your

W

Our—eeatery

it

would be was: useful for sash—arrangements to he

stethe—éémE‘that Dr. Freedman is available.

Sincerely yours,

ﬂee
o”...—
.1

9MI

WWI: "

-

c! f Ila/Z
{-4 (Via-(f?
exfidg.
,
(,7

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                    <text>1-5.

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27, 1959

May

Mr. Dmald S. Glickman

Legislative Budget Analyst
State of New York

The Assembly

Albany, Nae York

Beach. Glidenm:

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Wt

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                <text>1969 </text>
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              <elementText elementTextId="38698">
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            <elementTextContainer>
              <elementText elementTextId="38702">
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              <elementText elementTextId="38703">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>May 27 ,

hp. Charles Shagass

1969

Eastern Pennsylvania Psychiatric Institute
Remy Ave. and Abbottsford Rd.
Philadelphia, Pennsylvania 19129
Dear Charlie,
Al has just amnoanced that you will be lecturing on
June 6. I am very disappointed that I will not be here
as I will be attending the ECDLU investigator meetings
in Waslﬁngton.
Two

Czechs have joined my

staff

and

I

would be

for you to get to 1mm than. Dr. Jiri Roubioek and pleased
Dr. Jan
Volavka both know your work and if you have the tine, they
would be pleased to take you to lunch.

I an enclosing a copy of a report that we have just
oozpleted on pentothal. If you have a chance to read this
before your visit, perhaps you would care to discuss your
suggestions with Dr. Feldstein.
I

am

terribly sorry, but

other soon.

My

best regards.

hope

that

we

will get to see each

WW

Sincerely yours ,

r—rm

Fink, M.D.
Professor of Psychiatry

Max
mmywmvvv-w"

MF:kp
upwwm

,2
.Hrm

a

.

”ﬁg“:

"7.-

v

«urn;

mug-Ma

5M,”

r».

co:

Dr. Roubicek
Dr. Volavka
Dr.

Peldstein

�</text>
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              <elementText elementTextId="38688">
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              <elementText elementTextId="38692">
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                  <elementText elementTextId="102942">
                    <text>Hay 27, 1969

Dear Dick,

It was nice to receive your letter and it aoonda as if
achieved
less than you had hoped for but more than most on a
you
European visit. I had the occasion to visit Alex Koreans: in Rome
last week and hie experiences match your own.
I called Dr. Wbrtis, so you requested, for we had not
heard about your report. The volume is no longer being published,

instead the Society is issuing a new journal, Biological Psychiatry,
is to come out six times a year. The first ieaoe is now
in distribution (it was exhibited in Miami early in May). He said
that the paper has been accepted by one reviewer ("high marks") but

which

the second has not yet returned the menuaeoript.
I am sorry
that we are caught in a bind, in the issuing of a new journal. And
Joe wortia is not the most efficient of editors. I would suggest
we wait another month; and if you do not hear from him by lune 15,
I would write to him (or, better, call) asking the status again;
and if he gives you the usual doublewtalk, perhaps you should
consider publishing it elsewhere.

is foousoed

more on neloxone (how long
by increasing the
single oral dosage) and on methadone (how long does the usual
daily dose of methadone protect a patient against injected heroin).
and less on cyclexooine, although we have completed one essay on the
We are also trying
typology of patients who do well on cycleaocine.
to extend the duration of neloxone by embedding it in a plastic
polymer, like Sileetic, in the hope of achieving a 30 to 60 day treat~
Our program

can we extend the

antagonistic actions

meat.

’1 attended a meeting on peyohotropic drugs in Liege and met
a group of pharmacologist/ohemists from Sweden headed by Foxe of
Karolineka. They are doing fine work and if you do not know their
reports, perhaps you would look them up.
Keep up

the good work

!

My

beet regarde.
Sincerely yours.

�</text>
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              <elementText elementTextId="38678">
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            <name>Relation</name>
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              <elementText elementTextId="38680">
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              <elementText elementTextId="38681">
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              <elementText elementTextId="38682">
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              <elementText elementTextId="38683">
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  <item itemId="3867" public="1" featured="0">
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                    <text>hay 27, 1969
Dr. Oldrich Vina:

University
Biometric Laboratory
1145 Nineteenth Street, K.W.. Room 618

The George Washington

washington, D.C. 20036
Dear Dr. Vinar:

I have read the summary of tho CINP program and find
the report accurate. May I ask, however, that the title
usudly
The word "dependence"

is
of symposium 4 be changed?
without
argument.
not applied to amphetamines or hallucinogena
and
"Pharmacological
Perhaps the title should be changed to
abuse".
and
hallucinogen
therapeutic aspects of amphetamine
I note that your secretary has misspelled the cans
of Dr. Sarwer-Fonar.
I look forward to seeing

next week.

ﬂy

best regards.

you

at the

ECDEU

meetings

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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Dr. Joseph Zubin
722 West 168th Street
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Dear Joe,

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                    <text>May 27 ,

up.

mum: make].

Key

mt.

621 Dwal

Street
Harlan

1969

33mm

mm.m1:

Wlwbesynpaﬂnticmﬂnpoaitimmﬁchyou
mnemxding,1doobjwtintheuseofny0pinimin

thfuhimuhichywmmqmstim. Sinoemysmemnt
rm."

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Max

Mszp
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.,

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m1w*‘m'mw

-

1-‘1'

Fink,

M.D.

Professor of Psychiatry

«WW-nan

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                    <text>May

28, 1959

Dr. Norman E. Pitts. Director
Department of Clinical Research

Pfizer

Chen.

&amp;

00.. Inc.

Groton. Connecticut 06340
Dear Harman,
on
I have rend the Hurstorio. Msggini and Hurri report
Subjects"
"Effects of P-3693A on the Night Sleep of Depressed
with much interest, having heard this report in Spain but failing
it all
to grasp the significance at that time. I appreciate The
report
doxepin.
the more for having our own experience with
of
sleep
with
recent reports
is good, and the data is consistent
doxepin.
with
EEG in depression and with out experience

Despite the repetitious style, the authors describe disordered
frequent awakenings
sleep among their depressive subjects ~ with
A as the principal effects.
3
and
and decrease in percent tine stages
with high dosage doxepin, within one week there is a reduction in
awakenings and an increase in deep sleep. The increase in
REM~tine is unusual, though probsbly drug related.
These changes appear drug related. The adaptation after 2
weeks is a possible problem; we would have wished some data in

weeks 4 or 5 of treatment.

discussion in relevant. The authore‘ distinctions for
doxepin from other drugs, while possibly true, is interesting and
data
reportable, but I would hove gishsdggﬁerg ggrgpggrgzsecure
be
few
to
for antidepressants and BOT. “wheaggporgopsre too
definite, although the results parallel the findinge reported
on
here for doxepin.

ﬁhﬁkb The

impressed by the dasgycoadyxanAAggsk that the dosage
be confirmed (it scene high); that if any similar data for week
should be reviewed; and what subsequent
a orwi ﬁlelxléﬂahday
studies (with dorspin or other psychoactive agents) have the

I

am

it
ant-hm W Amarmmywqiommﬁm
Enema-(memes
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he:

of

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cpnubrapsmipnnprn nesg' gps qece or
I pens neceerq 1:1}.3 moron on

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Dr.

Pitts
Thank you

in our reports.

-2for sending no this paper,

28, 1969

May

which

will

bu

useful

I have received Itil'n notes

chnupununuugbnghﬁp week.

on CP 14-368 and will complete
The data of 8 patients in the doxapin

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or}
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�</text>
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                    <text>May

28, 1969

8m

I». Stm'txm

Gnme 8
Inc.
381 Park Avmue South
New York, New York

Dear Dr.

Strum:

Dr. Joseph Zubin suggested

for your attentim.

that I send mesa to you

Sincerely yours ,
Pink,
m
Secretary
HFﬂcp

MOD.

�</text>
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                    <text>May

28, 1969

Dr. Allen P. Berger
Associate Director

Pfizer

Chase

&amp;

00., Inc.

Groton, Connecticut 06340
Dear Allen,

It is

kind of you to

make

lithium available for our

clinical trials, and an FD 1573 is enclosed for filing.
I have asked Dr. Jovan Simeon to assume responsibility for
this project, and have submitted his curriculum vitae for
filing. If you wish additional curriculum vitae's,including
my own, we will send them as well.
arrange
If the protocol is agreeable, would you please
be
should
This
tablets?
of
1.000
send
supply
an
initial
to
sufficient to get the group started.
Our

other protocol is being sent separately.
Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>"ﬂaw“

w'wl'

'___¢_,_

May

‘

28, 1969

-~rv...-——W~ww&lt;-

aw,

mumv—

“WV"

““4

W"ﬂ)‘w~w‘nwﬂﬁ'ﬂl"ﬂa’ﬂuvw-‘y-erW‘WrI-r—v—ummmn-

Central
Central

Islip State Respite].

Islip, Hen

York

new Sid,

Immitingmmmﬂw.8eymmenpmis for
Wipinmmw. wmmnajoimminmmming
Ir.

Wis.

Inavemofhiawoﬁcformtiuebutmlyhmm
occasimtomthimsﬁneahejonmfmﬂty. Rial-«names
Whalmumxwdmhiamm
«retaliated, despite hm meant we. Hie interests in the
phmmlowofmtyldnlimmdotmbiogmicmat
ﬂmmlomlm‘levelmldamchprmiaeformundomtanding

mm

ofﬁmmdeofwﬁmofpsydwtiveagema,mdlrnpem
make
the work of the College.

will

sigufieam:

to

Sixwely yours ,

WWW-Jr

.V.

Mu...”

max I’

, £4.13.
Professor of Psychiatry

urn-:1

AWW'ETW!

@sz

.5._.

bcc: Dr. Bumpreis

�</text>
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                    <text>28, 1969

May
"r
:.

r:

‘wz‘u—t

"aw.

1-k

w
5

Dr. Mary A. B. Brazier
Brain Research Institute

University of California Modical Gunter
Loo Angolan,

California

90024

Dear Mollie,

Enclosed is a copy of a report describing a mathematical
approach to the EEG response of pontothal. We have workod on

this for

you

in

I

many months and you may

December.

would be very

recall

grateful for your

my

discussing

comments and

‘
.

My

best regards.
Sincerely yours,

3514“"‘w’ﬁ‘u'urﬁr-ran’wr";wu

Fink, M.D.
Professor of Psychiatry

Max

v?

getf-tﬂxku,

m.”

