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                    <text>Irv-w" _.... . urnv'vlwmnrﬁ‘v'vm rmt‘ arm—a

e n’

}

June 15, 1970
H. Abelson
Science
Editor,
1515 Massachusetts Ave.,
Washington, D.C. 00005

Dr.

Philip

N.W.

Dear Dr. Abelson:
”Death from Heroin,” in the June 12 issue
of Science, highlighted an important medical and sociological
problem. The conclugion that two methods of treatment, methadone
and emotional support, seemed promising, omitted what may be
another exciting and potentially significant advance in opiate
Your

editorial,

dependence hiatOry

- that of the use of Opiate antagonists.

Coincidentally, the same crisis in heroin deaths spurred
antagonist data.
early May to call a meeting to review the New
York Academy
The meeting was hastily convened June 4, at the
of Medicine, co-sponsored by the National Institute of mental
ﬂealth. We regret we did not know of your interest in this
issue, for we would have gladly invited an observer.

us in

.

have prepared a summary of the meeting for your considera—
tion for publication in Science. The list of participants includes
the American scientists actively involved in clinical trials, as
well as pharmacologiata and chemists with interests in opiate
attended
antagonists. Industrial and governmental representatives
with
an
and hopefully, returned to their laboratories and offices
appreciation of this approach to opiate dependence.
We

Publication of this meeting summary in Science may serve to
inform others, unable to attend, of this progress, and may stimulate
additional research endeavors.
Sincerely yours,
WWWT.M

Max Fink, M.D.
Professor of Psychiatry

1

.v-‘mw

Hszp
811C .
NW“.

,

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                    <text>Wm—vwv

,

-

'~-

_.

June 17, 1970

Editor

Drug Research Reports
Washington, D.C.

Dear

Str,

For many years we have supported investigations
in the role of narcotic antagonists in the treatment of opiate
dependence. A meeting on this subject, attended by faculty from
various medical centers and industry, was held at the Academy
of Medicine on June 4. It was the concensua of the workers, that
the results of the early studies were much better than the press
had reflected, and that further study was ind eed warranted.
The editorial in Science highlights the lack of general
on the role of the antagonists or the results of the
studies. Perhaps, a small summary in your newsletter would

information

early
helpful in bringing this information to the attention of other
agencies of industry and government that may have antagonists that
warrant testing, or who face the problem in the community and
wish to be informed as to all the available methods of treatment and
be

research.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>June 17, 1970
Dr. Harold Meiselas

New

York

State Narcotic

Addiction Control Commission

1855 Broadway

New

York, New York 10025

Dear Harold,

regretted your prior committments
that precluded your attending the meeting on Opiate antagonists.
We have been encouraged by the latest editorial by
Philip Abelson
in Science to summarize the proceedings and submit these to his
journal for publication. A cepy is enclosed for your information.
Beth Al Freedman and I

Perhaps

we may

meet soon to review

this data.

Sincerely yours,
Fink, MD.
Professor of Psychiatry

Max

Mszt

�</text>
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-w—v,a..

«yr.

.
,2

....

1..

g.

y‘v-cmwt‘lmlﬂv-Anw

w:-

vva.ﬂw‘nmggr

'

‘

.

v

Z‘IIW‘M’W—aw,.W

June 17, 1970
'

hr. Fred Brunet
135

475 Northern Blvd.

Great Heck,

New

York

Sear ﬁr. Brunet:
want to thank you for your prompt
maintenance on our IBM 1800 System.

I

attention to our needs

I was as startled as
been made since
had
cells
you that no preventive maintenance
issued
October 1969 and that none of the engineering changes
date.
same
the
by IBM Had been installed since

for

In our meeting with

Mr. Bull on

6/16/70,

we

agreed that a

would be made on 6/22, and bi~weekly thereafter until
were indicated.
we were assured that less frequent calls
responsibility.
PM

call

Hrs. Traynor of

my

staff

was

assigned the liaison

ﬁr. Bull indicated that there were 15 hours (approximately)
parts and as soon
of EC required. He has requested the necessary
to be installed
these
for
as these are assembled he will arrange be done no later than 6
on week—ends. I assume that
weeks hence, about July 30.

this will

the frequent pattern
also shared our anxieties regarding
we
were assured that
and
of downrtime after EC's are installed,
plus croesnchecking
diagnostic
all EC's would be followed by full
We

against our running programs.
in this purchase and
I am most grateful for your cooperationdetails
of this significant
in assisting us in the many administrative
re-arrangement of our relationship.
Sincerely yours,
Max

Fink ,

3‘10 D u

Professor of Psychiatry

HF:kt

cc:

2%?)

'5:

Dr. D.

miner
M.

Shapiro

.w.w("vl'

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                    <text>June 17, 1970

Editor

Drug Research Reports

Washington, D.C.
Dear

Sir,

For many years we have supported investigations
in the role of narcotic antagonists in the treatment of opiate
dependence. A meeting on this subject, attended by faculty from
various medical centers and industry, was held at the Academy
of Medicine on June 4. It was the concensua of the workers, that
the results of the early studies were much better than the press
had reflected, and that further study was ind eed warranted.
The editorial in Science highlights the lack.of general
information on the role of the antagonists or the results of the
early studies. Perhaps, a small summary in your newsletter would

helpful in bringing this information to the attention of other
agencies of industry and government that may have antagonists that
warrant testing, or who face the problem in the community and
wish to he informed as to all the available methods of treatment and
research.
be

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>June 23, 1970
_

”Ml’v:

8*-1‘1'

5-2

4

Dr. Lois Chatham

National Institute of Mental Health

5454 Wisconsin Avenue
Chevy Chase, Maryland

20015

”was"

um.

Dear Dr. Chatham:

4—.

mum-mu:

nun

:MW

I am pleased to enclose a copy of the program of the
Special meeting on narcotic antagonists and a summary which
we have just prepared for Science,
We

have just expanded our cyclazocine program in a

full clinical trial, hoping to treat 100 addicts in the next
twelve months. While this number may not be large, it does

of our ongoing program from a research
We will be seeking a way of
insuring an independent clinical evaluation, and I will bring
the NARA recording to the attention of Dr. Freedman.
represent

an expansion

model to a.demonstration one.

My

thanks for your patient and thorough explanation

of PL91~211.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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                  <elementText elementTextId="105898">
                    <text>“1,”,7,”

.__,

,.. .._.,..r

.

.,

"um.

..

7.,w‘Jg 7W a V...”

r M-

3.71.1.1v-71 sung-n.1,

1

.1

1.1,.

inquu‘wﬁ‘rw,, ..

1,,.-cv:-:.,,r

1h

.wwxum~r:mwrr ‘gt‘cwmuew‘kwrﬂ‘ W"

w‘uué

vmwa-w

June 23, 1970
Dr. G. F. Blane

Reckitt &amp; Colman
Hull, England
Dear Dr. Blane,

?

?

and

I look forward to meeting you on July 15;
will arrange to meet either in the city or at Kennedy

airport, whichever is
Hay

L

g

most convenient

for you.

I suggest you call me on July
? I can be reached:

to confirm a time and place
0700—0830

13

1900-

516 466 5444

(home)

1000-1730

212 369 8488

(office)

I look forward to your

visit.

Sincerely yours,
Max

mf/

Fink,

M.D.

or

14

-,.~,..

_

“u. .~,-~

,,.

-~ww-~

&gt;,ay-w-

r‘w‘-'.n&lt;-r'M-Vnm

.1.

r

IPZMF" 1”

�</text>
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                    <text>9 upyal-rl'xn

-

,n,.,,.c‘.,(“v.19

ﬁrm“,

LN}.

“J’mefw—zﬂwy..ww :i-w

I

_

A ‘rj‘ru'

'-

-. :7"

,1...

»

.

x

,

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~v,«

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v'w

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23-

~-' v

June 23, 1970
Dr. Sudheer Gogte
3/37 All India: Institute
of Medical Sciences
New Delhi 16, India:
Dear Dr. Gogte:

Separately I

am

sending the reprints you requested.

Our college has a formal course in pharmacology leading
Ph.D. degree. It is not a clinical program however, In
this country, the clinical programs that are well known are at
Vanderbilt University (Dean, School of Medicine, Nashville,
Tennessee) and the University of Michigan (Dean, University of
Michigan School of Medicine, Ann Arbor, Michigan).

to a

you the

I have asked our Director of Residence Training

applications requestdd.

to eend

As to the cyclazocine report, we selected imipramine
failures since: (1) cyclazocine was an experimental treatment;
(2) the only justification for its ethical application lies in

trials

in those

We

who

fail other treatments.

have discontinued these studies because cyclazocine

is no longer available for experimental trial in depression.
It was concluded, that despite its antidepressant activity,
cyclazocine was associated with sufficient secondary effects

as to preclude its usefulness in mass trials. We are interested
in homologs of cyclazocine. ﬂow, and these should be brought
to clinical trial in the next few years.
Thank you

for your careful inquiry.
Sincerely yours ,
Max

Fink, M.D.

Professor of Psychiatry

Psinkk

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                    <text>« «aw—Wm “‘"1H-3y»

"

‘“

‘

~‘

'“"‘

"*‘V‘rvr-ﬁ~é“r*~"'v--*"’r"

‘&amp;

'W

--u.—.

‘w

&amp;n~‘1-Ir:"'.9¢'~‘-WH-

,

,-&lt;.v—w.‘:r.-m-~«M. EEW'rv—W' u.‘

,7

.
.n
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.
_

v

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.,
.

1

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,
w
hm . w . 'ry4.‘.::,
.rn.‘ -1...“
,

,

June 27, 1970
Dr. Jonathan 0. Cole, M.D.
Boston State Hospital

Boston, Massachusetts
Dear Jon,

It is a pleasure to respond to your questions of the
of
to recognize heroin and to distinguish its
post—addicts
ability
effects from other compounds. Our data may indeed be relevant.
In a variety of studies, we have administered heroin
(15 to 25 mg/icc/Z minutes), saline, cyclazocine (0.2 to 1.0 mg/Z cc/
2 minutes) and naloxone (0.4 to 1.8 mg/Z cc/2 minutes) to post-addicts
(3—20 days after last doses of methadone) and to subjects receiving
chronic oral methadone (100, 150 and 200 mg] oral/day).

addicts, between 20 and 35 years
of age, with histories of opiate use for at least 2 years. Our sample
consists of 35% Puerto Rican and 50% negro. They are voluntary admissions
to Metropolitan Hospital and their cooperation is obtained for these
experiments by indicating that these teats are necessary as prerequisites
to chronic maintenance therapies with cyclarocine or methadone.
The studies have been in progress for 4 years, add in this
time we have examined more than 100 subjects in more than 400 experiments.
The

subjects are

young male

Based on this experience, I believe the following conclusions
are applicable to your questions.
1. Can addicts recognize heroin, given intravenously and

double blind?

Post-addicts have no difficulty in immediately identifying
They make occasional eraors with 15 mg, indicating a
difficulty in positively identifying this quantity. They identify
cyclazocine as a noneopiate substance, and naloxone has always been
called a 'blank'.
25 mg

.
"urn—rmri

«mo-a-

heroin.

..
—,

u:

vl—‘W'I-r-u‘,"

Am

..

-;~,-.

‘.‘;-W'V!

«ﬂy-1.

r-p

.4.

,.

any“...

'Ivnr'i’vw

1

-

Subjects receiving 100-200 mg methadone daily, cannot
identify 25,50, and 75 mg heroin for up to 48 hours; thereafter they
rapidly identify the small doses of heroin, not only by direct heroin

effects, but

hours.

by the

relief of

withdrawal which

is present about

48-60

,
«Yo—am.

an.“

:y:

u--.“

.m

:

�For post-addicts and methadone subjects after 60 hours,
the administration of heroin is accompanied by a sequence of experiences
described in such a ritualistic fashion as to make us believe that the
effects are commonly experienced. The subjects are tense as the injection
is first made, and after 1.0 to 1.5 cc, they relax, smile, and tell us
that this 'is it': they feel warm 'all over'; and within 2-3 minutes,
are comfortable, drowsy, cooperative and tell us that they are 'high'.
u

,umv

—~

—,

sequence

is

no good', and do not become drowsy.

‘Arw¢v.4w1v‘m~4rv—|

r

is

a placebo, nsloxone, or cyclazocine are given, this
not apparent. They remain tense, complain that the 'stuff
When

our

For the patients who have had morphine, they tell us that
does not feel like morphine since they lack the skin tingling

stuff
is characteristic of morphine.

which

I would conclude, that addicts can tell 'good stuff' from
The amount necessary in our subjects is 20-25 mg. (The
clinical effects are accompanied by characteristic EEG changes; and in
the methadone treated subjects, bedore 48 hours, the EEG effects are
indeed absent, as are the behavioral effects).

the effects.

2. Our addicts can discriminate heroin from the substances
above.
They can also tell heroin from alcohol and barbiturates,
indicated
am
if I to believe their reports, but we have never made direct experiments
along these lines.

v‘

r

m'wmm

r
w.

.un'-q-I

u

.

distinguish

I have never tested the ability of our subbects to

among

I
specific
posed them, I
may be useful

have

While I do not
data to answer the questions posed in the way you
will send the reprints and preprints available, and these

I‘M/r.

If

mr'

mumpwr

-

opiates.

trust these responses are helpful.

in supporting your evidence.

it

your presentation.

is of

any help,

we

can be

available to support

/:u4-w~

A"..W5w31r.lp'-

best regards, and I do appreciate the Opportunity to
answer these interesting questions.
My

«-

w

xv

,
‘mm

Sincerely yours,

v”:

'A

vvw—w

JD'WﬂI'W

Fink, M.D.
Professor of Psychiatry

Max

yam-v

ov-nrw'wnrvv

.
nun-s.

n

-..
‘
~

”army-n:

mf/

�r Zwm'jiﬁhzx'n» ”w“

.

.p—

--. -mpmmu

,

as.

.,_.,.

June 24, 1970
Dear Costas,

Finally, I have very good news ! During the past
month, the grants management staff of the N.I. M. B. have met
with me on three occasions; each time we resolved another problem
and today, they signed a contract allowing us to undertake the
study we discussed more than 15 months ago. The problem of
cannabis is still acute, and despite many new studies, there is

still

confusioin about the possibility of chronic effects.

The contract permits the International Association
subcontract
with
scientists in Athens to study the problem
to
of the chronic effects on brain function and behavior of cannabis.
The goal is to study as many men as may be found who have been
taking cannabis regularly for extended periods; to measure the
degree to which brain dysfunction may have occurred; to undertake
acute experiemnts, in which the EEG, memory and perceptual changes
of cannabis smoking may have an effect and to record the changes,
with analyses completed in Athens or in New York. We are also hoping
to have supplies of cannabis from the men themselves, with portions
smoked and others analyzed in your laboratory. In addition, we
are permitted to ask that some THC be extracted and tested in
these clinical trials.

I do not know how much can be done. The original
been
has
accepted, with few modifications. It seems
protocol
best that I arrange to meet with you during my forthcoming trip
to Europa, and that a more definitive protocol be worked out;

particularly one in
proper

staff

which the work

is detailed

so

that the

can be recruited and a work schedule prepared.

Dr. Freedman will also be in Europe this August
and I hope that he will have an opportunity to meet with you
and discuss his goals for this project. Unfortunately, I do
not think I will be in Athens at the time he may be available.
As my

plans

now

stand, I will attend the Turkish
in Athens from

C.N. P. meetings from August 17 to 21, and can be
the afternoon of August 21 for the next few days.

If that is

not satisfactory, I could take my family to Israel for
and arrive in Athens August 25-27.

some days

We

look forward to working with you, Dr. Stefania

My

best personal regards.

respective associates. I hope that we will be able
contribution to the definition of the problem of
the effects of cannabis.

and your

to make a

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>,.

ww- .

WWW-”1|.“r:-.--_-n;.T-.--

_~,_3

.

'

"WWW
&gt;

,

~

,

,

»

‘w-w “WWWIWWWIM gym—saw» .mw.~w-»wv-at”- 1,... .M V ,W "wt.

‘,__,_,

“f,

V”

.,

..

,.

