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                    <text>December 18, 1969
Dr. S. Venkat Ramani
1918

New

First

York,

Avenue

ﬂow York 10029

Dear Dr. Ramoni ,

for your application for a fellowship.
are unable to consider additional
appointments at this time, but will hold your letter in
I

Thank you

regret that

our

files,

we

pending a change in our programs.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>December 18, 1969

m.mwum.mwm

2727 Arizona Ave., Apt. 19

Yuma, Arizona 85364

Dear Mr. Chovan:

for your letter and suggestions. I regret
are unable to consider additional appointments at
this time, but will hold your letter in our files, pending
a change in our programs.

that

Thank you

we

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>December 18, 1968
Dr. Walter Modell

Department of Pharmacology
Cornell Univereity Hedicel College
1300 York Avenue
York, New York 10021

New

Deer Dr. Mbdell:

Enclosed is e drett;£gy, og'"Electrooncophnlogrene,
Mantel State and Peycholooiii’ rugs" for "Pharmacology
for Physiciene". I en most grateful to Dr. Hollistor and
yourself for your kind invitation, and for hie critique.

Sincerely yours,
Fink, M.D.
Profeeeot of Psychiatry
Hex

�</text>
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                    <text>.,

s

.

«n-

.
.1
~

-

n

'rw'ex‘r

a-Iv

mung-y

nu»

v.
.r‘

w
u
-

g

F

;

~

E

December 19, 1969
Dr. C. James Klett

Chief, Central NP Research Laboratory (151E)
VA Hospital
Perry Point, Maryland 21902
Dear Jim,
Thank you very much for the invitation to participate
in the Fifteenth Annual Conference in Houston in April 1970.
There are two aspects of our study programs that may be of
interest to the participants and abstracts are included for

your consideration.
My

best regards

and

best wishes for the

New

Year!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF

:kp

�</text>
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                    <text>Eecomber 12, 1969
Dr. Daniel P. Bobcat

Cliniqne Psychiatrique
University of Liege
Saint—Laurmnt, 58
8-4000 Liege, Belgium
Rue

Dear Dr. Bobon:

to your letter of December 14, the dates
satisfactory as any other during that
time. I am pleased that you are going to visit Professor
Itil. April is a beautiful time in St. Louis.
In response

April 13~25, are as

Sincerely yours,
armv’mmv

Max
0

ﬂF:kp

A
.

w
.m—

3151-!

(rm-3.3”

minim/11v

raw—IV!“

mum—Ivar”

I
mam,

v"W“’J!'V_’!“T"‘,"-r"!’

,

Fink, %.D.

Professor of Psychiatry

«myr'h’vjﬂ‘

�</text>
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                    <text>A.

.
,.

December 22, 1969

a
.A

y

~..,..-’.‘

rmvwnwun

Dr. Joyce Small

LaRue-Carter Hospital

Indianapolis, Indiana

nemmw;

W

—-vv'ww'"7

Dear Joyce,

Enclosed is a draft of the report read at the EAEEG. In
relating your observations to our own, I am aware of two problems.
Your data relates to the seizure and immediate post—seizure
activity; ours to 24 hours later. Whatever changes are induced
by repeated convulsions are more prominent in our sample than yours.
Assuming the accuracy of the observations, we can conclude either
an aspect of the immediate seizure state suppresses hemispheric
differences; or these are of such a clinical nature as to require
hours to emerge. I have been puzzled at the disinterest in MMECT,
and one possibility, from our experience, is that a chemical

aspect of the post seizure state is the therapeutic agent, and
this takes time to emerge, regardless of the number of seizures
at one time.
The September meeting was a

.A

Ma‘.‘

7'.

7;;

.:..w«r_-r(~o-,‘

an.

v-,~.~W:‘-na

success as

a meeting - good

discussion, interesting participants - but the group seemed too
heterogeneous to agree to meet again. The question was raised
of the advantages for such a group being formed, and when I
suggested that fund raising for travel, meeting rooms, guests,
etc. are feasible by a group and not an individual, there was
a unanimous authorization to form a "group". The World Congress
of Psychiatry in Mexico City was suggested as the meeting site.
I wrote to the secretary and have been told that an official
membership, as a section, is impossible; but an associated

meeting is possible.

If

I have

See you

in

the will,

I may

write again to

all

our friends.

Aspen.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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              <elementText elementTextId="40823">
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                <elementTextContainer>
                  <elementText elementTextId="103125">
                    <text>”A

.

"hm

:z'wrru,....-r.

December 22, 1969

4r

Dear A1,
-.

'WF’VM;'\

‘Y’Mi‘

com

v-vanhgrgwmmw

Don Klein of Hillside has asked if he could have
urine samples from our chronic marijuana subjects since

his chemist is trying to develop tests for
objection and Arthur sees no problem.
Any

THC.

reason not to cooperate?

.

Max

Fink, M.D.

I saw no

�</text>
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                <text>Correspondence to: ?, Alan</text>
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                    <text>,
o

.
.y

.
an.

A.

‘

..

.

"wwwuw

w,

w-..

.—.—....,

ﬂaw—w

WE‘un—“v

waaﬁ‘u‘ﬂ'

December 22, 1969

row

n"

'(yvvnm'v

'fﬁﬁmwi‘w

Dr. Donald Klein

ﬁillsido Hospital

P. O. Box 38
Glen Oaks, New York

Eear Don,

note to Dr. Essmen about urine collections seems fine, and I
have sent it on to Arthur Zeke who will contact you.
The

to Martin Green about the Indoklon-EEG records
to look at what may be available in
the records. If available, I'd like to send someone with him to
review the data.
I have spoken

wrn‘

m:

Mann-mun

at Hillside,
M'

Him

and he agreed

best wishes for a successful

1970!

arr-mum»

Sincerely yours,
rev-rm

“nu:

,r.
-

Fink, M.D.
Professor of Psychiatry

Max

mtg--

”Marv.

m-

;

Mszp

�</text>
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                    <text>J.ls-

.
«w:

1:»

r.Am-

’20-“

av

December 22, 1969
Dr. Thran

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

Enclosed

paper, part 1.

is a

copy of the

galley for our cycloserino

I have ordered 400 reprints, to give you 200 for your
use.
you wish more, please advise me and I will change

if

,;

the quantity.

'31»?

—\

My

best wishes for a successful

1970.

-,-w"-mya;7:&gt;

Sincerely yours,

v

-—

=

-.
V
&lt;-

'-

Fink, M.0.
Professor of Psyhhiatry

Max
agmrtwvrwnzzvrr-lvxw't7r."

Mszp
"'1

:}Q,§m'tm&gt;.-J«A¥a,wc;‘qn

-

1

‘

{VF-'3‘...

»

~'

m

«HM

'1'

~a1~qmm3¢mmvw

�</text>
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                    <text>December 22, 1969
Dr; Joseph G. Bird

Director of Experimental Medicine
Sterling-Winthrop Research Institute

90 Park Avenue

New

York,

New

York 10016

Dear Joe,
As a follow~up on your letter of December 4, enclosed
are the case records, dates of discontinuation and other

corrections requested.

Laboratory data on ambulatory patients

unsystomatic and unavailable.
My

best regards for the

New

is wholly

Your!

Sincerely yours,
g
:t‘wv

Fink, MD
Professor of Psychiatry

Max

17.1.

«.mwmmnmumrw-nvm-npwzw

MF:kp

�</text>
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                  <elementText elementTextId="103121">
                    <text>December 20. 1968
Dr 9

“on

Franklin

“at“
Roouevclt Hospital

D.

Honttoae, Rev tbrk
Dan: Dr. Knekow.

Br. Roubteak and I with to thank you for the splendid
intereating visit that we had last wmak. I hava also
received the notes you sent and have read thaae before sending than

welcoma and

on to Dr. Yraeéman.

for taxaarch at your haspital art indeed
I will encourage Dr. Frﬁeﬂman ta establish the relationship
ahich will parmit mambers mi this staff to participat$ 1n the
apocial programs which the VA has astablsshed. In raading the
vaports. I was most intareﬁtqd that half the patients were unéer
Mb yum-'3 of age and that. 0f these, half remaineé less than two weeks.
tuggasting that the population is mare acute than wag initially rapt.»
vented.
bright
‘

an&amp;

The apportunity

Again, our thanks for your euthuaiasm and I truat Dr.
Praodaan and uh: staff hare will have an occasion to discuss thin
Vitit soon.

linceraly yours,
Fink, .5.
Professor of Paychiatty

Max

112'

�December 15, 1968
To: Dr. A. M. Freedman, Chairman
From:

Max

Subject:

Fink, M.D.

Visit to

VA

Hospital, Montrose, December 11,

1968

At your suggestion, I visited Montrose VA and was
receved enthusiastically by the Director, Dr. Rackow. Dr. Roubicek
accompanied me on the visit. We met two of his associates and visited the
research facilities in experimental psychology and chemistry, and
the projected space for additional research programs. Dr. Rackow was

most

enthusiastic, cordial

and cooperative.

hospital is at least 1 hour from our present facility.
It is a typical chronic care institution with the majority patients
in residence for more than a decade. Schizophrenia is the principal
diagnosis, but alcoholism, brain damage and psychopathy are frequent.
Depressive states are rare.
The

1

Dr. Rackow has no resident physrﬁcians and is unhappy with
the present Dean's Committee which has emphasized committments elesewhere
in preference to his institution. He asks that a research and/or training
relationship be established, and anticipating the move to Westchester

asks

if it

could be done now.

Advantages: The VA has funds and has shown a flexibility in
other centers that is greater than other chronic care institutions. THe
center can provide funds, space and chronic mentally ill for a large
scale research and training situation, especially in research methodology.
Dr. Rackow

is enthusiastic

and cooperative.

Disadvantages: Distance from the present site is the
principal drawback. All the advantages of the VA center can be
provided by Manhattan State Hospital, if the Director of that
hospital could be convinced of the merit of cooperating as Dr.
Rackow sees it.
Employees recommended to the VA would have to sign loyalty
and
non—citizens are not permitted on the preserve in any
oaths,

official capacity.

Recommendations:
If an American

citizen of high academic stature could be
found, interested in developing the research or teaching program,
the opportunity would be of importance as both a source of salary
supplementation of senior staff, of patient populations for research,
and of much needed laboratory space.

The same could be develOped more cheaply, with less
travel restrictions, and with less dependence on citizenship, in
the state services. If we need such a facility (and we do) I would
urge another effort at developing the relationship at Manhattan

�State Hospital; and

Rackow.

for

VA

if that fails, reconsider discussions with

Dr.

(Note: Dr. Rackow will need a proposal and candidates
funds by early Spring for funding in 1969—1970)

(Note 2: Dr. H. C. Denber has volunteered to allow the
of
his ward for the students and residents, and would consider
use
-expanding his facility under your auspices. This solution would
not allow for our staff to write orders and treat patients directly

unless Dr.

Diamond

agrees Specifically).

Max

Fink,

M.D.

�</text>
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                    <text>«wunmﬁww‘

“ma-u...- . ....- ‘i‘I‘W-/:I&gt;

.

w.

.7

u

.V-

..

.

‘w—u.

mm --

,;s\»H-vr.

«any-u 0—"

an.

-, "runw‘ww—wy'w.“.urr.

‘vh‘v‘ v.~.-.-._.V.,_..——

‘,

.

1. pm 1 “w

w.- v

.-

uuﬁw—v—wm.”

r...»-

7-. v. .m-J---1

wr-

an... up...

December 29, 1969
Mr. Arnold Canter
Andrew Stuart Associates
Anderson Hill Road

Purchase,

New

York

Dear Arnold,
Would it be possible to provide coverage for the
aosistant secretary of the International Asaociation, Miss Kathleen
Pelczynski, 255 West 85 Street, New York City (Penthouse Front, 5th floor)

for the following items which she received as gifts this month
Diamond

,i’

/

ring(s)

$

Fur jacket

‘VA

The

statements are enclosed.
Many

5%

900.
595.

thanks, and

my

best for

1970.

Sincerely yours,

’1

‘
a
w

.9,...,..._v

,

ww..«mv..—_

w
w

"men-www-

mum-L7

-.—..

mﬂlmv&lt;

yawn-Wm

1-3:,—

.
.:-v~

0.

human

v

"K'Ynuv

‘1‘

Max

Fink, Md).

?

.w

_

.u

a

�</text>
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                    <text>September 2, 1969
Mr.

Jerry

Sherman

Sales Representative
White Laboratories, Inc.
Kenilworth, New Jersey 07033
Dear Mr. Sherman:

kind enough to leave
I have had occasion
to give this to a physician for trial and would suggest
an additional supply for clinical use. Would you please
send me two 8 ounce bottles of Permatil concentrate?
Many months ago you were

a supply of Permatil concentrate.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>September 2, 1969
Dr. T.H. Bonainger
Naval Modical Research
Bethesda, Maryland

Institute

Dear Dr. Benzingcr,

I have read the two articles in the latest issuc of the JANA
describing the measurement of tomperatlre using tympanic thermometry
with great interest. The figure in the companion article, describing
the changes in temperature with anesthetics is particularly relevant
to our studies, which are devoted to measurement of changes in EEG
during the intravenous administration of psychoactive drugs.

articles indicate that tympanic thermometry is safe
figures, the measurements are made in minutes. I would
like to ask if the equipment is available commercially; and from whom.
The

and from the

Does the instrumentation allow for;measuremcnta of changes occurring
within 2-3 minutes 7

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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Dr. Carl C.

Pfeiffer

Jersey Neuro-Psychiatric Institute
Box 1000
Princeton, New Jersey
Dear Carl,
I regret there was an error on page four of
the pilot study report on 8/22/69. Please replace
page four with the one enclosed.
Sincerely yours,

New

Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>September 2, 1969
Dr. Allen P. Berger

Chas.