,.-

;

”W.

.n"

.n,_

wnwmamm'ﬁ-‘m

~.-.'"‘?w‘~s.‘;

4"

“-W-I"

‘Wﬂf-Wﬂv

4275'5‘

Mszp

with

criticisms.

H..-

m-

it

�</text>
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May

28, 1969

Dr. Strat’cm
Game 8 Stratum Inc.
381 Park Mann. South
New York, New York
Dear Dr. Strut-Cm:
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                    <text>May 29 ,

1969

Dr. Norton Miller

National Institute of Mental Health
5&amp;5“ Wisconsin Avenue

Gravy Chase, Heryland

Dear Dr. Miller:

I

look forward to seeing you on Thursday homing,
to be at no. Cohen's office at 9:30 am. As I
indicated, one subject for discussion is the possibility
and expect

of developing a long acting nsloame. Mover, the principal
focus of our meeting should be the possibility of a study
at the Urdvemity of Athens to determine the central nervous
system oranges, if my, of Chronic marijuana use.
I am enclosing copies of the mport that I submitted to

mm

Bar. Freedman on my
from a visit to Athens on May 8-10,
and a
of a. proposed project. It was the latter
which was the basis of Dr. ﬁeedman's call to Dr. Yolles.
I believe that such infomatim can be gained rapidly in
such a study, not only with regard to the patimts but with
regard to cooperatim of the staff in Athens.

mom

IlookfozwaxdtoseeingyoumJuz-nes.
Sincerely yours ,
Fink, h.D.
Professor of Psychiatry

Max

Wakp

‘
&lt;
.

gins“

-..-.aw:.m...,

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                    <text>May

29, 1959

Dr. Sidney Cohen

National Institute of rental Health
5451+

Wisconsin Avenue

Chevy Chase, Maryland

Deer Sid ,
Following our

dismiams of a

long acting form of

nalom,

Ihadocoasimtoepeaktorr. Waboutevieitthatl
had carpleted to the University of Mime. I suggested that
itwwldbevaluable toserdatemtoAtlmstoemdy this

years,
group of patients who have been taking marijuana for many
and to define, if poesible, the (magma of brain change which
my have occurred.

sufficiently interested to call Dr. Yolles;
the matter was referred to Dr. Filler; consequently, Dr. Miller
today suggestedthathe joinusatmmmeetingmﬂmday. I
amencloeingacopyoftheobeervatime as Importedthemto
Dr. Freedman and my menu: to him regarding a proposed project.
Time permitting, I should like to discuss a cmtrect for
amarijumastudyinAmem andacontract forthe studyof
nalomne in a eilastic vehicle to extem its duration of action.
6136' Separately, Dr. Preednm has written to you requesting
large scale study of the clinical,
m extentim for a proposed
CNS
aspects of marijuana to be mdertaken
logical and
in this laboratory.
yoreeeox. o; Lehcprgxzm
Dr. Medium was

1m

2.3.1110 II-I'D'

gruoemﬂx home '

more ens 911A bmpjeue) °
page“; euq any p6 erghmfi

to

94: 4:116 (316M (31926 pacer. 1-0qu II
a : 30 9131’ Jynmqgh (I MIN p6 mum'ﬁ was nrﬁp;
14: 3'00}? 3mm ms nigh game e pnel 110me
I 3'00}: Louver;

366211.13

DL' @3161!

hon

g;

-5-

gm sa’ Iaea

�-2-

Dr. Cohen

29,

May

1969

Itlodcslikewemayhaveabusymrrdng. Ilodcforwm

toaeeingyouatQ:30am,'nmsdq(Iwillbear-rivingﬂnnight

befmmwﬂlbostwﬁxgatmomumemwwdgaif
Wmmypmblm).
Sincerely yours ,

m
m. of Psychiatry
Professor
MOD.

1'”

M8

NPOUROIA‘

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wquwgmcmeqyuﬂcmaumozqn

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�</text>
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                    <text>May

Dr. Henry

29, 1969

Brill

Pilgrim State Hospital
Stanwood, New York
Dear-Henry,
Al has matched Dr. Yolles; Stan passed

to

Non:

Miller;

andIhaveadatetometNortMilleramlSidCohmon

TImday.

Ifthemammy hitcheslwill call you. Inthe
mantithavemtyetheardfrmDrJﬁmsbutwill
have
giveanymrmssage mmnday.

My

Enclosedisaoopyofnympomtobn.

best- regards.
My

W1.

best regards.
Simaemly yours ,

Fink, my.
Professor of Psychiatry

Max

�</text>
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              <elementText elementTextId="38542">
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                    <text>mung-n

uwr-rl/v'v

a...

n

-—.w'

&lt;

m».

:vnw-

m...

v:—

June 2, 1959

ﬂW:-Ww\m‘

-

Dr. A.

(5. Copper)

Clinical Investigation

Ward

of

Medical Resend} Council
West Park Hospital
Epsom, Smey, England

mm,
Dear Alex,

It was

a pleasure to participate in the GIMP program
I believe the final program to be a.

committee with you and
well balanced one.

discussed, I an enclosing, some reprints of our BCI‘
in 19 57 - the neuroxﬂiysiologim
available biochenzical—psydmlogic
data as well as the interest in psychologie neurohumrs. The
recent observations that drugs altering brain function can
directly alter psychologic mallards-ms lend more weight to the
first part of the theory and less to the second.
As we

studies.

The hypothesis proposed
adaptive - tried to encompass the

In 1959—60 I was impressed-Mitzi; the date of the olnljnergic
neclwxism and especially by the results of my studies with anticholﬁnergic drugs. Perhaps the same results could leave been
achieved with sympathondxretics (indeed, LSD did antagonize Em‘
produced EEG slowing) but I did not study them carefully.
men no

new

reassess the

301‘

date appeared

by 1965 I submitted the draft for
enclosed. Perimps it is time to
process with as web entimsiasm es sleep, lithium

publicatim, and a

copy

is

therapy and mnomnines have received.

Sincerely yours ,
Fink, Md).
Professor of Psychiatry

Max

�</text>
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                    <text>"W",

,

Wm.

-

June 2, 1969

W

Cmter
Parkinson
New York Neurological Institute
722 West 168m

New

Street

York, Hm York

mar Dr. Yahr,
'
'
pamiwlarly interested in the
effects of peydloﬁxemqueutio drugs , notably the neumleptics;
and the EEG and behavioral effects of mticholinergic drugs.
We

leave become

‘

Ihavebeenmfezmdtoymmmter,toeekfcralistof
be available
(PIG-Search?) which

reviews
litme
from your center. If such a list is publislwd,

available

may
may I

request a

www.mlreqwstnylabomomybepiaoedmyourmiling
list?

My thmka.
Sincerely yours,
Pink.
m
Professor of Psychiatry
MOD.

Hf‘ucp

Division of Biological Psychiatry
Departmmt of Paydﬁstry

New York Medical College
5 East 102nd Street
New York, New York 10029
.

�</text>
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            <elementTextContainer>
              <elementText elementTextId="38522">
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            </elementTextContainer>
          </element>
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                  <elementText elementTextId="105749">
                    <text>.

7. ..

.77...

,

.

.7.

W

“ms

7..

...,, .

i “m: .

«vy

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... (3' ___,7,.,‘ m... “av-.mvn—pvmm
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v. mw..~..r-w..—mu--w\

u—u-

KMVv-uw-V . w- “WWW“.

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w .~\.m-vw—~,.»v-‘—— www&gt;‘&gt;w'

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,7

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A

”m,

.v.

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1

i

i

E

t

E

June 2, 1969

E

l

i

I

E

S

E

E

Dr. v. G. Longo

Institute Superiore do Sanita
Viale Regina Elena 299
Rom,

Italy

Deer Enzo,

It was

a pleasure to mxk with you in Rome and Liege.
received the promsed summary of the proceedings

You have by now

E

E

E

i

l

_»

g

g

in Liege.

In our discussions with Alex, and in Liege, I was impressed
with the progress in the understmding of cmtnal neurolmnors ,
including the "Initiative" ores. For some tire I have been
particularly interested in the CNS effects of re .eted grand-—
mal convulsions (as in electroshock ﬂumpy [ECT ) when I
reviewed the available biodxemistry in 1959—60 and again in
1965 , I enpimsized dwlinergic molmisms because the data was
available; and because of my special ecperiences with anticholimrgic
drugs.

Isupposeoneomldnekeasgoodaceseforcentml
ECI’ as for dwlinergic. Perimps
the time is right for some ackiitional study, and I am taking
the liberty of sending some of w reprints in the hope that
their critique may become the basis
for dismesim.
I would be particularly pleased to have you visit New York
Bywaﬂxaninetic d'zanges in

m.

~«Mwwm‘.

.

this fall; and want to take this opportunity to them:

your hospitality.

“an

‘

‘

My

best regards .
Sincerely yours ,

rm Fink, 14.0.
Professor of Psychiatry

you

for

in».

.mwnww-‘

.

.

�</text>
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                    <text>June 3, 1969
137'.

Cosmo

Ajm Mar-am

Natimal Ins'tituteﬁ of Health
Bethesda, Maryland

Dear W.

20011}

W:

Imﬂymmmdesimtommtotkmmmsof

the Cawsmdamplemitoabidebymemles, trusting
ﬁxatﬁxecmzait‘tw willbeequally judiciom forallnwbem.
The mgm "2338 Changes of the Narcotics Heroin ma
,
He'dmdone" shmld be listed with the
PM). ,
J.
Mimic,
J. Volavka, PM)” A. Zeal-cs, HA). and A. H. Freeman,
Hub.

mm

The

report “Lib

Mas of Opiate imtagmists” is wiﬂximm.

Mummmysioalﬁodeloftmmkowmseto
Mum
is witrmn.
WW
Pentattml”

I mule: like to subatimte the 611610866 abstract ”EEG
Patterns as an Index of clinical Activity of Psychoaetivn Lungs"
by ﬂax Fink, PM}. md Daniel 1%. gimpim, D.Sc. imtaad of the
report "Mtitative 2136 Analysis of mug-Induced
in

mammas in Mm" by Pink,

ﬁaﬂcyoufmyourooopamﬁm.

“inﬂating WW8.

A1th

mu: Emapim.