.
.7—

,

June 28, 1970
&gt;‘nm’mvvmwv'qlmev-wun

Dear Dick,

-—m’n-w—Mn~w.mqr‘u

«4

r

With reference to the
for membership:

ACNP

request regarding nominations

I would like to nominate two of my associates, whose
work is well known to me, and who will be able to make significant
contributions to the College:

1.:“unwm

Jovan Simeon, M.D.- Assistant Professor at the
New York Medical College. He has been working with me since 1966,
and is now a project leader, working in adolescent and child psychopharmacology.
Ali Keskiner, M.D.— Associate Professor, University
of Missouri, St. Louis. I have known his work since he joined
the Missouri Institute of Psychiatry in 1965. He is an independent

investigator in schizophrenia, with particular interest in rehabilitation

-

..

wrwnr.

as

it

is enhanced by psychoactive drugs.

In addition, there are three young men at this College
independently and should be candidates in the
are
next few years:

who

now working

Richard Abrams, M.D.

Arthur Zaks,

M.D.

Richard Resnick, M.D.

Dr. Keskiner

have already seconded the nomination of
year; and will recommend Dr. Simeon next year, if

I believe that I

this

this is permissible.

Good luck

!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

I

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                    <text>June 28, 1970
Dr. Albert Kurland
Maryland Psychiatric Research Center
Baltimore , Maryland
Dear Al,

It was a pleasure to visit your research center yesterday,
and I was very impressed with the progress that has been made
last visit a

since

my

Clint

Brown.

few

and you have assembled an

I

am

enclosing

years ago.

exciting

"s

“w“...-

that there are

.ﬂ‘m.wﬂ

you and

for

ECT

this instrument for quantitative

-v

reports for

With regard to the PDP~12, I would like to reiterate,
many programs that have to be written in order to use

.r‘r-p'vmn‘ri-A-

WG‘mWaN—umxﬁu?

and

very fine

project, I am sure that we will be
able to assist in the analyses of the EEC data, provided the information
is collected in a form compatible with our equipment. For Clint's
information, we have l/2 inch, Ampex SP 300 7-channel FM equipment.
As soon as I have a change
to review the protocol and obtain a
clearer image of the amount of data to be analyzed, I will be able
to submit a more detailed suggestion.
With regard to the

,,

reprints

some

facilities are

The

group of co-workers.

EEG

analysis. If the various users

ﬁéfiuﬁocéﬁdﬁeﬁiﬁé§ ﬁeeﬂﬁéﬂld be possible to obtain the services of
igédigﬂﬁtbﬁgcﬂdffiifeHﬁfﬁﬁpcﬂoC§H§f§t in the programming. In addition
ﬂo'tﬁd Eaﬁiﬂfﬁants listed in Don Klein's letter, I would be pleased
to have my associates provide you with a bid on the system that may be

useful.

3"”9 383 I630

My

thanks for your kind invitation and

hospitality.

.
.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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              <elementText elementTextId="43773">
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                    <text>r'

wan——

7.

m

'

.

:4

.mwn-w—ww-onmxmnmmw mum-w W‘x-‘Iv‘r—V'Wﬂurm

»

~~m~

m

"—-

.,

”ﬁr ”wry“. m“. .mwm. V.m._...,,.vw-

v-wmﬁorf‘

June 28, 1970
Miss Bernice RoBerts

Lilly Research Laboratories
Indianapolis. Indiana
Dear Miss Roberta,
Your request to the

Missouri for a copy of

Psychiatric Research Foundation of
sent to me for reply.

PRF 66—1 was

Unfortunately, the supply of this report was exhausted

some months ago.

In the event that the scientist requesting the information
wishes to write regarding the details of that study, we would be pleased
to hear from him at my present location.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>“a

—

-

a

”A... m...

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.gwwqms

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(W's.

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up

June 28, 1970
Dr. Russell Taylor, M.D. Ph.D.

Philadelphia General HOSpital
Philadelphia
Dear Russ,

If I understand your question, there is a proposition
before the
to develop a certification in clinical pharmacology
A.M.A.

by the American Board of

Internal Medicine.

For those interested in the clinical pharmacology of
affecting the central nervous system (or other systems
not ordinarily considered part of internal medicine as eye and
skin), an examination as part of the Boards in Internal Medicine
would be unsatisfactory. I believe clinical pharmacology to be a
derivative art, and not limited to internal medicine, being part of
each subspecialty.
compounds

Certification in clinical

pharmacology by each of the
be
but
this would be unwieldy.
considered,
may
would
serve to upgrade the discipline, however, and in Psychiatry
It
the development of an examination in child psychiatry has apparently
done much to improve the training in this specialty. If there
is a need for upgrading and certification, I would tend to favor the
model of child psychiatry, rather than certification in one board
only (e.g. ad internal medicine) or even the development of new

specialty boards

specialty or a conjoint board.

It is

a complex qyestion and

opportunity to expeess these views.

I thank

you for the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
Mr. 11 B. Schwartz
TO'

Max
FROM:

Fink,

June 29, 1970

DATE

M.D.
SUBJECT

attached

memo

Please request honorarium of $50.00 to be issued to Dr. Sarnoff Mednick,
2 Perry Street, New York, New York 10014.
This should be charged to
Research Training Funds and is for seminar which he presented on
April 14,1969.
Thank you.

mm:

Kﬁ}’:i

2X5

�</text>
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«v-

'm’m'l""

rwr—U‘

June 29, 1970
Miss Irene Jeryn

Hospital for Sick Children
Toronto Canada

Dear ﬂies Jeryn,
Your recent request to the Psychiatric Research
Foundation of Missouri to purchase a copy of PRF 66~1 was referred to

me

for reply.

Unfortunately, the supply of this report is exhausted, and

your order cannot be

filled.

In the evnt the

specific questions,

we

to the address above.

scientist requesting this report has

would be pleased

to anauer these, addressed

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>L.=i-r..

;

;

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a»

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w

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ma.vr;\r.:§ll“§llrpVy-1n'wua’l'7‘0

June 29, 1970
Br. Jorge Garzon

83-30 Victor Avenue
New York

Elmhurst,

Dear Mr. Garzon,

I am pleased to accept your invitation to present
of our data on the EEC profile of doxepin. For purposes of
reference, the following are pertinent.

some

I am Professor of Psychiatry, New York Medical College;
and the Director of the Division of Biological Psychiatry of the
Department of Psychiatry. I have been at this college since 1966.
Prior to that, I was the Director of the Missouri Institute of
Psychiatry in St. Louis and Research Professor of Psychiatry at
Washington University (1962—1966); and the Director of the Department
of Experimental Psychiatry at Hillside Hospital in Glen Oaks, Queens
from 1954 to 1962. I graduated the New York University College of
Medicine in 1945 and an certified in Neurology (1952) and in Psychiatry
(1954) by the American Boards.
Thank you for the

invitation to participate.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

gum-mour

,

777,—..."

,

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I read thebaselinseofeﬂhbdbodprogedﬁqnnanaboxonilﬁniyeur 933
issue with some surprise and unease, for it is filled with
important errors. An earlier report, alleged to come from Washington,

June 24
was

(AS

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snub) Jroqsr aid: in soruoa 9d: Jed: Jeoggue 03 has .bsviovni asueei
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Depardienﬂioﬁﬁlsydhilbri bﬂvthebﬁeldtdsbIﬂqétcoﬂJCubldgd,.ludanOIesggue

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.eetwrsdjo uiurj are 83953 ed: nsdw ,snnshnsqeb ensign almonds n1
2. The program for the study of neloxone is under our joint

directionﬁm ti sort-opporudonyzfnndsoosdchethlomdtitute of

Mental Healthdnvhd hiltigrostinoddestodcanannppsesed aseltbcsstedyslawsn
of antagonists was in 1968. Since then we have been supported by the
New

York State Narcotic Addiction Control Commission

of narcotic sntagoﬂisbs.rfsxsant?

in these studies

In the spring of 1969 we did recommend a program for
the development of a long acting naloxone in silastic vehicle to the
National Institute o£.ﬂendnldﬂeshth, requesting a contract. That request
has never recordedaﬂ iorsatesapiﬂ, although informally Dr. Cohen has
indicated that the Institute has another program that they are supporting.
3. Endo has an

they are awaitin approval.

NBA

for

Narcnn

for acute intoxication.

snd\3m

Since 1967, four investigators have received supplies of
naloxone for trial in Opiate dependence. Three have assayed more than a
few patients and these attended the conference on Narcotic Antagonists,
sponsored by the National Institute ofMental Health and our College,
held at the Academy of Medicine on June 4. It was apparent at that
meeting that more study was necessary before oral neloxone would be
useful in the treatment of opiate dependence. Suggestions that the data

for this application are satisfactory for

an

NBA

are premature.

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investigators at this

meeting that further studies be undertaken, of the clinical applications
of antagonists (particularly naloxone and cyclazocine) with concurrent
attempts at the development of long acting forms, and trials of other

antagonists.

lnfortunately, supplies of naloxone for clinical trials
We requested additional supplies in December 1969,
and despite many proﬁﬁiﬂs,8€hoanthave not been made available, and
it is unlikely that they will be available in the near future. We have
been advised, informally, that since Endoahaaquthasaadﬂvgaidn.aﬁalbﬂ
DuPont, the review of this program by their officers concbudednbhgnldesw
the supplies of naloxone should be reserved for the NBA uses (i.e.
acute, parenteral use); and that since there was no market for aura 159a
antagonist in opiate dependence, all support for this program, including
the mklahilhbxodﬁnsnpphsaonhedurﬂeincubateded: baa-1 I
are in short supply.

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I am writing these notes in two attenptsﬂjta bbdttfyoeha
issues involved, and to suggest that the source of this report (June
and tbdjptevhmkndpobns mamacbabhaabootﬁonlﬁda the accounts

asw

24)

Suggestcdnhbna,,bgbldnDtﬂlatbphidabﬂbu.ﬁduﬂivad QIOIIﬁerﬂeﬁorhnsﬂbcsqu

Endo is supporting the program for assay of naloxdﬂl
in chronic Ipiate dependence, when the facts are truly otherwise.
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io azunnmﬁoD-npenausedthaootbenirquotuxamearing in tourmaline-11b
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9d: yd bsjroqque 599d svsd 9w ﬂed: eonla .8891 nl sew ejelnogsins 30
eolbuie seed: at noteatmmoO IcijnOD nolsolbbA alioorsK 93838 ﬂxoY wsH
Sincer81y.)outaogsins alnoorsn 30

report implies that

101 margorq s bnemmoosr bib 9w QBQI 30 entree ed: nI
on: 03 elatdev aljaslle nl snoxoisn gnljos gun! a lo ansmqoievsb 9d:
jasupsr 35dT .3osrjnoa s gnljasupsr ,djﬂanHFilhseH.ho sjujlaenl Isnoljsﬂ

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s and:

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,ajalnogsjnA alsoDIsM no eonerslnoo 9d: bsbnsjjs seed: has enaelieq we}
,sgeiIoD ruo has djlssH Isnneﬁlo ejujijenl {Bookish ed: yd bsrosnoqe
33d: 33 insunqqs saw 11 .A snuL no onlolbe” lo vmsbsoA an: is bled
ed bluow snoxolsn I510 stoled viseasoen asw vbuje 930m 35d: gnlnssm
sash ed: 35d: enokaeenguz .sonsbnsqsb ensiqo lo jnsmsssrn 9d: at Iuiseu
.szunemerq era AGM as 103 v303oslal3se are noljsothqs 21d: :03
970m

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                    <text>'I=‘"ur'

. "V“IW‘Wu-VIW'WMU‘

wan-w "~'rr.rw, "I‘m-swarm

W1. --.-.v- ww-

.

W:M.w——mm :rlrrli’

*4 ,

alc‘l_~hs’1.\‘&lt;x.

.

WI‘VV'~'ym"~w~p'm"twp,“

. ~N'xvu"

»=»-'D

w inn-.3..-

~.~.:.—,-;u-—.v—m.~.»»,

.4“,-

June 29, 1970
To Whom

it

May

I

Concern,

pleased to endorse the application of
membership in the Central Association of
Itil,
Electroencephalographers.
Dr. Turan

am

for

rue-m.

»

w"

wr-m‘w—

Anvme-H'mW-erw

mo:

v

I have known Dr. Itil since 1958, and have been closely
associated with him in his research programs at the Missouri Institute
of Psychiatry since 1963. In the programs which he developed
there, Turan has shown an unusual enthusiasm, ability and integrity.
His approaches are novel, and his technical ability exemplary and
impeccable. His work in the EEG effects of drugs, in sleep research,
as well as the applications in the special problems of therapy
resistant schiz‘phrenia and clinical effects of new drugs are among
the heat produced in this country in the past decade.
knowledge

society.

I

that

recommend

he

will

his application with enthusiasm, with the
outstanding contribution to the

make an

Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

un, ..

v.

'v' :7

r :

‘

~,—-~.ku,»-—"-.~«- m

..

7.»

Inf—

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"m,

vaw’,

my

.m.

W-vauamvn'gu'arwdwvg

u

"»m:ﬂ~1w~rr.;-;K‘FKI’FT'I‘m-rml¥-OF‘VNMW'NVw—ra-r,‘Irv—"MT“;

w u ‘,-'r"1-- "The
-

7.

»

—

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A

»

;- my..-

June 29, 1970
Mr. George Griffenhagen

National Coordinating Council

Washington, D.C.

on Drug Abuse Education

Dear Mr. Griffenhagen,
Thank you for your kind invitation to participate in
the July 15 meeting at the Chalfonte Haddon Hall in Atlantic City.
As I anticipated, I will be unable to attend, and I have asked Dr.
Richard Resnick of my staff to present our data.
Dr. Resnick is an Assistant Professor in this Department
and has been a project leader responsible for our studies of cyclazocine
since 1967. He has developed a typology of characteristics predictive
of outcome in antagonist therapy, and has been able to deliver a full
cyclisoeine induction in 4 days with minimum symptoms. I am confident
that he will most ably satisfy the needs of the panel, and I am
sending him the material you sent me. He can be reached at the above
address or by telephone at his office (212 MO 2 1899).

Again,

my

thanks for your invitation to

this interesting panel.

participate in

Sincere;y yours,
Max

Fink,

M.D.

Professor of Psychiatry

"-

'W-w

“vvwwm. .mu—mww. w... J”). gnamgﬂmnw-w‘wr-w

mf/

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,

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�</text>
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                    <text>June 29, 1970
Dr. F. E. Shideman
Department of Pharmacology
University of Minnesota Medical School
Minneapolis, Minnesota
Dear Dr. Shideman:

I am pleased to recommend Mr. Peter Irwin as a candidate
in your doctoral program. Mr. Irwin has worked in this Division
since January 1968, and during those years he has assumed more
and more

responsibility, exhibiting industry, reliability

and

enthusiasm in a research program for
little training.
has learned how to record and process the human EEG; to use an
IBM 1800 digital computer and auxiliary electronic equipment; and
which he had

He

to record and analyze
In

assumed

human

behavioral data.

this work, he has been reliable

and capable.

He

responsibility for analyzing behavioral data of

has

considerable complexity and approached the problem with
interesting and novel methods.

I highly

his additional training,
without reservation.

recommend

to your program

and commend him

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

�</text>
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                    <text>WW‘Z’

:v-unv m .mrw-ww’.

"K‘Jru'n'.

mmquswnmW‘s—w.«a wr ywlm.""x’0wvn :
I ~

arm

“aux-.-

».-

nu ma: Iw-B'WF&gt;IS:- m. 1" V

-

.uuv.» vum-m-uuan

-

yws—u—w—v-wwww(.mqanryump-u;

(us-W,

v
r—‘Vy'rmx14‘r'nvvm‘w"~»~uw:w~.wn‘mxﬂ]uv""r“l.wvn‘

June 29, 1970
T0

WHOM

IT

MAY CONCERN:

psychiatric assistant

Mr. Robert Sharp was employed as a

in the drug addiction research program of this Department of
Psychiatry from October 1967 to April 1970.

During this period he assisted us in interviewing patients
with opiate dependence; supervised other assistants; participated
in group therapy sessions; and coordinated ward activity programs.
In these efforts he was diligent and reliable. He assumed
responsibility and carried it out.
he

left

us for personal reasons, wanting to be with family
I regretted his leaving, indicating that
California.
in
could have his position back as long as it was unfilled.
He

members

I

am

pleased to

recommend him

for

a

similar position.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>.

l:

May

l,

i970

Dear Oldrich,
have received our proposed program, and I
has been accepfod. i am wrifing foday To ask your

By now, you

assume

it

approval of supper? for

pr

of The parilclpanfs.

