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                    <text>July 7, l969
Dear Prof. Kielhoiz,

letter

of June l8 regarding the l960
to working with you and should
the
like
share
to
origins of this program title. At the
first
Rome meeting of the Program Committee, the subject of amphet—
amine abuse was suggested by one of the European colleagues
and l suggested cannabis abuse—- the two recommendations reflect—
ing the relative importance of the problems in our respective
countries. When the subject of amphetamine and barbiturate
abuse received more votes of the Committee than cannabis, l

Thank you
ClNP symposium.

for your
i

look forward

accepted the decisoon, until one member remarked that a matting
had just been held in ltaiy on the subject of amphetamines. l
had not been to the meeting, nor had anyone at the Program
Committee, but in Liege, l heard the details from Munkvad and
from Jacobson. As it seemed redundant to schedule another
meeting so soon on the same topic, with the same participants
(probably), l urged Dr. Vinar to assign a broader topic to the
section. This title will permit us to provide as broad a
program as we wish.
i look forward to welcoming you in New York in December,
and surely the final plans can wait until then. in the
meanwhile, i would suggest that you write to Gharattlnl to
obtain a copy of his attendees and the titles of their papers.
We may provide an opportunity for one to summarize the
experience with amphetamines over the world, the pharmacolgy
as is now known, and the Japanese and Swedish solutions to the

problem of abuse.

recommendation is still that a more timely and
interesting meeting could be provided about the subject of
cannabis. Many studies are now in progress in the U.S.,
ltaly, Greece, lsrael, West Germany-- there is no shortage
of good, young workers. The material is new, and at a
minimum it should be possible to have 2 halt—day sessions
or even 3. The latest meeting on cannabis was held earlier this
year in London and focussed on the chemistry of the der—
ivatives. i know of no other meeting planned.
My

own

The only question is the relevance of the subject for
European investigators. if they are not now interested, they
will soon be; for with the American talent for marketing,
the European nations will have a cannabis problem very soon-~

if it isn't already there.

if this is not satisfactory, it should be possible to
arrange 3 reports-~ one on amphetamines, one on progress in
barbiturate or opiate therapy, and one on marijuana. Such
a program would be educational and acceptable, but less
novel and less innovative than one focussed on cannabis.
Such a mixture is not publishable, but a symposium on
cannabis may be.
i

in

New

look forward
York.

to

working with you; and

to

welcome you

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                    <text>-

m“.-n

.

July 7, l969
Dear Mrs. Spaeri,
Thank you very much for fhe bibliographies which you
sen?
recenfly
me; i did find ihem most helpful, and wish +0 congraiuiafe
you on a Job well done.
The bi-weekly cifaiion lisf would be mosf useful, and i
would be grafefui if *hese could be seni lo my iaborafory, for my
use and fhaf of my assoclafes 7
Many

fhanks.
Sincerely yours,

Max

Fink,

M.D.

Profassor of Psychiafry

mf/

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                    <text>July 7. l969
Dr. Otto Schwarzkopf
Schwarzkopf Microanalytical Laboratory

56-19 37th Ivenue

Woodside,

New

York ll377

Dear Dr. Schwarzkopf:

Enclosed is a package presumably containing heroin.

it
heroin

possible for you to estimate the amount of
available? It is important for us to determine the
amount that our subjects are taking from the street. The
degree of accuracy for this determination is not high.
We would be satisfied to know the amount to the closest

Would

be

milligram.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
ENC.

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                    <text>July 7. l969
Dr. James Inglis
Department of Psychology
Queen's University
Kingston, Ontario

Canada

Dear Dr. Inglis:

associates add I thank you for the opportunity to read
your pro-print. “Similarities in the Side~£ffects of ECT and
Hy

Temporal Lobectomy in Man.“
Your review of

EEG

studies. indicating

an asymmetric

EEG

response to unilateral seizures, with accentuation of slow waves
the side of the application of electrodes is confirmed in
our studies as well.

on

of your argument is good. and we can find little
to criticize. Following your suggestion. we have recently attempted
to induce seizures by frontal electrode application. and must report
failures so far - the currents available are insufficient to induce
a GM seizure. But we will perservere.
The remainder

Again. our thanks

for your report.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp

P.S.

The

report lacked the figures. and although clear without
we would be pleased to have these to supplement our

them,

reading.

�v'

;_.

awav-w u.»

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7.“

*wan- r,_ ma
,

-

.

‘
4n“ V »~m.H.Vw—F.W'If":‘I—I'ﬁyva’W'V‘V‘mleﬁhwdgm‘
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aw-.5“ . -7.r-V,V-(W,_,
«

,ww-n ~~\.Ww'_l'.ﬂ/--, wwamr‘i'wy-rﬁ,Wgrf»; wavy- vw

July 7,

1969

Dent 3111,
The

listing

from

thin laboratory nhould ha

changed

to:

wwﬂln'v'mld‘

.v—

.m-u—r

'W‘ar'r‘

w

Pink, M13, M.D.
Professor of Paychtncry

Haw York

Medical College

5 East 102 Street
New York City 10029

the tlephonc is correct.
Much

his address

it

of our data will
the same.

come

to you from Dr. Simeon. and

Sinceroly yours.

Max

Pink, M.D.

�</text>
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                    <text>w vaw—q—w"w”...“umm-

”Rama-{r

r;“v«»'&gt;3.-VVW.-«(Vum

a

~~

W-I ---..~ v

r"

ummr‘arunnnwnw- r"
,

-

-

»

mo

~

wwmcv

July 3,

-

«.—

\.

'

...A.

.

“am

1969

Dear Dr. Vinar,

Io anowor to the questions of your
1.2: as in

letter of

nood a second co~chairman

Juno 22.

for panel k.

I

do

letter of

June 30:

not think

we

roally

3: A committee wasting probably shoulé be bold, but the
make this lens possible. I do not nee that we are too
would
oxponoen
short in tin. and perhaps much of tho work could be done by mail, as
you are now doing it. The decision should rent until winter, when you

can appraise the products of our work.

a: agroo.
5: The names suggosted, Popper or Asimov ato
Anothot that has been suggested is C.F. SBOW.
A

copy of the latter I sent to Dr. Kiolholz
(and commant).

for your information

satisfactory.
is enclosed

Sincerely yours,

Profeanor of Psychiatry

�</text>
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                    <text>wt

——.—w»-‘Hw-v‘w

&lt;

a

w,

_

.w—F

‘41'n’v‘w“

-

w- —-.

.vv v-mmr: w-v

-

~

m?“ "mwlm

mum‘umw-wwwr—www-a—'wmmu-er-

--.

.

July 8. 1969
Dear Dr. Munch,

;
g

i

A

a.

mam-1.1

V'W-

'H—nnrm"

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:

;

3

;

"x.

mun-n

=1-

I very much appreciate the reports which you kindly sent me
I have read with great interest. The material is of special
interest, for if it presents the most salient date upon which criticism
of cannabis use is based, then the criticism is indeed poorly founded.
The two reports containing the most detailed cases, that of Milean and of
and which

Greenest, are the most convincing. Dr. Milecn's data is the most
damaging, and cannot be easily faulted. Dr. Groseman's in week for the
teeaon that a special type of American becomes an oxpetristed 'hippie‘
and then the use of anything aunt be assumed and the results can be
ascribed to anything.

hetero you conclude that our laboratory is a defender of
cannabis use, please be assured that we are not. We have reviewed the
available literature and concluded that there was insufficient evidence
upon which to base any conclusion. and have pretence new extensive
experieental and sociological studies, including some overseas in arena
where potent cannabis in is use.
with the authors who rail against cannabis use
without date is that they play into the hands of the community leaders
who wish to use such a movement £0: political purposes, and serve not
to decrease the use of the dings, but to increase the distance between
potential users and the rules of the establishment. we recall with
great interest the sharp reduction in LsD use when acme of the fearful
consequences were advertised. Not the general consequences of psychosis,
but the specifics of genetic damage. Until such a connection can be
found, if it indeed exists, the present ceiling against cannabis by
articles purporting to demonstrate connection: will serve no useful
purpose. In this I would include the articles by Glett, Leonard. Munch and
Luby, 0‘ those that you sent me.
Our argument

I, too, will he at the

and would be pleased

Again,

my

to

meet you

meeting, at the addiction
after theeseeaion.

AHA

thanks for your kindness in sending

me

ww-

the reports.

Sincerely yours,

www"ﬂ'm‘l«~:&gt;v

Mex

Fink, M.D.

symposium,

�</text>
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                    <text>....

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..

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w—rq—VlwImr-mrwv1&gt;v—HI"a—Iv‘

-..n.—.., V.”my......,.-.,»n.w~,~r\",v,-

rv—

v-m» '.'~«‘rt

July 9. 1969
”to

Alerd

Now

York Modical Collogo

Ho

ROOM,

H.13-

Profoaaor and Chair-an
nopartoant of Payohiatry
5 Eaat

Now

lOan Stroot

York.

Now

York 10029

Door Al.

It givoa no groat ploaauro to trananit tho oncloood roport
of atudioo cooplotod by our third yoar roaidonta during thoir
oloctivo in Biological Paychiatry. 1968-1969. Dru. Richard
Abrooa, Rohort Lavina and Michoal Taylor hora boon unusually
productivo.
Tho ropOrto rotloct divoroo intoroota. Bra. Taylor and
lovino have collaboratod in atndioa of oar rotio and ochiaophronio.
Ihoir firot roport. "Tho Intoractivo Effooto of Matornal Schiaophronia
and Oliaprins Sax" haa boon publiahod in Science (164: 723-726,
1969), and a aocond. "Pnorporal Schiaophrooia - A Phyaiological
Intoraction borvoan Hothor and rotua" in in proao in Biological

.,

M,

-o

v

A

v

H

R‘:l'-A‘1ﬁ-ﬂf4"ﬁ&lt;(.-"‘

.—

wj-qw

-mrrucwurv

Po chiot . You know that thia work rocoivod ouarda both locally
Nov York lonrological Socioty) and nationally (A.B. lonnott
Clinical scionoo Award of tho Bocioty for Biological Paychiatry).
Tho atudioo hora boon follouod by an additional report on "Tho

Influonoo of tho 8a: of Hoopitoliaod Schiaophronica on Thorapoutic
of Ronroloptica" which haa boon oubnittod to tho
Bullish Jaunnal 0‘ Rsychiattg. Ho hora ainco proparod otudy
protocola to contirn and oxtond thoao chaorvotiona by oooaya
in tho thorapy of achiaophronio.uith penicilloaina and with

Dooogo Loyola

atoroida.

Dr. Abra-a haa collaboratad with anobora of tho ataft in
atudioa of nnilataral convulsivo thorayy, confirming tho difforoncoa
in nooory function and aioilarity in clinical roaponoo to bilatorol
convuloivo thorapy. A opocial loatnra of thia work haa boon tho
dotinition of oaynaatric BEG pottorna which aro rolatod to tho

difforant hohowioral roopanaoa.

'h’u‘h.

�-2-

Dr. Freedaan

July 16, 1969

earlier studies of the California I scale as a
of
therapy choice in mental illnesses , Dr. Levine
predictor
examined the role of socio—psychologic factors in the diagnostic
and therapy practices in our psychiatric service (Effect of
Social Attitude on the Ireatnsnt of Psychiatric Patients).
Based on

also replicated a study of the effects of Cogentin
on both EEG and behavior of psychiatric patients receiving
convulsive therapy, observing that this anticholinergic drug
He

slow wave activity following EC! and elicited
m
the pre-treataent behavioral syndrome, suggesting that cholinergic

reduced the

activity increases during the inter-ictal period of
reported is to be completed.)

301‘.

(This

viable experimental view of the precipitation of anxiety
is encoapassed in the lactate studies of Pitts and Molnre
(New Eng. J. Med” 2778 1329-1336. 1967). Dr. Taylor replicated
their study, verifying that infusions of lactate precipitated
sysptone in anxiety neurotic patients and not in nomls; and that
these precipitated synptoes can be blocked by intravenous calcium
The study was extended to demonstrate EEG changes with lactate
and to pioneer the use of this nodal to define the activity of
new psychoactive anti-anxiety drugs (the Precipitation of Anxiety
Symptom by Lactate Infusions).
A

-

FFH'a-

.
A

g
"qr

-.-—,

"vat-WWW“wammwmrmm-awxm;m-a

These are only a few of the studies that have been done.
Dr. Taylor with Dre. Spero and Sisson also coupletsd a review
of the clinical effects of chlordiasepoaids in our clinic,
suggesting that adaptation (tolerance) does develop with this

drug.

“I“

(CUMe "imp. Rue, ,139‘1‘,
“.3
mush“
Abrams also completed "A Manual of Convnlsive Therapy"

ha.

1969). Dr.
which described the
and

varieties of techniques for inducing seisnres
is being distributed to residency training programs in

various psychiatric centers.

year has been productive. challenging and stimulating
and ny associates join no in expressing our appreciation for
this opportunity to participate in the training program.
The

Sincerely yours .
a,"

._,,,‘

‘
_,.~

4.,

.lwmwfwaﬂﬂm'rr

Fink, um.
Professor of Psychiatry

Mar
M! :kp

-

�</text>
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                    <text>4

J!

I‘m

(2

Dr. Harold Aaron

The Hedical

New

y ’y
r560 Q'
‘6,

.

only 11, 1969

Letter

York City

Dear Dr. Aaron,

interest.
clear.