11:11

Wheatwishesfwa

Sincerely yams,

rm Pink,

1M).

Professor of Psychiatry

�</text>
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                    <text>W

"W

v

weanww—J-w-

7.w_mnrwnw——vrvw—wmm

,
gyuguqmr

nun-

H“

_

...“

,,

,_

”no“.

I,

.v

J._

_

”...", mum,”

_‘..r v;

,1, w.“ ..i. ,V‘“.

.

W“

WWW“ ,mw-

.

...

W7-

.-

t

,, vul- Awm-‘m-q-

,m-rm‘m

-

'v

.

-: —,r..«-u-.—--

w;

~:

,-:

June 3, 1969
Dr. B. G. Caille

Phitre de

Redmes

du Service de Santa dea Armees
Chef du Centre d‘Etudes at de Recherches
du Service de Psychologie Appliquee
de

Arsenal

la Marine
- Tmlon,

France

Dear Dr. Caille:
had hoped to be able to attend your meeting, but find
that our funds for international travel are frozen. I am
saddened by the thought that we are unable to participate in
We

ymrfinemetingandoanmlyasktlmtifﬁmds caz'xbemade

available from your- crgmization we would be pleased to send
Dr. Shapiro or myself to present the work of this laboratory.

'wulﬁ'm

.wmm

n":

‘r‘c'x-n-

:rrr

Um

.‘Q’

It was kind of you to invite us and I trust that your
organizing committee may be able to assist us in this participatim.
Sincerely yams ,
Max

PM,

24.13.

Professor of Psychiatry
Hfzkp

”V.

..

V

-

,~-

“w“.

....

-

.

--‘

v

�</text>
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                    <text>W

Dr. Allen P.
Associate Director

(has. Pfizer

8

00., Inc.

Groton, Camecticut 0630.0
Dear Allen,
Enclosed is a proposed analysis of CF 115368. Instead
of the usual two-step, I am proposing a three-step study in
which the first few subjects will be studied in an Open
eituatim in order to determine dose - time relationships.
A defined Open study will give us the approﬂnate classificatim
and

this will follow Dr.

Itil's

reconnendatims.

If we

are

successful with both these steps , we will have the necessary
infometim to do a definitive classificatim study.
Dr.

Itil was most helpful.

If this program meets with your approval I would appreciate
a supply of 50 capsules (tablets) of 50 mg C? 114,368 and an equal

umber of placebo.

The study can be begun as soon as supplies

are

made

Sincerely yours ,

1m PM,

2". DO

Professor of Psychiatry

MFﬁcp

,

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«w

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.w

.

“r.

.
.

June 3, 1969

available.

�</text>
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                    <text>~._-.—,-.m—w- ,,.- 3:“-:v

.1"

L &gt;7.

xx c“.

.

vv¢-v.vwv-1~vuvw' -vrq—w;a..—r--rmr-.

~

gamma-um

-

~

“g

~,

w-w—r

m

7-7,

-

vw

we .Vmwwrn

&lt;

a—w—v

——

.m

v.wmww,.-

June 11. 1969

nwvlr‘r‘

.A-

m

..

nut-mm

Dr. Joseph Hortis
Haimonides Comun‘lty Henta1 Hea1th Center
4802 Tenth Avenue

Brooklyn.

New

York 11219

.

Dear
“rue—V...“

aw

m?

W

yw;vm-wwm.m—rnr'us—m

7mm“.

.Aer

u...“

v_,;.v.e

b'wv‘.‘

Joe.

report “The Cerebrai Reactivity Modei in Schizophrenia
Re-Appraisai' was not presented at the Society of Bio1ogica1 Psychiatry because we had not comp1eted the ana1yses in time.
It is un1ike1y that I wi11 have the paper ready within the next
few months and suggest that you de1ist this
report.
The

A

Sincere1y yours,

Fink. M.D.
Professor of Psychiatry

Max

rt _,,,_,,

wet-v

v

�</text>
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                    <text>June l2, i969
Dr. Thomas Williams

National institutes of Mental Health
5454 Wisconsin

Chevy Chase, Maryland

Dear Tom,
look forward to seeing you at Gracie Square Hospital
(420 East 76th Street) on Thursday, June l9, at IO:OO am.
i

Please

come

to the laboratory

Enclosed is a

the

first floor.

draft cepy of the report

the data until April
My

on

i.

which summarizes

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

fokp

�</text>
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                    <text>June 12, 1969
Mr. Robert L. Marlin

Sandor Pharmaceuticals
Hanover, New Jersey 07936

Dear Mr. Harlin:

Enclosed are two draft copies of our protocol for the
study of S 4-25h8, and a form FD 1572.

In the event this protocol

appreciate receiving 50,

2 mg

like
tablets are not available,

and a

is satisfactory, I

tablets (capsules) of

may

initial

S

-

"gr

Sincerely yours,

v'

.
—-l

-u'

.w

-;.V-.—

,r
v

_-

Pink, 11.1).
Professor of Psychiatry

Max

H.

1.2;“

,~
v.

,r
.-..

'

v

‘vxna...

'v-z'xaxxwwr

112m“

~15"-

wvw'."‘,"X7.nij'.:

MFtkp

4-2548

supply. If 2 mg
I request 100, 1 as active

number of placebo as an

and 100 placebo.

would

�</text>
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Office of Public Information’
National Library of Medicine
B¢thaada, Md/

Gentlemen:
my.“-

w.“

We

would appraciate engine of the following two

bibliographies:

.A.,;,.mw,y—nm.

3-69
4*69

PsychotrOpic drug addition or withdrawal symptoms

in

man

Cannabia toxicology

Thank you.

Sincerely ypurs,

Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>-r-'(~

...

m,¢:m"pr

w,

.1'

(1,1;

mﬂku;

F—uwv

June 16, 1969
Columbia University Praas
York City

Raw

Gantlanon:
Ha wnuld like to rocive a copy of the W80 Technical Report
#381, Neurophysiological and Behavioral Research in Psychiatxy. If

that: in a chargn,

we

wil; remit promptly.

Thank you.

Sincerely yours,

Max

Fink, 3.0.

Professor of Psychiatry

at]

�</text>
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                    <text>Mr" .

June 16, 1969
Committee on Brain Sciences

National Research Council
Washington, D.C.

Gontlenen:

Facilities

would appreciate a copy of the 1380 Survey of Research
and Manpower in Brain Sciences, as doacribad in a recent issue

we

0; the Mental Health Digest.
Thank you.

Sinceroly yours,
”may—'wW'i

Max
-73;

ka, rm).

Professor of Psychiatry

KC

m

(

‘.

X
a

\

r

a

in}?

G

a

l

.h
-.

Ti

,\\

�</text>
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                    <text>June 20, 1969
Dept.

A

Upjohn Co.

Inglewood, California

‘9

Gentlemen:

I would appreciate additional information on your new
program of Laboratory Procedures, as described in tho recent issue
of the

JANA.

Thank you.

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>June 20, 1969
Dear Dr. Boyer,
no are in the midst of an evaluation of the initial
pyrovalerone data and it should be possible to review this on
Friday. May I ask that you join me at my office at 5 East 102
at 1:30 p.m. ?

I look forward to your

Street

visit.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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              <elementText elementTextId="38402">
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                  <elementText elementTextId="102917">
                    <text>.7,,.,~-V....V.,.~.—.mmm‘

qmﬂmﬂvwaw-

~

.

..

u",
M
fF//&lt;(
I

fa

,1?”

/;JVL

Juno 22, 1969
Dr. Jo Dragoons

Jansaen Phnrnaooutica
Baotou, Balaton
Door Dr. Brugmnna,

R—6218.

Thank you for the dolcriptivo litoraturo on R-6238 and
which both my nusooiato, Dr. Jovuu Stucco and I havo road

much interest. The special nature of tho population for whom
pinoxido to rcoolaendod is clearly scatod, although the juatifioation
cacao-I on. Ruvnrtholoaa, we are interestad to those compounds, ond
I an writing to suggest that you visit those laboratories on your trip
to tho U.8., which you indicated would be focthconina at the and of

with

Mypmvmwwc:

m
‘

this

I can be roachad at my office most afternoon: (212-369 7900)
and would be plcaood to arrnoge to have you visit both our laboratories
and our clinical £3c111t1cn.
Again,

V&lt;'Q\'.

-

“7mm“,

month.

my

sections in Lingo,

thank: for your help in tho trunclattonu of tho
for the description; of pioozide and fluopirilonc.

and

Sinooroly yours,
Max

mf/

Fink, M.D.

Professor of Psychiatry

�</text>
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            <elementTextContainer>
              <elementText elementTextId="38392">
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              </elementText>
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            <elementTextContainer>
              <elementText elementTextId="38393">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102916">
                    <text>&lt;

n

w

w

Y,._..—»-v...r-—"4~wn‘

.

7

.....

2

“m w—

W...

,m.

«wrwvvmew—F

................................Y1kildliq33&amp;u3 3330nqqﬁ

eﬁz 30

ahrsbntjs as?

ion at jroqox std? :notouisqgg

03 qu

goljeovejnk aid: amines:

Try—r‘. -~.——»——.-—w—w——,&gt;.——_.

has 332

.lsnzuot

30

valnujroqqc ed:

103 uov

333

inng

June 23, 1969

.zboje anilq

Dr. Peter Kallaway

Baylor College of Medicine
Houston, Texas
Dear

Peter,.31unv vtexsonkl

I have read and re~rssd the article. "EEG and Hypnotic
Susceptibility"; and when my recommendations appeared imprecise, I
shared the report with my associates. Our conclusions are mixed, although
the recommendation is specific.
.W.V

ﬂirt? ts”

v133errmmect

is a

good one, and the problem important.

desire to relate a behavioral variable (hypnotic suggestihility)
with a quantified set of EEG variables is coeesndabls. hath measures.
that of behavior and EEQ are well selected, and seeaingly are the
most efficient available.
\lv
The

Negative: The attempt to relate an attitudinal variable
with EEG measures collected at disparate points in time has been
unenccessful in most studies; and when a relationship is reported,
it is usually not sustained in later studies. The best relationships
are those measured in close temporal relations-- the closer the better.
so

of

that errors

64 spa

due

The sampling rate is low: the filtering inadequate,
to aliasing are highly probable. (A sampling rate

leads to folding of

60 cps

in 3-5cps).