Drs. Davis,

requesied supporf. Dr. Griffith
has some aid from his unlversify for his slay in Prague, but
Dr. Oswald requires
should be awarded $400 to aid his Travel.
Friedhoff

and Ladewig have no?

fare lo Prague,

and should be awarded $200.

Will you write To These men,

Philip Bradley?
Many

Thanks, and

i

or,

may

i, or

should

look forward #0 seeing you in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF :

kp

air

�</text>
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                    <text>ﬂay

i, |970

Dear fir. Refer: :
On

ihe advice of Professor Danlal Efren 0f fhe National insilfufe
i am
adﬂresslng lhls lefler f0 ask whefher your

of Manfal Healfh,

laboraforles

can produce

clinical quanfilles of Naioxono,

narcnflc anlaganisf, for our sfudlas.

a

Naioxone (l~n~aliyl~7,8-dlhydrn—l4~hydr0xynormorphlnone
hydrochloride) is useful in freatlng
dependence,
but The clinical irlals have been law,opiate
llmlfnd by an lnadequafe
supply. As l understand the problem, naloxona is produced from
Thebaine, and if is The prescription of lhls compound which
curfalls

producllon.
We

have found That 3.0

oral naloxone a day are naeded +0
and would lika f0 verify fhis
observation in a clinical lrlal. wﬁ need 2-4 kilograms naloxone,
and i am wriflng f0 inquire whether Maker Chemical
produca
lhls cempcund in fhis quanfify; and if 30, a? whaf can
and in
ccsi
whai lime. WE are capable of wrlfing a
contract
60 days,
wilhin
and wmuld hmpe lo d0 5G as soon as a bid is received. While
is on fhe narcoflc iisTs-of This caunfry, we have haen assurednaloxona
nf fhe necassary impart llcansas; and as fhls supply will
net be
sold, are assured of fhe coop@ra+lon mi The licensee.

sustain antagonism

i

To

Gms

cplafes,

look forward To hearing from you.

Sincarely yours,

m1wwarumw.

Max Flak, M.D.
Professor of Psychiafry

Mfzkp

cc: Dr.

A. M. Freedman
Dr. 3. Efren

“‘th-

r
-

7.-:I.k.-a

AIR LETTER:

Dr. Z. Rofen

Direcfor

Chemical Lfd.
6570

MAKOR

PO

Jerusalem, lsratl

f
my!

SW!)

15%

‘

-.-an

�</text>
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          <element elementId="48">
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              <elementText elementTextId="43653">
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                  <elementText elementTextId="105887">
                    <text>‘

ﬁ

f. ‘1

May

Dr.

W.

4, i970

Douglas Skeifon

Emory University Clinic
Allanfa, Georgia 30322

Dear Dr. Skelfon:

Enclosed are some of our recenf reprints, including a copy
fhe
of
Q-scale reporf. The fechniques‘for cyclazocine are
described in sufficienf defali To be useful. Cyciazocine can
be ob+ained from Sferling-Winfhrop Laborafories in Renssalecc,

New

York.

Naioxone is no?

available for Trial.

can "fune in" cyciazoclne by using the scale and
inducfion schedule, and as pafienfs are in Treafmenf, reviewing
These wifh us. We would be pleased To have you visif us, or have
one of us consul? wifh you in Allenfa if you wish.
You

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF:kp
GﬂC u

�</text>
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                    <text>~

~wm-n-.v.mwvm"‘m-Wssmw may...

. “0.:

.m:mu.-, .‘wuyn—Ig J‘JI'WC'mmm-

.

-

,

7

May

u

g

,

.vur y'arth-‘g-Wg ;7~‘,.‘..W,»Wmlmn,— rvvv-v

4, i970

Dr. Maurice Seevers
Univarslfy of Michigan
Deparimeni of Pharmacology
Ann Arbor, Michigan
Dear Dr. Seevers:
in a leflar from Dr. G. F. Blane of Reckiff and Colman
describing sfudles wifh narcoilc anfagonlsfs, he menflons
320*M as an inferesilng cempound 3? Michigan Unlversiiy which
failed “To prolacf dapandenf monkeys againsf sympfoms of
morphine wlfhdrawai”. i presume the work comes from your
laboratory and would appraciafe your raferring This nofe +0
fhe appropriafe co-worker for any pre~prin+s Thai may be

available.
Many

+hanks.

Sincerely yours,
Max

Fink, ”.0.

Professor of Psychiairy
MF:kp

-x-.-—_

'.-‘:V

-

‘ni‘Vm‘mﬂ‘m'n

~

,
-..;,-

'v‘

u:.~muu.;.~—~,,vvy—«ww‘w-m.w:mmgmmvw

.v

,

.,.

.

�</text>
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May

Mr.

4, 1970

Harberf Sfurz

Vera lnsTifufe
30 Eas? 39+h Sfreef
New York, New York
Dear Mr. $+urz:

‘n reading The lafasT WHO reporf of 1+5 ”Expert Commiffea
on Drug Dependance”, concerning ifs l7fh mee?lng, Augusf 25~30,
1969, ! nofed commenfs which ara ralevan? To our lnfaresf. I
am Taking fhe liberfy of sendtng you fhe anglosed pages (24-26)
of who Technical Rﬁporf #437, Geneva, 5970.

Sincerely yours,
"an Fink,

#900.

Profassor of Psychiafry

Mmkp

enc.

�</text>
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                  <elementText elementTextId="103300">
                    <text>33?"

'3‘ wr-rvmmumu‘nmmn‘w.“ﬂ

-...-,

,

-

w

«lax-war

May

Dr. G. F. ﬁlana

Clinical Research
Rackiff

&amp;

Calman

4, 3970

Co—Ordlnafor

Dansm Lane

Hull, England
Dear Dr. Blane:
Thank ycu

for your reply

To my

inquiry about

SOBO—M.

are lndeed Inferesled ln Gaveloplng a long~ac+ing opiafe
anfagonlsf, and if some clinically usable supnlles of 5050~M ware
available, would be wllling To underlake or underwrife The Tesfs
nacessary for an lNDA.
We

I

am

no? acquainted wlfh 320~M, bul will Try To obtain lhe
which i presume comes from Dr. Seevers.

available dafa,

leek forward +0 gafflng logefher in July in New York and
ask fhaf you write as soon as your Trip plans are crystallizad.
l

Slnceraly yours,
Max

Fink, M.0.

Professor of Pchhlafry

Mszp

.m

.,r

awry-u

warms;

w

.A,

mum-nay”;

"fully”

A

.

.

*wzmmnnrr'“

�</text>
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                  <elementText elementTextId="105884">
                    <text>T,,.

.14,

,_

“mm, ,

-~

NJn-na-nmnrrrw

mirrﬁh—iﬁwvm

wuaqﬁaﬂ

wwwwzmm»ww "W"

4, l970

Universily Clinic

Allan+a, Georgla 30322
Dear Cr. Skellon:

Enclosed are some of our recenl reprlnfs, including a copy
of fhe Q~scale reporl. The Techniques for cyclazoclne are
dascrlbed ln sufflcienl defail To be useful. Cyclazoclne can
be obfained from Sferlingnwlnlhrcp Laboraforles in Renssalaac,
York. Naloxone is no? available for Trlal.

New

You can ”lune ln” cyclazocina by using fhe scale and
lnducfien schedula, and as paﬁianls are in freafmenf, revlewing
fhese wifh us. We would be pleased +0 have you vlslf us, or have
one of us consul? wifh you in Allanfa if you wish.

Sinceraly ycurs,
Max

Fink,

M.D.

Professor of Psychlafry

"r.

1‘

.

Dr. w. Douglas Skelfon

Emory

'M.

v

.rrw,» “a“, ,.

May

«y-

.vwvnvx-my.

1,3;

NF: k5)
GHC.

�</text>
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                    <text>May
7

,

arc-n...

u

ralY‘Zer-Ifr‘ﬁ

Mr. D. A. Geickle

Secretary, Commiffee

CMA

House

i3, i970

on lnformafion

'

|867 Alia Visia Drive
8, Canada

O++awa

Dear Mr. Geickle:
Dr. Lionel Soliersh presented anforcefui sfafemenl abouf

The changes in affifude on medical uses of cannabis in Canada.
in a discussion, he suggasfed l wrlfe To request copies of the
“Brief on Non-Medical Use of Drugs“ and The CMA Review and

Posilion papers, if These are available.
Many

fhanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF:kp

�</text>
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                    <text>May

Mr. E. H. Belter
The Addtction Center
2000 Domanik Drive

Racine. Wisconsin,
Dear Mr.
1n

14, 1970

53404

Belter:

Enclosed are copies of our recent reports on cyclazoc1ne
the treatment of opiate dependence. I trust these are

helpful.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

MF:hr

Encl.

,

.

Ham-1v

"JV—7r.

«,r'VV"

To

�</text>
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                    <text>May

Elsevlar Publishlng
P. O. Box

le

l4, I970

Company

Amsfardam, The Nefherlands
Genflemen:
The Aprll l970 lssue of EEG. clln. Neurophyslo|., Vol. 28,
No. 4, was received damaged beyond use.

"gamma"

If at all posslble

-

we

would appreclafe a replacemenf copy.

4pm.,

Slnceraly yours,

17.

.

”my-ﬂy

Max
my

v-v

.w-«u-nqn'

1'!’

Ayn-VI".

‘I'v'

-—-v

v

.mrvwn

W7:""‘(

11'

“war.

5:

run—nan”

1-H.

Y:-

NWMV’MA’VW

011””:me

:vv

wt».

.

'

.—

Flnk,

M.D.

Professor of Psychlalry

ryw—rrv

MF:kp

�</text>
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                    <text>May

:4, l970

Mr. Gradwell

Confracf Managemenfs Branch
Naflonal lnsflfufe of Mental Heellh

540l Wes? Bard Avenue
Chevy Chase, Maryland
Dear Mr. Gradwell:

In response to your request To Dr. A. M. Freedman regardlng
confracl proposal for The sfudy of cannabls ln Alhens, we are
pleased To answer The two speclflc quesflons —! the role of The

The

lnfernaflonal Assoclaflon and a budge? breakdown.
Slncerely yours,

Flnk, M.D.
Execuflve Dlrecfor

Max

MF:kp

�</text>
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                    <text>nunsawv Wm—“

w—w w

'm.‘-1'1‘

,

-

,

May

:

}

‘

l

i

E

.W

,

“‘\.n.'~.

16, 1970

Mr. Max Singer
Hudson Institute

Croton~on~Fudson, N.Y.

Dear Max,

E

k

E

E

‘

r

l,

I have read the "First Draft of Final Report”, dated

interest, enthusiasm and some eventual disappointment.
Interest, because the report is well-written and some expressions(such
as the need for better enforcement against heroin) are clearly stated.
Enthusiasm, because I know the problem is urgent and any thoughtful

Hay

1970 with

approach should be listened to with care. Disappointment, because I
find the medical aspects treated tritely, even diffidently, and with
an immaturity that casts doubt on the value of the effort. Perhaps my
original doubts are re-enforced by this report. Let me give you a few
examples.
"Moreover, physical damage from even

protracted use of heroin

is rarely serious or irreversible.” (pg 16,par. 1); and, "Current addiction
. . . . is a dﬁseaee one can treat, and in most cases is not terribly
serious even if untreated." (pg 19, par. 2). What fatuous comments !
Death is irreversible, and death is an ever~present aspect of opiate
dependence. So is liver dysfunction and heart disease and post~traumatic
}

g

‘

brain disease. Your views of opiate dependence are the views of the
upper classes who rarely saw the dangers of syphilis or tuberculosis,
diseases of 'those other people', and therefore could say that they
were unimportant—~ until it affected their children. Heroin addiction
is a serious, fatal disease, especially among the young.

seems likely that many or most of those who take up heroin
are weal or immature personalities, perhaps psychologically dependent
types. It also seems likely that the addiction experience strongly

"It

reinforces the tendency tpvard immaturity, weakening the character of
those who might have been stronger when they began." (pg 19, par 1).
There is no evidence for these views, and they are eqyllly fatuous.
How

does

it

help to see the

ill

as "psychologically weak" except to

superiority. I suppose it makes you feel better, for after
not
addicted, therefore you must be 'strong' or have a
are
you
all,
'mature personality'. Come off it, Mr. Jack Armstrong, All—American
assert your

own

Nixon hero.

There is more. I am disappointed that we know so much that
research is not needed. I am delighted that there is little danger
of methadone spillage, especially if the delivery system is computerized.

more

-ps

�WI" We."

.

351w

-

mm,-

W

.

){ax

,

Singer OOOIOOIOOC-l-QOODOI...P8882

w

1W wmrmww:WH-+r

mv~w¢rmau~z("4" ‘W“&lt;:Vm"rm

COCOOOCUODOOCOOIOUBIay16’

It is valuable to

know that a methadone delivery system can be
and
indeed could eventually replace off~track
self—supporting,
as a source of state revenues.

"Wm—W

Remind me

1970

betting

There is some hppe in the future, I am glad to see.
to have faith in the democratic process, if does work.

"WWW.

v...

I

thanks for sharing this preliminary report, and
sure you will appreciate the candor.
My

WW...

am

..

My

Wmvvaum

best regards.

_-

--

Sincerely yours,

E

Max

Fink, M.D.

Professor of Psychiatry

[

mf/

P.S.

Truitt position paper on legalization of marijuana is
equally trite and superficial. The issue is not the medical
data on marijuana, where I agree we need more information, and we
are participating in obtaining the necessary data. The present crisis
is the disparity between the severity of the legal penalties for
marijuana use and possession and the complete lack of evidence of
any harm from occasional use (or the harsh comparison with alcohol
use and its prominent medical complications). The political issue
is in a relaxation of legal penalties for marijuana use and the
clear separation of its relative safety with the severe harm of the
The

opiates.

"1'

~.

w«unm.~n~vw~

many-r

�</text>
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«nu-mm"

-.v--

May

_&lt;-‘-.—.

Mr. E. H. Belter
The Addiction Center
2000 Domanik Drive

Racine. Wisconsin,
Dear Mr.

14. l970

53404

Belter:

Enclosed are copies of our recent reports on cyclazocine
in the treatment of opiate dependence. I trust these are

helpful.

Sincerely yours,

Max

Fink,

M.D.

Professor of Psychiatry

Mthr
Encl.

�</text>
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                    <text>J

v

r

,

‘

'rvgle7grA"IWT~7¢‘—n"2«vwf'

‘3?
.
:vhw'w‘r

v—w

May

Dr. Joyce
1315

W.

Shall,

16, 1970

M.D.

Tenth Street

Indianapolis, Indiana

46207

Dear Joyce,

and

I

It

was nice spending some time together in son
much
enjoyed your presentation at the SBP.
very

Francisco,

I am writing to ask you send me a copy of the letters
to)
Joe Bird of'Sterling Winthrop regarding cyclazocine.
from.(and
am
distressed
that they are discouraging testing of’this interesting
I
compound. I don't think I can do anything directly, but I do talk to
JOe Bird occasionally and I may be able to have him review his decision,
if I know the basis he gives.
at 58?.

Many

thanks, and

my

congratulations to Iver on his election
—

Sincerely yours,
Max

Fink,

M.D.

Professor of.Psychiatry

mf/

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                    <text>"w—

...m W's: ‘ ,. "upg-. —~mzn~wmwu¢ror v-ry'r-m-h—rmmnmwm"

May

18, 1970

Dr. Stephen Bernstein
ECDEU Program, N.I.M.H.
5454 Wisconsin Avenue
Chevy Chase, Maryland

Dear Dr. Bernstein,

In preparation for the ECDEU meeting, I have read the
ECDE! studies finished and reported June 1969 to May,
of
the
report
1970. One one of our studies, that of doxepincchlordiazeponide is

listed.
w—

at least

period:
~vv-1Wmmau—m-ww

3

In discussing

this with

additional reports,

Dr. Simeon, he assures me

Form 22, were

that

submitted during this

Thiothixene in anxiety/depression

AHR~1900

in schizophrenia

Ketipremine-imipramine in depression.