I have read the summary, Methoqualone and REM, with
report seems direct and well written, and is very

The

As I am not in the habit
am unable to contribute

of regularly recording aleevaEG
records, I
to the content of the report, nor
to assess its fairness or accuracy.
for your interest, and for your offer of a trial
May I suggest that the address of record
is not the New York University College of Medicine, but the New York
Medical College:
Thank you

subscription to medical Letter.
Max

Fink, M.D.

Professor of Psychiatry

York Medical College
East 102 Street

New

5

New

York City 10029

Sincerely yours,
Max

mf/

Fink, M.D.

�</text>
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                    <text>July 14.

1969

Dr. Michael Taylor‘
9309 Murillo Avenue

Oakland, California 94605

Dear Mickie,

Enclosed are letters, draft copies of various papers and two
papers that need your attention.

Influence of the Sex of Hospitalized Schizophrenics on
Therapeutic Dosage Levels of Neuroleptics" has been corrected by
me. A xerox is enclosed for your changes. The original is on my
desk and the figure is now being made.
"The

The

enclosed.

hypothesis paper has been corrected add a xerox cepy is

Please correct both and send them back to me. I presume you
want to send the hypothesis paper to Lancet and the "Influence of
Sex ..." to the Balxish Joannal 05 Psychiatay. If you will send
along a covering letter for each we will get them out.
The

letters

your attention.

from Drs. Bouthilet and Nortis gt_gl;_ require

The letter from Dr. Gottlieb has been answered and I have taken
the liberty of sending him a copy of the hypothesis paper. Dick
Abrams has written a protocol on penicillamine and this will be
processed in the next few weeks. Dr. Volavka has found more to do
with the lactate and that will take some time. The notes on the
hormonal treatment of schizophrenia are interesting and I have asked‘
Dick to write a protocol. I hope that we can do the penicillamine
at Manhattan State and the hormonal treatment in Montrose.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enclosures

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                    <text>W.

&lt;-

'm'mnw—Iwnnwv-7r"--

.amn‘

"ﬁre-"v .- .7

“wen-my“, w .W. my. r-w.'7,—

July 14. 1969
Mr. Denison Rey

Squadron end Piesent
292 Madison Avenue
New York. New York 10017

Dear Mr. Rey:

It was kind of you to bring my attention to the case of the
U.S. vs. Finley. Unfortunately. I do not consider myself an
experifin marijuana having Just begun our studies less than one
ago. I do not have any information which has not been pubiished
gear
and could do no more then present data which is not
others
y
from

this laboratory.

Sincereiy yours.
Fink, ".0.
Professor of Psychiatry

Max

Nthp

.1

�</text>
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                    <text>July 15. 1969

lg”
41s

Hm

Joni-nod

am.
WornHow
York

Great

m.

bur Rune.

. no have had difficulty
n
After my verbal
iotioo.
inst:

ks we have repeatedly

-

with our moo since its
complaints. we took tho. extraordinary procedure of oi'i'iciauy
writing to you.
This «mod to produce results so that for the put those
few breakdown and reasonably notiofoctory
Mimi:co.u: have but

u

m1: is to indicate to you that this =mhioory has not

boon functioning since July 1. that each and every one of
12 disks have boon scrub!“ so that
will inquire at tout
fu‘l'i
those
two
programs.
day: to restructure
om to

it

fowsuo no the disk drim and I would
om
mount your imdiou attention. I would trust that you will
The problem

give as credit for we route! costs siooo July 1. since that
on tho undontooding with which we continued our niotiooship.
Sinceroiy yours.
Fink. «.0.
m
Professor of Psychiatry
H152”)

cc: Mr. T. Blower
Mr. T.

J.

Notion

�</text>
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              <elementText elementTextId="39773">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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  <item itemId="3976" public="1" featured="0">
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                  <elementText elementTextId="103029">
                    <text>July 19,

1969

Dear 81d.
Thank you

for the invitation to participate in the

ad hoc study group of tho ICE?-~ an invitation which I
gladly
The subject handings art timely, and the coneopta need ravicw. accept.
The

title

"Interface between Technology and

Han”

is probably

as good an I can devido. if it warm neceasary to change. I believe
the focus abould ho on the problems of applying the technical achievn«
manta of scieaco to our disciplinos; of the need for rodundancy in
research approaches; and of tho mood for better communication of
projects and resultu,-to avoid duplication..Tho problems of presentation
and publication may alno bu covered, although this more properly
should be a separate topic.
My acceptanee is auhjoct to one problcow» Fritz Froyhnn has
planned a study group on teaching psychopharmacology. I hove urged
him to do this and would like very much to participato in that
projoct
ciao: it is a principal issue at out College now. In planning the
sessions, porhapa you can bring this to Wittcnborn's attention.
My

best regards.
sincorely yours.

'Mnx Fink, M.D.

Profeanor of Paychiatry

mf/

�</text>
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              <elementText elementTextId="39758">
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              <elementText elementTextId="39762">
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              <elementText elementTextId="39763">
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  </item>
  <item itemId="3975" public="1" featured="0">
    <fileContainer>
      <file fileId="5163">
        <src>http://exhibits.library.stonybrook.edu/mfp/files/original/364139700f4f55322c189398a7860898.pdf</src>
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                  <elementText elementTextId="105770">
                    <text>July 20,

1969

Dear John,

.

It was good to recoiva your chatty latter. I had just
upent many pleasant hours with Elliott. diocuosing his programs
(at the A.M.A. and A.T.3. mootingo) and your letter rounded out
what I had hoard. The only note that teemod omittodffron your latter
that be highlighted was a possible study of ualoxono. If thorn will
be a better way of creating opiate addicts, it should coma from a compound with the specificity of naloxone. WE ate now at 3.06ms/day and
one of the contrnccﬂ that I discussed with Sid Cohen_uns on: for
embedding naloxone in silaotic.

WNW

,,._mm_,_.y_...._‘

‘.

Your visit during September will be most welcome. The week
you aoluctod, unfortunately in tho timo of the International EEG
aeotings in San Diego. Indeed, I had hdped to visit you during that
week. If you will be in How Yark, you should visit our unit. It has
some features quite different from Dole and Hyswandor. The beat
data can be gleaned from Dick Ronniok and Arthur 23kt, and I will
arrange to havo you spend some time with thou, if you wish. You should
also visit tho unit at Gracie Equare ﬁospital, to sea what a mothadone
program can do when it is out on a mooey~making baoin.

if

you will spooify tho time you will be to New York,
you to talk to our researoh seminar group on
your experiences. lhoso seminars ore infernal, attended by 10~12
members of the staff and some residents, and provide us with the
opportunity to discuss issues of interest to us. If you are agreeable,

I

woold

Also,

like to ask

I will ask stun Feldatein
in my absenoe.

(who monitors

the norios) to not as host

nave a good summer.

Sincerely yours,

Max

mf/

Fink,

M-Du

‘

�</text>
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                    <text>July 20,

1969

vv-vv-vb-m"

wannmv.

Clearinghouse

Springfield,

Va.

c'
u:
1.4

.r-n

Gentlemen:

Kindly send us coping of the following reports:

"’5

"W?

”"9”?“

v‘r'xw‘v'ww

wrv'wml'm'

A

and ask

costs.

we

that

et

AD~683 734

Dubes,

AD~686 216

Borkhout

a1
&amp;

Walter

M?

0.65

M?

0.65

would also like to subscribe to Clearinghouse announcements
you sand on a list of the categorioa ana their respective

Thank you.

Sincerely yours,

Max

Fink,

M.D.

Profeooor of Psychiatry

5 East 102 Street
ﬂew York City 10029

�</text>
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              <elementText elementTextId="39743">
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                    <text>,)
.

k.

""F'rnwwﬂ'fdivv‘ﬂ3w_-vx-&gt;;-‘\

‘k-¢_«

1.".

.w

July 20,

mum-quay,“

1969

Dr. William Banana

v-vnran—x-wnmm-r

Presbyterian Hospital
New York City

.nuwmtvwl:wr,so'l

Dear Dr. Banana.
um,“

“gr

“—7..

”NW.

Thank you for your invitation to aprtictpate in the
nearing of the New York State Radical Sociory. Fob. 8-11. The
subject of computaro in medicine in of inturcur to no. and I would
1970

be planned to

participate.

A: you well know, the current arc of computers in
psychiatry is limited to a few research applicrclonc, but the programs
now in trial use are quite interesting, so that the ropic of the next
5 years can be adequately counted.
1

look forward to

participating.

enra-

sun;

Sincerely yours,

,
-«

:mmxgrmvu

a."

,

wwmv-ww

Max
;-._uq,,-

r;

‘w—wﬂlﬂrwv

,rr:.~11

.muw

m

r
..._

Yink, M.D.

Professor of Psychiatry

1—?

mf/

�</text>
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              <elementText elementTextId="39732">
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              <elementText elementTextId="39733">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>.w,

A

‘

My,“

W's—r"

~

"wmrmrr,

('Jarmmnm

“wry

om",

July 21,

.wrr

1969

on,

Dr. Jane: Fujimoto
-Morquotto School of Modloioc
xibwaokoo
Dear Dr. Fujimoto,
Thank you for the opportunity to read your report
of the motobolito of onloxona. It in also: and I do not think
that any additional data be included in tho report. except the
following:~

"Fir! sullen: of pooled urine

from patients wore root to
by Era. Max Fink and Arthur Zaka of the New York Hodicnl
College. The patiootu wore participants in a study of noloxone in the
treatment of opiate doponoonoo and «are roooiviog botwboo 150 and 1.8
grams onloxono daily in sloglo oral doses. The dosogos oood wore
highor than those proviously reported (3) goo were administered to
dotortioo 1f higher doaogoo would extooo the duration of offectivo

this laboratory

antagonism to heroin.“

This paragraph could be used instood of the
sontonoeo on page 2.

I

first

two

also appreciate

an aoknowledgemont to my oo~worker,
if
nooossory to acknowledge our
cooperation any further than alrnady done on page 2 (1.0., . . . with
Dru. Max F1nk and Arthur 23kt of the . . .).
would

Dr. Arthur H. asks,

It is

clearly your

you fool

it

but the work is
as may be conventional,

kind to suggest co~aothorohipo

own, and such acknowledgomnt

in already includoa on page 2.
Good luck

!

Sincerely yours,
Max

mf/

Fink, M.D.

Protonsor of Psychiatry

�</text>
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                    <text>menu—rm.“W_—,‘-m ,,...r,,...,.w“:

WWW
,

_

r
.W'mrvur

_
4_ m4—

-~_—‘—y:r...\wi

w,

n

y

F

'- w H“...w“7....\ we‘d..."
.

‘_

,

“in".

.

‘A‘Ae

4.‘1

July 22, 1969
Mr.

Phillip

New

York.

A!

Pagano

Control Data Corporation
575 Lexington
New

York

J._

,

Dear Mr. Pagano:

in your telephone conversation with my secretary,
1969
copy of your invoice #12680, dated July 9,
31
1969
July 1969".
through
which states "rental for period 15 June
On June 12 we received your invoice #A78250 which was to cover
rental for the month of June.
there has been an overcharge for the
It would 15appear that
- 30. He would appreciate it if you could check
period June
your records and clarify this matter for us.
As requested
I am enclosing a

Please note the proper purchase order
on all invoices.

#114371 should be used

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mszp

madam-V‘JM

�</text>
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                    <text>July 22, 1969
Dr. Edgar Gruuwaldt

Geigy Pharmaceuticals
Ardsley, New York
Dear Ed,

I reported earlier,

have had one adverse drug
experience in the kecimiprnmine~1mipramino study. The
potion: developed a severe agranulocytosis aftor inipraaino.
Ho responded to treatmant, and was discharged "recovered"
for this opisodo. A contributing factor may have been the
presence of a nooplawm of the nnsophnrynx - for which ho
had bean previously trantod, and is now boing treated.
As

um

Sincarely yours.
Pink, H.D.
Professor of Psychiatry

Max

Krakp

.nc I

�</text>
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Jhly

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4- V.

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w:”w rA&lt;nVY7WI~vl—-wrnvw"wr—W

28 . 1969

Wewinbeplmodtohawywmmwwkmm

dmyusocistosmﬁnnnd. Ilodcfmu'dmmingywin

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Professor of Psychiatry
MPdcp

v'rlrv

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                    <text>July
Er.

mama

A.

2‘4, 1969

Taxwa

9309 Murillo Avemxe

Oaklmd, California 9%05
Dear Mickey,

Emloeed are

final eop’ea of yam letters

and the two

reportsmidamsentwtﬁmisweek. 'Iherepmintsfran
Science have not yet m-m'yed althmgl we keep getting 81

Ewing We}? requests.
Enclosed

isaahoxtmtethatwillappearinWanm'sDa;

mmmportsambeing Wedbylmﬂinme 3 its
pmlicaticne.
Now

can

I take a vacatim?????????????

Bob twine called to give us his address and to get some
data from Stanley. He eeems to still be depressed but I hope
is trmeient. Didc received a gift of four tickets to
it
Brussels and return and hopefully will use the return next week.
My

best regards.

_A.