The Grass 3 dB

contribute to this difficulty and especially if the authors are
not aware that many Grass instruments bypass the filters for the
tape outputs. This should be enquired into in their system.

filters

Sample sizes are very small, and the use of means
spurious. What variability measures were used? Were split samples
(#5 vs £5. or 30vs30v930) assessed to insure that the variability of
these very small samples was not excessive ?

may be

Five significant measures of 96 (at a minimum) or
of 600 (at a maximum) are not impressive. Especially if they are
derived statistically and not from any theoretic point of view.
The absence

of a priori hypotheses degrades

studies, and I regret the authors did not choose to make their ideas
clear and test them. The statistical approach to science is very unsat~
isfactory.

«Wm-r

.—

�QMG
‘\~.

WMWt1¢samttbintyo3uoco39.303.3333333933313393...

6033133133: 11113

Journsl.

EEG

'Ihuk you fat

-

stat:

311°:

report

than

239: .33 sent

13,

no: 39 to

opportunity of

2

m “Mud. of

.0...

the

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                    <text>w

y1
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«.w,

waxy?

SCW-MIW

“Vivi“

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Juno

2’5,

1969

Soorototy

o! Roooorch rocilitioo
um annoy
Broio Bcioocoo

in

Notion).

lotionol

Mouth
Aoodooy

ﬂoohiostoo. n.c.

Council

of Sciooco

boot Giro:

hook you {or o copy at tho mo Botvoy of looootoh tocilitioo
ond Honpowot in Main Scioncoo. It io indood o moivo took. gonotolly
won. dooo, out o voluoo thot will hovo iuoodioto utility.
-

a

writing
io ooticipotod thoto oto oooo ottoto. ond I
tho out
to count oolo choogoo which ohooid ho incorpototod innow
York
tho
oditioo. I wito “cording tho oootioo doyotod to
hoodod
by
Llodicol Couogo. pogoo 213-215. rho fiool mogropho
"tho Btoio noooorch ..." contoio oooy ctroto.
Ao

Doportoont of Poychiotry. hoodod by A. ll. hood-on (Choinon)
(Editorial Boord. Anoticon Joutool Orthopoychiotty) hoo on oxtonoivo
lRho

in two
pronto: in tho tolotioo of broio function to hohoviot. dividod
N.
(
Pink.
principoi divioiono - tho Divioion of Biologicol Psychiatry
R.
B.
Ditoctot).
John.
Diroctot) ood tho ntoio Roooorch Lobotototioo (
tho Divioion of Biologicol Poychiotty io mootood with tho roiotion
of BIG chagoo ond hohoviot in non. opocificouy tho iotioonoocf

ioduood oonvoloiooo. poychotropic and holiucioogonic drugo. ond opiotoo
lobotototioo. coo with oo-iino
on no. no ﬁocilitioo includo thtoo
oooiyoio ooio; on Ila-1800 oyotoo; toot topo oyotono; and 25 bodo for
poychiottic tooootch. Tho ooiootioto includo Dr. D. u. Shopiro, cooputot

m

molyoio of biooloctric oignolo; s. Foidotoin, poyoholinguiotico;
3. Dornhooh. ooooty oochoniooo;
J. Volovko. nonotivo quootitotivo no;
H. Koolot. odvotoo offocto of
J. noobicok, BEG out! holluciuogooo;
hoilucinogono ood comb“; out! )4. Fihh (Ditootor) . quontitotivo
drug offocto. induood convuioiono. and hohoviot in poychiotric
m.
ouhjocto ond natal volootooto.

Division will mo to o tic-unity Montol Boolth Contot in
1970, vhoro opportunitioo to: ditoct clinicol - oourophyoioloxiool
otudioo win ho oxpoodod to o 50 bod rooootch unit.
rho dooctiptiono of tho Btoiu Roooorch Lobotototy oro oooontiouy corroct.
lrho

hook you for your cooporotion.
Siocotoly youro .

7123‘

“I",

“523:3!"

”C.

F
771.

I'm-mom»

Ho: Fink, 24.1).

Professor of Psychiatry

�</text>
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                    <text>June 24. 1969
Miss

Stockert. Chief Pharmacist

Monmouth Hedicel
Long Branch. New

Deer Hiss

Center
Jersey

Stockert:

Recently. I visited the Monmouth Medical Center on an
seminar. New aspects of the program were impressive.
but the most imdietely velueble was the up-toedete fomlary.
Our Formlery Cmittee has struggled with the need and
desirability for a detailed compendium of available drugs.
IBM

if a

recent

mny

ﬂaws.

we would be most

copy of the

grateful.

fomlery print-out is available.

Sincerely yours .
Fink. OLD.
Professor of Psychiatry

Hex

Hrskp

�</text>
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                    <text>December 3, 1968

Dr. Ted Roth-In
Rush Research Foundation
has Angelou, California
Dear Ted,

Fluphenazine

is the draft copy of the report, "Depot
Facilitation of Treatment of Psychosis", summarizing

Enclosed

the experiences with both long-acting depot forms, in Missouri and

in

New

York.

are pleased to have had the opportunity to participate
in your volume, and wish you all success in this venture.
We

My

best regards.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

MF/

�</text>
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                    <text>Jam 24.

1969

Mss Jo Hawkins
Associats Mmtor

Rush Rosssrch Foundation
9201 Sunset ma.
Los Angaiss, California 90069
Dear

um

Hawkins:

I have checked av ﬁles and ﬁnd author a letter to
Brinks!- nor a latter stating that I have made such a
roquss .
Dr.

Dr.

Enclosad 1s a

Maker.

letur

which I have Just sent to
Sinosro‘ly yours .

Has

Huh. ".0.

Professor of Psychiatry

�</text>
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                    <text>-;-w~u

June 24. 1969
'rw-w'nww-ur-pw.

Dr. My Brisker. Editor
Archives of Genera! Pa chiatry
Marian Medical Assoc etioe
535 North Durham

'

Guiana. Xiiimia

60610

Dear Dr. Brinker:

i as writing to request per-iaaion to republish a figure

aredinthemumaﬁw
thia figure in a emery of
mid like to mlude
ma «pot fiuphenuine which will appear in a

fmmofwreportawhicb
1
Pa

.
our expe emu
roiuu entitled
by T. Reuben

of

“Changing
Lou

Pattern: in Psychiatric Care“. edited

Monies.

have permission in republish the figure from the
Phenothiazine (Muphemine Decanoate)
articie
Treatment of Psychosis“ which appeared in Vol. 18. page 479?
Meg we

Long—Acting

Thank you

for your cooperation.
Sincerely yours.
ﬂax Fink.

"m'kf‘qaf

.

‘0:

ng-p-r-z-«yaw

cc: Ilia:

u.-,

Wy

.un

*7

"‘3‘”!

i=1"

Lv

«-w"‘?mW

..
7m

M

n
&lt;

1'5“"

mwe;£¥§

.

".0.

Professor of Psychiatry

:

Mina

�</text>
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                    <text>NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST lOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

RECEIVED

JUN

June 24, l969

301959

R. .W. MAYQ

Dr. Roy Grinker, Editor

Archives of General Psychiatry

American Medical Association
535 North Dearborn

Chicago,

Illinois 606l0

Dear Dr. Grinker:

writing to request permission to republish a figure
my reports which appeared in the Aachiveé 06 Genenaﬂ
Paychiatny. I would like to include this figure in a summary of
our experiences with depot fluphenazine which will appear in a
volume entitled "Changing Patterns in Psychiatric Care", edited
by T. Rothman of Los Angeles.
I am

from one of

May we

have permission to republish the

figure

from the

article "Long-Acting Phenothiazine (Fluphenazine Decanoate)
Treatment of Psychosis" which appeared in Vol. l8, page 479?
Thank you

for your cooperation.
Sincerely yours,
Max

ﬂ“, EMA,

Fink,

M.D.

Professor of Psychiatry

MF:kp

cc:

7x3

Miss Hawkins

PERMSSSSCN
UPON

swam

5,
cam-nan, CONTINGENT
APPROVAL BY AUTHDR.

JOHN H. TALBOTT, MD, EDITOR. JAMA

‘33

DR.TALBOTT
&lt;'

JUL 2

$5

‘9

3
‘33

§§¥ {Kg

bk
A

\

z\

�</text>
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                    <text>June 25, 1969
Dear Ernst,

There are only a few references 00 the

EEG

effects

of cannabis, and none recent. The most interesting is an unpublished
report by K. Miran, describing some increased slow wave activity
in chronic hashiah users. This will appear in the symposium on
marijuana edited by Wittenborn.

other reports are old and include:

The
Amen,

F.: J.

Ment.

Sol.,

1958, 104:972~999.

Williams, Himmelobach, Wikler, Ruble

&amp;

1946, 61:1059~1083.

Lliyd: ?ubl. Hlth. Repto.,

Wolstenholme, G.E. and Knight,J (Eds.): Hashiah: Its Chemistry and
Pharmacology. Little, Brown &amp; 00., Boston, 1965, 96 pp
has some

also wish to examine the LaGuardia report which
data (although poor) and the preliminary report by

You may

EEG

Hiklar and Lloyd in Fed. Proc., 1945, #:1él.

My own into is in progress; and I have recently analysed
tapes front Reece Jones at Langley Porter, but this data, too,
is incomplete.

some

You

will

be pleased to know

that I

a symposium on cannabis/EEG/psychological

am planning to add
to the next CINP meeting,
,

if my co~chairmon let me got away with it. If not, perhaps you will
present your data somewhere public so that we can discuss it.
It is

obvious

we

need more modern data, so good luck

I trust I will see

you in

California.

Have a good summer.

Sincerely yours,
Max

mf/

3

Fink, M.D.

�</text>
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                    <text>June 24 , 1969
Miss Jo Hawkins
Associate Director

Rush Research Foundation

9201 Sunset Bled.
Los Angeles,

California

90069

Dear Miss Hawkins:
I have checked my files and find neither a letter to
Dr. Grinker nor a letter stating that I have made such a

request.

Enclosed
Dr. Brinker.

is

a

letter

which I have

Just sent to

Sincerely yours .

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>June 24. l969
Dr. G. Verdeaux

Leboretoire a la Faculte
48, Rue de Grenelle (VIIe)

Paris. France
Dear George.