Copies of those

to vou.

reports are enclosed,

if

the originals failed to get

rm"

In my recent telephone conversation, I indicated that I
intended to request a continuation of the program, MH—13358, "EEG and
Human Psychopharmacology" in two parts-— one focussed on EEG and another
on ECDEU in juveniles. The ECDEU application, "Psychopharmacology of
Juvenile Behavior Disorders" is now at our Research Committee and
should be in Washington by June 1.

not meet the June

1

The EEG program

application will

deadline, but will be submitted soon thereafter.

I look forward to seeing you in Boston.
Sincerely yours,
Max

Fink,

M-D.

Professor of Psychiatry

mf/

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                    <text>May

21, 1970

Dr. Jerome Levine
Chief, Psychopharmacology Research Branch
National Institute of Mental Health
Chevy Chase , Maryland

Ref:

101
(MI-i

13353-04
13172-01)

Dear Dr. Levine:

writing to request a re—allocation of the funds
to allow the purchase of the IBM 1800
now
on
a rental basis at this center. This request
system,
requires no additional funds from NIMH end will make
this facility available for continued EEG analyses in

of

I

MH

am

13358-04

psychopharmacology at the annual cost of maintenance.

Specifically, we request the transfer of $71,000 from
the category ”Other” to ”Equipment,” thus reducing "Other”
to $10,000 and increasing "Equipment" to $77,500.
This total purchase price of our system, based
credits for rental is $136,945.

on

the

additional funds are available from NH 18172,
allocated fer equipment to process
the studies of the neurophysiology of cannabis. Purchase of
the 1800 will permit the analyses of the cannabis data
for a $3000 annual maintenance charge.
The

where $48,000 has been

�-

2

-

balance of $12,000 is available in funds of the
Department of Psychiatry and their allocation to this
project are approved by the Chairman, Dr. Alfred M. Freedman.
The

This proposal will make the equipment available to
these study processes beyond the period of MH-l3358. In
the event that these programs are discontinued the equipment

will

be

available to

NIMH

for other scientific applications.

discussed with you, we have carefully assessed
other instruments, notably the PUP-12 and PUP-15 which are
being recommended in similar studies; and while the initial
outlay is slightly less than the IBM 1800, the expense of
re-programming and the interruption in ongoing programs
make the approach to continued work less attractive.
As I

present rental cost is $4330/month. We are
predicating this request on an expeditious approval of
the transfer of funds, effective June 1, 1970 or July 1,
at the latest.
Our

Many

1970

thanks for your considerationaand patiente.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

cc: Dr. Robert Petersen

Chief, Ctr. for Studies
Narcotic &amp; Drug Abuse

ARPROVED:

Alfred M. Freedman, M.D.
Professor &amp; Chairman
mf/

Lorraine Lasker

Direcoor, Research Administration

�</text>
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..

v...“ or... .9.» awnwwu

’

&lt;anr-nnm

May

hiss Janet

25, 1970

Swanson, R.N.

Division of Nurse Education
New York University
New York 10093

.

Re; Daveeda 8. Ross

L

.

Dear Miss Swanson,

I

am

pleased to submit this

for additional nursing training at

New

letter recommending ﬂies Kass
York University.

Miss Ross joined my staff early in 1969 and undertook
special training program in electroencephalography. She soon became
experienced in this technique and exhibited sufficient independence
and interest to asSume responsibility for studies in normal human
volunteers, In these studies, normal subjects are given novel
psychoactive drugs and the nurse (technician) and an assistant record
and evaluate the behavioral and physiological effects of the drugs.'
In these studies she has acted very much on her own and has yielded
interesting and reliable data.
a

'

She has also assumed responsibility for a drug evaluation
in anxious psychotic patients, completing the usual evaluation forms
and maintaining records, interviewing patients and summarizing the data.
In both these activities she has shown a sensitivity to small behavioral
changes and maintained good relations with the subjects, patients and the

staff.

Daveeda is a cooperative, pleasant, enthusiastic and bright
nurse. She has made important contributions to my programs this year,
and I would be reluctant to.lose her participation. I recommend her
highly for additional training, in the anticipation that I will be
able to enlist her assistance in my programs in the future.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
mf/

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                    <text>“rip—w»

n...

--

,

I‘KIVYVHVF‘4‘WJ“.

.

«v- -.

vrrwv,» q—w‘, Awfw\«

("f-S. ti”‘;.mm'-Ir_-u—xmw'ﬁ'.
"Wz'rs; v..."

May

25, 1970

Dear Dr. Ladewig,
and

it is

final details of the CINP symposia are now completed
understanding that you will present a report, Amphetamine

The
my

and Hallucinogen Dependence in Europe, as a joint presentation with
Dr. Battegay.

I am enclosing the application forms for registration
at the meeting as well as the formal acceptance of your report for
the Program Committee.

Please note that the Committee has requested a written
for
paper
publication be submitted at the time of the presentation.
I would like to accommodate the Committee and am asking each of the
participants to cooperate.
I lookeforward to your presentation and to meeting
in
Prague.
you
My

best regards,

and

my

thanks for your cooperation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Chm,

mf/

Session 4,

CINP

�</text>
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                    <text>'WI-"HW-‘u-

-

VII-FKW—v—wzmi-‘ﬁ1) we

~

.

.

.

,

,

May

.

“mummervww

26, 1970

Mr. Jonathan Cowan
34

Humboldt Ave.

Providence, 8.1.
Dear Mr. Cowan,

Your letter of Key 23, 1970 was received and I have
discussed its contents with the Chairman of the Department. We are
pleased to have your interest in the treatment of opiate dependence
with naloxone. It has been difficult to obtain supplies and the
studies are not ongoing at this time, due largely to the lack of

supplies.

error. The general
part of your letter contains anmembrane
and using
chemicals
in
a
silastic
embedding
approach of
research
technique
chemicals
a
of
slow
is
the
delivery
such devices for
that
the
occasioned
by
Our
was
reports
wide
interest
of
applicability.
deliv—
such
a
New
develop
York
was
to
Council
attempting
of
the Population
One

their
ery system for birth control agents. The similarity between and
to
techniques
their
to
and
led
own
us
investigate
our
problems
own.
use their consultants as our

“nu-"w"

Good luck

in your studies.
Sincerely yours,

;V;€Y-F”—-rV-V4'-'

.
air

m-wa—

Max

.
.7

rm

'yvrm.

GT.

m

1'~m

mnwrww

W

”a.

mm

.

«Us:

_.-y—.w.wm

Fink, M.D.

Professor of Psychiatry

yew-amp“:

mf/

�</text>
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                    <text>Humvr'w-x-vvauvn—

_,

"wrwwrw

,.

,..

WV”

n

n

a“. W.w.r:,~.q¢;.~“

nulw

«

«canvas:

mwﬁw-mwvn“—0..“ W... «ems-1m“

,u~.vm.:».‘.;,r-.ym;

-

«MW

May

Dr.

mvru "a.

. wuv..~

y—wwv-

«y".-

.0"?

-u,w.,»n-,,..:,~u‘ mfg-,m-ww-rww

26, 1970

Philip Bradley

The Medical School

Birmingham, England
Dear

Philip,

Dr. John

The only nominations for Symposium 4 support are
Griffith, $400 and Dr. Ian Oswald,_$200. The other

participants have not asked

and I have not

offered.

If additional funds are available, I would appreciate
the opportunity to meet with the panellists and hold a pre-meeting
Such is best done about a meal and I may,
ask your indulgence in Prague.

session.

tight,

if

funds seem

Ivy-:1"

MW

"WA

the

I look forward to seeing

Duke symposium.

w—

My

m-

you in Prague,

if

not earlier at

best regards.

..

Sincerely yours,

“arm—l'nxmvr.-.'n

m:

‘ww—;

Nun—um

»

r

rnr

Mm;-

any;

.—...,

awn-aw»-

-w

~&lt;~w¢mz~w~w~a

r—s-xa-

vr-

Max

Dr. John

Griffith,

M.D.

Department of Psychiatry
Vanderbilt University
Nashville, Tennessee

Fink,

MUD

Dr. Ian Oswald

Department of Psychiatry
Royal Edinburgh Hospital
Edinburgh, EH10 5 HF, Scotland

._ .m

‘rw

w,

�</text>
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                    <text>Nay 26, 1970

Dr. Fini Schulsinger

medical Director

Konmunhospitalitet

Copenhagen, Denmark

Dear

Fini,

It

we have written, but I
friend, Dr. William Karliner,
summer is is interested in visiting
some of the facilities . Dr. Karliner is an expert in convulsive
therapy and has an extensive clinical practice with chronic

has been some years since

writing at the request of
who is visiting Denmark this
am

a close

schizophrenics and the acute depressive psychoses. Would it he
possible for him to visit your facility and meet with anpropriate
members of your staff ? He plans to be in Copenhagen about August
(Wm. Karliner,
1749 Grand Concourse, Bronx, ﬁuw York 10453)

7 ?

I keep hearing good things about your program~ in part
from Jan Volavka who hears from Mednick, and in part from Seymour Kety,

has presented the findings of your studies widely. Last I heard
Sarnoff was planning another decade of study plus an adventure ior the
Who in Hauritius. I hope these go well.

who

studies continue, focussed on EEG and drugs-— now
the narcotics, cannabis and their antagonists, as well as the special
problems of ECT. We have become the local experts on the narcotic
antagonists, particularly cyclazocine and naloxone, and have even been
asked to plan some studies of cannabis in Greece. (These are unrelated
studies, but there is a great overlap in the funding of the narcotics
and cannabis). Volavka seems to be enjoying his work although he is
Our own

concerned about

life in
is

New

York.

and in college and away from home. The
girls, 12 and lé are doing well in school . Martha is teaching first
grade and seems to enjoy it very much.
ﬂy son

now 19

about calling us the next time you are in New York ?
My staff would love to hear about your studies first hand, and I will
be pleased to arrange a seminar. Please call.
How

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>May

26, 1970

Dear Oldrich,
Symposium

I believe I have carried out each of your wishes for the
4, and I am delighted with your cooperation in the matter of

the co-symposium.
As

I understand

and Ladwig, sending them the
have already registered.

it,

I have written to Drs. Griffith, Friedhoff,
assume the others

registration materials. I

I have written to Dr. Bradley about the support, and as I
have not heard from Dr. Davis, assume he needs no
support. I will check
again, but if you do not hear from me in 2 weeks, assume he needs none.

I have reminded each of the participants that their reports
are due for publication, at the time of the meeting.
I plan to have a meeting with the participants before the
will ask you, in Prague for a suitable restaurant or
meeting place, where we can discuss and plan the meeting and also
become better acquainted. I would be delighted
if you will find the
time to join us. (The evening of August 11 or luncheon August 12 ? )
symposium, and

symposium

(I have

assumed

Keep up

the

that

after your letter.)

Dr. Ladewig

good work.

will present in this

I look forward to seeing you in Prague.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>,:.v.—.WWW- PW.

'V'Ff'nwu-n m»-5 qua-um

av

_

.

.

r
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. vmr—w—W
hwrﬂvt'wi!WIW~4"mw-WJPw-w-rgnwywwuw.m,k.,m,-v.,n;....~

pm

.

,

.

May

”W.

.

.

.,

,

"u

T.

26, 1970

Mr. Jonathan Coven
BA

Humboldt Ave.

Providence, R.I.
mgr.—

Dear Mr. Coven,
"IV-4.54““

..

‘-n‘n—

wmww—w—w

manure“

Your

letter

23, 1970 was received and I have
with the Chairman of the Department. We are

of

May

discussed its\contents
pleased to have your interest in the treatment of opiate dependence
with naloxone. It has been difficult to obtain supplies and the
studies are not ongoing at this time, due largely to the lack of

supplies.

part of your letter contains

general
using
approach of embedding chemicals in a silastic
research
chemicals
technique
of
a
is
such devices for the slow delivery
the
occasioned
by
reports that
of wide applicability. Our interest was
New
York
was attempting to develop such a deliv—
the Population Council of
ery system for birth control agents. The similarity between their
problems and our own led us to investigate their techniques and to
use their consultants as our own.
One

Good luck

error. The
membrane and

an

in your studies.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

.whym

u

were——

�</text>
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                    <text>P;

~ -

~

~

--

m-

.

-—u

«were

w».

7-

—-.

"-w-zw-van-WJ;

xrv'rm"r&gt;mv -.-

~

Wﬂ'nmi'ﬁ'v um-nw..¢~mv.

r3!

wmmml’i-VW'9Cwmyuwirm'w-qu—mn.

May

i.

.

»V.-.
--

.
sung-u--

~

. A..

rV

m... W,

wwa .

,
,.—

Y.N.—p.m-v.m—- wran— m.

25, 1970

W,

Dear Arnie,

’I‘"W:'Y-N.1"w-fr;y-n-

;

?

*

Enclosed is the formal acceptance of your report
Amphetamine Metabolism in amphetamine psychosis for the CINP in
Prague, as well as the registration materials. If you have not filed
these before, it may be helpful to do so promptly, since a visa
is required for admission to Czechoslovakia, and the room situation

is not like

.

g

Miami Beach.

Please note that the Program Committee wishes to publish
the reports and ask that 2 copies be submitted at the time of the

presentation.

Many

é

thanks for your

participation,

and

best regards.

my

Sincerely yours,
Max Fink, M.D.
Chm, Symposium

mf/

4,

CINP

ﬁn...

�</text>
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May

29, 1970

Ellen Grass
Grass Inetrwnent Co/
Quincy, Mass.

Dear Ellen,

electroencephalograph will have been
I trust the smallthank
want
to
you for the loan of the machine
I
when I found my work overwhelming.

delivered safely.

at a

time

In checking, I find that I have used the various
the
supply package, and I wish to ask you to send me
parts of
the
use of the machine and these parts, shipping, etc.
a bill for
Again,

my

thanks .

Sincerely yours,

E

i

Max

Fink,

M.D.

Profesaor of Psychiatry

Mf/

.

�</text>
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-.

unrw-

man-

May

Dr.

29, 1970

J. Alan Burdick

Univereity of’Manitoba Faculty of‘Medicine
Winnepeg 3, Manitoba

Dear Dr. Burdick,

I have

considered your suggestion
of a chapter in your volume, "Quantitative EEG Analysis", and were
left with a few questions, the answers to which would assist us in
defining our contribution.
my

associates and

1. The chapter

titles already

2. Publieher and

approved and

their authors;

publication date;

3. The intended audience and the secondary audiencegand
4. the

contract specifications for contributors.

It would also be helpful for us to know from which point of
view the volume is being written, i.e., historical, technical (primarily
methode ?), applications, or ? ? ?
a volume.

I have

I

for your invitation. There is a need for such
recall that Paul Naitoh had planned such an effort and
Thank you

outcome. we believe such a venture to be
would
be pleased to assist in its development.
and

not heard of the

interesting,

Sincerely yours,
.4sz Pink, I403.

Professor of’Peychiatry

mﬁ/

�</text>
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                    <text>~s

m,

Ayn—cram.

nu- . 4-,.

awn—aw

“1",!“m‘x ‘1'11'pPI1: rum“, wry-:15:tern-r.Mw—nﬁr».vrw'rwwuwmiw ' arnxs-vwwwmvmvv-w vr-vr-wnwvcm run-v

-

.

w.

.7..-

,Yr-I-v"

W"

at“

May

Dear

26, 1970

Everett,

Thank you for your invitation to participate in the
Duke symposium. As I mentioned on the phone, I am running a meeting
on Narcotic Antagonists in Opiate Dependence on June 4 and
I have
enough energy
will fly down on Friday, since I am particularly

if

left,

interested in the Saturday presentation.

Your paper submitted to the CINP is accepted in the
co-symposium on amphetamines, and will be presented on Thursday,
August 13 in the afternoon, I will be chairman of that session.
The main symposium will be held on Wednesday afternoon,
and a copy of that program is enclosed. While the Program Committee
viewed the sessions as separate, I convinced them to allow me to
one symposium~- which they agreed.
join the two and to call

it

For your program, I note that you have omitted the
neurophysiology of amphetamines as seen in man-- a small but important
distinction. If you plan to publish your proceedings you may wish to
ask either C. Shagass, T. Itil, Ian Oswald or myself to contribute
a small report or overview of the recent EEG [clinical data. John
Kramer has some EEG samples and data, and could augment his report

if

you remind him.

you.

