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                    <text>March

5,

1970

Dr. Anthony Kales

Department of Psychiatry

University of California Medical Center

Los Angeles,

California

90024

Dear Tony,
I

have

just returned

from

California

and in checking

my

notes find that I had promised to send you the enclosed information
with regard to our experience with doxepin.
I am also enclosing a sample protocol and interim report
of a compound which is now undergoing study. This information is,
of course. preliminary and I trust will be verified in the ongoing
study.
Come

visit

us when you are in

New

Yorki

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March

5, l970

5. Bureau of narcotics and Dangerous Drugs
l405 I Street. n.n.
Washington, 8.6. 20530
U.

Attention:

John Mayer

Bear Sir:

M

'
J14

I am writing to request 5 grams of recrystalized purified
heroin to continue our studies.

did receive l0 grams in Qctobor l969, but recently
we noted that the remaining supply has an acetic odor and has
become slightly yellowish. In checking old pharmacy books, we
find this to be a sign of deterioration which is ordinarily
prevented by keeping the supplies closely sealed and in the
dark. I regret that our supply has deteriorated. If purified
heroin is available at the Bureau. we would be grateful for
5 grams and will return our present supply for rocrystalization.
we

Thank you

for your cooperation.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

:4
at
.31..

.
)..ae_

1“

�</text>
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                    <text>March

5,

1970

ﬁr. Anthony Kales
Department of Psychiatry
University of California Medical Center
Los Angeles.

California

90024

Bear Tony.
1 have just returned from California and in checking my
notes find that I had promised to send you the enclosed information
with regard to our experience with doxepin.

I am also enclosing a sample protocol and interim report
of a compound which is now undergoing study. This information is.
of course, preliminary and I trust will be verified in the ongoing
study.
Come

visit

us when you are in new Yorkk

Sincerely yours,
Fink, M.D.
Professor of Fsychiatry

Max

MF:kp

�</text>
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                    <text>\r'v'

/~un

Wmav

Wad

March

5, 1970

Dr. Phillip Tannenbaum
Smith Klina and French Laboratories
lSOO Spring Garden Street

Philadelphia, Pennsylvania
Dear

Phil,

Enclosed are copies of the screening interview forms
subject permit used in our laboratory. I propose to
in the doxepin study.
these
use
and the

In addition copies of the other forms are enclosed

ymwianmﬂmn
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
811C.

for

�</text>
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                    <text>March

Dr.

J. J.

5,

1970

Lasky

national Institutes of Mental Health
lOAlO Barlow Building
5454 Misconsin Avenue
Chevy Chase. Maryland
Dear Jack.
I am pleased to enclose five copies of the report
"Lateralized EEG Changes after Unilateral and Bilateral
Electroconvulsive Therapy", as requested. In addition I
am also enclosing a preprint of a manual of convulsive
therapy which we have submitted to the APA for publication.
In presenting the principles of this treatment to our
residents, we found the usual texts to be incomplete and
we wrote this document as a teaching device.
My

best regards.
Sincerely yours,
Max

Fink, M.0.

Professor of Psychiatry

MF:kp
ENC.

�</text>
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              <elementText elementTextId="42832">
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              <elementText elementTextId="42833">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="103267">
                    <text>17

.
n—w,

Wm:

"er

.-.-n

wan»

.

"any“.

‘

t..-.‘-,_r.,..,....

if.

7.0

.ww,..w,_......__

__

~_m1-qu»w.—_,mn- .ﬂtwm—mwmmwwm. .d .m

-

mwwv

‘4‘W'V'~

March

.. -‘ ,, 7., ...u

6,

,

.

.

_

..-,

v

.7...

u» -

N

v

7

in

._-.

....

....- "r...

1970

Dr. G. F. Blane
Rackitt &amp; Sons
Hull , England
Dear Dr. Blane,
Tue

yanrs ago I wrctv to obtain information on

narcotic antageniats, particularly SOSO—M. it the recent
NRC meetings in Washington, a format associate, R. E. Lister,
mantioned that you had worked on a long~aeting narcatic but may
have discardad it because of its unusual length of action.
long acting narcotic with cross tolerance to opiates
useful adjunct in the treatmant of cplatm
dapendence; as would a long acting and potent narcotic antagonist.
A

would be a most

I am writing to raquast any infatuaticn that may be availahle
regarding patential human trials with either 0f these compounds.
Bava trials with 5050~M progressed to aageasments in man ? Is
there, indeed, a vary long acting analgaaic with cross toleranca
to opiates available ?

bafcre, we are actively involved in
of
these
aubstancea, and unuld appraciate the
trials
opportunity to extend theaa investigations in any masningful

human

As we wrote

way.

Thank you

far your assistance.
Sincerely yours.
Max

Pink, M.D.

Profesaor of Psychiatry

mf/

cc:

A. M. Freedman

,_

"y:-

,

.4 w

-

7-“

-.

‘

,

V...,

-

.....,

—

�</text>
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                  <elementText elementTextId="105838">
                    <text>March 7, 1970

ﬂoat Irena,

far the inquiry about a confatence on
phanathiazinas.
you knaw. my primary interest is in the
naurophysiology of compounds, and not their chemistry, so I have
not had munh of direct intereat to contributa.to warliar conferences.
Thank you
As

Heverthaless, I think such a eonferencc should be held, preferably in
1971 (late), in Europa. preferably in England whit: much of tha
work seams to be prngzeoaing rapidly.
As

is generally expariencad iuv

many

confurences. a

small wanting o£ aowse participants and an additional 30~50
observers anew; :0 he the moat nacful.

of the m&amp;ettng shauld decide on the participants,
9f the last wanting may ha the best to
lmadara
the
suraly
the
ralavant
internating topics.
assaaa

and

The them:

My

best regards.
Sincernly yours,
Max

Pink, M.D.

Professor of Psychiatry

mil

�</text>
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                    <text>‘-

mw-wmn-vu

:—

1,:—-.m-

«r»

n;

:45»;

:er

m.

-'V""P‘u'&lt;1"nz"ymu

Hr. Ha: Singar

March 7, 1970

Hudscn Institute
Cratenmen-Hudson, ﬂew York

Dear Mr. Singer,

I hnva read your interim report and apttndices with
interest, particularly since tha viawa are both novel and
engaging. A heroin diﬁttibution system, if faaaibla, may indeed
be a useful interim step in reducing the opiata abuae probleg.
An immediate reaction is raferanta to tha reputed failura of the
Britiih system, and your teviaw of that 'failure' is too superficial
to be convincing. I 3139 believe that our present climate will
not allaw such a system unlass it is encumbered by psychotherapy,
social tharapy, rehabilitatian, gtuup therapy. ggg,~ and this will
increase the costs markedly. Is this not nae of the handicaps of
the ﬂaw York State system, that it pays lip setvica to all systems.
much

having none

at its can i

I wauld immediately agree that tha heroin addiction
ptoblem~is not purely a medical problem, and that the solution
is not purely a madical oat. But that was also the status of the
syphilis, the tuberculasia and the leprosy problems. before medical
sclutiona wart definad. These medical solutions plus tha social
has had tht major impact in raducing the tragedies of these, now
curable, diaeaaea.

Since discussing our praposal for unloxona with you, we
have reviewei tha cyclazocint data, and find that the same approach
is feaaible for this drug as wall~~ that increasing the costs of
our proposal, since two drugs ought-to be studied. We are not
optimistic that either the ﬂaw York State nor the National Institute
of Mental Eaalth will provide fundu~~ both have said all the nice

things like the idea is excellent and tha awed is great. BUT . . .
differ in their ”BUT’S"? the results will be the same. we have
aleo made a presentation to the lawyers cf the Vera Institute, who
alao spoke highly at the ideas but "BUT«TED” the possibility of
They

tunding away.

�Max

Singer

0..HOODGIO.QiﬁtboblotOO‘OIOOIOOIOOOUOOMarch 7, 1970

principal question of your letter relates to the
of
channeling
opiate users to other substances if a concerted
governmental action inhibits the use of heroin. Indeed, that is
likely. Let us suppose that the heroin (opiate) use is severely
inhibited, and marijuana use increases markedly. So long as the
penalties for marijuana uoe remain the same, the results iutterms
of crime will be the same. But is it necessary to maintain the
fiction that marijuana in as deleterious as opiates ? I have
worked with both types of substances, and have read the literature
carefully. There is no relation in pharmacology or physiology
between the substances. One is Beverly toxic to the body, causing
extensive chemical chengeo that persist for weeks, months and
perhaps years; the other, minimal changes, of a transient nature.
Deaths do not occur with cannabis; they do with opiates. That is a
sufficient basis for me to consider the channeling of opiate users
to marijuana to be a social good, not evil, in the present climate
(provided the penalties were removed for marijuana use).
The

for the ’soft~drugs‘, here too, the pharmacology and
of
physiology
methedrine, amphetamine and the barbiturates are
sufficiently unique that the distinction from ooiatee is easy.
Addiction may occur, but deaths are lose common; dosages necessary
are very large for fatality; and while I am not so enthusiastic
about channeling to these drugs from opiates, I consider them
eo much less damaging, one addiction so difficult to achieve, that
e ‘uer' on opiates with a resultant increase in the abuse of
these drugs is still a useful 'wer’. (In the balance of nature,
the abuse of these drugs seems less commonly achievable than the
abuse of alcohol, and we have been able to live with that abuse
as a nation.)
As

-

You mey be pleased to know that the National Institute
of Mantel Health has looked upon our suggestion that a team of
atientiote be sent to Greece to study chronic (20»30 year) heehieh

users with

some

favor, and called to any that that contract will
effort to obtain some

be awarded effective June 1. This will be our
data on chronic cannabis abuse (use).

for the comments, the questions, and especially
for the preliminary reports with their novel (7daring?) suggestions.
Thank you

Sincerely yours,
Fink, M.D.
Profeaoor of Psychiatry

Max

mf/

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                    <text>March 7, 1970

near Irene,
Thank you for the inquiry about a coufaronce on
phenothiazines. As you know, my primary interest is in the I have
neurophysiology of compounds, and not their chemistry, so
not had much of direct interest to contributa.to anrliar conferences.

be hald, preferably in
ﬁeverthelaaa, I think such a confarencu should where
much of the
England
1971 (late), in Europe, preferably in
work seems to be progressing rapidly.
An is generally experioncad in many confarenccs, a
amall mnetjng of £O—60 participants and an additional 30~50
observers 333mg to he the most useful.
The theme of the meeting shoulﬁ deciée on the participants,
and suraly the lander: of tha last nesting may ha the best to
assess the relevant interesting tapicn.
My

best regards.
Sincerely years,
Max

Fink, M.D.

Professor af Psychiatry

mf/

�</text>
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                    <text>.

.

.u—

.

.

W,qrvuwmm

-v.-...,—n.

m‘:».‘rw .7.

,_ ., "Iaw-xw...u-r. 710-1.. ,, __‘3‘...._ “WVM“"m ~‘

--.-. 7‘ .n-w
...—.....(...-. ’.\w|»§l'l

:w

7-

w'vr-v

Yr .m- mmw

.

W..Mw~..—-v».n,w:«u-r

'lwv.

‘

:1

-

March 8, 1970

Dear Dr. Gaberg,
and I

Please call
will arrange to

through our program.

office on your arrival (212w369 7900)
have somecnu frcm hbe staff escort yau
my

You may be interested in the presentation by members
.of our department Thursday evening, March 12
at Gracia Square
Hospital (420 East 76 Street) at 8 p.m. A visit there may give

you an overview of the program and a progruas report on our present

arperitnces.

'

Sincerely yours,
Max

Fink, M.D.

Profeauor of Esychiatty
mf/

awn-w

.
w»

lwvvgﬁ‘w‘

.w-m

mm”,

�</text>
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                    <text>.

-.

n

p

,,.A,

‘7.‘.V‘.__....'.

"WWW-w

wr

“"me m..- «;“...._—..¢r.*-i.-~‘

"WVY~‘-1Wu-.~“n~‘ wuv

v.»

“:7

v

--~

....

ur-

~-—-w---—-—v—~v-/

-

-*—" '«

WW &gt;-

-

«~-

"~—-“ --‘

-

W‘WWﬂ/A

1--mwv~un&lt;mm

r
w

“.mw-

.3,"

'l'iih'Iv-Emrn.

r-n—

”arch 8, 1970

—£rFY'-4WW.

Muy

mung—raw

"vi.

Honorabla Lancer Wolff

Henna of Representatives
156A ﬁnin

Street

Port ﬂashington.

New

York

w-

V.”

us
v-

Bear Mr. whiff,

It

was kind of van to listen to my presentatian
regarding ER~137é3, now before the Public Health &amp; Walfara
Committee.

It

my experienca that our prasent laws and
police nuthoritigs havg inhibited zesaarch,
both in epiat¢s &amp;nd cannabis, and aontributaé matarially to our
preoant confusions and hysteria. Our labcratories, at the New

has baan

that: execution

by

York ﬁedical College, are davateé to obtaining some of the needed
informatien. Sons of the results are already publiohod; others
are preliminary; and other: are in the planning stagcs. I am
enclosing some matarial from our files that may he 0: interest.

y.»

am

»

-..

"WWI-mm

vu-

The

is

suggestion of holéing lagiatacivn hearinga in

a good suggestion, and I would be pleuaad to converata.
I an.cncloaing a list of suggestad witneaae; who would bu
scientifically. and perhnpa* politically interesting. With proper
preparation, tha quaationn of the effect. of tha law on therapy
and on research may bu elaborateé.
new Ybrk

Again,

my

thanks far your patience.

Sincerely youra,
ﬂax Fink, M.D.
Frofaasor a? Paychiatry

4

.

7-"lF'

«run—g

'1
.
.\

w&lt;-:~'?JY«;-—:

z-m—n

”warm-4'1.

..

'nm

mf/

�APPENDIX

Enclosed Documonts

I

Opiates and Antogoniata

l.

A

Program to
1970.

Restrict Opiate
Dated 2/3/70.

Dopondonca~rhe Urban Epidemic of

2. Antagonists in the Treatment of Opiate Dopondonce, 1969.
3. Intravenous Discotylmorphine (Heroin) in the Stndtlont of

Opiate Dependence.

1969.

6.
4. Basic Concepts and Use of Cyclazocino in the Treatment of

Narcotic Addiction, 1968.

5. Naloxono in Heroin Bopendeoco. 1968.

é. Cyalazoeine and Methadone in ﬂarcotic Addiction, 1967.
7. A Proposal for the Development of Long Acting Opiate Antagoniats,
1969.

v.
7:.

'rvv.-'¢

.aswn

-

V,....

.,,,

w'uﬁmemig.prx;‘V_—vku'wr.rw

Marijuana
8. Forspectives on Marijuana Research. 1968.
9. Preposal. Clinical Phatlnnology of Canoabio, 1969.
and Behabiorol Effects of Long Term Cannabis UseFoasibility Study, 1969.

10. Proposal,
A

‘ﬂ‘irre'wr:

‘Iltl‘lfﬁ'hz’wv

1:1"!

or

EEG

Poraonnol
11. Curriculum

vitae,

Max

Fink, H.D., Professor of Psychiatry

,ms'."

1:1".

I.’

Froedman, H.D., Professor of
Psychiatry anﬁ Chairman, Department of Psychiatry.

12. Curriculum

m",-

vitae, Alfred

mm".

List of Proposed Witneoses

APPENDIX 11
.f‘wiﬂv-

New
N'wwmrvz':

York Medical College

Alfred

3-”

Fink, M.D.
Arthur Zako, M.D.