If three references are all that are required, please

ones marked on the attached xerox copy.
I hope that the summary
the completed manuscript.
I

was

trust I will see you in

use the

useful and I look forward to seeing

New

York

after the

San Diego meetings.

at my laboratories either Nednesday,
September 24. or Thursday. September 25. and I will write to you soon.
I an

trying to arrange
My

a session

best regards.
Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 24. 1969
Dr. Fred Clark

A. H. Robins Company
1407 Cummings Drive
Richmond 20. Virginia

Dear Dr. Clark:

In our studies of AHR-l900

we need additional supplies.
please ship us 500 capsules, 200 mg the an equal
number of placebos. Sample labels are attached.

Would you

Many

thanks.
Sincerely yours ,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>.w,

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Laboretoire e le Peculte
48. Rue de Grenelle (Vile)

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Deer George.
11'

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three references ere ell thet ere required. pleese use the

ones eerked on the etteched xerox copy.

that the emery was useful end I look fonerd to seeing
cmleted unuseript.
I trust 1 will see you in Na York after the Sen Diego
meetings.
I en trying to errenge e session at my laboratories either Hednesdey.
September
the

I how

My

“‘3

24. or Thursdey. Septeeber 25. end I will write to you soon.
best regards.
Sincerely yours.

m:wr1rzbemrsrrw'm'

‘
-

'

Hex Fink. NJ).
Professor of Psychiatry

"

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                    <text>June 24. 1969
Dr. Gaston Castellanos Villages

Instituto Nacional de Neurologia

Insurgentes Sur 421
Mexico 7. D.F.. Mexico

Dear Dr. Castellanos-Villegas:

After our pleasant meeting in Liege. I had the
fortune
to be discussing our studies of cyclazocine as an antgood
depressant
with Burtrun Schiele: and he told me of your interest in this
problem. Trusting that your interest has been sustained. I an
enclosin draft copies of the report we recently submitted for
publicat on. He found cyclazociee to be a useful antidepressant even more active than ieipreeine. although its narrow therapeutic
range will undoubtedly hamper its clinical use as an antidepressant.
You nay know that we came on the antidepressant activity of cyclazocine
from its EEG profile. A copy of that report is also enclosed.
"5““

'0

rurmﬁ-ﬂ:

interested in holding a meeting on the general
w th the World
subject of EEG and psychiatry in conjunction
Congress in l971. As it wil take some planning and support
will have to be obtained to finance attendance by some participants.
I am writing to ask whether such a meeting can be considered in
your plans. either as part of the con ress prograe or as an affiliated
meeting. If affiliated. I would be p eased to try to get the
sponsorship of some international research groups. as the International
Association for Psychiatric Research. or IBRO.
I an most

Again,

it was

a pleasure to hear of your

If the opportunity presents for you to visit
pleased to arrange a visit to our center.
Hy

interest in cyclazocine.

New

York. I would be

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

r
w

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r
was-drum

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~.»

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enc.

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‘m-VW'W' .— "‘W' ww—

Wmn‘w'w-“m

v

Tum“ mm: :Wm/N-

.

wan-

E

E

5

March

3, l969

Dr. G. Verdeaux

Centre Psychiatrique Sainte-Anne
l, Rue Cabanis
Paris XIV, France
Dear Professor Verdeaux:

for

if

As I

returned from

a 2-page

abstract.

my

It

holidays, I found your request
is enclosed, with my apologies

the delay has inconvenienced you. A shorter abstract
was sent in December, and this will replace it.
As you suggest, I will be pleased to
present our
computeerEG data, but most usefully in the framework

of our present operating theory.

I look forward to working with you, and thank you for
kind
remarks. we have learned something since 1961 and
your
I trust the meeting in Liege will permit its expression.
My

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max
MF : kp

�</text>
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                    <text>W‘

waver”.

‘

,

,

-

V

‘1',

March 1:, 1969

Dr. Jamathan 0. Cole
Superintamlem:
Boston State Hospital
Boston, Nasaadmsetts 021%

Sear Jmathan,

mud

ﬂue
kind 911mg}: to
been.
This
has
canvulaive
ﬂ'larapy.
new for a manual of
cqnplataa and I am enclosing acme copies for ymr use. If
to make whatawr
it is aatisfactm, we amid be pleased
max-ants are necessary to run off my copies you may

may

mmﬂ'za ago you were

need .

a mthesiologist who is able to
Mt
manage complex convulsive therapy cases. I would mcmnj
You asked

W. Frank

22.

Wmn,

(212 875-5636).

I trust this

W6 East 88th

manual

Street,

New

York,

is Emlpful.
Sincerely ycnm,
Max

-

.
-

"HV‘V'T

MI?
V-IWJAz-n'

m“

A

7-m'rrf4

an...-

,.
...

my...»

at.

mme.w

wmmmmwzw

.,

Fink,

£41.13.

Mfeasor of Paydliatry

m-w

:kp

New

York,

v

FW/Jv'wnz-uyuw Jul-In~

W

�</text>
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                    <text>March

4. l969

Er. Fritz A. Freyhnn
St. Vincent's Hospital
l53 Nest llth Street

new York, new York lUOll

Dear

Fritz,

It

was kind of you to participate in our resident training
program. The residents, as well as my staff. enjoyed your
discussion very much, and I hope that we will have an Opportunity

to continue this type of dialogue.

With reference to your letter about the APPA, I share
your feelings. In addition to the suggestions in your letter,
which are important procedural changes, I think we must_rsappraise the role of the members. The younger members are
discourages from submitting titlns, for they sons know that the
programs are dictaﬁndle. Our sense of participation is
frustrating and the only connection between ourselves and

the society is an identification with the leaders. Since
these change annually, there is little time for them (or
ourselves) to develop the relationship which would encourage
participation. No organization has over succeeded in maintaining

its

membership when

it has

been autocratic.

Another aSpoct is exposure. The present ways of advertising
the program soon to be inadequate to achieve the kind of attendance
that we wish. This, despite the fact that we had more than lOO
requests for programs prior to the meeting. The subject was an
important one, the sneakers were excellent and yet, as I look
back I would admit that I contributed little to a successful
public presentation.
Perhaps

it

would be useful to most

discuss these ideas.

My

host regards.

at your convonétnco to

Sincerely yours,
Fink, MOD.
Professor of Psychiatry

“3X

,ME:kp

�</text>
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                    <text>Ham-h

s,

1989

Mr. R. Keith Carmen

Btewtivc Secretary

Canines

on

Problm of

Drug Dependence

Natimal Research Cumcil
Division of Medical Sciences
2101

Constitutim

Avenue

washingtm. D.C. zone
Daar Mr. Carmen:

at

Enclosed are the final copies of three reports presented
the MAS-ERG meeting in California for your midemtim

for inclusion in the

mittee.’

Thank you

1969

mm of the proceedings of the
'

for the opportunity to participate in this meeting.
Sincerely yours ,
Fink, rm.
Professor of Psychiatry

Max

�</text>
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                    <text>March

I».
;

a,

1959

Leon Eiserbez‘g

Department of Psychiatry
Harvard University Sd'xool of k’adicine

‘

Bostm, mssacmset‘ts
Dear

um,
Cmgrmlatims

of this Associatim.
and would
My

on your electicn as Vice President
I would like to make up rm: statimery

mists your preferred address of mead.

‘

best wishes.

Sinmly yours,
Fink,
Secretary

Max

MFsz

“1"

£1.13.

in

�</text>
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                    <text>I

l
I
E

P

x
x

March 7 , 1959

Dr. Helen

:3.

Wt

Associate

Kaplan

meesscr of

Psydmiatry

of Psychiatry

New York Medical College
5 East 102m Street
New York, New Yam 10029

Dear Helen,

thoroughly deligl‘lted to have the opmrtmnity to
prepare a sectim on "EEG in Psychiatry" for the. second
edition of the Commehmiue Tex/time}; 05 PA gravid/Ly.

I

am

I

assume

that the dates for this material am

as the section
My

best

cm

”Ccmmters

smci

Paychiatzy."

the. same

team .
Sincerely yours ,

.we

"-4,."

.r-

Yrs-mu

Fink, PM).
Pr'ofassor of myCMatw

ﬂax.
m1!"'wfwwwvv

‘lllrw'zm'rv—xwrv-

urn-

“W'l

-r

wmu-mv

:

W,“

mwﬂwmv'm

v-nw

HF :kp

�</text>
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                    <text>Mann 7, 1959
Dr. Arnold

J.

Mamiell

Departmnt of Psychiatry
Hunm Behavior
Sdmcol of Hedicine

of California,
Wimity
California

Irvine,

and
'

Irvine

Dear Arnold ,

for your letter of Febzuary 21, indicating
two
abstracts for the Society of Biological
of
acceptmoe
am
delighted that two of my young associates
Psychiatry. I
able
be
will
to present their musual work on "Effects of
Thank you

Maternal Schizophrenia on Sex of Offspring."

I am writing, however, to ask if it is possible to withdzm
the papa "Cerebral Reactivity Model in Schiﬂamrenia A Roappraisal". Some of the work whid'x I, had wished to include
has met unexpected difficulties in the analysis and neither
Dr. Itil nor I think that we wand have sufficient mterial
available by the end of May to justify the presentation.
I regret my inconvenience that this my cause you.
Thank you for your indulgence.
-—

Sincerely yours ,
1% PW, MOD.
Professor of Psychiatry
Ifzkp

�</text>
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                    <text>Earth
Dr. {Bert

J.

13., 1969

Sici‘mllex‘

Assistant Clinical Research Bimctor
The. Squibb Institute for Medical Fﬁsam
New Bmmswiok, ﬂew Jersey 08903
Dear Dr. Schuller:
31-15:ka

you

disthinuim

study period.

for your inquiry regarding; the reason for
depot f1uphenazine in 22 patients during a
'

Fifteen {wtienta were disomtinued ltuecause of failmr'e
to keep appointmen‘m; of these, tl‘m'ee were imaznvec} , ten were
unimpmvec‘; and We had complained

of secondami effects .

Eight mtiemts cut of the fifteen haﬁ remix/12d l~~2
injectims mly, and. the regaining seven patients received
34»? injectt'ums.

patients were dischemg cm transfemed to other
fm‘ﬁf‘ﬁeatmnt by the ﬁnerapist; of these, two refused to
continue treatamt, time had secondary effects , mo of which
war»: hmyﬁtalized by other doctors , cm was; heapitalized fem
alcoholism, and another one was hospitalimd became of the
severity of his mmtal ccmditim.
Seven

.3

fmm patients were hospitalized. MG patients
were disomtinued because of toxic effects or physical

In

total,

mlicatims.