Pfizer

&amp;

Company

Groton, Connecticut
Dear Allen:

RE:

Thiothixene

—

Study

EEG

I have reviewed the studies of thiothixene oral
concentrate and capsules, undertaken between August 1
and August 23. Using the protocol dated 8/21/69, we

have completed 27 experiments.

variability in these experiments has
in part, occasioned by our failure to carry outhigh,
a
more complete preliminary study.
Enclosed is a revised protocol (III) dated 8/25/69,
The

which summarizes our initial experiences and
which is now operational.
This study

is running well

within six weeks.

isthe

and should be completed
.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

one

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                    <text>September 2, 1969
Dr. Philip A. Boyer,
Medical Director

Jr.

Marion Laboratories, Inc.
10236 Bunker Ridge Road
Kansas City, Missouri 6&amp;137

Dear Dr. Boyer:

I regret there was an error on page four of
the pilot study report on 8/22/69. Please replace
page four with the one enclosed.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>SoptoMbor 4, 1969
Dear Rocco,
Your lottor about the norijuana tapes orrivod during the
dunner hiatus, and I on writing to report on their status.
The original tapes were analyzed using a period analysis
While
tho couples ware short. tho records abound luffioicnt
program.
chougts to rclato to the drugs given. Howevar, tho variability was
greater than I would have expected for the types of drugs administered.

and son

I decided to undortoko

if

we

Tho

obtained tho

marijuana

and we were concerned

some

none

triol:

of

my own

or different affocto.

with similar dosages

trials in

that

we

our hunda also showed great variability
were obtaining placebo effects.

That is how the mortar ottod before the summer exodus.
I have looked at the data again, and in viow of some reoaut experiences
with othor drugs at throohold dosages. I have aekod for none r¢~runl
of your data. That may be available before I loavu for the EEG moorings.
I will tako what I have along with ma, trusting that you will ha in San
Diego.

If

I'll

be

at the

E1

Cortes moral from saturday to Friday.
don't cost to the moorings, 1'11

you come, call no. If you
reach you after I return.

Sincoroly yours,
Max

Fink, M.D.

�</text>
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                    <text>September 5, 1969
Dear Mickey,
Your letter to Kuthy was phared with me, and I am
sorry that Laucot did not feel tho way an did about ycur work.
ﬁr. Munro's afterthought is indeed a rccumncudutlon, for I helluva
1t cxpruosuu sumo doubts about his position.

Thorc arc two road: open to you.
You arc committed to writing a draft for
Blclogical Psychiatry.
That 13 implicit in the award, and it was the unusual combination
the launching of a new journal and my own impetucuuity that led toofthe
first notca being sent there, as well an a prize papcr. It is
possible to send this paper (Hypothesis) to niﬁlogiccl
Psychiatry.

by

now

redrafting the introduction
have.

and including

all the data that

you

Alturnctcly, you could publish the draft that Dr. hortic‘
holds (V:3~23) and resubmit the Hypothesis to Seymour Katy
for
the Journal of Psychiatric Research.

now

'

The

firut choice is the loan:

work and the most

direct, with
tho least replication in the press. The sec and allows for
better
cxpcoutu. but requires morn work on your port and permits the criticism

that you huvu published aha echo material twice. (The more work would
in re~dtc£tlug the hypothesio to a paper. since I don't believe
JPR publishes theories).
be

Were thcy

Reprints frcm Biological Psychiatry were not received.
ordered 7 You might write to the publisher for information.

My

best regards.
Sincerely yours.
Max

mf/

Fink, M.D.

?rc£csaor of Psychiatry

�</text>
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                    <text>septembet 5, 1969
Dear Doria,
Thonk You for the invitation to speak to the New York
Biochamiool Pharmacology Diocuooion Group on Octobor 28 at the
How York Acodemy of actuaton. I on ploaood and honored to accept.
and will uoo as my text, tho summary of our work that I am preparing
for your volume.
.

'

If I understand the tonne of the letter. I am to cover tho
cliniool oxporionces with the various antagonists, including
cycloaooino. onloxone and uothoddno; with sown reference to the
aifforontoo 1n nourophyoiology of thoso compounds; and aoggooting
thereby that the node of action of oath may bo quite different.
To doocribo the neurophysiology would require sumo reforenco to the
EEG pattern: of each of tho oompoundo both along and with heroin, and
the pattern: of heroin olono.
‘OK 7

The title can‘bo ono of your choice; porhaps,
Pharmacological Therapios of Opiate Dependence: A Rational Therapy 7
or, Io Opioto Antagonism out a Rationnl Approach to Thorapy of Dependence?
‘

The

ready 800 .

chapters are in the process of rodrnftiog and should be

Again,

.

my

thanks for thinking of me.
ﬁinooroly yours,

Fink, E.D.
Profaasor of Psychiatry

Max

�</text>
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                    <text>SeptumﬁhttS, 1969

r
A“

”‘7.

‘.

'Dear Alex,

gum-’31,,“

gw

"mug,—

I hava received tha 1nv1tat10n to the centennial
ﬁehuvior, and regret that I cannot
havn
I
attcnd.
already accaptnd lecture assignmants in Philadelphia
for the 2 and 3.

a,

sympo¢1am, Brain nnd Eumnn

-.v

”7-

y,”

,

'w,m

is excellent, and yau are to be congratulated
makt
in its otgsnitat1on. It will
an impattant volume 3nd I look
forward to reading tha pub11ahad lummarias when they appear.

‘13.

‘

“a

s—wrngy—w-«mr

Tha maeting program

Thank yen also

VVK-nlmy-n

.w

raw

.
_,.

for tha

copy of yaur

lettar regatding the

GIN? program.1 understand you: feelings, and I cancur with them.
The meeting 19 run by tha Council hawever, and that group did
not have the benefit of out discussiana. The chairman was too
weak to report them accurately; «van 1n the rump session in waahington.

Ccnfuning isuueu of geographia and national representation were

introduead 1n ﬂushington, and in an after: to maintain my cquanimity,
I did not agrau with aha gxoup, nor did I withdraw. when another
rump session was helé in L1ege, the name axtta ideas intercgded.

It

nct surprising. therefore. that geographia
considerationa interterad in Switzerland.
was

pilitics.

political

fin.

meeting. Can we get together
soon thereafter
York, or shall I make an excuse
you be in
and fly to,Ch1clso Y
woulé
I
lika to get slang with an ROI project.
My anaccinte, Dr. Richard Abrams, was a ca—worket of a psychiatrist
on your Itaff, Dr. DeV1to. Ha could still bu 1ntcrcsted in In ECT
Enough

,

of

and

? W111

ﬂaws a

New

projact.

My

best ragatdn.
Max

Fink, M.D.

�</text>
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              <elementText elementTextId="40668">
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                    <text>——m
_-

September 9, 1969
Mr. Barry L. Garter
25 West Flaglcr Street

Miami,

2.1",

.wwI'r‘w'y-"vr'nu-

4.

“a

u..-

mum-":1

7v-

Florida 33130

Dear Mr. Garbcr:

This

Michael Glass

RE:

is to advise

you

that Michael Glass of

275 Middlencck Road, Great Neck, was seen in
psychiatric consultation. He was recommended

for

psychiatric therapy with Dr. Gould. Therapy is in
progress and it is inadvisable to interrupt treat~
ment for a period or at least two months.
Sincerely yours,

»

W’ng—‘VJVW'r—J

.

Vow“).

Max

Fink,

M.D.

Professor of Psychiatry

aw]...

Mszp
.‘r'ml-'I"‘YY"T!

-.w—v«

«M

"ﬁlm-r:

“ANN"!

,

bcc.

Dr. Walter Glass

‘r-

mum-rm—

�</text>
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                    <text>.

rsnwxwww

W»WWW","tau

v-vu—u-u-r,wwxm-m—wg—ww.

I’w' («warn-w.

r: m,W'a-‘was‘u-

.
..,

.-

.

.

w...”

._..

.
..

&lt;_

wwpwpw—e-

m-..

_.

September 9, l969
Dr.

Fritz

A. Freyhan

St. Vincent's Hospital
153 West

New

York,

Dear

llth Street
New

York

lOOll

Fritz,

Enclosed is our report "d-Cycloserine Therapy of Psychosis
for your consideration for Compaehenaiue
Psychiaxxy. This has not yet been edited by Dr. Itil. He plan
to go over this on Thursday and if there are any corrections these
can be made out within the next two weeks, if the report is

by Symptom Provocation“

acceptable.

also enclosing

interim report "Acute EEG Effects of
With the appropriate figures (which
are now at the artist) and some corrections in the text, this
could be prepared for publication by October l0.
I am

an

Heroin and Naloxone in Man".

After talking to you, I realized we have a third report
is being revised and may be of equal interest. This
confirmation of a paper written by Pitts and McClure in the
New Engzand Jamal: 05 Medicine may be of even more interest
to your readers.
which

_

Also enclosed are some notes from Dr. Donald Scott regarding
device for monitoring EEG in patients in coma. He is using
this in patients with cardiac arrest and it may interest you.

a

new

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mfzkp
EROS o

.u.

—

wrap-

W‘Adn-u

Inn-1"". N," V-.." nun-m—
.

�</text>
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                    <text>rum-er ‘1‘i.Imu-L':,"‘my"‘i"ﬁ1.uwr‘wf1“'fl|‘.o-~SrIIr-‘jr'‘

V

7

,

.

mar—T,"

cums. 4M.VW'|V:1”K\\-rrv:/r .r

.

,1"

,

“J,"

.

~1Hv"w¢mmwurwp“~ﬁ‘yvl-.—

t

“(Wyn——

‘

September 9. 1969
Dr. R. Peterson

National

Institute of

5454 Hisconsin

Chevy Chase.

Mental Health

haryland

Dear Bob.
I am writing with regard to a proposed grant - contract
to develop a delayed release implantable naioxone.

Following our original discussions with Dow~Corning.
the makers of silastic, we contacted the Food and Drug Research
Laboratories, Inc., as a local concern with experience in the
development of delayed release compounds. After an interchange
of letters and discussions they submitted a proposal dated
August 22. The program follows our request and we believe
that such a program has public health merit. Their budget.
however. is reasonable for direct costs, but unth the over—
head. appears larger than the contract amounts which were
discussed with Drs. Cohen and Miller in June.

are aware that NIMH is supporting a contract with
at the University of Delaware. Considering the
magnitude of the drug addiction problem and the logic of an
implantable antagonist, we would like very much to recommend
the additional program in New York. If an implantable naloxone
could be produced, we would like to do the clinical assays.
we

Dr. Yolles

I am

writing to ask the best route to obtain

of this request.

The

possibilities are

through the
l) Contract
HYHC
(With

2)

overhead?)

many

a review

including:

hen York Medical College.

Contract with an individual. Dr.
(no overhead).

A. M. Freedman

-

(4.

.

3) Grant application (as a grant

like to

we

would probably

this program to include our
for
clinica
trial as well.
expenses
expand

N'.~w=r‘v:g' ovum—m

,

q-

2”“; w w'm.w1

3:”

my

�Dr. Peterson

-2-

Septenbor 9, l969

Since we are not the primary contractor. what do we do

frist trial of

nine months is unsuccessful?

I would be

reached

at (212)

grateful for your recomndations
or 369-8488.

369-7900 Ext. 246

Max Fink. NJ).
Professor of Psychiatry

GHC.

the

and can be

Sincerely yours .

MF:kp

if

�</text>
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                    <text>September 9, 1969
Mr. Barry L. Barber
25 West Flagler Street

Miami,

Florida 33130

Dear Mr. Garber:

This

RE:

is to advise

you

psychiatric

therapy with Dr. Gould.

Therapy

for

is in

progress and it is inadvisable to interrupt treatfor a period of at least two months.
Sincerely yours,

ment

Max

Fink,

M.D.

Professor of Psychiatry
Mszp

"1||v‘-yv‘"~'"“

pr

that Michael Glass of

275 Middlcneck Road, Great Neck, was seen in
psychiatric consultation. He was recommended

w‘ln‘Ar

"rmv-avv—

Michael Glass

bcc.

Dr. Walter Glass

�</text>
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                    <text>J
.
_
.

_

H

A,“

1..“

"nu—WWW

”M

,.

,
A'oww

Warm...”

September

l0, l969

Dr. Hilliam Tabor
A. H. Robins Company

l407 Cummings Drive
Richmond 20, Virginia
RE:

Dear 3111,

Please
follows.

amend our

AHR-l900

protocol for the study of

will be increased to 200 mg daily,
maintained for periods up to four weeks.
Dosage

AHR-lQOO

as

and will be

rate of administration of medication will be daily
increments of lo mg for three days. 20 mg for three days
and 40 mg a day thereafter (a possible schedule is l0 ~ 20 200).
lOO - l40 - l80
30 - 40 ~ 60 - 80
The

—

—

he have observed no changes in blood pressure which
would make us hesitate on such a rapid increase.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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                    <text>September 17, 1968

Librarian

New York Academy of
2 East 103rd Street
New York, New York

Medicine

Dear Madam:
would be grateful if you would permit Dr. Richard Abrams
to work in the library during the hours open to Fellows as he
is working on a project for me.
{gﬁL7‘€3£39§xxR

I

I

If he finds it necessary to take out

would approve

his doing so.

books and

Sincerely yours,
.
.-.~.

rnmn

Fink, M.D.
Professor of Psychiatry

Max

mun-wrung"

u
'W

ml.

:14

..
rr.

wwnrma

;.s.

WWW-

1””

.

_—.u a, . ,

journals,

�</text>
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;

.

r

September 18, 1969
Dr. Kenneth

Lifshitz

Research Center

Rockland State Hospital
Orangeburg, New York
Dear Ken,

glad to send the reprint you request,
but I don't get Pszchiatrz. Please have your
Would be

secretary check your f1
Journal.

e and send

the

Thanks.

title

or

-W

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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'13—'gr:IRI.-.a
. ..,M‘;,....w—,..-.n.,N..5....-,..;»p-ww...“-

\—

n.

p«:.-.w,.:.._v. ,

,w

.

,,

.

a-..

,w.

.

.