Sincerely yours ,

warm“

Fink, MD.
Professor of Psychiatry

Max

MF:kp

(Your

bill is now

$377.92 kp)

�</text>
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                    <text>July

25 , 1969

Acting Secretary, Board of Medical Ebcminers
The University of the State of New York
The State Education Department
800 North Pearl Street
Albany, New York 1220a

Dear 1r. Wright:

writing on behalf of Dr. J iri Roubicek who is applying
to the Board of Medical miners for medical lioensure by

I

am

mdorsement.

I first became acquainted with Dr. Roubioek's work 1:11er
the literature, for he has been a major contributor in the fields
of clinical psydxiatry, psychophammology and electroencephalography
for more than twanty years.
of the Gmimen of this Department
at the suggestion
M.
Freednm, I visited Dr. Roubicek's
of Psychiatry, 11". Alfred
laboratory in Prague. I was impressed that the work that he and
his associates were doing was excellent and was pleased, on my
It
return, to support a recoumendatim as visitirg professor.
two
In 1968,

was our expectation

that he would join us for

begixming in October 1968.

one

or

years

joined us in November 1968 and since then he has been
closely associated with the programs of the Division of Biological
Psychiatry. I have found him to be an experienced scientist and
He

a reliable, co—oPerative and charming co—worker.
Because of the events in Czechoslovakia, Dr. Rmbicek is
seeking to remain in the U.S. I believe that he is a capable
md well trained psychiatrist and would support his request
for lioensure by endorsement.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>'

July

25 , 1969

W. Gilbert Goller
Bwefit Plan Counselor
Teachers Insurance and Amuity
Association of America
730 'Ihird Avmue

New

York,

New

York 10017

Dear Mr. Geller:
Enclosed are

mnbem of the

five applications for enmity emu-acts from

Intermtimal Association for

Paydmia‘lmic Researdx;

a murmur sheet of the gumterly pmnimn salary reductions and
contzﬂmtlon payments; md a check in the mount
insgi‘mtional
355.'+6.
of

It is

our intentim to submit quarterly payments for the

participants from this association.

If you will send us a form for pranitm remittance
use than in the future.
Sincerely yams ,
Fink, NJ).
Bcecutive Director
Max

HF:kp

we

will

�</text>
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                    <text>June 27, 1969
Miss Anne walker
15

Littel

Road

Brookline, Massachusetts 02146
Dear Miss Walker:
Enclosed are some notes I wrote in response to your request,

and a few

reprints

which

reflect the actual data of interest to

me. There is, of course, much more data, as in animal studies
where electrodes and drugs are introduced into specific brain

areas for specific relationships to behavior, in human studies
with electrical techniques slich are not used in my laboratory
(as evoked potentials and contingent negative variation); and
with drugs not usually defined as psychotropic (anticonvulsants,
hormones, vitamins, etc.).

If these are useful or interesting, I would be pleased to
have you visit the laboratory for a review of the methods; and
to answer questions which must arise from such discursive notes.
The subject of brain function, drugs and electrical activity
is an important one, and its story needs telling. I an terribly
sorry that I am so poorly equipped, but perhaps your experience
and talent can salvage this tale.
Good

luck!
Sincerely yours ,

Fink, 14.0.
Professor of Psychiatry

Mex

Mmzkp

�</text>
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                    <text>July 28,
~

av
.,

paw."

:v.

11". V. G.

1969

ngo

Institute Superim di Sanita
Ram, Italy

mﬁ-r‘w-V‘

'

,

rs

wrm

yuaa'

Dear Duo,

will be pleased to have you pmaent your work to some
ofmyassociatesmﬁueZmd. Ilod&lt;forwardtoseeingywin
We

California

and

then in

New

York.

Sincerely yours ,
Fink, PM).
Professor of Psychiatry

Max

MFﬂcp

�</text>
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                    <text>July 28,

1969

Dr. Wilfred Dorfnan

Academy

of Psychasoaatic Mndicinu

Erooklyn 26,

Des:

New

York

Bill,

While I am not sure that our funds will allow the trip, I
would 11k. to plan to participate and suggest the following title for

a presentation:

Classification of FaychotrOpic

Criteria

This

titlc will

parmit

me

to describe our

applications which interest
active compounds in phase I

me nuw.

trials.

Thank you, again.

”4;

Drugs By Human

EEG

"ark of

such as the

many

EEG

years and the

identification of

new

for the invitation.

-

Xy

vw

best regards.
Sinceruly yours.

--.ow«m-—,—,;—.m~u

..-‘,_.-

Max

Wm“

Fink, M.D.

Prolelaor of Psychiatry

7w

.-.-.-nzv._-.w

mf/

�</text>
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                    <text>July 28,

1969

m. 0. Vinar

Senior Staff Scientist

'Ihe George Washington Bio-metric Laboratory
11'45 Nimteenth Street, NM. , Room 618
Washington, D.C. 20036

DearDo. VinarG

It was

a pleasure to have

you

visit our laboratories

I sorry that you had this diffimlty with
cancelled flights and I very much rage-t that my time was
so preoompied as to limit the oppcmtmity to discuss my

on July 23.

am

Prom-

behalf of the Intematimal Association for Peydwiatric
Research, I am pleased to. send you a check to defray the
expenses of your visit.
On

Sincerely

yam ,

Fink, PM).
Bxewtive Director
Max

MF:kp

�</text>
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W

July 28,

1969

Ir. Joseph 6. Bird
Director of
Maine
Resend: Institute

mung-um
90 Park Aveme

New

York,

New

York 10016

Dear Joe,
1M1): you for the two articles on
Win synﬂnsis inhibitors.
IhadﬂmeonebyW.Waybutrmthoadmr.

I,too,domtmthem1evmfwammmmkgm
Wtakmﬂnlibwtyofsmﬁmgitmtonmmn.

am, also, for sanding the cyolazoc-ine so may.
Shmly yams,

Max Pixﬂc,

Md).

meessw of

Psydxiattry

�</text>
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                    <text>July 28,
Hr. P. Bergnsns

Elsevier Publishing

1969

Co.

Amsterdam, Ratherisnds
Dear Mr. Bergmans,

I regret bothering you with a small problce, regsrding
twice in
subscriptions to the EEG Journal, but I have written
I;
would
the past few months and have not received an answer. I
of my oubscriptiong, to the
appreciete clarification of the state
Journal.

Through the New York Medical College, I have renewed one
nobocriotioo which is addressed to my home at
39

Arleigh

Great ﬂeck,

Road
New

I have also recently ordered

addressed to

my

lsborstory:
9r.

York

11021

1 second

subscription,

Hex Fink

Depertnent of Psychiatry,

5 Esst 102 Street
Rev York City, ﬁ.Y. 10029

New

York Medical Col.

subscription to my home is up to date, for I have
received vol. 27 #1 (July) last week.
The

subscription to
the January issue (vol.
The

office, which use to have started
26) has never been instituted.

my

vith

If the
apprecistc your checking your files.
incomplete,
records
the
or
for,
paid
second subscription was not
make
adjustments.
the
and
necessary
I will
plessc advise me
I

would

have requested our purchasing department
EEG Journal
to send you so order for a connicte file of the
arrive

Incidentally,

we

vol. 1 for Iy laboratory;
early in August.
from

Thank you

and

this order will

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July

29 , 1969

Mr. Dmid Kline

Endo Foundation
1000 Stewart Aveme
Garden City, New York 11530

Dear Mr. Kline:

It was kind of you to respond to our request 30 monthly.
are armious to bring othw scientists to New York to lecture
to our students , and this fund will be most useful in omtinuing

We

this

program.

Thank you.

Sincerely yours ,
Fink, H.123.
Professor of Psychiatry

Max

MP:kp

cc: Dr.

R. Jacobson

�</text>
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                    <text>July 29,
Ciba

I61

1989

romantic:

Portland Place

Landau V1.1, England

,Gmtlemm:

arresting
Buliwthisymﬂnﬂbafanﬂatim sponsoredhave
been

on cannabis, max-13m md

«th11101.

I

mixing
ﬁnbiologionlaspectacfﬂmommds. Itwouldbemost
imitedtoorgmize asimilarmeting inthems!

Mpﬁniflowldobtdnaoowofﬁnkwitodpwtidpmm

inyamswpmimumnas ﬂutitlesofmirpmsmtatim.

Wyn: fwmcoopex‘atim.

Sincerely yams,
Pink, NJ).
Professor of Psyddmy

Max

Mf'mp

�</text>
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                    <text>Dr.

W

July 30,
M.

1969

Itil

Missmzi Institute of Psydxiatry
5M0!)

Arsmal Street

Dear

Tum,

St. Lads, Hissmﬁi

63139

kind of you to invite me to visit 31:. Innis,
to the residents.
partiwlarly to present some of our workmmmal
of convulsive
I have recently canpleted the meloaed
send enmgh
am
can
I
of
surewe
is
interest,
marapy. If it
residents.
for
copies
yam

It was

Is
Hy

Wt

10—11

a

good time

for you?

best regards.
Sincerely yams ,
Fink, M.D.
Professor of Psydﬁatry

Max

Ml’:kp

�</text>
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                    <text>July 30,
Dr.

Maia J.

Editor

Braoclmd,

1700 Eighteenth

Washingtm, 0.0.

St. ,

1969

PM).

NW

20009

Wham:
Fwammberofyemlhavebemlaatuﬁngmcmvulsive
Mymdwtmlhadtheoooaaicntomakesuchapmsmtatim

State Hospital, Jamﬁm Cole mated that a manual
ofECI‘mightbauseful. Wiﬁxﬁlismammgmntwehmmpamd
ashort 8mm: "Oamlsive Ttmapy - Methods mdApplicatiaw".
at: Boston

Aoopyisanloaed.

Per-Inpaﬂxismaterialmayperfomaserviceasasupplenmt

or-spscialsaotimofﬁnmm

Jamaal. 06 PAycuauy.

Similar

domrrtshavebeenpmpamdbyoﬁmtmtmedisu'ibutimm
usuallybochlooalmd,withﬂ1erumdintomstinmilatwal
ECI',

mammaysmauscful purpose, particularlyin

psydmiatrictxuiningpmgum.
'man‘k you for your midmdm.

Stanly youm,
Max

Fink,

M.D.

Nasser of Paydliaty

�</text>
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                    <text>July 31,

1969

Dr. Herman C. B. Denber

Marimttan State Hospital
600 East 102th Street

M'sYork,Island
Nae York 10035
New

Dear Hy,

Attadied is a protocol of a proposed study. I would be pleased
discuss
this with you next week and look forward to having you
to
the
visit
Departnent at 5 East 102nd Street, on Tmrsday, August 7,
lunch.
noon
for
at

Simmly yours ,
Mm:

Firﬂc, M.D.

Professor of Psydxiatxy

M‘dcp

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Dr. Stephen B. Bernstein
Prom Head, ECIEUResearch Brand:
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National Institute of Mental Health
susu Wismin Avenue
(navy (Jase, Maryland 20203
Dear an. Bonntein:

gentWkamWﬁmeuﬂt.
iaaomﬁnmtimofstudieabe atliﬂlsideﬁospital
in "DB md Hum: Payctqhmmﬂogy"

The

(PH—13358) and

(mm-1962) (PH 927, 2715, 2092, and at the Miwcﬁri Institute
of Psyd'tiatry (1962—1966) (Hi 08517.11380 11381) and in

ofde

is focused m
and in this
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pmvidem oppwumitymdimaﬂmdhecﬁamwemm
mtakhm.1m.11dbepleasedifymwmldjoinhim,mﬂ

useﬂmoooaaimtobecmaaoquaintod.1tmstwecmmt

befmtlufallnmhofnnatirga.

Sincerely yours,
Max

Pink,

M.D.

meesaar of

1mm

Psydmiatry

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Ir. Juana

Lavina

Psydloprmnacoloy Research Brand:
Realm
Natimal
of

Imam

mm

susu Wiscomin
Chevy (Jame, Maryland 20203

DearJeny,

Itism

BmloeediaamBCﬂlJmportfw 1968-69.
mivaﬁmmsmtedinJm,sime itpmwidesaview

ofqmproyessaamllasﬁndimctiamwemmwtaldng.

Itmﬂdbetnlpfulformmrwiwmaedatainam

1mm,mshmeyuma¢pwimmtopmvideaﬂxm
basis

fwtluEEGmdﬁmPsycthm(m~13358).

leditbepossibleforymtospendsmtﬁnewimus
ﬁxinsxm,befmthefa11mmdsofmetingasetin? I
willcallyatmofﬂceinafwdays.

Imivedahmﬁmm.3teplm8mmin,mdin

viwofmmlninﬁwECDmpmgrm,Imseminghimacopy
ofﬂxismpwtandwmldb'eplmedtormhimjoinym.

Ilodcforwamtqumvisit.
Sincerely yams ,
Max

m,

M.D.

Professor of Psychiatry

Mszp

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                    <text>AuguAt 4, 1969

m.

3):.

c. J. “Dream
o
gloat chumility

06 ktheno School 06 Medicine

Unlv

, (609), Gneece

Goudl,
Deon

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The National

Imtbmte

05 Mental Health has nevteuved

magma

pooelandhutoldmthottheywouldléheaﬁouulcomctumn
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data somzbmaeton 05 such a mopoaal, we one (nee to

no

boonaewe

make

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owe duwolom.
seam
sent to you 60" gown Wm.

I have began an outline,

Began. then. ltwowld be

anamtothe 50mm

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will be

helpéullé youwouldeendmeaaumym

quutéom:

l.