Sincemly yours ,
nun-wyww;

mu

.
r.

v

mm’w‘nmJ'l—Ir

Ptofessor of Psychiatry
Mszp

�</text>
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                    <text>9:20:

,Ei new?

~S-

eta todﬁ .ytncnded

Yntnom txen
‘

10d5T ~13

ni vines tnemtniodqe noedonul woo beaaim on
edt pnitub todteoot pnittog to daemon: ed?

etuov
'

Y

ieweonia

March

i3, i969

Dr. William R. Tabor
Director, Medical Regeprohpygn x3e

A. H. Robi

sh

.

to ﬁoaaat01q

i407 Cummings Drive
Richmond, Virginia 23220

e#:3M

Ogﬁﬁwgﬂkﬁrsneod tauL asd ybute Devi—HHA edt not lsvonoqﬁ .B.q
nice 25 thee ed biuoda betaengua useWetpdt‘emtot edT
ii)as ‘l‘ybamate
paper on Drug Dependence:
haymgymigyed
the galley proof on the tybamate report from the Joannnﬁ 06
Clinical Phaemacotogy and have ordered 300 reprints for our use.
if Mrs. Corneal would like to order an additional supply, please
have her call my secretary.

(2) Buteperazine Syrum Study: This study has appeared in
Canaan: Thenapauxic Reaennch; however, we have not yet received

reprints.
(3)

AHRleDO: With regard to Mr. Banner and the City of
York with regard to AHR-IQOO, i called him and he was
principally interested in a general statement about AHR-lQDO.
After our discussion he indicated that he would approve this
study. He was surprised by the request from the Commissioner
of Hospitals, indicating that this was the first such request
that he had received in twenty years. We have three patients
on the ward now and we are training our staff using butaperazine
(which is apparently quite successful). l anticipate no further
difficulty in obtaining approval and believe it should be forthcoming shortly.
New

Fenfluramine Exhibit for

APA: i regret to tell you that
called the exhibition manager of the APA he indicated that
we were much too late to apply for space, the deadline having
been January l.
am disappointed and accept the responsibility
for not anticipating this deadline. As thought about the kind
of exhibit i wish to make, it occurred to me that we might try
such a display at the forthcoming international EEG meetings in
San Diego (September l4-20, i969). if it is successful there,
perhaps we would like to use that material for the APA in l970.

(4)

when

i

i

i

�"WWW-1|

W

v—w

or, Tabor'

wva—rw

~2—.

"

'

March 13, I969

.

We mIssed our Innehson appeInfmonf

early In February. Wha1
1he chances of
1ogether
durIng 1he nex? mon1h?
go11Ing
H

are

SIncereI y y ours ‘

eaex .EI 131m
'

1odsT .R mmIIIIW .18
Max Fl ngﬁawgeﬁ IsalbsM 30139110

Professor of

'

1

.

Hngp

9.3.

va1G

agnImmuO

‘

-»

ApprovaI for me MIR-2900 sway has Jus‘I‘ been
The forms 1ha13:!en su osfed shauld be193q°5q
n1 93
wedge.

MW}Md
an 3nnnuot 9d? mo11

-A

VOA!

_OS$E§ sInIg1IV ‘bnomdaIﬁ

_

.

'009 H

FGVENWS}
‘

no
ma
9d1
no
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11oqe1
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..

March

,
.,
~

l2, l969

imm-

..

—'wq,w.m

”a.“

It'guvwl'Vm'

mr

Dr. Oidrich Viner
The George Washingfon University

Biomefric Laborafory

ll45 Ninefeenfh Sireef, N.W.,

Room

Washingfon, D.C. 20036

6l8

Dear Dr. Vinar:

Affer

to

yesterday my secrelary reminded me
The defes of the American Psychlefric
Associalion meefings (May 5-9, Miami Beach). These are among fhe
mos? useful meefings of our colleagues.- l fhlnk you would enjoy
affending The meetings and l am sure fhef Dr. Lehmann and ofher
American members of fhe CINP will probably prefer fo effend.
l

spoke

The? May 6 and 7

you

are wifhln

is There still lime To arrange fhe meefing of fhe Program
Commiffee +0 follow The conference on neurolepflcs in Liege?
sure

if necessary,

you

we can forage fhe APA meetings, buf
will agree fhaf affendence at bofh may be more

I

am

profitable.

4"‘v'rvlk

if if is possible for

w

m'r

w

"Winn-I4

you

to visif us,

Roubicek and Dr. Volevka will Join

inferesfing.

me

i

am

sure Professor

in making your

Sincerely yours,

vomA

erw-vmz-zaw

Jun-or

Fink, M.D.
Professor of Psychiatry

Max

Mszp

vlslf

-~

~-

unvr-rr

um

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r

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,

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�</text>
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                    <text>w-V'r‘

w‘vy‘. Immnn‘fw'".

WWVNK.A

~

March
Mr. R.

a.

Sfar Roufe

l3, l969

Mannlng

Soufh Plymoufh, New York l3844
Dear Mr. Mannlng:

spoke #0 your wlfe l? was To lndlcafe fhal we have
had dlfflcullles ln obfalnlng supplies of marljuana for research
do
purposes. Whlle l would like very much To have a supply, we know
Thls
already
Perhaps
you
no? have grant funds for
purpose.
fhal The Naflonal lnsllfufe of Menfal Healfh has announced +he
believe
esfabllshmenf of a few growlng confers for marlJuana.
The
To
of
rho
mee?
needs
sclenflsfs.
They wlll affempf
When

I

I

Thank you very much

for yourlnferesf.
Slncerely yours,
Max

Fink,

M.D.

Professor of Psychlalry

MF:kp

�</text>
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                  <elementText elementTextId="102895">
                    <text>March

l3, l969

Dr. Jerome Levine
Psychophermacoiogy Research Branch
Naflonal lnslifufes of Menfal Heal+h
5454 Wisconsin
Chevy Chase, Maryland
Dear

Jerry,
Our program MHel3358 (Quantifefive

EEG

Sfudles in

Psycho—

pharmacology) is now in ifs Third year. The annual renewal '
date is January i. As of loday we have no? ye? received The

letter for

award

MH~l3358~03.

have checked carefully within our adminlsfrafion and
have been reassured The? we have complied wlfh all fhe
requirements set forlh by lhe adminisfrafors in Washington.
i

am unable +0 utilize The funds in resfrlcfed calegories
wifhouf lhe leffer of award, would be grafefui if one of
your adminlsfralive asslsfanls could look info This for me.
As

i

I

Many

Thanks.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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              <elementText elementTextId="38152">
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              </elementText>
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          </element>
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              <elementText elementTextId="38153">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102894">
                    <text>March

Professor C.

l3, l969

J. eras

Deparfmenf of Biological Chemlsiry
Universily of Alhens School of Medicine

Goudi, Alhens, (609), Greece
Dear Professor Miras:

Since your

lefler of January l0,

i
have had The
*0
number
of
a
people in Washinglon
speak
opporfunlfy
New
and
York regarding a sludy program in marijuana. if
is our infenflon #0 apply To The Public Heailh Service

To

for supporf. There are aspecfs of these sludles Thai
’besf be done in associaflon wilh your laboratories.
For This reason,

i

vislf

would like To

may

wifh you in

i will
be
presenl if is possible
April or May.
in Yugoslavia a? fhe end of April (24-26) and could vlsll
wlfh you lmmedialely lhereaffer.
if i am no? successful

AT

In making fhis frip,
mid-May and would plan
I

+ha+

will definlfeiy be in

to visif wilh

EurOpe in
you aboul May 20.

Are eiTher of lhese periods agreeable?
you as soon as my plans are crysfaliized.

i

will wrlfe

To

are very much lnleresfed in obfaining some addlflonal
and was pleased To read fhaf you now have 2 grams.
Would if be possible lo reserve a+ lease one gram for our
We

THC

use?

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychialry
MF:kp

�</text>
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                <text>mfp-05-00-023-2-205</text>
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              <elementText elementTextId="38142">
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                    <text>"‘r

vw

ew—

mvmn—w-«wv;

-rr~v-

mum-

Knvﬂwv

ww.w~v~wwmmrrmv

March

l3, l969

Dr. Charles Shagess
Eesfern Pennsylvania Psychiafric inslifufe

Henry Ave. and Abbotfsford Road

Philadelphia, Pennsylvania l9l29
Charlief

Dear

’

Enclosed are Two Copies of The reporf which you requesfed
”Long~AcTing (Depot) Phenofhiezlnes in Emergency and Mainfenance
Therapy of Psychosis." I believe fhls states The mos? qualified

opinions and is fully consistenT-with our experience and fhe

literature.
i

Trust This us useful.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF: k5

�</text>
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                    <text>March

l3, l969

Dr. Alaln Sanselgne
Squlbb International
909 Thlrd Avenue

New

York, New York l0022

Dear Alaln,

Enclosed ls another report whlch was requested and whlch
should appear In a book edlted by Charles Shagass.

ulsh you would get a publlshar and
Lulgl Buccl would feel fultllled.
l

My

edltor so that

best regards.
Slncerely yours,
Max

Flnk, M.D.

Professor of Psychlatry
Mkap
60C .

�</text>
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                    <text>r‘

WWW-r

WW

—:r.--&gt;- -»

- ”-rv‘r'ni-‘Il'rv'

«u

T'w-va-rmx‘y,

.,

..

‘__

_.‘..

,N, ,.