,,

w

a. ”r...

w

a,

Maw/y

'rI!IlR~raH-v'\‘x-

September 18, 1969

Professor Robert Werman
University
Department of Zoology
Jerusalem, Israel

The Hebrew

Dear Dr. Werman:
Your name reminds

who was

me

of a friend from

working in Indiana.

the same Bob Werman?
If so, my best regards.
Sincerely yours,

Are you

Max

Fink,

MD

Professor of Psychiatry

mf;kp
enc .

New

York

u

.

.,...,,.

a

w... T,

www.mm-

«'1,

-

”gamer

n.0,. .w,..._. u.
.

.v—

w

�</text>
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                    <text>ﬁeptcmber 20, 1969
M. Clark
School of Public Health

Mrs. Korean
CU

New

York City

Bast ﬁrs. Clark,
Thank you for your invitation to participate in the
caurue in Public Eealth on October 22. I ragret that I am unable to
participate, as i plan to attend a conieranca in Califarnia during

that

week.

May

I auggeat that either of

staff may be both able and willing to
suggest you write to them directly.
Dr. Arthur

M.

Dr. Richard Resnick, H.D.,

Thank you

at

my

other

participate,

23kg, M.D.,

Both may be reached

two

members

of

and I would

Instructor in Psychiatry
Assistant Profenaor
address.

agtin.
Sine-rely yours,
Mu: Fink, M.D.

Professor of Psychiatry

mf/

my

�</text>
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                    <text>Septanbar 22, 1969
Dr. Holmnt Laehnat
Barbiaon Plaza ﬂotal
Dear Ralmut,

It will be a pleasure to have you visit my laboratoriaa
during your forthcoming v1.1: to Nav York. Plaasa call my attic.
after you arrive and I will plan tha beat schodula for you.
212~369~7900,
SIG-£66~3158

Fifth

ext.

at 5 gas: 102 Street, cornat of
floor, Econ 42.

Hy

laboratory

H7

beat regards.

Avanua; on the 8th

245. 246 ~ officﬂ
* honn

1a

Sincerely yours.
”lax Fink, M.D.

Proteaao: of Paychiatry

all

�</text>
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                    <text>September 22, 1969
Dr. Cay Waller
Professax of Pharmacy

Univarsity of Mississippi
ﬁniversicy, Misaiiaaippi
Dear Dr. Waller,

It was a pleaeure :0 have you visit-our leborathries last
week, and your discussion of tha varieties of marijuana and the difference:
in TEC content was most inawructive. Thank you.
I would lika to aak your cooperation in annaying the
which
I imparted from Athens in May. Enclanad is a sample as
ha$hish
suppliad by Br. Konstantin Miraa, and another as procen:ed by hta during
a visit to our laboratories. he dry pvwder 1a the matarial as received;
the brown reaidue as reanlting from a slow haating using a heating
iron in our laboratory. The heat was applied slowly and uniformly for
approximately 10 minutes to a sample of the gowder encasad in a dry
paper and Rap: wet with water during the heating precess.

analyoia of the two samples should yield the same
content. It would ha important to know,_haw¢var, what changes are
introduced by this form of processing, as recommended by Dr. Miran. (He
reports that th¢s processing 13 the favored one in Athens).
An

THC

Thank you

for your assistance.

My

hast personal regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                  <elementText elementTextId="103099">
                    <text>September 22, 1969
Dr. William P. Wilson

Department of Psychiatry
Duke University
Durham, N.C.

Dear

I

E

k

Bill,

I very much enjoyed chatting with you in San Diego.
Since I was unable to attend your presentation of the Haar function
for automatic EEG analysis, I am writing to request a preprint copy

if

one

is available.
Many

thanks.
Sincerely yours,
Max

mf/

Fink, NJ).

�</text>
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                    <text>.39.

MM
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Etch? 36
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Egilegsz.Abstracts.
Please send

me

back issues of Egilegsx

Please send

me

back issues of Egilegsy

Abstracts, Vol.

I. (if available)

Abstracts, Vol. 11.

Name

Address

_w_

Organization __

�v
w

up,

r
-

.-

v-VIIW»-.~zarln4.

---.

September 22, 1969
Dr.

J. Kiffin Perry

KINDS, HIE

Bethesda, Haryland

Dear Dr. Perry,

anr exhibit of a citation and abstract search for
epilepsy abatraota at the International EEG meetings in San Diego
was moat intereating. The aearoh worked well and the available
data base will be neat useful.
Some yearn ago, at the Hiaeouri Institute of Paychiatry,
aaeociatee and I developed a aieilar ayaten for the IBM 1710 for the
apecific aubjecta of EEG and Huean Psychopharamoology. we elected to
one citationa and uniterma, and after one year's experience found that
the abatract or auenary wee preferable to the unitere or the QWIC
index nethoda. Funds, however, were not available, and we abandoned
the project.

my

exciting.

make nee

The

and the data base it most
what conditiona we may

availability of your system

I an writing to enquire under

of the system.

we

have an

IBM

360/AO

at the College with

terninala as well as aome apecialized acope terminals.
computer center in dedicated to the servicing of the profesaionnle of

the usual

Our

and

13M

the College, including the Departmenta of Neurology and Paychiatry—for when your data bane may be useful. In there any provision for
our application for the use of your ayatem 2

In there any provision for the extension of your data baae
to include other abstracts of NIH, such as Paychepharmacology Abstracts
of NINE 2
Thank you

for your cooperation,

the success of your project.

and our

best wishes for

Sincerely youra.
Max

Fink, M.D.

Professor of Psychiatry

of]

Chairman, Computer Counittee

�</text>
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                    <text>September 2”, 1969

...

“KW”,

my",

n

A
.

-7

Dr. F. A. Freyhan
Department of Psychiatry

St. Vincent's Hospital
153 West 11th Street
New

York,

Dear

New

York 10011

Fritz,

Attached are some notes regarding the

ACNP

symposium
would suggest

I
training in clinical psychopharmacology.
some simple
answer
to
number
centers
of
of
a
a telephone survey
psychoinstruction in clinical
questions regarding the typeandof residency
The
principal
levels.
pharm at the undergraduate
how
any,
if
texts,
often,
who
teaching,
does
the
question is

on

and format.

Copies of my notes are attached and these may form the
basis for an outline which can be used for a telephone survey.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFtkp

enc .

�CLINICAL PSYCHOPHARMACOLOGY

SURVEY

Undergraduate
New York

NYU

Columbia U
New York Med. Col.

Albert Einstein
Cornell

-

Jersey
Philadelphia
New

Durham, N.C.

Boston

Rutgers
Temple

Penn.
Duke

Howard

BOU.
New

Haven

Baltimore

Yale
Hopkins

-

Minneapolis
San Francisco

Minnesota

Houston

Baylor

Langley Porter

Stanford

Residency

/
/ (P.I.)
/
I
/

Hillside

?Analytic

/
/
/
/
/
/
/
/

Instit.

Menninger
Univ. Minn. Postgrad.

/
/
/

�A.

B.

How

is it taught?

l.

Lectures -

2.

Care Conferences?

3.

Role of Detail

Topics Covered

How many?

Who

gives?

men

—

Chemistry
Pharmacology

Animals

Physiology

Man

Neurophysiology

Pharmacy

Toxicology

Indications

—

clin. psychiat.

Management problems

1.

Selection

2.

Dosage Schedule

3.

Toxicity corrections
Combinations (synerg., antagon.)

1;

.

Rel. to clin. psychiat. - part or separate
h.

Literature

1‘.

Experimental studies

&amp;

history

J. Textbook
k.

Attendance - elective or compulsory?

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                    <text>September 2h, 1969
Dr. Edward Woodward,

A. H. Robins Company
1&amp;0? Cummings Drive

Richmond,

Jr.

Virginia 23220

Dear Dr. Woodward:
The

effects of fenfluramine, amobarbital
in its entirety.
has been described in the following reports:

report of

EEG

and dextroamphetamine has not been published

In part,

it

Electroencephalography, Mental State and
Psychoactive Drugs, in Pharmacolo for
Physicians, W. B. Saunders, Phil., 3255: 1-5, 1969.

Patterns as an Index of Clinical Activity
of Psychoactive Drugs. Electroenceph. clin.

EEG

_,«

-,

7-wa‘:‘;u§d'v

mag-n

V._.,_._....&lt;

WW.

(abstract) 1969.
A complete repott is being typed for submission to the EEG Journal.
The fenfluramine - reaction time data has been reported at
various meetings by Dr. Itil but, as yet, has not been published.
Neurophysiol., 27:

710

Sincerely yours,

:w/ﬂ-anw—«wvw'x

-

*anw'b

Max

4

-

,/

Fink, M.D.

Professor of Psychiatry

wr&lt;rv=fuu77

MF:kp

enc .

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                    <text>September 29k 1969
Dr. William Tabor
A. H. Robins
1H0? Cummings

Richmond,
Dear

Virginia

Bill,

like to revise the protocol for the
study. We have failed to see behavioral
EEG
effects at the dosages up to 200 mg/day for
or
10-1h-days. For the next few subjects we will increase
We

ARR-1900

would

the daily dosages to ROD mg a day.
In order to accomplish this, may we have an
additional supply of AHR~1900, 30 x 50 x 10 mg?
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF : kp

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                    <text>September 29, 1969
Dr. Jerome Levine
Psychopharmacology Research Branch
National Institutes of Mental Health
Sash Wisconsin
Chevy Chase, Maryland
Dear Dr. Levine:

RE:

MH—13358-03

With reference to MH~13358~03, may we request
the reallocation of $2,000 from "Personnel" to the
category of "Outpatient Costs". As we described to
you during your recent visit, we are increasing the
number of volunteers receiving drugs in our EEG
study program. This will increase the allocation
for outpatient costs to $5,000 and reduce personnel
to $132,060.
Thank you for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

BY:

(Mrs.) Lorraine Lasker

Director

Research Administration

Mszp

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                    <text>September 29, 1969

Professor George 0dian
Chairman, Division of Science and Engineering

Richmond College,
130

CUNY

Stuyvesant Place

Staten Island, New York 10301
Dear Professor Odian:
I am writing in response to your query (9/16/69)
about Professor Joseph Schwartz.
Professor Schwartz was with us during 1967 and
1968 as a project leader on a study of the modeling
of electroencephalographic responses to psychotropic
drugs. He developed a physical model of the EEG response
to pentothal, and completed an important report now
being considered for publication. His contribution
represents a significant addition to the body of
theories and methodologies of electroencephalography.
The scope of Professor Schwartz's formal training
as
you must know, unusually wide, covering as it
is,
does the physical, biological and social sciences. His
research, which spans these diverse areas and may be
described as truly interdisciplinary, is of unquestionably
high quality.

Dr. Schwartz was a

of our team and
In

short, I

we

am

and would continue

reliable

and

enthusiastic

miss his enthusiasm.

certain that Professor Schwartz is,
member

to be, a valuable
Sincerely yours,
Max

Fink,

M.D.

of your Division.

Professor of Psychiatry

MF:kp

member

�</text>
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                    <text>Septombor 29, 1969
Dear Doris,

that tho word "EEG" be included in the
discussion
at the Biochemical Pharmacology
title of the forthcoming
re~rood
Discusoion Group, led no to
your lettot. If the focus is
to be on 'ourront thoropy programs involving the one of ogontoto
and antagonists', than the EEG in peripheral, for in our hands it
is a research index only. The new douse have been dofinod by other
means. and in our clinical testing, the EEG 13 tho indox upon‘whioh
we put some rolianoo, but other: havo not accepted our Viewo.
I will discuss the EEG data, and yet helluva you would profor a clinical
discussion. For this reason, I omitted EEG in the title. A compromise
may be:
Your roquoat

-

Drug Tﬂernpies

of Opiato Dopendonce:01in1col and
Assay Methods of Efficacy

EEG

In addition tO‘thO usual mailing list. would you send on
announcement to Dr. Joneph Bitd (Sterling~w1nthrop). Ralph Jaooboon
(Endo), Henry Brill and ﬁarold moioolos (HYSHACC); and another
half dozoo to me, so that I can send them to some others who may be

interested.
sooner.

Hy

I look forward to seeing

boot regards.

you

at the

meeting,

if

not

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/
Dr. Doris Clouet

Research Institute for Nouroohemiotry
Ward's Island
NYE

How

York City

.

�</text>
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                    <text>.....

September 29, 1969

Dr. G. Verdeeux

68 Rue de Grenelle,

Paris, France

vii

Deer Georg,
We

symposium

missed you, both in San Diego and in our little
in New York. The meetings in San Diego were very

fine, particularly the sessions celebrating the anniversary

of Berger.

The

sessions on psychiatry were dominated by the

fine presentations of Dongier and Small. The sessions on
drug therapies were done poorly and you were missed, for
your substitute had no experience and little knowledge
(K.

Killam).

Our session was attended by 24 and the discussion
was very animated. There was much disseneion about the

role of

EEG

in psychiatry, but

effects were discussed, there

when

the data about drug

was good agreement. I am
about the meeting and will send you a

preparing a report
copy when it is ready.

Pep Panpiglione and V. Longo attended. They
indicated that the summary of the Liege meeting had been
completed and they seemed to recall receiving a version
of the report from you, after the summary (preliminary)
which I had prepared had been received.

Is the final summary of the Liege symposium
completed ? If so, I weuld appreciate the opportunity
to review it before it is finally published-~ if that
is 81111 possible. Has Professor Bobon accepted the
material for publication in a journal ? which ?

I

hope to have the honor and opportunity to

continue our discussions soon. The Berger Society may yet
be born, and perhaps we will have the pleasure of
discussing our interests then, or at a sooner date.