Have a good

session,

and

I

hope

that I

may

be able to

My

best regards.
Sincerely yours,

W'm-‘wlv-—

~

.77“

r-

WWI—wwu-gr

'v
-

Vvy’yw'q—ﬁm'v—W

i.
.w

.m

,un-”

—:--—I

,

Ch “.195
Efﬂ‘kw'f‘.“a

"rnw-mt-F

'vm~

_

Fink, M.D.
Professor of Psychiatry

Max

join

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                    <text>April

2,

1970

Dr. William Tabor
Robins Co.

A. H.

1407 Cummings

Richmond,

Virginia

Bill,

Boar

Enclosed is our final report on AHR-IQOO. I believe it is
suitable for publication in Currant Thortpoutic Research and will
Such publication would
submit it, if you think it is advisable.
AME-1900
be
of
studios
useful
were planned.
furthcr
only
if
and

I have received the data analyses from tho Biometric Laboratories
separately I am sending a copy of their report and a duplicate

data deck.
We

and I

are proceeding with our fonfluraming roaction time analyses
will be in touch with you shortly.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MP

:kp

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                    <text>April

2,

1970

Dr. William Tabor
Robins Co.

A. H.

1407 Cummings

Richmond,

Virginia

Bill,

Boar

Enclosed is our final report on AHR-IQOO. I believe it is
suitable for publication in Currant Thortpoutic Research and will
Such publication would
submit it, if you think it is advisable.
AME-1900
be
of
studios
useful
were planned.
furthcr
only
if
and

I have received the data analyses from tho Biometric Laboratories
separately I am sending a copy of their report and a duplicate

data deck.
We

and I

are proceeding with our fonfluraming roaction time analyses
will be in touch with you shortly.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MP

:kp

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                    <text>Mic—WW

r—w-zr-w—va—w- u—v .

.

wwwxw‘:‘l~.

m o—r‘w—

,

,

-

~

,

,

'I-u' mn’nvww'. "aw-v

0

April 3,

W mow
-

7-.“

\

1970

Dr. Ali Keskiner

”issouri Institute of Psychietry
5400 Arsenal Street
St. Louis, Missouri 63139

Bear Ali,

It was a
comments are
is

me

pleasure to read your application. and
hand-written in the text.

many

of

ﬂy

In general, the ideas are presented well and the argument

to

it

I found
repetitious
make some suggestions.

good.

in

some

parts.

which

inspired

is excellent, and the methods are clear. There are
The greatest
~ some are indicated in the margins.
weaknesses
some
weakness (and one that effected MB 11381) is in the initial selection
The aim

and testing of patients. It is not clear how the experimental
group will be selected, nor whether they will be drug free (did
I miss something?) and for how long.

I would also question your estimate of statistical and computer
costs. These are always much higher then estimated, and your
estimates are very low.
I wonder why you

omitted a

summary

you related it to am. this summary
drugs and special remedial training.

As

case summaries as

MS?

of the Stuart experience.

showed the interaction of
Or is she included in the

There are many subbestions for special therapies for schizophrenia.
But none are given in isolation, and combined therapies are the rule.
One of the principal assets of TRP was the control of drug therapy ~
and while you suggest

it

in the

test, it is not explicit

enough.

�I __,.

w.

wan-mm”

3"

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my.

y

‘.

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or. Xesklnor

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April 3.

A

1970

All patients should receive standard medication, not experimental,
I am imrressed by Philip
plus romedial (or plus control therapy). ethasizing
the value of
Kay's hook on therapy of schizorhrenia, could be placed in the
combined therapy. Perhaps your project
same framework.

your
between this program
Finally, is there a connection
out.
be
should
spelled
Special aftercare? If so, it
of
The project is interesting, novel and a logical follow-up
command
attention.
some
should
the TRP. Within this framework, it
and

My

best wishes.
Sincerely yours,
wax Fink, W.ﬁ.

Professor of Psychiatry

Mszp

�</text>
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                    <text>April 7,

1970

Dr. Joseph Zubin

722 West 168th Street
York, New York 10032

New

Dear Joe,

Enclosed

for the

My

1970

is a typescript,

proceedings of the

"CNS
APPA

Effects of Convulsive Therapy",
on “Disorders of Mood”.

thanks for your invitation and the opportunity to take

part in this interesting

symposium.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc .

�</text>
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                    <text>war-Fr.

April 9,

w...

~..

'R.'vm'r-rv

Dr. Milton H.

«”qu

.u—s

u

~

Chief,

Joffe

Drug Sciences

‘1‘

WWWvu-su—n-v mmwm-wmw. W"

w—w—rz—r-«w-n—v-v

1970

Division

United States Department of Justice

Bureau of Narcotics and Dangerous Drugs

Washington, D.C. 20537
w“.

e

Dear Dr.

Jeffe:

There are two programs relating to substance abuse in the
Division of Biological Psychiatry of this Department.

study program "Quantitative EEG Studies in Psychopharmacology”,
partly supported by MH-lSSSB is dedicated to determining the relation
of changes in brain fonction in psychiatric patients and volunteers
in response to established and experimental psychoactive drugs.
A summary of this work which has been continuous since 1954 was
published in 1969 and reprints reflecting this experience are
enclosed.
The

Our second program is dedicated to substance abuse, particularly
opiates and alcohol. This program is largely supported by a contract
with the New York State Narcotic Addiction Control Commission. The
focus has been on determining the clinical efficacy of various psychoactive drugs in altering the drug dependent state. We have published
our clinical results with methadone, cyclazocine, naloxone and tybanate.
Because of our interest in neurophysiology, we have applied the
techniques to our abuse studies and have reported the EEG changes
with methadone, cyclasocine, and naloxone.
Copies of these reports
and some of the preprints are enclosed.
same

.wwwg...‘

W'-‘l

-n—

;.-,m-rwmrv.

\
‘3

;
i
F

g
k
P

,

This program of research in substance abuse is new extended to
alleged substances of abuse, notably marijuana, hashish and THC. While
this work is unsupported, we are optimistic that the National Institute
of Mental Health may look upon this work with favor.

mwv u".-

�Dr.

Joffe

April 9,

~2~

1970

One of the special issues which has interested us has been
the pharmacology of heroin and methadone. We have utilized
intravenous heroin as a “challenge” to the cross tolerance of
methadone and the antagonism of cyclazocine and naloxone.

put this program in its proper perspective, you should
that the principal investigator of some aspects of this
nrogram is the Chairman of this Department, Alfred M. Freedman, H.D.
Me is also co~director of the Center for Studies of Substance Abuse,
another division of this Department, under the direction of
know

To

Professor Richard Brotman, Ph.D.
I

trust this information is helpful.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mﬁ:kp

�</text>
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7

v

,

,

'mwmmm‘mw

,

April 8,

1970

Dr. James A. Shield, Jr.
Branch

Clinical Resenrch

National Institutes of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Jim,
As

MH~15561~02

RE:

I discussed with you today, we have

great deal of data in our

out the proper

ECT

study.

statistical tests

of the college‘s computer center.

It is

we

collected

a

In order to carry
have utilized the facilities

understanding that these charges may properly
by the transfer of funds from Personnel
or Supplies to the category ”Other“.
my

be paid from

this grant

If this in in error, please notify

me.

Sincerely yours.
Fink, M.D.
Executive Director

Max

Mszp

cm" V,

�</text>
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                    <text>4

“wwuy‘.«-mewovw-;www- mu.

.-

‘ q:

'

T__

i7

April 8,

,

.

1

m

1970

Dr. Arthur M. Sackler
William Douglas McAdams, Inc.
130 East 59th

New

York,

New

Street

York 10022

Dear Dr. Sackler:
Thank you for your interesting papers, presented before
the Second International Congress. The emphasis on alcohol
as a toxic substance is, of course, consistent with our own
experience.
We have tried for a number of
years to support the techniques
of antagonists in the treatment of opiate dependence and found
that political cooperation was very difficult to achieve. However,
the work of this department stands as the single most active unit
in the United States dedicated to studies of antagonists. like
cyclazocine and naloxone in opiate dependence. It is an interesting
story which has not been well told.

Again,

my

thanks for your comments.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
MP

:kp

-

va"

,

;

;

“nww

�</text>
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                    <text>April 9,

1970

Dr. W. Keup, President
Eastern Psychiatric Research Association, Inc.

681 Clarkson Avenue
Brooklyn, New York 11203

Dear Dr. Keup:

In today's mail we have distributed copies of the EPRA
program as you requested. I plan to attend the meeting and
look forward to seeing you there.

Sincerely yours,
Max

Fink, M.D.

Secretary

�</text>
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                    <text>TO:

Alfred

FROM:

Max

SUBJECT:

Fellowship Status, Dr. Jan v. Volavka

M.

Freedman, M.D.

DATE:

April 9,

1970

Fink, u.n.

Dr. Volavke requires two years training credit to achieve
entrance to the New York State licensing examination. One year
may be in psydhiatry, and the second in another clinical discipline,
3.5;, medicine, neurology or pediatrics.

For

this year he requests

an

accredited program in psychiatry.

Following our discussions, I suggest the following curriculum
which, if satisfactorily completed, should meet our ”training”

requirements.
1.

2.

3.

Course work - any of the following:
(a)

Introduction to Psychoanalytic Techniques.

(b)

Principles

(c)

Continuous Case Conf. in Group Psychotherapy.

Clinical Supervision

ﬁr. Wolherg

and Techniques of Group Supervision.

~

Dr.

c. welter-

Dr. E. Fried

Either of the following:

(a)

Individual psychotherapy,

(b)

Group psychotherapy

by Dr. Negler (and
Dr. Sadock (and

~ 1

2

cases, supervised

staff).

group, supervised by

staff).

Clinical Service.

Case management and responsibility for patients in one
of the following projects of the Division of Biological Psychiatry.

(a)

Comparison of

(b)

Anti-narcotic activity of

(c)

Child Psychopharmacology program

anti-depressants in
PCPA

subjects - Pink, Zaks.

PHP

- Finger. Simeon

in opiate dependent
~

Simeon, LaVietes

If these suggestions meet with your approval, I will try to negotiate
the details with the supervisors and clinics involved. I prOpose Dr. Volavka
be given credit for an academic year, 1970.
MP

:kp

�</text>
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                    <text>:~wW"m-cm‘n

&gt;--mlwwﬂ9‘wr'n‘va- ad‘Qw'rw.

vow-w:

‘u‘a—"ﬂ‘mw"

WW ,vw'ww :u- at

April 9, 1970
Mr. ﬁerman S. Weisman
Eeffman La Roche

Nutley,

A.

y-v

ﬂew

Jersey 07110

Dear Mr. Heisman,

.mp-

«pm—um”;

;
-

—

'v

Despite the outcome, I wish to thank you for the
your
efforts you have made in presenting our point of view tothat
the
proposition
to
accept
associates. It is difficult
there is a clear relation between brain function and behavior.
I hope that the data we are now presenting serves to change the
general point of view , that the EEG is a useless instrument,
and that more applications will be made, particularly in
psychopharmacology.

that we have already begun our
find a clear profile at 25 mg
to
failed
initial
chlordiszepoxide, but the changes at 50 mg are consistent.
You should know

survey, and

Again,

my

you

will

such a study will always be
come and visit at your

thanks for your kind presentation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

,

wan—«r

r

:-

participation in

I trust that
earliest opportunity.

welcome, and

,,

m;':—N;

Your

mfl

�</text>
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                    <text>April

10 , 1970

Dr. Jonathan 0. Cole

Boston State H05pital
Boston, Massachusetts 02129
Dear Jon,

After your telephone call, I asked Dr. Volnvka to check
on the question of hyperbnric oxygen and EEG, and the following
are his notes:

literature deals basically with two aspects of the
problem: oxygen convulsions and the therapeutic use of hyperbaric oxygen. The most recent work on convulsions (Morel,
Kerom and Levy, 1969), apart from asserting that the seizures
have a random origin (at least in the rabbit), also provides a
useful survey of the older literature.
The

Therapeutic hyperbaric oxygen effects on

were reported
by Levy-Alcover gt 31;, (1965), Marinchescu and Poilici (1966),
and Goulon et alt (1968). In patients with cerebrovascular
diseases, hyﬁergaric oxygen caused widely heterogeneous EEG
changes (either some flattening, or an amplitude increase, or
sharp elements) and this was interpreted as indicating that
oxygen might have resulted in cerebral vasoconstriction in some
cases. This would have accentuated any pro-existing hypoxia.
EEG

In London,iin 1966, a heterogeneous group of neurological
patients convalescing from brain anoxia or injury were introduced
in a hyperbaric chamber. I reviewed the records of 5 patients
and in this inadequate couple, saw changes reminiscent of the
initial stages of sleep ~ a lower of amplitude and slowing of
dominant frequency .

�Dr. Cole

The

April 10,

~2—

1970

references are:

Harel, D., Kerem, D. and Levy, S. The influence of
high oxygen pressure on the electrical activity of the brain.
Electroenceph. clin. Neurophysiol., 26: 310—317, 1969.
Dordain,

G.

Goulon, M., Levy-Alcover, M., Nouailhat, F. and
The BBC

clin. NeuroPhysiol.,

in hyperbaric oxygen therapy.
25: 90, 1968.

Electroencephl

Levy-Alcover, M., Goulon, M., Nouailhat, F. and Augustin, P.
of
study
patients undergoing hyperbaric oxygen therapy: first results.
Electroenceph. clin. Neurophysiol., 19: 608, 1965.
EEG

the

Marinchescu, C. and Poilici, I. ﬂyperoxic effects on
background activity in cerebrovascular diseases. Electroenceph.
Neurophysiol., 21: 95, 1966.

EEG

clin.

I

trust this is helpful.
Q

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>dawn-7w

April l0, l970
Commanding Officer
365 General HosplTal
iOO NorTh ForesT Road

Buffalo,
Dear

New

York

Sir:

This leTTer is in supporT of Dr. Zaks’ requesT To be
assigned To ForT HamllTon during The April 25 Through May 9
reserve Training period.
Dr. Zaks is involved in The TesTing of several drugs
in The TreaTmenT of nercoTic eddicTion. These are poTenT
agenTs and iT is imporTanT TheT These paTienTs be closely
moniTored. The assignmenT of Dr. Zaks To a feciliTy in The
New York Area would allow him To deal wiTh any problem siTuaTions
TheT may arise during ThaT Time lnTerval. Because of The complex
problems ThaT may arise during The TesTing of new drugs, iT is
necessary for The DeparTmenT of PsychiaTry To have available
Dr. Zaks experTise in This area.
Or. Zaks' assignmenT in The New York area would be The
soluTlon To a difficulT problem ThaT we would oTherwise encounTer
aT The DeperTmenT of PsychlaTry of The New York Medical College.
Thank you for your serious consideraTion of This maTTer.

Sincerely yours,
Mex

Fink, M.D.

Professor of PsychlaTry
MF:kp

,,

«a

-

.

w.

w'av.(‘rwn

-

-

—

.,.

�</text>
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                    <text>run-“=-“WV“:"F‘F‘I'T

v "-‘wxw «wry-“rpm

,

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as»: 2-1. .aJ;Aa._A.s,~:m--.,

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ctlj'v

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,.

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u’u“/-;—mr~:v-wyw’mm~rumwgmn‘wwvrmvwwmw.

Mar” :0, mm
Br. Wiiiiaa Tabor
A. H. Rabin: Company

,

;

14$? Cummings Reaﬁ

;

Richmond, Virginia

Saar

ﬁiii.

hava camgiaiad fhE data anaiy$as en #ha Misseuri
fanfiuramine raacfion time data. Eariiar ya had raviaved fha
function fime inf¢rmefion and we hava new comaia+ad fha behavicrai
ﬂan and

i

and £EG dafa. Summari¢s are aaciosad, markad “interim ﬂapcrts”
Marah iQ and Aprii 8. The nriginai data analysas are in car

iabarafory.

puzzling compaﬂanf. ﬁubjacfs in groug i haw»
a significanf érug aifec? (thav received pincsbw for *hrsa Igeks
bafora arug) whiie suhjects in group ii hava a weak attact. ya
axamined fhe daia for dasaga by weighf and faund ii++ia variatiaa
in dase ~ (caicuiafmd as pcunds/capsuia, i t 4?. 75 t 8.ﬂ3 and
we mate one

E

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i

ii

i

67. 90 ‘ ﬂ. 2i)

reacfien #ime E55 and behaviorai dafa ara all in fha
sama direcfian and unpaar ennsisfanf wifh the interpretufion thn?
feafiuramina was acting as a saaaiiva drug. Whiia muifivariafe
stafisfics can ba dong; ya ara n9? sufficienfiy comfortabio wifh
fha behaviorai data in baiiava that fha resuits are worfh fha
The

axpansm.