"lﬂi’W-‘Iﬂ°£w*ﬁui-

New

York

State

'7.

m“:,‘fi‘i‘vv"

,
A".

rMAV-I

4n

[~0me

Froedman, H.D.

Max

1:19.,

so“

M.

Richard Brooms“, Fh. D.

my

”I

M.

Max

Singer, Hudson Institute

Vincont Dole, Rockofollor University

Brill, Pilgrim Stats ﬁosoital
Christopher Torrance, 8Y8 Narcotic Addiction Control

Henry

Comm.

�</text>
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              <elementText elementTextId="98162">
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                    <text>-.

-

,V,-

m

”mi—Viv”,

w.

Mltch 8, 1970
Dear Jon,

Yoatotduy. I met woth my local Congressman, Lasts:
Woiit, and discussed the Kongo bill transferring control of
rasoareh to the Justice Department. He was most oympathotic
and askod if the boat approach might not be to hold hoarings in
Raw York. on the basis of tho bill, to describe the present
efforto in drug reaoaroh.
This may have been a

'put~off'. but

he seemed

sincere

(are thoy not alwaya ?) and askod that I lend him some additional
data. I left the tootimony you gave mecwith him, and promised
to send additional.

material

list

Plooae add his name to the mailing

on the

bill:

of any direct

Hr. Lester Wolff, Coagrosnnln
156A Kain

Street

Port whohingtoo,
Many

Now

York

thanks.
Sincerely yours,
Max

P.5. I look forward to seoing you in

Fink,

ﬂow York

M.D.

Friday.

�</text>
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                    <text>March 9, 19l0

Dr. Joan Giambalvo
Smith, Kline &amp; French Laboratories
Philadelphia, Pa.
Dear Dr. Giambnlvo,

I have just read the latest newsletter of the BIA,
and noted the call for papers for the Septenbar meeting. I am
not sure that the work which we are now completing is of airect
may be useful for you to
interest to the Association, but

it

profile analysis of psychoactive drugs as a
classification procedure. As'you may recollect, we have been
active in defining drug specific EEG patterns in patients and in
normal valunteers, in an effort ta defina tha characteristics of
haw comrounds before thay have gone through artensiva and extensive
clinical trials. Tha work has had some interasting results. notably
in the classification of cyclazocine as an antidepressant, doxepin
as an antidepreasant, fantluraminc as a reﬁttiva anorexigenic, etc.
If there is a panel or symposium dedicated to novul
consider the

EEG

methods of assay of paychoactiva drugs;

or, with an emphasis on
the types of naval data nalyaen that may be useful in tha next
few years for psychopharamcology, perhaya you «bald consider

3

of

presentation by my associates and myself. on the general topic
“EEG Profile Analysis as a classification of Psychoactive Drugs".
Thank you

for your consideration.
Sincarely yours.
Max

rink,

H49.

Prcfaasor of Psychiatry

Mf/

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                    <text>March 9, 1970

Dr. Alice A. Lead:
Chief International Belerence Center

for Information

on

Psychotropic Drugs

Psychophermacology Research Branch
National Institute of Neural Health
5654 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Alice,

Following your suggeetion, Dr. Shapiro and I have edited
of our program review for the "Paychepharaecology
Bulletin”, and we trust it meets your standards. We would be
pleased to have the summary included in a review of ongoing
psychaphermagology programs.

the

summary

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Hatch 10, 1970
Dr. Turan

M.

1:11

Missouri Institute of Psychiatry
5400 Arnonal

Street

St. Louis, Missouri 63139

Dear Turan,

have never receivad reprints of the trifluperidol
paper. These are the only two requests I have received.
Would you care to answer these and perhaps send us a few?
Wu

Also,

this is the only sleep classification reprint

raquoat.thnt I have not answered.

Sincerely yours,
Max

Yink, M.D.

Professor of Psychiatry

Hszp

7A.“.

A};

A

‘

‘

‘\

‘

‘

'

�</text>
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                  <elementText elementTextId="105833">
                    <text>March 1. 1970

Dr. Ivan R. Reilaen, Ph. D.

Loma

Linda ﬁniversity

California

Dear Dr.

9235a

ﬁeilsen,
Thank you

for your inquiry abaut our

EEG

analygﬂa

taking the liberty of enclosing a copy of tha
letter I wrote today in answer to a similar inquiry, and trust
it will answer your initial questions.

syntam. I

am

If there are specific problems that you face in
the application$ at yaur canter, we wvuld be pleaseé t9 try to
£3313! in any practicabla way.
Sincerely yours,

Fink, H.D.
Professor of Paychiatry

Max

mf/

�</text>
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          <element elementId="50">
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              <elementText elementTextId="42714">
                <text>Correspondence to: Neilsen, Ivan R.</text>
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            </elementTextContainer>
          </element>
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              <elementText elementTextId="42722">
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--

«www- WWI-v“ mmvmh’cv

-

n—W—W w

»

.~—.

'WW... ._,.... _. m’-..‘

"""m"""“""!

‘

March

i0, i970

Dr. John Griffith
Department of Psychiatry

Vanderbilt University

Nashville, Tennessee
Dear Dr.

37203

Griffith:

i am pleased to invite your participation in a symposium
on "Pharmacological and Therapeutic Aspects of Amphetamine and
Hallucinogen Abuse“, at the forthcoming meeting of the GIMP in
Prague, during the period August li—l5, l970. We would like to
focus on a review of sociopsychiatric, biochomlcal and CNS
aspects of amphetamine abuse.

The emphasis is on ”abuse" tolerance and dependence, rather
than amphetamines as a model for schizophronia.

would like to ask you to prasent an overview of amphetamine
other sympathomimetic abuse in the United States, as wall as
your studies on the behavioral effects of amphetamine use. The
invited participants are listed in the enclosed abstract.
i

and

For your

if

you

presentation

you should allow 20—25

are able to participate,

i

minutes.

should be grateful for

return mail.
title
(l have delayed overly long in putting togothor this panel and

a
i

short abstract

(i50«ZOO words) by

about to be chastised.)

am

will

and a

Details of the meeting, as to hotels, location, gtgl.
return mail.

come by

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>W.

l0,

March

l970

Dr. John R. Smyfhles
Depatfmonf of Psychiatry

Unlverslfy of Edinburgh
Edinburgh l0, Scofland
Dear Dr. Smyfhlas:

have been commissioned by rho Program Commiffee of fhe
ClNP lo esfablish a panel on ”Pharmacological and Therapouflc
Aspects of Amphetamine and Hallucinogen Abuso” a? i The iorfhwould like
coming mooring in Prague - Angus? ll~l5, l970.
to focus fils program on The biochemical and pharmacological
aspocfs of amphetamine use and have asked Drs. Friedhoff,
l
have read
To parTlcipafe.
Griffith, Kielholz and Oswald
NRP
”Mode
of Acllon of
session on
your recon? summary of The
i
Psychofomimoflc Drugs“ and would like To invifo your parflcipaflon
in This CINP Symposium, asking That you summarize The NRP views
(porllcularly your own), as exempllflod by rho data on
amphofamlnes. The symposium will fake place befwoon Augusf ll-IS,
and i would allow 20—25 minutes for your preseniallon.
l

but

i

The ClNP does no? ordinarily provide funds for These meofings,
have been given a limited budgaf and i would propose to

divide if
As

i

have been delayed in puffing fogofher

and am abouf To be

absfracf (l50~200
Many

parllclpanfs according to need.

among The

chasiised,

words) by

Thanks and

l

may

air

i

this panel

ask that you sand

mail special

delivery.

hops That you will bo able To

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
HF:kp

me

an

parflcipafe.

�</text>
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                  <elementText elementTextId="105831">
                    <text>March

i0, l970

Dr. P. Kleiholz

Psychiairlsche Unlvsrsifniskllnik Basel

Wilhelm-Kisin-Sfrasso 27
4056 Basel, Swifzoriand
Dear Dr. Kielholz:
Some

offend.

i

of the

earlier suggesfed parflclpanfs

have sea?

The second round of

were unable +0

invifafldns.

Dr. John Griffifh accspfs, he will presen? his data on
amphefamlne abuse in The U.S. Your observafions, on drug abuse
in EurOpe, should be a logical accompaniment of this dais. either
as discussion or as a confrssllng (parallel?) reporl. Would you
please send me a fills and a lOO-iSO word abstracf, as soon as

if

pracflcabie?
As

soon as the various

immediafsiy.

invitees

have agread,

i

will write

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychialry
Mszp
one .

�</text>
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                    <text>March

l0, l9?!)

Dr. 0. Vlnar
Psych lafrlc Rcsoarch l ns‘ll ‘lu‘l’c
Prague 8 ~ Hohnlco

Czuchoslovakla
Dear Oldrlch,

l.

.Smposlum

paml for

ﬂu

I? has bwn dll‘flcul'l' fo assemble a sulfabla
symposlum on amphetamlm and halluclnogen abuse,

bu? l bellcw +ho aﬁached outline
look ln a few weeks. 2'53“ to
_2m

ls The way #ho program wlll
stilt provisional and {a not to

winked.

for flu publlcaflon of absfracl's, you may use ﬁlls
We
oul'llns for
panel, and as The formal abstracls arrlvo, l wlll
‘l'hom
sand
pow-hash 'l’o ym. lf may arrlvo ln flm. they should
be publlshed as wall; lf not ‘l'ho wawlow should do.
To allow

1’0 your earl lor suggesﬂon of a report on
abuse
by Angrls‘l‘ and Gershon, l have dlscussed ‘H’lIS
whommo
wl'lh Prcfonor Frladhofl, and Ms presanfa'rlon, whlch l prefer,
ulll cover such of fhls matorlal. The Angrlsf-Garshon report
may be lncludod la ﬂu fr» mulca‘l'lons.

ﬁlth referent»

2. Travel funds .
I

shall

la‘rfor (2/0/10) -

usoyup f0 $l.000.00 as suggoshd In your

I”: ll

ponlblo.

�«2-

Dr. Vinar

3.

Prqgram Cnumltfoo

March

l0,

W70

nofosll2/25/70).

Co~symposlaz

A

useful

mama,

principal of chairing these prosonfuflons.

and l agrao with the
The spocial IosSIOﬂs:

For elecfrophyslclagy: llll as co~chalrman; if you wish on
animal nauraphysloloaisf as ca~chairman, I would sugges? Dr. Hilfon
Klefzkln (Hallaca Labaraforlos. Crunbury. Hun Jarsoy 085l2).

Far clinical frials, Ennis or a reprasaniallvo of The Germanw
Swiss unifs should be considcrnd.
For

prediction, perhaps

van would wish sdmeone who uses

physiological predictors, as C. Shagass (Tampio Unlvorslfy) or

H. Eysenck (Mandalay).

For panolrallon 0i drugs in inn brain, Dr. John Rach (Oarfmoufh
College) or Steven Sharwood (Sfanfard Universliy).
As for llmillng prasantalians,
aufhor.
par

4.

You

ara dalng a fine Job.

its? of formal

sympcalum

i

in

would agree

Keap

l? upi

participants shoriiy.

i

will send 1h.

Sincaraly yours,
tam F‘nk’ M09.

Professor of Psychlafry

Mszp

cc: P. Kloiholz

ona prasenfailon

�</text>
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                    <text>March

l0, l970

Dr. William Tabor

A. H. Robins Company
i407 Cummings Drivo

Richmond, Virginia
Dear

Bill,

A review of our AHR~|900 laborafory data for changes in
blood glucose suggesfs fhal a hypoglycemic effect may occur
in some subjects, but our data is unimprossive. An absfracl
of fhis dafa is enclosed.

Blood glucose (88) measures during AHR~i900 and placebo

periods are available for

6

subjecis recaivlng

AHR~l900 in

400 mg. in L.F., J.M., A.G., and J.V., blood
dosages
in one measure each than during lho placebo
lower
glucose is
and
D.K.
in
period;
0.5., blood glucose remains of the some
in
blood
level.
L.E..
glucose is low bu? no preudrug oonlroi
AHR*l900 for 9 days only and The
received
is available. J.L.
no?
88
is
value
consfrucfive. Subjocf M.D. did not
single
have leafs while on N4R—l900 and R.L. and E.H. received placebo
only. When i asked Dr. Jones, our lnlernisl, she reiafed The
low 86 readings in 3 of The palienis lo dosages of l20 mg or
more of AHR-IQOO.
up To

available for shipmenl, as
ind
for
final
is our roporl, excopl
analyses from The Siomofric
To
do
awai?
these
complale fhe publicalion reporl.
Loborafory.
The ofher data on NlR~i9OO is

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mkap
911C

.

�</text>
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              <elementText elementTextId="42671">
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            <elementTextContainer>
              <elementText elementTextId="42672">
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          </element>
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                    <text>,_.,_.V,~,

A-

~.~

'tw-M'nw'r"

w-

March 11, 1970

on”

.43.

—

.m~.M-u,.*..a

51.5.,“

‘

Dr. Sholdon Gaylin
Depateucnt of Payohiotry

Grasslands anspital
Valhalla. How York

~J....,,._.V.v

Door Sheldon,

It

was kind of you

to

to amok time with no_
toﬁny. I was inorouaod with orogtaou that has boon made in tho
psychiatric facility, tor when I left tho hospital two yoato ago
after a oimilar visit, I was doprenood about the Collage moving
soond

to Hostchostor, but I fuel vary differently today.

trust that

I look forward to our continued collaboration and
some studios may ho dovolopod in Grasslaoau to augment

the ongoing program».

Stocorely yours,
Fink, M.n.
Professor of Psychiatry

Max
a!"

w":

.

,
"

"WI:

7

“a

“afar-.-

2-

31'

H

U

..

:n.-.:4.‘-:e';v,aw

v.

.-

49:13:74»,

.4

17,0]."Zl

,.

mf/

�</text>
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              <elementText elementTextId="42662">
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                    <text>March 12, 1970
Dear Mickey,

reprints,

Your
Some

sent to you).

nail continuaa ta
are ’crank'

cone 1n«~ moot requests are

letters, and some ara interesting

for

(and

The latest inane cf 81olag1cal Psychiatry has Carl
Ffeiffer’a response to your work, and his supvort is intaraating. He
is a very kuowledgable yharmacologist and has extensive experience.
313 snggast1ons are good as thay reflect the reapense of the

'establishmant' to your work.

I,

and a {aw 02 tha

staff, plan to

be in San Franciscc

far the B1elogical. Panchiatry Inﬂ APA.meet1ngs. Try to get a few
dawn off and 1010 the meetingo~~ ﬂay 8~10 for EioPsvch (E11ton
Hotel) and 1.135 £0: A?A.

,

’w-Wﬁ-rhu

;
"Nu-gm:

As for our untk—~ nothing new on lactate; I have given
to stanlay and get an amtiguous response (Write to
message
yaur
him diractly and his cultural heritage will elicit an answer [his
wife wag just delivered of a fine seal); and Dick aaams to hava been

unable to negotiate the member system to taut the penicillamine
hypothea1s. But he is busv u1th othar t111ngs, including a fine

theory.1ar the testing of an antagonist to alcoholism; and his
is progressing well, albeit slowly. Ha took his fitst spinal
fluid sample today and is on h1a way to test thc cutacholamine
and acetylcheline hypotheses of ECT.
ECT

The.achool is planning to push its move ta Westchescet
rapidly;-ve have just appointed the new superintendent of the
Kirby Boapital (1/3 Manhattan State) to an: ataff; our aontract
for a study in Athens has been approvad (marijuana, of coursa); and
lots more. It W111 keep until May. Plan to have dinner with us.
Keep up

the good work.