Professor Roubicek also attended the sessions in San
Diego and New York, and expresses his best regards, and
trusts that it was not ill health that prevented this trip.
He is planning to visit his family in Munich next month and
be able to call on you, en route.
my

best personal regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

may

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                    <text>,.. ‘— .,.. NV", . ‘.__r.n—.r—m-

October 3, 1969
Dr. Charles Weller
17 North Chatsworth Avenue
Larchmont, New York 10538
Dear Charles,

for a data base for a €088 for psychiatric
diagnosis is great, and our discussions have clarified my
thinking to a degree that I believe we may be able to
undertake this mission. My present programs already include
the development of an interactive diagnostic system for
psychopharmacology research using some of the established
rating scales (Brief Psychiatric Rating Scale, Hamilton
Depression Scale, Spitzer Diagno II).
The need

this program toward
a competent programmer
I believe it could be done in 12-18
position, I would like to recommend
who have worked with me and who now
To

broaden

will require

the

SDSS

data base,

we

and a young psychiatrist.
months. For the latter
either of two young men

are in the military.

Drs. Robert Levine and Michael Taylor, as

year
residents (1968-69) were most productive. Theirthird
independent
investigation on sex ratios and schizophrenia was so striking,
it was awarded the 1969 prize of the
New York
Society at the Academy of Medicine in March andNeurological
the Clinical

Science Research Award of the Society of Biological
Psychiatry
in May.

heartily

They are outstanding young clinicians, and I would
recommend them for this mission.

Dr. Levine

is stationed at

Force Base, Texas 79607.

228 Texas

Drive, Dyess Air

‘-

9309

Dr. Taylor is stationed at Oakland Naval Hospital,
Murillo Avenue, Oakland, California 94605.

will

Dr. Freedman, the Chairman»of the Department of
Psychiatry
endorse their reappointment to our Department, and
I look

“1.,

r,

._.

.

kyrve,“

forward to your recommendation.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>October 3, 1969
Br. Ronalé C. Kersh
Research Assistant
Department of Mental Hygiene

Metropolitan State Hospital
11400 Norwalk Blvd.
Norwalk, California 90650

Dear Hr. Kersh:
The

Stratton

Award

of the

American Psychopathological

Association is an annual determination by the Council of the
Association, honoring those active in research in psychOpathology.
The award is given each year on the occasion of the annual meeting.
The next meeting will beoon February 13~l4, 1970, at the New York
Hilton and the subject is "Disorders of Mood and Affect".
Non~members are welcome at a $2.00 registration fee.
Sincerely yours,
Fink,
Secretary

Max

HF :kp

M.D.

�</text>
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                    <text>October 6, 1969
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
The enclosod

version of "§7Cycloserino Therapy of Psychosis

by Symptom Provocation” was sent to Fritz Froyhan for publication.
lo accepted most of your suggestions - and would be delighted
to see a more detailed EEG blood level analysis. Jovan will send
you the available data.
I have also sent a copy

to Ivan Bennett.
Sincerely yours,
2"an

Fink ,

M. D I

Professor of Psychiatry

an: :kp

�</text>
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                    <text>October 3, 1969
Dr. Jose R. Lombillo, Director
County Mental Health Clinic, Inc.
P. 0. Box 1302

Collier

Naples, Florida 33940
Dear Dr. Lombillo:

Membership in the American Psychopathological Association
be recommendation by members of the Association. May I
suggest that you look through a recent volume of the
of the Association, published by Grune and Stratton. Proceedings
The annual
volumes contain a list of active members and you should feel
free to contact any of them for a recommendation.

is

The next meeting of the Association will be on
February 13, 14
New York Hilton and the
subject is ”Disorders of Mood and
Affect”. Non-members are welcome at a $2.00 registration fee.

at the

Sincerely yours,
Max

Fink,

Secretary

M.D.

�</text>
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                    <text>‘SV'vv-wavw.

w. wu—
—

‘1'".xw7m.17,m,w~~ﬂs—urrww-.,,~,.__

..V

1...“

m."-

n ruv

5".‘vml'ww

October 6, 1969
Dr. Ivan Bennett

Lilly Research Laboratories
Eli Lilly and Company
Indianapolis, Indiana 46206

The

Dear Ivan,

After many years, we have been prompted to comylete
the enclosed report, ”§;Cycloserine Therapy of Psychosis
by Symptom Provocation” and it has been accepted by Fritz
Freyhan for Compaeheneive Psychiatng.
In reviewing this data, we were once again impressed
in large doses, has useful CNS activity Seromycin,
that
useful as a stimulant for depressive and withdrawn subjects,

particularly those in state hospitals. Perhaps, further
studies

can be stimulated.

Thank you

for the Supplies.
Sincerely yours,
i'iax Fink,

f‘goDI

Professor of Psychiatry

MF:kp

cc:

T.

Itil

.-». -,

n nmswrw—wr—

,

a.”

�</text>
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                    <text>n-nr-mwrmmw'mw'm'l' {Wm-

rut-s

.

'r'. .7.

»

.«V-"wm-x-«w-uw.“—._ .- 47...... 'uvuAHMTM “my—any“ «pm-pu-

0.

,-

v
-

.—

A.-.A

mirr‘xruva-w—U'T-vw'

October 6, 1969

.«

wﬂpvm—wm.

.r
,

.—¢-w&gt;‘-—K"-u"rwmr'fv

Dr. Max Holfand

65

New

Central Park
York,

New

West
York

Dear Max,

is a collection of reprints of studies completed
the
during
past many years. These are the basis for our present
study program in convulsive therapy. When you have had an
Opportunity to read thoso please call my office.
Enclosed

I would

appreciate your returning this.
Sincerely yours,
MEX

Fink 'MOD.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>«mm»

'Jrr-V‘

z—rr—rm

m"

v—-

-.rwrv:

17—.

mn.‘wm~.r

wv

_

n-

~

w-Wn—z

bnlw'm'rm-w'

mmrnfm—Eww.m ‘7va.-

October 6, 1969
Dr. Fritz A. Freyhan

St. Vincent's Hospital
153 west 11th Street

New

Bear

York,

Now

York 10011

Fritz.

Enclosed is a final draft of our rape:t “ﬁftycloserino
Tharapy of Psychosis by Symptom Provocation” for your

considcrntion for Compaehenaiva Paychtatay.

Should the other reports interest you, it will take more
editing to put them in reasonable condition for publication
(and more time).
my

best ragards.
Sincerely yaﬁrs.

Profhssor of Psychiatry
HF:kp

mu?

1m-..- -r Pp—swuvrv.

.

”.m—

�</text>
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                    <text>October 7, 1969
Dr. Allen P. Berger
Chas. Pfizer Co., Inc.
Groton, Connecticut 06340
Dear Allen,
CP

May I

please have

14368-1, 50

mg

each.

an

additional bottle of

100

are undertaking additional studies at the higher dosage
present supply will soon be exhausted.

We

and

my

Sincerely yours,
Fink, :‘IQDO
Professor of Psychiatry

Max

MF:kp

capsules

�</text>
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                    <text>ﬁw-W

Mr. Daniel North
Local 1199 News
709 Eighth Avonue
New York, New York 10036

0ctobcr 7,

1969

Dear Mr. North:
I regret that it is outside of our usual policies to
allow photographs of the treatment programs of this Department.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

.

war..—

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October 7, 1969
Dr. Walter Modell, Editor
Pharmacology and Therapeutics
Department of Pharmacology

Clinical

Cornell University Medical College
1300 York Avenue
York, New York 10021

New

Dear Dr. Modell:

inquire as to the status of the report "Clinical
Antidepressant Activity of Cyclazocine A Narcotic Antagoiist"
resubmitted on May 1, 1969.
May I

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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.,

mu—w—FW,

y.

~w——;-—v-_—.

“Wmmm—w—WW

1......“

WNWWW

-

October 7, 1969
Reeve Angel Co.

Clifton,

New

Jersey

Gentlemen:
We are
acting as correspondents for scientists
the
at
University of Athens who have requested that we obtain
supplies of "ion-exchange paper for the detection of drugs in urine"

on

their behalf.

I would appreciate a description of the supplies and
of
ion exchange papers.
costs
Thank you.

.Wy—rlwwva-WV'IV‘th‘

Sincerely yours,
m

4mm

w."

.1",

1WWv-wm-v"

7.

wvv‘m

W

-rwvw5'ﬂ'~

"(w-w

“W;

Max

Fink, M.D.

�</text>
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                    <text>v‘

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,

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~—

.

_

m‘Ev’InK-K’u‘v—J—wr'nv

wwwt

m--. ‘kuwi—u—

—-mu~.mv—xn~

October 8, 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals

Ardsley,

New

York

Dear Wilma,

Enclosed is our interim report and revised protocol in
our studies of GP-41299. Pages 1-8 are the same as the copies
which you have.
I have revised the clinical trial sections, following
your suggestions and after discussing the possibilities with
We do have a number of patients who have been
my associaties.
maintained on either chlordiazepoxide or doxepin for many
months, and also some schizoPhrenics who have been maintained
on phenothiazines. These patients can be placed on placebo.
In the event that symptoms recur, we will be able to begin with
GP-41299. We will have to determine the dosage first and if
an effective range is observed, I would then plan to treat
alternate patients with chlordiazepoxide or GP-41299.

Concurrently, I plan to select a few patients admitted
for severe anxiety or schizophrenia to our in—patient beds and
begin Open clinical trial. In these the possibility that they
are resistant will remain.
laboratory data will be insured in the in—patients
do our best in the out-patients. You are aware
that it is often difficult to obtain the cooperation of out—
patients for laboratory studies.
and we

The

will

Part two of the EEG trial (GP vs. placebo) will begin
within the next few weeks. The clinical studies can begin
early in November and for this I request a supply of 25 mg
capsules of GP-41299. If available, 1000. It would be helpful
to have 200 additional placebo capsules.
nr' Hert;2ou
-3-

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eogsx bpszmieoncycuxa
01’

at!!! H93£1303

O€£°P°1 9' 1898

�v”

wwwww .-

——-r.»-

m," vac—y"-W-w—w—-nmm~mm—mm‘wﬂw—nmwn

-

m.

m‘watn

v

.

-

vw "a." “1,, w- "(WW‘

7

W." v

A

w.,ww_—..v.m.——

Dr. Harrison

~2-

October 8, 1969

WWm—

Ame.

While I would like to suggest that equivalent capsules
of chlordiazepoxide each containing 25 mg, I am not sure that
this is the best strategy. If it turns out that a clinical
effective dosage of GP 41299 is much higher than 150 mg per day,
then a comparison with 25 mg chlordiazepoxide would have a
limitation. Either the capsules could be made up now or we
might wait until we have some data to permit a better judgment.

If this preliminary protocol is satisfactory,

prepare a supplementary budget
My

request.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

«n

“www.-

~—r

Fwy-ww—

.7

,4,

r-«s-

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"Ir

.

Wm.“

wvw—‘w

*7

.

I

will

�</text>
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                    <text>“v.7,“- -- pm” yr': \ rmvnrm

October 8, 1969
Dr. D. Purpura

Albert Einstein Medical Center
Department of Anatomy
Eastchester Road
Bronx 61,

New

York

Dear Dr. Purpurn:

Enclosed are two abstracts from members of this
Department for consideration for presentation at the
Eastern EEG Meetings in December.
”A

To

Physical Model of the EEG Response
Intravenous Sodium Pentothal“

”Lateralized

Convulsions"

I

EEG

Changes

after Induced

trust these are of interest to the Society.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

u

�</text>
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                    <text>—~.

.-

«v-v—n

rm—l -—

’r‘v'av' «cw.— ..v.

.

:.-v.......».. "mm...
-

.

m.-

.

_. .

aw,”

“farm—nun.“

.

--

,

m...

..~

we,

~

ma w

»

..

. --

_.

»

.«r

.—

r

.

MW.

..

w".

,_

..

urn

_

-

~..-A

.7

,~

“7....

October 13, 1969

Prof. Dr.

N.

Polvsn, President

Turkish College of Neuropsychophsrmscology

Tslinhsne

Abdulhakhimid Cad. 76/4

Taksiu - Istanbul
Turkey

Dear Professor Polvan:

to have been nominated a corresponding
of the Thrkish College of Neuropsyohopharmscology and so pleased to accept membership. My associations with
Turkish psychiatrists have been among the most rewarding of
my professionsl (and personal) life - and I extend to the
TCNP, my best wishes for success in its meetings and publications.
I so honored

member

in

also look forward to joining
in Istanbul.

I

1970
My

you in the

first

thanks, and best personal regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr. T.

Itil,

Vice President

meetings

L

w. —.-..

,_

7““.

.V

i...

.

_

�</text>
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                    <text>.

‘wu—m .-V,.__.,—,_,

October 13, 1969

ﬂr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turen,

Please excuse

my

belated acknowledgement of the special
me - in the invitation to join the
to the meetings and to an active

honor which you accorded
T.C.N.P. I look forward

participation.
is

Your invitation to attend the initial meetings in August
welcome, and I plan to join you in a formal presentation of

our neurophysiological studies. I have mentioned
Hy Denber and he has accepted our suggestion.
I have

that the
My

just received 8.1etter

CINP

has changed

its

this to

from Heinz Lehmann

best regards.
Sincerely yours,

Professor of Psychiatry
Mszp

indicating

meeting date to August 11-15, 1970.

�</text>
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                    <text>October 13, 1969
Miss Michelle J. Cohen, R.N.
Director, Department of Education

National Association for Practical Nurse
Education and Service
1465 Broadway

New

York,

New

York 10036

Dear Miss Cohen:
Thank you once again for your kind

invitation to participate

in the National Association for Practical Nurse Education program
hesitate to accept your invitation for lunch
on October 29.
I
am
not sure that I can be away early enough; and plan to
as
the
meeting in time to hear Dr. Brill at 1 p.m.
join

presentation will be informal, and I do not ordinarily
written text, but use notes which are not
intelligible to others.
ﬂy

read from a

It is

intention to describe the programs for the treatment
of opiate addiction, including an overview of the various
my

rehabilitation

but emphasizing the
pharmacotherapy - rehabilitation approach. This View, which
includes the methadone, cyclazocine and naloxone antagonism
treatment research projects, provides (we think) the second best
and psychotherapy programs,

dilemma. (The first is prevention.)
come from our laboratories at the
New York Medical College - Metropolitan Hospital Mental Health
Center and will be supplemented by the studies of Dr. hole

to the addiction
data presented will

answer

The

at Rockefeller University.
present methadone program.