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chant eunuculum vltae (binth date, ochoolo, degneeo,

2.

A

we 05 peneonal publicatlom Icelated

3.

A

peuent appotmnu)

ohont (one-page) ouumy 05
mjew. I

lncltwtlng the on-golng
deemécel and bonded.

my help

4.
«A

“pew.

We

to cannabu.
you wank tn cannablb
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Themandcumculumvuaeoﬁ aGneeh psychéoMtwho

in .(ntuulwtng the Aubjeeu.
vitae
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dame

5. The

05 Die.

Steﬁam’t.

the phopobal with m. Steam again, to cum
coopmtéon, 504 we will have to use has labonatohy!
me
Incldentally, I had dlsﬂculty tn neacht'ng 011.. Sheldon Slegel a out
yowL
dld
to
caution
get an
Populotlon Council, but Wally
not
sud/Lu with cannabu. They
Auppant {on

(0on

you
yowueld (on me) 05

w

am m mad
aha-5W
atpment, butwhen I mueeddtemwbdtﬂze novelty o6 theldea, hedtd

done and.“ ltahowed anytntueaténg Mugs,
apuotamdyme
eaythattﬁ
wank.
They wggested OIL. John 9mm 05 the
would nevlew the

they
0‘ outer/«lea ln Athem (25 Val. Sophia) M anlnveotigotoh
could Aupply the neceuang coltcbonatlon.
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ha beet mm,

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                    <text>August 6. 1969
Dr.

Fritz

Freyhan

New

York.

New

St. Vincent's Hospital
153 West 11th Street

Dear

York 10011

Fritz,

Enclosed are some notes and the reprints I borrowed
The budget may be too big. but
represents the true costs today. It can be scaled down.
of course. and I can suggest where paring might be done.

it

from Dr. O'Connen.

Thank you for the opportunity to read. what is to me,
s new and interesting aspect of psychiatry. I trust these
cements are helpful.

If you are able to pass the em on to a granting agency,
fees are SSO/hour end this required about 5
consulting
Ache
ours.
My

best to

Dr. O'Conne'ii.
Si ncere'ly yours .

Fink. M.D.
Professor of Psychiatry
Max

HF:kp

enc .

�</text>
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                    <text>August 6, 1968
Dr. Gaston-Germain Trigos

“yeth Laboratories
Box 8299

Philadelphia, Pennsylvania

19101

Dear Dr. Trigos:

It was a pleasure to discuss studies of WY 3263 and WY 4036.
have had the opportunity 00 review the data submitted and
believe we can contribute to your study program.

We

WY

These

4036.

initial reports

of this novel

compound

report anti-anxiety
properties. Most unusual
is the report of amnesic properties in patients.
I reviewed the available EEG data, seeking a better definition
and anti-convulsant

its neurOphysiology. Motor activity in mice was suppressed, with
4036 being 100-200 x as effective as chlordiazepoxide. The EEG
activity in cats showed a "decreased frequency and further spindling"
at intravenous doses of 1 mg/kg to 4 mg/kg. It is reported an
of

WY

exceptional anticonvulsant, particularly against metrszole.

of

The

clinical data reports ataxia

and sedation during administration

ng/day oral, and nervousness, insomnia, diarrhea or constipation
two to three days after cessation of NY 4036.
5—10

Two studies are suggested in the pppulation available in these
laboratories.

l. EEG Profile. As indicated, we find the EEG profile
in volunteers, supported by similar data in patients useful in
classifying new psychoactive drugs, and identifying target populations.
If a parenteral form of WY 4036 is available, an EEG profile study
can be done rapidly, and a suggested protocol is enclosed.
If

can be done but

only an oral form

is available, a similar study
extensive material and allonger
protocol indicates the differences in

requires more
it The

period of study.
design in the supplement.

�-2~

Dr. Trigos

WY

2. Clinical trial. The anti-anxiety activity of
4036 should preperly be tested in a wide variety of anxiety

subjects.

Our ongoing

4036

studies of anti-anxiety agents in a

clinic population permit the introduction of
in either an open study or a random comparison with

mental health
WY

August 6, 1968

chlordiazepoxide (our present standard).

I would also suggest that a study of the sedative
effects of WY 4036, especially its effects on the sleep - EEG
("sleep~prints") be considered. The data cannot be collected
in my laboratories, but we are uniquely equipped to analyze data
recorded carefully elsewhere. The data can be collected in
collaborating laboratories, and if this is of interest, I will

be glad to provide the

”mm

”mal75

details.

WY 3263.
The extensive trials already completed are clear
and the new efforts that may be necessary for a better delineation
of clinical applications may come best from the extensive clinical
crisis”Vhen;gwb‘ prindole is released. The data does not include
reports of EEG examinations. These would be useful to define the

neurophysiologic basis of the clinical response. In the facecftthe
extensive clinical data, perhaps such data would only satisfy our
scientific fancy.
An EEG

yet be useful in completing the
be
assessed
in a fashion similar to
so, can

profile study

submission, and

if

may

that suggested in the protocol for

WY

4036.

protocols are enclosed, for an EEG profile analysis and
a clinical trial of WY 4036. Protocols for a sleep-print EEG
study of WY 4036 and an EEG profile of WY 3263 will be provided.
Two

Thank you

material.

for the opportunity of reading this interesting
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August

ll.

l969

Dr. Allen P. Burger

Associate Director
Department of Clinical Research
Chas. Pfizer a 60.. Inc.
Groton. Connecticut 06340
Dear Dr. Burger:

for thiothixene oral concentrate
considerable interest. I have reviewed the
clinical data and find that the data is consistent with the
following conclusions:
The

NBA

was read with

summary volume

l. Thiothixene concentrate is an active psychoactive
the patients exhibiting decreased psychotic symptoms.
parkinsonism and sedation. These features were reported in all
studies in which daily doses above 20 mg/day were used. The
agent

«-

symptoms were equivocal

at lower levels.

2. The two studies which compared the clinical
efficacy of capsules thiothixene and oral concentrate reported
similar clinical effects at comparable dosages.

a

-

3. Tables of the reported secondary effects of both
patterns of

forms (capsules and oral concentrate) show the same
effects with a similar incidence.

Furthermore. the dosages. clinical and secondary effects of
the reports of oral concentrate are similar to our own studies of
thiothixene in capsules reported in l967. and I would have no
hesitancy in undertaking clinical trials of the concentrate
in treating schizophrenia at dosages comparable to thiothixene
capsu es.

-

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>August

ll.

l969

Dr. Allen P. Berger

Associate Director
Department of Clinical Research
Chas. Pfizer a 80.. Inc.
Groton, Connecticut 06340
Dear Allen.

Enclosed are two copies of the study "Assay of Oral
and Capsule Drug Dosages by Quantitative EEG

ﬁancentrase
r ter a.
we

have begun the data

run through Saturday of

this

collection this
week.

morning and

will

Since the meeting of the FDA is not until next Thursday,
I believe you will have more material with second trials as
of Monday afternoon. Our schedule calls for twelve subjects
to be tested Monday-Thursday with their second testing on

Friday. Saturday, Monday and Tuesday and their third testing
during the remainder of that week.
Also enclosed is a letter regarding the review of the
thiothixene oral concentrate HDA.
My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF2kp

enc .

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                    <text>August 12. 1969
Mr. Robert Mariin

Sandoz Pharmaceuticals

Hanover.

New

Jersay

Dear Bob,
we received the material shipped on July 28 on August 8.
Sines one bottle is sufficient. I am taking the iiberty of
returning the second set.

The

study wili begin within the next.week.
Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 12, 1969
Dr. Hilliam C. Janssen

Lakeside Laboratories
Milwaukee, Wisconsin 53201
Dear Dr. Janssen:

pleased to send the two reprints which you have requested.
The chlorpromazine-imipramine-placebo study in depression has
since been replicated by NIMH and you may be interested in the
reports which have appeared, written by Dr. Raskin. You may
wish to obtain some of the preprints from him directly.
I am

antidepressant study which you suggest
sounds interesting, but we do not have available a population
of chronic} depressives. Indeed. it is difficult to find
investigators who have such populations at their disposal.
The comparative

Have you

thought of undertaking such

a

study overseas?

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC.

�</text>
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                    <text>August 12. 1969
The

Institute for the Study of

Drug Dependence
Chandos House
2. Queen Anne Street

London. Hlm 08R. England

Gentlemen:

are planning a conference on cannabis and in writing
to the Ciba Foundation regarding their recent guest meeting.
they directed us to you. He would appreciate a list of the
participants at the Ciba meeting on the botany and chemistry
of cannabis and the titles of their presentations. This would
be helpful to us in planning our conference.
We

Sincerely yours.
Fink, ".0.
Professor of Psychiatry
Max

Mszp

�</text>
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                    <text>August
Dr. S. Clydo

l2. l969

Strickland

Merck Sharp 5 Dohmu

west Point, Pennsylvania 19486
Door Clyde.
would

for you to provide clinical supplies
it be posslblo
(Curprlmine) for clinical trlal? May I

of-pcnlclllamlne
requcst 1000 capsules (200 mg)?

If plocabo penicillamlno is available, it would be most
helpful for us to have an equivalent amount for induction
purposes.

Thank you

for your cooperation.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

HF

:kp

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                    <text>August 12, 1969
Dr. William L. Simpson

Detroit Institute of Cancer Research
Division of the Michigan Cancer Foundation
48ll John R Street
Detroit,

Michigan 4820l

Dear Dr. Simpson:

are planning a schedule of meetings for the fall
would be helpful to have the specific dates of
the next meeting of the AIRI. Your letter of May 23
would be held in New Orleans in October
indicated that
and we would like to send a participant.
We

and

it

it

Sincerely yours .
Fink, M.D.
Executive Director

Max

MF:kp

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                    <text>-v—yrm

..

an...”

N

_.

pm...

August
Dr. Thane:

l2. l969

Hillim

western Pennsylvania Psychiatric Institute
University of Pittsburgh School of Medicine
Pi ttsburgh. Pennsylvenie
Deer Ton.

is e copy of 1: manual which we heve recently
Since
coupleted.
you were instrumntel in helping us with
I
this project an pleased to send you e copy.
Enclosed

my:

It was

w.

«,1

swarm

a pleasure having you
your new program is going well.

visit

us end I

Sincerely yours .

MM

__

.

Fink. ".0.
Executive Director

NIX

,szu-gnu

mu:
enc.

;
:i

E

'

trust that

�</text>
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                    <text>August 12, 1969
Dr. John c. Kramer

Assistant Clinical Professor

Orange County Medical Center
lOl South Manchester Avenue
Orange. California 92668
Dear John.

September 12 is a better date for me. I am leaving for
San Diego on the 6 o'clock flight and would be pleased to see
you in the morning.
Stan

is

soon as he

away

but I will have him get in touch with you as

returns.

be in San Diego from the l3th to the l9th and if
back.
perhaps it would be fun to visit Irvine on
you are
TUesday, September 16, where they allow us a free afternoon.
I

will

I look forward to seeing you.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

iii-Elm

�</text>
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                    <text>August
Dr. Thomas Williams
Western Pennsylvania Psychiatric

l2. l969

Institute

University of Pittsburgh School of Medicine

Pittsburgh, Pennsylvania
Dear Tom.

Enclosed is a copy of a manual which we have recently
completed. Since you were instrumental in helping us with
this project I am pleased to send you a copy.

It was

a pleasure having you
your new program is going well.

visit

us and I

Sincerely yours,
Max

Fink.

M.D.

Executive Director

MF:kp

enc.

trust that

�</text>
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                    <text>August 12. 1969
Dr. Martin Katz

Clinical Research

Branch

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Dr. Katz:
program of the evaluation of unilateral
prepared a manual of procedures and I am pleased
to enclose a copy for your information.

part of our

As

ECT. we have

This was prepared in response to a request by Jonathan Cole

after

I gave a

lecture at his hospital last

summer.

Williams had been the monitor of our project study.
have
a replacement?
you
Tom

Do

My

best regards.
Sincerely yours.
Max

Fink.

M.D.

Executive Director

Mszp

�</text>
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.

,

vr—vw;::mw:~I-'&gt; mm wwu'

m

.

Mr. Daniel North
Local 1199 News
709 Eighth Avenue
New York, New York 10036

,

'

“'"w #3»

'

unwr-

October 7, 1969

.

Dear Mr. North:
I regrot that it is outside of our usual policies to
allow photographs of the treatment programs of this Department.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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'

rmww'aw's

October 6, 1969
Dr. Max Helfand
65

New

Central Park
York,

New

West
York

Dear Max,

Enclosed is a collection of reprints of studies completed
during the past many years. These are the basis for our present
study program in convulsive therapy. When you have had an
opportunity to read these please call my office.
I would appreciate your

returning this.
Sincerely yours,
Max

Fink,M.D.

Professor of Psychiatry

Mszp

ruwr-

mum-u

v-

mm

�</text>
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August

RF.

The
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.

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Institute for the

l2,

1969

Study of

Drug Dependence
Chandos House
2. Queen Anne Street
London. Elm 03R. England

Gentlemen:

""‘7

:‘WWF"*

“(Ira-TYg‘UpR"

We are planning a conference
on cannabis and in writing
Ciba Foundation regarding their recent guest meeting,
the
to
they directed us to you. He would appreciate a list of the
participants at the Ciba meeting on the-botany and chemistry
of cannabis and the titles of their presentations. This would
be helpful to us in planning our conference.