Affar raviauing fhis aaia. weuid

you

pinasa caii ua.

Sinceraiy years,
~

nr-yrv-vmv.

Max
Tamar-

2

Fink, H.9.'

Prefessor 9f Psychiatry

an-vww'w:

ir‘F 2 kg)

cCs

gr. P. Preston

�</text>
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                    <text>April 11,
Pergamon Press

Elmsford,

New

1970

York

Gentlemen:

Kindly enter a continuing subscription to the
Journal of’Esychiatric Research, effective with the Januari,
1970 issue, addressed to:
Fink, M.D.
Department of Psychiatry
New York Medical College
5 East 102 Street
Max

New

I would also ask that the
sent.

York 10029.

1969 volume,

if still available,

be

If I understand the instructions correctly, this
subscription will be at the annual rate of $10., since we are

already subscribing as a Department throgh our library at
Metropolitan Heapital.
and

as

bill

Please make the subscription rehewable until cancelled
us annually.

billed.

The 1969-1970

subscriptions will

be paid as soon

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

mf/

�</text>
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                    <text>April l6, i970
Dr. Burton w. Rocklitf
Regional Medical Director
Geigy Pharmaceuticals
255 North "D" Street
San Bornardino, California 9240i
Door

Burt,

Pardon the delay in answering your lettor, but i wished
to share your paper with Dr. Simeon, my co—worker, before
answering. We both found your report useful and productive,
and hope

that you/will publish it.

used a mean score for each item to
symptoms, before and after treatment.
showed
less change than most symptoms, and
it shows that insomnia
dopressed appearance, more change. This portrayal, however, is
poor and i would agree that if one has a large enough sample,
Anova is a good way to handle ' the data. Your reference to our
work is accurate.

report, we
develop this profile of
in our

refer to the "purely antidepressant
interesting idea, but one that may need more
actions of drugs”.
oxpounding since ”pure" depressions seem very rare in our populations.
in this regard, the assertion that anxiety, tension and fears are
not part of the primary disease process in depression is difficult
On

page l3, paragraph 3, you
An

to accept.

sorry we failed to credit your work - i did think it Wealready
was in the public domain, since l've known it for some yoars.
will give you proper credit in our next study of depressives.
i

am

Meanwhile, come and

visit

us when next you are in

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

New

York.

�</text>
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                    <text>.v;...._~n-..

,

31,“.

A;.A-r~._v,._

my.

April l5, 1970
Dr. P. Kielnolz
Psychialrlsche Universllafsklinlk Basel

Wilhelm~Kleln«Slresse 27
4056 Basel, Swiizerlend

Dear Dr. Kieiholz:
have received various lefTers from fhe CiMP Program
Chairman, Dr. Vinar, and my answer To The lalesl is enclosed.
l

l.

The symposium The? has been submifled

filles lisfed.

conslsfs of fhe

2. The co-symposlum is fo be made up of submiffed "free
communicallons“. My leiier to Dr. Viner suggesfs we could have
all l2 (absfracfs enclosed) bul would prefer l—8, suggesfing
9~l2 #0 be presenfed in The "Free Communicelions“. The decision
is To be leff To Dr. Vinar.
asks That one of us summarize fhe proceedings in
The Plenary session. Since i am presenfing in fhe symposium,
3.

He

would if no? he appropriefe for you lo summarize ihe sessions?
i would be delighled To have you do so.
a

find

The papers of the Symposium and co—symposium may make
issue of a journal, and i would ask if you would consider

4.

This for your journal, Pharmakopsychlefrle? (lncidenlelly, your
leffer of February 9 was no? clear whelher you did indeed wishof
a reporf on anfagonlsfs and meihedone for a subsequenf issue

Pharmakopsychiefrie.)
i

look forward

to our

working Together in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychielry
Mszp

�</text>
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                    <text>April i5, l970
Dr. Oidrlch Vinar

Psychlafric Research lnsfifufo
Prague 8 - Bohnice

Czechoslovakia
Dear Oidrich,

Just received your leffer of April 5.

8 and 9, as
in
communicafions
alphobofic order.
well as The grouping of free
My air ioffer of April i2 leff before i received Those nofes, and
i
now know fhaf you have received The full panel, including Tlfies;
and you know fhaf I have accepfed fhe l2 papers iisfed as the
”co~symposlum”, to be grouped firsi by a human ~ animal confinuum,
and second by confenf. i would suggasl an order of:
I

have

leberg

Sandison

Angrisf

Suchanek ~Frohilch
Eilenwood

Cohn

Lowander

Krwickaja
Knoll
Lyon
Guzok

Zabik
While we could hear i2
(mm

leborg - Krwickaja (ii-8)
in ”Free Communicafions”.

.A~A-,l....,v?h

w

,
.
-

Ia'nvnmvwm

"w

a-uxg-

.~

Wino

'

:r'r.im‘y

mn-

,
"'9

has

r

prefer 8 and suggesf fhaf
in
be included
fhe co-symposium, and #9—l2

reporfs,

i

would

is This feasible?

�Dr. Vinar

April i5, l970

-2—

Dr. Klelholz or I will accepf fhe responsibliify lo summarize
the symposium on Safurday, Augusf l5, in The plenary session.
As To your

You

quesflons

To The

(l)

Of course,
you should

(2)

For The co-chairman on cannabis, would you consider
Dr. Alfred M. Freedman of our College lnslead of
Dr. Keup? Dr. Freedman is planning +0 offend The
Congress, and is +he co-direcfor of a naflonei
Confer for Sludies of Subsfance Abuse.

if

a proposed chairman

is unavailable,

replace wlfh anofher colleague.

are doing a fine Job.

celebralion

Program Commlflee.

in Prague!

Keep

if

up ~

and we will have a

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychialry
MF :

kp

cc: Dr. P. Kielholz

�</text>
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                    <text>April l6, l970
Dr. John A. Scigllano
Confer for Sfudies of Narcofic and Drug Abuse
Mafional lnslifufo of Manfal Healfh
5454 Wisconsin Avenue
Chevy Chase, Maryland ZOGIE
Dear Dr. Sclgliano:

Enclosod are xorox copies of my lelfer of March 23, l970,
The record of nmrijuana used, fhe pregress roporf of March l970,
and a xerox of The Tax Stamp. ln addlflon, a copy of a leffer
fhaT l have jusT wrlffen +0 fhe Dlsfric+ Diracfor of Internal
Revanue requesfing fhelr cerfiflcaflon fhaf The Tax Stamp has
indeed been lssued by fhom and is nol counfarfelf is also

enclossd.

in order To accomplish The prasen? range of

studies before

summer recess lnTerferes wifh our subjects, we would like +0
begin on Monday, April 27, and i would appreciafe your earliesf
affenfion #0 our reques? for lOO Grams of marijuana.

the

Slnceroly yours,
Max

Fink,

M.D.

Professor of Psychlalry
mf:kp

encs. Tax STamp
Progress report 3/l/70
Use of MarlJuana
Letter #0 IRS

�</text>
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                    <text>'-

-ngnrw

uixwmr

u

,..‘v

r myT

."x
‘ \_,

"VI-V

,

,

‘

.

_

.

.

‘1“.

'ApPUI

Mr. Eéward

,

I6,

.A

M

-mﬂ,,.~-_n

ya...

._.

w

an“,

-m‘—mppwyv.

3970

J. Fitzgerald, Jr.

015?rlcf Direcfor of lnfarn&amp;l Ravanua
IZO

Ngw

Church Sfraw?
York, Haw York

Dear Mr. Ft?zgara0d:

Enciosad is a raquast from Dr. John Scigllano for a
cer+lflca+lan fhaf Tax 5?amp 457003 Issued on my behalf Is
proper and no? counterfeit,
tnscfar as we are In the mics? of a program of study

and addtftona! supplies era necassary,

earliasf affanflon fa fhis requasf.
I

wouId be

l

would appreclafe your

grafaful for your ceaparaflon.
Slnceraly years,
Max

Fink, M.D.

Profassor of Psychtafry

Mszp

n; v “pa-w

X‘N‘J":

"-r‘

‘v

.

7...,va

�</text>
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                    <text>.1,

'v’

April i6, |970
Dr. Eugene L. Nowickl

Assoclafo Director of
Clinical lnvosilgafion
Lederle Laboraforles

lll

New

Wes? 50in

York,

New

Sfreef

York

IOOZO

Dear Dr. Nowlckl:
l

and nofe
Based on

have read ins dais on Loxaplne Succlnafs wllh lnferesl,
lhaf you have an exienslve clinical ovaluaflon compleled.

fhls data your proposed sfudy is reasonable.

are focussod on lho principal of evaluating
drugs, and from The profile prodlcflng
clinical applications. We are now engaged in early Phase sfudles.
The enclosed sample profile analysis prolocol of one of our recent sfudiss
exemplifies our approach.
Our sfudy programs
The EEG profile of novel

I

The proposed sfudy is no? wlfhln our

Phase

lnleros? ai lhls flme.

in The even? Tho? you have oihar compounds which may require
I
ovaluallons, we would be pleased To review The animal data.

Thank you for your inforesf, and
opporfunify To work fogsfhsr.

l

lrusf

we

will have an

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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                    <text>inw—wmzru

c

April l7, l970
Dr. Norman

Pills

Chas. Pfizer &amp; Sons
Grofon, Connecticut
Dear Norman,
In response To your requosf, I am encloslng ceples of our
Neurosls" and
report ”Lacfafe Preclpifafed Anxiofy in Anxlely
our Ielfer lo lhe New England lgyrnal of Medicine which has been
published. The Two roporfs by Ferris Pills are enclosed, as well
as The negaflvo paper by Grosz and Farmer.
Our work wiTh

laclafe provided us with

an

lnferosfing

opporlunlfy lo Teal fhis Theory of anxiefy. Wifh fhe awareness
fhal calcium can block lacfafe preclplfafod anxiofy, sludles of
known an+l~anxiefy agonfs such as doaepln would be very
My

besf regards.
Sincerely yours,
Max

Flnk,

M.D.

Professor of Psychlalry

Mszp
GOCS o

lnlerosflng.

�</text>
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r‘w'vnw—Vm‘xw

~

’

».

.

-

«

~

'

,;

’K?"

mpg—

‘

Aprll l7, I970

Ir.

Davld

Box I439

M.

Nathan

Amherst College

Amherst, Massachusefls

Dear Mr. Nafhan:
have presenled your leffer +0 8 number of my associates,
regref +0 say fhaf we have no poslllon lhls summer.
l

and

Your credentials are exemplary, and
anflclpafa Thu? we
wlll be worklng next summer. ln fhe evenf you are ln+eres+ed ln
parflclpaflng in sfudles of drugs in volunfeers, would be
pleased To hear from you.
l

I

Good

luck In yoursfudles.

Sincerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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                    <text>wwv

_

.

mmwuvwww..n-- rumvrxwﬂ a-v-uv:

:‘r-u

awn;- "aw-v

saw v”,

i

”~st

r m.

«w-

l

, ,.

we

Aprli

A

..

2|,

l970

Dr. Charles Shagass

Easiern Pennsylvania Psychlafric lnsiifufe
Abboffsford Road
Philadelphia, Pcnnsylvanla

Henry Avanue
Dear

&amp;

Charlie,
i

would

like

for membership
copy of his curriculum

To propose Dr. Jovan Simeon

Society of Biological Psychiairy.
vifae is enclosed.
in The

A

sincc i965. He has
all
early clinical drug evaluaiion programs
parflcipafed
boih a? fhe Missouri insfiiufe of Psychiairy and in New Yerk.
He has established a program in child psychopharmacoiogy and,
i believe fhal he will continue +0 confribufe To our field.
Dr. Sinmon has been working wifh
in

#he

me

Sincerely yours,
f’iﬁX

F‘ nk,

My

00

Professor of Psychiairy
MF:kp
BBC.

�</text>
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                    <text>:

V."‘»V~'.'qV:"»-W --

»~.v&gt;~&lt;cr~-

April

0r.

Turan

M.

-

2|,

m

.wm

WW""’-

»

'~.l"av'lum~.1.n—:,

.7. .7

wﬂwﬁﬂgxw.’ v.

I970

lfil

Missouri Insfifufa of Psychlafry
5400 Arsenal Sfreef
8?. Louis, Mlssour! 63l39
Dear Turan,

Separately am sanding you fwo boxes which confain
reprlnfs and papers fhaf yau requesfed some Time ago.
I

I

*rusf

seeing you
My

you had a happy

In San

Francisco.

vacaflon and

I

look forward

best regards.
Sincerely yours,
Max

Fink,

MOD.

Professor of Psychlafry

MF:kp

V

A

WW7)!"

to

_-‘,.

7.

“Mp."

-1,

v‘

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2i,

i970

Dr. Leonfi H. Thompson
Program Chief, Mental Health Services
Confra Costa Counfy Medical Services
2500 Alhambra Avenue
Marflnez, California 94553
Dear Dr. Thompson:
0-“.

.,
W

”mm

ynmum

The compuier

EEG

analysis, as

visif

i

Sincerely yours,
I"
A,

.t»

Max

a

navy“.

‘r

Fink, %.D.

Professor of Psychialry

rr-awurmwyrrwvmm

”VA-cushwr

do

if,

would be pleased To hava your @iecfreencephaiographer
us and describe our sysfem in person if Thaf is useful.

-

..

we

is of ilffle True clinical value a? preseni. if your eiecfroencephaiographar has a specific inferesf in establishing a
compuier analysis sysfam, i would sugges? The? he confacf
Dr. Enoch Callaway af The Langley Porfer‘Ciinic in San Francisco.

m-va-rw

.1

applications for

Mszp

�</text>
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                    <text>,.-

y-.;

n,

«an»;

'ww"

1
ﬂy!

“:a'wv'l’w

.u-mw

‘1'

-.:

wacn

2.

-wv-..—y

r

«u—rwwnmr

rev

April

2|,

I970

Dr. Sidney Merlis
CenTral lslip SfaTe Hosplfal
Cenfral lsllp, New York
Dear Sid,
The
me In

enclosed recommendaflon of J. P. Green

error.

The

I

presume

draf+ of

in lO—l4 days.

my

fhls

was lnfended

presenfafton at fhe

was

ACNP

Fink,

M.D.

Professor of Psychlafry
Mszp

cc: Dr.

Samuel Gershon

To

wil! be ready

Sincerely yours,
Max

senf

for your commlffee.

�</text>
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                    <text>~~u-. “7.5.”:

;-

mm

~

.77;

v:

.0

., .,

.1.

--.-

.p

--

-~.r.-

April

“7‘

--v—

2|,

,

r-iwvywv.

v:

,

w.

-.v

1',

i... .mm

.w

—

w-N

1970

Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Wilma,
Our cﬂnlcal GP sludy is prOQrosslng well buf we are in
need of additional placebo supplies. May we ask for l0 x 50

placebo?

affached.

A-label for idenfificafion of our present supply is

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

MF:kp

\

�</text>
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                  <elementText elementTextId="103277">
                    <text>“i
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-07.”.

r—r~.~7

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-vw—w~

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vamu

April
Wv-v'v'rr-m—ru

Hud—rm'an‘

2i,

i970

Dr. Loonfi H. Thompson
Program Chief, Menfai Heaifh Services
Confra Cosfa Counfy Medical Services
2500 Alhambra Avenue
Marfinez, California 94553

warm-‘1'.“

Dear Dr. Thompson:
w-ry

‘

applicafions for EEG analysis, as we do,if,
is of iiffle frue clinical value af presenf. if your elecfro—
encephalographer has a specific inferesf in esfabiishing a
compufer analysis cysfem, i would suggesf fhaf he confacf
Dr. Enoch Callaway af The Langley Porfer Clinic in San Francisco.
The computer

vlslf

i

would be pleased #0 have your eiecfroencephaiographer
us and describe our sysfem in.person if fhaf is useful.

Sincerely yours,
Fink, M.D.
,
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>-._

.
M,

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Aprll 23, l97Q
Mr.