I

will also discuss the Hayor's

sufficient time for discussion and questions
floor. If a slide projector is available, I may be able
to present some of the data from tables, but this is not essential.
There will be

from the

(Slides are
I

2 x 2

inches.)

trust this is helpful,

on October 29.

and I look forward

to seeing

Sincerely yours,
uax Fink , 3m.

Professor of Psychiatry

Mszp

you

�</text>
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                    <text>October 13, 1969
Dr. Daniel P. Bobon

University of Liege
Clinique Psychiatrique
Rue Saint-Laurent, 58
Liege, Belgium

Dear Dr. Bobon:

It

gives me great pleasure to invite you to participate
in the programs of the Division of Biological Psychiatry
of this Department of Psychiatry in 1970. I look forwtrd
to having you participate in the work of the Division,

particularly in our

EEG

analytic projects.

The best time to join the Department would be during
the month of April, up to May 8, or from May 16 to mid-June.
May 8~16 is allocated to meetings of the American Psychiatric
Association and Society of Biological Psychiatry, both of
which meet in San Francisco this year.
I look ferward

to having yougbin in the

Department in the spring.

work of

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

this

�</text>
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                    <text>i

October 13, 1969

§
§
E
3

i

Dr. William Tabor
Robins Company

A. H.

:‘w’r

A

1407 Cummings Drive
Ridhmond 20, Virginia

Bill,

Dear

I look forward to seeing you on Thursday, October 23.
I suggest that you came to Gracie Square Hospital (420 East
76th Street), as it is there that I plan to undertake the
studies of butaperazine. I am enclosing a provisional protocol
more thoroughly.
for your review so that we can discuss

it

Incidentally, if you get in early enough on Wednesday,
to have dinner? I will be staying in the City
late that evening and will be pleased to have dinner with you
and your associates.

would you care

I

will ask

Kathy

to call

you on Tuesday.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf;kp

A

a—w-rvmn

.[f'r—vv-mmv

�</text>
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                    <text>w“

V. .~

m my awn-w

“mum-r: w‘».

..

..:-..

vaﬂwm

m.ww|'!l'

“9w“.

AF—mm—w

-mu.

N'w-gmvw—uw‘w-"w' my». .w—v-

—

October 17, 1969
Dr. Jerome Levine

Psychopharmacology Research Branch

National Institutes of ﬁental Health

5454 Wisconsin
Chevy Chase, Maryland
Dear

Jerry,

Following our discussions, I am writing to request
a change in the grant period as well as allocations for the
project Mﬂ-15358-03 "EEG and Human Psychopharmacology”.
We are requesting a change of the
present grant
period to 3/31/70.
.

utilize the funds in some of the restricted categories,
like to request the reallocation of available funds
as listed on the attached page dated October 25, 1969.
To
I would

Separately, we will be submitting the forms for the
continuation year, MH-13358—04, effective April 1, 1970.
Sincorely yours,
Fink, M.D.
Professor of Psychiatry

Max
NF : kp

BY:

(Mrs.) Lorraine Laskor
Director
Research Administration

�</text>
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                    <text>To:

Alfred

980%:

Max

SUBJECT:

Description of the

The

M.

Fink,

Frocdman, M.D.

DATE:

Gctober 17, 1969

H.D.

York Hodlcal Colloge-Mbtropolltan Hospital
Addiction Pregrams. as requested by Mr. C. a. King, 10/14/69.
Now

addiction treatmmnt and rosuarch programs at Metropolitan

Hospital have teen in operation since 1966.

Many modcs

of therapy

have been assassad, and the most successful has been the “pharmacologlc

rehabilitation“ approach.
substances that

In

thtse, the subjects art treated with

telltva opiate

hunger or prevent opiate dependence,

and are concurrantly continutd in an

intensivc aftercare system

to assist the davelopment of thair educational, family and job
potentials. The engagement of the subjoct by the gharmacologic.
approach has lmprcved the success of the

rehabilitation tachnlqua

alone.
Qua problem has bean

and

this is

to

dav310p morn

a goal of our programs.

we

affective antagonists

have studied mtthadone,

tybasatc, cyclazocine

and naloxone - and now contraphenaxina -

to datarnine the best

method

ané

turatlon of action.

To

of administration, their safety,
assess their efficacy,

we

havc

JaveIOpad and are the principal proponents of 'hcroin challengas'
as a tool of research and of therapy.
The present emphasis

delivery of naloxono

and

is

of

have shown tho most promise.

on

the devalopmont of improved

methadone - tho two compounds which

�7

r.

“WV—w

n.q,.... "L..._._w,...._.,».~.—. ,1 Wyn -m»—._w.n~,wm-m—uw ,,V. W

The work was dono

for

many

but since January 1969 has boon

up

.
.
M...

ﬂ...

_

out’pationt facilities

linitntions,

no have

your:

.V—mm"- w;
,

v—

','r'n~wwwmw‘iww

floor.

15A

Bocausc of

restricteé the in-pntiont

staff

program

20-22 beds; but expanded the outwpationt progrsm

subjects.

The duration of

may-w

and the

”.mw’nwvmvmnv

60~80

v—v

on words 123 and 15A

restricted to

on the 15th

-.—

to

to includo

in-pntiont care is

1-3 months;

szv

w—u

"tw

out-patient, indefinito.

We

are

now

trying to

wean a fow

qt”

Jamar-"m?“

”v.-

pationts
we

who

have boon with u: morn than

3

years.

To do so

are dovoloping a special combinod drug therapy which

toquires

some

nursing cooperation as well as medical supervision.

our program admit: approximately one patient each day, and
has a waiting
The

list

principal

l.

of 60-100 at any time.
forms of therapy and a comoon sequence

is:

withdrawal and detoxification using

decreasing amounts of methadone;
2.

Social service evaluation; group therapy;

3.

Educational evaluation and introduction to

v

retraining;

-,-

r
"rur‘

-—

Wm

n
&lt;

wresaswv"

4.

Medical evaluation and therapy of medical conditions;

5.

Induction

on

antagonists (metﬁaéono, cyclazocine,

naloxono);

navy-tau-

6. Heroin challenges;
7.

Aftorcaro, with the appropriate thoropy: rehabilitation,
group therapy, social casework, and

phornacological monitoring.

�1

ml

“7".“ ,__ ,y-uv— m-w my"-

vuwwl'ﬂ-ivrrwvwx

_‘

"u:r.v'T“'!‘--v-errl"

-—:——mw~;—-_

——-m‘

-

._————-

1.....—

Wﬂvw—mu—

In response to suggestions for the immediate future,
I would emphasize

that

no therapy has been

tested to warrant general

and

sufficiently

indiscriminate application.

despite the severity of the problem.

The dengere

of each

approach are poorly understood and any mandatory program

(especially

if

carrieé out

lalty) will provide

by untrained

the basis for more harm than good.

Efforts at developing better pﬁermeeologic agents,
the trial of storefront. non-hoepitalcentered units for
delivery of antagonists, special oducetionel unite in the
especlally 1n the schools and the health centers
to involve the users in the treatmont programs, and better
community,

general medical care of the addicted are

that are logical

now.

A

of the steps

broad scale methadone-rehabilitation

program should be available to

project

some

all

who

volunteer.

One

would be the development of a long-acting neloxone.

ee potentially the most useful pharmacologic tool at
From

the point of

View

of the report,

we

would

be labelled as:

Experimental-research:

60%

Care and therepy:

40%

Fink, M.D.
Professor of Psychiatry

Mex

MP:kp

specific

this time.
best

�</text>
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                    <text>October 17, 1969

President
Eastern Airlines
Executive Offices
10 Rockefeller Plaza

New

Dear

York,

New

York

Sir:

Shuttle from New York to Washington, the stewardesses
insisted that they do not have tax exempt forms. When I
indicated that I would pay at the terminal, the stewardess
refused, insisting that they must be paid before the flight
is completed. Institutional regulations require that all
flights must be on a tax exempt basis. Since the appropriate
forms are maintained at ticket counters, is it too much to
ask that they be made a standard part on the service carts
0n the

on your

flights?

is a tax exempt form and a xerox copy of the
flight certificate. I would request credit for $1.10,
reflecting the tax which should not have been collected.
Enclosed

Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>October 17, 1969
Dr. waiter Modell, Editor
Pharmacology 3 Therapeutics

Clinical

Cornell University Medical College
1300 York Avenue
York, New York 10021

New

Dear Dr. Modell:
I

am

pleased that our report "Clinical Antidepressant
A Narcotic Antagonist” has been

Activity of Cyclazocine accepted for publication.
Page 12

necessary.

if

Enclosed
Thank you

Figure

is

an

1

and no

abstract

additional pages are

as requested.

for your consideration.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MP

:kp

�</text>
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                    <text>w if,“

M.

wavy-wwwwx-v

WWY'WWM‘IIJ'T'&gt;W‘m—wwﬂw

-~ 'wrﬁ-H-

7,.
“haw.-.“ «n 1." ,,,_ —y.—,......._..v..¢,,__‘_,.,m“Hi—"wrm,

w...

....._-

‘

.mw-urur ..

0

&lt;35

October 17, 1968

ﬂea: Alex,
Enclosed are our eorrnctions 1n the calluy of the
cyclazoctne«zﬂc raport. The figures and lngauda are not
inuludcd and, parhapa, 1t ﬁbula be useful for us to see than
again before they are published.

Incidentally,

no

raprin: crdar

farm

is enclosed..

Sinéaroly yours.

Max

aﬁ/

Pink,

M.D.

.M

‘

...,_.,.,,

pﬁn

7..

...

-

.._.,

.

n. .._r_ m.

‘

.M

.

‘

,, ,

�</text>
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                    <text>chober '9,

lngrisano
Radiation Sys+ems, inc.
McLean, Virginia

Mr. M.N.

£969

Dear Mr. ingrisano.
Thank you for *ha informa+!on on fhe fympanlc
have read wlfh infarasf. Ha are tn 5 position
uhtch
fhermomefer.
+0 underfake #hese sfudies, but bofare
submlf a firm order, wouid
fha
dwmonsfraflon
of
for
a
nifhor
equtpmenf, or an optton +0
ask,
canes! affer 15 days.
I

I

.

New

I woutd
prefer a demonstraf!on. ls fhe machine in
York or can one of your represanfafives demonstrafe !? at our

£aboraforles

?

Many

fhankg.

Sinceraiy yours,
Max

F!nk, M.D.

Professor of Psychlafry

�</text>
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                    <text>Ociober i9, i969
Dr. David Mofcalf
Colorado Psychiatric Hospliai
Dower, (So i orodo
Dear Dave,
would
in
and
March,
meefings
1

like lo parilcipaie in the Wosforn
my application form is onclosed.

EEG

l meniiomad fho
rump session of fha
i
+0 run in New York. The moofing
+haf
inlandod
EEG/Psychia+ris+s
was held and if was qulle succassful. More fhan 30 people showed up,
and we had a good discussion of The merits of EE$ in psychiatry. The
iimlfafions more also discussed, and while fhose seamed moro
formidable fhan ihe applicafions, inere was consensus fha? fhe prosen?
sfudy programs. particularly in relating EEG changes +0 opacific
aspecls of bahavior, were going very wall. When i have fhe chance
viii summarize The moefing and sand you a copy. There may yet be
formal meetings of fhose inferesfod in man’s behavioral changos and

in San Diego,

I

The EEG

correlates.
My

heal regards.
Sincerely yours,
Max

Fink, M.ﬂ.

Profossor of Psychiafry
mf/

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                    <text>mmmrﬂvmmw

.

4‘. mr‘

‘

,

m- ,«u at

r,

'a

&gt; ._

-_

m... 1..

.

t

v. mo. 4.3-...- wan

snl‘WBr'f.‘

—--.w--.....--v.,»

n:— . («.m'ci‘au', "-m-nv'l‘ wan-rum

my...“
‘w"-‘-‘nl"=4l-w'rww——~-vv-uvvaw-u|q|w.“”"m'\mv—1m

.....

,r—n

~ -»

October 20, 1969
Honorable Jacob Javitz
United States Senate
Washington 25, D.C.
Dear Senator
I

am

Javitz:

indeed grateful for your kind response to

my

regarding our role in the Viet Nam War. I wish
to commend your statements as published during the last
few days.
comments

I am writing to bring to your attention one of the
consequences of the present administration. Enclosed are
xerox capies of letters which I have received in my role

as a research scientist. These letters have been received
from the National Institute of Mental Health, both from the
Director, Dr. Yolles, and one of his assistants.

Our budgets for the coming year have been cut and we
be able to adjust. To do so it will be necessary to
curtail the hiring of new personnel and as usual, the impact
will most he felt by the trainees in our program.

will

Perhaps the most significant problems that we face
some of the new ideas that we have developed no
longer meet a receptive ear in Washington. I should like
to bring to your attention that on Wednesday - Viet Nam
Moratorium Day - I visited with officers of the Rational
Institute of Mental health to discuss with them some significant
advances in the treatment of opiate addiction and to request
their consideration of a contract in a sum under $100,000 -

is that

to provide

a means of extending the efficacy of a most useful
treatment of opiate dependence. I was told that no contract
funds were available and that we should utilize the conventional
grant mechanism - although the likelihood was just as bleak.