Sincerely yours.
Fink, ".0.
Professor of Psychiatry

Max

MF:kp

w

:‘z'y

NZWPWJ'NM‘Q’JF'W‘Wgyr"

‘

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("K-a».

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                    <text>August 12. 1969

Leonide Goldstein,

do

New

0.5:.

Jersey ileum-Psychiatric Institute

Box 1000

Princeton,

New

Jersey 08540

Deer Dr. Goldstein:

Enclosed are the reports which you requested. as well as
the paper listed es 47 in the EEG review. I trust those are
helpful end I look forward to reading your report.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Hex

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                    <text>August 13, 1969
Dr. Dirk Krﬁnig

Bucklestrasse 1-5
Konstanz, Germany
Dear Dr. Kronig:
We are
a get together in New York after the
EEG Meetingsuof investigators interested in
Internationaplanning

EEG

as a

and psychiatry.

participant.

I look forward
September 25, 1969.

A

Dr. Kunkel has suggested your name

formal

letter of invitation is attached.

to geeting

you in our

laboratories

Sincerely yours,
nt‘

a¢Lg KL gu48

Mszp

Fink, M.D.
Professor of Psychiatry

Max

aéycat

on

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                    <text>August 13 . l969
Dr. H. Penin

Univ.-Nervenklinik
Bonn, Germany

Dear Dr. Penin:
We are planning a get together in New York after the
International EEG meeting of investigators interested in
EEG and psychiatry. Dr. Kunkel has suggested your name
A formal letter of invitation is attached.
as a participant.

I look forward to meeting you in our laboratories on
September 25. l969.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

NF:kp

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                    <text>August 14, 1959
Dr. S. L. Viaser

Valeriuakliniek

Amsterdam, Zuid,

The Hetherlando

Dear Dr. Victor:

are planning a get together in How York after the
International EEG Meetings of investigators interested in
EEG and paychiatry.
Dr. Sugarnan has suggested your name
as a participant. A formal letter of invitation is attached.
We

I look forward to meeting you in our laboratories on
September 25, 1969.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

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i

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V

August 14. 1969

Valoriuskliniek

g

Amsterdam, Zuid,

E

The

j

Dear Dr. Viaaar:

E

E

i

ara planning a sat togathar in How York aftar tha
Intarnational EEG Haatinga of invoatigatora interested in
EEG and psychiatry. Dr. Sugoruan has suggested your nana
as a participant. A formal letter of invitation is atlachad.
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F

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n,

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Fink.
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�</text>
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                    <text>August 15. 1969

Dr. Manuel

M.

valance-Suarez
de Neurologia, 8.8.A.

Instituto Nacional

Haxico, D.F.

Dear Dr. Velaeco-Suarea:

I

in the

am

pleased to accept your kind invitation to participate

"11

International

pharnacology" in

thico

Seminary of Psychophysiology and Psycho-

City, December 1-6, 1969.

I read the outline of the proposed program, I believe
presentation would be more appropriate in the section
on neurophysiological correlation: or even brain mechanisms
and behavior. I would propose to present our investigations
that

An

my

of EEG effects of psychotropic drugs and the use of EEG data
to identify and classify new psychoactive compounds. Perhaps,
for this meeting, our experiences with phantaatica - hallucinogeno.
deliriants and opiates ~ may be of particular interest. If so,
I would suggeat the title "Neurophysiology of Phantaotica".
Thank you once again for your kind invitation and I look forward
to seeing you in Mexico City in December.

Sincerely yours,
Fink. HOD.
Professor of Psychiatry

MIX

MF3kp

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                    <text>August 15. 1969

J. Cohen, 3.x.
Dirsctor, Departmsnt of Education
National Association for Practical

Miss Michelle

Nurse Education and Sarvica

1065 Broadway

New

York,

New

York 10036

Dear Miss Cohan:
Thank you for your invitation to participate in the program
on my calendar and I
on wsdnasday, October 29. I have marked

it

will be pleased to present our experiences in the treatment of
opiate addiction at 2:30 p.m. at the Starler Hilton.Hota1. I
will try to adiond the meeting early enough to hear Dr. Brill.
A copy of my curriculum vitae is enclosed. my present
identifications are as Professor of Psychiatry, New York Radical
College and Director, Division of Biological Psychiatry.

Sincerely yours,
Fink, M.D.
Profcaaor of Psychiatry

Max

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                    <text>August 15, 1969
Dr. Edgar Grunwsldt
Gutsy Pharmaceuticals
Ardsley, Raw York
Dan: Edgar,
May

I please have an additional supply of 1miprsnins

for the ketimiprsmins—imiprsmins study.
attached.
is
12 x 100
my

A

beat regards.
Sincsraly yours,
Fink, M.D.
Professor of Psychiatry

Bax

label

�</text>
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                    <text>Wm

~241¥|m¢V~n .w

'Wmivpni.1. n

.

-»--.»;

~

rum.» gum—w»-

r.r),v (”yam-r- .

,

.n.»

.-.,.-. .«.~,.ym.. 4,77,“

_.,.,.mwnr,mwr

ng

.../

.

‘

August 15 . 1969
Dr. Daniel P. Bobon
University of Liege
Clinique Psychiatrique
Rue Saint-Laurent, 58
Liege. Belgium
Dear Dr. Bobon:

I am writing in reply to your letter of July 16 and I am
pleased to have you spend a month in our Department in the spring
of 1970. It has been my experience that observers who wish to
understand our methods find them confusing until they accept the
responsibility for a specific study and attempt to carry out the
steps necessary' to write a protocol, collect and analyse the data
and write a summary. Some visitors have joined my Department for
a few days and this has given them sufficient opportunity to take
back with them an overview of our methods and facilities and attitudes.
While I would welcome you for a month, I must caution you that
this time is long as an observer and much too short as a participant.

of

Unfortunately,

we do

not have funds available for the support
on an annual basis. In the event that

visiting scientists except

you are interested in coming for a year,
on your behalf to a number of agencies.

I

visit,

I can nuke an application

to consider an application for e year’s
as thia‘will be the best for your program.

would urge you

For funds for a shorter period may I suggest you apply to
or WHO. Scientists have been sent from Europe to laboratories,
including my own, by WHO. Applications are made by the European
scientist and the roquiresent for us is to welcome them.

UNESCO

My

best regards.
Sincerely yours.
’4‘! Fink.

MOD.

Professor of Psychiatry

�</text>
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                    <text>w.

9.0“...” ,euu‘ :1 up

«xruw.:r.~,~m

:3

v.

.. ,«4r~lw.vﬁw-

.7.,..

..

.....‘-w;.‘.=.:ww

1.

..

W'aﬂ(‘

A-wwn

q,—

-

7.3

7

August 15. 1969
Dr. Gaston Costellonoo
Institute National do Hourolozia
Insurgentea Sur No. 3877

Enrico 22, D.F.

Dear Dr. Costellanos:
some mail with your letter. I rocoivnd the kind
of
invitation Dr. Valance-Suarez to participate in the symposium
in Decedbor.

In the

I thank

you

participating in,
A

copy of my

for your

recommendation and
what appears to be, a most

letter

to Dr. volaoco~8unroz

I look forward to

interesting progrrn.

is enclosed.

Ilt would

be most oxciting to prepare a symposium on
ond psychiatry outing the Vth world Congress in 1971.

I look

forward to hearing from Dr. do

la Fuente and will

work with you in preparing an fino a program as

for

19710

we can manage

Sincerely yours,
Fink. 14.13.
Professor of Psychiatry

Max

Hrzkp

EEG

�</text>
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1
w”

m

whvﬂfuJJ'

August 15, 1969
Mr. P. Bergmans,

President
Eleevier Publishing Company
Jan van Galenstrant 335

P. O. Box 211

Amsterdam, The Netherlands
Dear Mr. Bergmana:

letter of August 5, has clarified the subscriptions to
Journal very well. The addresses are correct. I wish to
thank you for your cooperation.

the

Your

EEG

sincerely yours,
Fink, M.D.
Professor of Paychietry
Max

�</text>
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                    <text>August 20, 1969

Dr. Fritz A. Preyhsn
'

St. Vincent's Hospital
St.

153 What 11th

New

York, new York 10011

Dssr

Fritz,

IBM order shoots for the NYMC and tho
1800
computers. The differences in
St. Vincsnt Hospital
be
and
in memory may
significant for programming, and
speed
rocounondstion
that programming changes
for
our
for: the basis

Enclosed

will take

some

srs the

effort.

sincerely yours,
Pink, M.D.
Professor of Psychiatry

Mix

erkp

�</text>
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                    <text>Aunt-t 21, 1969
Dr. E. N. Oawald

Royal Edinburgh Hospital
Homing-Ma Park
Edinburgh 10, Scotland

but Dr.

Oswald:

m attached invitation was nut to a nuabar of paychiatriata
in July. 1):. Shaun, a what of my ataﬂ' visited your laboratoriaa
during hia holldaya and mutant! that you might be intaraatad in
attanding a

gating

of

this kind.

In tha want that you will ha in law York follwing tha
EEG matings, I will ba planed to valcoua you.

Intamtional

Sinatraly your: .

rink, 11.9.
Profane: of Payehiatry

Max

lump

_

�</text>
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                    <text>August 22, 1969
Dr. Enoch Callaway

Chief of Research
The Langley Porter Neuropaychiatric

401 Parnassus Avenue
San Francisco, California 94122

Institute

Dear Roch,

For some months, Dr. Jan Volevka, fornerly of the
Paychiatric Research Institute of Prague, has been.working
in my laboratory. He is anxious to visit some centers en
route to San Diego, and I have encouraged him to see your

laboratory.

trained, enthusiastic worker, with a keen
interest in quantification and clinical correlations. I
believe you will enjoy meeting him, and would be grateful
He

is

if a visit

a well

could be arranged.

He

I look forward to seeing

you

on September 10 or 11.

My

will call your laboratory
in

San Diego and

New

best.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Hrzkp

York.

�</text>
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                    <text>Angel: 22, 1969
Dr. George Gardoe
The Barton Mental Health Center
555 Horton Street
Beaten. Haaeaehueetta 0212A
Dear Dr. Gardoe:
we did eeaaure the EEG changes with thiothixane in 1966,
and found that, in chronic achiaophrenica, in doaagee to 30 nglday.
EEG ohangea of increaaed theta dacreaaed beta and decreased alpha

were frequent. The ehangea were not ueaaured quantitatively, for
did not do a controlled atudy of thiothixena.

we

Recently,

we have begun a

quantitative etudy of thiothixene
in volunttere
thie ie in progreaa. The EEG changes are aieilar
to theee in patienta.
and

"state of
the art" today. If you viah to vieit my laboratory, I would be
pleaaed to diacuaa your project in the light of our experience.
Encloeed are aoaa anaeary reports outlining the

Sincerely youra,
Fink. H.D.
Profeaeor of Peyehiatry

Max

Hizkp

�</text>
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                    <text>August 22, 1969
Dr.

Jhstns J. van

Gounod

Dspsrtsont of Psdistrios
University Hospitsl
Laidsn, Tbs thhsrlsnds
Dos: Dr. vsn Gounod:

Enclosed or. soap reprints describing our work. Thsss
should provide tho basis for sun. oollstorsl rssding.

I would-ho pleased to hsva Dr. Hbchslse visit my laboratorﬁns,
call (212) 369-7900. arrange-onto will bo node.
The subject that interests you is under sctivo study in
s few laborstoriss. Mhy I suggsst you read the reports of
and 1! ho V111

.

"ﬁn"

mw

Peter Kallsway of Houston;
of Chicago; and

G. Lorry

G. Psnpigliono of London; John
of Paris - to nsnn a few.

sincsrsly yours,

uw-ku—vw

Truvv

as: Pink, 3.0.

Professor of Psychiatry

warrmW

ungw,

MFskp

...~

,V

A

Inc. l128,117,101c,90

Hughso

�</text>
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                    <text>..-.

r
”w.

..

.v—qurww,

August 23, 1969
Dr. Allen Berger
Chas. Pfizat &amp; Co.

-

Groton. Connecticut

Ref: 0? 14»368

Dear Allen,
We

have completed an

initial act

in volunteers, in single eral dosages of
was in a single trial.

50

to

of

trials

of

350 mg. Thu

CP—14,368

latter

dose

To daca, nu have failed to obscrvn behavioral or EEG effects
during tha initial 2 hour obnctvation period; and the subjects reported
no behavioral consequences for the ensuing 12 to-ZO hours.

continue theta trials, we wish to ameﬁd the protocol
earlier, to allow trials (single, oral) to 500 as.
T6

submitted

Pleaae verify.
Sincerely yours,

Max

Fink, M.D.

Professor of Paychiatry
mf/

�</text>
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                    <text>August 25. 1969
Br. Barbara 8. Brown

Chiof. Exporinaotal Phyaiology
Vatarana Administration Hoapital
Bapulvada, California 91343
Boar Barbara,

I had already anaworad tho firat call for intaroatad
participants in the "Foadback Society," but van ploaaad to
receive your lattar. I think tho idaa ia a good ona particalarly in EEG. whore tachnical breakthrougha have
ovarahadovad concoptual. The faadbaok nodal to vary intaraating
to no (Stan Paldatain, J. Volavka and ayaol!) and while
wo hava not approached tho EEG from thia point of View,
we have made one aoaay in a machaoical model of tho EEG
response to pantothal. Perhaps Stan Yoldatain has sent
the preliminary draft to you - if not, I an anclooing a
copy.