Charles

B. McCoy,

Presldenf

E. l. DuPont de Hemours, lnc.
DuPonf Bulldlng
Wilmlngfon, Dalaware l9898
Dear Mr. McCoy:

For more fhan lhree years, fha sfaff of fhls Department
of Psychlafry has collaborafed wlfh Endo Laboraforles ln fhe
cllnlcal fesflng of naloxone ln fhe freafmenf of oplale
dependence. Our flrsf cllnlcal frlals were reporfed In l968,
and slnce +hen we have encouraged Endo +0 make available
sufflclenf cllnlcal materlal +0 extend These frlals.

oral naloxane ls rapldly desfreyed, and fhaf
parenferal naloxone ls hlghly effecflva, we have repeatedly
recommended The davelopmen? of a longvacflng naloxona for fha
frealmenf of oplafa dependance.
Aware The?

Early In l969 we proposed such a development To varlous
agencles, lncludlng fhe Na+l0nal lnsfllufe of ManTal Health
and to The New York Slafe Narco+lc Addlcflon Cmnfrol Commlsslon.
We have recenfly been assurad a? flnanclal supper? from one of
fhase agencles, and may achlava addlflonal supporf from anofher.

for

Meanwhlle, we have requasfad Endo make supplles avallable
conllnued cllnlcal Trials, and once again, as ln l967-68,

hava recalved verbal assurances That fhe supplles will bﬁ
forfhcomlng, bu? fhey fall #0 malerlallze. A copy of our
communlcaflon ls enclosed.

lafasl

wlfh control assumed by DuPonf, and anflclpaflng The posslblllfy
of some changes in Endo's prlorlfles in fhe healfh care fleld,
l dlscussad our problems wlfh Dr.
Jurg Schnelder of your company
In February, and receivad a sympafheflc hearing.

"v“

'

�I

am

wrlflng

Today +0

brlng naloxone

To your

alfenflon.

Naloxone has some speclal publlc healfb posslbllllles. If
warrants a more rasponslva managerlal leadershlp ln maklng
oral supplles avallable for'audy, and ln exploring all feaslble
approaches To a long acllng parenferal form. May I ask your
alfenflon To fhls lmporfanf chemlcal and your encouragement ln
maklng fhe suppllas needed for conflnued cllnlcal sfudles?

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MP

:

kp

cc: Dr.

A. M. Freedman

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                    <text>April 23, 1970
Dr. w. Clarke Wescoe

President

Winthrop Laborarorids
90 Park Avenue

up

—

.gmq.&lt;—,,.p.~,y.‘

New

York,

New

York 10016

Dear Dr. ﬁancee:

.
.7,

WW“

We have read of your appoinfmonf as President of winfhrop
Laboraforids wifh inleresl, and 3rd wrifing To express our
congrafulaflons, and To bring To your offdnilon, cyclnzoclne ~
a valuable producf devoiopod by Sioriing~Win+hroo and now in

clinical trial.

Since 1965, cyclazocine has been under sfudy in The iron?menf of Opioid dependence. ﬁuch of ind dafa of clinical pharmacology,

parflcularly efficacy, seldcfed populafions, dosage, side effecfs
and Their managemenf, have been collecfod in our lahorafories and
have documonidd Those obsorvafions in numerous reporfs (see
aTTached 115+).

we

The clinical applicability of cycldzocino has boon impressive,
have been encouraged f0 underfakd more exronsive clinical
Trials « a siudy in opioid depdndenf subjecTs-is in progross.

and

wo

A principal
problem in fhls froafmonl is The daily administraflon
of dosage, for The oplafe dopendanl subJocf is noforiousiy unreliable.
We have urged The developmdn? of a long-acfing, injecfable (or oral)
form of cyclazocina. We are awaro of rho offorfs of Dr. Seymour
Yolles of lhe Unlversify of Delawaro, under an NlMd granf. Such an
effort alone seems inadequale lo The need, and we have suggesfed fhaf
ofhdr roufos also be fried.
w"

~

magnum

Our suggeslions have boon made lo various local and halional
health research funding sources and we have reconfiy been assured
of financial supper? for such a study.

weeks ago,
called Dr. Joseph Bird of STeriing-Winfhrop,
f0 sugges? a review of The clinical and technical sfudy programs
Some

'4‘«w"-mspnrvvrm-anwawmv

«lav-1:1"

'r
-

WWW-V”

awn-v»

,-

eraRvL'H-‘uu

we

_&lt;.

my

1

of cyclazocine, requesfing fhe opporfunliy To presenf our recenf
(unpublished) experiences, wilh The inienflon of sfimulafing renewed
inferesf in This compound, and a more acfive coilaborafion in developing
a long~acfing form of cyclazocine.

�I

am

*0 your

April 23, [970

~2-

Dr. Wescoe

wrtflng

affenflon,

This program.

To

bring +he programs daveioped

and

To

In your company
of
fhe presenf sfafus of
urge your review

Again, our congrafulaflons on your appolnfmenf, and our
bes+ wishes for your conflnued success.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

enc.
A. M. Freedman
Dr. Joseph 31rd

cc: Dr.

�April

2:,

i970

PUBLICATION LIST

Deparlmenf of Psychlafry
York Medical College

New

Freedman, A. M., Fink, M., Sharoff, R. and Zaks, A. Cyclazocine
and Mefhadone in Narcofic Addicfion. JAMA, 202: i9l—l94, I967.
Freedman, A. M., Fink, M., Sharoff, R. and Zaks, A. Clinical Sfudies
of Cyciazocine in NarcoTic Addicfion. Amer. J. Psychia+.,

I24: l499-l504, I968.

Freedman, A.

M.

and Fink,

In The Treatmenf of

63:
Fink,

M.

59—69,

and

i968.

iiil,

T.

M.

Basic Conceprs and Use of Cyclazocine

Narcofic Addicfion. Bril. J. Addlcf.,

EEG

and Human Psychopharmacology iv: Clinical
— A Review of
Progress

Anfidepressanfs.
I957—i967, Efren, 0., Cole, J., Levine, J. and Wiffenborh, J. R.
(E35.), U. S. Gov'? Prinfing Office, Washingion, D.C., pp. 497—
In Psychopharmacoiogy

507, I969.

Fink,

and Human Psychopharmacoiogy. Ann. Rev. Pharmacoi.,
9: 24i—258, I969.
M.

EEG

Zaks, A., Bruner, A., Fink, M. and Freedman, A. infravenous
Diaceryimorphine (Heroin) in Studies of Opiafe Dependence.
Dis. Nerv. Sysf. Suppl., 30: 89-92, i969.
Fink,

Narcofic Anfagonis+s and Subsfilufes In Opiale Dependence.
In The Presenf Sfafus of Psychofropic Druge, Cerlerfi, A. and
Bove, F. J. (Eds.), Excerpfa Med. Fdn., Amsferdam, pp. 428-43l,
M.

I969.

While, R.

P.,

Drew,

W.

G. and Fink, M.

of Agonisfic Actions of Cyclazocine
I: 3l7-330, l969.

Fink,

Neuropharmacoiogicai Analysis
In

Rabbifs. Biol. Psychia+.,

and Freedman, A. M. Anfagonisfs in The Treafmenf of
Oplafe Dependence. in Modern Trends in Drug Dependence and
Alcoholism, Phillipson, R. V. (Ed.), Bufferworlh, London,
M.

pp. 49-59,-l969.

Fink, M., Simeon, J., ilii, T. and Freedman, A. M. Clinical Anfidepressanf
Acfivlfy of Cyclazocine - A Narcofic Anfagonisf. Clin. Pharmacol.
Therap., ii: 4I-48, I970.
Resnick, R., Fink, M. and Freedman, A. M. Cyclazocine Typology in
Oplafe Dependence. Amer. J. Psychia+., I25: l256-2260, I970.

�PUBLICATIONS

(conflnued)

PRESS
0mm
IN

Fink, M., Zaks, A., Resnlck, R., and Freedman, A. M. Treatmenf
of Haroln Dependenca wlfh Opiate An*a§onlsfs. In purrenf
Psychlafrtc Theraptes, Masserman, J. (Ed.), Grune and Sfra?+on,
New York.

FjékgwM;;*Zaks, A., Resnick, R. and Fraadman, A. M. Opiafa Anfagonlsfs
In The Treafmen? of Heroin Dependence In Man. In Blochemlggi
Phannacotogy of Narcofic Analgesic qugs, Clouef, D. ZEd.5,
Plenum Publ. 00., N.Y.

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                    <text>_

:

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Aprll 23, l970
_
A

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-

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Dr. Ralph Jacobson

Endo

IQOO

Laboratorlss

Sfowarf

Garden

Clly,

New

York ll530

mﬁ‘a-n-

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Door Ralph,
Some months ago, we dlscussod the posslblllly of a broad
cllnlcal lrlal of oral naloxono ln slnqle large dally doses
(2.4 lo 3.0 Gms) ln oplafs dependenf subjects. You wlll recall
That no roporfed our obsorvallon lhal dolly doses of l.2 and 2.0

falled To profecl our subjects beyond l8 hours lo 25 mg
lnfravonous heroln, bu? the? 2.4 and 3.0 Gms wore sffscflvo for

Gms

more Than 24 hours.

Upon your reassurance Thal Mr. Bovld Kloln, your vlcs~
prosldonl, had personally rooussfsd fhs suppllos be made avollable,
we rolurnod our romslnlng naloxone, so Thaf The larger lablols
could be prepared.

Durlng The pas? 6 months us have received monfhly roassurances
That naloxono would shorfly be avallablo. ln your message lasl
week, you slated fhal prlor calls on your suppllos. plus dlfflculflos
a? Molllncrodf Chomlcsl, plus expense and olher»oommllfmsn+s a? Endo,
made if unllkoly lhaf naloxono would be avsllablo for cllnlcal lrlals
before Soplember of The oarllosl, and roallsflcally, probably no?
unlll +he end of rho yssr.
Mosnwhllo, lho publlc press lndlcalss (from your release?)
an NBA for Narcan ls lmmlnonf ”wllh cllnlcal ovaluollon
expoclod To be complsled wlfhln 6 lo 8 monfhs on Tho drug's efflcacy
ln horoln and oplofo dopondonoo.“ Tns roporf makes erroneous
references lo the work In fhls laborafory, and oven allowlng for
roporfsrlal errors, l am concerned +ha+ l may be mlsquofsd - not
only #0 The press, but To rogulafory agonclos as woll.

lhaf

Our flndlngs wlfh oral naloxono ln 7 cases have been publlshed.
flndlngs wllh dosages to 3.0 Grams/day are confldenllal
and were reported lo you To supporf our collaboraflon, and were not

Our subsoquenf

avallable for

FDA

submlsslon or publlc reporllng.

V

.

,

,

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Dr. Jacobson

-2-

April 23, l970

»

A-vr

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i hope The misquoTaTion did noT
resulT from an Endo reloasa,
buT did come from an enThusiasTic roporTer's misquoToTion of
our
preliminary reporTs To The STaTo NarcoTlc AddlcTion ConTroi Commission.

‘i am wrlTing Today

for

The following

reasons:

i. To record my undorsTandlng of your Telephone call
oral naloxone ls noT available for clinical Trial in opiaTe dopendonco in daily doses of 2.4 To 3.0 Grams; and ThaT The earliesT
daTo for such supplies may be SopTombor i970.
ThaT

us during

2.

To requesT ThaT The supplies of naioxono, roTurnod by
The winTor, be made available To us once again. As
you

recall, we have boon able To adminisTer cyciazocino very rapidly,
proTochnq our subjecTs againsT The agonisTic offocTs of cyclazocine
by oral nnloxono. We have found ThoT 300 mg naloxone, 3 To 4 Times
a day for 3~5 days, is useful in cyciazocine lnducTion. We wish To
TosT This observaTion in 50 consecufivo addlcTs, and
require 4.0 Gms/
subjocT or 200 Ems. our presenT supplies are almosT exhausTod.
we would like To carry ouT This sTudy as
rapidly as posslbie.
Can you reTurn 209 Gms naloxono in 303 mg (or lOO mo) TablaTs To
us wlThln a monTh?

3. To suggosT ThaT we adhoro To our undersTandlng, ThaT
oTaTemenTs regarding our work, be made by prior iniTial consonT
You will recall ThaT our College has subscribed To such
an
undersTondlng. The enclosed reporT may roilecT a TransienT lapse
of ThoT undersTanding, and i TrusT does noT soT a procedonT nor docs
lT represonT a change in our undersTondlno. 0r doos lT?

public
only.

Ha.

ww-m‘rv—

layover»

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w"

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u»

man-e:

r-c

.w;7~.w-

incidonTolly, Tho reporT of progress in a long acTing naloxone
prooaraTlon was encouraging. You will recall, however, ThaT The
figures you ouoTed, regarding The amounTs of naloxone
To onTagonlzo heroin in our subJeCTs, seamed ouT of Thenecessary
range of
our experience. i suggosT ThoT Those figures require revlow,
parTlcularly if The pharmacouTlcai chemisTs oro using Them as
bonchmarks in Their work.

will call your office in lo days, if i have noT heard sooner,
regarding your release of 200 Grams naloxono for a cyclazoclne-naloxone
i

sTudy.

Sincerely yours,

yruvap',"-‘WL

Max

Fink,

M.D.

Professor of PsychlaTry
MF:kp
GUC.

�</text>
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                    <text>&lt;.'v;.rt-v—

April 24,
ﬁr. Turan M. 1:11
Missouri Institute of Psychiatry
5400 Arsanal Street
St. Louis, Missouri 63139
Dear Turan,
I have been checking my

v—qu

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v-

viva“

.mwu-

5-

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1970

data
for your files.

sheets from your study.

data books, and found the enclosed
Don suggested I sand these to you

Sincerely yours,
Fink, $.ﬂ.
Professor 0f Psychiatry

Max

MF:kp
BBC.

�</text>
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                    <text>«mm-m-mw——“ an
--

April 27,

.u'wrw.~!wﬁ‘nan—rawmm-u-vw.um ..

1970

Dr. Albert Silverman
Rutgers Hedical School
New Brunswick, New Jersey
Dear Al,

I look forward to participating in the APA Divisional
meeting in Newark in November. The program participants are all friends
and I am sure we will have an interesting experience.
the focus would be convulsive therapy.
program should focus on this, and the title
"Neurophysiological Aspects of Treatment" might be focussed in the
title, ”Neurophysiological Aspects of Convulsive Therapies”. If the
program is more general, and related to drug therapies as well, then
the title should be more descriptive, like " Neurophysiological Aspects
of Somatic Therapies".($omatic may be replaced by organic or biological).
Noch mentioned

If that is so, then the

My

best regards,

and

my

thanks for the

invitation.

Sincerely yours,
Max

Fink, ¥.D.

Professor of Psychiatry

mf/

“WV—warn.mw—v. -&lt;

�</text>
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                    <text>E

,3

g

April 28.

1970

Dr. Alejandro Zaffaroni
3401

Hillview

Avenue

Stanforﬁ Industrial Park
Palo Alto, California 94304
Dear Dr.

zaffaroni,

we are faced with a difficult drug dolivery problem, an&amp;
in reading ﬁrug Research Reports, read of the formation of A123 Corporation,
with its focus on drug delivery prohlems. I am writing to enquire whether
Alma can assist us in too following problem.

Naloxono is a spocific opiate antagonist. which we have
found useful in treating Opiate dependence (01in. Fﬁarmaool. Therap., 9:

563,577, 1%58). Go oral administration. naloxone is either rapidly
destroyed or poorly absorbed, for large cases (3.0 Cms/day) are required
to achieve antagonism to heroin for 24 hours. a minimum for therapeutic
usefulness. 0n parenteral administration, 0.6 to 1.2 mg/B hours are
needed to maintain effective antagonism.
ﬁalexone is produced from tocbcinc, a prosctibed drug,
and producing supplies for oral use is impossible. In our discussions,
we have focussed on parenteral administration. and considered the
development of a long acting parenteral form, possibly in a silostic
type vehicle. We proposed such a development to the usual research
funding agencies and have received sufficient initial support to under?

takc feasibility

trials.

If A123 is intorostcd, I would appreciate the opportunity
with
meet
to
you. I plan to be in San Francisco for National meetings
May 9w13 and can be reached at the Hilton Hotel or in ﬂew York (212~369 7900).
I look forward to hearing from you.
Sincerely yours,

mf/

cc: Prof. A.