Our programs are reasonably well funded and we will survive
the present restrictions. The impact on new programs, on new trainees
will not be felt for many years. If this is one of the consequences
of the Viet Nam War, any help that you can give to returning an
emphasis on the part of this country to support of life rather
than the support of death will be deeply appreciated.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

~vwm‘Wu ,_,_
~

,

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                    <text>w

uw-w—vuv”a,

October 20, 1969
Honorable Lester Wolff

House of Representatives
Washington 25, D.C.
Dear Mr. Wolff:
I am indeed grateful for your kind response
comments regarding our role in the Viet Nam War.

to

few

commend

days.

to

your statements as published during the

my

I wish

last

I on writing to bring to your attention one of the
consequences of the present administration. Enclosed are
xerox copies of letters which I have received in my role
es a research scientist. These letters have been received
from the National Institute of Mental Health, both from the

Director,

Dr. Yolles, and one of

Our budgets

his assistants.

for the coming year have heen cut

and we

will be able to adjust. To do so it will be necessary to
curtail the hiring of new personnel and as usual, the impact
will most be felt by the trainees in our program.
Perhaps the most significant problems that

we face
ideas that we have deveIOped no
longer meet a receptive ear in Washington. 1 should like
to bring to your attention that on Wednesday - Viet Nam
Moratorium Day - I visited with officers of the National
Institute of Mental Health to discuss with them some significant
advances in the treatment of opiate addiction and to request
their consideration of a contract in a sum under $100,000 to provide a means of extending the efficacy of a most useful
treatment of opiate dependence. I was told that no contract
funds were available and that we should utilize the conventional
grant mechanism ~ although the likelihood was just as bleak.

is that

some

of the

new

Our programs are reasonably well funded and we will survive
the present restrictions. The impact on new programs, on new trainees
will not be felt for many years. If this is one of the consequences
of the Viet Nam War, any help that you can give to returning an
emphasis on the part of this country to support of life rather
than the support of death will be deeply appreciated.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>October 20, 1969
Honorable Charles E. Goodall
United States Senate
Washington 25, D.C.
Dear Senator Goodell:
War

I wish to commend you for your position on the Viet Nam
and take this opportunity to bring to your attention some

of the results of the present disastrous governmental policies.
I am writing to bring to your attention one of the
consequences of the present administration. Enclosed are
xerox copies of letters which I have received in my role
as a research scientist. These letters have been received
from the National Institute of Mental Health, both from the

Director,

Dr. Yolles, and one of

Our budgets

his assistants.

for the coming year have been cut and

we

will be able to adjust. To do so it will be necessary to
curtail the hiring of new personnel and as usual, the impact
will most be felt by the trainees in our program.
Perhaps the most significant problems that we face
some of the new ideas that we have developed no
longer meet a receptive ear in Washington. I should like
to bring to your attention that on Wednesday - Viet Nam
Moratorium Day - I visited with officers of the National
Institute of Mental Health to discuss with them some significant
advances in the treatment of opiate addiction and to request
their consideration of a contract in a sum under $100,000

is that

—

to provide

a means of extending the efficacy of a most useful
treatment of opiate dependence. I was told that no contract
funds were available and that we should utilize the conventional
grant mechanism - although the likelihood was just as bleak.
Our programs are reasonably well funded and we will survive
the present restrictions. The impace on new programs, on new trainees
will not be felt for many years. If this is one of the consequences
of the Viet Nam War, any help that you can give to returning an
emphasis on the part of this country to support of life rather
than the support of death will be deeply appreciated.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF

:kp

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                    <text>October 20, 1969
Dr. Dieter Bente
"
Oberarzt der Universitats-Nervenklinik
Schwabachanlage 10
8520 Erlangen
Bayern , Germany

Dear Dieter:

It was kind of you to invite our participation in the
of the German CINP. The topic ”Drug Abuse
symposium
next
and Addiction! is of particular interest to us and perhaps
we should participate. You may know that we have been

studying narcotic antagonists in the treatment of opiate
dependence for more than three years and a presentation
on the subject ”Narcotic Antagonists in the Study and Therapy
of Opiate Dependence" would permit a review of our experience
with cyclazocine, naloxone, tybamate and methadone. Given the
time, we would also discuss the EEG changes and heroin challenges.
In

this report,

and Arthur Zaks.

I do not know

my

co-authors will be Drs. Alfred

M.

Freedman

if

marijuana and cannabis have become
a problem in Germany, but if you wish, Dr. Freedman would
consider a report on our experimental studies of marijuana
and THC ("Experimental Studies of Marijuana and THC in
Volunteers“).
I

trust this reaches

you in time.

Our meeting on September 25, on EEG and psychiatry was
quite interesting and I believe successful. The group did

not wish to organize a Berger Society as yet, but did think
that we should meet again, probably on the occasion of the
meeting of the World Psychiatric Association in 1971. To
that end, I have agreed to try to arrange such a symposium
and have already written to the organizers of the meeting.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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                    <text>1,. 431(1).
W
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New York, ﬂew York 10029

October 21, 1969

ﬁr. Benis Leigh
Secretary-General,
Maudsley Hospital

World

Psychiatric Association

Denmark Hill
London 5 S.E., ﬁngland

Sear ﬁr. Leigh:
For many years I have been interested in the applications

of electroencephalography to psychiatry. At the 1961 World
Congress of Psychiatry 1 chaired a symposium on BBC and woman
PsychOpharnecology, which was summarized in the EEG Journsl,

In subsequent years, meetings of psychiatrist ~
electroencephalographers have been held in association with
1963.

the Society of Biological Psychiatry, the
in rushingtoo and the latest, in association with the
International EEG in San Diego. This latter meeting was held
in my laboratories in New York on September 25, and was attended
by 24 visitors from nine countries.
It was the consensus that
similar meetings should be held and ideally the members agreed
that the Worlé Psychiatric Association represented the best
the

CIR?

German ClﬁP,

forum.

Recently, Br. Jonathon Cole brought to my attention
the fact that the EPA has established sections on diverse
aspects of psychiatry. Prior to my discussion with 9r. Cole,
I had written to Dr. do la Fuente regarding a symposium on
EEG and psychiatry during the Vth loternetionel Congress in
Mexico City in l971. He expressed interest in this suggestion
and plonned to discuss it with the Executive Committee.
of

1

EEG

an writing to propose the establishment of a section
and Psychiatry within the world ?sychiatric Association.

It is my belief that there is general interest in the applications
of this tool, developed 40 years ago by the psychiatrist,
Dr. Hans aergor, and I believe such a section will not only be
productive for the scientists directly involved, but also for
the many psychiatrists of diverse interests who attend the
world Congresses.

Hey I have your advice on how

to proceed?

Sincerely yours,
ﬂex Fink, M.B.

Professor of Psychiatry

MP :32)?

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                    <text>my”,

a-v

.

rv-uvg-nm

October 21, 1969
Dr. John A. Scigliano, Ph.D.

Executive Secretary
ad hoc Marijuana Advisory Committee
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:
As the letter from Dr. Coy Waller indicated, the samples
of haahieh which we obtained in Athens are active but 'impure'.
His note and his comments during a visit to us suggest that
NIMH has, or may have available soon, supplies more active in
THC-A-9 and less in cannabidiola.
We are now beginning a series of better controlled studies
of the behavioral and EEG effects of marijuana (NIMH sample)
and hashish (our Athena sample). We would prefer to work with
supplies that are more 'pure', and I am writing to ask that you
keep us in mind and make supplies available to this laboratory

when

these become available.

Thank you

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>OctOber 21, 1969
Dr. Coy w. Waller

Research Institute of Pharmaceutical
Sciences
The University of Mississippi School

of Pharmacy
University, Mississippi 38677
Sear Dr. Waller:
Thank you

for your analysis of our hashlsh sample.
A9

content of our marijuana samples,
In relation to the THC
greater effects. The NIMﬂ sample
this material should yield THC
is an active base for cannabis
contains 1.31% THC, and if
action, the hashish should give some effects. But your taken
comment about the need for more "pure" samples is well
and I am writing to Dr. Scigllano to ask for a supply as soon
as avai lab lo .

will

Dr. Miras' analyses have not yet been received and I
send them to you as soon as I get them.

for better defined samples is emphasized by
your note, and I am gratefﬂl for the comments, and agree.
Many, many thanks for your prompt analysis.
The need

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf:kp

�</text>
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                  <elementText elementTextId="103065">
                    <text>October 21, 1969
TO:

Mr. Schwartz

FROM:

Dr. Fink

I have received a request
rooms:

for shades in the following

Room 1539a
Room 1589b
Room 1589c
Room

158910

Room 1589 4
Room 1589 -

Main

Office

H

yellow

~

104 "
H

H

2
2

Dark Green - 104 "
yellow - 104 "
yellow —72 "

1

yellow

6

—

72 ”

These rooms are used not only by the Division of Biological
Psychiatry, but also by the Training Division and soon by
Dr. Denholtz.

MF

:kp

�</text>
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                    <text>October 22, 1969
U.S. Bureau of Narcotics
1405 I

Street,

N.w.

&amp;

Dangerous Drugs

washington, D.C. 20530

Attention:
Dear

John Mayer

Sir:

May I request 10 grams of recrystalized purified
heroin for oxyerimental studios in the Department of
Psychiatry, New York Medical College? Our present supply
will be exhausted within two weeks.
We

have continued to assay the duration of action of

oral administration by
"heroin challenges“. This technique, monitored by the EEG,
provides an accurate index of antagonists and cross-tolerance.
The work is in progress in the laboratories of the Department
at Metropolitan Hospital and 5 East 102nd Street.
methadone and naloxone on chronic

Thank you

for your couperation.
Sincerely yours,
Max

Fink, M.B.

Professor of Psychiatry

HF : kp

cc:

Mr. Tagley

�</text>
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                    <text>L-“v-J-w-n »~-&lt;&gt;-

‘r-L':)1'|~:v»w-1'IV-rr

7.7..,.,;~.7~..

.‘

W

. .975
m V‘H‘JW‘VI’W.’V‘.

.v—n

V

v" “- . .m,

October 22, 1969
Dr. Enoch Callaway
Tho Langley-Porter Neuropsychiatric
401 Parnassus Blvd.
San Francisco, California 94122

Clinic

Dear Noch,

of the Winter Brain Conference came
from your office and I look forward to attending. I trust
we both can make it this year.
The announcement

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>October 23, 1969

J. Russell Taylor
Philadelphia General Hospital
ﬁahnemann Medical Service
Civic Center Blvd.
Philadelphia, Pennsylvania 19104
Dr.

W.

Dear Dr. Taylor:

to

Thank you for your kind invitation, and I look forward
joining you on Wednesday, ﬁovember 25, about noon, in

the Mills Building auditorium or

Max

PRH

Cafeteria.

May I ask that I be listed by my abbreviated name,
Fink, M.D.? Somekbl, the Maximilian has always seemed

too formal.

Incidentally,

I would

like to use

2 x 2

slides.

Sincerely yours,
Max

Fink, w.o.

Professor of Psychiatry

MF:kp

�</text>
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                  <elementText elementTextId="103061">
                    <text>Catcher 23, 1969
\

Dear Joe,
Thank you
change tha

for the

APPA

program.

It

looks good.

0n the cover pug» for the printad program, please
non~uambers to threa dollars.

registration tea for
For the Dutch

Trltt Catktail party, is: it necessary
7

to indicate that 'canapen, courtaay of the associatiau'

deletc

it.

Thaddeaignation

inconsistent with the other

I

would

far on: lacturer as Prof. Dr. is
Aftar all, there are a few
1t is worn democratic 3nd less

titles.

Professors on the program, and
obelaant to designate Br. Hippiua in the
Elkea, Eisenberg, Katy, etc.

same way an

Graonblatt,

Finally, the summary I sent'you was too long.
I sent a second. and even this may be too long. Please use the
second or edit it further.
My

hast regards.
Sincerely years,
Max

Joraph Zubin. ?h.D.
Biometrics Research
722 What 168

New

York City

Street

Fink,

M.D.

�</text>
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October 24, 1969
Dr. Harvey Tompkins

St. Vincent's Hospital
153 West 11th

New

York,

New

Street

York 10011

Dear Dr. Tompkins:

attached letter has been sent to Dr. Denis Leigh
in the hope of advancing the development of an international
”Berger Society”. Perhaps the best umbrella is the WPA.
The

Your cooperation

is appreciated.
Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp

,,

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M...“ 7..

‘41-:

"er

-

,

—mp—-urﬂmu

‘

“av,

-

October 24, 1969
Mr. Hal

Specter, Publisher

Technology Publishing Corp.
647 North Sepulveda Blvd.
Los Angeles, California 90049
Dear Mr. Spector:
Thank you

for your recent letter to the

APPA.

Comprehensive Psychiatry, as its official
Comprehensive Psychiatry is published by Grune and

utilizes

The

Society

journal.
Stratton.

I have sent copies of your letter to the president and
will arrange to have your offer discussed at the next council
‘

meeting.

Sincerely yours,
Fink,
Secretary

Max

Mszp

MD

�</text>
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October 24, 1969
Dr. Harvey Tompkins

St. Vincent's Hospital
153 West 11th

New

York,

New

Street

York 10011

mm-

funny-r1”

Dear Dr. Tompkins:
The attached letter has been sent to Dr. Denis Leigh
in the hope of advancing the deveIOpment of an international
"Berger Society". Perhaps the best umbrella is the WPA.

Your cooperation

is appreciated.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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Dr.

Fritz

A.

New

York,

New

Freyhan

St. Vincent's Hospital
153 West 11th Street
Dear

York 10011

Fritz,

enclosed letter was received. I subscribe to
one of the journals, Telemetry Journal. it is well done,
and perhaps, considering their unusual guarantee of
$1000/year and the history of problems with Dr. Stratton,
we should put this item on the 1970 agenda.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>\w‘lz’l‘T-VIWJ'

wanna.

"7w.

:II'J"

rim!)