Sincarely,

�</text>
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                    <text>March 12, 1970

Dr. Svetislav Vonov. 3.9.

Upjohn Company
Kalamazoo, Michigan
Dear Dr. Vanov,

Both the afternoons of April 20 or 21 are {too for
your visit to those laboratories to discuss U~28,774. I look forward
to roodiug the material that you have sent. and ohould be able to
provido a protocol to mac: your toquironontu.

Please call my office
confirm the date best for you.
Room

62.

The

office is at

S

(212—369 7900, x246,248)

to

East 102 Stroot, 8th floor,

Sincerely yours,
Max

fink,

M.D.

Profoasor of Psychiatry

m?!

»

_

'_

y‘nrnmhuyg-zmww:

W3V'

”TIEY’I‘".

�</text>
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                    <text>March 12, 1970
Dear Bob,

It

last wrote. The
studies are still exciting papular interest, with many reprint
has bean sumo weeks since you

requests continuing to coma in. There are also kooky
some of which I have sent on to Mickey.

letters,

I am enclosing Carl Ffoiffer's lotto: to you-» he aunt
it to the Biological Psychiatry, but it is meant for both of you.
As he in an oxpotioncod investigator with an extensive exporieoco
in schizophrenia, I enjoyoé his report ané on sure you will also.
you

Surely, this work should be continued, and I hope that

will plan to continue as soon as this chore in over.

Will you be able to come to San Pranoioco ? If so, the
Biological Psychiatry meetings are May 8~10 at the San Francisco
Hilton. I hope that you will be able to join us for dinnod sumo

evening.

.

.

Stanley has some of your work dooen- I asked in response
to Mickey a request, but it is unclear what has to be done next.
I suggested you or Mickey write directly to him. ané I am sure

he

will answer.

_

There is much that is going on here~- tho College is
increasing the paoo of its discussions of the move to Westcheoter;
our affiliation with Kirby Hospital (1/3 Manhattan 3toto) has
progressed to the joint appointmont of the new director (a former
student of mtno, Mort Woohoproao); and our contract for studies
in Athens has boon approved.
Stay out of miaohiof.

Sincerely yours,'

�</text>
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                  <elementText elementTextId="103257">
                    <text>Maren 12, 1970
Dr. Nathan 3. Kline
Rockland State Eospital
Orangaburg, Raw York
Dear Hate,
The

rules of the

ACRP

are probably too

I have already agreed to sponsor one of Dr.

strict, for

Itil's

co~

workers for this year. I think that Br. Schulta should
be a member and will be glad to second his nomination if

I had tnother vote.

Sincerely yours,

Professor of ?sydhiatry
Hszp

�</text>
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                    <text>March 12, 1970

Honorable Lester Wolff

House of Representativun
156A Main

Street

Fort Washington,

New

York

Dear Mr. wolff:

Separately I havc tent you a packagn of material describing
work
in opiate dependence and marijuana, in conjunction
our
with my request that H.R. 13743 not be approved in its proscnt
form. As an example of the impact of Federal Laws on research,
I am enclosing a copy of a two pogo letter which I have just
received from NINE in response to my requeot for an additional
supply of marijuana to continue our research program.

While none of the requirements are difficult to meat,
each onc has an inhibiting influence. Even NINE has the
misfortune of appointing administrators of limited capacity.
Thank you

for your interest.
Sincorcly yours,
Max

Fink,

M.D.

Protozoa: of Psychiatry

�</text>
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                    <text>March [3, |97O

Dr. 0. Vlnar

Psychlafrlc Research Insflfufe
Prague 8 Bohnlca
Czechoslovakia
—

Dear Oldrlch,

Enclosed ts an absfracf from Brs. Friedhoff and Schwelfzer.
I
am also enclosing an absfracf from Professor Renner?
which I recalved foday. This absfracf does no? seem appitcable
to +he symposium on halluctnogens and I am sending If on +0 you

for procasstng.

S!ncere|y yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF3kp

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                    <text>a

vv—w-u

«my—mum ~—- v—wpumw—ww.

V” qr... “r4m1"¢&lt;)lr'leA-'Wr.“wA w

mum.

.-

“an,“ _. .71 awn-was.

March
Mr.

w

-

N's-n-vW-‘wvv

an. 1,." w.

.

,

e

V

___...., -

an. ”a-..“ w...“ .v. w_,w .v-..,.1_-v _. a...“ ,7 .7

l3, I970

Jack Bernsteln

Boston State Hospital
Boston, Massachusetts 02l24
Dear Mr. Bernsteln:

Separately we are returnlng the sample tape. As Mr. lrwln
dlscussed wlth you. your tape recorder ls fully competable wlth
ours, except that there may be some I problem In the footage counter.
would appreclate your sendlng
To obvlate any footage dlfflculty,
a paper playback, marked In footage wlth the next tape so that
we can compare the footage meters.
A

EEG

problem ls the proper settlng of the galns of the
For those channels recorded on tape, please set the

crltlcal

machlne.

ampllfler so that

50 uv

'

l4

mm

pen

deflectlon.

suggest that as soon as you have some EEG material from
a subject on tape that you send It and the playback for us to
check agaln.
May

I

am also encloslng the output of the sectlon on zen medltatlon.
Because the sectlons are short It ls dlfflcult to Interpret. Epochs
ll-lB show llttle change from the llstlng, but epochs l9-27 may be
dlfterent,‘13g;, a decrease ln amplltude and In verlablllty, an
lncrease ln average frequency and ln fast frequencles, wlth a
decrease ln delta.
I

Slncerely yours.
may

.

w...

":41"

own-WW}

w-rmqvwv

s-

1v‘-Inr‘

Max

Flnk,

M.D.

Professor of Psychlatry
Mszp

Wmv

V

,

,,

,

�</text>
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                    <text>March 14. 1970

Dr. Allen Hirsky
Boston n.1versity $chool of Medicine
Boston, Massachusetts
Hoar Allcno,

the publisher of the Clinical Eondbook of‘Pbychapharmuoology
to write a testimonial, and I was about to do so without
reading (the cxcollenco of the cast who sufficient), but was
intercoteﬂ in your chaptor. Alas. you must have doshod it of! in
your early period, for surely tho viowa are not yours today. Or,
are they 2
asked

me

The out of animal EEG data and single dosages leads to
such atntcmcoto on " Fig. 3 and Fig. 4 illustrate tho relatively
simplo affect [sic] that chlorpromnzino has on the EEG, as compared
with the variety of effects seen over time with cccobarbital”.
Chlorpromnzine is no more slmplo in its EEG affects and no dose 3
time sonaitivo as aecobarbital.
'

1..

"It is not the case, however, that there will always
EEG effects of drugs."

"."TYW‘IZ‘C'

‘4'.“

.1

"’wa'i‘i-E’“

'54.

TILL

573917

277317.13

"9

be concordancc between the behavioral and

Rotorooco to Wiklor emphasizes again tho fact that the Ems may
not ha related to motor bohavior, especially in dumb beasts. The
aissciiotion seen by Uikler and emphasized by Bradley is not the
tuna in man, for heaviors that may be relevant to psychiatry, and
this statement in a clinical volume presents the wrong vicw of

human

data.

’

‘

“

ﬁ‘Ji“

~&gt;Wm=w-;w~

"3‘93""1":

The selection of Tables 1 and 2 increases this erroneous
View. Bradley's ‘oxcited’.'drowsy' and ‘oormcl' reflect no behavioril
moosurement or tank, but simple observation of motor behavior.
Do you roally believe that 'excitod' after LSd and after atropine

are the

some [even

'f’marﬁ'

.t‘té.‘

:;'~'t:'.'v_r»

'

:-,

:.

;

.mvﬁl‘vﬂczﬂ’f‘

mammal:

;:

57'FTSITV5“;W€IE‘K:

3,12.“

.91»

hold for

Table

sumo

2

in the unspecified species deccribed'by Bradley]

is

dose dependent, and thcso

doses. but not for others.

relationships

may

1

�Mirsky

O

O

I

C

O

I

O

D

O

D

I

I

O

C

O

O

I

O

O

O

O

O

O

Page

2

There is more, but this should be enough to show where
I disagree. I horn quoted your work in animals, as you know,
as examples of what can be learned by careful EEG analyses plus caroful
and relevant behavioral measurements. How can you quote Bradley's
1957 data in 1970. after your own work 1 Or, even after our
review, that is, Bradley's and mine, of 1958 (Antioholinorgic Drugs
and Brain Functions in Animals and Man, volume 28, Progress in
Brain Roosarch,_£1oovier )

?

;

Perhaps, we should review the problem of EEG and behavior
anew. Dissociation or Association are in the eye of the beholder,
but presenting the viow of dissociation. based on animal data [without
specifying spacioo l] in a volume devoted to man (CLINICAL HANDBOOK .'.]
should be done cautiously and humbly, not carelessly, for the students
for whom.the volume is intondod, will he unablo to assess the
correctness or incorrectnoss of the text, and may be misled.
my

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

mf/

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                    <text>:1

inwnv-«marﬁ

1-va

“run.

r

bin-ah 15, 1970

Hr. David ﬁgyden
81310! Editor

sextant Hausa
Raw fork Clay
Ema: Mr. ﬁaydﬁn,

I have read the valunu, €2in£aal ﬁandbaok af‘Psyaho~
phanmaaalagy, adxtad by Diwunaia aaﬁ shudar, with grant interact.In samurai, tha aaaciena are well written, nuthazitativu sné typrsoant
the grcvmillng apinion a! ch: leﬁdurt xn psychaphuraaaolcuy as
unually oxyraaaed in mattingw and writinga.
r

mmwe'rm‘mw:

vv

¥her¢ is and seating. hgwavur. whiah in proacncad
to gently as to dqatwuy ch; vulva a: aha valumn for am. Enfartunately,
I tn partieulatly intcroqtﬁé in and identiftaa with neurophysiology
of psychoactivu ﬁrugg. Tbs aaatian by Miruky is too poo! to be
acccytqblc to m¢, and my gppravnl of tha rust of the Voluma
(which I mania gladly give) may ha migtakmn as my apprawal for
this cactiun as well.

‘1‘3N‘R-

Thank yam

warm-r3157,-

publieacian.

my

{at the opportunity ta cea thia

Ea»: wiuhna ﬁat

its

Vulumn

hater:

aaeoptaaes. ﬁespiae 1:9 flaw.

‘1
~

V

Kinccraly yearn,

-mvlm"éwsiwvt".=w¢

.9123

Fink, H.n.
Profaaaor at Psydhintxy

Max

W'Eemmxw

mywsm

W552“.

4-.

aura”

m

‘
1-

~mwm

mmwyﬁmrm

uf/

�</text>
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                    <text>March 14, 1970

Dineecio
Director of Psvchophnrmacology
Boston State Hospital
Boston, Massachusetts
Dr.

A1

Dear A1,

It was kind of you to recommend that I review your
Handbook oj’PwyohopharmaooZogy. I find
an excellent

Clinical
it
representation of prevailing opinions, and I am confident it
will serve a most useful purpose. I particularly enjoyed the
section by Sy Fisher, whose principles delighted me; and the
reviews by Klerman, Cole, Kornetsky, Friend and Ching~Piao.

interest to

section

by Allen Mirsky, holever, of particular
is out of keeping with the rest of the volume. Hie
animal data in a clinical volume allows the presentation

The

me,

emphasis on
of views that are irrelevant (or the least) and incorrect for men.

that he knows better.
this material is included. A
I

know

enclosed.

and I am at a loss to understand why
copy of my comments to him are

Since neurophysiology represents

my

principal

identification in this volume, I hesitate to recommend the
whole (since I disagree strongly with this part), lost my
approval be misinterpreted.

Alas. for the rest is well worthy of support.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>~w

March

l7, l970

Dr. Charles Shagass

Easfern Pennsylvania Psychlafrlc lnsflfufe

Henry Ave.

&amp;

Abboffsford Road

Philadelphia, Pennsylvania
Dear

Charlie,
Enclosed is a

ieffer

from Dexfer Ballard

consideraflon of the Membership

Commi++ee.

Sincerely yours,
Max

Fink, M.D.

Secretary

MF:kp
BBC.

for your

�</text>
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                    <text>"In—1m m.

2“,." . .,.»...m.\.....Mum-4...”....

-,,.-

_ ,

rrwuw-wwu-‘mmr-rm .- .—.._.....—_.w....

v.1,

r

,

.

iv"...

..

..~

ﬂ...

—_

-MW ”rm“. 2...“...W—W

..,,.

.7. ,.- N... 7....”

u 7.. w.

w

.y-.-

W.

v-wrﬁrm-

March

l7, l970

--

wvrw-w-z-L

To Whom

it

'»—w-

i
,.

.mg-wr—mﬂ.

am

May

Concern:

writing this letter in support of the application of

Mr. Peter lrwln for admission to medical school. i heartily
recommend his admission, believing that he would make a knowl»

edgeable contribution

m

sum-guw.

‘n-JN

e

'

”WWW

“Wu

Nam

hava known Mr. lrwin since January l968 when he Joined
my staff as a research fellow in lieu of military duty. He is
a registered conscientious objector. During the past 26 months
he has prograsslvely assumed greater and greater responsibility
in my research programs, evaluating psychoactive drugs in normal
voluntears. He has exhibited abllltias in interviewing and assessing
drug effects. both gross and subtle; he has developed a facility
in reading and analyzing the human electroencephalogram for
research purposes; he is capable of handling electronic equipment, including an lBM l800 computer; and most importantly, has
l

an

szwmwnwv

to medical science.

ability to relate to
He

is

a

members

of

«um—tr.”

staff.

personable young man, friendly and well liked.

At

has assumed responsibility
assertive.
with
and
good Judgment and for
sxoacitas
responsibility
gladly
confidential matters, with discretion.
times he is brash and

«an.

my

He

His uncle, Professor Samuel lrwin, of the University of
is a well known research sciantlst in psychopharmacoiogy.
His uncle's stimulation led to his working in this laboratory and
he has developed an enthusiasm for psychiatric research which is
commendable and which i have encouraged.
Oregon,

Wrpr'm—W.Y

pleased to racommand his admission for medical training
despite the apparent lack of basic science interest during his
early college career.
i

ra—u-

2

am

Sincerely yours,
Wﬁ'wi'l'm‘w,mﬂ_lwlw

Max

Fink, M.D.

Professor of Psychiatry
Mszp
.

..

�</text>
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              <elementText elementTextId="42543">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="105824">
                    <text>l 3 1 1 11

.w-

~11

,

-n‘:'~'r-v

“r

uj'v

.

"7mm ~—..w.w—-—..—

VFW

,

v—"r-I—I—u

wwmmrF-m-V

n

mjw—W-._.m._v.wﬁ7-..."

----_....-mw-.ww.-w_1

V

m,7.....-A-..A-‘._._...._v--,-_

“Hwy",w,“

March

l7, I970

Dr. Wllilam Tabor
A. H. Robins Company
I407 Cummings Drive

Richmond 20,

Dear

Virginia

Bill,
if seems rldlcuious fo val? for fhe ﬁlamefric

revtew of

Laborafory

Separafoly, I am sending you Two books
confalnlnq fho date of AHR-IQOO - your sfudy voiume which
Includes our summaries, data sheafs and +ho dafa evaluation,
and our laborafory dafa output.
AHR-IQOO.

As

soon as The Biomefrlc Laborafory lnformaflon ls
I will
ship I? #0 you and wrifo a publicaflon

My

has? regards.

available.
report.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychtafry
Mszp

�</text>
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                    <text>!