I an ploaaod to join your society.
I cannot attend the first matting but hava asked Dr. Stanldy
Foldatoin, Ph.D. to do so.

If you believe tho enclosed report
praaaot the material in 10-15 ainutoa.
Thanks, again. for the

is of intaraat,

invitation.
Siocarely yours,
NIX

F1“,

£101).

Professor of Psychiatry

Mr:kp

cc: Dr. S. Faldatain

ha can

�</text>
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                    <text>August 25. l969
Dr. ii. J. Russell Taylor
American Medical Association

Clinical Pharmacology-Toxicology Center
Philadelphia General Hospital
Philadelphia, Pennsylvania l9l04
Dear Dr. Taylor:

Enclosed is a draft copy of our report to the A.M.A. on
July 14. It represents a distillation of our experiences with
the antagonists oyclazocine,and naloxone. and with tybamato
and methadone. The data is not original. and it should be
considered for what it is - a summary of experience and
published reports. Thus, publication as a special summary
may be appropriate; but not as an original article.

It was a pleasure to participate in the symposium. I
also pleased to read that the AMA voted to allow specialty
sections to continue responsibility for the meetings. This
should stimulate better programs.

was

My

regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
BBC.

�</text>
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                    <text>August 25, 1969
Dr. Carl C.
new Jersey
Box 1000

Princeton,

Pfeiffer

Neuro~Psyehistric Institute
New

Jersey

Dear Carl,

-

EEG
You may recall our discussion of pyrovslerone
and
a
in Miami. 1 undertook the single dose~pilor study,
This
information.
for
enclosed
your
is
summary
preliminary

study followed our usual procedures, to define a minimsl
end/or EEG
effective drug dose which elicits behavioral
EEG
changes in the time period of our usual EEGstudies. The
profile study.
data is sufficient to allow s definitive
Copies of this summary have been sent to Turen Itil
end to Dr. Boyer of Nsrion storstories.
Trust you have had e healthy and relaxing summer.
My

best rugsrds.
Sincerely yours,
HI: Fink. MJ).
Professor of Psychiatry

ﬁrzkp
Cm.

�</text>
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..

,.

:w-z

-

nm‘d"-’:‘,K‘.mmev:uu:v.~vamy ,- falan' “um

m—

wow‘

—

I.

m

"J‘ -.”maﬁa-urnzvavwr. (.73.... r
.

.

v...,r.,~-«..r_..

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7..

7,.

August 25, 1969
Dr. Philip A. Boyer,

Jr.

Motion Laboratories. Inc.
10236 Bunker Ridge Road
Kansas City, Missouri 64137
Dear Dr. Boyer:

is the ounnary of the pilot pyrovaleroue ~
EEG study in volunteers. The data is sufficiently clear
to answer the questions set for this study, 1.e., behavioral
and EEG affects aro readily apparent at 160 mg pyrovalerone
(single dose) in normal, adult volunteers; and that this dose
Enclosed

is safe

and

well tolerated.

I have sent a copy to Drs. Itil and Pfaiffer, as I had
promised in our initial discussions in Miami in December.
any

After reading this summary, would you call

additional data
my

you may

me

regarding

require for your records.

boat regards.
Sinceruly yours,
I'm Fink. 14.3).
Professor of Psychiatry

Hrakp

one.

“,3.

._v

v,“

A.

7...... ...

»...

.1...

r...

.

.3.“

5.

._WV_

�</text>
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                    <text>August 25. 1969

Dr. Turin E. 1:11

Missouri Institute of Eoychdntry
5400 Axlonal Street
St. Louis, ”issuer:

Boar

63139

futon.

Ht have cooplotod our phaao I study of pyrovalorono.
rho conclusions arc summarizod 1n the enclosed report, aunt
to Dr. Boyer. the EEG macorlnl shows pyrovalorone to havo a

,.

,

wwgyxwu

umwvw—z—e—w—av

pattern similar to tho anphotaninos. but
deflnlttvo study.

must depend on a

its classification

An wo had discuased in Hiaml. I am oloo sanding a copy
to curl Pfeiffar. If a collaborative clnnaiilcation study
wore dons wn would rooiunond clnslo 160 as dosages. and
other conditions, as describod on page 5.
‘

—

Hy

but: regoxda.
Sincerely yours.

-mwn

x
-

HI!

’1“.

”OD.

Profoaaor of Psychiatry

Misty

cc: Dr. Boyer

�</text>
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                    <text>August 25. 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Dr. Harrison:
Our initial trials with GP 41,299 have progressed well.
In 15 trisls in nor-a1 volunteers, we have used dosages of
25 to 200 mg. The observation period of EEG and behavior
has been 1 1/2 hours. we have also obtained the subject's
reports of the succeeding lé—Zh hours.
and

for

day.

behavioral effects of sedation, drowsiness
100 33. These symptoms persist
hours. the subjects reporting sleeping late the next

we have observed

lsssitude at dosages over

many

The EEG changes

are defined as increased theta and some
and a decrease in amplitudes.

delta; reduced beta activity;

These preliminary data are insufficient to classify 6? 41,299
but do provide the basis for the second phase study as outlined
in our protocol. Before undertaking this study. however, I an
anxious to check s few records at a longer time period (4 hours).
As soon as these trials are completed, I will send you a revised
part 2 of the protocol.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Hrzkp

�</text>
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                    <text>my \v—n—w-muwy

“ﬁg...”

\m

"WW“"U‘W-W"

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A

new: :AWW-rw-vn mug-skumw-wmhpmwmrnuurrmm-m-gp. Mme-mun. “w

u.

—

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,

.,

.

.

.‘m

.

Augult 25, 1969
Mr. T.

J. Israel, Jr.

Vandcn Brooch, Licbcr &amp; Cal
125 Maiden Lane
Now York, New York 10038
Dear Tod,
would you please confirm directly to our auditors,
Pancth, Hubs: and Zimnorunn, 135 East 42nd Stroot, New
York, How York 10017, the following information as of

June 30, 1969:

1. Security position,
2.

My

Y,

,.

A...&lt;-,__,.~..W

.,

A

Any

if

any.

fund: due you and due us.

Ito-pod oclf~addrloood envelope

your conviouco.

is enclosed for

,,__........

Sincerely yours,
Mu rink, NJ).

Exlcutivo Director

HFskp

.

V

,
.A

.

n.

.

..“.‘......,V..,..\..,..‘

.....

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�</text>
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                    <text>mwvsr-kuw—wﬂ

7...“,

v-v—nv

-.-r,,~.wv‘,....._..v.r,....

.

.,.,

August 26, 1969
Mr. Herman Heisman
Hoffman La Roche. Inc.

Nutley,

New

Jersey

Dear Mr. Heisman:
a pleasure to have you and Mr. Billig visit my
laboratory last week. The questions you raised, whether
objective drug specific patterns can be defined for Librium
is challenging. Specifically. you asked whether neurophysiologic

It was

indices could distinguish Librium (in therapeutic dosages)
from barbiturates (e.
phenobarbital)? Your reference to
..
define
su
to
failures
patterns in prior animal studies suggests
the difficulty of the problem.
There is some evidence that such a discrimination
feasible through quantitative EEG measures.

may

be

quantitative EEG studies of anesthetics, Belleville
in
specific responses for different anesthetic
Studies of amobarbital by
the
barbiturates
agents, including
1.

1n

1956 showed frequency

Shagass and of pentothal by Goldman and ltil showed frequency
specific curves for these compounds in mentally ill subjects.

2. Recent quantitative studies of pentothal developed
mathematical
a
expression for the EEG response (see enclosed).
This curve differed in patients receiving a phenothiazine from
those receiving placebo, suggesting that drug interaction in
the CNS may have altered the parameters of the expression.

profiles of Librium and Valium are similar
In our study of diazepam, imipramine and
placebo. our techniques classified diazepam. and this pattern
dhffered from imipramine.
3.

The EEG

to barbiturates.

techniques used in these studies represent the
available
best
today. In addition, instead of using a period
model. the more refined power spectrum
reduction
data
analysis
could be applied for greater resolution. Using power spectrum
as a back-up, I believe it should be possible to define EEG
profiles in volunteers. This could be attempted with either
oral or intravenous preparations. Two courses are suggested.
The EEG

�-2-

Mr. Heisman

l.

August 26, 1969

Oral study.

In an oral study, the changes in EEG may be defined
during l~3 hours post-drug using a period~analysis model.- The
first step would be a definition of “equivalent" oral dosages of
chlordiazepoxide and a barbiturate.x The equivalence may be defined
from the literature or in a pilot
byu33havioral criteria, either
s

.

In a definitive study. volunteers would return for 3-4
sessions. to receive in random sequence chlordiazepoxide placebo - barbiturate; and a second dose of chlordiazepoxide
or barbiturate. Data analysis would follow established univariate
(t-tests) for each variable at different times; or, a discriminant
fonction approach for split samoles ~ using l/2 the sample to
define the beta-weights and verification in the second half of

the sample.
2.

Intravenous study.
These techniques are more adequately

tested.

The

mathematical expression for pentothal has already been defined.

study of the

changes in volunteers receiving intravenous
would allow verification
of the pentothal curve. and a statement of the parameters of the

A

EEG

pentothal, chlordiazepoxide or saline
chlordiazepoxide effect.

Either study could

later this fall.

The

be undertaken in these laboratories
questions you raise are of theoretic

as well as practical significance.

studies

have been undertaken.

In

knowledge, no such
because EEG quantitative

To my

part.

techniques before 1963 were too inexact and unstable to be useful
for the fine discriminations required by your question.
Thank you

for the opportunity to review this question.
Sincerely yours .
Fink, H.D.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>August 27 , 1969

TOWITWCORW:
Fonmingtherequestofl‘b. J.

W.

StanciloftheBoard

of Veterans Appeals to Dean J. P. Eagle, Nov York Medical College,
the record of T. B. anday, C-‘W62879 was received for review
on 8/21/69. The record consists of depositions, military record
and

letters to

w:

and

has

V.A. claims

offices.

at the age of 30.
visual acuity defect, correctable to 20/1“).
Ming military service training, he claims to have suffered
a. fall on 5122/“, breddng his glasses, He was di
in June, 19m, A pension was wood, which on review 19“?
it»

Exaninat on showed

Monday enlis- ted 3/11/Im
a.

wasdeenedtobeinemcr, andmscirded,asthedisability
not service-mooted.

was viewed as

Claim: Progressive visual defect, aggravated by military
service, and yielding a state now of virtual "blindness".

ions: Mpsyohistricquestions misedbytimmﬁner,

Wmﬁmbasisofthemcord,mz

to

and

1. Does the veteran have a functional visual defect?
Diagnosis?

g3.

Data:

status.

Be

probable that it advanced during military
itservice
(19%)?

5.

Is

u.

Istheoowseofthedisozﬁermthanwmld
beacpected?

The record

is

is alleged to

have managed a fwnily type
Only one

sparse with regard to psychiatric

have completed hiya school; and

retail store prior to service.

psychiatric emiration

was found, dated

to

3/25/69, from the V.A. Center, Mountain Hone. Johnson City,
Tennessee: "...except for the possibility of fmctional
visual defect, he shows no recognizable evidence of mumsis

at this time."

�-2The depositions

present a

mixed

picture - loyal friends

citizens alleging severe interfermce with vision since
191m; entertainers finding a dissociation between his behavior
(in store, street, daily affairs) and the mninations, which

and

severe

show

bilateral acuity loss.

inion. The record presents no evidence for a hysterical ’
dissoEEEE’
state, and lends itself to the interpretation
that acting-out ("malingering") for secondary gain is likely.
of a detailed psychiatric exanination which
such
supports
a diagnosis takes the following opinions temnus.
The absence

l. 'Iheclaimantmyhaveafmctionaldisorder20
wiﬂxcm:

its rapid onset in

lean and persistence for
years
outward evidence of organic progressim are supporting evidence.
2. A psychiatric diagnosis is not possible on this
record; altlwugm psychosis, as camrticnnlly defined, is
mlikely. The absmce of evidence of neurosis, makes malingerdng
as well as an organic state more likely.

psychiatric state could have been precipitated
daring military service. 'Ihe very natme of the stresses of
service, the unconscious wishes to escape, the acceptance by
society of physical disorder as justification for military failure,
3.

A

andcoupensaticnlmsermanceandsupportthedevelcpmntof
corzversim pimmena and malingering. In addition, the
culture franwhioh Mr. Norway derives, may invest such in a
credible, aggressive military service; and Mr. Monday's apparent
"failure" could be excised, if it were mdically derived.

detemination of the presence of a conversion reaction or
"nialjngering" shmld be made by a psychiatric eminatim dedicated
to such a determination. The record by P. A. Vesey (3—25-69) is
béirtcaxplete for this determination, and a more detailed study may
A

advisable.
1+.

Thecomsecfthedisorderismtmusualfor

conversion reactions or mslingsring. , occurring in situations
where secondary gains are derived fron the conﬁrmation of the
disorder ~ as is possible in this instance.

I an Professor of Psychiatry,

New

York Medical College,

York University College of Medicine, 19%;
mediated from the
licensed to practice medicine in New York and Missouri; and a
diplomats in neurology and psychiatry of the American Board of
New

Psychiatry and Neurology.

Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

a as;

�</text>
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                  <elementText elementTextId="102973">
                    <text>August 28, 1969
Miss Eleanor E.

Carroll

Acting Chief
Center for Studies of Narcotic
and Drug Abuse
National Institute of Mental Health
5&amp;5“ Wisconsin Avenue
Chevy Chase, Maryland 20015

Carroll:

Dear Miss

questions of August 25 are most interesting, and
I can answer immediately.
I use cannabis as the general term for the plant species
and products to include marijuana, hashish, and themr extracts,
as the cannabinols. In a broad sense, the word can also "cover"
the synthesized tetrahydrocannabinols, if we assume these to be
related to the active principle of the plant.
1. Strength of cannabis. Two problems are involved ~
the cannabis used by the subjects for years, and their present
samples. Dr. Miras has assayed samples for some years now add
we will depend on his estimates of the quality available
of the subject's
historically. I expect that direct doassays know
be
done. I
not
present materials will
if a history of
cannabis quality during these decades can be compiled, but we
can attempt this. I will being your question to Dr. Miras'
some

Your

attention.

Definition of "Chronic". In Dr. Miras classification,
we are focussing on the B, 8-0 and C groups. The initial step in
the project is to identify the population and assess their reports
of cannabis use. The subjects introduced to me claimed daily
hashish use since their early adulthood, approximately 20-30
years. We will examine as many as we can and report their statements. "Chronic" will be defined by these records.
3. Sample size. Dr. Miras speaks of 200-300/subjects
in Athens. We would survey as many as we can, and study in
2.

detail 30-40.

�Miss

Carroll

August 28, 1969

~2—

Drug use forms. I will write to Dr. Miras
requesting a copycf his form. The DCMH form and our cannabis
inventory (derived from Haertzen) are enclosed.
Dr. Miras' classification does have "overlap", and he
emphasizes the fluidity of subject's use, allowing him to
classify subjects as A/B or B/C. Perhaps we will be able
to define these classes more satisfactorily. I expect it
to be difficult since it is likely that the reports by each
subject will fluctuate widely depending on their trust in us.
Our experience with Opiate addicts may be useful - for we
usually disregard the reports given initially, and depend

u.

more on

their later reports.
5.

Sibs and family members.

Yes.

Vilunteers. We wish to bring some subjects into
the hospital for testing; allow them to smoke their products;
and examine them for 2h~48 hours (or longer) thereafter. To
induce their cooperation, we will pay them for lost income pﬁus
a bonus for volunteering (plus, on occasion, money to buy their
hashish in quantity sufficient for trials and for assay). If
we get 30 subjects, it averages $100/subJect. This may be too
high, but we can report our exact costs and return any balance
6.

of the requested amount.

"Hashish'. In my initial interviews, I was
men claimed nbt to use alcohol or opiates.
We are interested in drug "associations" and
synergistic uses and will inquire, not only for their present use, but their
historical use as well.
8. Anthropological, Sociological Consultation.
This is a defect in the present proposal which may be remedied.
I am asking Dr. Feldstein to make the first examinations, and
he is aware of this issue. I have written to Dr. Miras about
this question, and he has yet to answer. You will note I
request funds for 2 consultants, and have named only one
(A. M. Freedman). I would like to consider, once our initial
data is collected, to ask Richard Brotman of the New York
Medical College to assist us.
Some forms are enclosed. The rest will follow as received.
Sincerely yours,
7.

impressed that the

Fink, M.D.
Professor of Psychiatry

'Max

Mszp

�</text>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="39082">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="39083">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102972">
                    <text>re

a..- 1.."

mas—u.—
,

"mm-W...”“m" :,

WW...

4vw—v '1"‘WVW1"H&gt;
i

1 :r. um ,_,»¢-

.u.

"WINK“Zhuuwn'ﬂmv—n-vwnvi
~~1wtcn¢ ...... «wavy-wane
4

.

.-—n ,
,

n... ..

,

..w .,:-» -

Ww'

rm sunmgv

w...-

u...» ”nun,“

.,., . _,_, ,, "nu-ww- vw.

1

,,

7v:

,-

WWI

v&lt;vugmvvzvu~m

i

:

T0:
FROM:

Adsinistration,

New Community

Metropolitan Hospital

Fink, M.D., Professor of Psychiatry

Max

SUBJECT:

Hental Health Center,

EEG LABORATORY

- Metropolitan Hospital

DATE:

8/29/69

mental Health Center

The development of a Community Mental Health Center

requires

the application of the best available methods of diagnosis and
treatment to reduce the time for treatment and improve the results of

interventions.

Based on

this premise, the Center is required to

have a diversity of services.
During the past decade, the role of brain function in mental
illness has assumed a greater interest and techniques measuring
and
changes in brain function have found application in diagnosis
management. The changes in brain function are measured principally
by psychological performance
Much
EEG

research has been done

analysis are

now

tests and by the scalp recorded EEG.
and clinical applications of quantitative

available in a

few medical

centers. In our Department,

analysis is available for research purposes,
has been limited by contracts to patients in the Narcotic
Addiction units and the Psychophsrnacology Clinic.

quantitative

The

EEG

and

clinical applications include:
1. Diagnosis of therapy resistant psychosis.
2.

Determination of adequate levels of antagonists in

the treatment of heroin addiction.
3.

Classification of brain injured children in the
Mental Health Clinic.

4.

Selection of drug therapy in psychotics.

..‘..‘-..... --- -

�"nu-rm
If the

m m,‘- ”mi—,ﬁﬂwmlw"
‘sw

.

equipment were available,

these lethods to

we

propose to apply

all pstients adnitted to the

Mental Health

Center, and for selected out-patients referred by the

staff.

Steffing funds already exist in the clinical staffing contrscts
available to the Department.
The

techniques used require careful recording of the

brain waves, storage
and

reporting.

The

tape, analyses by special programs,
individual pieces of equipment and their
on

functions are:
Electroencephalograph (Grass 78) and Couch: Used to
amplify brain waves.

The Grass

instrument provides signals

specially suitable for analysis since they
"chapper" type amplifier.

(The

do

not use

3

Offner, Medcraft, Gilson

units, although cheaper, are unsuitable).
Tape recorder (Ampex SP 300).

configuration, 1/2 inch tape.
analysis.

While Anpex

Seven channel,

Used to

FM—IRIG

store signals for

is reliable, other

vendors

may

be used,

as Sengemo, Honeywell.

Oscillator (Hewlett-Packard

2026K).

To

provide s standard

for tape units, especially for amplitude comparisons.

.-n»r.—--mv.w~-———.-~way—Fwwvuw‘

�“yaw-"T

-

I

A

.,m'—

A

V

my..."r.rwmmmMW—wqw—uuvww-«m-w—.m

vwn-a—Wn

&lt;w—w-w--—.—w-u~

wry—v»

Oscilloscope (Toktronix RH 564. dual channel). Monitors
the recordings on tape. Either single or dual been are satisfactory.
A

store's

scope

is necessary to allow its use also for photographs

of the analysed output.
IBM

1800 Process

power and amplitude

but

much

Controller. Analyzes

EEG

waves by

analysis. Other instruments are available,

less efficient. This device. though expensive, is

the one for which a library of programs has been written and
can be used immediately.

flexible

and

completed in

require
2

Other computer systems would be less

programming.

(Our programming has been

1/2 years.)

wm-w

w-vw

-r-

-1"

period,

Respectfully Submitted,
Fink, M.D.
Professor of Psychiatry
Max

�m"—

V

_

V

.1-I»'

“—3.2".

-

u-mv—nmz‘w—

EQUIPMENT FOR EEG RECORDING

Grass Instrunsnts
Quincy. Massachusotts

Roo- 4-17

1

console 7816p43.75 with 763800A-1230-16P

1

power supply 67RPS-A

1

Signal markers
8

HT7A

885.00

$

800.00
($165

as.)

botwson channels

and 9

165.00

8

Oscillogrsphs 6080 ($140 as.) with 1" spscing

8

830 Data

1

78MPRr8

1

678525-12 canneric pushbutton electrode

1

78THIEB ZO-N

amplifiers

1120.00

7P511A

3200.00

Master record playback

150.00

w”

,,

v—r-ﬂmrwzmyw—v

selector

400.00

high impedance electrodo board,

300.00

standard numeric

,_

--..

TOTAL $

.‘t-w-I-v-VWW'gw-vm‘

7020.00

.WA7F_

~._-_-w—w,&lt;

Room
1

.mrw..v~.—

é~17
Anpcx Modal SP-300 Record/Reproduce

1/2" wide tale,

»

7

track,

7

portable,

amplifiers

1

Mbdcl 704 Head degsnssor

l

Rsnotc control table top unit plus 30'

:Wwwm‘

8450.00

$

9.95
74.00

w

.-

cable Cat 596520-01

mum

&amp;

#4050100-10

-

m"

W1

TOTAL

—-

mmwm_mnmmlmww'r

1

Tcktronix dual bosn OscilloscOpe

1

Hewlett Packard Oscillator,

1

Inwood Couch H-4900, antique white (Scully Wslton)

RM

564,3A72, 2367

ZOZCR

$

8533.95
1250.00
330.00
144.00

�EQUIPMENT FOR

886 ANALYSIS

-u-———w—-

4-22

BOOM
~m-a-

rr'

may

.7,

.

One

rm...

-

IBM

1800 Process control system consisting

of:

m

WW

lSOl-Zcb

Processor controller

1816—1

Printer-keyboard

1828-2

Enclosure

1851-1

Mnliplex terminal

1856—1

Analog output terminal

23lO-A2

disc storage

1442—6

Card~read~punch

1443—1

Printer

Coat, single:

Approximately $168,000.

ZRWW”W"'

13w";-

rv-

”Ev-WW"

rwuwwrr-rv

m—u-wr-rpm

gwm

(For detailed specifications, ploace

call

Dr. Max Pink or

Dr. Donald Shapiro, New York medical College;
IBM,

or,

475 Northern Blvd., Great Neck, New York.)

Dr. Wayne

Joatrand,

�</text>
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                    <text>August 29, 1969

Dieter Bente
Universitat3~Nervenklinik
Dr.

Schwabachanlage 10

Erlangen, Germany
Dear Dieter:

is our

letter.
though
I had not heard from you, I anticipate
that
will
you
he in the States for the EEG meetings. I look forward
to seeing you in San Diego and, in View of your
extensive experience in EEG and psychiatry, I would
be delighted if you could Join us.
My best regards.
Sincerely yours,
Enclosed

follow—up

Max

Fink,

Even

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>May

1, 1969

Dr. R. P. Mbickel

Associate Professor of Pharmacology
Laboratory of Psychopharuacology
Indiana University
Psychology Building
Bloomington, Indiana #7401
Dear Dr. Maickel:
Thank you very ouch for your invitation to serve on the
Board of Consulting Editors for the Joulnal 06 Behavional
PhaAMacotogy. If I can be of any help in launching your

purpoaad new journal, I
Good

will be pleased.

luck.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFskp

�</text>
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wmmv—rv'l'v"

W

May

1, 1969

Dr. Marossa H. Orzcck
Boston University School of Hcdicine

Division of Psychiatry
80 East Concord Sttcet

Boston, Massachusetts 02118
Dear Dr. Orcack:

I look forward to caning you on the afternoon of May 21.
If that is unsatisfactory, MOnday, May 26. Please come to
my office at 5 East 102nd Street, 8th floor, room 42, at 2 pm.
call

If there is

my

any

difficulty with

secretary at (212)

any of these
369-7900 Ext. 245.

dates, please

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

MFskp

�</text>
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                    <text>F11!
u

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“"7
.

,

,

.,

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(212) 359-7900 Ext. 245

Mey

1, 1969

Dr. Sanghee Park
Wright Trailer Park

Rt.

A

Chapel

Hill, North Cerolina

27514

Dear Dr. Perk:

Dr. Freedman has been referred to me
please send me a copy of your curriculum
for reply.
vitae? 0n the occasion of your next visit to New York, please
Your

write

and

letter to

Would you

I will try to arrange

an

interview.

Sincerely yours,
Fink. MOD.
Professor of Psychiatry

M88

Hrzkp

cm?

m...

“$5”wa

W.

,

yawn",

unwww

prod-I'v—

�</text>
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                    <text>Kay

1. 1969

Dr. Ra Pa “nickel
Aaaoctaca Proton-or of Pharaacology
Laboratory of Payehopharuacology

Indiana Untvaraity
Paychology Building
Bloc-ington. Indiana 67401
Dear Dr. Haickalx

Thank you vary such for your invitation to aarva on the
Board of Con-ulting lditora for tha Jouanal 06 Behaulonal
9y. If I can ha of any halp in launching your

purpoaad nan journal,

1

will ba plaaaad.

Goad 193k.

Sincaraly youra,

“I! Pink,

Hana

Profaaaor of Psychiatry

Hrtkp

�</text>
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                    <text>..

uwn "w w

—'

wwvvz-

smwv

~

—--

1w

,mea-vv-

H'L-ﬁu‘s-Rﬁr:

-u.'1u—)Ir-» .|

vn-n“ mvmrwmzmmz-v-wwx wr-Wm K‘C,'&gt;~I!4‘_“

Dr.

um

Fritz Freyhan

New

York.

mus-news

5,

I

'W.‘"w1“"'l—'

Wam'\nv.