:wv-—u»7mr'rrmmmm

“Wan-r

mum

«a:

0le

A.

v'

«Ix-urn:

wwwmmw

'

October 24, 1969

Editor

New
New

Dear

York Times

York,

New

York

Sir:

recent change in the Federal Government's position
regarding penalties for possession of marijuana is indeed
salutary. But your support of the Administration's change in
position was combined with support for another commission to
study marijuana - the bill suggested by Senator Moss and
Congressman Koch. Such a commission is unnecessary and
wasteful of funds; it can serve only to delay the research
efforts which already have been stimulated by the National
Institute of Mental Health, but which remain unfunded.
The

There have been many studies of the “marijuana problem” beginning with the Indian Commission in the last century up
to the extensive English Marijuana Commission Report of 1968.
Each commission finds we lack facts regarding the effects of
short term and long term use of cannabis. Is cannabis addictive?
Does it lead to use and addiction of opiates? Does cannabis
use lead to permanent brain damage?
In 1965,

NIMH

arranged a meeting of

stimulate proposals to

scientists to elicit

answer these questions. Many of
the recommendations have already been implemented and studies
are in progress. The recommendations included the development
and

of defined strains of cannabis with high content of some of
the presumed active components of cannabis, such as the
tetrahydrocannabinols. Projects to provide rapid assays for
the components of cannabis, and animal studies to determine
the long term toxic effects have been proposed. Studies
have been elicited to measure the effects of acute and chronic
smoking of cannabis on perception, mood, affect and driving.
Some proposals have been elicited to study the sociology of
cannabis use, including patterns of contageousness. Proposals
have not been limited to studies in the U.S., for scientists
have suggested investigations in areas like the Near East,
where cannabis use has been long standing and more socially
acceptable, to determine the incidence and severity of chronic
brain syndromes or other toxic effects.

�Editor,

New

York Times

-2~

October 24, 1969

We have recently been advised that many proposals may
not be funded because of limitations in the contract fonds
of NIH”. Considering the number of scientists NIMH has
been able to stimulate to look at the marijuana problem, the

need seems more for additional funds to allow scientists,
grantees and contractors of NIMH to carry out studies already
approved by expert committees which remain unfunded. Surely,
this is a more worthwhile approach than the allocation of
thousands or hundreds of thousands of dollars once again to
decide what should be studied.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry
Birector, Division of Biological Psychiatry
New York ﬁedical College

MF:kp

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                    <text>October 27, 1969

Professor Karolina Jus, M.D.
Klinika Psychiatryczna A.M.

ul. Nowowiejska 27
Warsaw, Poland
Dear Dr. Jus:

letter that I have just sent
that you or Andrzej can give
help
to
to this mission will be appreciated.
Enclosed

is a

Dr. Denis Leigh.

copy of a
Any

I very much enjoyed your

seeing you again.

visit here

and look forward

to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF2kp

'

we‘m‘

�</text>
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“x ~'1L'erwi-lwl~."r"

-

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&gt;

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_

'I'Iwm'xa"1- 1 .Wu nay-rur-

October 28, 1969

Editor

England Journal of Medicine
lO‘Shettuck Street
Boston, Massachusetts 02115

New

Dear

Sir:

Pitts

and McClure (N.£ng.louh.Mcd., 1967, 311; 1329-1336)
reported that intravenously administered sodium lactate precipitated
a severe anxiety attack in 93% of individuals diagnosed as anxiety
neurotics but in only 20% of normal controls. They were also
able to minimize the effects of lactate by intravenous calcium.

undertook a replication of this study, using their
techniques and, with their couperation, their lactate solutions.
In five patients with lactate, each patient covelopcd acute
anxiety between the 3th to 12th minute of infusion, peaked
at 15 minutes, and remained seVero for 15 to 30 minutes.
Each patient experienced "after effects” of irritability,
dysphoria, tension, fatigue and weakness For 2~7 days.
We

to lactate/calcium was similar to lactate
alone, but significantly‘less in intensity and duration; and
there were no “after-effects”. There was no patient response
to dextrose/saline.
The response

In feur control subjects, the response to lactate was
characterized by tachycardia and restlessness, but without
anxiety in 5 subjects, nor ”after effects“ in four. Anxiety
was elicited in one control. The controls become drowsy and
bored with lactate/calcium and éextrose/saline.
Ac

with

Pitts

able to correctly

and McClure, a “blind” investigator was
name 25/27 solutions (92.5%); the patients

13/15 solutions (87%); and the controls 6/12 solutions (50%).

In concurrent scalp recorded cloctroencephalograms, we
observed changes with lactate in the patients, not shared by
the controls or by dextrose/saline and lactate/calcium solutions.
The EEG exhibited increased beta and decreased alpha abundances
end a decreased alpha amelitude. These findings are consistent

with the

EEG

changes usually seen in anxiety

states.

�Editor,

by

New

Eng.

J.

-2-

Med.

lactate are well summarized
would also add to their formulations
these observations have two interesting applications. A

Hypotheses relating anxiety and

Pitts

that

and McClure.

We

lactate tolerance test provides

Twwﬂu.

October 28, 1969

a group of mentally

ill

with

an

common

means of identifying
characteristics of anxiety

objective

neurosis, for both therapeutic and prognostic trials. The
antagonism of calcium to lactate precipitated anxiety and its
successful therapeutic trial (Pitts, personal communication)
suggests that other anti-anxiety agents may be tested using

'

u:
-

this

model.

‘

Sincerely yours,

.~.

3.:

”WW

uwna-w

P".-

5“an

Fink ,

:‘I

o

D

e

'wzawr-mxz‘

.

.mﬂm’mﬂP'W‘

Michael Alan Taylor, M.D.

Jan Volavka,
MF

:kp

M.D.

�</text>
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                    <text>:‘nn'lw‘

—

rﬂn"7rl

'rn‘

:A—wx-nwnvx-

wo-H'f-‘rr'

yup-.4:

v'r'I-WHI

vw'n'mw‘”

‘

October 31, 1969
Dr. Michael Taylor
9309 Murillo Avenue

Oakland, California 94605
Bear Mickie,
We

Enclosed is a letter from Dr. Kety which I opened.
have sent a second copy as he asks.

Enclosed is the letter to the Nov Engiand Jouﬂnaﬁ
05 Medicine which, if you sign, should be sent airectly.
The latest issue of the Aaahiucb 05 $enexa£ Paychéatny

'iwl'v

iwﬂ‘w

.

which I received last night contains an article by Grosz
which attacks the Pitts and McClure report quite strongly.
A xerox copy is encloded.

that I do not understand the argument
feel that our work supports Pitts and ﬂcClure
sufficiently to send the enclosed letter. I even thought
of sending the letter to the Anchivcb oﬁ Genehaﬁ Pégchiaiag,
but this is not appropriate since we are not answering the
Grosz argument, but reflecting on the original paper.
_

and

I must admit

still

I have

taken the liberty of sending

original letter to ﬁr. Pitts.
and

a copy

of the

started the study of penicillamine
of the usual difficulties but is enjoying

Dick Abrams has

is meeting

the work.

Keep up

some

the good work!
Sincerely yours,
Max

Fink , $4.1).

Professor of Psychiatry

Mszp
HI!

w
‘

"Na?“

�</text>
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                    <text>rOctObsr 31, 1969
Dr.

william“a. Tabor

A. H. Rabins Company
1407 ComMings Brive

Richmond,

Virginia 23220

Dear 8111,

It

Special pleasure to have you, Hunter and Bob
visit Gracie Square last Thursday. I tried to present the
point of View that the efficacy of psychoactive compounds Can
be significantly enhanced if the patients take their modication
regularly, and intake can be improvea if the medication is
presentod in a palatable fashion.
was a

this

ﬁrs. Fritz Freyhan
Friedhoff to discuss training. in psychopharmacology.
Dr. Friedhoff spontaneouslv and independently stated that he
hadﬁgreat difficultywasin toachiM his studentsa at Kew York
insufficient to-givo patient a
University that it
prescription. Tho physician must insure the patients' compliance
with the instructions. ﬁr. Freyhan concurred when I inquired
as to how one insured the patient's intake, they both agreed
parenteral routes were the best and liquid preparations an
important need.
on rueséay of

and Arnold

On

Monday I was

week I met with

told that thlothixene

(Navano)

oral

concentrate had been ayprovod by the FDA at the orofessional
level and that it awaited the final administrative approval,
which was expected within two weeks.
Two

.

150 mg as

oatients are

of today.

find no consistent
Come

visit

on Aha-1900. one at 409 mg and one at
I have reviewed the available HES éata and
changes in dosages ugwto 200 mg/day.

we

again.

My

best regards.

Sincerely yours,

I

Mszp
cc:

Mr. Hunter Spencer

Mr. Robert Nickless

Dr. J at):

med

Fink, .Moi).
Professor of Psychiatry

E‘iax

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                    <text>WWW

.

paw

'

Octobar 31, 1969
Mr. William Spear
The Wildwood Inn
Box

5037

Snowmass—at—Aspen, Colorado 81611

Dear Mr. Spear:

reservation for Dr. Max Pink and
arriving January 25, and leaving'
I
will be attending the Winter Conference on
January 30.
Brain Research. I will require a twin bedded double room.
Please

make a

Miss Linda Fink,

Sincerely years,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

�</text>
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October 31, 1969

Dr. Coy W. Waller
Research Institute of Pharmaceutical
Sciences
The University of Mississippi School

of Pharmacy
University, Mississippi 38677
Dear Dr.

wallet:

impose on your experience once again? We
have been sold a sample of presumﬂd “marijuana“ which
In two exparimeuts with
we believe to be nregano.
May I

volunteers

we

elicited behavioral effects but not the

visceral effects of marijuana.
oregano has a content of
as a

Can you

advisa

me

THC?

ﬂo you knew

Any

if

commerttal

other hallucinogens?

whether oregano has been studiad

possible "placebo? for marijuana~typa studies?
ﬁany thanks.

Sinceraly yours,
ﬂax Fink, M.D.

Professar of Psychiatry

n¥=kp

�</text>
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October 31, 1969
Dr. Simeon Locke
Boston State Hospital

Neurological Unit

Boston, Massachusetts 02124

Dear Dr. Locke:
I am honored and pleased to accept your invitation
to participate in the Thursday afternoon conferences at
the Boston State Hospital on January 15, 1970. It is
possible for me tojoin you earlier in the day. As I
understand your note, it would be two presentations quantitative EEG analysis in psychoPharmacology and drug
induced denial as an index of organic brain disease. The
order is whichever is most suitable for you. I will be
bringing 3 1/4 x 4 1/4 slides.
Thank you

for your invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>‘.

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October 31, 1969
Dr. Ferris Pitts
Washington University School of Medicine
4940 Audubon
St. Louis, Missouri 63110
Dear Pete,
We completed our study of sodium lactate and when we
summarized the data found that we contributed very little
in addition to what you had presented. A copy of our interim
report is enclosed. Nevertheless, it seemed worthwhile to
include a statement in the literature that your work was
confirmed. My associates and I have, therefore, drafted the
enclosed letter which has been sent to the New Engﬂand
Joannal 05 Medicine. I trust
will appear and it should
permit you to refer to the work of this laboratory as
confirming the data presented in 1967.

it

This may become important since the Aachtveé 05
Genaaaﬁ Paychéatag contained some criticism of your work
which I must admit was not too clear to me.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>w.

Nwanlnﬁm

-v

.

Viv-wow.“

1-,

~wnmw~,_v—wwr

~

saw-7w“... .-.

auto-yrr'm‘N-r 4‘

"n "w mm ww’vm‘“W's-mm-:«--v~v,vn‘ww.

October 31, 1969
Krohn~Hite Corp.
580 Massachusetts Ave.

Cambridge, Massachusetts 02139
Gentlemen:
May

I please haye a recent condensed catelogue,
and the

particularly of your variable electronic filters,

name

of year local representative.

I am

interested in

It

would be usefhl
an

to have him contact me as
equivalent to the Krohn~Hlte 355R.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>"-V-W‘m

vnr-vn—rcam.v-w-uwrwmwn,.u— .
n—r

‘

v-pm

v

mwu »

w

'

.

r: nun»: wwmvwﬁv

--1

v

a“. "q” H

. v,

“n...“

h

r.

1,1.

wrw:

«WV'C‘VTJP w

June 27, 1969
Mina Anne Walker
15

Littel

Road

Broohline, Haaeachuaetta 02l£6

Deer Hiaa walker:

I wrote in reopocee to your request,
reflect the actual data of interest to

Encloeed are acne notes

and a few

reprints

which

ia, of course, much more data, ea in animal atudiee
electrodes and druge are introduced into specific brain
areas for specific relationahipe to behavior, in human atudiee
with electrical techniques which are not used in my laboratory
(as evoked potentiale and contingent negative variation); and
me.

where

There

with druge not usually defined an psychotropic (anticouvuleanto,
her-ones, vitamins, etc.).

If theee are useful or interesting, I would he pleaaed to
vieit the laboratory for a review of the nethode; and

have you

to anaver queetiona which must arise fro: ouch discursive notee.

The euhject of brain function, drugs and electrical activity
ie an important one. and ite etory needs telling. I an terribly
eorry that I an ac poorly equipped. but perhape your experience
and talent can eelvege this tale.
Good luck!

Sincerehryoura,
Me: Pink, 11.0.

Profeeeor of Psychiatry

'1‘
&lt;

'
‘
:vr

“’WﬁWFMWWW-Hli‘

"m

Avam-p.

-

"Y’Wﬁ'ﬂ':vv~“n‘:uw

'H‘?

Mfzkp

.

«mgr—”pun

/

-

ww-

’h.’

av

.7-‘1'Mw’r‘

�</text>
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                    <text>'1;

July 2. 1969
Dr. Robert Ornstein
Department of Mental Hygiene

The Langley

Porter Neuropsychiatric Institute

401 Parnassus Avenue
San Francisco. California 94122
Dear Bob .
I have

recently re-read your findiproposal when we discussed
another report. seemingly related - that of Barbara Brown on the
"Rec nition of Aspects of Consciousness Through Association with
EEG A pha Activity Re resented by a
Light Signal.‘I Her report.
and your studies high ight the important changes occurring in
the CNS as a result of inter.“ cues. Hhat may be useful is the
description (in both reports) of enhanced alpha
litudes.
synchrony (perhaps) and percent time (even with ED accomanied
by pleasant sensations and ”reduced" awareness - the latter
clear in Brain‘s study and implied (perhaps, again) in the
"focussed" attention in yours.
The

suggestions for period analysis in your study will

probably answer some of your questions. althou h the qualitative
changes which are described as ”synchrony” wil probably be as
important. A auantitative method to evaluate synchrony might be
derived from cross-power spectra or correlational analyses.