V

i

t

Marth 18, 1970
Dr. 0. Vine:

Psychiatric Research Institute

Prague 8 - Bohnice
Czechoslovakia
Beer Oldrich.

Enclosed is the abstract from Dr. John Griffith
will present in the ysnel "Pharmacological and Therapeutic
Aspects of Amphetamine and Hallucinogen Abuse".

who

John Davis has agreed to discuss the Friedhoff paper
in our symposium. He has written to me asking whether he
could present a full report of his work in the free communications
on amphetamines. Enclosed is his abstract. If the abstract cannot
be published with the free communications, I would be pleased
to have it published with the abstracts of our panel.

separate abstract was sent to me by Professor N. B. Essman,
asked that this be included in the free communications. If
space and time permit, his work is among the best in the v.5.
and I believe it would be interesting to our eenbers.
A

who

Sincerely yours,
ﬁe: Fink, M.D.
Professor of Psychictry
HF:kp

encs .
v

.

Firm-aw"

.

�</text>
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                    <text>March 18, 1970

Dr. Henry

Brill

Pilgrim State Hospital

Box 22
West Brentwood, New York 11717

Dear Henry.
Thank you very much

in the Institute
on September 22.

on

for your invitation to participate

Hospital and

Community

Psychiatry Service

I would be pleased to take part subject

only to the reservation that my holiday plans are not yet
firm and I may be away during the month of September. In
that event, I would like to feel free to ask either of my
associates, Hrs. Arthur Inks or Richard Roenick, to participate,
since both have the most clinical experience with methadone.
Depending on how broad a spectrum you would wish to
present, I think the antagonists should he discussed as a
model and the problems compared to the problems for methadone
maintenance. I think one should also try to present the
methadone treatment in the 9:83pective of other biological

therapies, including heroin maintenance.
I look forward

to hearing

from you.

Sincorely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�March 18. 1970
Dr. Jose

M.

Musacchio

University Medical Cantor
Department of Pharmacology

New York

550

New

First

York,

Avenue
York 10016

New

Dear Dr. ﬁnsacchio:
I

am

pleased to participate in the pharmacology teaching
to discuss the ”Clinical Pharmacology of

program and propose

Oplote Dependence". I would like to present our approach to
the treatment of heroin addiction, comparing the pharmacology
of heroin maintenance, methadone maintenance, and cyclazocino
and MI oxone antagonism

.

wish to bring some
would be useful, however, not
I

may

Thank you

2 x 2

slides

and a smell

essential.

for your invitation.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry
(Soc. Sec.

Mszp

#

016~18-2080)

projector

�</text>
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                    <text>March 18, 1970

Dr. Enoch Galloway

Chief of Research

Department of Mental Hygiene

The Langley

Porter Neuropsydhietric Institute

401 Parnassus Avenue
Sen Frencisco, California 94122

Dear Roch,
and I look forward to the program
Rework.
I am delighted to discuss the
you have set up in
neurophysiology of biological treatments and would be glad
to cover convulsive therlpy end/or drug therapy. It seems
November 7

is clear

if

Charlie discusses the changes that occur in
might be interesting to describe the changes
it
that occur with treatment and while we may not come to any
conclusions, the comparison msy he of interest to all of us.

to me that
psychoses,

the extent that it is relevant, I will include the
changes in the sleep EEG following these treatments, although
I hove not done the work myself.
To

My

thanks for your

invitation.
sincerely yours,
Max

Pink,

{‘50:}.

Professor of Psychiatry

�</text>
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                    <text>w—vn-Lmvz

"W

March 19, 1970
Mr. Stephen Miller
WCBssﬁditorial Office
51 West 52nd

New

York,

New

Street

York 10019

Dear Mr. Miller:
am enclosing two sets of
narcotic antagonists and our proposal for
and the other on the proposed drug abuse

In response to your request I

information, one
a long

acting

legislation.
tried for

be

on

form;

preposal for a long acting naloxone should
a long acting cyclazocine as well.
The

With regard to legislation, 5 3246 has been passed Err
the Senate and now appears before the House Public Health and
Welfare Subcommittee of the Interstate and Foreign Commerce
The new bill before the Senate, 8 3562.
Committee as ”-13743.
the
response of a few Senators to criticisms of the
represents
administration bill.
My testimony and that of Professor Daniel
of Chicago are enclosed.

X.

Freedman

r

I

A-m—

1|“er

trust this iiformation is useful.

"r"

Sincerely yours,

&lt;

Max

Fink,

M.D.

Professor of Psychiatry

Mszp
one .

.

�</text>
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                    <text>vv.‘.“‘l

-vw—~x'wl|‘i|"'-"1'~ﬁ~Vr

"ww:

March 19, 1970

|p';ﬂva-Tvrn

Br. Allen P. gorger
vagwwra.w--—ku.w

Chas.

Pfizer

ﬁ

Co.

Groton, Connecticut
”-

'x-u

.

Dear Allen,
As you will recall, Hrs. Simeon and Nikolovski
interested in treating the failures of the doxepin~

became

chlordiazepoxidc study (as well as the doxepin successes
after 8 weeks) with a ”stander “ drug. They selected
thiothixene and the enclosed short protocol is the
modification of the doxepin-chlordiazepoxide study that
they used. Also, enclosed is the summary of their
observations.
Separately I am sending you the case summaries, and copies
of the various NIHH study forms - personal data inventory, drug
study resume, brief psychiatric rating scale. clinical global
impression and treatment emergent symptom scales. The Biometric
Laboratory hes analyzed this data and their report with a set
of the data card outputs are enclosed.
The

v—w

-'

«saw-‘2‘"rr'wrnmzw

laboratory data

was analyzed by

their output is also enclosed.
Based on this information,

we

Biodata, Inc. and

have proposed a more

study. s protocol of which has been sent to you.

I onticioate submitting the
JOurnaZ of’th Drugs and I will

answer.

report of this pilot study to the
notify you as soon as I have an

“NI—Www'!‘

Again,

my

thanks for your cooperation.

rT

'rIir-.4i

definitive

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="103248">
                    <text>~— -.v-;——vv--_~u~

Wuwww.wwn——.W.T— m—

mw

- «"I’w‘vwv‘w... «.m..- .._

.i-

.

.7

,

v7.7".

m”

r—- ___, ‘_.._m-——r——W-—-—rv—-—v—--—vww—w

"w.

a—
—

March

~—

i9, l970

Dr. Allen P. Borger
Chas. Pfizer &amp; Co.
Gro‘ron , Connecficu'l'
Dear Alien,
,
w“:

.
~

.‘w

.~

-

.wmwewvwmwfw.»

3.,ww-wwnww

'—

.—

Separately i am sending you The complefed dafa sheets
of +he doxepin—chlordiazepoxide sfudy. You have already
received the Biometric Laborafory analyses of this dafa.
i am enclosing the card ouT-pufs as
supplied by fhe Biometric
Laboralory for fhe use of your sfaficlans.
in addifion

Biodala, inc.

i

am

enclosing a laborafory dafa oufpuf from

Enclosed wifh This ioffor is a more complete final reporf.
This includes some fables no? submiflad To Currenf Therapeufic
Epseargh, Thu? report has been accepted for fheir April issue.

if

mifflwm‘”

has boon a pleasure working wifh you.

Sincorely yours,
.--.

Max

v

"3‘

,...

van.»

V-i.v

‘40.“.

v-

Fink,

M.D.

Professor of Psychiatry

aer‘I-err-ra'w-y—

MF:kp

�</text>
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                    <text>mm"?

March 20, 1970

Dr. Edgar Grunweldt
Geigy Pharmaceuticals

Ardsley,

New

York

Dear Ed,

Enclosed is our report, “Ketiprauine in the Therapy of
Depression in Outpatients”. Separately, I am sending case
summaries: cepies of all forms; the NIMH Biometric Laboratory

data analyses and duplicates of their output cards; and the
Biodata clinical laboratory outputs.

I regret the delay in completing this study and wish to
thank you for your patience and cooperation.
we would like to submit the report for publication in
the Journal of yew Drugs, if you have no objections. To do
so, I would appreciate a list of published references on
ketipramine, and as many of the reprints as you hay have
available, so that the study can be put in the proper context.

Again,

my

thanks.
Sincerely yours,
“or Pink, 3.0.
Professor of Psychiatry

Mkap
911C.

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                    <text>.m_ww.m

mmwm'wm

n—wrwaw

4‘:

«2-—

March 20, 1970
Mr. Max

Singer, Prosident

Hudson Institute
Quaker Ridge Road
Crotcn—on~Hudson,

New

York 10520

Dear Mr. Singer:
ouch has happened sinco I received your interesting letter
of notch 12. I appeared beforo Senators Hughes and Javits in
support of a proposed bill (S~3562) to establish a division of HEW
dedicated to a national effort in treating and studying drug
depondonce. Mr. Javita became interested in antagonists and
when

his office called

NINE, they were told that our
was rejected.

contract for a long acting naloxone

is to your questions.

present Facts or

dogma; but

unsolicited

Most are unanswerable according to
here are some tries.

”Craving“ after detoxification as a metaphor, “there is
nothing in his body which one can hope to influence”: There is

that tissue cells

change when exposed to opiates, and
a single exposure, are long lasting.
When animals are exposed to an opiate days or weeks after the
initial exposure, their response (however measured) is significantly
altered from the response of unexposed animals. Thus, opiates are a
some evidence

that

such changes, even

after

potent signal and ono~trial [or fow~trial1 learning occurs ~ with
consolidation of “learned“ behavior very rapid and persistent. Such
evidence supports the view of opiate dependence as a biological
How to induce “unloarning” or forgetting is our problem.
problem.
We need means to enable selective forgetting (g;g;, in such diverse
illnesses an phobias, allergies. penicillin and rﬁ sensitivity,
935;), and the “cure” of opiate dependence may be viewed in this
framework.
By the dictionary, it may not be a ”medical“ problem,
but it is a biologic, not a aociologic, problem.

�nw-w-v—IVWW

»V..-———-.wW——n..—..w

‘W~WW WWW—“WW""a... ,_
.

Mr.

w. .

.

,7 Wwe...

1..

pm_—w.wwmmm. Maw—.wm.

..

.

-2-

Singer

March 20, 1970

The problem with methadone maintenance (and

2

’

.

heroin maintenance)

is that these agents consolidate learning. A principal hone of
treatment by antagonists is that they may serve to reduce opiate
"memories.”

.

H

of ldroin Addiction: A spontaneous cure reflects
some subjects to resist tissue demands for opiates
fer sufficiently long periods to reduce tissue changes by disuse
atrophy. Whether the drive to withstand tissue demands is socially
determined (as in asceticism), physically (as in incarceration) or
biologically (antagonists) may be irrelevant to the outcome of
discontinued addiction. RAV is an interesting term that needs
clearer definition.
The Nature

the ability of

._m.ww_,m,uus

WV.

“Wu—A

.«

Hwy

«r
-.

..v7-—.r‘—vr”mMW-Irmv-——M

Heroin Use and Disease: Some interesting ideas, I have responded
with marginal notes, agreeing with most, and disagreeing with some.
1. A reason for reducing a habit may be expense and strain, but
this sounds like a rationalization. Perhaps, a reduction in drive
for opiates occurs because of hormonal changes (stress, age) or after
an illness which may alter tissue responsiveness.
2.

Like with other addictions, as alcohol, tobacco or barbiturates,
seems necessary to assure availability of the drugs.

social participation
shawl-

cw,-

:wgq.;n~v

Perhaps contagion is re—enforced in opiates because users know
To assure an adequate supnly, they wish to increase their
connections, so that if one connection is disrupted, others will be
available to sustain the dependence.
3.

it is illegal,

”pr

w—

.,

4.

Theoretically balanced, but is there any evidence?
had apple in the barrel analogy is applicable.

5.

Surely, [repeated] exposure to opiates is the necessary

likely, the
,wvwwrwrwmwl

and

sufficient causal factor.
These are

.‘y

”.7,”

More

my

responses.

Perhaps I

am

over-emphasizing the

biological bases of addiction, but this model seems to provide a
better theoretical framework for the study of your questions than
sociologic or psychologic theories.
I look forward

to your recommendations

- which I hope will
some other techniques

balance the psycho-mania and methadone-mania with
for study.
Sincerely yours,
rwﬁwww

:‘zax

Fink ’

:51. D

a

Professor of Psychiatry

Mszp

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                    <text>Herch 21, 1970

..

A.

'Wr‘n:rv‘m.rz“r‘

Prof. Neil Burch
Texas Research
Houston. Texas

Institute of Medical Sciences

,.~,.v.m.-uww-,W~v;w;

Dear

Neil,

m.”-

-.—v

Iu'f'a‘rI/I-

W'ﬂ-m‘wvwlr“

v‘n‘

m-A

uwwu

-

x

‘mmzm-w

‘-‘DWVP'LV¢

Recently, I read of your repeat, Outline Classification
of'Pbegraph Responses, and I am writing to ask if you can rake
a copy available, or the citation.
continue to use period analysis and find it
useful. Is anyone else using it for EEG ? I keep reading about
power spectra for everything; and when that is not used, then
We

averaging

will
grateful if

Abrams
"Jn'r‘lw'nt-

.--_—-

a"

13

the technique of choice.

of my staff, Dre. Jovan Simeon and Richard
be at the VA meetings next month, and I would be
you would arrange for one of your residents to show them
Two

around; they are interested in seeing other programs.

1?

Mont

1mm

v‘

thanks, and

my

very best regards.

~=wz

m
.

Sincerely yours,

‘Z'w—AH—

V

Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>March 21, 1970
.A

‘
WW

‘w—Ww‘

Prof.

H. Lechner

Graz, Austria

-

Dear Helmut,

IBM

is

Our method of EEG analysis is based on an
1800 system, which was put together in 1966. For 1970,
too expensive and I would not suggest you try to use our

methods.

we

have programs

for period analysis,

power

spectrum, and amplitude analysis. as well as sleep programs.
Different methods are useful for different problems, and
I would be glad to advise you if you will describe the problem
for which you wish to quantify the EEG.
work.

Separately I

am

sending you some reprints of our

..
..

m

1-—.

...¢..,..,.,.,.,w.-Vw,

If I

have the opportunity to spend some time

in Europe, I will surely try to

try sailplaning with

an

expert.

visit Graz-- hopefully to

y.“

“y

My

best regards.

.

..~.-.—'r.-._..

‘~'wvv"n

mm-

Sincerely yours,

.m',--w“‘

mmM—m.