,

March l3, l969

Dr. Hudgon Hoagiand
222 Maple Avenue
Shrewsbury, MassachuseTTs 0l545
Dear Hudson,
Thank you

The manuscrist abouT sex—raTio and
your commenTs. The daTa are small and

for reading

schizophrenia and for
require furTher duplicaTion and eiaboraTion and we are proceeding
wiTh Two proJecTs - one To repiicaTe The flrsT sTudy and one
To predicT The sex of

picTure.

offspring

based upon The maTernai

clinical

ThaT The preposed hormonal mechanism is speculaTive.
ThaT
The
clinical Trials ciTed in The manuscrist auggesT
However,
The adminisTraTion of TesTosTerone or progesTerone can enhance The
TherapeuTic effecT and decrease The relapse raTe from ECT. Torghele's
successful TesTosTerone-ECT TreaTmenT of chronic, Therapy—reslsTanT
schizophrenic women furTher suggesTs ThaT These hormones may
affecT The psychoTic process.
I

agree

difference in produchon of TesTosTerone and progesTerone
and female feTuses ls a crucial quesTion. WheTher
male
beTween
The difference ls in amounTs or in funchonal achvlTy of feTal
TesTosTerone or in The feTal meTabolism of placenTal progesTins
To androgenic forms is noT yeT known, buT such a difference
would indeed sTrengThen The argumenT. The possibiilTy ThaT These
hormones may affecT The chromosonal DNA codons in The defecTive
parTiculariy inTeresTing,
offspring (all defecTs were in The CNS) isinTellecTuai
funcTion
of
increased
DalTon's
reporTs
in View of
of
progesTins
dosages
received
high
moThers
in children whose
in The early pre-parTum period.
The

The quesTions you

raise should

sTimuIaTe Taylor and Levine

in furTher invesTigaTion and They and l Thank you for your Time
and commenTs. They will be presenTing This daTa aT The SocieTy

of Biological PsychlaTry in
This furTher aT ThaT Time.

May

and

i

look forward To discussing

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry

Mszp

wwmm,

-

van-'ervv

414.”

�</text>
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                    <text>m.v""“"'lVVW:M‘I—V

2mm”

”3,“

.

vv—

. “7”,”... w. _v: P.
,1.-n.. on
i

“W".

,

m.

' .1.er ~_W(‘V-v_‘ﬁ“-r‘q¢f‘t.w723W~A-Q'H5'1‘I-"l1i'u'v1rW-vr‘I

43‘".

r

.w-me—.
,

h

—

Max saw.”
v.

or

F‘upn‘“mn,y rum-aw.-r*-.-w-v.-.1-—vv~...r.-._-lv.,

v“.

,r

March I3, l969

"Ana..."

-

n...

Imam...“

M4,.

i...

Mrs. Tess Lindgren
CounTy of Los Angeles i969 Grand Jury
_

548 Hall of JusTica
Los

Angeles, California 900l2

Wasp-"MW-

«hum-u—

sm’g‘rvv

v

Dear Mrs. Lindgren
Thank you for your leTTer of February 5. Our sTudies of
marijuana began in November l968 and we have no conclusions
or daTa which have been published. One suggesTlon ThaT we do
have for a group of clleens like yoUrself comes from our

personal experience.

became inTeresTed in marijuana research in
lT Took us more Than i8 monThs To obTaln The
May I967.
The facT ThaT
supplies Through legal channe s - This despiTe
New
York.
marijuana is indigenous To The sTreeTs of
research
To
make
The
ThaT
encourage
clTizens
can
efforT
Any
raTher Than placing obsTacles in lTs paTh would be commendable.
We

flrsT

,n,

Sincerely yours,

,...,_x

m

“to

Max

1"WW'I-mm-n-n-v

mm-m'wwh

'h-N-vv‘r'v‘n,

v

‘,

“Wm-am":

‘r/vvvrm‘r‘i

Fink,

M.D.

Professor of PsychiaTry

wwwmawmwm-"im—

MF:kp

TV.

v

w.” w.

,

�</text>
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                    <text>,

—_

“.77... m:

.

,N—

n-

,

nun-m7. y

‘

7m“... "w.

“‘

WWW -lnnanpwuwwqua—warm

March
Mr.

Porlo

New

York,

Chief U. S. Chemisf
64| Washingfon Sireef,

|

New

York

Room

.

’17-“

-

W‘s—w

~_-

~

..

”ﬂung—w...

l3, i969

l003

Dear Mr. Porlo:

Following my discussion wllh Mr. Tagley of The
Federal Bureau of Narcotics, i am enclosing +wo samples
of presumed narcotic subsfances confiscaled from paiienls
admiffed to our deparfmenf during The pasf monfh. i
would appreclale an analysis for oplaTe subsfances (heroin).
We have been Told ihaT lhe malarial may haVe been cu? wifh

procaine.

Sample

capsule.

3/l is

in

silver foil; sample 3/8 is

in whife

Sincerely yours,
Fink, M.D.
Professor of Psychlalry

Max

Mszp

�</text>
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                    <text>March

l3, I969

Dr. Jona‘l’han 0. Cole

Superlnfendanf
Stale Hospllal

Bosfon

Bosfon, Massachuseffs 02l24
Dear Jonathan,
The speclflcaflon of magnellc tape system described by
Ernesl Harfmann ls compaflble wlfh our SP-SOO, for recordlngs
made a? 7 l/2, 3 3/4 and l 7/8 Inches per second recordlng

speed. These speeds are Idenflcal fo fhose available to us.

3

The maJorlfy of our lapes are recorded a?

3/4 lps.

lee

Ernesf

my

l

7/8 and

has? regards.

Slnceraly yours,
Max Flnk, M.D.
Professor of Psychiatry

Mkap

�</text>
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                    <text>wmtwwvn-

.nvvm-m-m‘

.wvn.

March

Dr. Karl

M.

l3,.l969

AlJian

Department of Medical Services

A. H. Robins Company
l407 Cummings Drive-

‘

Richmond, Virginia 23220

Dear Dr. AiJian:
i
i

have

must apologize

Just returned

‘to find your

letter.

for not having

answered you sooner but
from a vacation and professional meetings

to your question of ophthalmologic studies on
chronic butaporazine patients, l regret that systematic
ophthalmologic studies were not done before or aftér butaperazine
therapy.
With regard

‘

in reviewing the subjective complaints and symptoms of

our patients

who

have received or

are receiving butaperazine,

blurring of vision was a complaint of one patient and this
,improved aftor reduction of dosage. My associate recalls two
other instances of blurring of vision which was transient without
3
change of treatment.
‘

Despite specific inquiry,
ocular symptoms or signs.‘

my

associates recall

no

other

there are four patients receiving
butaperazine for periods exceeding one month. if it would
be of some merit to have you examine these patients, i am
sure we can arrange this.
At the present time

Thank you

for your inquiry.
Sincerely yours,

vamp-van:

1,.)

Max Fink, M.D.
Professor of Psychiatry

Mszp

�</text>
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                    <text>NB... “Tami/r».

r" ..

..-=-,..~

...,.,,,,....,

31T.,._w,rr.l "Weary...”w

March

my?

V

l..

,

.... p,“ mew—WT

~

V,

_.

,

V."

a

.,. m. .... .,

l4, i969

Dr. Jack Pefer Green
Chairman, Departmenf of Pharmacology
Mi. Sinai School of Medicine

New

York,

New

York

Dear Dr. Green:
Bofh Dr. Shapiro and

very much enjoyed our meeting
Perhaps There will be programs of common inferesf
hope fhaf we can work fogefher when necessary.
i

wifh you.
and

i

am enclosing some of The most recent reprinis from fhis
iaborafory. if fhe problem of anficholinergic drugs is of
i

parflcular inferesf, may recommend Volume 28 of
(in Bluuln Ruecvwh, Antichou'nugic iiawanogem,
i

Pnognebb
which i

edifed wifh Dr. Bradley. This volume contains addlfional
reporfs espetcaiiy focussed on this sfarfiing group of
hailuclnogens.
i

will be pleased

a? your convenience.

To show you Through our

iaboraforles

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlalry

MF:kp

,g or

�</text>
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                  <elementText elementTextId="102886">
                    <text>March

l7,

1969

Dr. Jerome Levine

Psychopharmacology Research Branch
National Institute of Mental Health
_5454 Wisconsin Avenue
Chevy Chase, Maryland
Dear

Jerry,
Thank you

of award of

MH

for your efforts

13358-03 arrived

behalf. The letter
this afternoon.

on our

it

is probable that the delay was occasioned
the administrative practices of this institution. 1
As

have already informed our Dean of the

trust

that the

Your

same problems

difficulties,

will not recur.

assistance iS-appreciated.
Sincerely yours,
Fink, M.B.
Professor of Psychiatry

Max

MF:kp

by

and,

�</text>
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                    <text>t

March 20. 1969

Dr.

Irvine Page, Editor

Modern Medicine
4015 N. 65th Street

Minneapolis, Minnesota 55435

A“-

Dear Dr. Page:
sew-,mvwniww

.-~‘n...~

-&lt;-‘—"ur‘r."n.

Your

editorial, "Further Evidence on Methadone and Criminal
is commendable in its recognition of the contributions

Addicts"
of Drs. Dole and Nyswander to the treatment of this problem.

Further data now available, and not included in your summary,
support your recognition.
Dr. Dole has reported in the successful teaatment of a
group of involuntary. incarcerated criminal addicts - a group
heretofore considered completely untreatable. (Presented at
the MAS-NRC meeting in Palo Alto, February l968).
In our independent study of opiate antagonists, we have
used methadone maintenance as our "standard” treatment. The

treatment is highly successful with a negligible drop-out rate.
Expansion of this program has been limited only by our desire
to continue our exploration of alternate treatment models,
notably cyclazocine and aaloxone. and not by any difficulties
with the methadone treatment program.

interested in knowing that Dr. Efren
Ramirez has left his post for reasons that are undefined,
described unofficially as disenchantment with the results of
Finally,

you

will

be

his program.

Your support of Drs. Dole and Nyswander

commended.

is

welcome and

Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

Enc.

�</text>
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                    <text>March

214

,

1969

Captain Lessmrd

Brnoka Air- Pome Base

Texas

Dear Captain Lenard,
have read your abatmct, "Studies of Ran-Crossing
Information of Sleep Em" with great interest. If a copy of the
report may became available, my ammciatas and I would appreciate
We

the:

opportmity to read
Many

it

in detail.

thanks .
Sincemly

Max

Fink,

yum ,

£4.13.

meaeaor of Psychiatry

�</text>
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                    <text>March 2a, 1969

Dr. mar-1. Dewan, Ph.D.
Redford Air Form Base

Massachusetts

Dear Dr. Dewan,
have read the abstract of your presentation at the
EEG: by conputeﬂ
,
with great interest . If a oopyoof the report may become available ,
my associates and I would appmciate the opportunity to mad it.
We

latest sleep mting, 'Nonlinaar analysis of the
Thank you

for your cmpemtim.
Sincerely yours ,

Max

Pink,

M.D.