,

"rrww um.- a'wru—ruu-v

w evv war» '

‘Ilv‘

mea' 97"

1969

St. Vincent's Hospital
153 West 11th Street
Dear

New

York 10011

Fritz.

for the
suggestions are pencilled in
novel approaches or data.

My

The program format

APPA

and

is quite satisfactory.
reflect opinions as to

Robins probably presents a more general overview than

Ninokur.

For discussion of neurophysiology, both Perez-Reyes
relevant and novel data than Gershon.

and Bnyder have more

For an overview. Roth and possibly Dewhurst have more active
interests and relevant data than Grinker.
The meeting
My

place is shifted to the

New

York

Hilton.

best regards.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry
and Secretary

Max

xi."

—_.

ran

May

‘4’“

--v

'

Mszp

.ﬂ

,

,

�</text>
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                    <text>May

18, 1969

Dear Carl,

have no objection to the circulation to other ECDEU
invastigatoro of the demography data of our studies. Some weeks ago.
however, in anticipation of this meeting, I asked Dr. Simeon to
update the recorda of all our studies, and these revised forms were
cant to Dr. Guy. we would prefer to have the corrected listing
presented, if at all possible.
We

1

look forward to seeing you in June.

Sincerely yours,

Max

Fink, N.D.

Professor of Psychiatry

mf/

�</text>
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Mr. K. Skrlvanek

FROM:

Dr.

Max

DATE:

May

19, 1969

Fink

SUBJECT:
.v'.wu~w—

Nvm—‘V—m-W‘WI’WTIWW-"T

rm...

is wtfh greaf regref The? received a cepy of your
of
laffer
restgnaflon. Your associaflon with This Dtvislon since
your appointmenf Two years ago has been 3 mos? useful and pleasant
one for me, and The pafients and sfaff have beneflffed from your
in?eres+ and enfhuslasm.
IT

My

,.._

hes? wishes In your

of Mental Hyg!ene.

sum-W

w-v-Vrv‘vu,

I

MF:kp

new

poslflon wlfh

The Deparfmenf

�</text>
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“7v

4'

»-‘.rv~v-;“-.. ,_ Iu'w~4'-’r ——.W,. «a»... NN..n‘V»m..—-.r.,.wmmr—wmm‘...

TO:

Mr. Schwarfz

FROM:

Dr. Fink

v.3...wm-..

‘.‘.._.._.v..._

ﬁn.“ "w.“

”\wauwr ..

DATE:

..

V,

.,

n...

‘

.

.

May

m,

.. 7,...

19,

SUBJECT:

I.

concur in Ken Skrlvanak's recommendafions wITh
regard to fhe Division of PsychOpharmacology.
How

I

are fhese

+0 be implemented?

2. Can Tradeaoff an office af Mef for The one
usad 3+ £02nd Sfreef?
I

Mszp

Ken

,

IQCQ

�</text>
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                    <text>May

l9, i969

Mrs. Frances Nyberg

Assistant to the Director

American Medical Association
535 North Dearborn Street

Chicago,

lllinois 606l0

Dear Mrs. Nyborg:

Dr. Rosnick is a member of the staff and devotes 2/3
his time to our teaching and research programs. it is not
possible for us to insist that any member of the staff be
affiliated with any organization, and therefore hesitate to
give this message to him.

-

.

Please do whatever is consistent with your rules, including
and we will accept the outcome.

dellsting Dr. Rosnick,
‘Wﬂwm‘ﬁw‘vlwwmrQ1Wm4wm-‘J‘.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max
wr-Wm-

‘1

,

m

Mszp

�</text>
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                    <text>“‘1
WW

WW.

"W

May

l9, l968

Dr. w. Keup

Dlrecfor of Research
Brooklyn Sfafe Hosplfal

Research Faclllfy
68l Clarkson Avenue
Brooklyn, New York ll203
Dear Dr. Keup:
Thank you for your kind lnvlfaflon fo parTlclpafa ln fho
l969 annual meeflng of fhe EPRA. I would be pleased to review
The EEG effects of varlous halluclnogens, proposing a
classlflcaflon based on the central neurophyslology. An

approxlaale

flfle ls

"Neurophysiology of Halluclnogens

~

Sympathomlmeflc, Antichollnerglc and Oplalo", and wlll besf

ill

ln secflon Sb-c.

I

would Ilka

to propose the followlng partlclpanfs for

your conslderaflon:

I. Dr.

lfll:

3c,

3d

3. Dr. Arfhur Zaks: 39
4. Dr. Jan Volavka: lc
Thank you

for your lnvlfatoon.
Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MFskp

�</text>
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                    <text>Krm—w—tw.—

May

i9, i969

Miss Ellen Kaplan
E. R. Squibb &amp; Sons, Inc.
909 Third Avenue
New York, New York l0022
Dear Miss Kaplan:

in rereading This summary,

l

became concerned

lbs?

it

The Topics were covered in a haphazard manner, making
difficult for The reader. l have had fhe paragraphs re~

constifufed,
i

am

and

frusf fhaf This is heifer.

assuming you will add fha approprlafe references.

Am i corrocf in assuming also fhaf you will publlsh
tho compiefe reporf of our studies, submlifed under The
Title "Depot Fluphenazine in fho Treafmonf of Psychosis

in a Communify Menfal Health Clinic," by Luigi Bucci, M.D..
Marla Fuchs, M.D., Jovan Simeon, M.D. and Max Fink, M.D.?

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

enc .

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                    <text>any 19, 1969

Editor

Psychosomatico

Irvingtan,

Dear

ﬂew

Jeraay

Sir,

Enclosed are the carrcctad gallay proofs at our articlu
rgvtewing the alinical 3nd EEG effects of Doxapin. Tha dcl‘y in
their return insulted fro: my being nuly in Europe, und I trust that
tbs corrections may yet be undo.

Please revise aha 11:: of authors as indicated.

Sincltcly yours,

Fink. H.D.
Profeanot of Psychiatry

Max

mf/

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w

:w-—-

(IIIwrﬁwﬁm‘nmwvwvvldnwv—mraa

20, l969

TO:

A. M. Freedman, M.D.

FROM:

Mo

SUBJECT:

Collaborative Project with Dre. C. Miras and C. Stefanie,
University of Athens

DATE:

May

F‘i‘nk' MOD.

'Avgr‘I-WN‘W

mﬂ-‘wmwmwhwpfmwfuir-V'IVW-w-Ir

V‘r—-

w”

-———~w

-nw~w‘

Attached is my report of the facilities at the University of
Athens. These are ideal to answer certain important public health
problems.
Do Chronic marijuana users exhibit a syndrome of
organic mental changes related to this use?

Can a withdrawal

characteristics

What

state

be Induced?
in behavior and in

What
EEG?

are

its

are the physiologic and neurophysiologic
smoking in these subjects?

effects of marijuana

relationships can be defined, and
are these related to differences in response?

What dose

Assuming radioactive THC may be used in man,
what is its distribution and fate in human
tissues, compared to available animal Species?
in View of the active Public Health and Department of Justice interests
in marijuana, it may be appropriate to undertake a pilot study this
summer. Funding for a trial would include:

�.W

rwwhmw-WVWv-u-

-

W‘Plvr»

Dr. Freedman

~2—

Personnel

May

Supplies

U. S.

Psychiatrist

Greek

Psychiatrist

(SIBOOO/yr.)

5

20, i969

Salary

Travel

-

$I000

2,500

Maintenance
$

800

~

—

Laboratory Support
‘

Chemistry ($2000/mo)

$4000

-

—

-

(SiOOO/mo.)

52000

~

—

-

EEG

Travel: Additional for
2 American Supervisors

$2000

Volunteer fees

$l000

Telephong! cable

S

300

$7000

contract request

5

2500

$3000

S

800

be negotiated with the NINH (Dr. Yoiles);
and failing that, the Federal Bureau of Narcotics and Dangerous Drugs, the
Ford Foundation or the Foundation's Fund for Research in Psychiatry. Since
an NiM‘i contract is more likely, i would suggest we call first, then write
to Dr. Yoiios promptly.
Such a

may

This'hontract" is best presented separately from the proposed Kaéler-typo
application, although collaboration with Dr. eras should be included in that
application. This may present special problems and could best be handled
as a separate, concurrent application, possibly even one submitted through
the international Association for Psychiatric Research, which may be more
flexible in its fund management than the College.
Mszp

�</text>
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                    <text>May

22, l969

Dr. Nathan 8. Kline
Director of Research
Rockland State Hospital

Orangeburg,

New

York l0962

Deer Nate,
Thank you very much for referring Dr. Andermann
Karl worked with me at Hillside Hospital in i959-60.
I

found his work

reliable

to

me.

and useful insofar as we remained

in the category of descriptive encephalography.

Quantification
required the exercise of additional effort which he apparently,
at that time was unwilling to assert.

the ClNP met in Rome and we missed
The
dominated
sessions
were
by the basic scientists and
you.
at one point when the votes appeared to go consistently against
The Program Committee of

the clinicians (including myself) attempted to assert your
vote in addition to mine, but was turned down by the Chairman.
Part of the problem may have been the opportunity to induct
Alex Karczmar as a coworker in the Committee. The program that
I

finally unfolded is well balanced

and

i

think very good. There

will be a symposium on lithium as this seemed to be a most
important commonly accepted subject.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>. “.HV‘
..
mﬁ‘n—naqr'vr.-W’~Fthﬁ'—IIDJI\“"$WW

av.

. —.

-—er- mwm

~..: on;«Nu—(m. o. u- wv—I
,

.

May

22, 1969

Dr. Fink
Dapartuont of Pathology

Metropolitan Hospital
1901
Haw

First

York,

Avenue
York 1002.-

New

Dear Dr. Fink:

It is

obvious that no should get to know each other
I hava bean rocalving your calla and lettera,
I an aura you hora baau recalving mine. would you ploaaa
toll your oacratary that I can be roachad at 369-7900 Ext. 245
or 360-6746.
booauoa as

I

would

appraciata your calling

her where your calls can ha put.

my

aacrotary and telling

Sincaroly youra.
Fink, H.D.
Profaaaor of Psychiatry
Max

Mrskp

�</text>
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                    <text>May

23. 1969

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardaley, new York
Dear Edgar,
have an additional supply of 1m1pramine
for the ketimipramineeimipranine study. A label
is attached.
May

12 x 100

I please

Your daughter

is doing very well

important asset in our program.
Ky

and

is

becoming an

best regards.
Sincerely yours,
“83 Pink. ‘40”.
Professor of Psychiatry

Mszp

�</text>
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                    <text>;1

i
{E

I

my 23,

1969

Dr. Axel Rendrup

Sect

Hospital

Hans

4000 Roekilde

Denmark

Dear Dr. Rnndrup:

Enclosed is a cepy of the report of the symposium
"Experimental and Clinical EEG" in Liege. Would you

make any corrections or additions which you feel
necessary, and add relevant citations using the same

please

style that I did?
The

corrections

directly to:

and

citations should be sent

Dr. G. Verdeeux

Centre paychietrique Sainte-Anne
Laboratoire d’E.E.G.
1, rue Cabanis
75

Paris

France

I

was

very

and noradrenalin
I hope I quoted

14c

much impressed

with your theory of dopamine

sensitive syntems for the neuroleptice.
it correctly.

For many years I have been interested in the convulsive
therapy process. Some time ago I summarized the biochemical
evidence for cholinergic mechanisms and attempted to relate
the changes in EEG and behavior to the little biochemistry
that I could find in the literature. I am taking the liberty
of enclosing a copy of that report and would like to ask your
comments regarding the following questions from your experience:
In there any evidence for ECT for
any of the neurohumors similar to that
which you presented for the neuroleptics?

�t

11W‘V‘ﬁwt'quﬁWxI'awa-rr

Hum/m!

‘

'-

.-'—n.'.

-2-

Dr. Randrup

Can you recommend any

May

23, 1969

additional

workers or rcforonces regarding the cholinergic
nochonismo or other nourohunoral machinisns
which may be involvod in induced convulsions?
Do you have any theory of the
mochaninn of convulsions from a biochemical]

pharmacological point of View?

and hope
to continue our discussions
know
me
let
that when next you are in New York that you ofwill
associatos.
my
meat
scan
to
for
you
so that I can arrange
Many thanks for your participation in our seminar.

I

would

likc vary

much

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkp

�</text>
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                    <text>May

23, 1969

Dr. G. Verdeaux

Centre Psychiatrique Saints-Anne

Clinique de la Faculte de Medecins
Laboratoire D'electro-encephslogrsphie
1, Rue Cabanis

Paris

XIV, France

Dear Professor Verdeaux:

It

great pleasure working with you in Liege
pleased to enclose capies of the summary report.
Following your suggestion I have only added the references
from my laboratory which I think are important and trust
that the other participants will do the same. To expedite
the integration of the various comments, I am sending the
reports directly to Drs. Borenstein. Dongier, Itil, Longo,
Mellorio, Esquet, Pampiglione and Titeca and ask them to
send their comments to you as well as their recommended
and

I

was a

am

citations.
I have also sent a copy to Dr. Pure and Randrup
asking them to send their corrections to you.

Dr. Roubicek was very pleased when I told him of our
meeting, looks forward to your visit in September, and sends
you

his best regards.

Sincerely yours,
Fink,
m
Professor of Psychiatry
MOD.

Nszp

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