Wm'ycrw‘Tﬂw-‘ﬁ-ﬁ'l—‘mn'mw

:Rﬂ.‘r"‘:w

~

ro-mw—wn—u

.v—q:«.muw-«pwy-mewwaxwrap-1w

uwvw-w—w-

it

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>,W’
M7

5“

March 21, 1970

fr. Richard de John

146 Main

Street

Maynard, Massachusetts
Dear Mr. de John,
We

(a,
:—

.y_

a“,

mid-15‘»

V’ﬁ'ﬂ‘wmﬁnwn

4-:

yuamwm-ni

'1

wsw

w-

”-1;

"w

WW

met during the Aspen Brain Research conference, and

I was very impressed with your presentation. Since then, I have
investigated the various problems in my laboratory, and I am
writing to obtain your cooperation in the following problems.
My present work is focussed on the analysis of EEG
signals in real time by period analysis. Our programs also permit
power spectral analyses and sleep prints. Outputs are by

The data
printer and on scope. The work is not interactive.
and
then played back in
is collected in various centers on analog tape
The
treatment,
statistical
the computation center.
outputs undergo
used.
and for this card outputs or disk are
Our present configuration is Grass polygraph Model 7;
Ampex SPSOO; and IBM 1800 (2 disk drives, 16K memory) printer).
The questions: For our present applications, what is the

appropriate configuaation of the
To

ﬁ/‘u‘v‘r-K'rai'qumuwmwvs"v-xaﬁ'u‘ur'I...

facility

-—

*mvrmnwwv—

'T‘”

at

what cost

7

transform our present programs,

what may be a reasonable cost
x

PDP—lZ,

7

I would appreciate the opportunity to have you
to discuss this.
Many

visit!

our

thanks for your consideration, and your patience in Aspen.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/
*

or one of your associates/

�</text>
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                    <text>March 21, 1970

Grune

&amp;

Stratton

381 Park Avenue South

New

York 10016

Gentlemen:

on

my

Kindly enter a subscription to
behalf, effective with the January,

annualyy

Comprehensive Psychiatry
1970 issue, and renewable

until cancelled. Please address the subscription to

office at:

Max Fink, M.D.
39 Arleigh Road

Great Neck,

New

my

York 11021

Thank you.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�March 21, 1970

Headley Bros. Ltd.
Ashford, Kent, England
Gentlemen:

I should like to reinstate my subscription to the
British Journal of Psychiatry, beginning with the January, 1969
issue, if that is still available, and continuing annually until

cancelled.

Please address subscriptions to
Prof.
39

Max

Fink,

Arleigh

Great Neck,

1969

my

home,

M.D.

Road
New

York, U.S.A 11021

receipt of statement, I should like to
subscription and prepay 1970—1971.
Upon

pay

Thank you.

Sincerely yours,
Max

Fink,

M.D.

for the

�</text>
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                    <text>\March 21, 1970

Dr. Mohammad Rashid Chaudry
83 Shah Jamal Colony

Lahore, Pakistan

Dear Professor Choudry,

It

of you to write about the tbssibility
Nadees. It is my understanding that his
training director will permit him 2 months time away from the
College this summer and, if he wishes to undertake a longer
project, to do so next year for 6 months.
of a project with Dr.

,I

was kind
A.

believe that

do

2

is too short to
setting, but I am

months

accomplish any meaningful mission in a new

delighted to cooperate by suggesting a number of projects which
he could examine with your staff; and if the proposals are
satisfactory to you as well, we can try to do as much of the
peeliminary work here, so that his six months sojourn may be most

useful.

which we

Among

the possible projects are the following,
him, and he may examine in greater

will discuss with

detail with you:

A

comparison of

unilateral

and

bilateral

ECT:

are particularly interested in the new techniques of delivering
ECT within 3 sittings, usually 6 days. The technique, called
multiple monitored ECT (MMECT) is quite successful but needs a
larger population for validation.

We

An evaluation of concentrate vs. capsule
phenothiazines, with blood level monitoring in the treatment of
schizophrenia.

Treatment of acute schizonhrenic patients with

cupriming~— a

chelating agent.

available,

If opiate dependent (heroin, morphine) are
are particularly interested in the use of antagonists,

we

and these may he made

agree.

available for experimental purposes,

if

you

There are other projects as well, and these may
be discussed with Dr. Nafees. I will give him some reprints of
our work as Well as some preprints and protocols of ongoing
studies so that you can see the projects in the context of the
ongoing work.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>March 21, 1970

Prof.

H. Lechner
Graz, Austria

Dear Helmut,

IBM

is

have programs for period analysis, power
spectrum, and amplitude analysis, as well as aleep programs.
Difforeut methods are useful for different problems, and
I would be glad to advise you if you will describe the problem
for which you wish to quantify the EEG.
We

work.

Ev

am

sending you some reprints of our

beat regards.

sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

33',

gr

\

Separately I

If I have the Opportunity to spend some time
in Europe, I will surely try to visit Graz~~ hopefully to
try sailplaning with an expert.

:.

z

it

methods.

rmrvwaawu—avmw

.4

Our method of EEG analysis is based on an
1800 system, which was put together in 1965. For 1970,
too expensive and I would not suggest you try to use our

..

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                    <text>March 21, 1980
Dear Andy and Betty,

very much

for our

Congratulations on Deborah Jane's arrival ! I
name Deborah, and in fact, Martha and I used
daughter, Rachel Deborah.

like the

first

it

I look forward to seeing you in Prague, for indeed,

planning to attend, having been asked to monitor a program
in hallucinogen and amphetamine abuse. I am not sure that my
family will be with me, for I am planning to get a house somewhere
on the Meditteranean and spend many weeks away drom work. I
have a project proposal to study marijuana in Athens, which is
before NIMH and if they consider it useful, they may fund it
before the summer.
I

am

_

The family is well. Jon is away at Colby College
and
we
hear from him every few Weeks. He is a ski
in Maine,
and
seems to enjoy College between ski runs. Martha
enthusiast,
is enjoying her teaching; the girls seem to survive the many
crises of young people.
’

is progressing well, despite a very hectic
college is planning to move from Manhattan
organizational situation.
Our work

.
,._

news",

..

.7,

1:1,“

.
v.—

Our

to Westchester, and while we thought it was many years away, the
realities of our economy forced the school to decide to move as soon
as possible, preferably before 1972. So, we are involved in planning
programs in Westchester; moving part of our Department to the
new Mental Health Center which should open this winter; and keeping
up with the demand for service—- particularly since we are involved
in studying and treating Opiate dependence. In this period of
rapid growth, I am sure that we will be able to find a place for you.
(I forgot, we also have a new relationship with our local state hospital,
and one of my students has become the Director. I am to assist them

in setting

up a

center like MIP).

.«.-.A..-‘.w.-«.r..

best study has been our ECT work. We have
that unilateral ECT does indeed have less memory effects than
The

wr-H

'YI’vy‘W

Tani—,1

«pwmw

In.“

‘74-“

I'_".'r.w

found

bilateral, with

Hoppital, where we are dning the study, is planning to visit South
Africa in late April or May. Dr. William Karliner is an excellent
clinician, and you may enjoy having him visit with you and those of
your associates interested in ECT. I will give him your name,

trust

he

will call.

brother. He
return
enjoyed his trip very much and is saving busily to
trip. Indeed, he has tried to seduce my family into talking me
into going to Africa—~ and perhaps we will.
‘

”Ruin:

.
.

.

w_w

IVL'E'W

-rm-—

clinical response. This has encouraged

try multiple treatments in one sitting, and we now are examining
the possibility of treating depressive patients in 3 sessions, 4 seizures
each (so-called multiple monitored ECT). It is quite successful, and
the anticipated memory effects are just not observed, even on sophisticated
tests. Incidentally, one of the practitioners at Gracie Square

us to

and

'rPV'nr-a'“rmvsp-

almost equivalent

dinner in Prague.

Many

thanks for discussing

Keep up your work, and
Mv

SA

with

my

make a

I look forward to

hear rewards: to which Martha adds her

own.

�</text>
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                    <text>March 23, 1970

rr’.

w.

w—

Dr. John A. Sclgliano

Executive Secretary (NIﬁH)
Psychotomimetic Agents
Advisory Committee
FDA—NINE

Center for Studies of Narcotic and Drug
National Institute of Mental Health

Abuse

5454 wisconsin Avenue

Chevy Chase,

ﬁatyland 20015

Dear Dr. Scigllano:

Enclosed is a progress report of our work, a record
of the usage of marijuana, and a copy of the IRS Tax Stamp.
each.

Qur present schedule anticipates 40 experiments, 1-1.5 Grams
We would like to begin in mid—April and work
through the

summer.

If available,

may we

request

100 Grams

marijuana of

potency approximately equivalent to our present sample, VINE-l?

Sincerely yours,
Max

Pink,

”.9.

Professor of Psychiatry

MP

:kp

enc.

Tax Stamp

Progress report 3/1/70

Use

of Murijuana

�3/23/70

RECORD OF MARIJUANA USED

12/4/68
12/18/68
1/15/69
4/18/69
11/29/68
12/6/68
12/20/68
1/22/69
1/29/69

.
.

17.0
11/10/68
through 11/26/69

(1.0

1

Gm/day)

3/2/70«3/S/70 4.0
(1.0 Gm/day)

Gm

2.0

Gm

3/6—3/11/70

3/5v3/6/70
3/5/70
3/6/70
10/31/69
7/28/69

3.0

1.
1.

Gm

G

»

.0
0

�</text>
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                    <text>March 25, 1970

Dr. William Guy

Biometric Laboratory,
1145

washington .
Deer

Rom

618

Nineteenth Street, N.w.
D.C .

20036

Bill,

called your office yesterday and spoke to Ron regarding
that we needed. Enclosed is the formal request for
the forms which I asked to be shipped yesterday.
I

some forms

I also inquired about the status of the data of our ARR-1900
study and Ron was surprised when he checked our file for he stated
thet nothing was due. He clso checked the files for Dr. Simeon
and the same was true. On December 4., Dr. Simeon sent the date
of our study. I would appreciate your checking.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

�</text>
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                    <text>a“...

.—

m—w‘.‘

-

-wm“

—.

«nu-m”!

W"

W“

'March 25, 1970

-

San Francisco Hilton

Mason and

O'Farrell
California

San Francisco,

94109

Actuation: Raservation Manager
Dear

Sir:

With regard to my reservation for May 7. I will be arriving
on American Airlines Flight 15 which is scheduled to be in
San Francisco at 10:00 p.m. Please change checkain timc to 11:00 p.m.

Sincerely yours,
Max

Fink , Md}.

Professor of Psychiatry

�</text>
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                    <text>March 25, 1970
Mr.

Earl Ubell

CBS—TV

New

Dear

York, New York

Earl,

have been requested by an assistant of Dr. Stanley
Yolles, Director of the National Institute of Mental Health,
to make available any visual material concerning our research
We

presentation to the White House. I would be grateful
available copies of the naloxone and
marijuana reports, both of which I consider excellent
representations of our work.
for

a

1F you could make

I am most

grateful ion your cooperation.
Sincerely yours,
Max

Fink, %.ﬂ.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>WWW

March 26, 1970

Meditoch, Inc.
65 Rogers Street
Cambridge. Mass.

Gentlonon:

and

I have read the report of your automated patient interviewing

clinical laboratory reporting programs for hospitals in the latest

issue of Computerworld, and would bo interested in obtaining any
public information regarding the availability of the programs,
whether their input may be adapted for psychiatric use, and the
charges for programs and/or services.
Many

thanks .

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>.T. 1,,” 3,.”

var

‘,».,

ﬂu, -

m...-W. w...“ “Arum“ "haw ~.:W_4..mw‘.rywn-ww~ .-...v~.-m",

,

rm

tnw

.

”mm.

.,

‘

w...

.m

._w~w..lm.—mm

'w-nqr'mmir-r‘w

March 26, 1970

Dr. A. Dlmascio
Boston State Hospital

Boston, Massachusetts

02124

Dear A1,

his oo-workers, Drs.

Robson and Castanaga,
the meetings on child and
adolescent psychopharmacology. I was most delighted to hear
Dr. Simeon and

were very much impressed with

fine presentations, particularly that of Don Klein.
Congratulations and many thanks for permitting my staff
to attend.

of the

many

'

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>”r.‘me-WVM7

-

yam

w-

March 26, 1970

Dr. E. Leong way

Department of Pharmacology
University of California Medical Center
San

Francisco. California 94122

Dear Ed,

interested in the catechol amine theory of
Opiate dependence, and read your 1969 NRC report with interest.
In discussing the possible mechanisms with Doris Clouet, the
reed from your review for her book, and I am writing to ask if
you can make a capy of this summary as well as other relevant
reports available to me.
I have become

Your data suggests that serotonin antagonists, like
cinanserin, may reduce opiate dependence (and opiate drive?)
in post addicts, and if this is possible, it should be tested
in men. Have serotonin antagonists been given to post addicts?
With what results?
Many

thanks.
Sincerely yours,
Max

Fink,

%

D

Professor of Psychiatry

Mszp

�</text>
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                    <text>March 26, 1970

Dr. S. Clyde Strickland
Herck Sharp 5 Dohme
West

Point, Pennsylvania 19486

Dear Clyde,

have been notified by the FDA that INU 5590 dated
March 30, 1970. has been issued for our study of £~a1pha~
acetyluethadol. Enclosed is an IRS 2513 for 20 Grams.
We

Many

thanks for your cooPeratlon.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>w
-..

v

«gm-wr

A

Mm...»

March 26, 1970

Dr. E. Leong

Way

Department of Pharmacology
University of California Medical Center
San

Francisco, California 94122

Dear Ed,
'
""‘

"‘

"
“r“

"(w-39?"

ur..-.w;,;--ur-=-

yumv-yum)

m“,

y.

*‘1'

"11W“

interested in the catechol amine theory of
and read your 1969 NRC report with interest.
In discussing the possible mechanisms with Doris
Clouet, the
read from your review for her book, and I am
writing
to ask
you can make a copy of this summary as well as other relevantif
I have become

opiate dependence,

reports available to

me.

Your data suggests

that serotonin
like
cinanserin, may reduce opiate dependenceantagonists,
(and opiate drive?)
in post addicts, and if this is possible, it should be
tested
in man. Have serotonin antagonists
been given to post addicts?
With what results?
Many

thanks.
Sincerely yours,

«-

..

uyyyv.’

mgmn

Max
‘:

'
awn:

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                  <elementText elementTextId="103231">
                    <text>”v»:-‘.-w»«;.u-..-g

”mnt'n‘:

any!

(«mu-‘WWW v...

.

—w0'ﬁm”'—m wwwmmwmscmxw

-,~

‘

or.

Mow

ﬁnnnuol Parlnuttor
York limos

m

3a.

1979

new York, Ron York

Door

ﬁr. Porlauttor,

Your article reporting acoroooototlvo attlogor'a plan to
introduce a bill “. . . to Fight Youth Addiction” (av? 3/29, pg. 61)
is misleading in associating ruporto of‘horoln and unsuish under a
single addiction hoaoing. Tho rtuort doocribos a program to control
heroin adalotiou; includes, without o.brook, a roport on arroats for
hashlsh; and concludes with c tooort of two docths ascribed to heroin

ovordocago.

Tho sanéwlchlng of hsohlih botwuoo two atories of heroin undo:
a single addiction title associatos two alsparoto drugs under coo
opprohrlous title, and is not up to tho yroﬁhsaod standards of the
Row

York

limos.

l. Hashish is not horoin, is not an opiate, ls not dopendenco
producing, and has distinct pharmacology, chooistry and offbcts on
tissue: (ruforonccs may be supplioé). one could oaks as good a
caso for associating ethyl alcohol god oulatos, as cannabis and opiates.
2.

There is no proven biological tssocintiou between the two

drugs. All associations are legal and social.

3. The confusion ongondoroé by equating the two drug classos
oncourngos mlslntorprotatloua by the goblin. Lawyers weaponsible
for low: equate cannabla and opiates (sou the omnibus urug Bill

Earljuano users are rooortod to try horoln
of addiction when marijuono importation is
risks
attending
its
curtailed. Criminal gonoltloo for too abusa of‘tho two drugs or.
often confusod.

gauged by the $onoto).

with

sincerely yours.
us; Fink, ﬁ.5.

Professor of Psychiatry

2%?