Max Fink, 14.9.
Professor of Psychiatry
Director, Division of Biological
Psychiatry
vi.

Freedman

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April 30, I970
Dr. Sidney Merlls
Confral Islip State Hospital

Central

lsilp,

New

York

Dear Sld,

Enclosed is a rewrite of my prosenfaflon before fhe ACNP
In February. I Trust If us usefut and look forward fo,fhe

publlcaflon.

Sincerety yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp

enc.

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                    <text>March 1, 1970
Dear Professor Hippius,

for

I am writing on behalf of Dr. Milton Kletzkin,
membership in the CINP.

I have known Dr. Kletzkin for more than 10 years,
and followed his work with interest. He is an experimental
neurophysiologiet and neuropharmaoologist with special interests
in the the effects of muscle relaxants and sedative anxiolytice.
He is a fine speaker and has contributed intelligently to the
symposia in which he participated.
At the recent meeting of the program committee, I
put forward a suggestion that a symposium be organized to
relate the CNS effects of drugs in various animal species,
and I had his cooperation in mind for that program.

It gives

me

pleasure to

recommend

his

membership.

Sincerely yours,

Max

Fink, M.D.

New

York Medical College

Professor of Psychiatry

Prof. H. Hippius
Nervenklinik der Freien Universitﬂt

Berlin,

Germany

�</text>
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                    <text>March 1, 1970

Dr. Charlas Shagass

secretary, 83?
Philadelphia, Pa.

Re; Leo

Hollistar

.
-»

-—«“ml-‘

Dear Charles,

”at

V'

rat-r"

‘Wmtu-“ar'w'lﬂrﬁﬂllmn

Leo

It gives

Bollister for

Psychiatry.

me a great plaasure to rccommcnd Dr.
membership in the Society of Biological

I have known Leo since 1960. when we both served
in the Clinical Committce of the NIMR. l have found him to be
a sincere. industrious, creative researcher, with a flnc grasp
cf the physiology of psychoactive drugs and an extraordinary
interest in the biological effects of chess compounds. Ha has
written extensively in paychepharmacolegy, clinical toxicology
and has contributed extenaivcly to the VA collaborative study
programs.

He is among the fcw clinicians who have mace use of
the EEG in his evaluations, ané while I tcnd to disagree with his
conclusions, his data is wall collected and tell prascnted.
He

will make a fine
heartily.

recommend him

member

of the Society and I
Sincerely yours,
Fink, H.B.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="105851">
                    <text>Fr

,

m...

,

,

w

W -. -

.7“... .,.-_

..

.

.v.

n,

.-

“WW...

.7... ”V

_

m...

.. .._,.V _. ,

.1” .

.,..

,.

“‘

“1"

“PL

"urn-mtg“

March 1. 1970

(«II-um:

r
an:

Professor Alan Kraft

Department of Psychiatry
Albany Medical Collega of Quiet University
Albany, New York
ﬁaar Professor Kraft,

I have knawn of Dr. Keelar*a work for many years.
and nine; July, 1969, I have had more direct contact with
him in this Department of ?sychiatry. His record in North
Carolina is well known and his work there was of the calibar
tn receiva recognitian both by HIKE in its Carter Development
Program and by the University where he was promotad to full
Prefessor. Kin reasons for leaving ﬂorth Carolina seem to have

bten parsonalvv a desire of a New Yorker ta raise his family in
ﬂaw Yark-~ and not professional.

Since coming to New Ycrk Medical Collage, he has been
unable to make use of his abilitics~~ in part, because of the
liwited clinical facilities at his diagonal, and in part because
of the expcctntionu that funds ware already available, which were
indeed not yet awarded. ﬁe has carriaé out a teaching yragram
with psychiatric residenta and this has been done wall, for both he
and the students have been enthusiastic and they have raqucsted an
increase in their exposure to his teaching.

I believe him ta be a good researcher, capnble of undertaking prograns in aubutance abuse and schizophreniaww two subjects
of mutual interest. ﬁe writes well and his concaptualizatian of
a study program in cannabis was wall ptesanted. We understand that
tha project was racammended for support by the study atetian at
MIME but remains unfunéed because of the continuad lack of
a budget
for REV, rather than any inharent problem with the prtaentntion.
His persunality can best be described an raserved,
unassuming and mmdarately insensitive. He is forthright and cooperative
with his junior: and has exhibited the ability to relata to other
staff membara, particularly those in tha training divisions.

�Prof. Alan Kraft
We

.

.

.

.

.

.

.

.

.

.

.

. Page 2.

have not had an opportunity to evaluate his role as

administrator.

likeablo and cooperative in personal
matters, but uncooperative in his professional relationship with
a
I have

.
r

found him

part, this rooultad from the unfortunate assignment as
of this Division without an independent clinical base,
staff, most
requiring him to relate for patient mottoro with myRoaaaignmont
to
of whom are loyal to my ptinciplos and interosts.
him was difficult, and it soon become obvious that such a
partition of the limited clinical material woo not acceptable to
ma ; and a collaborative rolationabip with another Protease: was
him for
not acceptable to Martin. In largo port, I cannot bloom
have
not
his diaoppointmont, and I believe that his abilities
bad thn opportunity in this Department to oXprose themselves.

mo. In
member

«r.

W'fv”sz-m‘mwmuxw’mym-rsmuv.

'7‘“.

319.4,“.-

»«

v.
w

H'me

V731“

Ham

.»

'
.

l boliovo that he would do very well as a clinician
and a rosoarchot in a oooarate and well defined clinical facility.
Hie projoota will to wall prosentod and ovon in this competitive
climate» ohoold achieve rocognitoon and suyport. Ho relatos well
It
to students and bio toacniug will he acceptod with onthoaiaam.
him
this
$xooﬁmon
to
agpoﬁwtod
recommendation
that
3:.
was on my
Collage, and { bolﬁevo that if tho ?aoilitiao were aﬁoquato for
two oatallol programs, he would have been happy and have carried
out his work with distinction.
he should be given aoothor opportunity, and I am confident
he will be able
that if he to givan the facility and the authority,ﬁoxth
ﬁarnlina.
to achieve the potential doocriboﬁ in hio oath in

”M‘W‘V

.rw

v

I trust theoo

comments have

for tho succeoo of your program.

utility.

my

host wishes

Sincerely yours,

Pink, v.9.
Professor of Psychiatry

Max

of]

�</text>
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                    <text>ﬂnrch 1, 1970
Br.

A1

Bantam

ﬂinascia
Scat: Kaspital

Boston, Manaaahuuetts

meat A1,

I:

so thank you

with you at tbs Agar, 3nd I want
far participating in th: panel on training. Tau:

wan fun marking

noumanta war.

:90: haipful, Iné I

axculleuce of your programs.

must coagratultco yen an uh:

I in writing to c$k your approval for Dr. Javan Simeon
and his naaiataut, Dt. Jgnn Robson, to attend your farthcening
nympasiun on yoychaphnruncalogy 1a childrnu on unreh 11 3nd 18.
I undarltand the aynpotium will be bald A: the Cashing ﬂosyital
in Yruuinghan.

many

thanks,

an&amp; my

baa: regards.
Sinccruly yours.
Max

Fink,

M.D.

frofeauor of Psychiatry

mf/

‘

�</text>
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                    <text>March

3,

1970

Mary J. Kauffman
Manager. Direct Mail
Advertising and Promotion

Book Medical Publishers
East Wacker Drive

Year

p414;

fr.

35

Chicago,

Illinois

60601

vary-smug,»

I)

.‘a't

""vawlmm-

Dear Miss Kauffman:

It has not been the policy of this Association to date to
use its mailing list fer non~scientific purposes. The next
meeting of Council is in October, 1970 and I will be glad to
present your request to the officers at this time.
Sincerely yours.

7w

Fink,
Secretary

Max
alwsyar.

Mme

[rpm-7x

1w
“

”75‘?!"

W
~'

:‘Z’mﬂrif!:1¢5'.i’v'€

.‘e’r'W

waiwram

E’s'ﬂ‘ﬂw‘l'r’ﬁ.

mmzzvmv;

MF:kp

M.D.

�</text>
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                    <text>xvi"

-

'

"

‘

"N

'

“‘

"

‘

‘

'W‘VM-W‘W'W“

"'

:-

"‘V‘"NI

vwv

..‘

..

m.-u...,..,.

.-

.

..

.__....

N

,

March A, 1970

Koliday Inn

?.0. 3012317
Aspen, Colorado
Gentlemen:

_
_

w—wwmw

Vleusa cancel the reservation that I made for my
attendance at the Western EEG ski tastings. I regrnt the

inconvenience,; please assign my
as I will not be «bl: to attend.

room

:0 another atcandea,

V.“

,
‘
w

9
-

w‘nv-‘w-w

Thank you.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>March

4.

1970

Dr. Lewis L. Levy
290 Meeting House Lane

Orange. Connecticut
Dear Lew,

After many years, the report on cycloserine has finally
appeared in press. I am pleased to enclose a copy. We found
this application in exacerbating schizoohrenic behavior very

useful.

Since leaving Missouri, I no longer have chronic
schizophrenic pat ents and have no longer continued this
line of work.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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4,

1970

Dr. N. Keop
681 Ciarkson Avenue
Brooklyn, New York 11203
Dear Dr. Keup:

Enciosed is an abstract for your consideration for the
first Muitistate Interhospitai Conference of EPRA. Dr. Abrams

will present this report. If it is at ali possible. he would
appreciate a presentation on Friday since he has a prior
commitment on Saturday.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

enc.

�</text>
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                    <text>‘

March 4, 1970
Mr. Herb

Sturz

Institute

Vera

30 East 39th

New

York,

New

Street
York

Dear Mr. Sturz:

Enclosed is a draft proposal dated November 27, 1969, which
describes our suggestion to the National Institutes of Mental Health
and to the New York State Narcotic Addiction Control Commission for
the development of a long acting narcotic antagonist.
Since formulating the proposal we have had additional experience
with cyclazocine which makes us believe that the same principles and
techniques should be applied to the development of a long acting
form for cyclazocine as well.
For either naloxone or cyclazocine, the first step is the
development of a slow release form and a determination of a maximum
amount

that

can be concentrated in a

silastic vehicle.

The

initial

animal trials must be undertaken to determine the release rate.
These pharmacological aSSays can be done by a number of American
consulting firms. If this formulation is successful, then concurrent
animal and human trials must be undertaken in the animals for toxicity
purposes and in humans fer toxicity and the determination of the
duration of antagonism.

requested are for the pharmacological feasibility
such actions appear logical to you and your committee,
associates and I would be pleased to cooperate in any way possible.

only.
my

The fUnds

If

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
enc.

�</text>
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                    <text>March

4,

1970

Dr. M. Keup
581 Ciarkson Avenue
Brooklyn, New York 11203
Dear

8r.

Keup:

Enclosed is an abstract for your consideration for the
first Muitistato Interhospitai Conforonce of EPRA. Dr. Abrams

wiii present this report. If it is at all possible, he would
appreciate a presentation on Friday since he has a prior
commitment on Saturday.
My

best regards.
Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬁszp
ehc.

�</text>
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                    <text>harch 4, 1970
Mr. Edward Aifeno

*

Import Spocieiist

Custom House
Bowiing Green,
’

New

York 10014

Dear Mr. Aifano:

Foilowing our discussions I am enciosing the ye110w copy
of permit #2429, dated May 5, 1969. ﬁn May 16, 1969, I returned
to the United States from Athens, Greece. I brought with me

heshish, which I obtained from Professor
was inspected
J. iiiras, University of Athens. The materiai made
on the back
and
notation
a
Internatione1
Airport
at Kennedy
1
additiona1
an
had
receiving
anticipated
of the green copy.
supp1y of THC-A-9 and kept the permit in my possession. This
supp1y was not sent nor have I received it. Unfortunateiy,
neither my secretary nor I can recoii the fate of the green
copy. we do not anticipate importing under this certificate
any additiona] suppiies.

250 Grams powdered
{3.

The materie1 brought in 1est Hey, 1ess some

a1ready used in our

et

5

that

East 102nd Street.

Thank you

for your cooperation.
Sincere1y yours.

Fink. M.D.
Professor of Psychiatry

Mex

Hszp
811C 0

we have

studies, is in our controi in the 1aboratory

�</text>
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              <elementText elementTextId="42943">
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                  <elementText elementTextId="105844">
                    <text>rum—~—

r

w“,-

..;,

.-

-aw.—¢_-m-v.v-..

..—,

“new.”

..u ..

.

\

.

,.

.

r.

Y

a

1

A“.

«a; ”we‘d";

e

. m «WW7 -~ 7“.“ Twp“ rr‘ .

March

vim-“w.“ ".~_,-

m.

"w “WW..-

7,

v.

m u—w-n w “WWW—var... “We...

4, l970

Dr. Charles Shagass

Eastern Pennsylvania Psychiatric Institute
Henry Ave. s Abbottsford Road

Philadelphia, Pennsylvania l9129
Dear

Charlie.
A

copy of the

distributed at the

list

members nominated for the APPA as
meeting is attached. To the extent possible.

of

would you please have your secretary give us the addresses of
these candidates? Hould you formulate an appropriate letter or
would you trust us to do so?

If

we

My

best regards.

be glad

have the addresses and the proposed

to send out the invitations.

Sincerely yours,

‘

Fink,
Secretary

Max

;

MF:kp

enc.

M.D.

letter,

we

will

. on

in...

«"mu".

�</text>
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            <elementTextContainer>
              <elementText elementTextId="42932">
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          <element elementId="48">
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              <elementText elementTextId="42933">
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                  <elementText elementTextId="103272">
                    <text>”mu—Vw...”

March

4.

7 7,.

n

1970

Dr. Joseph C. Bird

Director of Expnrimenta1 Medicino
Ster1ing~winthrop Research Institute
90 Park Avnnue
new York, new York 10016

Dear

Joe,

to enciose two reprints of our paper “Ciinical
Antidepressant Activity of Cyciazocine - A Narcotic Antagonist“.
I am p1ensed

We

Stu dy.
Has

are gratefu1 for your support and encouragement in this
there been any progress

on a 1ong

cyc1azocine?
My

acting formu1ation for

best regards.

Sincere” yours ,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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                    <text>March

4, 1970

Dr. Lewis L. Levy
290 Meeting House Lane

Orange. Connecticut
Bear Lew,

After many years. the report on cycloserine has finally
appeared in press. I am pleased to enclose a copy. We found
this application in exacerbating schizophrenic behavior very

useful.

Since leaving Missouri, I no longer have chronic
schizophrenic pat ants and have no longer continued this
line of work.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

enc.

�</text>
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                    <text>March

Dr. Ivan Bennett
Ely Lilly Company

Indianapolis, Indiana

4,

1970

46206

Dear Ivan,
I am pleased to enclose a copy of the report ”d~Cycloserine
Therapy of Psychosis by Symptom Provocation", which resultad

studies in Missouri.
application has merit.

from the
ﬂy

As

you can

tell,

we

think that this

best regards.
Sincerely yours,
Fink, .M.D.
Professor of Psychiatry

Max

Mszp
ENC .

�</text>
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                    <text>March

4.

1970

Br. Turan M. Itii
Missouri Institute of Psychiatry
5400 Arsenal Street

St. Louis, ﬁissouri

63139

Dear Turan,

Separately I am tending you fifty reprints each of the
cycioserine and oyciazocine papers - just to prove that I
am

still

working for you.

There are an additional

whose address I do not have.
My

set of reprints for

Dr. Ponce.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 4, 1970

Dr. Alexander 6. Karczmar
Professor and Chairman
Department of Pharmacology and Therapeutics
Loyola University, Stritch School of %odicine

Chicago,

Illinois

Dear Alex,

to

Enclosed

NIMH.

is

a capy

of the supplement application

Dr. Abrams is looktig for a suitable
touch with you as soon as he finds one.

subject

and he

Sincerely yours,
Max

Pink, M.E.

Frofessor of Psychiatry

MF:kp
BBC .

as we submitted

will

be

in

�</text>
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              <elementText elementTextId="42877">
                <text>1970 </text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="42878">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="42879">
                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="42880">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="42881">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="42882">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="42883">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="78490">
                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="85051">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="91612">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="98173">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