-

If you do not know of Brown's work, I suggest you write to
her (V.A. Hospital. Sepulveda. California). But I presume you
do. already.
Good

luck:
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp
-

,..-v,-v.—,-Av.—u—--.gx

.

vex-r

i

�</text>
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                    <text>July 3. 1969
6. Grodberg. Director
Research and Development

Mr. Marcus

Davies Rose Hoyt
633 highland Avenue
Needham. Massachusetts 02194
Dear Mr. Grodberg:

principal phase
study program are:
The

Sidney Merlis

Arthur Sugerman
Donald Gallant
George Simpson

I drug

evaluators of the

HIMH-ECDEU

Central Islip State Hospital, N.Y.
new Jersey Neuropsychiatric Institute
Tulane University
Rockland State Hospital

men are accustomed to evaluating new psychoactive drugs,
but do not usually report studies of sedatives.
There are also a number of fine researchers in Europe who
are now doing phase-I studies. often at a cost less than USS.
investigators. and with U.S. investigators as monitors or co—
analysts. In one study, the data was prepared on NIMH-type
forms and analyzed here. There has been some discussion as to
whether such trials can be included in an FDA submission. This
objection to foreign work is to my mind, not relevant in phase I
studies. where drug toxicity and dosage are the principal questions.

These

If such a European trial interests you. my laboratory may be
able to monitor and process the data. One advantage of a European
trial is the possibility that some EEG data for classification
purposes may be obtained concurrently.

It

was kind

suggestions

may

of you to

be

helpful.

visit

my

laboratory.

I

trust these

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July 3.
Dr. 01drich Vinar

The George Washington

1969

University

Biometric Laboratory
1145 Nineteenth Street, N.H.,
Washington. 0.6. 20036

Room

618

Dear Dr. Vinar:
I am honored by the opportunity to
organize a symposium
on abuse of amphetamines and ha11ucinogens for the 1970 CINP

meeting in Prague.

1

have a1ready received a kind and
and look forward

enthusiastic 1etter from Professor Kie1hoiz.
to working with him.
Thank you

for this fine opportunity.
Sincere1y yours .

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

P.S.

I sti11 hope that your visit to New York may be
possib1e.
Dr. Hatousek has sent me your latest
on EEG criteria
report
for se1ection of psychoactive drugs, and
is cha11enging.

it

�</text>
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                    <text>July 3. 1969
Dr.

J.

S.

Gottlieb, Director

Lafayette Clinic
95l East Lafayette

Detroit.

Michigan 48207

Dear Jacques ,

l was very pleased to receive your note regarding the
studies in sex ratios related to work in this Department.
The

report presented to the Society of Biological Psychiatry
a preliminary report on “The Influence

is enclosed as well as

of the Sex of Hospitalized Schizophrenics
Dosage Levels of Neuroleptics“.

on

Therapeutic

There have been some additional data derived from a
predictive study in our clinic in which the sex of the
offspring from schizophrenic mothers was predicted before
childbirth. This study has been interrupted because the

students are in the military service. Because the data

both published and unpublished continues to be consistent,

that they prepare a report for the
hypothesis section of Lancet. As soon as they have
I have suggested

this completed

we

will send

you a copy.

I look forward to hearing more about your

studies.

Sincerely yours.
Fink. H.D.
Professor of Psychiatry

Max

Mszp

enc/

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July 5, i969
Dear John,
The holiday has given me a chance #0 cafoh up on my reading,
have Jusf rewraad your “A Perspecfive on Heroin". if is a fine
of tho hlsfory loading +0 our presenf
ariicie, and gives a clear imoga
inadequafa iogai sifuaiion. l was rominddd of an interview i had in
May ulfh fhe commiffea of fhe New York Academy of Medicine, ra~
assessing for the n'fh +ime the need for changes in the medical
ireaimenf of addicfion. i fold ihom of our oxperionces with mofhadone
and cyciozoclno, and when i oxprossod some onihuslasm for Those

and

i

pharmacoiogicai froafmonis was askod if

of fha commiffee membors
+heir roporf wilh some anxieiy.

The mean age
i

i

was

thought fhey worn

surely

75

years.

oihlcai.
i

awal+

reporf and if is mosf siraighf—forword.
be disrooordod by ovoryono in +he legal profession,
will romain an importanf raforenoo. Bro+man and Freedman

also read your

if will probably

AMA

bu? for us if
boih expressed approval also.

should hovo moved +o your

Deparimeniﬂ and
you have
in The siole oroorams. Sidnoy has found a new home and moved in lasl
nook (iii Ferry Sireof. Barringfoo, P.i.i” and is inking his family To
Soufh Africa for a vial? This monfh. My son, Jonathan, has nroduafad
high school and will aifond Colby College in Maﬁno this faii. Marfha
has enjoyed her Teaching in Gran? Neck vary much (quife a difforonoa from
fhe For? Washington school) and iooks forward +0 confinuing. For fhe
summer she is iaking ihe girls on +hoir firaf European irio, on a
i

By now, you

frusf That

you

new

wiil conflnuo to be as producllvo #horo as

minl~grand Tour.
.

Our own work is progressing slowly. The noihodono program
confinuos +0 be successful; cyciazocino also, although more care mus?
be oxercisod in frooflng the pafienfs. We have iookod a? the problem
of defoxifying Those pafienfs on mefhadono for more ihan 2 years, and
who may be making a good adjusfmeni. We fried To do this wiih The
agroemenf of iha subjecls and fho staff, and failed. We are now
lransforrlng pa+i9n+s from mo+hadone +0 cyclazooine (blind) and have
begun #0 decrease fhe cyclazocine douage. So far, no wlfhdrawai and
no

difficulties wifh anyone.

Naioxono confinuos to be a difficult problem. ifs duraflon
of action of 2.4 Gms/day is abouf 24 hours, buf fho company provides

��l\\\
‘

iOO mg labiols only~~ and have you over friad lo gal addicts To fake
24530 +ablofs a? once ? daily ? voluntarily ? i To gel around lhis
problem we are frying #0 develop a long acflng form of naioxbne, using
the principlo of embedding in a siiasfic vohiclo. We have asked NIMH
(Sidney Cohen) for a coniracl lo proceed in fhis developmanf, bu? he
seems less onihusiasfic Than we would liko.

Our principal effort for the presonf is in marijuana
research. Al Freedman has appoinfod Marfin Koelor fo our sfaff, and
he begins in mideuiy. On a recent visif fo Greece. l visifod
The inborafories of Konsianfln Miras~~ found +hom ever so much heifer

fine chomisfry faciliiios, oxcoilon?
nourophysioiogicai equipmonf (under +ho diroofion of Dr. Sioianis,
an NiH Trainee) and his own garden for growing cannabis. Or. eras
is an oxpari in lhe plan? grou+h, consliiuenfs. etc., and any projaci
fhof works wiin his holp, musl be boiler fhnn The Trash being published

Than

i

anliolpafod,

wi+h

foday. (Have you noon rho recon? article on driving comparing 2
clgafolfos of NiMH marijuana wifh 0.! mg% blood label alcohol 7)
Our desire is in formulate a niudy program in A+hens and Al and i
have proposed this lo NIMH (again, Sid Cohen) as a contract. Of
course, we are now anxious +0 undoriako some oxfonsivo, long term
siudies here To assess iho nourophynioiogic, behavioral and
psychologic offocfs of chronic marijuana use.

in oddifion fo fho narcoiic
EEG and even in schizophrenia
in
EST,
have.oon?inund sfndios
programs,
and anxlofy. Any chance of a vial? lho nox? limo you are in New York ?

if has
l

Ono

lost

marijuana hold in
Koch

been a busy year,

for

l offended a
special open session on
York in June under The dirooiion of Foorosonfaiivo
Brill, Forf, Cohen hold The MB nine and rhreo

commonl.
New

(U.S. Congress).

iowyorn fho ionnl nido. My first exposure To such sessoons. Lois of
name calling, arnumonln ad hominom, and mos? impressive, ihe ronoofod
plea for more sludlos. Evon fho young poopio asked for more dofa, and only
Honry Brill was ouro ina+ +ho drug was harmful. regardless of The daio.
if was a wild session, and Roproseniaflvo Koch expocfo +0 propose a
bill To 99+ up a sfudy cemmisnion on cannabis (like a Prnoidonils
Commission).
Knop up the good work, and many thanks for lho fine arfioioa.
have no? obfained permission for our sfudy of mofhodono in
psychosis, buf i? is loss imporfani now lhof i have other infarosis,
although if should bo done.
We

sflii

My

best regards lo Deena.
Sincerely yours,
Max

Fink,

M.D.

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                    <text>7".

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dolnvoh of

W‘v’wt‘vY-vw,

Y

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July 5, i969

r.‘

i-

r'1

"n"

Dear John,

—rv'."rz-.-.4-'

"H'an-ava'r

The holiday has given me a chance To catch up on my reading,
have Jud? ro-raad your ”A Porspecfiva on Heroin”. if is a fine
article, and gives a clear image of fho hisfory loading +0 our present
inadequafe legal siluafion. i was remindbd of an infervleu i had in
May wifh fho commllloo of fho New York Academy of Medicine, ro—
assessing for fhe n'fh limo The need for changes in The medical
lroafmen? of oddicflon. i iold Them of our experiences with methadone
and cyciazocine, and whon i oxprossad some enthusiasm for +hoso
pharmacological froaimonis was asked if i fhoughl They were ofhicai.
The mean age of fho commlfloe members was suroiy 75 yoors. i avail

and

«

"1‘01,

-.

_

é
"
wv

wuwnyna—n

-.w,.-r
,

.
iv

'

anrv-u-ur—mn-mu.

i

fhoir reporl wilh

some

anxiety.

also read your AMA reporr and if is mos? sfraighf—forwnrd.
will probably be disregarded by everyone in ihe legal profession,
bu? for us if will remain an imporfanf reference. Brofmon and Freedman
both expressed approval also.
i

l+

‘,r'

,

v

v"

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upmwwap

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mug-um

should have moved +0 your

new Doparimeni, and
be as produclivo there as you have
in The slain programs. Sidnoy has found a new home and moved in lasl
week (lil Ferry Slroof, Barringlon, R.i.i, and is raking his family lo
Soufh Africa for a visif fhls monlh. My son, Jonoihan, has graduofod
high school and will a++ond Colby Collage in Manna lhis fail. Mnrfha
has enjoyed her Teaching in Gran? Neck very much (quite a difference from
fhe For? Washingfon school) and looks forward lo continuing. For fho
summer she is faking The girls on fhoir firsf European frip, on a
By now, you

l

lrusf Thai

you

will continue

To

mini~grand Tour.

Our own work is progressing slowly. The molhodone program
confinuos lo be succossful; cyclazocino also, alfhough more care mus?
be exercised in froafing fho paflonfs. We havo looked of fhe problem
of dofoxifylng Those parienld on moihadono for more fhan 2 years, and
who may be making a good adjusfmeny. We Tried To do fhis ulfh The
agroemonl of fhe subjecls and fho sfoff, and failed. We aro now
fransforring pafienfs from methadone fo cyclazocino (blind) and have
begun to decrease the cyclazocino donage. So for, no wllhdrawai and

no

difficulfies wifh anyone.

zv-l

Naloxono confinues To be a difficult problem. ifs durallon
of aciion of 2.4 ems/day is about 24 hours, bu? lho company provides

11WWD'A'V"

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�v(

.

spun-um.

by.”

v'r

tablets onlyan and have you ever tried to get addicts to take
24530 tablets at once ? daily 7 voluntarily 7 7 To get around this
problem we are trying to develop a long acting form of naloxbne, using
the principle of embedding in a sliastic vehicle. We have asked NiMH
(Sidney Cohen) for a contract to proceed in this development, but he
seems less enthusiastic than we would like.
iOO mg

research.

Our

principal effort for the present is in marijuana

to our staff, and
visit to Greece, l visited
the laboratories of Konstantin Mirase- found them ever so much better
than
anticipated, with fine chemistry facilities, excellent
Al

he begins in

Freedman has appointed Martin Keeler

mid-July.

On

a

recent

i

neurophysiological equipment (under the direction of Dr. Stefanie,
an NIH trainee) and his own garden for growing cannabis. Dr. Miras
is an expert in the plant growth, constituents, etc., and any project
that works with his help, must be better than the trash being published
today. (Have you seen the recent article on driving comparing 2

cigarettes of

NlMH marijuana with 0.l mgz blood label alcohol ?)
desire is to formulate a study program in Athens and Al and
have proposed this to NlMH (again, Sid Cohen) as a contract. Of
course, we are now anxious to undertake some extensive, long term
studies here to assess the neurOphysioiogic, behavioral and

Our

l

psychologic

effects of chronic marijuana use.

it

has been a busy year, for in addition to the narcotic
have continued studies in ECT, EEG and even in schizophrenia
and anxiety. Any chance of a visit the next time you are in New York ?
program!,

i

One

last

comment.

i

attended

a

special open session

on

marijuana held in New York in June under the direction of Representative
Koch (U.S. Congress). Brlii, Fort, Cohen held the MD lids and three
lawyers the legal side. My first exposure to such sessoons. Lots of
name calling, arguments ad hominem, and most impressive, the repeated
plea for more studies. Even the young people asked for more data, and only
Henry Brill was sure that the drug was harmful, regardless of the data.
it was a wild session, and Representative Koch expects to propose a
bill to set up a study commission on cannabis (like a President's
Commission).

Keep up the good work, and many thanks for the fine articles.
have not obtained permission for our study of methadone in
psychosis, but it is less important now that l have other interests,

We

still

although

it

My

should be done.

best regards to Deena.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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1969

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardsley, New York

Dear Edgar.
would appreciate receiving an additional supply of
bottles of Tofranil 25 mg (100 capsules per bottle). A
We

10

lable is attached.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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