:kp

bcc:

A. O.

Sulzborger

be encouraged to review the differences
in drugs with some scientists. I imagine a seiinar in clinical
pharmacology would be useful. It can be arranged.
Your

staff

may

�</text>
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                    <text>*

,

annwn—mm.w_ww

,

I'W

~WIR

March 30, 1970

Dr. Sidney Malitz
722 West 168th Street
New York, New York 10032
Dear Sid,
The request of Dr. Joseph Meiers for a volunteer task force
of psychiatrists to support opiate dependent subjects in the
community using methadone was reviewed by an ad hoc subcommittee
of the Committee on Biological Therapies of the New York Society
for Clinical Psychiatry.
We

are aware of the public need and demand for care, but we
direct action be taken by the Society at this time.

recommend no

To recommend a single treatment model in a condition as
complex as opiate dependence is not satisfactory. The apparent
need is for recommendations regarding the applicability of an
apprOpriate therapy for each case, i. e. , substitution therapy

(methadone, heroin), antagonist therapy (cyclazocine, naloxone),
withdrawal and rehabilitation, group therapy, etc. To document
such a recommendation is complex and may be undertaken by the
Society. However, the issue is of national, not local concern

alone, and an APA task force may be a more appropriate body to
provide the necessary resolution.

The subcommittee, aware of the motivation for Dr. Meier's
motion, suggests that the Society review pending Federal legislation
(particularly HR 13743 and Senate 3562) to lend support to those
aspects or bills that may serve the interests of Dr. Meier's motion.

Respectfully,
Fink, M.D.
Professor of Psychiatry

Max

MF

:kp

For Drs. A.

M.

Freedman,

M.

Nyswander and V. Dole (ad hoc

consultant).

�</text>
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                    <text>——

l

-.~mmnu——~——vm mam_w.—.v

ﬁarch 30, 1970
Dr. sidney Merlis
Central lslip State Hospital
Central Islip. ﬁe» York
Dear Sid,

for

I would like to second the nomination of
membership in the ACNP.

ﬁt. Ali {cskiner

0r. Itil and I were responsible for bringing ﬁr. Keskiner
United States upon the completion of his treining program
the
to
Montreal.
in
Since 1964 he has been an active member of the stuff of the
Missouri Institute of Psychiatry. For the first few your: he was
in charge of the patients of the chronic schizoyhrenia project,

studying the effects of butnperetine, L59, Bitten end atropine
in altering the behuvior of the therncy resistant petients.

He has done same of the most extensive evaluations of fluphenazine
decanocte. Based on this experience, he has undertaken and is new the
principnl investigator of I study maintaining chronic psychotic patients
in a farming community. He is able te do so by delivering medication

in biweekly dates.

ACE?

I am pleased to recommend Dr. Keskiner for membership in the
as I believe he will make significant contributions to our

study groups.

Sincerely yours.
Ht: Pink, %.0.
Professor of ?sychiatry
$3? :11}:

cc: Dr.

Itil

�</text>
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                    <text>February

l.

l970

Professor Paul Kielholz
Editor. Phareekopsychiatrie
Basel, Switzerland
Dear Dr. Kielholz.
I have

just received your letter regarding

a

report

on “Methadone Maintenance Treatment" for the special issue on
Drug Dependence of Phereekopsychiatrie. This was addredsed to
Bellevue Hospital and was not received until yesterday.

pleased to contribute to such a volume,
be broadened to the general topic
of pharmacologicll treatment of opiate dependence. To review the
use of methadone alone is too restricted. since we have more ex~
perience with cyclazocine and naloxone. A description of these
three approaches. as we now use them. and as we propose to use
them in our future prograns. may be more useful than one devoted
to methadone alone.
provided

I would be

that the subject could

If,

however. someone else is already covering the

antagonists. then perhaps

he would be
methadone treatment as well.

willing to report

on the

It is not possible to meet the deadline of January 31,
l970; since that is the day I received the letter of invitation.
The report could be written during the first two weeks of March and
sent about March 2i, at the earliest.
which I

I thank you

also for the answer to the

will respond to in the next

few days.

CINP

program.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>February 2, 1970
Mr. Robert Uball

Plenum Publishing Co.
York City

New

Dear Mr. Ubell,

are trying to obtain the funds to launch the
at a date earlier than we had planned
(with NINE support). We should know by the and of February and
we succeed the meeting will be held June or July.
We

conference

on marijuana

If not,

we

hepe to hold

as soon as the funds allow.
Thank you

it

in the late

fall

if

on

for your interest.
Sincerely yours,
Max

sink,

M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>"-

‘“

"9‘

"

x

-"-v-

'

"i” '6'“)

»\'-.r.«-

«ﬂu-«m»

saw—aw

mummww—w‘wo "ﬂ“.

-7“—

my—

Fabrunry

3.

1970

Dr. Gerry Klernnn
50 Alston Avenue
New Raven, connecticut
Dear Gerry,
Tua wegks ago I had the aecoad meeting with editors of
Plenum ?ub113h1ng~~ first with Mr. Uball and than ﬁr. Weingarten *«
who discussed the feasibility and need for an ndéitional journal
I believe
devoted to drugs and behavior or drugs and brain function.
dedicated
in
if
such
it
15
a
need
particularly
for
journal,
that there

to studies in man. Mr. waingnrten reviewed a list of our cauworkara
friends with whom he had apnken, and I sharad with him some of
of the work they had éone.
views
my
and

was favorably inclined to the
It was apparent that hehad
which
expressed, and I encourageﬂ
venture
you
of
thia
support
him to continua to alicit your support. Tha meetings next week at
the new York Hilton may provide the opportunity for a review of this
suggestion, and I hopa that yen will provide the guidance which

he

may

Inquire.
My

be drrnngad.

has: regards.

and I do hogs

that something can
Sincerely yours,
Max

.,,,

_..r,.,.

m

nvr

“7",...“

army.--

~
.

'mbuW-DVWW-

Pink, 3.9.

�</text>
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            <elementTextContainer>
              <elementText elementTextId="42232">
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              <elementText elementTextId="42233">
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                  <elementText elementTextId="103226">
                    <text>February 3, 1970
Hr. Scyneu Weingartan

Dear Mr. Weingnrten,
Bur laboratory

is equigpcd with

an MIST and we have a

has bean my adminintrative assistant for
well trained operator
nlaost 5 years. This unit is part of tha extensive aquipmnnt,
both alectronic and computer, of the laboratory.
who

I

do

not

know

of any other laboratory similarly

equipped in psychopharnncology, although I dié reconmand to
my good friend. Charlas Shagaaa that he opould obtain such a

unit.

Sinceraly yaurs,

Fink, H.D.
Professor of Psychiatry

Max

nf/

�</text>
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              <elementText elementTextId="42222">
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                  <elementText elementTextId="103225">
                    <text>February 3. 1970
Dr. Gerry Klarnan
50 Alston Avanue
New Haven, Ibnnocticnt
Dan: Gerry,
Tue waeks agc I had the uncond matting with editars of
Planum Publishing~~ first with My. Uball and than ﬁr. Weingnrten *w
who discusuad the foasibility and negd for an ad&amp;itiona1 journal
davoted to drugs and behavior or drugs and btain function.
I hulieva

that there is naed far such a journal, particularly if it is dedicatad
to studies in man. Mr. Whingnrten revicwad a list of our co~workera
and friands with wham he had spoken, and I ahareé with him some of
my views cf the mark they had dune.

It ans apparant that he was favcrubly inclinad to the
support of thin vanture which yen had axvralnad. and I encournged
him to continue to elicit your support. Thu mattings next wank at
the ﬂaw York Eilton may provide the oppnrtunity for a revicw of this
suggestion, and I hope that yau will provide the guidance which

ha

may

require.
My

be arrangeé.

been ragarda. and I do hope that something can

Sincerely your».
33: Fink, M.ﬂ.

�</text>
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                    <text>February 3, 1970
Dr. A. M. Schneider
Departuznt of Psychology

University Callas:
Raw York University
Bronx, Kev York

Dear Dr. schnaider,

discussions in Aspen, and have
tried to ahara my notes with my asacciates. gay I aﬁk that you
send an capiao 0f ynur more recent reports an memory changes

I vary

and

cansolidatiun

much enjoyed your
?

Enciosed is the program of tha APPA which is maeting
1n Raw York February 13 and lé. $ome of the reporters era well
known and yen may enjey the presentations. I am encouragad ta invite
you to the cocktail party, and look ferward to welcoming ymu.

Sincerely yours,
Max

Fink, M.D.

Profaaaor of Psychiatry

mf/

�</text>
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                    <text>Fébtuary 3, 1970
Dr. 3. K. Vanov, M.D.

The Upjohn Co.

Kalamnzeo, Michigan
Dear Dr. Vanov,
Thank you

for your inquiry

in the «valuation programs of

anti-anxiety

compounds.

new

and

invitation to participate

paychotrapic drugs. patticylarly

Dr. Signet may have describad, our principal interest
is in the identificatian and classification of novel psychoaetivn
agents by neuraphyaiologic, particnlarly EEG, measures. Our clinical
atudies are derivativn, and we have undertaken clinical studies
As

to support our EEG determinations. Wt have iénntified the paychoactive
properties of eyelasocine, doxepin and fanfluranine by EEG prefila
analyses, and now are engaged in the analyses 0f four ‘nuaberad’
campounds. For ant of thgsa, 641299, we hava begun the clinieal

trials.

undartake chase mtudias we require saw» evidenca of
the aafaty of the compound in man, preferably normal adult volunteara,
and a aynopsia of the desage/aninnl data. May I nuggcst that if such
an analysis in of intarest, that you arrangt to visit our laboratories
at your canvcniance, and revicw the type of progrnml which are now in
progress 7 It may be particularly helpful if you sent at a capy of the
information which we raqueat. no that we could discuss a specific
protocol during your v151t—~ but, this 13 nut necessary, and may be
defeated.
To

Thank you again

for your intnralt.
Sincerely yours,

mm.

133'!"

'a,i«

Max
-t
4,.

”my...

Wr-Q-w

.
x

«r

w—w

r’ﬁ“

Fink,

M.D.

Prefesaot of Psychiatry

”MW

nf/

�</text>
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                  <elementText elementTextId="105817">
                    <text>-.-uﬂ

TO:

Alfred

FROM:

Max

M.

Freedman, M.0.

February 4, l970

DATE:

Fink, M.8.

SUBJECT:

Attendance at Executive Faculty Meeting

The

principal issue at the Executive Faculty

change in curriculum

third
Dr.

was the

increasing weeks for medicine in the

—

and fourth year and decreasing psychiatry and surgery.

Jaffe indicated that psychiatry

in a gentlemanly fashion.

great concern that this

The

had accepted the decrease

surgical representatives voiced

recommendation would be

disastrous

to the surgery training program.

It

that

was my impression

Dr.

Jaffe's report

was poorly

described with inadequate support of the numbers in the proposal.
He

was unprepared and

had many

errors in

On

a vote

On

a vote

insisted that the report submitted (appended)

it.

to table,

W

I

abstained.

to accept the report,

I voted

The/yote was not accepted l3 to 12.

MF:kp

against acceptance.

�</text>
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                    <text>‘

"WW-"WW

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“a WWW-w“,«mp-unm
rv-m

,

V

,

,

.

“we-WW we.
,

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,

meumw

,, W "ma-mm
_,

um .‘lm-‘WHW."M_.‘..,

w , w.

W._.w..~~,uu—w-xmWWII—V

February 4, 1970
Dr. Simon H. Nag1er

Department of Psychiatry
Metropo1itan Hospitai Center
1901

New

First

York,

Avenue
York 10029

New

Dear Sy,
he have no "innovative” ideas on how to supervise residents
mode]
in psychiatry. We have proposed that the continuous care on

emphasis
of the Division of Bio1ogica1 Psychiatry, with our
tempora1,
artificia1
a tota1 treatment approach, without
a usefu1 experience
phi1osophica1 or moda1ity restraints, may beone-ha1f
the patients
than
more
we
that
aware
are
for students.
- and higher
reuadmissions
services
are
admitted to our inpatient

emphasize, therefore, some experimenta1
of interest.
approaches to therapy, and this, in itse1f, may be uni1atera1
ECT
as
innovative,
are
Sure1y, some of our techniques
and mu1tip1e monitored ECT for depression; na1oxone, cyc1azocine
f1uphenazine enanthate
as “engagers” for opiate dependence; injectab1e
and doxepin
and decanoate, and e1ixer butaperazine for schizophrenia;
and high dose ch1ordiazepoxide for anxiety. Hot to forget ourand
specia1 interests in 1actate precipitab1e anxiety, cannabis,

for drug abuse subjects.

We

EEG.

V

,,

“WWW“,

,;
'M'm

w.»

.r-

-

a staff
Sureiy, among this wea1th of nove1 experience, withFe1dstein
(Professors);
Shapiro
Kee1er,
consisting of Drs. Fink,
Simeon, Vo1avka
(Associate Professor); Dornbush, Resnick, Rubin, and
Zaks (Instructors) Major
(Assistant Professors) and Abrams, C1are,
and
we shou1d be abie to engage a group of enthusiastic,bright
dedicated residents in a reciproca11y rewarding experience!

,.

Sincere1y yours,

“n“,

n
n

Fink, H.h.
Professor of Psychiatry

Max

‘1',“

’

.

.11"

MF:kp

wwl‘wm‘ww-we-gm,

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                    <text>wow-w—

.~
&lt;

m

.,

r
w,

u

wwmw.u.r.wn

mwr

”Ir.-

February 5, l978
Dr. ﬂax Singer
Quaker Bridge Road
Croton on the Hudson. ﬁew York l0520
Bear 3r. Singer:

visit

a few weeks ago was a disturbing experience.
The State authoritias wara once again seeking a review of drug abuse,
and the chaice of a team without prior exparience in similar medical
Your

problems. highlighted the bankruptcy of tha existing

ﬁat,

if we

state efforts.

are prﬁsumad to be experienced, what pro rams
burst of activity, I éictated the ant osed

do we suggest? In a

untes.

In reviewing these notes. I am aware of how little we know
of érug abuse - how it starts; the physiological changas; the
pharmacology of the drugs and their antagonists. ggg;_
It is

clear, however, that there art axtensive differences betwean
apiates and cannabis « the opiate dangers are clearly definad;
the cannabis dangers overdrawn and unsuhstantiated. while
intensive research an ogiates is mandatory, a maratorium
a moratorium on imprisonment.
an cannabis can be safely antertained
new laws, legalization combined with an extensive study effert
to answer the cogent questions 9f the suprlies 0f cannabis and
m

their dangers.

cf

against opiates is not too
our nation seems embarked on a 5 billion dollar annual
expenditure against a Chinase threat * is it too much to ask
absurd
$530

Perhaps the analogy

5 “war”

~

millien for

a “Chinese“ epidemic?

May I submit a special plea. for inclusion in your report
regarding opiates? ialoxone in a silastic vehicla is a simple,
direct and feasible aid in treating this disease. The funds needed

�.

Fwy

rm-

-

~r-v-vn

wwwm'mmmm

man‘s-zap

.m-

.-,. .vﬂ—pw,

-. .V. W——M...

.

,

.uW‘wwn.—w

M, s.

"-Yw-ri wawmwx -—u—-~-mv7ww———cw——-.--:

.7“? Team-WV." -V-

-2-

Br. Singer

.......- u.

».

__,_,

“.7 ‘m,——.1_’—.-w.

wvr,....._..

.

WV

vamp—"q...”

February 5, l970

for development may be small in amount ~ we have asked $70,000 the
first year and yet, the promise is so great, that this nominal
expenditure should he "slipped in” among any recommendations. If
successful, the rewards will be most gratifying. If unsuccessful,
—

the loss
I

trivial.

while

would be

of your

understand your report may have a restricted distribution,
qrateful for the opportunity to review a copy with a member
I

staff.