�</text>
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                    <text>March 2a, 1969

Dr. Burt Schiele
Department of Psychiatry
University of Minnesota
Mixmeapolis, l‘ﬁnnesota
Dear Burt,

I have just received the

1969 program

of the

American

announcing the
Society of Clinical Pharmacology and Chamﬂmerapy
know
we are
You
report of cyclazocine as an antidepressant.
read a copy
to
Is
possible
data.
very much interested in your

it

of the data tables?
Many

thanks.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 2a, 1959
11‘. O.

Vinar

The George Washington lkxiversity

Blane-trio Laboratory

11% Ninetemth St. , NM.
Washington, D.C. 20036

Dear Dr. Vinar':
The reprint you requested is enclosed. It was a
pleasure tometyouandyommwife inthia coxmtryand

I lod&lt;fomwardtoworkingwithyminthe CINPprogram.
My

best regards.
Sincerely yours ,
PM

PM,

MOD.

Profwa of Psychiatry

�</text>
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                    <text>w...“

March 2“, 1969

Dr. Allen Raskin
National Institutes of Mental Health
514514

Wisconsin
(base, Marylmd

Chevy

Dear

Ir.

Raskin:

have recently completed our report of the trials
of cyclazocine as an antidepressant. I am writing to
aakifmytrialsbygmpe ctherﬁxmAbuzzambaMSchiele
have been reported, and if so, if the data is available.
We

Many

thanks.

Simly
Max

rink;

yams,
M.D.

Professor of Psychiatry

MF:kp

,

WWW-aw

w" m,wvva

Viv-w,-.

a?

�</text>
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                    <text>Hard) 2Q, 1969

'

Dr. T. A. Ban
Douglas Hospital
6875 LaSalle Blvd.
Verdun, Quebec
Canada

Dear Dr. Ban:

I

that you have canpleted a pmlimirm'y
in
the
of depression. You know
of
cyclazocine
survey
we am particulwly interested in this application, and I an
have recently heard

Want

writingtoask foracowofyom‘pmliminaxympwt,vmenthatmy
beoane available.
Many

thanks and

my

best-regards.
Sincerely yams ,

cu...

ma,“

_

,_.

Fwy—VF-

Max
WWWVv.Ww-.—W.

w:

m

Fink,

M.D.

Professw of Psychiatry
MF:kp

�</text>
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                    <text>TO:

Dr. C. Forster

FEB-i:

Dr.

DATE:

March

25, 1969

hi. Fin}:

have supported the appointment of psychiatric assistants
from research funds for more than a ye r and one~haif and I
am writing to ask that you undertake a report to the administration
we

'regarding the foiicuing:

experience in tenns of number of aides, assignments

1.

Our

2.

Training programs offered, and degree of participation,
limitations and handicaps, certification.

and attendance record.

‘

3. Medicni status and any unusuai exoerienccs (please
obtain this from the medicai staff}

patients, staff

4.

Acceptance or inch of acceptance by

5.

Consents regarding changes in sociai and community
behaVior of esch of the aises,

6.

Recommendations ‘egarding

7.

and/or administration.

ultimate funding for

continuation of programs’beyond 12/31/69.
Any

other

comments

that

may

suggest themseives.

beiieve these men have contributed to our programs but an
assessment is necessary. In view of the restrictions in funding
which I anticipate, I wonid like to pian that this program be' .,
c'f€:*
independent by January 1, 1970.,
I

.

J

_

HF:kp

cc:

Mr.

I.

B. Schwartz

�</text>
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a
V

”7...."

Dr. C. Forster

TO:

DATE:

March

25.

1969

‘

Dr.

FROM:

M.

Fink

have supported the appointment of psychiatric assistants
from research funds for more than a year and one-half and I
am writing to ask that you undertake a report to the administration
We

regarding the following:
1.
2.

,,
q.

.

Our

experience in terms of number of aides, assignments

and attendance record .

Training programs offered, and degree of participation,
limitations and handicaps. certification.

3. Medical status and any unusual ex eriences (please
obtain this from the medical staff

..m...,.,w,4.

"1w...

"my-hw—V—v-

patients, staff

4.

Acceptance or lack of acceptance by

5.

Comments regarding changes in social and community
behavior of each of the aides.

6.

Recommendations regarding ultimate funding for
continuation of programs beyond 12/31/69.

7.

Any

‘wrw‘ofw‘n—‘rv-

and/or administration.

.vww'rﬂ'muw

m
w

other

comments

MF:kp

"way-v-

‘-

(avw.w*

may

suggest themselves.

I believe these men have contributed to our programs but an
In view of the restrictions in funding
which I anticipate, I would like to plan that this program be
independent by January 1, 1970.

assessment is necessary.

wrwmwur-

riv

that

cc:

Mr.

I.

B. Schwartz

�</text>
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              <elementText elementTextId="37962">
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                    <text>r

wuww. 7:

snw~~wsn-

were,..

«w ..

w,w-

;. .

,

..,ar- 1 :1

wwwu-u-mm-.mauv-WIFVJWVJWT‘xw v.-.:..—w_uw ~wW-W

V

.

25,

»-

... \tw-vyzx'v-wu-rwav‘f«aqua.
~.

awmamvwvw- «-:.~r- w.

1969

Mr. Donald Cheetham

;

:

—x3Juv-

March

E

i

—.

-

Smith Kline a French Laboratories
1500 Spring Garden Street

Philadelphia

l.

Pennsylvania

Dear Don,

Recently I called regardin a search through the Thorazine
literature for mention of comp ications in relation to skin

taking the liberty of enclosing the original
I would appreciate a
similar search for the following terms.

disorders.

letter

I am

from Dr. Guthrie to Dr. Kline.

bullous dermatitis

eczematous dermatitis

E

vescicular dermatitis
dermatitis venenata

?

bullous erythema
bullous multiforme
weeping eruption
oozing eruption

'

g

g

*

photo—allergic dermatitis

%

pphoto-toxic dermatitis

i

with or without

t

vesciculation

eczematization
bullous reaction

E

as a consultant to the State of New York with
regard to a case of this kind and I would appreciate all the
help I can get in presenting a fair statement of the toxicity
I am

acting

ascribed to Thorazine.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

-

.

Wm-» .W.

., .. -7

. .-..

.

r. u 9.

�</text>
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                    <text>March 25, 1969

Spitzer
Psychiatric Institute
West l68th Street

Dr. Robert L.

The

722
New

York, New York

Dear Dr.

Spitzer:

terribly embarrassed that my accounting system
failed me, but during the past few days my secretary
reminded me that we had not obtained the enclosed checks
soon after you lectured here. Please accept these honorariums
I am

behalf of your participation in our programs and for
the assistance you have given Stanley Feldstein.
on

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

25,

1969

Dr. Burtrum Schiele
Department of Psychiatry
University of Minnesota
Minneapoiis, Minnesota
Dear Burt:
copy of our report as submitted to
and
Phanmacozogy
Thenapeuzicb.

Enclosed

Clinical

is

a

draft

Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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“an.“ 1...

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March 25 , 1969

Dr. Daniel X. Freeman
Professor and Chairman
Department of Psychiatry
University of Chicago School of Medicine
Chicago,

Illinois

Dear Dan,

It is

a pleasure to enclose reprints of our reports in the
edited by Dan Efren, recalling the splendid meeting
of two winters ago. The assignment gave me great pleasure and
has been rewarding in ideas for our continued research effort.
new volume

Recently I met your associate, Jack Green in our
mutual roles as Chairmen of the Computer Committees of our
respective facilities . His novel views of narcotic antagonists
were of special interest. The differences in emphasis between
our Department under Al Freedman and the existing facility

at Mount Sinai became grossly apparent. Dr. Green seems
to be involved in the selection process for a new chairman,
and is less acquainted with the research and comnunity action

programs fostered by Al than would be desirable. In your
discussions, a description of these programs, from your
vantage point, may be nutually useful.
My

best regards .
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

ME’:kp

enc

o

e

,

.

,

“v“.

v

.

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v,

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�</text>
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p.-

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.

u

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u

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2

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v

‘w‘d'r.“‘Vx' um.-- rmmms- rv-cv

March 25, l969
Mr. Arthur Werbner
Management Science Advisor

Honeywell, Inc.

Data Processing Division
West Druid Hills Drive North East
Atlanta, Georgia 30329

Electronic

6

Dear Mr. Werbner:
I regret that the reprint you requested is no longer
available. I am taking the liberty of sending you a copy of
another report which describes the application of these
studies and which may be of interest.

If your thesis is directly related to

EEG

analysis,

you to ask more specific questions
it
in relation to the problem and perhaps we can be of some
additional help.
may be useful

for

Sincerely yours.

Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>l

v.

,
A

,V...,.

March

‘&lt;._V_V-.,,..&lt;.=.t._-v_....-,

To.

,..,,A

,ﬂm".

"Hy—.‘..,c.m

.

25.

1969

Dr. Joseph 6. Bird

Director. Experimental Medicine

Sterling-Winthrop Research Institute
Division of Medical Research
90 Park Avenue (5th floor)
ﬂew

York.

New

York lOOlG

Joe.

Dear

copy of our report as submitted to
and
czinicaz Phaamacozogy
Theaapeutica.

Enclosed is a

draft

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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                    <text>March 25, 1969
Mr. Jack M. Rosentha]
Room 13

Sun and Shore Hotel
North Bath Avenue
Long Branch, New Jersey

Dear Mr. Rosentha]:
I regret that we have
studies have just begun.
Thank you

no publications since our

for your inquiry.
Sincerely yours,
Fink, m.
Professor of Psychiatry
Max

MF:kp

�</text>
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a-

»

~

~

-

wan»

~

wvw~.v«-.va- .w

March

.-

nwn—wmu

.

-.

~

25, 1969

Dr. Walter Modell. Editor
Pharmacology and Therapeutics
Cornell University Medical College
1300 York Avenue
New York, New York 10021

Clinical

Dear Dr. Modell:
I am pleased to enclose a draft copy of the report
“Clinical Antidepressant Activity of Cyclazocine - A
Narcotic Antagonist" for your consideration for publication
in Clinical Phaamacology and Thenapeuzica. This report
summarizes our experiences with cyclazocine in the treatment
of depresSive illness an application which was suggested
by our studies of its characteristic EEG effects.
—

studies were completed last year but I have
withheld publication pending studies of this compound by
other investigators. Reports of studies by others will
These

be presented at the meetings of the American Society of
Clinical Pharmacology and Chemotherapy.
Thank you

for your consideration.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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