Sincerely yours,
ﬁax Fink, %.U.

vrofessor of ?sychietry

ﬁF:kp

cc:

Mr. Gus Tyler
27 Stoner Ave.

Great ﬂeck,

New

York

.

.

�</text>
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                  <elementText elementTextId="103223">
                    <text>~—

V

".7"...

, ....m- ,m

A

-

‘vrym-‘uw

--'"'n"mv-m|n ~,J—a.v1.:m, D’s-Inv'm—p'r.

-

r,

n..- N‘v‘muw-m

mgv..-~w-vmn—.W‘www

.n-uw—w;

~7y.a'-&gt;wav~wwu-~PI“V—Frrf—I'wvw

Fibruary 6. 1970
Dr. Robert Iokcski

Director,

Drug Abuse Laboratory
Grova
State Keepital
spring
Baltimore, Maryland
Dear Dr. Kokoaki,

for the raport of the analysis at car
substance. whiah apparently containeé
Bangle of
heroin. This is inﬁaad hnlpful, and wa are grataful for your
assistance.
Thank you

unknown

a: the

I trust I will hava

was meetings.

an apportunity to see you

sinceraly ycnrs,
Fink, H.D.
Preteens: of Psychiatry

Nan

mf/

1..

~

,

“WV

‘

v

r". “w. (”W— _,

�</text>
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r,“
I.

Febmary 6, 1970
Mr. Barry Henderson
World Wide Medical News
110 East 59th Street
New York, New York

Dear Mr. Henderson:

for your inquiry about our presentation at the
This report was an up-dating of a review I completed
in 1968 and our recent studies in opiates. Copies of both

EPRA.

Thank you

are enclosed.

Sincoroly yours,

Prodbssor of Psychiatry
MF:kp

�</text>
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                    <text>February 6. 1970

,w

Mr. Robert Marlin

mwvrP-KI-"p—‘Il—IIWVF‘

Sande: Pharmaceuticals
Hanover, New Jersey

mm—m

..

Dear Mr. Marlin,

w-v.-u..y

&lt;

”-..—W)“-

"-

usu-wm-u

rmvl'"

,

7

Thank you for the information on thioridazine in
the treatment of anxiety in out-patients. The data is helpfui.
suggesting both a very broad range of dosages that may be
effective (30»300 mg/day) and a high degree of safety. There
is no satisfactory comparison against a standard antiﬁanxiety
agent, however, and I wonder why this has not been examined.
I checked my reference texts as well, and found some references for
a few of the antipsychotic agents. but none for Meiiarii.

.-u-

m

-qrv~

As I mentioned, we are inciined to undertake
of Meiioril in out~patient anxious neurotics.

The

a

study

study of 542.548 is progressing well.
Sincereiy yours,

-

7mm-

n.»

.....u—unyq-wwa-w

Fink. M.D.
Profossor of Psychiatry

Max
urn-w")

Jaw

A,»

.‘A‘v-W‘uy,“

,;,~w~g_

«m.

A

“’lwr'wa'yn’"!

wWVVm‘A't."

.
w

mf/

�</text>
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                    <text>February 6, 1970
Dr. Bidney

Halitz,

APA¢Diatriet Branch
250 west 57

New

M.D.

Street

York City

Dear 51d.

I thank you for your axptasaion a! confidence in
the appointment as Chairman of the Cammittaa of Biological
Tﬁnrapisa of the district branch. and would like to accept,
but an unclear as to the reponaibilitien of the asaignuent.
Is the committee appointed already. and who are the Numbers ?
0:, may I recanmend a committee from the membarchip for your
approval ?
Are there questions before the committee? Are share
ongoing projects that may be raviewad and centinuad, at is the

coumtttee beginning

anew ?

I will call you to éiscuss these questions before
replying ta your kind recommendation.
My

best regards.
Sincerely yours,

Blnfatnhr ufnroychiacry

�</text>
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                    <text>February 6, 1970
Dr. Robert Kokaski
Director, Drug Abuse Laboratory
Spring Grove State Hospital

Baltimore, ﬂaryland
Dear Dr. Kokoaki,

Thank you for the report of the analysis of our
unknown
of
substance, which apparently contained
sample
heroin. This is indeed helpful, and we are grateful for your

assistance.
at the

NRC

I trust I will have

meetings.

an opportunity to see you

sincerely yours,
Fink, 3.9.
Profeanot of Psychiatry

Max

mf/

�</text>
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                    <text>—

.1...

February 7, 1970
Mrs. Lala 8. Le;
Chairman, Ccmmittee on Mndicine &amp; Law
Association of the Bar of the City of
42 what 6k Street
ﬂaw York City

.Mpv..§.x.as~.r:-w.wsuw-

It

of your committee to invitc us to participate
in the symposium on marijuana, and we enjoyed the sasaion very much.
I rcgrat that our participation was limited to audition. since
there many inputs raisad and can» facts presented that were in
error. The issue of marijuana is in the public eyn. and the
extan-ive penalties for possession are indead absurd and dis~
proportionate, and this was clearly atated by Dr. Mead and Er.
Rothwax. Unfortunataly, both ﬁt. Rainlip and Dr. Zinbatg mgde
misstatamtnts of fact~~ Mr. 3513119 in regard to the studies
of THC and the allegad toxicity of cannabis: aad Br. Zinbarg in
not distinctly aapnrating the toxicity of opiataa from cannabis.
wan kind

Whila the problem of marijuana in acutc, the prablems
dopandencc and their treatment are not only as acute,

of opiate
but the severity of the illness is so much greatmr, uni the
'epidemic’ so much more severe, as to be a public health problem
of major magnitude. The legal issues of entorcad engagement with
methadone~« an oxperimontal drug~¢ or the justification for
incarcaration without traatmaut may have been discussed, but
sacm to us still :9 ba open innues. Ferhapa your committee may be
interested in discussing these problems at another occaaion.
Again,

1114mm":

x

York

Beat Mrn. Laa,

”hamburg,

”WWW‘MA”,

N$W

your excallent

my

wife and I thank you for the invitation and

haspitality.

Sincerely yours,
Fink, 24.9.
Prateasor of Psychiatry

MRI

uf/

�</text>
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                    <text>:‘zw. -

V»

w

;

-_r ....

Mm m

1“,.

.. w. m,

.

mwﬁm- "WT“,—K..."

m

v

v

v

n

mum...“

.7...

-7..-v-.w-_m.,v_ .. .,,v..r_.,..r

/

.n

,

h,

_-..‘.~_._,.a

.

.l.m.,

.,,,

.7

..

February 10, 1970
Dr. Martin Katz

\-.

'r
-

.w.,--,u.w.w—u—c~:,

&lt;1:

National Institutes of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Dr. Katz:

Enclosed

for
to DRG.

is

MH—lSSél-OZ.

“a

xrvuu

14

"thy

«mum.

‘

'(axwm:

a copy of the sppplement grant application
The original and six c0pies have been sent

Following the guidelines, the dates of the supplement
to run concurrent with the ongoing program so that
are
the first request is for six months rather than 12 months.
made

I want to thank you for the extension of the February
deadline and I would be grateful if this supplement can be

processed for the June Council.
wiwvv

Thank you

for your help.

mu—n»

Sincerely yours,
Max

Fink,

H.D.

Executive Director

MP

:kp

1

v

on

�</text>
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              <elementText elementTextId="42092">
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                    <text>.‘

Y'ﬁes-«v'w

Irraw-

February 12, 1970
Dr. Edward Woodward,
A. H. Robins Company
1407 Cummings Drive
Ridhmond,

Virginia

Jr.

23220

Dear Dr. Woodward:

fcnfluramine-behavior study (#0761) was undertaken
following our observation that the EEC profile was more like
amobarbital than dextro-amphetanine. Since we had no prior
experience with studies of weight reduction and anorexia, we
proposed a study to observe the behavioral effects of fenfluramino
and placebo. Since this was not feasible without a protocol, one
The

was

filed.

double-blind, with neither the subjects nor
the observer aware of the medication given.
Tﬁe study was

In tho

during the

subjects, sedation and somnolence occurred
first few
2—4
days of drug trial, and did not with placebo,
initial
which

by the

1.8.,

reports of the subject

we

were able

medication they received. We confirmed this
breaking the first 7 codes.

after

to discern
7 subjects

by

An

analyses of the behavioral data indicated that sedation

At

this point,

was indeed the most prominent symptom.
we

cases. found only one
Since

we

were

continued the study and with succeeding

reporting stimulation.

ill-equipped to

questions of weight reduction,
difficult group of subjects.

we

answer the many

relevant

had prohloms in managing

this

In a telephone discussion, I indicated that I was satisfied
with the behavioral data, remarked on the difficulty with the
weight reduction aspects, and recommended the study be discontinued.

�//-

Dr. Woodward

With

February 12, 1970

~2—

this badkground, the following are Specific answers

to the questions:
1.

Study was double-blind.

Crossover resulted from a desire to assess the
differences, if any, in behavior. Also, since the subjects
signed a permit that included "placebo“, at the end of the study
they inquired whether they had received "drug” or “placebo”. For
the pationts who received placebo, a trial of active drug was
2.

offered.

3.
4.
I

\soo notes this letter.
Supplioﬁg see attached.
FDA:

trust this is reogonsivo and usefbl.
it Siggoroly yours,
'5.“

Fink, H.D.
Professor of Psychiatry

Max

‘

Mszp

/‘\\

//A7[\Jx7

�</text>
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                    <text>-«

0'1""

wry-(m)!

m

February 16, 1970
Food and Brug

Administration

Washington, D.C. 20204

n
.Wﬁ...

um",

"gm-ow

Attention:

Merle

M.

Gibson, M.D.

Dear Dr. Gibson:

5mm

wimp-v.

Enclosed is a protocol and supporting data for a study
of ”i-alphavacetylmothadol as a Maintenance Treatment of
Opiate Dependence." This study will be done in the Uepartmont
of Psychiatry at the Metropolitan ﬁOSpital Medical Center. he
program is part of our ongoing treatment and evaluation studies
under the auspices of the New York State Narcotic Addiction
Control Commission.
have been advised by the manufacturer, Merck Sharp and
Dohme, that supplies of i-alpha—acotylmethadol (MK-790) will be
We

.availablo as soon as we obtain an IﬁD, and the enclosed material
has been prepared by them for submission.
Thank you

for your attention.
Sincerely yours,
ﬂax Fink, M.D.

Frofessor of Psychiatry

MF:kp
6116.

�</text>
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a

‘u‘:"\-\ WV... _..—...~—.

~nm.t'~n‘wmw'nwu"&gt;‘t!wwﬁ‘wm

7‘-

__...‘v_..__..___—.~. m.

._ “v, -.. —...w_.‘._. WWW.-.—
.

....mvu._..r w.

‘.

A

"awn-1

..¢&lt;w..w

w..7_,-

—

n

,

“w.—...wp-y..

m;

-.vaW.—wr

February 16, 1970
Dr. Allen P. Burger
Chas. Pfizer &amp; Co.

Groton , Connecticut

w

,‘1

1

man

Dear Allen,

wart-rm

n'

-

Separately I am sending you the part of the sample of
thiothlxene which we are using in our EEG study. ﬁy staff
reports what appears to be a diminution in clinical affects.
If it is possible to biochemically check it against the
standard, I would be grateful to know that it is as active
as expected.
Hy

best regards.
Sincerely yours,
Fink. ﬁ.3.
Professor of Psychiatry

Max

HF : kp

,7—

�</text>
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wnwlnw",

m.

y

.V

&lt;

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. .

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., ,3.

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m’wwr‘wmmwmz—a

u.

n lama—u ‘rrqr-“V—V—uw—I‘r'm—‘z'n-W'V-v-‘m.VT&lt;\

am...»

February 16. 1970
Dr. John A. Scigliano, Ph.D.

Consultant, Pharmaceutical Sciences
Center for Studies of Hnrcotic and ﬁrug
National Institute of Mental Health

Abuse

5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

”—7..."

Dear Dr. Scigliano:

studies of marijuana are continuing and 1 am writing
to request an additional supply. Our initial supply was from the
Our

sample NIMH-l.

Is

it

possible to request

an

additional

500 Grams?

Sincerely yours,

Professor of Psychiatry
Mszp

�</text>
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                    <text>Eebroary 27, 1970
Mr. autumn Weioaman
Hoffman La Rocha, Inc.

Eutloy,

New

Jersey

Dost Mr. wolounuo,
Enclosed is the draft of tho proposed firot~phaoo
study of the EEC profilo analyoia of singlo done chlordinzopoxido
in adult volunteer male subjects, dotod 2-20h70. This study is
based on our dioouollons earlier this month, in which you and
Dr. Duff proposed a more dotailoé scooy of ohlordiaxopoxido
and phonobarbitol,1f a clear EEG profilo could be datinod to
a single oral done of chlordlozayoxldo.

It seems fruitlooo to uodartoko trials at 10 mg, since
good evidence that this amount may be suhathroohold, and
we have proposed trials with 25 ﬁg and multiples thoraof.
theta is

study will be undertaken in m1d~ﬂorch, and I would
appreciate your making a snoll supply of chlordiazopoxldo, a:
25 mg and its placebo available (23 oopsulea each).
The

Many

thanks.
Sineoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                  <elementText elementTextId="105814">
                    <text>February 28, 1970
Dr. William Drew

University cf Kentucky

Lexington, Kentucky
Dear Dr. Drew,
The

antidepressant paper is published in:

Pink, M., Simeon, J., Itil, T., and Freedman, A.N.: Clinical
Antidepressant Activity of Cyclanocinc~ A Narcotic Antagoniat.
Clin. Pharmacol. Therap.,_lg;élmé8, 1970.
Kaella and Karczmar citation is correct, ané the

articlc is chapter
The

52«71.

A, pp

preprint

activity of cyclazocine

on the

by

part of the article cited

EEG

identification of clinical antidepressant
criteria was not accepted anﬁ is

above (Clin. Pharmacol. Therap.)

Reprinta of chase articles arc not yet available,
but I will send them whcn they do come in.

It is good to have thc work on cyclazocine continued. It
an effective compound an&amp; I hopc that something therapeutic
can be made of it. Incidentally, we hcve bacn able t6 induct soma
patients on cyclazocine on a schedule of 1 mg, 2 mg, 3 mg and
4 mg in four days. For any side effects we have givaa either
parenteral or oral naloxone (2 mg IV or 50 mg oral) and the patients
can be discharged m uch sooner from the heapical than with methadone.
is

Sinceraly yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>/5&lt;}

A
\ng

February 28, 1970
Miss Janet Grono
Delphoo, Ohio
Dear Miss Grone,
Your letter to Dr. Taylor was sent to me for roply,
since Dr. Taylor is now in the military service an&amp; is unable
to continue his brilliant work. The war in Viet-Nam, which is
so destructive of lives, is also destructive of other good things
in our societyv~ including research.
The boat has already been published, and there have
boon no other studios. I hope that as soon as the military
releases Dr. Taylor, he will return to carry on this important

work.

Good luck

in your studies.
Sincerely yours,
Hot Pink, M.D.

Professor of Psychiatry

P.S. For a good discussion of schizophrenia, may I suggest you
request any textbook of psychiatry, particulariy the
Comprehensive Textbook of Psychiatry, edited by Freedman
and Kaplan, published by Williams &amp; Wilkins, 1968.

�</text>
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                    <text>{/fﬂr

\ﬁgﬁko‘;

X“,

Vabruary 28, 1970
Dr. William Ogle, M.D.

Street
Seattle, washington
1107 NE 45

Dear 3111,

It was kind to invite my participation in the
North Pacific nsyohiatric meetings in Vancouvor~~ and I would
have been honored to participate. I have been away at meetings
for more than three weeks, aad this is my firnt opportunity to
answer directly. My secretary tells me that the program is
completed, and I regret this. but thank you for the honor
of the invitation.
At the ACNP I mot Jerry and we discussed our mutual
friends. He is well, seems to heap an active interest in teaching
and research, and has maintained the leadership of the Psychiatric
Reaearch Society with Hy Bomber (who also was at the mooring
and is busy flying his own plane about tho country).

Again,

delighted to

My

my

visit

thanks for your thoughts~- and I would be

in the future.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Foychiatry

Max

�</text>
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                    <text>"I'M

l

.

:‘rl‘auwlv"w'lwmrp‘.u~.x

www-

,

January 1, 1970
Br. ?.

J. Fell,

N.V. Qrganon

H.B.

035, Holland

Doar Dr.

Fell,

It woo kind of you to write about our interest in
computer analysis of tho EEG. Your miasion. as described in your
is a commendable one, and I will do my host to assist you.
mothods of

letter,

Thare is indeed much conflict about the value ofoortain
ascoasmont. The history of the problem is very clear.

EEG

Since almost all practitionorl of EEG analysts dopond exclusively on
visual analysis (done rapidly and profitably for clinical purposes),
there are very few who have taken the timo to do quantitative assessmonta.
Among the few who have used various quantitative methods, there in little
disagreement; for ouch of on will anawcr the qunstion about relativo

merits of each technique by asking, ”Merits for what purpose ?" Each of
the quantitativo techniques have been useful in some project. This is
true for analog power spectral density analysis or analog amplitude
integration or analog period analysis: and similarly. digital computer
methods for power, period and anplltudc; as well as digital mothoda
for sleep prints, shape analysis, averaging, etc.
In

questiona.

this framework, I will attempt to answer each of your

l.

The most sensitive oathod ? For what determination ? In
are able to distinguish small doses of psychoactive drugs
in volunteor human nubjocta using period unalyaio (320 samples/soc, 10 or
20 second epochs) or power soectrum (100 samples/second, 50 lags). We
have separated 50 and 100 mg anobarbital; 50 mg fenflurnmiue from 50
amobarbital and 10 dextro-amphotamino; ate.

our hands,

wo

digital computer programs era written for the IBM
K), disks (2) and a fast printer. Those are
available to qualified investigators approvoé by the ﬂlﬂﬁ agonoios
who oupportad our work; or at nominal coat to industry. However, I
would suggest that it is not the packngos that you need (although those
are helpful) as tho opportunity to work through town of the programs
with members of our staff, particularly if your machine is diffetont.
1800

with

16K

2. Our

(or

8

�_

”m“

a,

._V

r,
.t

dwl

.

uwxnmrmmn

“i;
d

l

\

PCJO

Fall-OOOOIIOOIIOOOOJanuary1, 1970 It...OOUOIOOOCOOOOOOIOOUI0.0.0.02

The programs can run on

the

IBM

360/40 with 1827 converter.

3. The various technicalities I mention in my article
small
technical tricks that we have learned, painfully
are the many
and expensively, over 13 years of effort, to tease out drug effects
from EEG records. The changes are there and when working with human
subjects we are aware that it is necessary to control the environment
for noise, alerting taska,, blood sugar, etc. These controls sound
formidable on paper and are very simple in practice.
A. The

“W‘

same

programs for sleep

conditions as the other programs.

prints are available

on the

recently been invited to consult with two other
pharmaceutical firms, one in the U.S. and one in Europe, who have
expressed similar interests to your own. We have found it helpful to
visit us.
suggest that a technical representative of your laboratory
and
attempt to
we will make our facility available for your inspection
make
decisions
the
allow
to
you
work through the questions that may
you seek. In the event that it is useful, one of my co~workero or I
could visit your laboratories, to describe the available processes,
We

have

particularly in the context of your interests
I trust those

your inquiry, and

my

comments

and needs.

are responsive.

Many

best wishes for a successful 1970

thanks for

!

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>.w

«7.,wv..‘.m.¢

_,

.

V

._,..._

.

.‘._

—..,.,.,,

,.

.‘

fwwy

-._n_....i‘.

____

,

w. “in...

,..

,

.__.

M-

n

“77.7.“.7 V,“

7.

“no

.
‘rw-rw'

u.—

«.

"vn‘amr

January 1, 1970
Dr.

J.

Mondale, M.B., M.D.

Depression Research Unit

V.A.

hospital

University and Woodland Aves.
Philadelphia, Pa. 1910é
Deer Joe,

It was kind of you to invite my participation in your
volume, "Textbook of Biological Psychiatry", and I am pleased to accept.
An I read the list of prospective titles. I so surprised that you
see the EEG as a companion piece to the many biochemical essays planned
for the volume, and I hope that I will be able to accomplish the mission
in a satisfactory fashion.

I presume you wish an outline and you will not a reedonahle
deadline for the final manuscript.
You should know that I am working on e cimilar section for
the Textbook of Psychiatry, 2d edition by Freedman and Keplen. I have
diocuased your outline with Dr. Freedman, and we both agree that it is
possible to make the presentations sufficiently distinct as not to cause
either you or him any embarrassment.
My

m

best wishes for

a successful 1970.

-,
Lyra-

r"

Sincerely yours,

m-mvnumu'v

“If“?

Fink, M.D.
Professor of Psychiatry
Mex

:rpxmw'w.‘

No-

4:
I,"

mf/

9.9.

Would you be so kind as to post the enclosed announcemoot of the
1970 APPA meeting on some suitable bulletin board at your hospital ?
Bony thanks.

�</text>
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- two

...x..m~-...w—n;(—7....

~......—‘w,“..-W.—ww-vw,..,

.w

‘e'-‘

v"...

1,... ~....r~wu4-.r

...

.-

.

:

‘.

mmr-u

7W v.—.,_—vi,..,._.,~, ‘

V

,,..,_

1““!m'n-mevI-Iv‘r-"w-

A-

‘
v

&lt;

January 1, 1970

~w1;w.W1an-vwv

:I‘V'J-v

1.
«a

"wwwsmww.

Dr. F. A. Froyhan. M.D.
153 West 11

New
-

Dear

Street

York City

Fritz,

It

was kind of you to invite me to portioipato in the
District Branch program in March, and I vary ouch regret that
I will be in Denver during the neck of the noeting. I have discussed
the problem with A1 and he concurs in the recommendation of our
associate, Dr. Arthur Zakn to complement his presentation.

APA

Dr. Arthur Zak: is an Instructor in Psychiatry in the
Department. Since 1966, when he was a resident. he has been intimately
cosociatod with our studies of oyclazocinc, heroin, noloxonc and mathadono. He is fully acquainted with our data, add has attended the
rcccnt meetings of the HAS-NRC committee, no that he is fully
acquainted with the work of other investigators. (Incidentally, he
is also a yrincipcl in our studies of cannabis).

I underntcnd the proaontation in on March 12 at the
Academy of Hodicine. I will anoint him in the preparation of his
roport, and am confident that he will do a commendable job, in
doocrihing tho ptoocnt approaches to the treatmcnt of Opiate de~
pendonce and a vino of tho future. with particular emphasis on the
development of a long acting naioxonc.

‘A'W‘I'

.'
.m

.vww

.-

rwm-w,s.-;m:ywm

van-YT

mmxvm

.
1571909.

'7.)

an
.7:

“FHP'

veer.

”.31;

4'1

Im-

Incidentally, for the January prosontation (Halon), A1
recommends Dr. Myron Denholtz as a discussant. Dr. Denholtz has
been a student of Wolpo's and 13 an activn participant in our programs.
Sincerely yours,
ﬂax Pink, M.D.

�</text>
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                    <text>”I".

in

1

wnmmWw-v'm'mns

'3'"

W‘

--v

.1.

Mr.

ya!!!»

-r--

January 2, 1970
Dr. Oldrich Vinar
Psychiatric Rssearch Inatitute
Prague. Czachoolavakia
Dear 01d:1ch,,

Enelosaé la an abntraet far your consider-ting for the
fraa communicatians at the forthcoming SIN? mneting in Fraguc. I
think it would be upplicabla fer the communications in relation to
the symposium on ch: evaluation of ant1~anxiaty drugn.

I have not recaived a reply

as yet and so have an more to
My

report

ﬁram

Proteasor Kielholx

an the amphetamine sympenium.

best regatds.
Sinccrely yaurs,
Max

Fink,

M.D.

rrofesnot of Psychiatry

mil

�</text>
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                  <elementText elementTextId="103207">
                    <text>January 4, 1970
Dr. Allen P. Eorgar, M.B.
Associate Director
Pfizer Pharamceuticals
Grotoa Connecticut
Dear Allen,

Enclosed are tha

1573 for the study of thiothixene/
anxiaus suhjacts in the partial hospitalitation
program at our College. This atudy has met the ayproval of the
ralavnnt local cnmmittees and will be prasented to tha Resaarch
Coamittce at it: wanting later tits month. I believe the study
can begin as soon as the supplies art made available.

thioridazina/placebo

FD

1n

we will submit a
rtqutat for support for this study,
based on the anticipated completian cf 30
subjects before tha and
of the year, of $10,000, plus $3,000 for Sallega
overhead. In the
evant the study 13 not comglated, tbs suppctt will be negotiated.
Paymant 13 to be made at the and of the study.

Enclosed also are Farm

FD 1573 Gor the thiothixene
capsule
study in children and adalescants, following the protocol we submitted
soma aontha ago. It in my understanding that as seen
as it is
feasible, you will reconsidar the possibla use of thiothixane
1n
concentrate form in this study.

Many thanks for your coaparation, and
a successful 1970.

my

best wishes for

Sincerely yours,
‘

‘

'

c..d""

Max

.1231»

a
"
5'"

&lt;

w

awn

wrmumxe“

mlmpﬁwm

Fink, M.D.

Professor of Psychiatry

(“an

at]

�</text>
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                    <text>rww'... ,,__, ﬁwm..m.~.r—

y.-_m.

.

'm'v"m'-«w

,

.m- ¢t"

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. ~

‘

n ‘u

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.

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wrm

--.——v-.. m“

Iw'w—V4w-K

-.r‘..—‘,...

V

.7... “K "W...— ....w........._.

van-w”.—

January 5, 1970

--:~

-

g

Dr. Wilfred Dorfman
1921 Newkirk Avonue

E

Brooklyn,

New

York 11226

l

Dear

I

Bill,

E

time ago you asked that I roviow the volume by
"Clinical
Wittenborn,
Psychopharnacology of Anxiety". I regret
do
for so long~~ I guess I repressed the
that I neglectod to
it volume
found
the
less interesting than many othera—~
project since I
found
and
time
the
the result 10 enclosed. If it
but I finally
still interests you, please use it. If not, perhaps you'll try
Some

r

another.

My

best.
Sincerely yours,

:

_

.

”HIW'PV'NW",&gt;'IW—nvr

1'

.

_,

mun-,-

,,

Max

Fink, H.D.

a..." m,..-—_.w...__rw.“-.. ...v v

�</text>
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                    <text>January 7, 1970
Grass Instrument Co.
101 Old Colony Road

Quincy, Massachusetts
Dear Bob,

In order to provide for the play-back of some of our tapes
need, as soon as practicable, another Model 79 portable polygraph 9
particularly the chart drive, regulated power supply, oscillograph,(1),
I

and

signal marker.

I already own

For

a 7P5118.

until this

can be supplied.

me an approximate delivery date by phone.
come through the International Association.

checking and giving

The order
Many

will

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.v

.r—ynr

amplifier should be

this purpose, I would be willing to Obtain a used
if such is available. I would appreciate your

instrument

--

A-

The

I need this instrument as soon as practicable and if it can
be supplied sooner without the 7PSll, I can use one of the many

e—r

..-

Peterson

Mr. Robert

MF:kp

�</text>
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                    <text>E

E

i
E

E

?
F
E

r
E

E

January 7,

1970

National Institute of Mental Health
5454 Wisconsin

Chevy Chase, Maryland

Gentlemen:
May we please have three sets of application fbrms for
Public Health Service Research Grants.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 10,

1970

Editor, Calendar
SCIENCE

1515

Massachusetts Ave.

Dear

Sir:

Washington, D.C.

we wanid appreciate inclusion in the calendar of
a record of the next meeting of the American Psychopathological
Association, in ﬁaw York am February 13«lé, at the an York
Eilton Hotel, on the subject of " Mona Discréers“. Requests

for information are to be directed to the Secrataty,
at 5 East 102 Straet, New York City.

Max

Thank you.

Sincerely yours,
Ha: Fink, H.D.

Secretary

Finka M.D.,

�</text>
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                    <text>January 10, 1970
Dr. Wolfram Keup

EPRA

681 Clarkson Avenue
York, N.Y.

Raw

Dear Dr. Kaup,

It will be a pleasure, to have the abstract of my
ptesentatiau to the Hovembet meeting of EPRA, incluéed in tha
report of the proceedings, with the literatura citations.
I am taking the liberty of enclosing an announeamant of
the forthcoming meeting of the Amarican Psychopathological
Association, in Haw York on February 13~14. Since the subject
is can of intcrest to members of the EPRA, perhaps it may be
useful for us to circulate copies of the prograa to mambars;
or, at least, announce the meeting to those that may be interested.
If such circulation is possible, I will make copies a! the prograa

available.
EPEA,

I look forward t0 participating in the

and thank you

for the invitation.

activities of

gincarely years,
Max

Fink,

14.9.

?refesaur of Psychiatry

mf/

�</text>
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                    <text>January 13,
Dr.

Peter

1970

Kellaway

Baylor University College of Medicine
1200 M.D. Anderson Blvd.

Houston , Texas
Dear

Peter,

Enclosed is an abstract,”Lateralized EEC Changes after
Induced Convulsions,” of our presentation before the EAEEC
of 1969. The abstract sent prior to the meeting contains a
few errors wlich have been corrected in this draft. If the
abstracts of that meeting are to be published, would you
please use the enclosed as the text?
Thank you very much.

My

best regards.

"an?!

Sincerely yours,

.

Fink, 3.0.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>w—-w«

-

January 13, 1970
Dr. H. C. B. Denber

\.

Manhattan State Heepltal
Ward's Island
New

York, New York 10035

Dear Hy,

Enclosed are two copies of the report "Laterallzed

Changes

after Unilateral

and

Therapy” for inclusion in the

Bilateral Electroconvulsive
GWAN.

Sincerely yours,
Pink, “.9.
Professor of PsyChlatry

Max

Mszp

EEG

�</text>
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                    <text>«v.-

1:
oz:-

Wm

t5"

saw-wave

«w

vmmpa'u'wl

January 14, 1970
Dr. Roger P. ﬁnickel, Ph.B.

Professor of Phsrmacology
Indiana University

Meéical Sciences Program

Hall,

Myers

Room 360

Bloomington, Indiana 47401

Dear 9r. Maickel:

sent a copy cf ”Electrographic
Effects of Diacetylmorphine (Heroin) and Haloxone in Man"
for your consideration for the new journal ﬁgggppharmacq}ggx
0n November 5, 1969 we

and Psychopharmacolqu.

must be very difficult to liunch a new journal.
Nevertheless, we would like to ask whether this manuscript

It

is acceptable or whather
Thank you again

we

should submit

it

elsewhere.

for your invitation.
Sincarely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kp

�</text>
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